RPL7AP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1somatic diversification of immune receptors via somatic mutation (GO:0002566)7.46797676
2somatic hypermutation of immunoglobulin genes (GO:0016446)7.46797676
3somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)7.14909295
4somatic diversification of immunoglobulins involved in immune response (GO:0002208)7.14909295
5isotype switching (GO:0045190)7.14909295
6ribosomal small subunit biogenesis (GO:0042274)7.14292134
7ribosomal small subunit assembly (GO:0000028)6.84886874
8regulation of helicase activity (GO:0051095)6.80922269
9maturation of SSU-rRNA (GO:0030490)6.35468271
10viral transcription (GO:0019083)6.26228035
11translational termination (GO:0006415)5.97562402
12determination of adult lifespan (GO:0008340)5.75061681
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.41615693
14cotranslational protein targeting to membrane (GO:0006613)5.36676556
15ribosomal large subunit biogenesis (GO:0042273)5.33825331
16protein targeting to ER (GO:0045047)5.29485967
17somatic recombination of immunoglobulin gene segments (GO:0016447)5.20511428
18translational elongation (GO:0006414)5.16833151
19establishment of protein localization to endoplasmic reticulum (GO:0072599)5.08061526
20protein localization to endoplasmic reticulum (GO:0070972)4.88994158
21somatic diversification of immunoglobulins (GO:0016445)4.86863024
22cellular protein complex disassembly (GO:0043624)4.75626577
23ATP synthesis coupled proton transport (GO:0015986)4.68158472
24energy coupled proton transport, down electrochemical gradient (GO:0015985)4.68158472
25GTP biosynthetic process (GO:0006183)4.67169645
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.64701869
27nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.60902760
28negative regulation of DNA recombination (GO:0045910)4.53429734
29ribonucleoprotein complex biogenesis (GO:0022613)4.50388059
30axonemal dynein complex assembly (GO:0070286)4.45842868
31translational initiation (GO:0006413)4.43941191
32epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.42985138
33mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.32334632
34viral life cycle (GO:0019058)4.31775802
35sequestering of actin monomers (GO:0042989)4.28204886
36translation (GO:0006412)4.21666544
37DNA damage response, detection of DNA damage (GO:0042769)4.17817349
38protein neddylation (GO:0045116)4.12085478
39UTP biosynthetic process (GO:0006228)4.04736271
40sulfur amino acid catabolic process (GO:0000098)4.03754983
41chaperone-mediated protein transport (GO:0072321)4.03356389
42proteasome assembly (GO:0043248)4.03048742
43protein complex disassembly (GO:0043241)4.00022383
44B cell activation involved in immune response (GO:0002312)3.99238181
45positive regulation of megakaryocyte differentiation (GO:0045654)3.89960393
46cellular component biogenesis (GO:0044085)3.89850737
47macromolecular complex disassembly (GO:0032984)3.85914307
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.78922917
49behavioral response to nicotine (GO:0035095)3.72216818
50somatic cell DNA recombination (GO:0016444)3.66659978
51somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.66659978
52epithelial cilium movement (GO:0003351)3.63575812
53cilium movement (GO:0003341)3.58117369
54respiratory electron transport chain (GO:0022904)3.56969631
55somatic diversification of immune receptors (GO:0002200)3.55179307
56protein targeting to membrane (GO:0006612)3.52280271
57UTP metabolic process (GO:0046051)3.49973731
58respiratory chain complex IV assembly (GO:0008535)3.49652013
59electron transport chain (GO:0022900)3.47662427
60guanosine-containing compound biosynthetic process (GO:1901070)3.46758626
61pyrimidine nucleobase catabolic process (GO:0006208)3.41668195
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41268915
63regulation of mitotic spindle checkpoint (GO:1903504)3.41268915
64nuclear-transcribed mRNA catabolic process (GO:0000956)3.40981390
65regulation of microtubule-based movement (GO:0060632)3.38445904
66ribosome biogenesis (GO:0042254)3.32691396
67head development (GO:0060322)3.28952972
68reciprocal DNA recombination (GO:0035825)3.27111143
69reciprocal meiotic recombination (GO:0007131)3.27111143
70mRNA catabolic process (GO:0006402)3.24782340
71positive regulation of respiratory burst (GO:0060267)3.23040066
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.18159130
73short-term memory (GO:0007614)3.16165851
74cytochrome complex assembly (GO:0017004)3.13388381
75negative regulation of mast cell activation (GO:0033004)3.05295905
76purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.04871016
77rRNA modification (GO:0000154)3.00757898
78rRNA methylation (GO:0031167)3.00060499
79CTP metabolic process (GO:0046036)2.99587282
80CTP biosynthetic process (GO:0006241)2.99587282
81response to histamine (GO:0034776)2.99111892
82purine nucleoside triphosphate biosynthetic process (GO:0009145)2.98129836
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93020759
84RNA catabolic process (GO:0006401)2.92866281
85retinal rod cell development (GO:0046548)2.92475955
86transcription elongation from RNA polymerase I promoter (GO:0006362)2.92401202
87regulation of cilium movement (GO:0003352)2.92307084
88nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.92189517
89DNA deamination (GO:0045006)2.91215260
90positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.87773081
91base-excision repair, AP site formation (GO:0006285)2.86947674
92organelle disassembly (GO:1903008)2.85841658
93pyrimidine nucleotide catabolic process (GO:0006244)2.85466384
94protein complex biogenesis (GO:0070271)2.81407401
95termination of RNA polymerase III transcription (GO:0006386)2.81377585
96transcription elongation from RNA polymerase III promoter (GO:0006385)2.81377585
97hypothalamus development (GO:0021854)2.76482813
98nephron tubule morphogenesis (GO:0072078)2.75747108
99nephron epithelium morphogenesis (GO:0072088)2.75747108
100nucleotide-excision repair, DNA damage removal (GO:0000718)2.75289502

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human5.30621023
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.75282273
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61224547
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.41175739
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.21383974
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11091530
7RBPJ_22232070_ChIP-Seq_NCS_Mouse3.09760278
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.89689115
9E2F7_22180533_ChIP-Seq_HELA_Human2.83809464
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.61491567
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54462690
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.48942166
13VDR_23849224_ChIP-Seq_CD4+_Human2.25356789
14ZNF274_21170338_ChIP-Seq_K562_Hela2.21588077
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14358177
16XRN2_22483619_ChIP-Seq_HELA_Human2.12945804
17TTF2_22483619_ChIP-Seq_HELA_Human2.07364119
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06319271
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.01351632
20IGF1R_20145208_ChIP-Seq_DFB_Human2.00291050
21YY1_21170310_ChIP-Seq_MESCs_Mouse1.91141967
22IRF1_19129219_ChIP-ChIP_H3396_Human1.90460453
23ELK1_19687146_ChIP-ChIP_HELA_Human1.88278958
24ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.84186356
25EWS_26573619_Chip-Seq_HEK293_Human1.83126068
26GABP_19822575_ChIP-Seq_HepG2_Human1.81595550
27GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.76332759
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.75382205
29DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.74714270
30VDR_22108803_ChIP-Seq_LS180_Human1.72127639
31FOXP3_21729870_ChIP-Seq_TREG_Human1.69478178
32POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60913540
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.60435241
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.57090690
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53842343
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51497881
37MYC_18940864_ChIP-ChIP_HL60_Human1.51305400
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.51077784
39ELK1_22589737_ChIP-Seq_MCF10A_Human1.48972303
40MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48458725
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45570829
42ETV2_25802403_ChIP-Seq_MESCs_Mouse1.45364901
43TP53_22573176_ChIP-Seq_HFKS_Human1.44895569
44RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.44198209
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.39277892
46SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.37396925
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36251762
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35088442
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34827830
50RNF2_27304074_Chip-Seq_NSC_Mouse1.29108978
51RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28707949
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27753885
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27423648
54ER_23166858_ChIP-Seq_MCF-7_Human1.27405831
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24847473
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22621427
57SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19952977
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19726387
59REST_21632747_ChIP-Seq_MESCs_Mouse1.17680009
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.14906302
61MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12652926
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.10366818
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.10210072
64DCP1A_22483619_ChIP-Seq_HELA_Human1.09468506
65KDM5A_27292631_Chip-Seq_BREAST_Human1.08611490
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08430897
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.07396476
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04612316
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04514327
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.03315749
71SOX2_18555785_ChIP-Seq_MESCs_Mouse1.03255565
72NCOR_22424771_ChIP-Seq_293T_Human1.03095048
73P300_19829295_ChIP-Seq_ESCs_Human1.03022702
74ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02992573
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.01260005
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01260005
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.00540539
78TAF2_19829295_ChIP-Seq_ESCs_Human1.00265226
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99924853
80REST_18959480_ChIP-ChIP_MESCs_Mouse0.99175484
81YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98986995
82SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96648224
83KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.95986358
84TAL1_26923725_Chip-Seq_HPCs_Mouse0.95392179
85JARID2_20064375_ChIP-Seq_MESCs_Mouse0.94582647
86FUS_26573619_Chip-Seq_HEK293_Human0.93040931
87CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92169371
88EZH2_27304074_Chip-Seq_ESCs_Mouse0.91118197
89TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88106114
90EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87814165
91FLI1_27457419_Chip-Seq_LIVER_Mouse0.86881578
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.85396593
93POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84291160
94TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83387735
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83387735
96CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82905453
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.82229048
98GATA3_21867929_ChIP-Seq_TH1_Mouse0.81026070
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80943620
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77836506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.74069444
2MP0008877_abnormal_DNA_methylation3.87817690
3MP0006292_abnormal_olfactory_placode3.30243027
4MP0000569_abnormal_digit_pigmentation3.18070305
5MP0001348_abnormal_lacrimal_gland3.15084125
6MP0003136_yellow_coat_color2.94983809
7MP0010030_abnormal_orbit_morphology2.89623428
8MP0001529_abnormal_vocalization2.70895848
9MP0003787_abnormal_imprinting2.69762492
10MP0003122_maternal_imprinting2.67911150
11MP0005379_endocrine/exocrine_gland_phen2.31372891
12MP0002163_abnormal_gland_morphology2.30275463
13MP0002102_abnormal_ear_morphology2.27458747
14MP0004147_increased_porphyrin_level2.08075840
15MP0001968_abnormal_touch/_nociception2.05983711
16MP0003880_abnormal_central_pattern2.02817440
17MP0002735_abnormal_chemical_nociception1.89226736
18MP0004145_abnormal_muscle_electrophysio1.86452848
19MP0003121_genomic_imprinting1.77759232
20MP0000685_abnormal_immune_system1.75706834
21MP0002736_abnormal_nociception_after1.75040782
22MP0004142_abnormal_muscle_tone1.74790460
23MP0002822_catalepsy1.73813385
24MP0008872_abnormal_physiological_respon1.72207701
25MP0008789_abnormal_olfactory_epithelium1.70393166
26MP0001293_anophthalmia1.68384288
27MP0005394_taste/olfaction_phenotype1.66924863
28MP0005499_abnormal_olfactory_system1.66924863
29MP0008875_abnormal_xenobiotic_pharmacok1.62828304
30MP0005083_abnormal_biliary_tract1.60374886
31MP0005084_abnormal_gallbladder_morpholo1.54878754
32MP0005174_abnormal_tail_pigmentation1.48743948
33MP0001485_abnormal_pinna_reflex1.48286688
34MP0009046_muscle_twitch1.46299741
35MP0009745_abnormal_behavioral_response1.43581549
36MP0000955_abnormal_spinal_cord1.38775498
37MP0006276_abnormal_autonomic_nervous1.35988791
38MP0005551_abnormal_eye_electrophysiolog1.33581535
39MP0000778_abnormal_nervous_system1.30660297
40MP0003567_abnormal_fetal_cardiomyocyte1.28667293
41MP0002272_abnormal_nervous_system1.25220266
42MP0005360_urolithiasis1.22968451
43MP0008995_early_reproductive_senescence1.21175195
44MP0003635_abnormal_synaptic_transmissio1.20440039
45MP0004859_abnormal_synaptic_plasticity1.20102953
46MP0002067_abnormal_sensory_capabilities1.19162070
47MP0005645_abnormal_hypothalamus_physiol1.18764747
48MP0001440_abnormal_grooming_behavior1.18541240
49MP0004811_abnormal_neuron_physiology1.17248520
50MP0002095_abnormal_skin_pigmentation1.13810731
51MP0001970_abnormal_pain_threshold1.13743772
52MP0001984_abnormal_olfaction1.10374717
53MP0005671_abnormal_response_to1.08696554
54MP0002063_abnormal_learning/memory/cond1.07566423
55MP0004381_abnormal_hair_follicle1.05080973
56MP0003878_abnormal_ear_physiology1.03727593
57MP0005377_hearing/vestibular/ear_phenot1.03727593
58MP0004133_heterotaxia1.02732896
59MP0002733_abnormal_thermal_nociception1.00457035
60MP0000631_abnormal_neuroendocrine_gland0.97823166
61MP0003123_paternal_imprinting0.97390916
62MP0004742_abnormal_vestibular_system0.94501017
63MP0002064_seizures0.94404501
64MP0003329_amyloid_beta_deposits0.94048071
65MP0001905_abnormal_dopamine_level0.92939367
66MP0002229_neurodegeneration0.92438328
67MP0001324_abnormal_eye_pigmentation0.90854011
68MP0000015_abnormal_ear_pigmentation0.90443818
69MP0005253_abnormal_eye_physiology0.89833109
70MP0002277_abnormal_respiratory_mucosa0.88837727
71MP0002882_abnormal_neuron_morphology0.88646639
72MP0001286_abnormal_eye_development0.88259202
73MP0001986_abnormal_taste_sensitivity0.88193126
74MP0002557_abnormal_social/conspecific_i0.86229896
75MP0002734_abnormal_mechanical_nocicepti0.85170260
76MP0002938_white_spotting0.84142721
77MP0000639_abnormal_adrenal_gland0.83910434
78MP0002837_dystrophic_cardiac_calcinosis0.81667222
79MP0005195_abnormal_posterior_eye0.81395795
80MP0002233_abnormal_nose_morphology0.81142268
81MP0002909_abnormal_adrenal_gland0.80560374
82MP0005075_abnormal_melanosome_morpholog0.79738865
83MP0008057_abnormal_DNA_replication0.79378680
84MP0005646_abnormal_pituitary_gland0.78303959
85MP0005391_vision/eye_phenotype0.76891250
86MP0002638_abnormal_pupillary_reflex0.76771066
87MP0000049_abnormal_middle_ear0.76492407
88MP0002152_abnormal_brain_morphology0.75126430
89MP0008058_abnormal_DNA_repair0.74211978
90MP0005423_abnormal_somatic_nervous0.74203689
91MP0006072_abnormal_retinal_apoptosis0.73992264
92MP0001764_abnormal_homeostasis0.73645535
93MP0002653_abnormal_ependyma_morphology0.73341707
94MP0003937_abnormal_limbs/digits/tail_de0.71211422
95MP0002138_abnormal_hepatobiliary_system0.70005054
96MP0002572_abnormal_emotion/affect_behav0.67105874
97MP0002752_abnormal_somatic_nervous0.66238053
98MP0001502_abnormal_circadian_rhythm0.64407411
99MP0005670_abnormal_white_adipose0.64100572
100MP0003861_abnormal_nervous_system0.63659032

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)6.39415877
2Agnosia (HP:0010524)6.23707242
3Reticulocytopenia (HP:0001896)5.35931547
4Rhabdomyosarcoma (HP:0002859)4.76458843
5Astrocytoma (HP:0009592)4.39397331
6Abnormality of the astrocytes (HP:0100707)4.39397331
7Biliary tract neoplasm (HP:0100574)4.19400413
8Medulloblastoma (HP:0002885)3.76742875
9Neoplasm of the oral cavity (HP:0100649)3.56251185
10Stomatitis (HP:0010280)3.55423905
11Aplasia/Hypoplasia of the sacrum (HP:0008517)3.53997540
12Thrombocytosis (HP:0001894)3.41231766
13Glioma (HP:0009733)3.37525744
1411 pairs of ribs (HP:0000878)3.36380314
15Acute necrotizing encephalopathy (HP:0006965)3.35172175
16Neoplasm of striated muscle (HP:0009728)3.12391491
17Angiofibromas (HP:0010615)3.10559970
18Adenoma sebaceum (HP:0009720)3.10559970
19Macrocytic anemia (HP:0001972)2.96488652
20Abnormality of cells of the erythroid lineage (HP:0012130)2.95094255
21Progressive macrocephaly (HP:0004481)2.94892824
22Increased IgM level (HP:0003496)2.93157765
23Abnormal mitochondria in muscle tissue (HP:0008316)2.89233842
24Abnormal ciliary motility (HP:0012262)2.85971038
25Amaurosis fugax (HP:0100576)2.84227605
263-Methylglutaconic aciduria (HP:0003535)2.81024037
27Mitochondrial inheritance (HP:0001427)2.79831745
28Basal cell carcinoma (HP:0002671)2.73647085
29Abnormal respiratory motile cilium morphology (HP:0005938)2.72820171
30Abnormal respiratory epithelium morphology (HP:0012253)2.72820171
31Increased CSF lactate (HP:0002490)2.71417679
32Acute encephalopathy (HP:0006846)2.71177006
33Increased hepatocellular lipid droplets (HP:0006565)2.69967808
34Hepatic necrosis (HP:0002605)2.68005608
35Neoplasm of the rectum (HP:0100743)2.63490447
36Hepatocellular necrosis (HP:0001404)2.61368382
37Colon cancer (HP:0003003)2.56973783
38Spontaneous abortion (HP:0005268)2.56765943
39Missing ribs (HP:0000921)2.55466261
40Cerebral hypomyelination (HP:0006808)2.53766818
41Respiratory difficulties (HP:0002880)2.51502462
42Lipid accumulation in hepatocytes (HP:0006561)2.44769473
43Pachygyria (HP:0001302)2.40026039
44Abnormal respiratory motile cilium physiology (HP:0012261)2.39158252
45Abnormality of the salivary glands (HP:0010286)2.38990136
46Abnormal number of erythroid precursors (HP:0012131)2.36138759
47Neoplasm of the small intestine (HP:0100833)2.35627733
48Supernumerary spleens (HP:0009799)2.35277448
49Neoplasm of the liver (HP:0002896)2.27023990
50Increased intramyocellular lipid droplets (HP:0012240)2.25437081
51Abnormal biliary tract morphology (HP:0012440)2.24456864
52Renal cortical cysts (HP:0000803)2.19921279
53Short middle phalanx of the 5th finger (HP:0004220)2.19201252
54Metaphyseal dysplasia (HP:0100255)2.18937375
55Cerebral edema (HP:0002181)2.17815140
56Molar tooth sign on MRI (HP:0002419)2.15769354
57Abnormality of midbrain morphology (HP:0002418)2.15769354
58Abnormal lung lobation (HP:0002101)2.11076619
59CNS hypomyelination (HP:0003429)2.07654364
60Congenital stationary night blindness (HP:0007642)2.05882895
61Pallor (HP:0000980)2.04811203
62Myokymia (HP:0002411)2.00359164
63Birth length less than 3rd percentile (HP:0003561)2.00252042
64Optic disc pallor (HP:0000543)1.99725814
65Febrile seizures (HP:0002373)1.98386100
66Abnormality of alanine metabolism (HP:0010916)1.98219306
67Hyperalaninemia (HP:0003348)1.98219306
68Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98219306
69Neuroblastoma (HP:0003006)1.97729777
70Primitive neuroectodermal tumor (HP:0030065)1.97729777
71Neuroblastic tumors (HP:0004376)1.97729777
72Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.97729777
73Pancreatic fibrosis (HP:0100732)1.97573781
74Polyphagia (HP:0002591)1.94898181
75Bifid tongue (HP:0010297)1.94541125
76Pancreatic cysts (HP:0001737)1.93935349
77Abnormality of the septum pellucidum (HP:0007375)1.91516271
78Renal Fanconi syndrome (HP:0001994)1.90018425
79Focal seizures (HP:0007359)1.89684939
80Anophthalmia (HP:0000528)1.89311690
81Prominent metopic ridge (HP:0005487)1.88364961
82IgA deficiency (HP:0002720)1.87918035
83Focal motor seizures (HP:0011153)1.84121764
84Absent septum pellucidum (HP:0001331)1.79101169
85Increased serum lactate (HP:0002151)1.78841498
86Partial duplication of thumb phalanx (HP:0009944)1.78615911
87Aplasia/Hypoplasia of the tibia (HP:0005772)1.77827654
88Septo-optic dysplasia (HP:0100842)1.77688451
89Abnormality of the metopic suture (HP:0005556)1.77395515
90Short tibia (HP:0005736)1.76843322
91Stenosis of the external auditory canal (HP:0000402)1.76324734
92Type II lissencephaly (HP:0007260)1.73617141
93Sclerocornea (HP:0000647)1.73435672
94Increased muscle lipid content (HP:0009058)1.73059652
95Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72524689
96Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.69175794
97Absent eyebrow (HP:0002223)1.68989139
98Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.68937030
99Exertional dyspnea (HP:0002875)1.68719862
100Neoplasm of the colon (HP:0100273)1.68514778

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK167.28648088
2PAK44.65860429
3WNK33.72256708
4MAP4K23.21214267
5WNK43.16217749
6CASK3.02437038
7TLK12.73404678
8SIK22.62590833
9MAP3K122.57556891
10BCR2.32564557
11PDK22.22771339
12FRK2.06853594
13DYRK22.04150813
14INSRR1.61683120
15STK391.60320164
16SRPK11.52243190
17MARK11.47698125
18MAP2K71.44641525
19TSSK61.43240429
20NTRK21.42008983
21BCKDK1.33601109
22NUAK11.29642835
23CCNB11.23979682
24PAK31.21932770
25PHKG21.14444822
26PHKG11.14444822
27GRK11.03678293
28NEK11.03269250
29CDK81.00347069
30DAPK20.97699207
31MAPKAPK50.89908864
32CSNK1G20.86738186
33MAP3K40.85579323
34TRIM280.84749634
35EPHA40.83408898
36CAMK10.82000130
37PIK3CA0.81941279
38MAPK130.80786726
39VRK10.79484106
40CSNK2A20.78075655
41BMPR1B0.77884884
42RPS6KA50.77376597
43CSNK1D0.75949808
44CSNK1G30.74914013
45NEK20.71275155
46PASK0.69836783
47CSNK1A1L0.69388488
48RAF10.69153562
49MAP2K40.68556541
50WNK10.66774301
51MKNK20.64982365
52MKNK10.64078004
53CSNK1G10.63315050
54CSNK1E0.63158372
55TEC0.58573002
56PLK40.58528432
57TAOK20.57637551
58ALK0.57252007
59STK40.55003864
60FGFR10.54945464
61ZAK0.53985065
62ACVR1B0.53033337
63ADRBK20.51591888
64PRKCG0.51105149
65TIE10.48621069
66RIPK40.47645868
67DYRK1A0.43391862
68TGFBR10.43073442
69CDC70.42308808
70IKBKB0.41263807
71ATR0.40117461
72PRKCI0.40053951
73AURKB0.39150983
74VRK20.37539932
75NME10.35126465
76MAPK120.34827960
77CDK50.34043139
78WEE10.33631242
79ABL20.33226994
80ILK0.31791160
81CSNK1A10.31303768
82CAMK2A0.31154462
83MAP3K110.30730510
84MARK20.30729394
85PRKACB0.30309212
86OXSR10.29756179
87PRKACA0.28581205
88OBSCN0.27652314
89CSNK2A10.26959404
90MAP3K90.26378572
91CHEK10.26050768
92PIM20.25743644
93DAPK30.25434032
94PRKCB0.25304773
95ATM0.25023692
96BUB10.24787976
97PLK30.24390598
98ADRBK10.24353539
99PRKAA10.24094861
100IKBKE0.23695192

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.95522485
2Oxidative phosphorylation_Homo sapiens_hsa001904.01506970
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.50833802
4Mismatch repair_Homo sapiens_hsa034303.49845056
5Parkinsons disease_Homo sapiens_hsa050123.39397741
6Vitamin B6 metabolism_Homo sapiens_hsa007502.85567917
7Nicotine addiction_Homo sapiens_hsa050332.81132152
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.79597330
9Protein export_Homo sapiens_hsa030602.70688493
10Huntingtons disease_Homo sapiens_hsa050162.48579605
11Alzheimers disease_Homo sapiens_hsa050102.37153824
12Proteasome_Homo sapiens_hsa030502.07161256
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04998198
14Asthma_Homo sapiens_hsa053102.03647925
15Cardiac muscle contraction_Homo sapiens_hsa042602.03553500
16RNA polymerase_Homo sapiens_hsa030202.01132863
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90311383
18GABAergic synapse_Homo sapiens_hsa047271.79204034
19Nucleotide excision repair_Homo sapiens_hsa034201.66535016
20RNA degradation_Homo sapiens_hsa030181.63324847
21Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.57279393
22Homologous recombination_Homo sapiens_hsa034401.54631101
23Phototransduction_Homo sapiens_hsa047441.43310786
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42959651
25Taste transduction_Homo sapiens_hsa047421.35753980
26Basal transcription factors_Homo sapiens_hsa030221.34467133
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.28559277
28RNA transport_Homo sapiens_hsa030131.27289250
29Autoimmune thyroid disease_Homo sapiens_hsa053201.16085322
30Allograft rejection_Homo sapiens_hsa053301.11467410
31Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09475663
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04421045
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.02371106
34Spliceosome_Homo sapiens_hsa030400.99088972
35Pyrimidine metabolism_Homo sapiens_hsa002400.95485703
36Morphine addiction_Homo sapiens_hsa050320.90987516
37Maturity onset diabetes of the young_Homo sapiens_hsa049500.90889230
38Systemic lupus erythematosus_Homo sapiens_hsa053220.88033952
39Linoleic acid metabolism_Homo sapiens_hsa005910.87423663
40One carbon pool by folate_Homo sapiens_hsa006700.87394056
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85991274
42Glutamatergic synapse_Homo sapiens_hsa047240.79521970
43Synaptic vesicle cycle_Homo sapiens_hsa047210.76561701
44DNA replication_Homo sapiens_hsa030300.73936857
45Serotonergic synapse_Homo sapiens_hsa047260.71311165
46Peroxisome_Homo sapiens_hsa041460.70820899
47Arginine biosynthesis_Homo sapiens_hsa002200.70688649
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70680119
49Axon guidance_Homo sapiens_hsa043600.67016304
50T cell receptor signaling pathway_Homo sapiens_hsa046600.66980790
51Primary immunodeficiency_Homo sapiens_hsa053400.66436644
52Base excision repair_Homo sapiens_hsa034100.65557417
53SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65459279
54Collecting duct acid secretion_Homo sapiens_hsa049660.64924839
55Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63767052
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63256564
57Rheumatoid arthritis_Homo sapiens_hsa053230.62976332
58Purine metabolism_Homo sapiens_hsa002300.58107138
59Alcoholism_Homo sapiens_hsa050340.57647833
60Fanconi anemia pathway_Homo sapiens_hsa034600.56887379
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56715517
62Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55916762
63Non-homologous end-joining_Homo sapiens_hsa034500.55289730
64Pyruvate metabolism_Homo sapiens_hsa006200.54206379
65Steroid biosynthesis_Homo sapiens_hsa001000.52930815
66Viral myocarditis_Homo sapiens_hsa054160.52340113
67Cholinergic synapse_Homo sapiens_hsa047250.46249098
68Cocaine addiction_Homo sapiens_hsa050300.44574868
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.43604659
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42800752
71Circadian entrainment_Homo sapiens_hsa047130.41545704
72Vitamin digestion and absorption_Homo sapiens_hsa049770.40771826
73Metabolic pathways_Homo sapiens_hsa011000.39825445
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.38620886
75Sulfur relay system_Homo sapiens_hsa041220.36907815
76Amphetamine addiction_Homo sapiens_hsa050310.34006254
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.33777654
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32581655
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32456689
80Colorectal cancer_Homo sapiens_hsa052100.31831870
81Arachidonic acid metabolism_Homo sapiens_hsa005900.29757210
82Arginine and proline metabolism_Homo sapiens_hsa003300.29436414
83Dopaminergic synapse_Homo sapiens_hsa047280.28901952
84Ether lipid metabolism_Homo sapiens_hsa005650.28351408
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27967026
86Ras signaling pathway_Homo sapiens_hsa040140.27699039
87Type I diabetes mellitus_Homo sapiens_hsa049400.27343198
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27084445
89Oxytocin signaling pathway_Homo sapiens_hsa049210.26806237
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25769269
91Caffeine metabolism_Homo sapiens_hsa002320.24249375
92Propanoate metabolism_Homo sapiens_hsa006400.23738155
93Chemical carcinogenesis_Homo sapiens_hsa052040.23477583
94Graft-versus-host disease_Homo sapiens_hsa053320.22313440
95Renal cell carcinoma_Homo sapiens_hsa052110.21651708
96Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.21154887
97Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.17885803
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.17692660
99N-Glycan biosynthesis_Homo sapiens_hsa005100.15562734
100ErbB signaling pathway_Homo sapiens_hsa040120.15116235

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