ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	retinal cone cell development (GO:0046549)	5.31270851
2	lysine metabolic process (GO:0006553)	4.57975784
3	lysine catabolic process (GO:0006554)	4.57975784
4	nucleotide transmembrane transport (GO:1901679)	4.43435779
5	rRNA modification (GO:0000154)	4.36599078
6	postsynaptic membrane organization (GO:0001941)	4.33690811
7	presynaptic membrane assembly (GO:0097105)	4.30112319
8	cellular response to interferon-beta (GO:0035458)	4.26043406
9	vocalization behavior (GO:0071625)	4.24083848
10	alkaloid metabolic process (GO:0009820)	4.17038480
11	lipopolysaccharide biosynthetic process (GO:0009103)	4.14774040
12	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	4.06985708
13	regulation of mitotic spindle checkpoint (GO:1903504)	4.06985708
14	signal peptide processing (GO:0006465)	4.03259139
15	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	4.00648131
16	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.99206571
17	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.99206571
18	NADH dehydrogenase complex assembly (GO:0010257)	3.99206571
19	rRNA methylation (GO:0031167)	3.97946462
20	maturation of SSU-rRNA (GO:0030490)	3.95351020
21	proteasome assembly (GO:0043248)	3.90500982
22	protein complex biogenesis (GO:0070271)	3.80683703
23	water-soluble vitamin biosynthetic process (GO:0042364)	3.73554929
24	presynaptic membrane organization (GO:0097090)	3.64367299
25	mitochondrial respiratory chain complex assembly (GO:0033108)	3.60856619
26	positive regulation of potassium ion transmembrane transporter activity (GO:1901018)	3.57523569
27	xenobiotic catabolic process (GO:0042178)	3.56788055
28	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.55168608
29	isotype switching (GO:0045190)	3.55168608
30	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.55168608
31	DNA deamination (GO:0045006)	3.43386550
32	replication fork processing (GO:0031297)	3.40759983
33	synaptic transmission, cholinergic (GO:0007271)	3.40613569
34	lipopolysaccharide metabolic process (GO:0008653)	3.39908778
35	protein neddylation (GO:0045116)	3.36895049
36	ribosomal small subunit biogenesis (GO:0042274)	3.34608553
37	pseudouridine synthesis (GO:0001522)	3.28512387
38	GTP biosynthetic process (GO:0006183)	3.26925972
39	chaperone-mediated protein transport (GO:0072321)	3.26198514
40	regulation of immunoglobulin secretion (GO:0051023)	3.22236065
41	negative regulation of complement activation (GO:0045916)	3.14607196
42	DNA damage response, detection of DNA damage (GO:0042769)	3.13731653
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.12519331
44	amyloid precursor protein catabolic process (GO:0042987)	3.11847730
45	motile cilium assembly (GO:0044458)	3.11318255
46	cellular component biogenesis (GO:0044085)	3.08131402
47	regulation of penile erection (GO:0060405)	3.08116585
48	translational termination (GO:0006415)	3.06355159
49	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	3.05447792
50	response to folic acid (GO:0051593)	3.04856107
51	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.04655611
52	behavioral response to nicotine (GO:0035095)	3.03149162
53	ribosome biogenesis (GO:0042254)	3.02723805
54	positive regulation of mitochondrial fission (GO:0090141)	3.00897324
55	ribonucleoprotein complex biogenesis (GO:0022613)	3.00194931
56	cellular biogenic amine catabolic process (GO:0042402)	2.99606031
57	amine catabolic process (GO:0009310)	2.99606031
58	maturation of 5.8S rRNA (GO:0000460)	2.99541792
59	rRNA catabolic process (GO:0016075)	2.99080514
60	aspartate family amino acid catabolic process (GO:0009068)	2.98208873
61	viral transcription (GO:0019083)	2.95607962
62	neurotransmitter-gated ion channel clustering (GO:0072578)	2.92447465
63	GPI anchor metabolic process (GO:0006505)	2.91301071
64	UTP biosynthetic process (GO:0006228)	2.86512707
65	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.85507111
66	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.81293995
67	neuron cell-cell adhesion (GO:0007158)	2.78536358
68	ncRNA catabolic process (GO:0034661)	2.76435623
69	ribosomal large subunit biogenesis (GO:0042273)	2.75987731
70	somatic diversification of immunoglobulins (GO:0016445)	2.75758933
71	resolution of meiotic recombination intermediates (GO:0000712)	2.75198947
72	retinal ganglion cell axon guidance (GO:0031290)	2.74595792
73	positive regulation of synapse assembly (GO:0051965)	2.74517413
74	Notch receptor processing (GO:0007220)	2.74259384
75	somatic recombination of immunoglobulin gene segments (GO:0016447)	2.72545025
76	protein heterotetramerization (GO:0051290)	2.72396260
77	cotranslational protein targeting to membrane (GO:0006613)	2.72179388
78	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.72162672
79	response to interferon-beta (GO:0035456)	2.72111157
80	negative regulation of protein activation cascade (GO:2000258)	2.71262611
81	coenzyme catabolic process (GO:0009109)	2.70933250
82	preassembly of GPI anchor in ER membrane (GO:0016254)	2.70155928
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.69930825
84	response to magnesium ion (GO:0032026)	2.68895548
85	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.68834595
86	guanosine-containing compound biosynthetic process (GO:1901070)	2.68639571
87	auditory receptor cell differentiation (GO:0042491)	2.68529010
88	amino-acid betaine metabolic process (GO:0006577)	2.68256703
89	cytochrome complex assembly (GO:0017004)	2.66487100
90	protein localization to mitochondrion (GO:0070585)	2.65567389
91	sulfation (GO:0051923)	2.65511588
92	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.65503009
93	establishment of protein localization to mitochondrion (GO:0072655)	2.65382192
94	nucleotide transport (GO:0006862)	2.65132715
95	protein targeting to ER (GO:0045047)	2.62772928
96	regulation of heat generation (GO:0031650)	2.62736079
97	sulfur amino acid catabolic process (GO:0000098)	2.61413959
98	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.60948811
99	protein targeting to mitochondrion (GO:0006626)	2.59892440
100	platelet dense granule organization (GO:0060155)	2.58438507

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	3.92975207
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.50584736
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.40051541
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.05390727
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.98721412
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.89218411
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.68488282
8	IRF1_19129219_ChIP-ChIP_H3396_Human	2.64469923
9	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.47260216
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.31924120
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.17679106
12	FUS_26573619_Chip-Seq_HEK293_Human	2.11010327
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10870443
14	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.03652923
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.01173869
16	MYC_18940864_ChIP-ChIP_HL60_Human	1.99735045
17	ELK1_19687146_ChIP-ChIP_HELA_Human	1.99441608
18	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96348477
19	VDR_22108803_ChIP-Seq_LS180_Human	1.96308721
20	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.91410161
21	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.90344892
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.90012791
23	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.81182837
24	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.81070508
25	EWS_26573619_Chip-Seq_HEK293_Human	1.79022926
26	P300_19829295_ChIP-Seq_ESCs_Human	1.74722354
27	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.72177533
28	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.68871621
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.68547544
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.68296838
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.63876586
32	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.62666574
33	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.60586491
34	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.59901387
35	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53499202
36	EZH2_22144423_ChIP-Seq_EOC_Human	1.52899539
37	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50981071
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50213551
39	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47305693
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42604379
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.42505580
42	TAF15_26573619_Chip-Seq_HEK293_Human	1.41936469
43	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.40164342
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35944965
45	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.35254831
46	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34977144
47	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.34065282
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32022609
49	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.31522039
50	TTF2_22483619_ChIP-Seq_HELA_Human	1.28460081
51	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.26084263
52	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.25263006
53	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.24218671
54	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22897444
55	TP53_22573176_ChIP-Seq_HFKS_Human	1.21113222
56	AR_21572438_ChIP-Seq_LNCaP_Human	1.20772434
57	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.17918904
58	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.17854437
59	STAT3_23295773_ChIP-Seq_U87_Human	1.16138815
60	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.15729875
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.14238794
62	TCF4_22108803_ChIP-Seq_LS180_Human	1.12296435
63	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.12086044
64	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.11083728
65	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10662655
66	FOXP3_21729870_ChIP-Seq_TREG_Human	1.08672783
67	RNF2_27304074_Chip-Seq_NSC_Mouse	1.08201132
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08146490
69	AR_25329375_ChIP-Seq_VCAP_Human	1.08092640
70	AR_20517297_ChIP-Seq_VCAP_Human	1.08064928
71	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.08000338
72	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.08000338
73	MYC_19829295_ChIP-Seq_ESCs_Human	1.07922409
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07654452
75	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06021631
76	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03527700
77	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03527700
78	CBP_20019798_ChIP-Seq_JUKART_Human	1.02509716
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.02509716
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.01419048
81	NCOR_22424771_ChIP-Seq_293T_Human	1.01246226
82	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.00240857
83	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.99592668
84	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.99215119
85	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99142847
86	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99142847
87	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.99132043
88	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98948204
89	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98090782
90	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.97680222
91	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97518704
92	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.95753799
93	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95664667
94	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95635859
95	BCAT_22108803_ChIP-Seq_LS180_Human	0.95134708
96	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.93524776
97	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.93278884
98	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.92649287
99	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.92034124
100	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.92020501

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	5.56580393
2	MP0002638_abnormal_pupillary_reflex	4.74284428
3	MP0003329_amyloid_beta_deposits	3.09908066
4	MP0008877_abnormal_DNA_methylation	2.95285703
5	MP0003011_delayed_dark_adaptation	2.93649793
6	MP0000579_abnormal_nail_morphology	2.89038330
7	MP0001529_abnormal_vocalization	2.72386563
8	MP0005253_abnormal_eye_physiology	2.69934098
9	MP0001661_extended_life_span	2.55586610
10	MP0006072_abnormal_retinal_apoptosis	2.38262916
11	MP0002102_abnormal_ear_morphology	2.24747819
12	MP0001502_abnormal_circadian_rhythm	2.19321913
13	MP0005551_abnormal_eye_electrophysiolog	1.98638597
14	MP0001968_abnormal_touch/_nociception	1.97642976
15	MP0003122_maternal_imprinting	1.97223979
16	MP0009053_abnormal_anal_canal	1.91685289
17	MP0000604_amyloidosis	1.90009861
18	MP0005171_absent_coat_pigmentation	1.86939059
19	MP0004142_abnormal_muscle_tone	1.86836408
20	MP0002163_abnormal_gland_morphology	1.85301563
21	MP0006292_abnormal_olfactory_placode	1.84286078
22	MP0008875_abnormal_xenobiotic_pharmacok	1.81848619
23	MP0002736_abnormal_nociception_after	1.77722256
24	MP0003195_calcinosis	1.76812896
25	MP0009046_muscle_twitch	1.76159999
26	MP0002234_abnormal_pharynx_morphology	1.68842977
27	MP0000647_abnormal_sebaceous_gland	1.66675063
28	MP0003693_abnormal_embryo_hatching	1.65289182
29	MP0000427_abnormal_hair_cycle	1.60551010
30	MP0002272_abnormal_nervous_system	1.53241734
31	MP0009379_abnormal_foot_pigmentation	1.52417018
32	MP0006276_abnormal_autonomic_nervous	1.49382224
33	MP0002095_abnormal_skin_pigmentation	1.46698884
34	MP0001293_anophthalmia	1.46411455
35	MP0006054_spinal_hemorrhage	1.46141043
36	MP0002653_abnormal_ependyma_morphology	1.43360447
37	MP0005085_abnormal_gallbladder_physiolo	1.34039846
38	MP0003632_abnormal_nervous_system	1.31061422
39	MP0009745_abnormal_behavioral_response	1.30164926
40	MP0003119_abnormal_digestive_system	1.27438792
41	MP0005391_vision/eye_phenotype	1.26571183
42	MP0003880_abnormal_central_pattern	1.25782713
43	MP0008058_abnormal_DNA_repair	1.23958779
44	MP0000049_abnormal_middle_ear	1.23140126
45	MP0000685_abnormal_immune_system	1.20438981
46	MP0002751_abnormal_autonomic_nervous	1.20018433
47	MP0005174_abnormal_tail_pigmentation	1.18840818
48	MP0005423_abnormal_somatic_nervous	1.18456979
49	MP0008007_abnormal_cellular_replicative	1.17899114
50	MP0001984_abnormal_olfaction	1.17469514
51	MP0000778_abnormal_nervous_system	1.15395020
52	MP0002909_abnormal_adrenal_gland	1.15177288
53	MP0001963_abnormal_hearing_physiology	1.14144908
54	MP0002735_abnormal_chemical_nociception	1.13897863
55	MP0002733_abnormal_thermal_nociception	1.12888281
56	MP0005195_abnormal_posterior_eye	1.09745242
57	MP0003787_abnormal_imprinting	1.09633917
58	MP0002064_seizures	1.09538672
59	MP0001970_abnormal_pain_threshold	1.08994917
60	MP0005645_abnormal_hypothalamus_physiol	1.08499945
61	MP0001986_abnormal_taste_sensitivity	1.08198387
62	MP0000631_abnormal_neuroendocrine_gland	1.08018298
63	MP0003937_abnormal_limbs/digits/tail_de	1.03573035
64	MP0003567_abnormal_fetal_cardiomyocyte	1.00211506
65	MP0001853_heart_inflammation	0.96786880
66	MP0002572_abnormal_emotion/affect_behav	0.95624364
67	MP0004147_increased_porphyrin_level	0.93691353
68	MP0000383_abnormal_hair_follicle	0.93365965
69	MP0004885_abnormal_endolymph	0.92155267
70	MP0001764_abnormal_homeostasis	0.91540047
71	MP0003121_genomic_imprinting	0.91503119
72	MP0002557_abnormal_social/conspecific_i	0.89650465
73	MP0002229_neurodegeneration	0.89363591
74	MP0006035_abnormal_mitochondrial_morpho	0.89183315
75	MP0010386_abnormal_urinary_bladder	0.87807002
76	MP0005379_endocrine/exocrine_gland_phen	0.87317385
77	MP0004043_abnormal_pH_regulation	0.87030375
78	MP0002210_abnormal_sex_determination	0.85777991
79	MP0002752_abnormal_somatic_nervous	0.84715513
80	MP0003878_abnormal_ear_physiology	0.83325830
81	MP0005377_hearing/vestibular/ear_phenot	0.83325830
82	MP0000613_abnormal_salivary_gland	0.83323554
83	MP0009384_cardiac_valve_regurgitation	0.82224785
84	MP0005367_renal/urinary_system_phenotyp	0.79712569
85	MP0000516_abnormal_urinary_system	0.79712569
86	MP0001486_abnormal_startle_reflex	0.78418505
87	MP0000026_abnormal_inner_ear	0.76076434
88	MP0002233_abnormal_nose_morphology	0.75960075
89	MP0001485_abnormal_pinna_reflex	0.74637502
90	MP0001286_abnormal_eye_development	0.74604069
91	MP0000955_abnormal_spinal_cord	0.71112790
92	MP0001929_abnormal_gametogenesis	0.70274837
93	MP0008872_abnormal_physiological_respon	0.68966610
94	MP0004133_heterotaxia	0.67817036
95	MP0001501_abnormal_sleep_pattern	0.66748931
96	MP0003890_abnormal_embryonic-extraembry	0.66312207
97	MP0000538_abnormal_urinary_bladder	0.65051620
98	MP0008873_increased_physiological_sensi	0.64925869
99	MP0000013_abnormal_adipose_tissue	0.64398201
100	MP0001145_abnormal_male_reproductive	0.64312327

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	4.89168954
2	Increased IgM level (HP:0003496)	4.52696341
3	Septo-optic dysplasia (HP:0100842)	4.29350167
4	Reticulocytopenia (HP:0001896)	3.89754601
5	3-Methylglutaconic aciduria (HP:0003535)	3.51539029
6	Acute necrotizing encephalopathy (HP:0006965)	3.34451174
7	Pancreatic cysts (HP:0001737)	3.32791400
8	Coronal craniosynostosis (HP:0004440)	3.31755739
9	Absent phalangeal crease (HP:0006109)	3.31187512
10	Congenital, generalized hypertrichosis (HP:0004540)	3.27136882
11	Bile duct proliferation (HP:0001408)	3.27024085
12	Abnormal biliary tract physiology (HP:0012439)	3.27024085
13	Pendular nystagmus (HP:0012043)	3.26832683
14	Abnormal finger flexion creases (HP:0006143)	3.20494522
15	Acute encephalopathy (HP:0006846)	3.11822410
16	True hermaphroditism (HP:0010459)	3.09638841
17	Pancreatic fibrosis (HP:0100732)	3.08827848
18	Absent septum pellucidum (HP:0001331)	2.98139755
19	Methylmalonic aciduria (HP:0012120)	2.93078807
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86328334
21	Confusion (HP:0001289)	2.85744935
22	Short 5th finger (HP:0009237)	2.83467742
23	Optic nerve hypoplasia (HP:0000609)	2.75244350
24	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	2.74687436
25	Progressive macrocephaly (HP:0004481)	2.73681745
26	Hyperglycinemia (HP:0002154)	2.72724567
27	Polyphagia (HP:0002591)	2.67361751
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65721942
29	Broad foot (HP:0001769)	2.64026614
30	Follicular hyperkeratosis (HP:0007502)	2.62730328
31	Optic disc pallor (HP:0000543)	2.61888376
32	Conjunctival telangiectasia (HP:0000524)	2.58360025
33	Abnormality of binocular vision (HP:0011514)	2.55171309
34	Diplopia (HP:0000651)	2.55171309
35	Abnormality of the septum pellucidum (HP:0007375)	2.53431406
36	Chronic hepatic failure (HP:0100626)	2.53193247
37	Mitochondrial inheritance (HP:0001427)	2.51928310
38	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.50305221
39	Decreased central vision (HP:0007663)	2.49186650
40	Agitation (HP:0000713)	2.48222612
41	Congenital stationary night blindness (HP:0007642)	2.47162882
42	Nephronophthisis (HP:0000090)	2.46070719
43	Spastic paraparesis (HP:0002313)	2.42935861
44	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.42307837
45	Status epilepticus (HP:0002133)	2.41224544
46	Abnormality of midbrain morphology (HP:0002418)	2.39663661
47	Molar tooth sign on MRI (HP:0002419)	2.39663661
48	IgA deficiency (HP:0002720)	2.37458771
49	Large for gestational age (HP:0001520)	2.35924371
50	Colon cancer (HP:0003003)	2.33341058
51	Poor head control (HP:0002421)	2.32747412
52	Occipital encephalocele (HP:0002085)	2.28462238
53	Methylmalonic acidemia (HP:0002912)	2.28389245
54	Abnormality of the renal medulla (HP:0100957)	2.28210996
55	Increased CSF lactate (HP:0002490)	2.22303340
56	Macrocytic anemia (HP:0001972)	2.21954395
57	Medial flaring of the eyebrow (HP:0010747)	2.21486282
58	Thyroid-stimulating hormone excess (HP:0002925)	2.19095162
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.16288381
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.16288381
61	Cerebral edema (HP:0002181)	2.13303108
62	Hemiparesis (HP:0001269)	2.11877188
63	Sclerocornea (HP:0000647)	2.11870626
64	Generalized myoclonic seizures (HP:0002123)	2.10941300
65	Respiratory distress (HP:0002098)	2.09734334
66	Anterior segment dysgenesis (HP:0007700)	2.08824696
67	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.08487803
68	Hypoplasia of the fovea (HP:0007750)	2.08487803
69	Pili torti (HP:0003777)	2.06515811
70	Inability to walk (HP:0002540)	2.05786129
71	Abnormal rod and cone electroretinograms (HP:0008323)	2.05438125
72	Abolished electroretinogram (ERG) (HP:0000550)	2.03525652
73	Abnormality of the renal cortex (HP:0011035)	2.01708338
74	Blindness (HP:0000618)	2.00770514
75	Tubular atrophy (HP:0000092)	1.99524999
76	Postural tremor (HP:0002174)	1.98435058
77	Generalized tonic-clonic seizures (HP:0002069)	1.97930982
78	Focal seizures (HP:0007359)	1.96353043
79	Maternal diabetes (HP:0009800)	1.93387395
80	Abnormality of the vasculature of the conjunctiva (HP:0008054)	1.90876088
81	Chorioretinal atrophy (HP:0000533)	1.88998269
82	Mesangial abnormality (HP:0001966)	1.88398178
83	Abnormality of serine family amino acid metabolism (HP:0010894)	1.87322751
84	Abnormality of glycine metabolism (HP:0010895)	1.87322751
85	Meckel diverticulum (HP:0002245)	1.83029779
86	Gait imbalance (HP:0002141)	1.81575433
87	J-shaped sella turcica (HP:0002680)	1.81395229
88	Birth length less than 3rd percentile (HP:0003561)	1.79154739
89	Abnormality of the ileum (HP:0001549)	1.79099479
90	IgG deficiency (HP:0004315)	1.78658039
91	Cystic liver disease (HP:0006706)	1.78515084
92	Congenital primary aphakia (HP:0007707)	1.77096405
93	Neonatal respiratory distress (HP:0002643)	1.76475958
94	Anencephaly (HP:0002323)	1.75691540
95	Horizontal nystagmus (HP:0000666)	1.75281130
96	Abnormality of the anterior chamber (HP:0000593)	1.74355398
97	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.73094198
98	Woolly hair (HP:0002224)	1.71722508
99	Secondary amenorrhea (HP:0000869)	1.71716113
100	CNS hypomyelination (HP:0003429)	1.71273291

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK2	3.14006209
2	INSRR	3.08535511
3	TSSK6	3.07030037
4	CASK	3.05216271
5	MAP4K2	2.74792643
6	CDC7	2.52581184
7	WNK3	2.46384556
8	PNCK	2.45370371
9	PINK1	2.35002964
10	ZAK	2.34804878
11	WNK4	2.34505486
12	EPHA4	2.28747438
13	EIF2AK3	2.16722375
14	MAPK15	2.16045921
15	DYRK2	2.13924621
16	GRK1	2.09177041
17	STK38L	2.05355927
18	TNIK	1.90761202
19	MUSK	1.74201389
20	PDK2	1.74163352
21	EIF2AK1	1.73801879
22	MKNK1	1.72351864
23	BMPR1B	1.71296550
24	SRPK1	1.71092674
25	CSNK1G3	1.70393604
26	VRK1	1.64013075
27	ADRBK2	1.60583636
28	FRK	1.56436945
29	PLK3	1.54267341
30	TRIM28	1.52103200
31	PAK3	1.43833067
32	CSNK1G2	1.43104943
33	CSNK1A1L	1.38953847
34	CSNK1G1	1.37607757
35	STK39	1.33707930
36	PLK2	1.29907353
37	VRK2	1.26565911
38	NUAK1	1.22718862
39	BRD4	1.22526789
40	NTRK2	1.18420565
41	PHKG2	1.15311623
42	PHKG1	1.15311623
43	GRK5	1.01829708
44	PLK4	1.00103326
45	WEE1	0.94627209
46	RPS6KA4	0.92678155
47	DYRK1A	0.91582595
48	PIK3CA	0.84520279
49	CDK8	0.84153671
50	TXK	0.81594451
51	PTK2B	0.76750562
52	RPS6KA5	0.76116437
53	MOS	0.73538479
54	PRKCG	0.67355495
55	JAK3	0.67215549
56	GRK7	0.66380859
57	STK16	0.65708168
58	PLK1	0.63024932
59	EPHB2	0.62317793
60	TAOK3	0.62042730
61	WNK1	0.58293800
62	ATR	0.57364899
63	BCKDK	0.54688577
64	NEK6	0.54341206
65	PRKCE	0.53220523
66	BMX	0.52761980
67	TGFBR1	0.51960974
68	MAPK7	0.51837474
69	CDK7	0.50509044
70	AURKB	0.46419323
71	CSNK1A1	0.42343775
72	CHEK2	0.41416788
73	MARK3	0.41361168
74	FGR	0.40334242
75	PRKCI	0.40102137
76	CAMK2A	0.39934106
77	EIF2AK2	0.37243611
78	CSNK1E	0.36585999
79	IKBKE	0.36511801
80	ADRBK1	0.36433203
81	CSNK2A1	0.36349664
82	PRKACA	0.35935355
83	CSNK2A2	0.32267034
84	BUB1	0.31869867
85	PRKCZ	0.30445041
86	MAPKAPK5	0.30365646
87	PIK3CG	0.29580704
88	TEC	0.28203461
89	PRKDC	0.27831144
90	LRRK2	0.27802431
91	FGFR1	0.26691292
92	MAPK13	0.26616836
93	CSNK1D	0.25616768
94	AURKA	0.25242024
95	CDK3	0.25230548
96	TYK2	0.24724078
97	BCR	0.24636521
98	DAPK3	0.24521089
99	MARK1	0.22742197
100	MAP3K11	0.22183556

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin B6 metabolism_Homo sapiens_hsa00750	4.10578044
2	Ribosome_Homo sapiens_hsa03010	3.19740582
3	One carbon pool by folate_Homo sapiens_hsa00670	2.97906420
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.77526237
5	beta-Alanine metabolism_Homo sapiens_hsa00410	2.28810964
6	Caffeine metabolism_Homo sapiens_hsa00232	2.23862814
7	Parkinsons disease_Homo sapiens_hsa05012	2.23390401
8	Protein export_Homo sapiens_hsa03060	2.15903535
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.08542470
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.07066902
11	Proteasome_Homo sapiens_hsa03050	2.06972224
12	Glycerolipid metabolism_Homo sapiens_hsa00561	1.99864700
13	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.95577853
14	Sulfur metabolism_Homo sapiens_hsa00920	1.93772379
15	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.88107628
16	RNA polymerase_Homo sapiens_hsa03020	1.85804092
17	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.78174102
18	Tryptophan metabolism_Homo sapiens_hsa00380	1.64797396
19	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.55463030
20	Propanoate metabolism_Homo sapiens_hsa00640	1.50181260
21	Histidine metabolism_Homo sapiens_hsa00340	1.46081870
22	Huntingtons disease_Homo sapiens_hsa05016	1.45613173
23	Arginine and proline metabolism_Homo sapiens_hsa00330	1.45393664
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.45041724
25	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.39021197
26	Alzheimers disease_Homo sapiens_hsa05010	1.38871853
27	Fatty acid elongation_Homo sapiens_hsa00062	1.38526646
28	Mismatch repair_Homo sapiens_hsa03430	1.34908908
29	Basal cell carcinoma_Homo sapiens_hsa05217	1.30062190
30	Collecting duct acid secretion_Homo sapiens_hsa04966	1.29858192
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28782249
32	Linoleic acid metabolism_Homo sapiens_hsa00591	1.28751190
33	Nicotine addiction_Homo sapiens_hsa05033	1.22120835
34	Fanconi anemia pathway_Homo sapiens_hsa03460	1.21391241
35	Fatty acid degradation_Homo sapiens_hsa00071	1.20731445
36	Homologous recombination_Homo sapiens_hsa03440	1.17427768
37	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.16703403
38	RNA degradation_Homo sapiens_hsa03018	1.15821224
39	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.15429762
40	Phototransduction_Homo sapiens_hsa04744	1.14454905
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.12309171
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.12290861
43	Steroid biosynthesis_Homo sapiens_hsa00100	1.07072255
44	Taste transduction_Homo sapiens_hsa04742	1.07049077
45	Butanoate metabolism_Homo sapiens_hsa00650	1.05115285
46	Basal transcription factors_Homo sapiens_hsa03022	1.04111686
47	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.04044196
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.03231089
49	Olfactory transduction_Homo sapiens_hsa04740	1.02924519
50	Cardiac muscle contraction_Homo sapiens_hsa04260	1.02147047
51	Glutathione metabolism_Homo sapiens_hsa00480	1.01344039
52	Nitrogen metabolism_Homo sapiens_hsa00910	1.00856593
53	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98017043
54	ABC transporters_Homo sapiens_hsa02010	0.96487267
55	Pyruvate metabolism_Homo sapiens_hsa00620	0.95698232
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.95626821
57	Pyrimidine metabolism_Homo sapiens_hsa00240	0.95454092
58	Lysine degradation_Homo sapiens_hsa00310	0.94751399
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.86985760
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.82375391
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.79741772
62	Base excision repair_Homo sapiens_hsa03410	0.79219140
63	Metabolic pathways_Homo sapiens_hsa01100	0.77862149
64	Asthma_Homo sapiens_hsa05310	0.77342873
65	GABAergic synapse_Homo sapiens_hsa04727	0.73624742
66	Purine metabolism_Homo sapiens_hsa00230	0.73617665
67	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72909635
68	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.72331198
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70946984
70	Retinol metabolism_Homo sapiens_hsa00830	0.70537494
71	DNA replication_Homo sapiens_hsa03030	0.69676598
72	Spliceosome_Homo sapiens_hsa03040	0.67318903
73	Peroxisome_Homo sapiens_hsa04146	0.67120609
74	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.66384104
75	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.65982606
76	Sulfur relay system_Homo sapiens_hsa04122	0.65726151
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.63465798
78	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.63455269
79	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.63441750
80	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62382474
81	Ether lipid metabolism_Homo sapiens_hsa00565	0.58623278
82	RNA transport_Homo sapiens_hsa03013	0.57305459
83	Selenocompound metabolism_Homo sapiens_hsa00450	0.53191845
84	Primary immunodeficiency_Homo sapiens_hsa05340	0.51485218
85	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48788703
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.48528708
87	Fatty acid metabolism_Homo sapiens_hsa01212	0.46102826
88	Allograft rejection_Homo sapiens_hsa05330	0.44311385
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.43880882
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.43617235
91	Circadian rhythm_Homo sapiens_hsa04710	0.42652860
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.42278403
93	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41276690
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40417036
95	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.39493584
96	Bile secretion_Homo sapiens_hsa04976	0.36710241
97	Morphine addiction_Homo sapiens_hsa05032	0.35279175
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34010006
99	Serotonergic synapse_Homo sapiens_hsa04726	0.33057772
100	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33000366

RPL7AP25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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