ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.97491441
2	maturation of SSU-rRNA (GO:0030490)	6.34568232
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.17217449
4	viral transcription (GO:0019083)	5.93011551
5	translational termination (GO:0006415)	5.73909413
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.53746310
7	ATP synthesis coupled proton transport (GO:0015986)	5.53746310
8	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.31646356
9	cotranslational protein targeting to membrane (GO:0006613)	5.24772064
10	protein targeting to ER (GO:0045047)	5.22726140
11	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.04557661
12	response to pheromone (GO:0019236)	5.00792956
13	translational elongation (GO:0006414)	5.00759754
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.98762583
15	protein localization to endoplasmic reticulum (GO:0070972)	4.92805176
16	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.74173939
17	respiratory electron transport chain (GO:0022904)	4.61718349
18	electron transport chain (GO:0022900)	4.59652328
19	protein neddylation (GO:0045116)	4.59422370
20	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.51551353
21	ribosomal small subunit biogenesis (GO:0042274)	4.50095660
22	viral life cycle (GO:0019058)	4.46156975
23	sequestering of actin monomers (GO:0042989)	4.42855513
24	protein complex biogenesis (GO:0070271)	4.41160081
25	DNA deamination (GO:0045006)	4.35963440
26	cellular protein complex disassembly (GO:0043624)	4.33712225
27	cytidine deamination (GO:0009972)	4.25883777
28	cytidine metabolic process (GO:0046087)	4.25883777
29	cytidine catabolic process (GO:0006216)	4.25883777
30	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.18552003
31	platelet dense granule organization (GO:0060155)	4.14571969
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.12360747
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.12360747
34	NADH dehydrogenase complex assembly (GO:0010257)	4.12360747
35	translational initiation (GO:0006413)	4.05929745
36	mitochondrial respiratory chain complex assembly (GO:0033108)	4.05252246
37	GPI anchor metabolic process (GO:0006505)	3.82133433
38	GPI anchor biosynthetic process (GO:0006506)	3.67086633
39	translation (GO:0006412)	3.60974025
40	rRNA modification (GO:0000154)	3.56754561
41	protein complex disassembly (GO:0043241)	3.53714789
42	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.53458378
43	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.53458378
44	mannosylation (GO:0097502)	3.53177212
45	ATP biosynthetic process (GO:0006754)	3.49257806
46	macromolecular complex disassembly (GO:0032984)	3.44973559
47	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.44475721
48	negative regulation by host of viral transcription (GO:0043922)	3.40263237
49	protein targeting to membrane (GO:0006612)	3.39212972
50	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.35408799
51	preassembly of GPI anchor in ER membrane (GO:0016254)	3.32313714
52	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.20057505
53	ribosomal large subunit biogenesis (GO:0042273)	3.17626579
54	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.16541701
55	cellular component biogenesis (GO:0044085)	3.14774411
56	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.08808708
57	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.07514296
58	proteasome assembly (GO:0043248)	3.04878041
59	hydrogen ion transmembrane transport (GO:1902600)	3.04588964
60	regulation of cellular amino acid metabolic process (GO:0006521)	3.00166062
61	rRNA methylation (GO:0031167)	2.97829869
62	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.97616701
63	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.97419562
64	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.95489575
65	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.90942551
66	mRNA catabolic process (GO:0006402)	2.88657868
67	chaperone-mediated protein transport (GO:0072321)	2.87952411
68	inner mitochondrial membrane organization (GO:0007007)	2.87852681
69	cullin deneddylation (GO:0010388)	2.85471344
70	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.85434898
71	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.85434898
72	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.85434898
73	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.83761727
74	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.83761727
75	water-soluble vitamin biosynthetic process (GO:0042364)	2.82568164
76	ribonucleoprotein complex biogenesis (GO:0022613)	2.81866556
77	deoxyribose phosphate catabolic process (GO:0046386)	2.81175903
78	proton transport (GO:0015992)	2.80826378
79	iron-sulfur cluster assembly (GO:0016226)	2.80254720
80	metallo-sulfur cluster assembly (GO:0031163)	2.80254720
81	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.79471312
82	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.77686971
83	termination of RNA polymerase III transcription (GO:0006386)	2.77686971
84	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.76448266
85	hydrogen transport (GO:0006818)	2.75492238
86	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.75182938
87	cellular ketone body metabolic process (GO:0046950)	2.74495827
88	respiratory chain complex IV assembly (GO:0008535)	2.71256090
89	ketone body metabolic process (GO:1902224)	2.69544867
90	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.67407742
91	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.67380998
92	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.67380998
93	nucleoside triphosphate biosynthetic process (GO:0009142)	2.66513566
94	oxidative phosphorylation (GO:0006119)	2.66325782
95	actin nucleation (GO:0045010)	2.65572341
96	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.64761935
97	deoxyribonucleotide catabolic process (GO:0009264)	2.60782749
98	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.57581001
99	negative regulation of ligase activity (GO:0051352)	2.57581001
100	regulation of activation of Janus kinase activity (GO:0010533)	2.56568035

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	6.25346990
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.25769929
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.79749042
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.61643340
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.41655990
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.24823251
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.19663012
8	ZNF274_21170338_ChIP-Seq_K562_Hela	3.03905582
9	VDR_22108803_ChIP-Seq_LS180_Human	2.69474602
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.60773459
11	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.51940302
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.40518526
13	ELK1_19687146_ChIP-ChIP_HELA_Human	2.35166870
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.18885967
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.12479592
16	MYC_18940864_ChIP-ChIP_HL60_Human	2.10590275
17	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.08250249
18	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.02608064
19	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95977384
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.92838423
21	FUS_26573619_Chip-Seq_HEK293_Human	1.89120986
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.84277900
23	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.81046284
24	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.75252430
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.64034071
26	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.63457590
27	EWS_26573619_Chip-Seq_HEK293_Human	1.61450115
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.57216398
29	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.51184061
30	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.42877643
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.41816583
32	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38368001
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36871848
34	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.36077805
35	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.35735719
36	P300_19829295_ChIP-Seq_ESCs_Human	1.34431716
37	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.34376626
38	AR_20517297_ChIP-Seq_VCAP_Human	1.31468326
39	ER_23166858_ChIP-Seq_MCF-7_Human	1.31157204
40	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.31066536
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.28815011
42	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.27399635
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.26809781
44	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.26809781
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.26182159
46	GABP_19822575_ChIP-Seq_HepG2_Human	1.25692985
47	TTF2_22483619_ChIP-Seq_HELA_Human	1.23157682
48	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.22847089
49	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.21774980
50	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.21740981
51	ERG_20517297_ChIP-Seq_VCAP_Human	1.20083002
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17692644
53	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17692644
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.17277958
55	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.17127087
56	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12608571
57	DCP1A_22483619_ChIP-Seq_HELA_Human	1.12119785
58	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.11902475
59	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.10449934
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.10357531
61	NCOR_22424771_ChIP-Seq_293T_Human	1.10133610
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.08597028
63	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.07825254
64	XRN2_22483619_ChIP-Seq_HELA_Human	1.07677864
65	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07614187
66	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.07064087
67	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.07003924
68	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05177048
69	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.04627599
70	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.04606199
71	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.02981235
72	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.01388100
73	GATA3_26560356_Chip-Seq_TH2_Human	1.01276777
74	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01185268
75	MYC_19829295_ChIP-Seq_ESCs_Human	1.00563348
76	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.00517926
77	IRF1_19129219_ChIP-ChIP_H3396_Human	1.00379924
78	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98214735
79	CBP_20019798_ChIP-Seq_JUKART_Human	0.97561554
80	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97561554
81	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.97235802
82	EZH2_22144423_ChIP-Seq_EOC_Human	0.97065947
83	PHF8_20622853_ChIP-Seq_HELA_Human	0.96439987
84	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.96173038
85	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	0.96150788
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.95809389
87	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95536786
88	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.95458496
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.95201587
90	MYC_19079543_ChIP-ChIP_MESCs_Mouse	0.95193595
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.95044872
92	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.94921918
93	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.94912123
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.94789016
95	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.94700431
96	TCF4_22108803_ChIP-Seq_LS180_Human	0.93537925
97	RNF2_27304074_Chip-Seq_NSC_Mouse	0.92080391
98	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.91406114
99	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.91129259
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.90092813

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.29475922
2	MP0006292_abnormal_olfactory_placode	3.64196760
3	MP0000372_irregular_coat_pigmentation	3.05095188
4	MP0002102_abnormal_ear_morphology	2.84293272
5	MP0005671_abnormal_response_to	2.80155506
6	MP0003880_abnormal_central_pattern	2.67136293
7	MP0008877_abnormal_DNA_methylation	2.45400979
8	MP0004147_increased_porphyrin_level	2.44581683
9	MP0003136_yellow_coat_color	2.08480726
10	MP0005075_abnormal_melanosome_morpholog	2.07469668
11	MP0003646_muscle_fatigue	2.05311783
12	MP0002277_abnormal_respiratory_mucosa	2.00182650
13	MP0004142_abnormal_muscle_tone	1.84940342
14	MP0006276_abnormal_autonomic_nervous	1.84645367
15	MP0003122_maternal_imprinting	1.83979764
16	MP0001986_abnormal_taste_sensitivity	1.77358564
17	MP0002095_abnormal_skin_pigmentation	1.71524089
18	MP0004145_abnormal_muscle_electrophysio	1.70659574
19	MP0002234_abnormal_pharynx_morphology	1.70181803
20	MP0005551_abnormal_eye_electrophysiolog	1.68898423
21	MP0005253_abnormal_eye_physiology	1.67635356
22	MP0001764_abnormal_homeostasis	1.64897253
23	MP0003693_abnormal_embryo_hatching	1.62816317
24	MP0002132_abnormal_respiratory_system	1.60297985
25	MP0006072_abnormal_retinal_apoptosis	1.59508096
26	MP0002163_abnormal_gland_morphology	1.59040438
27	MP0008875_abnormal_xenobiotic_pharmacok	1.56914379
28	MP0002938_white_spotting	1.56799363
29	MP0002837_dystrophic_cardiac_calcinosis	1.54702470
30	MP0008872_abnormal_physiological_respon	1.53891836
31	MP0003787_abnormal_imprinting	1.50640276
32	MP0001485_abnormal_pinna_reflex	1.50581277
33	MP0000631_abnormal_neuroendocrine_gland	1.49965921
34	MP0003186_abnormal_redox_activity	1.46512194
35	MP0005084_abnormal_gallbladder_morpholo	1.46104968
36	MP0005645_abnormal_hypothalamus_physiol	1.41337616
37	MP0002876_abnormal_thyroid_physiology	1.39183375
38	MP0008995_early_reproductive_senescence	1.38924109
39	MP0005377_hearing/vestibular/ear_phenot	1.36459334
40	MP0003878_abnormal_ear_physiology	1.36459334
41	MP0001905_abnormal_dopamine_level	1.35811443
42	MP0004885_abnormal_endolymph	1.34684920
43	MP0003786_premature_aging	1.31859462
44	MP0005379_endocrine/exocrine_gland_phen	1.30001778
45	MP0008058_abnormal_DNA_repair	1.29120408
46	MP0000049_abnormal_middle_ear	1.28594988
47	MP0004134_abnormal_chest_morphology	1.28230784
48	MP0002638_abnormal_pupillary_reflex	1.28196227
49	MP0001293_anophthalmia	1.26351786
50	MP0005410_abnormal_fertilization	1.20306283
51	MP0002736_abnormal_nociception_after	1.19365718
52	MP0006036_abnormal_mitochondrial_physio	1.17858371
53	MP0003011_delayed_dark_adaptation	1.15240719
54	MP0009333_abnormal_splenocyte_physiolog	1.12822823
55	MP0002160_abnormal_reproductive_system	1.12371196
56	MP0006035_abnormal_mitochondrial_morpho	1.10998369
57	MP0003806_abnormal_nucleotide_metabolis	1.09741632
58	MP0005389_reproductive_system_phenotype	1.02930863
59	MP0001963_abnormal_hearing_physiology	1.01534986
60	MP0003718_maternal_effect	1.01496051
61	MP0003121_genomic_imprinting	1.00967057
62	MP0009697_abnormal_copulation	1.00430083
63	MP0005670_abnormal_white_adipose	0.99302515
64	MP0005646_abnormal_pituitary_gland	0.99137880
65	MP0002148_abnormal_hypersensitivity_rea	0.95881570
66	MP0005085_abnormal_gallbladder_physiolo	0.92823717
67	MP0002090_abnormal_vision	0.92140675
68	MP0009785_altered_susceptibility_to	0.91800263
69	MP0000026_abnormal_inner_ear	0.91265962
70	MP0002138_abnormal_hepatobiliary_system	0.90769253
71	MP0001119_abnormal_female_reproductive	0.89603270
72	MP0004043_abnormal_pH_regulation	0.89311707
73	MP0001661_extended_life_span	0.89100287
74	MP0001324_abnormal_eye_pigmentation	0.88875075
75	MP0002653_abnormal_ependyma_morphology	0.88062304
76	MP0000647_abnormal_sebaceous_gland	0.85250260
77	MP0005174_abnormal_tail_pigmentation	0.84448095
78	MP0005408_hypopigmentation	0.83933847
79	MP0004742_abnormal_vestibular_system	0.82640479
80	MP0008789_abnormal_olfactory_epithelium	0.82425040
81	MP0001929_abnormal_gametogenesis	0.80284339
82	MP0003195_calcinosis	0.80135198
83	MP0005195_abnormal_posterior_eye	0.76981092
84	MP0001968_abnormal_touch/_nociception	0.75798429
85	MP0003698_abnormal_male_reproductive	0.75696188
86	MP0001529_abnormal_vocalization	0.74988504
87	MP0003567_abnormal_fetal_cardiomyocyte	0.73961193
88	MP0003938_abnormal_ear_development	0.72083566
89	MP0002210_abnormal_sex_determination	0.70523620
90	MP0005391_vision/eye_phenotype	0.70257398
91	MP0002752_abnormal_somatic_nervous	0.69852444
92	MP0005332_abnormal_amino_acid	0.68194145
93	MP0003763_abnormal_thymus_physiology	0.67452060
94	MP0006082_CNS_inflammation	0.67032728
95	MP0002751_abnormal_autonomic_nervous	0.66912676
96	MP0001984_abnormal_olfaction	0.66093814
97	MP0009745_abnormal_behavioral_response	0.64926035
98	MP0000653_abnormal_sex_gland	0.64409990
99	MP0002723_abnormal_immune_serum	0.64102715
100	MP0004133_heterotaxia	0.63388024

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	4.79462792
2	Acute necrotizing encephalopathy (HP:0006965)	4.43678845
3	Mitochondrial inheritance (HP:0001427)	4.32192038
4	3-Methylglutaconic aciduria (HP:0003535)	4.17892073
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.13584253
6	Increased CSF lactate (HP:0002490)	3.96750710
7	Hepatocellular necrosis (HP:0001404)	3.96679862
8	Acute encephalopathy (HP:0006846)	3.86776236
9	Aplastic anemia (HP:0001915)	3.73090703
10	Progressive macrocephaly (HP:0004481)	3.68096472
11	Hepatic necrosis (HP:0002605)	3.61421490
12	Increased hepatocellular lipid droplets (HP:0006565)	3.42181617
13	Lipid accumulation in hepatocytes (HP:0006561)	3.24228414
14	Pancreatic fibrosis (HP:0100732)	3.15730223
15	Pancreatic cysts (HP:0001737)	3.13742710
16	Macrocytic anemia (HP:0001972)	3.07189254
17	Cerebral edema (HP:0002181)	3.03735814
18	True hermaphroditism (HP:0010459)	3.03254424
19	Renal Fanconi syndrome (HP:0001994)	3.03068443
20	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.97719153
21	Chronic hepatic failure (HP:0100626)	2.97340240
22	Increased intramyocellular lipid droplets (HP:0012240)	2.96989539
23	Abnormality of cells of the erythroid lineage (HP:0012130)	2.93324311
24	Colon cancer (HP:0003003)	2.85182820
25	Abolished electroretinogram (ERG) (HP:0000550)	2.81193112
26	Congenital stationary night blindness (HP:0007642)	2.80195187
27	Molar tooth sign on MRI (HP:0002419)	2.78782571
28	Abnormality of midbrain morphology (HP:0002418)	2.78782571
29	Optic disc pallor (HP:0000543)	2.78177874
30	Abnormal number of erythroid precursors (HP:0012131)	2.74534961
31	Increased serum lactate (HP:0002151)	2.58495414
32	Increased muscle lipid content (HP:0009058)	2.51700259
33	Abnormal rod and cone electroretinograms (HP:0008323)	2.51642172
34	Respiratory difficulties (HP:0002880)	2.50138279
35	Concave nail (HP:0001598)	2.47264540
36	Pallor (HP:0000980)	2.45771383
37	Lactic acidosis (HP:0003128)	2.41476557
38	Decreased central vision (HP:0007663)	2.41001469
39	Hyperglycinemia (HP:0002154)	2.36695372
40	Abnormality of urine glucose concentration (HP:0011016)	2.34980055
41	Glycosuria (HP:0003076)	2.34980055
42	Medial flaring of the eyebrow (HP:0010747)	2.31537836
43	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.28209627
44	IgG deficiency (HP:0004315)	2.25622072
45	Nephronophthisis (HP:0000090)	2.24869324
46	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.20628472
47	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.20628472
48	Attenuation of retinal blood vessels (HP:0007843)	2.17582627
49	Septo-optic dysplasia (HP:0100842)	2.14312614
50	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.13901937
51	Respiratory failure (HP:0002878)	2.13257038
52	Exertional dyspnea (HP:0002875)	2.11455117
53	Abnormality of DNA repair (HP:0003254)	2.11442633
54	Increased IgM level (HP:0003496)	2.11418105
55	Abnormality of methionine metabolism (HP:0010901)	2.09540394
56	Constricted visual fields (HP:0001133)	2.08950330
57	T lymphocytopenia (HP:0005403)	2.08530771
58	Lethargy (HP:0001254)	2.05901714
59	Stenosis of the external auditory canal (HP:0000402)	2.05334899
60	Optic nerve hypoplasia (HP:0000609)	2.02164065
61	Absent thumb (HP:0009777)	2.01674180
62	Leukodystrophy (HP:0002415)	1.99715628
63	Abnormality of T cell number (HP:0011839)	1.99401768
64	CNS demyelination (HP:0007305)	1.99083296
65	Methylmalonic acidemia (HP:0002912)	1.96807038
66	Sclerocornea (HP:0000647)	1.95155202
67	Nephrogenic diabetes insipidus (HP:0009806)	1.95060055
68	Type 2 muscle fiber atrophy (HP:0003554)	1.93662827
69	Abnormality of the renal collecting system (HP:0004742)	1.93429932
70	Testicular atrophy (HP:0000029)	1.92913705
71	Depressed nasal ridge (HP:0000457)	1.91992734
72	Congenital primary aphakia (HP:0007707)	1.91433310
73	Exercise intolerance (HP:0003546)	1.90925230
74	Abnormality of the labia minora (HP:0012880)	1.88705967
75	Type I transferrin isoform profile (HP:0003642)	1.87220285
76	Renal cortical cysts (HP:0000803)	1.86079153
77	Pancytopenia (HP:0001876)	1.85749288
78	Intestinal atresia (HP:0011100)	1.85525601
79	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.85462395
80	Abnormality of renal resorption (HP:0011038)	1.83101736
81	Gait imbalance (HP:0002141)	1.82989136
82	Aplasia/hypoplasia of the uterus (HP:0008684)	1.82371405
83	Methylmalonic aciduria (HP:0012120)	1.82311633
84	Male pseudohermaphroditism (HP:0000037)	1.82196137
85	Abnormality of the renal cortex (HP:0011035)	1.81567808
86	Abnormal respiratory epithelium morphology (HP:0012253)	1.80777604
87	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80777604
88	Cystic liver disease (HP:0006706)	1.79835494
89	Absent/shortened dynein arms (HP:0200106)	1.78973352
90	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.78973352
91	Absent septum pellucidum (HP:0001331)	1.78322806
92	Hypoproteinemia (HP:0003075)	1.77974866
93	Anencephaly (HP:0002323)	1.77513689
94	Partial duplication of thumb phalanx (HP:0009944)	1.77287341
95	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.77081210
96	Abnormality of alanine metabolism (HP:0010916)	1.77081210
97	Hyperalaninemia (HP:0003348)	1.77081210
98	Supernumerary spleens (HP:0009799)	1.76313967
99	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.75506737
100	Elevated erythrocyte sedimentation rate (HP:0003565)	1.73594832

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	3.95782100
2	MAP4K2	3.69093991
3	VRK2	3.45328187
4	BCKDK	3.26072763
5	ZAK	2.94694789
6	TLK1	2.91783947
7	KDR	2.65740703
8	VRK1	2.47314735
9	MAP3K12	2.39056414
10	NUAK1	2.37314300
11	CDK19	2.22507451
12	TXK	2.09579251
13	MUSK	2.05790028
14	ADRBK2	2.01650890
15	PDK2	1.96101674
16	GRK1	1.89656401
17	WNK4	1.81854621
18	WNK3	1.80489058
19	BMPR1B	1.71895299
20	FRK	1.64515453
21	TAOK3	1.56584130
22	PASK	1.51429532
23	SRPK1	1.44201195
24	TAF1	1.43571231
25	MST4	1.42522150
26	PINK1	1.41366577
27	TRIM28	1.37212569
28	DYRK2	1.23253836
29	MAP3K4	1.22687538
30	INSRR	1.19833018
31	TESK1	1.15141067
32	MKNK1	1.05876048
33	MAP2K7	1.05281262
34	RPS6KA4	1.02225183
35	BUB1	1.00141566
36	TGFBR1	0.99138318
37	PLK3	0.93797909
38	LIMK1	0.91679090
39	NME1	0.90484592
40	PRKCQ	0.88710666
41	CDK8	0.87045664
42	TIE1	0.86123786
43	GRK7	0.81895070
44	RPS6KA5	0.81719957
45	ITK	0.81075760
46	MYLK	0.74593809
47	MAPK15	0.72236694
48	OXSR1	0.71607768
49	EPHA4	0.68189511
50	DAPK1	0.68152938
51	STK39	0.64580651
52	BCR	0.64515827
53	SCYL2	0.63923150
54	NEK1	0.63094933
55	PIK3CA	0.63086995
56	PLK2	0.61507521
57	DYRK1B	0.61478514
58	PRKCH	0.60328614
59	CAMK1	0.59937972
60	GRK5	0.59363129
61	MAP3K5	0.59213799
62	DAPK3	0.57853998
63	TEC	0.56263109
64	CDC7	0.56232100
65	CSNK1G3	0.55569097
66	MAPKAPK5	0.55354594
67	SYK	0.53730812
68	PRKCG	0.51519478
69	MATK	0.50981380
70	CSNK2A2	0.50605771
71	MAP3K11	0.49725746
72	ILK	0.49447178
73	AURKB	0.49206092
74	CSNK1G2	0.49134276
75	CSNK1G1	0.47460075
76	OBSCN	0.47444965
77	PLK4	0.47039581
78	FGFR2	0.46527290
79	TNIK	0.45185470
80	MAPK13	0.44310722
81	KIT	0.43208518
82	STK16	0.42952565
83	IKBKB	0.42651362
84	LCK	0.41663670
85	CDK3	0.41326523
86	MAP4K1	0.41324320
87	PRKACA	0.41153020
88	CSNK2A1	0.40590009
89	ADRBK1	0.40188111
90	PLK1	0.39983379
91	NEK2	0.39438055
92	PIM1	0.38357363
93	CSNK1A1	0.38245310
94	PBK	0.38032760
95	WEE1	0.35276445
96	TNK2	0.35150668
97	PRKCE	0.34961122
98	ATR	0.34761873
99	EIF2AK3	0.34629403
100	ERBB3	0.34329484

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.84757515
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.25856900
3	Parkinsons disease_Homo sapiens_hsa05012	3.76639307
4	Proteasome_Homo sapiens_hsa03050	3.70592213
5	Protein export_Homo sapiens_hsa03060	2.76245340
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.57715915
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.53741394
8	Huntingtons disease_Homo sapiens_hsa05016	2.53519703
9	Alzheimers disease_Homo sapiens_hsa05010	2.44711637
10	Primary immunodeficiency_Homo sapiens_hsa05340	2.35351266
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.23109291
12	RNA polymerase_Homo sapiens_hsa03020	2.06417965
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.99433571
14	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.77690175
15	Caffeine metabolism_Homo sapiens_hsa00232	1.71710205
16	Basal transcription factors_Homo sapiens_hsa03022	1.49464341
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49161132
18	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.48141901
19	Homologous recombination_Homo sapiens_hsa03440	1.45289291
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.39821431
21	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.38579363
22	RNA degradation_Homo sapiens_hsa03018	1.37298191
23	Propanoate metabolism_Homo sapiens_hsa00640	1.36334732
24	Butanoate metabolism_Homo sapiens_hsa00650	1.30518150
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.28236171
26	Allograft rejection_Homo sapiens_hsa05330	1.24576559
27	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.24353112
28	Peroxisome_Homo sapiens_hsa04146	1.23662463
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.22948086
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22862849
31	Asthma_Homo sapiens_hsa05310	1.19627651
32	Nitrogen metabolism_Homo sapiens_hsa00910	1.18801663
33	Phototransduction_Homo sapiens_hsa04744	1.18517333
34	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.17443345
35	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.14195364
36	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.11190088
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09659566
38	Mismatch repair_Homo sapiens_hsa03430	1.07281898
39	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07233629
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.05523065
41	Antigen processing and presentation_Homo sapiens_hsa04612	1.04489565
42	Nucleotide excision repair_Homo sapiens_hsa03420	1.04224361
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00054486
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.99445744
45	Retinol metabolism_Homo sapiens_hsa00830	0.99436773
46	Type I diabetes mellitus_Homo sapiens_hsa04940	0.96890103
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.96656028
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.93895279
49	One carbon pool by folate_Homo sapiens_hsa00670	0.90939418
50	RNA transport_Homo sapiens_hsa03013	0.90649716
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89417414
52	Purine metabolism_Homo sapiens_hsa00230	0.85572000
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.82316784
54	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.81088474
55	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.80764901
56	Spliceosome_Homo sapiens_hsa03040	0.80326654
57	Taste transduction_Homo sapiens_hsa04742	0.80268138
58	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.79447383
59	Metabolic pathways_Homo sapiens_hsa01100	0.78643792
60	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77935286
61	Glutathione metabolism_Homo sapiens_hsa00480	0.74992777
62	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.71997462
63	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.71969089
64	Base excision repair_Homo sapiens_hsa03410	0.69259294
65	Olfactory transduction_Homo sapiens_hsa04740	0.62190798
66	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.62147969
67	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61207318
68	Fat digestion and absorption_Homo sapiens_hsa04975	0.60635783
69	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.59989563
70	Ether lipid metabolism_Homo sapiens_hsa00565	0.59275177
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.56098927
72	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.56073724
73	Sulfur relay system_Homo sapiens_hsa04122	0.53732008
74	Basal cell carcinoma_Homo sapiens_hsa05217	0.53432008
75	Pyruvate metabolism_Homo sapiens_hsa00620	0.53115005
76	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.52416016
77	DNA replication_Homo sapiens_hsa03030	0.51719974
78	Rheumatoid arthritis_Homo sapiens_hsa05323	0.51556073
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47492730
80	Fatty acid elongation_Homo sapiens_hsa00062	0.44494983
81	Fatty acid degradation_Homo sapiens_hsa00071	0.42589314
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.38930054
83	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36249384
84	Non-homologous end-joining_Homo sapiens_hsa03450	0.32345401
85	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32300484
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.32294007
87	Nicotine addiction_Homo sapiens_hsa05033	0.31420713
88	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30423971
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28393516
90	Folate biosynthesis_Homo sapiens_hsa00790	0.27877310
91	Sulfur metabolism_Homo sapiens_hsa00920	0.26494955
92	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.22725068
93	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.19993490
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.19808922
95	Regulation of autophagy_Homo sapiens_hsa04140	0.18971381
96	Steroid biosynthesis_Homo sapiens_hsa00100	0.17276652
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.17021122
98	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.14791536
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.13874970
100	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.13044829

RPL7AP26

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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