RPL7AP28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.83793499
2positive regulation of mitochondrial fission (GO:0090141)6.60596014
3negative regulation of gluconeogenesis (GO:0045721)5.74959063
4detection of calcium ion (GO:0005513)5.56760981
5keratinocyte development (GO:0003334)5.33246023
6presynaptic membrane organization (GO:0097090)5.30188186
7positive regulation of protein autophosphorylation (GO:0031954)5.26956671
8regulation of type B pancreatic cell apoptotic process (GO:2000674)4.86596422
9positive regulation of neurotransmitter secretion (GO:0001956)4.85444096
10positive regulation of mitotic sister chromatid separation (GO:1901970)4.67078409
11positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.67078409
12positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.67078409
13L-alpha-amino acid transmembrane transport (GO:1902475)4.60306707
14regulation of mitochondrial fission (GO:0090140)4.60305575
15positive regulation of glycolytic process (GO:0045821)4.59355732
16dendritic spine morphogenesis (GO:0060997)4.14262433
17negative regulation of keratinocyte proliferation (GO:0010839)4.07163376
18fibroblast migration (GO:0010761)4.04335138
19negative regulation of chemokine production (GO:0032682)4.00302338
20positive regulation of neurotransmitter transport (GO:0051590)3.92584305
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.91873186
22toxin transport (GO:1901998)3.88077876
23respiratory chain complex IV assembly (GO:0008535)3.79841666
24neurotransmitter-gated ion channel clustering (GO:0072578)3.77228363
25regulation of energy homeostasis (GO:2000505)3.66641137
26sphingomyelin metabolic process (GO:0006684)3.65835888
27positive regulation of action potential (GO:0045760)3.61333459
28microtubule cytoskeleton organization involved in mitosis (GO:1902850)3.58702438
29positive regulation of insulin secretion (GO:0032024)3.56011682
30cytochrome complex assembly (GO:0017004)3.52625675
31maternal behavior (GO:0042711)3.49612168
32negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.49117015
33cellular response to exogenous dsRNA (GO:0071360)3.45737103
34regulation of B cell apoptotic process (GO:0002902)3.41658697
35lactate metabolic process (GO:0006089)3.41508427
36positive regulation of peptide hormone secretion (GO:0090277)3.41044808
37inositol phosphate catabolic process (GO:0071545)3.37577234
38spindle assembly involved in mitosis (GO:0090307)3.35915780
39negative regulation of execution phase of apoptosis (GO:1900118)3.35844810
40negative regulation of organ growth (GO:0046621)3.35171513
41snRNA transcription (GO:0009301)3.33853970
42positive regulation of peptide secretion (GO:0002793)3.31064120
43protein K6-linked ubiquitination (GO:0085020)3.30897401
44regulation of metalloenzyme activity (GO:0048552)3.28900900
45cellular response to follicle-stimulating hormone stimulus (GO:0071372)3.27509243
46regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.26976599
47positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.26901233
48positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25181643
49neuron cell-cell adhesion (GO:0007158)3.20387014
50parental behavior (GO:0060746)3.19523457
51regulation of action potential (GO:0098900)3.19158496
52multicellular organismal reproductive behavior (GO:0033057)3.15379168
53postsynaptic membrane organization (GO:0001941)3.14844163
54regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.13265590
55positive regulation of gluconeogenesis (GO:0045722)3.06289437
56nucleobase catabolic process (GO:0046113)3.05061481
57positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.04353847
58mitochondrial fission (GO:0000266)3.03970219
59positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.02921134
60membrane assembly (GO:0071709)3.01247591
61negative regulation of adherens junction organization (GO:1903392)2.95309214
62negative regulation of focal adhesion assembly (GO:0051895)2.95309214
63negative regulation of cell junction assembly (GO:1901889)2.95309214
64phosphorylated carbohydrate dephosphorylation (GO:0046838)2.93937718
65inositol phosphate dephosphorylation (GO:0046855)2.93937718
66early endosome to late endosome transport (GO:0045022)2.91631823
67positive regulation of Rap GTPase activity (GO:0032854)2.91412127
68protein heterotetramerization (GO:0051290)2.89743278
69regulation of gluconeogenesis (GO:0006111)2.89700918
70negative regulation of membrane potential (GO:0045837)2.88386482
71auditory receptor cell differentiation (GO:0042491)2.86209648
72myelin maintenance (GO:0043217)2.85432677
73platelet dense granule organization (GO:0060155)2.83997343
74vesicle docking involved in exocytosis (GO:0006904)2.81371717
75regulation of protein sumoylation (GO:0033233)2.80881551
76insulin secretion (GO:0030073)2.80399438
77regulation of protein autophosphorylation (GO:0031952)2.78957537
78adenosine metabolic process (GO:0046085)2.78777009
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.78269910
80negative regulation of acute inflammatory response (GO:0002674)2.75116665
81peptide catabolic process (GO:0043171)2.75113459
82rhodopsin mediated signaling pathway (GO:0016056)2.73426214
83cell adhesion mediated by integrin (GO:0033627)2.70802189
84mature B cell differentiation (GO:0002335)2.69896624
85negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.68871968
86regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.66464373
87regulation of oxidative phosphorylation (GO:0002082)2.66350170
88glomerular basement membrane development (GO:0032836)2.65934549
89histamine secretion (GO:0001821)2.65113123
90positive regulation of hormone secretion (GO:0046887)2.64692108
91protein targeting to vacuole (GO:0006623)2.63572188
92protein targeting to lysosome (GO:0006622)2.63572188
93establishment of protein localization to vacuole (GO:0072666)2.63572188
94vesicle localization (GO:0051648)2.60525386
95regulation of B cell receptor signaling pathway (GO:0050855)2.59317526
96negative regulation of catecholamine secretion (GO:0033604)2.56216603
97neuron maturation (GO:0042551)2.56019524
98axoneme assembly (GO:0035082)2.54656882
99water-soluble vitamin biosynthetic process (GO:0042364)2.54181933
100endocrine pancreas development (GO:0031018)2.52455857

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.68948066
2RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.90644451
3GBX2_23144817_ChIP-Seq_PC3_Human2.63187657
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.42089843
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.20040286
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse11.1533138
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.98897563
8ZFP57_27257070_Chip-Seq_ESCs_Mouse1.98545086
9STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83489382
10PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83267736
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82576650
12TRIM28_21343339_ChIP-Seq_HEK293_Human1.78592708
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77628594
14CDX2_19796622_ChIP-Seq_MESCs_Mouse1.77337628
15EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.70127207
16PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67256344
17MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.61083094
18AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59291919
19HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.58726623
20AR_25329375_ChIP-Seq_VCAP_Human1.51812098
21SMAD4_21799915_ChIP-Seq_A2780_Human1.51594874
22SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50179644
23POU3F2_20337985_ChIP-ChIP_501MEL_Human1.48194052
24NR3C1_21868756_ChIP-Seq_MCF10A_Human1.47461820
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.46964972
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.45375201
27GATA2_21666600_ChIP-Seq_HMVEC_Human1.44316639
28CJUN_26792858_Chip-Seq_BT549_Human1.40910205
29AHR_22903824_ChIP-Seq_MCF-7_Human1.38166279
30SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36736625
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.36284437
32FUS_26573619_Chip-Seq_HEK293_Human1.33763782
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32253816
34NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27189116
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.25760411
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.25760411
37TP53_18474530_ChIP-ChIP_U2OS_Human1.25645510
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.24309894
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21264371
40VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21106369
41WT1_19549856_ChIP-ChIP_CCG9911_Human1.20336752
42TBL1_22424771_ChIP-Seq_293T_Human1.20187448
43FLI1_21867929_ChIP-Seq_TH2_Mouse1.20173224
44TP53_16413492_ChIP-PET_HCT116_Human1.18556215
45RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18359749
46P300_19829295_ChIP-Seq_ESCs_Human1.18308228
47EZH2_22144423_ChIP-Seq_EOC_Human1.17413781
48PRDM14_20953172_ChIP-Seq_ESCs_Human1.17123853
49IGF1R_20145208_ChIP-Seq_DFB_Human1.14821899
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14619379
51CBP_20019798_ChIP-Seq_JUKART_Human1.14619379
52IKZF1_21737484_ChIP-ChIP_HCT116_Human1.14075719
53BRD4_25478319_ChIP-Seq_HGPS_Human1.13743174
54P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12495610
55STAT3_23295773_ChIP-Seq_U87_Human1.12110092
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.11601973
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10826018
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10826018
59NFYA_21822215_ChIP-Seq_K562_Human1.10718563
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.05503177
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05158092
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04952463
63OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04258835
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03821373
65ZNF274_21170338_ChIP-Seq_K562_Hela1.03513982
66CDX2_22108803_ChIP-Seq_LS180_Human1.03101432
67ER_23166858_ChIP-Seq_MCF-7_Human0.99989995
68TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.99860196
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99003225
70JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98698188
71EP300_21415370_ChIP-Seq_HL-1_Mouse0.98603966
72VDR_24787735_ChIP-Seq_THP-1_Human0.98137056
73BCAT_22108803_ChIP-Seq_LS180_Human0.97622318
74JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97575102
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96896936
76CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95938997
77GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95613407
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94837850
79IRF1_19129219_ChIP-ChIP_H3396_Human0.94639144
80SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92737716
81SOX2_21211035_ChIP-Seq_LN229_Gbm0.91139564
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.89844304
83FOXA1_25552417_ChIP-Seq_VCAP_Human0.89651956
84NANOG_18555785_Chip-Seq_ESCs_Mouse0.88808631
85TCF4_23295773_ChIP-Seq_U87_Human0.88295977
86FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88002960
87EWS_26573619_Chip-Seq_HEK293_Human0.88000333
88WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87454862
89KDM2B_26808549_Chip-Seq_REH_Human0.87289485
90PHF8_20622853_ChIP-Seq_HELA_Human0.87216463
91SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86934878
92HNFA_21074721_ChIP-Seq_CACO-2_Human0.86444404
93NFYB_21822215_ChIP-Seq_K562_Human0.86089478
94MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84404257
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.82464576
96TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82012374
97ERG_20517297_ChIP-Seq_VCAP_Human0.81665666
98CRX_20693478_ChIP-Seq_RETINA_Mouse0.81271350
99SMAD3_21741376_ChIP-Seq_HESCs_Human0.80238845
100SOX2_20726797_ChIP-Seq_SW620_Human0.79363469

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle7.07697822
2MP0009780_abnormal_chondrocyte_physiolo3.73931112
3MP0005379_endocrine/exocrine_gland_phen3.66621075
4MP0010352_gastrointestinal_tract_polyps3.47725743
5MP0002837_dystrophic_cardiac_calcinosis3.42259585
6MP0003787_abnormal_imprinting3.28862547
7MP0000569_abnormal_digit_pigmentation3.24669642
8MP0003172_abnormal_lysosome_physiology3.03342867
9MP0002163_abnormal_gland_morphology3.01849914
10MP0005174_abnormal_tail_pigmentation2.60990642
11MP0000013_abnormal_adipose_tissue2.60130921
12MP0000015_abnormal_ear_pigmentation2.57176484
13MP0004147_increased_porphyrin_level2.51225199
14MP0002877_abnormal_melanocyte_morpholog2.42727680
15MP0005084_abnormal_gallbladder_morpholo2.40998074
16MP0002928_abnormal_bile_duct2.30021742
17MP0008877_abnormal_DNA_methylation2.27021462
18MP0003880_abnormal_central_pattern2.22985794
19MP0002638_abnormal_pupillary_reflex2.07470184
20MP0010678_abnormal_skin_adnexa2.05496883
21MP0010386_abnormal_urinary_bladder1.94124271
22MP0005075_abnormal_melanosome_morpholog1.91160130
23MP0000003_abnormal_adipose_tissue1.85548991
24MP0005646_abnormal_pituitary_gland1.77005053
25MP0006276_abnormal_autonomic_nervous1.65772616
26MP0003075_altered_response_to1.63310251
27MP0005409_darkened_coat_color1.60437627
28MP0001905_abnormal_dopamine_level1.60022870
29MP0002295_abnormal_pulmonary_circulatio1.59856238
30MP0005408_hypopigmentation1.56533926
31MP0002736_abnormal_nociception_after1.49012605
32MP0000371_diluted_coat_color1.47154575
33MP0001661_extended_life_span1.46110557
34MP0002909_abnormal_adrenal_gland1.46015702
35MP0000467_abnormal_esophagus_morphology1.38486449
36MP0002876_abnormal_thyroid_physiology1.36992273
37MP0006054_spinal_hemorrhage1.36127528
38MP0002693_abnormal_pancreas_physiology1.33466850
39MP0005083_abnormal_biliary_tract1.32269839
40MP0008438_abnormal_cutaneous_collagen1.29606007
41MP0003300_gastrointestinal_ulcer1.28237952
42MP0001984_abnormal_olfaction1.27853722
43MP0004270_analgesia1.26849406
44MP0000516_abnormal_urinary_system1.21278125
45MP0005367_renal/urinary_system_phenotyp1.21278125
46MP0001440_abnormal_grooming_behavior1.19755080
47MP0000538_abnormal_urinary_bladder1.15587734
48MP0003303_peritoneal_inflammation1.15288196
49MP0005464_abnormal_platelet_physiology1.14333487
50MP0001348_abnormal_lacrimal_gland1.12188309
51MP0002075_abnormal_coat/hair_pigmentati1.11600115
52MP0005645_abnormal_hypothalamus_physiol1.10282457
53MP0002166_altered_tumor_susceptibility1.10080185
54MP0003186_abnormal_redox_activity1.09465173
55MP0003122_maternal_imprinting1.05161334
56MP0004272_abnormal_basement_membrane1.03946588
57MP0003566_abnormal_cell_adhesion1.03148833
58MP0003315_abnormal_perineum_morphology0.99538371
59MP0002822_catalepsy0.98488303
60MP0008057_abnormal_DNA_replication0.97886256
61MP0001186_pigmentation_phenotype0.95594810
62MP0004215_abnormal_myocardial_fiber0.95232676
63MP0009278_abnormal_bone_marrow0.94245546
64MP0003252_abnormal_bile_duct0.93389935
65MP0006072_abnormal_retinal_apoptosis0.91916812
66MP0001944_abnormal_pancreas_morphology0.91899526
67MP0001756_abnormal_urination0.90829434
68MP0010368_abnormal_lymphatic_system0.89508382
69MP0002177_abnormal_outer_ear0.88606524
70MP0001501_abnormal_sleep_pattern0.87376593
71MP0005187_abnormal_penis_morphology0.86382648
72MP0002006_tumorigenesis0.86063248
73MP0004264_abnormal_extraembryonic_tissu0.86007598
74MP0005397_hematopoietic_system_phenotyp0.85971309
75MP0001545_abnormal_hematopoietic_system0.85971309
76MP0004859_abnormal_synaptic_plasticity0.83016315
77MP0002095_abnormal_skin_pigmentation0.81572449
78MP0005394_taste/olfaction_phenotype0.78772379
79MP0005499_abnormal_olfactory_system0.78772379
80MP0001765_abnormal_ion_homeostasis0.78570335
81MP0002332_abnormal_exercise_endurance0.78526670
82MP0001968_abnormal_touch/_nociception0.78391674
83MP0001542_abnormal_bone_strength0.78389170
84MP0002060_abnormal_skin_morphology0.78382199
85MP0005647_abnormal_sex_gland0.72071862
86MP0004134_abnormal_chest_morphology0.70973597
87MP0003183_abnormal_peptide_metabolism0.70513765
88MP0005197_abnormal_uvea_morphology0.67873841
89MP0005636_abnormal_mineral_homeostasis0.67367815
90MP0002896_abnormal_bone_mineralization0.66989436
91MP0005319_abnormal_enzyme/_coenzyme0.65588231
92MP0005248_abnormal_Harderian_gland0.65226043
93MP0000343_altered_response_to0.60644498
94MP0002557_abnormal_social/conspecific_i0.59069796
95MP0008872_abnormal_physiological_respon0.59067727
96MP0005386_behavior/neurological_phenoty0.58530000
97MP0004924_abnormal_behavior0.58530000
98MP0005220_abnormal_exocrine_pancreas0.58028662
99MP0008789_abnormal_olfactory_epithelium0.57871020
100MP0003091_abnormal_cell_migration0.56471686

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)7.94658862
2Hyperinsulinemic hypoglycemia (HP:0000825)6.27247298
3Symptomatic seizures (HP:0011145)6.08243377
4Hematochezia (HP:0002573)5.79202131
5Hypoglycemic coma (HP:0001325)5.68444754
6Albinism (HP:0001022)4.91178199
7Hyperglycemia (HP:0003074)4.33572665
8Ketoacidosis (HP:0001993)4.11797920
9Enlarged penis (HP:0000040)3.98757896
10Late onset (HP:0003584)3.94839789
11Hyperthyroidism (HP:0000836)3.83878956
12Cutaneous melanoma (HP:0012056)3.54632359
13Conjunctival hamartoma (HP:0100780)3.48085246
14Asymmetry of the thorax (HP:0001555)3.36792870
15Abnormality of endocrine pancreas physiology (HP:0012093)3.26010206
16Abnormality of the pancreatic islet cells (HP:0006476)3.26010206
17Impaired proprioception (HP:0010831)3.08099323
18Hypomagnesemia (HP:0002917)3.04406772
19Testicular neoplasm (HP:0010788)2.89408855
20Bone cyst (HP:0012062)2.88901042
21Hamartoma of the eye (HP:0010568)2.81560379
22Neoplasm of the adrenal cortex (HP:0100641)2.76007365
23Large for gestational age (HP:0001520)2.74290167
24Insulin-resistant diabetes mellitus (HP:0000831)2.72919840
25Generalized hypopigmentation (HP:0007513)2.64159327
26Hemiparesis (HP:0001269)2.62267855
27Follicular hyperkeratosis (HP:0007502)2.53337017
28Delayed gross motor development (HP:0002194)2.49968597
29Ocular albinism (HP:0001107)2.46948199
30Abnormality of magnesium homeostasis (HP:0004921)2.45645540
31Lymphangioma (HP:0100764)2.41781621
32Prominent metopic ridge (HP:0005487)2.40996764
33Buphthalmos (HP:0000557)2.38634729
34Hydroxyprolinuria (HP:0003080)2.37365254
35Abnormality of proline metabolism (HP:0010907)2.37365254
36Iris hypopigmentation (HP:0007730)2.33432096
37Abnormality of aromatic amino acid family metabolism (HP:0004338)2.32166479
38Hyperventilation (HP:0002883)2.31482026
39Metaphyseal dysplasia (HP:0100255)2.31241735
40Urethral obstruction (HP:0000796)2.29099303
41Abnormality of the metopic suture (HP:0005556)2.28514326
42Prolonged bleeding time (HP:0003010)2.25518133
43Medial flaring of the eyebrow (HP:0010747)2.24008222
44Ketosis (HP:0001946)2.21765889
45Tetraparesis (HP:0002273)2.21397407
46Congenital glaucoma (HP:0001087)2.20500060
47Poor suck (HP:0002033)2.18031755
48Insulin resistance (HP:0000855)2.15947196
49Genu recurvatum (HP:0002816)2.12440328
50Hypokinesia (HP:0002375)2.10748225
51Polyphagia (HP:0002591)2.08605128
52Bony spicule pigmentary retinopathy (HP:0007737)2.06652854
53Amblyopia (HP:0000646)2.04512481
54Increased serum pyruvate (HP:0003542)2.02980004
55Atonic seizures (HP:0010819)1.97426054
56Venous insufficiency (HP:0005293)1.96517511
57Poor head control (HP:0002421)1.95309602
58Nephrogenic diabetes insipidus (HP:0009806)1.94192834
59Hyperphosphatemia (HP:0002905)1.94192110
60Increased variability in muscle fiber diameter (HP:0003557)1.93984423
61Neoplasm of the adrenal gland (HP:0100631)1.92112000
62Hypoalbuminemia (HP:0003073)1.91634660
63Abnormal albumin level (HP:0012116)1.91634660
64Heterochromia iridis (HP:0001100)1.90011880
65Neonatal respiratory distress (HP:0002643)1.89562953
66Abnormality of liposaccharide metabolism (HP:0010968)1.87777810
67Abnormality of glycosphingolipid metabolism (HP:0004343)1.87777810
68Abnormality of glycolipid metabolism (HP:0010969)1.87777810
69Soft skin (HP:0000977)1.87419580
70Palpebral edema (HP:0100540)1.86954019
71Purpura (HP:0000979)1.85162032
72Hypoproteinemia (HP:0003075)1.84123042
73Muscular hypotonia of the trunk (HP:0008936)1.82782820
74Vertebral compression fractures (HP:0002953)1.81915137
75Patchy hypopigmentation of hair (HP:0011365)1.80790219
76Gingival overgrowth (HP:0000212)1.80036517
77Aortic regurgitation (HP:0001659)1.79555612
78Dyschromatopsia (HP:0007641)1.78267412
79Mucopolysacchariduria (HP:0008155)1.77877903
80Urinary glycosaminoglycan excretion (HP:0003541)1.77877903
81Abnormality of lateral ventricle (HP:0030047)1.77499854
82Petechiae (HP:0000967)1.76657694
83Bruising susceptibility (HP:0000978)1.73140999
84Protruding tongue (HP:0010808)1.72838167
85Premature rupture of membranes (HP:0001788)1.72116327
86Mitral stenosis (HP:0001718)1.72015214
87Pancreatic fibrosis (HP:0100732)1.70613578
88Angiofibromas (HP:0010615)1.70307827
89Adenoma sebaceum (HP:0009720)1.70307827
90Abnormality of skeletal muscle fiber size (HP:0012084)1.69983063
91Menstrual irregularities (HP:0000858)1.68246717
92Pancreatic islet-cell hyperplasia (HP:0004510)1.67822313
93Furrowed tongue (HP:0000221)1.67752396
94Mesangial abnormality (HP:0001966)1.67495784
95Hypopigmentation of the fundus (HP:0007894)1.65813386
96Abnormality of polysaccharide metabolism (HP:0011012)1.65734170
97Abnormality of glycosaminoglycan metabolism (HP:0004371)1.65734170
98Abnormality of mucopolysaccharide metabolism (HP:0011020)1.65734170
99Hypoplasia of the fovea (HP:0007750)1.64980862
100Aplasia/Hypoplasia of the fovea (HP:0008060)1.64980862

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.12590809
2MST46.35152247
3TNIK4.30307775
4FGFR23.88112218
5NUAK13.02163941
6NTRK32.79344563
7NLK2.60319708
8ACVR1B2.49129910
9DMPK2.30072464
10CASK2.10677450
11STK31.92719233
12ROCK21.81570758
13BMPR1B1.50908798
14FGFR31.50379224
15MAP3K141.41722573
16PHKG11.41164176
17PHKG21.41164176
18MYLK1.36338282
19ILK1.29461129
20PNCK1.26267903
21ROCK11.22043811
22STK101.21712457
23NEK91.18544876
24DAPK21.17467377
25ADRBK21.16851436
26PRKCE1.11572583
27STK41.07357944
28EPHB21.07027249
29AKT21.01398691
30PLK20.99727859
31FER0.93831621
32PRKG20.93411457
33STK160.92297094
34SGK20.86775906
35INSRR0.83989768
36RAF10.83473908
37MAP3K100.82172596
38LRRK20.81220988
39CAMKK20.80706957
40ICK0.79864693
41MAPK110.79578358
42ADRBK10.79073474
43TGFBR10.76904033
44YES10.74766774
45BCKDK0.74607314
46SGK4940.69120344
47SGK2230.69120344
48MAP4K20.66698610
49CDK30.63893224
50HIPK20.62228707
51GSK3A0.60427386
52DDR20.59316470
53GRK10.55341051
54TRPM70.55150348
55PRKCI0.54037806
56MAP3K40.53958994
57PDGFRA0.53794347
58STK110.53532211
59PTK20.51425753
60KIT0.51364584
61PRKCQ0.49006682
62PRKG10.47629256
63PTK2B0.46473003
64MAP3K20.45811342
65TIE10.45312431
66CDK50.44389830
67IKBKB0.44293680
68SGK30.41962666
69RPS6KA40.41714885
70PAK20.41028706
71MAPK70.39062170
72STK38L0.38585282
73RPS6KA20.37335683
74MAP3K80.36356071
75TEC0.35075721
76PAK30.34920332
77PINK10.34157895
78LYN0.33917471
79CAMK2A0.33890778
80MAP2K60.33819889
81TBK10.32470261
82MAP2K70.31987559
83DAPK30.31000041
84CAMK1G0.27821166
85PRKACA0.27173456
86PLK30.24854810
87RIPK40.23526867
88CSNK1G10.20940262
89PAK10.19601117
90CAMK10.18982862
91AKT30.18555269
92DAPK10.17012207
93CDK60.15290568
94PIK3CG0.14145112
95RPS6KL10.13101422
96RPS6KC10.13101422
97PRKACB0.12822640
98JAK10.12456932
99BMPR20.12255554
100PRKACG0.11813624

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.73180781
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.53324329
3Vitamin B6 metabolism_Homo sapiens_hsa007504.50288432
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.75375521
5Insulin secretion_Homo sapiens_hsa049113.17556845
6Folate biosynthesis_Homo sapiens_hsa007902.37009742
7Butanoate metabolism_Homo sapiens_hsa006502.30092527
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17314347
9Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.15972371
10Cocaine addiction_Homo sapiens_hsa050302.12706407
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.05429838
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83953320
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.82912891
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.65268181
15Type II diabetes mellitus_Homo sapiens_hsa049301.58710938
16Fatty acid elongation_Homo sapiens_hsa000621.51937930
17Dorso-ventral axis formation_Homo sapiens_hsa043201.44781160
18cGMP-PKG signaling pathway_Homo sapiens_hsa040221.41795430
19Renin secretion_Homo sapiens_hsa049241.41579236
20Other glycan degradation_Homo sapiens_hsa005111.37005351
21Circadian rhythm_Homo sapiens_hsa047101.30413737
22Type I diabetes mellitus_Homo sapiens_hsa049401.18431149
23Vascular smooth muscle contraction_Homo sapiens_hsa042701.18047062
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16737750
25Amphetamine addiction_Homo sapiens_hsa050311.16642886
26Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15988552
27Tryptophan metabolism_Homo sapiens_hsa003801.10917595
28Sphingolipid metabolism_Homo sapiens_hsa006001.07332872
29Protein export_Homo sapiens_hsa030601.04213972
30Glycosaminoglycan degradation_Homo sapiens_hsa005310.99517009
31Collecting duct acid secretion_Homo sapiens_hsa049660.99140296
32Arginine biosynthesis_Homo sapiens_hsa002200.99032781
33Focal adhesion_Homo sapiens_hsa045100.97209103
34Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96348832
35Pancreatic secretion_Homo sapiens_hsa049720.93845084
36Circadian entrainment_Homo sapiens_hsa047130.91663467
37ECM-receptor interaction_Homo sapiens_hsa045120.91527332
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.91190930
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90238838
40Platelet activation_Homo sapiens_hsa046110.90220965
41Fatty acid degradation_Homo sapiens_hsa000710.87293539
42Mineral absorption_Homo sapiens_hsa049780.84519222
43Glucagon signaling pathway_Homo sapiens_hsa049220.82171602
44Dopaminergic synapse_Homo sapiens_hsa047280.81906275
45RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80346452
46ABC transporters_Homo sapiens_hsa020100.79011657
47Thyroid hormone synthesis_Homo sapiens_hsa049180.74595170
48Prostate cancer_Homo sapiens_hsa052150.71056393
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.67781938
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.65250566
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65145177
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63941554
53Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61989779
54Long-term depression_Homo sapiens_hsa047300.60261866
55Lysosome_Homo sapiens_hsa041420.59559732
56Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57819840
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.57804674
58Amoebiasis_Homo sapiens_hsa051460.56608476
59Glutamatergic synapse_Homo sapiens_hsa047240.56325878
60Histidine metabolism_Homo sapiens_hsa003400.54858598
61Salivary secretion_Homo sapiens_hsa049700.54674052
62cAMP signaling pathway_Homo sapiens_hsa040240.54664638
63Protein digestion and absorption_Homo sapiens_hsa049740.52887092
64Oxytocin signaling pathway_Homo sapiens_hsa049210.52309456
65Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51924192
66Insulin resistance_Homo sapiens_hsa049310.51637560
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51192757
68Regulation of autophagy_Homo sapiens_hsa041400.51133580
69Caffeine metabolism_Homo sapiens_hsa002320.51028216
70Vibrio cholerae infection_Homo sapiens_hsa051100.48053176
71Small cell lung cancer_Homo sapiens_hsa052220.47867779
72Rheumatoid arthritis_Homo sapiens_hsa053230.47588280
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44532175
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.43023773
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41932306
76Pertussis_Homo sapiens_hsa051330.41517589
77Glycerolipid metabolism_Homo sapiens_hsa005610.40166431
78Sulfur metabolism_Homo sapiens_hsa009200.38645565
79Cholinergic synapse_Homo sapiens_hsa047250.36645297
80mTOR signaling pathway_Homo sapiens_hsa041500.35103678
81Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33873802
82Pentose phosphate pathway_Homo sapiens_hsa000300.33377205
83Gastric acid secretion_Homo sapiens_hsa049710.31024173
84Synaptic vesicle cycle_Homo sapiens_hsa047210.30608437
85Arginine and proline metabolism_Homo sapiens_hsa003300.30074959
86Serotonergic synapse_Homo sapiens_hsa047260.29886025
87GABAergic synapse_Homo sapiens_hsa047270.29193830
88AMPK signaling pathway_Homo sapiens_hsa041520.28159135
89Shigellosis_Homo sapiens_hsa051310.27669678
90Carbohydrate digestion and absorption_Homo sapiens_hsa049730.26579829
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25312789
92Central carbon metabolism in cancer_Homo sapiens_hsa052300.24783046
93Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.24329533
94Phagosome_Homo sapiens_hsa041450.22808254
95Tight junction_Homo sapiens_hsa045300.21824823
96Endocytosis_Homo sapiens_hsa041440.21689487
97Bile secretion_Homo sapiens_hsa049760.21156070
98Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.20176176
99Morphine addiction_Homo sapiens_hsa050320.20029322
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19867372

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