RPL7AP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1translational termination (GO:0006415)9.75146651
2ribosomal small subunit assembly (GO:0000028)8.72483541
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)8.23057944
4translational elongation (GO:0006414)8.12038888
5cotranslational protein targeting to membrane (GO:0006613)8.09533245
6protein targeting to ER (GO:0045047)8.07093251
7establishment of protein localization to endoplasmic reticulum (GO:0072599)7.71527914
8protein localization to endoplasmic reticulum (GO:0070972)7.58084064
9viral life cycle (GO:0019058)7.43454883
10cellular protein complex disassembly (GO:0043624)7.43266481
11maturation of SSU-rRNA (GO:0030490)7.40459810
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)7.17115169
13protein complex disassembly (GO:0043241)6.29167551
14translational initiation (GO:0006413)6.18521331
15macromolecular complex disassembly (GO:0032984)5.87786169
16ribosomal large subunit biogenesis (GO:0042273)5.86484650
17ribonucleoprotein complex biogenesis (GO:0022613)5.55306363
18protein targeting to membrane (GO:0006612)5.47970987
19ATP synthesis coupled proton transport (GO:0015986)5.10119758
20energy coupled proton transport, down electrochemical gradient (GO:0015985)5.10119758
21nuclear-transcribed mRNA catabolic process (GO:0000956)5.05398471
22cellular component biogenesis (GO:0044085)4.87869945
23mRNA catabolic process (GO:0006402)4.76889099
24substrate-independent telencephalic tangential migration (GO:0021826)4.74971415
25substrate-independent telencephalic tangential interneuron migration (GO:0021843)4.74971415
26translation (GO:0006412)4.73319631
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.70630781
28chaperone-mediated protein transport (GO:0072321)4.42051106
29behavioral response to nicotine (GO:0035095)4.28267082
30RNA catabolic process (GO:0006401)4.28147075
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.27124547
32establishment of protein localization to mitochondrial membrane (GO:0090151)4.02646405
33protein complex biogenesis (GO:0070271)4.01148883
34cardiovascular system development (GO:0072358)3.94966705
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.75366041
36mitochondrial respiratory chain complex I assembly (GO:0032981)3.75366041
37NADH dehydrogenase complex assembly (GO:0010257)3.75366041
38valine metabolic process (GO:0006573)3.75339107
39protein neddylation (GO:0045116)3.72965502
40respiratory electron transport chain (GO:0022904)3.72103350
41regulation of cellular respiration (GO:0043457)3.70702417
42establishment of protein localization to membrane (GO:0090150)3.70326391
43respiratory chain complex IV assembly (GO:0008535)3.70227915
44electron transport chain (GO:0022900)3.67102288
45cytochrome complex assembly (GO:0017004)3.65948337
46mitochondrion transport along microtubule (GO:0047497)3.63664384
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.63664384
48ribosome biogenesis (GO:0042254)3.61776992
49pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.54618990
50protein targeting (GO:0006605)3.52070699
51mitochondrial respiratory chain complex assembly (GO:0033108)3.50409185
52negative regulation of cardiac muscle hypertrophy (GO:0010614)3.47351706
53tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39313652
54RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39313652
55cell proliferation in forebrain (GO:0021846)3.36868535
56establishment of mitochondrion localization (GO:0051654)3.32965938
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30676943
58establishment of protein localization to organelle (GO:0072594)3.29385473
59nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.28468712
60GTP biosynthetic process (GO:0006183)3.25133280
61purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.24788828
62ATP biosynthetic process (GO:0006754)3.24680053
63ubiquinone biosynthetic process (GO:0006744)3.23904147
64sequestering of actin monomers (GO:0042989)3.21518309
65purine nucleoside triphosphate biosynthetic process (GO:0009145)3.16898925
66negative regulation of muscle hypertrophy (GO:0014741)3.13321566
67maturation of 5.8S rRNA (GO:0000460)3.11237159
68ovulation cycle (GO:0042698)3.09649302
69rRNA processing (GO:0006364)3.07188199
70positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.06871959
71pyrimidine nucleotide catabolic process (GO:0006244)3.05808348
72rRNA metabolic process (GO:0016072)3.03161760
73protein localization to membrane (GO:0072657)3.02077435
74DNA deamination (GO:0045006)2.94221479
75ubiquinone metabolic process (GO:0006743)2.92204214
76somite development (GO:0061053)2.82174278
77positive regulation of potassium ion transmembrane transport (GO:1901381)2.81106322
78ribonucleoside triphosphate biosynthetic process (GO:0009201)2.80409078
79N-terminal protein amino acid acetylation (GO:0006474)2.78873838
80UTP biosynthetic process (GO:0006228)2.78234791
81nonmotile primary cilium assembly (GO:0035058)2.77369999
82regulation of oxidative stress-induced neuron death (GO:1903203)2.75587755
83water-soluble vitamin biosynthetic process (GO:0042364)2.74381067
84signal peptide processing (GO:0006465)2.69284903
85positive regulation of respiratory burst (GO:0060267)2.68987208
86retinal ganglion cell axon guidance (GO:0031290)2.66384721
87negative regulation of appetite (GO:0032099)2.65084414
88negative regulation of response to food (GO:0032096)2.65084414
89negative regulation of glycogen biosynthetic process (GO:0045719)2.63695813
90quinone biosynthetic process (GO:1901663)2.60010846
91cellular response to interferon-beta (GO:0035458)2.58990655
92establishment of protein localization to mitochondrion (GO:0072655)2.56837792
93positive regulation of T cell apoptotic process (GO:0070234)2.55819826
94UTP metabolic process (GO:0046051)2.47354763
95seminiferous tubule development (GO:0072520)2.46392678
96resolution of meiotic recombination intermediates (GO:0000712)2.46340761
97negative regulation of potassium ion transport (GO:0043267)2.45851102
98hydrogen ion transmembrane transport (GO:1902600)2.43590848
99ribosomal small subunit biogenesis (GO:0042274)10.8927822
100viral transcription (GO:0019083)10.2112201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.58349944
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.77181182
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.67649620
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65661747
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.42989682
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.02106985
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82898672
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.74462807
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.70689288
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47861617
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.38805082
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32864870
13VDR_22108803_ChIP-Seq_LS180_Human2.18748456
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16078255
15ZNF274_21170338_ChIP-Seq_K562_Hela2.06993701
16JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98032152
17MYC_19079543_ChIP-ChIP_MESCs_Mouse1.89061717
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.88930004
19MYC_18358816_ChIP-ChIP_MESCs_Mouse1.88172814
20XRN2_22483619_ChIP-Seq_HELA_Human1.87937465
21CBX2_27304074_Chip-Seq_ESCs_Mouse1.85810957
22KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.83576075
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.82324659
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81761952
25BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74345420
26POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.72610613
27EZH2_27294783_Chip-Seq_ESCs_Mouse1.68050787
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.65847565
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62292995
30TTF2_22483619_ChIP-Seq_HELA_Human1.60737565
31SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58825182
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55264228
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.54006465
34CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52869681
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.52165653
36SOX2_18555785_ChIP-Seq_MESCs_Mouse1.49978811
37EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47911871
38CTCF_18555785_ChIP-Seq_MESCs_Mouse1.47756131
39CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.46383484
40GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.44332259
41JARID2_20075857_ChIP-Seq_MESCs_Mouse1.43593965
42CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.42079142
43TP53_20018659_ChIP-ChIP_R1E_Mouse1.39443949
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.36630605
45SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35863678
46EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.34712361
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32722709
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31731331
49VDR_23849224_ChIP-Seq_CD4+_Human1.30210041
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.30098287
51REST_21632747_ChIP-Seq_MESCs_Mouse1.27675566
52GABP_19822575_ChIP-Seq_HepG2_Human1.27317550
53NANOG_20526341_ChIP-Seq_ESCs_Human1.26602777
54IRF1_19129219_ChIP-ChIP_H3396_Human1.24912696
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24499791
56PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23988179
57RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22205844
58SA1_27219007_Chip-Seq_Bcells_Human1.20040528
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.18215764
60EZH2_18974828_ChIP-Seq_MESCs_Mouse1.18215764
61MYC_18940864_ChIP-ChIP_HL60_Human1.16976786
62SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16329615
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13247933
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.12922051
65BCL6_27268052_Chip-Seq_Bcells_Human1.12026341
66SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.10599488
67MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.10487876
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09331338
69GATA3_21878914_ChIP-Seq_MCF-7_Human1.09007681
70NCOR_22424771_ChIP-Seq_293T_Human1.08509776
71CTCF_20526341_ChIP-Seq_ESCs_Human1.07475566
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.07358519
73TP53_22573176_ChIP-Seq_HFKS_Human1.05806834
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05139245
75ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03060748
76FOXP3_21729870_ChIP-Seq_TREG_Human1.02545023
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.02039323
78ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01000913
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00775082
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00667246
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00348449
82RNF2_27304074_Chip-Seq_ESCs_Mouse1.00151582
83TDRD3_21172665_ChIP-Seq_MCF-7_Human0.98388264
84TAF2_19829295_ChIP-Seq_ESCs_Human0.97949378
85KDM5A_27292631_Chip-Seq_BREAST_Human0.95757168
86REST_18959480_ChIP-ChIP_MESCs_Mouse0.95247259
87RNF2_27304074_Chip-Seq_NSC_Mouse0.94753004
88ERG_21242973_ChIP-ChIP_JURKAT_Human0.94410433
89CTBP1_25329375_ChIP-Seq_LNCAP_Human0.93024603
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.92895964
91CTCF_27219007_Chip-Seq_Bcells_Human0.92830361
92ERA_21632823_ChIP-Seq_H3396_Human0.92802797
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92136837
94RING1B_27294783_Chip-Seq_ESCs_Mouse0.91430293
95SOX2_21211035_ChIP-Seq_LN229_Human0.90057738
96FOXH1_21741376_ChIP-Seq_ESCs_Human0.88412724
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88251718
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.86181752
99FUS_26573619_Chip-Seq_HEK293_Human0.85794738
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84947375

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation8.69702171
2MP0006292_abnormal_olfactory_placode4.07909221
3MP0002653_abnormal_ependyma_morphology3.28854971
4MP0002837_dystrophic_cardiac_calcinosis3.04072827
5MP0003123_paternal_imprinting3.02995201
6MP0003787_abnormal_imprinting2.88185604
7MP0002163_abnormal_gland_morphology2.61499070
8MP0008877_abnormal_DNA_methylation2.43147387
9MP0001986_abnormal_taste_sensitivity2.30531700
10MP0003646_muscle_fatigue2.29687372
11MP0008789_abnormal_olfactory_epithelium2.26193585
12MP0004145_abnormal_muscle_electrophysio2.25051687
13MP0005646_abnormal_pituitary_gland2.12832038
14MP0003122_maternal_imprinting2.08367259
15MP0003315_abnormal_perineum_morphology1.93309791
16MP0006054_spinal_hemorrhage1.89215743
17MP0005499_abnormal_olfactory_system1.86844721
18MP0005394_taste/olfaction_phenotype1.86844721
19MP0001188_hyperpigmentation1.72009180
20MP0003121_genomic_imprinting1.67635014
21MP0002638_abnormal_pupillary_reflex1.65183501
22MP0002160_abnormal_reproductive_system1.64721926
23MP0003186_abnormal_redox_activity1.57256958
24MP0005423_abnormal_somatic_nervous1.56495565
25MP0005379_endocrine/exocrine_gland_phen1.52429597
26MP0001529_abnormal_vocalization1.49605128
27MP0005389_reproductive_system_phenotype1.45797003
28MP0003011_delayed_dark_adaptation1.43122823
29MP0004142_abnormal_muscle_tone1.39325184
30MP0004084_abnormal_cardiac_muscle1.37807395
31MP0004130_abnormal_muscle_cell1.33214159
32MP0001919_abnormal_reproductive_system1.32675550
33MP0001348_abnormal_lacrimal_gland1.31836063
34MP0000049_abnormal_middle_ear1.31041764
35MP0006276_abnormal_autonomic_nervous1.30854516
36MP0002272_abnormal_nervous_system1.27309187
37MP0008875_abnormal_xenobiotic_pharmacok1.25490403
38MP0005187_abnormal_penis_morphology1.22369539
39MP0001293_anophthalmia1.18397178
40MP0003136_yellow_coat_color1.14815641
41MP0003693_abnormal_embryo_hatching1.14809005
42MP0001968_abnormal_touch/_nociception1.12593021
43MP0005551_abnormal_eye_electrophysiolog1.12314296
44MP0006072_abnormal_retinal_apoptosis1.10212160
45MP0008872_abnormal_physiological_respon1.08719220
46MP0003880_abnormal_central_pattern1.08682557
47MP0002938_white_spotting1.06640756
48MP0002234_abnormal_pharynx_morphology1.04328993
49MP0000631_abnormal_neuroendocrine_gland1.03009438
50MP0002736_abnormal_nociception_after1.02199744
51MP0009250_abnormal_appendicular_skeleto1.00560992
52MP0009046_muscle_twitch0.98045928
53MP0000613_abnormal_salivary_gland0.97112719
54MP0005377_hearing/vestibular/ear_phenot0.96087355
55MP0003878_abnormal_ear_physiology0.96087355
56MP0000678_abnormal_parathyroid_gland0.95881819
57MP0009745_abnormal_behavioral_response0.94823628
58MP0003195_calcinosis0.93946077
59MP0005623_abnormal_meninges_morphology0.93030410
60MP0001286_abnormal_eye_development0.92042857
61MP0002557_abnormal_social/conspecific_i0.90355607
62MP0000955_abnormal_spinal_cord0.89901381
63MP0002095_abnormal_skin_pigmentation0.88470851
64MP0000778_abnormal_nervous_system0.87443581
65MP0003942_abnormal_urinary_system0.84519038
66MP0002184_abnormal_innervation0.84306081
67MP0002822_catalepsy0.83538974
68MP0008775_abnormal_heart_ventricle0.81476318
69MP0001663_abnormal_digestive_system0.80798324
70MP0005195_abnormal_posterior_eye0.80545182
71MP0009053_abnormal_anal_canal0.79735827
72MP0002752_abnormal_somatic_nervous0.78787657
73MP0005084_abnormal_gallbladder_morpholo0.78287090
74MP0001905_abnormal_dopamine_level0.77890392
75MP0002249_abnormal_larynx_morphology0.77750180
76MP0004742_abnormal_vestibular_system0.77298062
77MP0001970_abnormal_pain_threshold0.76951933
78MP0001440_abnormal_grooming_behavior0.76167824
79MP0004858_abnormal_nervous_system0.75414871
80MP0004885_abnormal_endolymph0.70982944
81MP0002233_abnormal_nose_morphology0.70118199
82MP0003119_abnormal_digestive_system0.69601643
83MP0002572_abnormal_emotion/affect_behav0.69175868
84MP0005220_abnormal_exocrine_pancreas0.68972760
85MP0001485_abnormal_pinna_reflex0.68304861
86MP0002733_abnormal_thermal_nociception0.68269997
87MP0002277_abnormal_respiratory_mucosa0.66653665
88MP0002697_abnormal_eye_size0.66390151
89MP0000372_irregular_coat_pigmentation0.65638046
90MP0001984_abnormal_olfaction0.65441152
91MP0002210_abnormal_sex_determination0.64614363
92MP0002102_abnormal_ear_morphology0.62068178
93MP0002876_abnormal_thyroid_physiology0.61986904
94MP0003279_aneurysm0.61590123
95MP0004133_heterotaxia0.60149952
96MP0002063_abnormal_learning/memory/cond0.59893337
97MP0001486_abnormal_startle_reflex0.59431477
98MP0000026_abnormal_inner_ear0.59217048
99MP0003938_abnormal_ear_development0.59033805
100MP0001873_stomach_inflammation0.57830663

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)6.63488330
2Reticulocytopenia (HP:0001896)5.85194981
3Abnormality of cells of the erythroid lineage (HP:0012130)5.60607688
4Acute necrotizing encephalopathy (HP:0006965)5.09707611
5Abnormal number of erythroid precursors (HP:0012131)4.64218611
6Macrocytic anemia (HP:0001972)4.62691876
7Abnormal rod and cone electroretinograms (HP:0008323)4.56813202
8Abnormal mitochondria in muscle tissue (HP:0008316)4.53168218
9Chronic hepatic failure (HP:0100626)4.49384581
10Acute encephalopathy (HP:0006846)4.24559470
11Mitochondrial inheritance (HP:0001427)4.24139725
12Progressive macrocephaly (HP:0004481)4.06732030
13Pendular nystagmus (HP:0012043)3.81017196
14Pallor (HP:0000980)3.69676473
15Decreased central vision (HP:0007663)3.63902214
16Increased CSF lactate (HP:0002490)3.55581836
17Hepatocellular necrosis (HP:0001404)3.37308937
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.24627003
19Absent/shortened dynein arms (HP:0200106)3.24627003
20Increased hepatocellular lipid droplets (HP:0006565)3.19642463
21Septo-optic dysplasia (HP:0100842)3.13496109
22Cerebral edema (HP:0002181)3.12003705
23Optic disc pallor (HP:0000543)3.03722805
24Molar tooth sign on MRI (HP:0002419)2.96694979
25Abnormality of midbrain morphology (HP:0002418)2.96694979
26Pancreatic fibrosis (HP:0100732)2.93989718
27Lipid accumulation in hepatocytes (HP:0006561)2.93541148
28Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87068033
29True hermaphroditism (HP:0010459)2.83952601
30Renal Fanconi syndrome (HP:0001994)2.82404724
31Anencephaly (HP:0002323)2.74284009
32Hepatic necrosis (HP:0002605)2.73788458
33Agitation (HP:0000713)2.71980244
34Increased intramyocellular lipid droplets (HP:0012240)2.54156511
35Adrenal hypoplasia (HP:0000835)2.49292226
36Congenital stationary night blindness (HP:0007642)2.48966493
37Keratoconus (HP:0000563)2.42965169
38Increased corneal curvature (HP:0100692)2.42965169
39Elevated erythrocyte sedimentation rate (HP:0003565)2.40260133
403-Methylglutaconic aciduria (HP:0003535)2.39061778
41Pancreatic cysts (HP:0001737)2.38013549
42Increased serum lactate (HP:0002151)2.36709954
43Abnormal respiratory motile cilium morphology (HP:0005938)2.35055782
44Abnormal respiratory epithelium morphology (HP:0012253)2.35055782
45Stenosis of the external auditory canal (HP:0000402)2.32874153
46Cystic liver disease (HP:0006706)2.28863710
47Dyskinesia (HP:0100660)2.25460948
48Leukodystrophy (HP:0002415)2.24843063
49Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24329659
50Abnormality of alanine metabolism (HP:0010916)2.24329659
51Hyperalaninemia (HP:0003348)2.24329659
52Abnormality of renal resorption (HP:0011038)2.23338929
53Sclerocornea (HP:0000647)2.21794047
54Depressed nasal ridge (HP:0000457)2.21076679
55Medial flaring of the eyebrow (HP:0010747)2.20696346
56Abnormal respiratory motile cilium physiology (HP:0012261)2.20100040
57Abnormal ciliary motility (HP:0012262)2.18347816
58Respiratory failure (HP:0002878)2.16127392
59Cerebral hypomyelination (HP:0006808)2.15509052
6011 pairs of ribs (HP:0000878)2.14090580
61Type II lissencephaly (HP:0007260)2.13720248
62Increased muscle lipid content (HP:0009058)2.10671889
63Attenuation of retinal blood vessels (HP:0007843)2.10113478
64Disinhibition (HP:0000734)2.07442351
65Hypogonadotrophic hypogonadism (HP:0000044)2.07296383
66Hyperglycinemia (HP:0002154)2.06978612
67Absent thumb (HP:0009777)2.04914223
68Myokymia (HP:0002411)2.00936849
69Asplenia (HP:0001746)1.99709809
70Exertional dyspnea (HP:0002875)1.98293741
71Abnormality of magnesium homeostasis (HP:0004921)1.97022028
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.96287024
73Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96082512
74Restlessness (HP:0000711)1.96014981
75Lactic acidosis (HP:0003128)1.95188731
76Aplasia/Hypoplasia of the spleen (HP:0010451)1.93970357
77Exercise intolerance (HP:0003546)1.93452577
78Hyperphosphaturia (HP:0003109)1.92827685
79Abnormal hemoglobin (HP:0011902)1.92556960
80Maternal diabetes (HP:0009800)1.90828091
81Colon cancer (HP:0003003)1.89324523
82Abolished electroretinogram (ERG) (HP:0000550)1.88975856
83Growth hormone deficiency (HP:0000824)1.85548266
84Hypoplasia of the radius (HP:0002984)1.83387248
85Testicular atrophy (HP:0000029)1.81333647
86Postaxial foot polydactyly (HP:0001830)1.80766574
87Anosmia (HP:0000458)1.78022156
88Abnormality of the labia minora (HP:0012880)1.74652027
89Lissencephaly (HP:0001339)1.74282415
90Optic nerve hypoplasia (HP:0000609)1.74223380
91Lethargy (HP:0001254)1.73796010
92Partial duplication of thumb phalanx (HP:0009944)1.73766517
93Hypoplasia of the ulna (HP:0003022)1.71963148
94Irregular epiphyses (HP:0010582)1.69743312
95Hyperthyroidism (HP:0000836)1.69184236
96Premature ovarian failure (HP:0008209)1.68992206
97Respiratory difficulties (HP:0002880)1.68350032
98Anophthalmia (HP:0000528)1.67750305
99Nephronophthisis (HP:0000090)1.67437303
100Short femoral neck (HP:0100864)1.66922205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK6.22116490
2NME23.84559662
3LRRK23.13531811
4CAMKK13.03147663
5STK162.54919775
6DYRK22.27137405
7MAP3K132.20326680
8MAP4K12.03828202
9WNK42.02308338
10TXK2.01672440
11MAP3K111.96785843
12TYRO31.90224458
13WNK31.89976350
14PIK3CA1.88258615
15BCKDK1.87353599
16ADRBK21.82983162
17RIPK41.78228296
18EPHB21.78076299
19GRK11.65754457
20BMPR1B1.61093055
21TIE11.58351141
22CAMKK21.45949756
23ZAK1.40401127
24CDC71.38468163
25CASK1.36721508
26BRAF1.28865188
27PLK41.18330788
28NTRK21.15240613
29AKT31.14521512
30PINK11.09330610
31MAP4K21.08636632
32PRKCG1.07620405
33EPHA41.06048464
34PRKCQ0.97810085
35NEK10.94859551
36PDK20.93177906
37SGK4940.92271684
38SGK2230.92271684
39INSRR0.91669287
40PTK60.91511320
41NTRK30.87680943
42TLK10.85602005
43NEK20.85582721
44STK110.85434671
45CAMK10.81073250
46TEC0.81019185
47AURKA0.80018160
48TRIM280.78657269
49SIK20.76160326
50EIF2AK10.75839104
51ADRBK10.74459443
52KDR0.73876687
53STK390.72953033
54PRKCZ0.72558988
55PIM20.70854535
56IKBKB0.70356311
57PRKACA0.70038850
58BTK0.68937012
59MARK30.67687774
60ITK0.66996486
61MAP3K40.65725969
62CSNK2A20.65480667
63OBSCN0.64840126
64GRK70.64702672
65ABL20.63009466
66BRSK10.62502987
67CAMK1D0.61463536
68MAPK130.60408942
69PLK10.60213887
70TNIK0.58542102
71FRK0.57397906
72MAPK150.57139061
73MINK10.56526754
74PHKG20.55520277
75PHKG10.55520277
76RPS6KA60.53239334
77KIT0.51366954
78SGK10.50445847
79RPS6KA50.50293041
80SYK0.48834619
81PRKCI0.47995175
82TGFBR10.46879053
83PAK10.46080656
84LCK0.46040649
85MKNK20.45844408
86PRKCA0.43890171
87LIMK10.43176512
88PRKCD0.42954322
89CSNK2A10.42598417
90MUSK0.41650541
91AURKB0.41241829
92PIM10.40688881
93PRKACG0.38769541
94CAMK1G0.37400601
95CSNK1E0.37011643
96STK40.33778231
97IKBKE0.32501433
98DYRK30.32472929
99RPS6KL10.32082965
100RPS6KC10.32082965

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030108.73505012
2Oxidative phosphorylation_Homo sapiens_hsa001904.53598880
3Parkinsons disease_Homo sapiens_hsa050123.89716740
4Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.83880108
5Huntingtons disease_Homo sapiens_hsa050162.74110615
6Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.59549935
7Alzheimers disease_Homo sapiens_hsa050102.56350427
8Cardiac muscle contraction_Homo sapiens_hsa042602.42920886
9RNA polymerase_Homo sapiens_hsa030202.12790861
10RNA degradation_Homo sapiens_hsa030181.80507865
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65728003
12Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.65402239
13Linoleic acid metabolism_Homo sapiens_hsa005911.55627514
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.50277799
15Proteasome_Homo sapiens_hsa030501.42014728
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.40764434
17Caffeine metabolism_Homo sapiens_hsa002321.23811308
18Protein export_Homo sapiens_hsa030601.23547864
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21842785
20Pyrimidine metabolism_Homo sapiens_hsa002401.18395317
21Phototransduction_Homo sapiens_hsa047441.16151151
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12667731
23Sulfur relay system_Homo sapiens_hsa041221.11071372
24Nitrogen metabolism_Homo sapiens_hsa009101.10958695
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.09219606
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08723588
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96969719
28Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.95224319
29Primary immunodeficiency_Homo sapiens_hsa053400.94572504
30One carbon pool by folate_Homo sapiens_hsa006700.92474941
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91442462
32Olfactory transduction_Homo sapiens_hsa047400.85309760
33Tyrosine metabolism_Homo sapiens_hsa003500.83833234
34Nicotine addiction_Homo sapiens_hsa050330.83592176
35Morphine addiction_Homo sapiens_hsa050320.80390570
36Purine metabolism_Homo sapiens_hsa002300.78356189
37Tryptophan metabolism_Homo sapiens_hsa003800.77557116
38SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77201726
39DNA replication_Homo sapiens_hsa030300.75882862
40Homologous recombination_Homo sapiens_hsa034400.75326873
41Asthma_Homo sapiens_hsa053100.74322207
42Fanconi anemia pathway_Homo sapiens_hsa034600.72751989
43Base excision repair_Homo sapiens_hsa034100.72174646
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.71745718
45Metabolic pathways_Homo sapiens_hsa011000.70205951
46Fat digestion and absorption_Homo sapiens_hsa049750.68587441
47Basal transcription factors_Homo sapiens_hsa030220.68263289
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.68217898
49Insulin secretion_Homo sapiens_hsa049110.67417945
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.64212516
51Butanoate metabolism_Homo sapiens_hsa006500.61569154
52Retinol metabolism_Homo sapiens_hsa008300.59708231
53Arachidonic acid metabolism_Homo sapiens_hsa005900.59315798
54Chemical carcinogenesis_Homo sapiens_hsa052040.58647000
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58606147
56Steroid biosynthesis_Homo sapiens_hsa001000.57667074
57Mismatch repair_Homo sapiens_hsa034300.49743739
58Collecting duct acid secretion_Homo sapiens_hsa049660.49634542
59Basal cell carcinoma_Homo sapiens_hsa052170.49298237
60Peroxisome_Homo sapiens_hsa041460.49049697
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48984325
62Glycerolipid metabolism_Homo sapiens_hsa005610.48912283
63Cocaine addiction_Homo sapiens_hsa050300.47987059
64beta-Alanine metabolism_Homo sapiens_hsa004100.47540224
65Sulfur metabolism_Homo sapiens_hsa009200.46707809
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46178557
67Nucleotide excision repair_Homo sapiens_hsa034200.45881822
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43312042
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42624065
70Propanoate metabolism_Homo sapiens_hsa006400.42457911
71Fatty acid degradation_Homo sapiens_hsa000710.42168841
72Steroid hormone biosynthesis_Homo sapiens_hsa001400.41274390
73Autoimmune thyroid disease_Homo sapiens_hsa053200.39186313
74Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38652922
75Fatty acid elongation_Homo sapiens_hsa000620.37815577
76Allograft rejection_Homo sapiens_hsa053300.36278864
77Serotonergic synapse_Homo sapiens_hsa047260.35651270
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34232881
79p53 signaling pathway_Homo sapiens_hsa041150.33709159
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.33704177
81Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33197663
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33140678
83Galactose metabolism_Homo sapiens_hsa000520.32986249
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32157166
85Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.32135893
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32042641
87Ether lipid metabolism_Homo sapiens_hsa005650.32041555
88Spliceosome_Homo sapiens_hsa030400.31535704
89RNA transport_Homo sapiens_hsa030130.29933247
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28994469
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.28876933
92Thyroid hormone synthesis_Homo sapiens_hsa049180.26850540
93GABAergic synapse_Homo sapiens_hsa047270.25464629
94Dopaminergic synapse_Homo sapiens_hsa047280.25386831
95Taste transduction_Homo sapiens_hsa047420.23830662
96Glutathione metabolism_Homo sapiens_hsa004800.23135699
97Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.22261523
98Hedgehog signaling pathway_Homo sapiens_hsa043400.20914049
99Ovarian steroidogenesis_Homo sapiens_hsa049130.20753468
100Graft-versus-host disease_Homo sapiens_hsa053320.19659959

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