ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.38727471
2	DNA deamination (GO:0045006)	6.41526210
3	viral transcription (GO:0019083)	6.21134270
4	translational termination (GO:0006415)	5.97862515
5	maturation of SSU-rRNA (GO:0030490)	5.94962707
6	ribosomal small subunit biogenesis (GO:0042274)	5.64024125
7	translational elongation (GO:0006414)	5.22019729
8	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.17776246
9	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.17407618
10	cotranslational protein targeting to membrane (GO:0006613)	5.09088703
11	protein targeting to ER (GO:0045047)	5.05134892
12	protein neddylation (GO:0045116)	4.89837622
13	behavioral response to nicotine (GO:0035095)	4.88825184
14	chaperone-mediated protein transport (GO:0072321)	4.85130134
15	protein localization to endoplasmic reticulum (GO:0070972)	4.83177585
16	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.83062988
17	cytidine deamination (GO:0009972)	4.80692003
18	cytidine metabolic process (GO:0046087)	4.80692003
19	cytidine catabolic process (GO:0006216)	4.80692003
20	cellular protein complex disassembly (GO:0043624)	4.49993372
21	viral life cycle (GO:0019058)	4.46579311
22	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.34043200
23	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.26704037
24	ATP synthesis coupled proton transport (GO:0015986)	4.26704037
25	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.18145568
26	translational initiation (GO:0006413)	4.17657257
27	pyrimidine ribonucleoside catabolic process (GO:0046133)	4.01972242
28	protein complex biogenesis (GO:0070271)	3.95489288
29	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.95444938
30	ribosomal large subunit biogenesis (GO:0042273)	3.86915743
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.84989100
32	NADH dehydrogenase complex assembly (GO:0010257)	3.84989100
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.84989100
34	protein complex disassembly (GO:0043241)	3.79769739
35	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.78742623
36	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.78742623
37	translation (GO:0006412)	3.70676511
38	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.61943521
39	macromolecular complex disassembly (GO:0032984)	3.61753399
40	mitochondrial respiratory chain complex assembly (GO:0033108)	3.61268643
41	pseudouridine synthesis (GO:0001522)	3.47583487
42	cellular component biogenesis (GO:0044085)	3.46288508
43	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.44483363
44	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.38459870
45	ribonucleoprotein complex biogenesis (GO:0022613)	3.35685902
46	protein targeting to membrane (GO:0006612)	3.33335994
47	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.29568164
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.28524706
49	water-soluble vitamin biosynthetic process (GO:0042364)	3.21457680
50	electron transport chain (GO:0022900)	3.19309567
51	respiratory electron transport chain (GO:0022904)	3.17851591
52	GTP biosynthetic process (GO:0006183)	3.14121823
53	positive regulation of T cell apoptotic process (GO:0070234)	3.11283160
54	mRNA catabolic process (GO:0006402)	3.09097819
55	negative regulation of telomere maintenance (GO:0032205)	3.02902767
56	ncRNA 3-end processing (GO:0043628)	2.94888304
57	pyrimidine nucleotide catabolic process (GO:0006244)	2.87671396
58	rRNA processing (GO:0006364)	2.87597704
59	termination of RNA polymerase III transcription (GO:0006386)	2.87345475
60	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.87345475
61	positive regulation of growth hormone secretion (GO:0060124)	2.83301670
62	rRNA metabolic process (GO:0016072)	2.82274332
63	forebrain morphogenesis (GO:0048853)	2.82259008
64	iron-sulfur cluster assembly (GO:0016226)	2.77942869
65	metallo-sulfur cluster assembly (GO:0031163)	2.77942869
66	RNA catabolic process (GO:0006401)	2.77233569
67	DNA demethylation (GO:0080111)	2.75676846
68	response to pheromone (GO:0019236)	2.75049556
69	mannosylation (GO:0097502)	2.74998130
70	rRNA modification (GO:0000154)	2.72465045
71	protein polyglutamylation (GO:0018095)	2.71569755
72	cell proliferation in forebrain (GO:0021846)	2.70461632
73	tRNA processing (GO:0008033)	2.67503585
74	parturition (GO:0007567)	2.67008082
75	UTP biosynthetic process (GO:0006228)	2.66664529
76	protein targeting to mitochondrion (GO:0006626)	2.64651331
77	GPI anchor metabolic process (GO:0006505)	2.64206201
78	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.63046994
79	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.62050829
80	axoneme assembly (GO:0035082)	2.60647449
81	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.59215032
82	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	2.58557147
83	substrate-independent telencephalic tangential migration (GO:0021826)	2.58557147
84	ubiquinone biosynthetic process (GO:0006744)	2.57639504
85	proteasome assembly (GO:0043248)	2.57202466
86	base-excision repair, AP site formation (GO:0006285)	2.57079042
87	establishment of protein localization to mitochondrion (GO:0072655)	2.56487002
88	GPI anchor biosynthetic process (GO:0006506)	2.56293328
89	intracellular protein transmembrane import (GO:0044743)	2.54558487
90	UTP metabolic process (GO:0046051)	2.53308587
91	cytochrome complex assembly (GO:0017004)	2.50609460
92	piRNA metabolic process (GO:0034587)	2.49263406
93	dentate gyrus development (GO:0021542)	2.47037970
94	positive regulation of prostaglandin secretion (GO:0032308)	2.46950352
95	ATP biosynthetic process (GO:0006754)	2.45607357
96	DNA dealkylation (GO:0035510)	2.45589691
97	CTP metabolic process (GO:0046036)	2.45276218
98	CTP biosynthetic process (GO:0006241)	2.45276218
99	guanosine-containing compound biosynthetic process (GO:1901070)	2.43685072
100	protein-cofactor linkage (GO:0018065)	2.42883421

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.97811850
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.47937591
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.34272453
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.14559087
5	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.13818324
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.96294062
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.91178484
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.75104028
9	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.74408127
10	VDR_22108803_ChIP-Seq_LS180_Human	2.64214182
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.49013668
12	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.41523842
13	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.20892552
14	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.20408528
15	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.16307266
16	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.14907503
17	VDR_23849224_ChIP-Seq_CD4+_Human	2.14073874
18	MYC_18940864_ChIP-ChIP_HL60_Human	2.11762124
19	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.99668645
20	FOXP3_21729870_ChIP-Seq_TREG_Human	1.99198331
21	IRF1_19129219_ChIP-ChIP_H3396_Human	1.98558832
22	IGF1R_20145208_ChIP-Seq_DFB_Human	1.97134367
23	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.91580192
24	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.82434298
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78322964
26	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.74108669
27	TTF2_22483619_ChIP-Seq_HELA_Human	1.68264463
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.67742807
29	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.67381823
30	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.62908338
31	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.62575748
32	EWS_26573619_Chip-Seq_HEK293_Human	1.61113910
33	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.60949218
34	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.60360050
35	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59742849
36	ELK1_19687146_ChIP-ChIP_HELA_Human	1.56923772
37	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.55964225
38	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.53148533
39	TP53_22573176_ChIP-Seq_HFKS_Human	1.50442657
40	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.43326915
41	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.40545381
42	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.40354476
43	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.39610786
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38369797
45	GABP_19822575_ChIP-Seq_HepG2_Human	1.37188579
46	FUS_26573619_Chip-Seq_HEK293_Human	1.36882976
47	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.31596397
48	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.28754380
49	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.27921567
50	NCOR_22424771_ChIP-Seq_293T_Human	1.27180588
51	NANOG_20526341_ChIP-Seq_ESCs_Human	1.27114990
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26415570
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.23911550
54	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23383452
55	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.23075920
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22849632
57	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.21873553
58	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.19074798
59	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.18925531
60	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.15882560
61	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15078785
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.14693389
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.14403824
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.14403824
65	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.11995376
66	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.11423638
67	AR_20517297_ChIP-Seq_VCAP_Human	1.11262876
68	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.10826680
69	P300_19829295_ChIP-Seq_ESCs_Human	1.10669056
70	MYC_19829295_ChIP-Seq_ESCs_Human	1.09943439
71	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.09594340
72	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.08879321
73	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.08064043
74	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06033444
75	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06033444
76	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05593735
77	XRN2_22483619_ChIP-Seq_HELA_Human	1.05315949
78	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.05172452
79	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04110660
80	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.03251775
81	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.01848810
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.97620927
83	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.96885242
84	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.96818514
85	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.95960227
86	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.94155769
87	ERA_21632823_ChIP-Seq_H3396_Human	0.93666469
88	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.93601211
89	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.91553184
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90934667
91	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.90849610
92	BCL6_27268052_Chip-Seq_Bcells_Human	0.90792881
93	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.90539480
94	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.89804127
95	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.89406864
96	REST_21632747_ChIP-Seq_MESCs_Mouse	0.86741299
97	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.86377711
98	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.86192606
99	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.85171523
100	P53_21459846_ChIP-Seq_SAOS-2_Human	0.84309962

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	4.54717667
2	MP0006292_abnormal_olfactory_placode	4.03163844
3	MP0003787_abnormal_imprinting	3.47084528
4	MP0008877_abnormal_DNA_methylation	3.37963532
5	MP0002163_abnormal_gland_morphology	2.60125600
6	MP0003123_paternal_imprinting	2.57155395
7	MP0002102_abnormal_ear_morphology	2.55210072
8	MP0005671_abnormal_response_to	2.54134902
9	MP0003646_muscle_fatigue	2.48208328
10	MP0002837_dystrophic_cardiac_calcinosis	2.28248961
11	MP0003122_maternal_imprinting	2.17859417
12	MP0003121_genomic_imprinting	1.91336743
13	MP0001968_abnormal_touch/_nociception	1.88590854
14	MP0008789_abnormal_olfactory_epithelium	1.86963476
15	MP0004142_abnormal_muscle_tone	1.83990234
16	MP0001529_abnormal_vocalization	1.82449914
17	MP0005379_endocrine/exocrine_gland_phen	1.74514704
18	MP0002653_abnormal_ependyma_morphology	1.74225140
19	MP0002736_abnormal_nociception_after	1.65361341
20	MP0001485_abnormal_pinna_reflex	1.64977107
21	MP0002160_abnormal_reproductive_system	1.62135148
22	MP0001188_hyperpigmentation	1.61200829
23	MP0005084_abnormal_gallbladder_morpholo	1.59141110
24	MP0006072_abnormal_retinal_apoptosis	1.57483450
25	MP0001905_abnormal_dopamine_level	1.57301550
26	MP0005645_abnormal_hypothalamus_physiol	1.54968733
27	MP0004147_increased_porphyrin_level	1.54648971
28	MP0006276_abnormal_autonomic_nervous	1.53484333
29	MP0004742_abnormal_vestibular_system	1.51065412
30	MP0001293_anophthalmia	1.49489878
31	MP0003567_abnormal_fetal_cardiomyocyte	1.48988838
32	MP0005389_reproductive_system_phenotype	1.48498422
33	MP0003880_abnormal_central_pattern	1.47761114
34	MP0004145_abnormal_muscle_electrophysio	1.45051129
35	MP0002138_abnormal_hepatobiliary_system	1.42626995
36	MP0005551_abnormal_eye_electrophysiolog	1.42462323
37	MP0008872_abnormal_physiological_respon	1.41703058
38	MP0000049_abnormal_middle_ear	1.31567052
39	MP0008058_abnormal_DNA_repair	1.29928235
40	MP0002876_abnormal_thyroid_physiology	1.22123178
41	MP0005499_abnormal_olfactory_system	1.20751976
42	MP0005394_taste/olfaction_phenotype	1.20751976
43	MP0002095_abnormal_skin_pigmentation	1.19864310
44	MP0003011_delayed_dark_adaptation	1.17849979
45	MP0002272_abnormal_nervous_system	1.16177218
46	MP0001919_abnormal_reproductive_system	1.13053900
47	MP0002638_abnormal_pupillary_reflex	1.12404613
48	MP0000372_irregular_coat_pigmentation	1.11502545
49	MP0002234_abnormal_pharynx_morphology	1.10910373
50	MP0009333_abnormal_splenocyte_physiolog	1.05968126
51	MP0005075_abnormal_melanosome_morpholog	1.04632600
52	MP0005377_hearing/vestibular/ear_phenot	1.04218482
53	MP0003878_abnormal_ear_physiology	1.04218482
54	MP0009745_abnormal_behavioral_response	0.97871730
55	MP0003693_abnormal_embryo_hatching	0.94465873
56	MP0004885_abnormal_endolymph	0.93169685
57	MP0008875_abnormal_xenobiotic_pharmacok	0.92320187
58	MP0005253_abnormal_eye_physiology	0.92246224
59	MP0005410_abnormal_fertilization	0.90622539
60	MP0000631_abnormal_neuroendocrine_gland	0.90464179
61	MP0005646_abnormal_pituitary_gland	0.90452505
62	MP0001764_abnormal_homeostasis	0.88832441
63	MP0000678_abnormal_parathyroid_gland	0.87926897
64	MP0003786_premature_aging	0.87706087
65	MP0001986_abnormal_taste_sensitivity	0.87347298
66	MP0005174_abnormal_tail_pigmentation	0.86826362
67	MP0002210_abnormal_sex_determination	0.84408573
68	MP0009046_muscle_twitch	0.84106458
69	MP0000778_abnormal_nervous_system	0.82804819
70	MP0002148_abnormal_hypersensitivity_rea	0.81036317
71	MP0003186_abnormal_redox_activity	0.80607761
72	MP0002938_white_spotting	0.80475499
73	MP0002067_abnormal_sensory_capabilities	0.79533047
74	MP0001835_abnormal_antigen_presentation	0.79025745
75	MP0005195_abnormal_posterior_eye	0.78805469
76	MP0003806_abnormal_nucleotide_metabolis	0.78509461
77	MP0008995_early_reproductive_senescence	0.77717950
78	MP0002752_abnormal_somatic_nervous	0.77551343
79	MP0001800_abnormal_humoral_immune	0.76969998
80	MP0001963_abnormal_hearing_physiology	0.76698070
81	MP0003718_maternal_effect	0.76310218
82	MP0009785_altered_susceptibility_to	0.75658389
83	MP0006036_abnormal_mitochondrial_physio	0.75422579
84	MP0000026_abnormal_inner_ear	0.74035628
85	MP0001970_abnormal_pain_threshold	0.73804835
86	MP0003763_abnormal_thymus_physiology	0.73751830
87	MP0001119_abnormal_female_reproductive	0.72994298
88	MP0001486_abnormal_startle_reflex	0.72456859
89	MP0002132_abnormal_respiratory_system	0.72017771
90	MP0003195_calcinosis	0.71799550
91	MP0001929_abnormal_gametogenesis	0.71526117
92	MP0002733_abnormal_thermal_nociception	0.70910619
93	MP0002557_abnormal_social/conspecific_i	0.70310014
94	MP0001984_abnormal_olfaction	0.69430016
95	MP0001502_abnormal_circadian_rhythm	0.67817803
96	MP0002693_abnormal_pancreas_physiology	0.67675071
97	MP0002277_abnormal_respiratory_mucosa	0.67221616
98	MP0000653_abnormal_sex_gland	0.66660566
99	MP0001145_abnormal_male_reproductive	0.65646588
100	MP0002723_abnormal_immune_serum	0.64479861

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.10414859
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.22233798
3	Acute necrotizing encephalopathy (HP:0006965)	3.96637240
4	Abnormality of cells of the erythroid lineage (HP:0012130)	3.78169986
5	Mitochondrial inheritance (HP:0001427)	3.66080006
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.61688635
7	Molar tooth sign on MRI (HP:0002419)	3.52899110
8	Abnormality of midbrain morphology (HP:0002418)	3.52899110
9	Acute encephalopathy (HP:0006846)	3.47062367
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.30406759
11	Progressive macrocephaly (HP:0004481)	3.27414024
12	Increased CSF lactate (HP:0002490)	3.16687119
13	Pancreatic fibrosis (HP:0100732)	3.15564130
14	Macrocytic anemia (HP:0001972)	3.10817887
15	Abnormal number of erythroid precursors (HP:0012131)	3.05323922
16	Pancreatic cysts (HP:0001737)	2.97079619
17	Type II lissencephaly (HP:0007260)	2.95465842
18	Pallor (HP:0000980)	2.89321761
19	Increased hepatocellular lipid droplets (HP:0006565)	2.88974920
20	Hepatocellular necrosis (HP:0001404)	2.88634877
21	Abolished electroretinogram (ERG) (HP:0000550)	2.85744426
22	Congenital stationary night blindness (HP:0007642)	2.83042158
23	Cerebral edema (HP:0002181)	2.82116901
24	True hermaphroditism (HP:0010459)	2.79048922
25	Colon cancer (HP:0003003)	2.69899275
26	Aplastic anemia (HP:0001915)	2.68762605
27	Abnormality of DNA repair (HP:0003254)	2.68026491
28	Lipid accumulation in hepatocytes (HP:0006561)	2.64165001
29	Severe combined immunodeficiency (HP:0004430)	2.64098665
30	Hyperglycinemia (HP:0002154)	2.63841006
31	Increased intramyocellular lipid droplets (HP:0012240)	2.61735720
32	3-Methylglutaconic aciduria (HP:0003535)	2.61206577
33	Pendular nystagmus (HP:0012043)	2.59870414
34	Absent thumb (HP:0009777)	2.58080690
35	Hepatic necrosis (HP:0002605)	2.52243759
36	Methylmalonic acidemia (HP:0002912)	2.48290156
37	Metaphyseal dysplasia (HP:0100255)	2.47956630
38	IgG deficiency (HP:0004315)	2.44384558
39	Elevated erythrocyte sedimentation rate (HP:0003565)	2.43640263
40	Methylmalonic aciduria (HP:0012120)	2.40677295
41	Renal Fanconi syndrome (HP:0001994)	2.38484801
42	Nephronophthisis (HP:0000090)	2.37922714
43	Medial flaring of the eyebrow (HP:0010747)	2.34925008
44	Type 2 muscle fiber atrophy (HP:0003554)	2.34259163
45	Optic disc pallor (HP:0000543)	2.34125674
46	Thyroiditis (HP:0100646)	2.28237170
47	Retinal dysplasia (HP:0007973)	2.22819859
48	Abnormality of B cell number (HP:0010975)	2.22331165
49	T lymphocytopenia (HP:0005403)	2.21241121
50	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.20574812
51	B lymphocytopenia (HP:0010976)	2.19816772
52	Sclerocornea (HP:0000647)	2.16915355
53	Increased serum lactate (HP:0002151)	2.16214167
54	Neoplasm of the adrenal cortex (HP:0100641)	2.15529220
55	Panhypogammaglobulinemia (HP:0003139)	2.13821525
56	Abnormality of the labia minora (HP:0012880)	2.12309699
57	Hypoproteinemia (HP:0003075)	2.11693459
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.11380336
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.11380336
60	Increased muscle lipid content (HP:0009058)	2.10964412
61	Stenosis of the external auditory canal (HP:0000402)	2.10694026
62	Lactic acidosis (HP:0003128)	2.09838723
63	Rib fusion (HP:0000902)	2.09397996
64	Muscle fiber atrophy (HP:0100295)	2.07879905
65	Abnormality of T cell number (HP:0011839)	2.07245204
66	Decreased central vision (HP:0007663)	2.06082616
67	Increased IgM level (HP:0003496)	2.05385824
68	Anencephaly (HP:0002323)	2.02191339
69	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.02040582
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99644514
71	Abnormal hemoglobin (HP:0011902)	1.98161662
72	Agitation (HP:0000713)	1.97904474
73	Septo-optic dysplasia (HP:0100842)	1.97390677
74	Asplenia (HP:0001746)	1.94421319
75	Lethargy (HP:0001254)	1.94196055
76	Pancytopenia (HP:0001876)	1.93574082
77	Cystic liver disease (HP:0006706)	1.93425379
78	Horseshoe kidney (HP:0000085)	1.91679035
79	Attenuation of retinal blood vessels (HP:0007843)	1.91416165
80	Combined immunodeficiency (HP:0005387)	1.90296917
81	Abnormal biliary tract physiology (HP:0012439)	1.89686792
82	Bile duct proliferation (HP:0001408)	1.89686792
83	Constricted visual fields (HP:0001133)	1.87697873
84	Tachypnea (HP:0002789)	1.85251071
85	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.84431123
86	Abnormality of serine family amino acid metabolism (HP:0010894)	1.84017126
87	Abnormality of glycine metabolism (HP:0010895)	1.84017126
88	Congenital primary aphakia (HP:0007707)	1.82517280
89	Postaxial foot polydactyly (HP:0001830)	1.82427876
90	Nephrogenic diabetes insipidus (HP:0009806)	1.82336554
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.81353751
92	Absent/shortened dynein arms (HP:0200106)	1.81353751
93	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.80016791
94	Male pseudohermaphroditism (HP:0000037)	1.79516119
95	Abnormality of the renal medulla (HP:0100957)	1.78059915
96	Abnormality of T cells (HP:0002843)	1.77573438
97	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.77488431
98	Gait imbalance (HP:0002141)	1.77393708
99	Depressed nasal ridge (HP:0000457)	1.76011185
100	Neutropenia (HP:0001875)	1.75617190

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.47716607
2	TXK	3.16709564
3	BCKDK	3.04722419
4	ADRBK2	2.90100023
5	VRK2	2.79970285
6	MAP4K2	2.77294131
7	STK16	2.67468040
8	NUAK1	2.46551517
9	GRK1	2.36459793
10	FRK	2.36105989
11	ZAK	2.31232705
12	KDR	2.27894678
13	WNK3	2.26738088
14	WNK4	2.09655661
15	TAOK3	1.92348453
16	DYRK2	1.78804383
17	TAF1	1.62154914
18	VRK1	1.58250961
19	PINK1	1.53846930
20	MAP3K11	1.53048470
21	PASK	1.40275956
22	TESK2	1.37018717
23	PIK3CA	1.36199215
24	PRKCQ	1.27096515
25	CDC7	1.19600849
26	TIE1	1.18252968
27	ITK	1.13861195
28	MAP4K1	1.13019892
29	CSNK1G1	1.04485248
30	MAP2K7	1.04217309
31	TLK1	1.01320551
32	MAPK13	0.98881919
33	TEC	0.97664789
34	PLK4	0.96667902
35	STK39	0.95176055
36	LIMK1	0.94307304
37	NME2	0.89310464
38	CSNK1G2	0.88412120
39	OXSR1	0.88122876
40	BMPR1B	0.86404294
41	CSNK1G3	0.86133535
42	IKBKE	0.85092203
43	KIT	0.82247702
44	DAPK3	0.81533635
45	EPHA4	0.80915678
46	AURKA	0.79193154
47	IKBKB	0.76360791
48	MAP3K4	0.73966931
49	INSRR	0.72250964
50	SYK	0.71959215
51	ADRBK1	0.71785587
52	DAPK1	0.71434136
53	PLK1	0.70322815
54	NEK1	0.69422469
55	RPS6KA5	0.65267523
56	RPS6KA6	0.63790019
57	PIM1	0.63669686
58	MAP3K12	0.62862937
59	NEK2	0.62443343
60	CSNK2A2	0.62077089
61	STK11	0.62070666
62	PRKCG	0.61924036
63	PBK	0.59380260
64	LCK	0.58801444
65	PLK3	0.58733848
66	BTK	0.58671465
67	PRKACA	0.56293840
68	PIM2	0.56178053
69	GRK7	0.55357403
70	BUB1	0.55190918
71	NLK	0.54069559
72	CAMK1	0.53254048
73	DAPK2	0.51099526
74	NME1	0.50959468
75	FES	0.49787718
76	CSNK1A1L	0.49704953
77	LRRK2	0.49575448
78	AURKB	0.47871755
79	CDK3	0.47747248
80	TNIK	0.47367001
81	RPS6KL1	0.47347955
82	RPS6KC1	0.47347955
83	OBSCN	0.47009681
84	CSNK2A1	0.46414703
85	EIF2AK3	0.45566333
86	PRKCH	0.45147415
87	ATR	0.43550641
88	PRKCA	0.42646536
89	LYN	0.42196778
90	PRKCD	0.41957559
91	DYRK1A	0.41802632
92	CHEK2	0.40022408
93	MUSK	0.39754120
94	RPS6KA4	0.38733792
95	CSNK1A1	0.38480360
96	SRPK1	0.38248282
97	ILK	0.38242950
98	PIK3CG	0.36616688
99	TBK1	0.36343725
100	MKNK1	0.35798851

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.59439025
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.53803001
3	Proteasome_Homo sapiens_hsa03050	3.31727545
4	Parkinsons disease_Homo sapiens_hsa05012	3.10017302
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.99075247
6	RNA polymerase_Homo sapiens_hsa03020	2.89040758
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.39755264
8	Huntingtons disease_Homo sapiens_hsa05016	2.11392946
9	Alzheimers disease_Homo sapiens_hsa05010	1.96673570
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.92145112
11	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90997159
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.82652631
13	Protein export_Homo sapiens_hsa03060	1.81465423
14	Phototransduction_Homo sapiens_hsa04744	1.80911803
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.79984972
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.71333357
17	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71249538
18	Homologous recombination_Homo sapiens_hsa03440	1.66904271
19	RNA degradation_Homo sapiens_hsa03018	1.66640434
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.61423544
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.56741822
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.55909384
23	Basal transcription factors_Homo sapiens_hsa03022	1.42090404
24	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41618291
25	Peroxisome_Homo sapiens_hsa04146	1.34293114
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32034260
27	Allograft rejection_Homo sapiens_hsa05330	1.31461021
28	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.30017628
29	Nucleotide excision repair_Homo sapiens_hsa03420	1.29620281
30	DNA replication_Homo sapiens_hsa03030	1.20391679
31	Butanoate metabolism_Homo sapiens_hsa00650	1.20202016
32	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.16542198
33	Asthma_Homo sapiens_hsa05310	1.16336607
34	Propanoate metabolism_Homo sapiens_hsa00640	1.15423482
35	Mismatch repair_Homo sapiens_hsa03430	1.15331441
36	Purine metabolism_Homo sapiens_hsa00230	1.10134606
37	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08239347
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07206867
39	Graft-versus-host disease_Homo sapiens_hsa05332	1.07203913
40	Base excision repair_Homo sapiens_hsa03410	1.06371427
41	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05863844
42	Ether lipid metabolism_Homo sapiens_hsa00565	1.05750668
43	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.05274562
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.04478859
45	Sulfur relay system_Homo sapiens_hsa04122	0.98669889
46	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96422985
47	RNA transport_Homo sapiens_hsa03013	0.95663586
48	Antigen processing and presentation_Homo sapiens_hsa04612	0.94831047
49	Retinol metabolism_Homo sapiens_hsa00830	0.91818571
50	Olfactory transduction_Homo sapiens_hsa04740	0.89825204
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88449545
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88109123
53	One carbon pool by folate_Homo sapiens_hsa00670	0.88070964
54	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.82923432
55	Spliceosome_Homo sapiens_hsa03040	0.82066879
56	Nitrogen metabolism_Homo sapiens_hsa00910	0.80118928
57	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.79682119
58	Caffeine metabolism_Homo sapiens_hsa00232	0.76107358
59	Metabolic pathways_Homo sapiens_hsa01100	0.75960368
60	Nicotine addiction_Homo sapiens_hsa05033	0.75631193
61	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.71638666
62	Chemical carcinogenesis_Homo sapiens_hsa05204	0.71218639
63	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.69701501
64	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.69265469
65	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.67184927
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.65531042
67	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64954317
68	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.63268285
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.61374196
70	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.59672064
71	Non-homologous end-joining_Homo sapiens_hsa03450	0.58792138
72	Sulfur metabolism_Homo sapiens_hsa00920	0.58455283
73	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.57027746
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.56634376
75	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51907100
76	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50085179
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.48880331
78	Fatty acid degradation_Homo sapiens_hsa00071	0.48271690
79	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.47941336
80	Pyruvate metabolism_Homo sapiens_hsa00620	0.46290310
81	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.46010238
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43945498
83	Regulation of autophagy_Homo sapiens_hsa04140	0.41241313
84	Steroid biosynthesis_Homo sapiens_hsa00100	0.40819340
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.40447940
86	Taste transduction_Homo sapiens_hsa04742	0.39768844
87	Fatty acid elongation_Homo sapiens_hsa00062	0.37344684
88	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.36391683
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36059019
90	p53 signaling pathway_Homo sapiens_hsa04115	0.34147475
91	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32635916
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31553151
93	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.30086830
94	Serotonergic synapse_Homo sapiens_hsa04726	0.30010466
95	Glutathione metabolism_Homo sapiens_hsa00480	0.28467707
96	Folate biosynthesis_Homo sapiens_hsa00790	0.28033078
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.26795549
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.24728004
99	Morphine addiction_Homo sapiens_hsa05032	0.22442262
100	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.22340443

RPL7AP30

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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