ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	8.13652502
2	viral transcription (GO:0019083)	7.99848739
3	translational termination (GO:0006415)	7.69131369
4	ribosomal small subunit assembly (GO:0000028)	7.33509798
5	maturation of SSU-rRNA (GO:0030490)	6.67451541
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.45557808
7	translational elongation (GO:0006414)	6.43813294
8	cotranslational protein targeting to membrane (GO:0006613)	6.40095479
9	protein targeting to ER (GO:0045047)	6.34603160
10	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.13756709
11	ATP synthesis coupled proton transport (GO:0015986)	6.13756709
12	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.08053126
13	protein localization to endoplasmic reticulum (GO:0070972)	5.96907224
14	chaperone-mediated protein transport (GO:0072321)	5.91444977
15	cellular protein complex disassembly (GO:0043624)	5.86782094
16	viral life cycle (GO:0019058)	5.67765143
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.48928583
18	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.25292901
19	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.08708206
20	translational initiation (GO:0006413)	5.04147211
21	protein complex disassembly (GO:0043241)	4.97681476
22	macromolecular complex disassembly (GO:0032984)	4.73318997
23	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.52105521
24	respiratory electron transport chain (GO:0022904)	4.48679426
25	protein neddylation (GO:0045116)	4.42645974
26	electron transport chain (GO:0022900)	4.42293421
27	DNA deamination (GO:0045006)	4.30443401
28	protein targeting to membrane (GO:0006612)	4.28807589
29	translation (GO:0006412)	4.28485734
30	substrate-independent telencephalic tangential migration (GO:0021826)	4.19078033
31	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.19078033
32	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.16616247
33	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.16616247
34	NADH dehydrogenase complex assembly (GO:0010257)	4.16616247
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.09367103
36	ribosomal large subunit biogenesis (GO:0042273)	4.04757379
37	ribonucleoprotein complex biogenesis (GO:0022613)	4.00510251
38	pyrimidine nucleotide catabolic process (GO:0006244)	3.99954672
39	nonmotile primary cilium assembly (GO:0035058)	3.97979487
40	protein complex biogenesis (GO:0070271)	3.89432744
41	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.83955067
42	cellular component biogenesis (GO:0044085)	3.80884824
43	ATP biosynthetic process (GO:0006754)	3.75687204
44	mRNA catabolic process (GO:0006402)	3.63323812
45	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.62772474
46	protein-cofactor linkage (GO:0018065)	3.61478460
47	cardiovascular system development (GO:0072358)	3.60049792
48	mitochondrial respiratory chain complex assembly (GO:0033108)	3.56409915
49	cell proliferation in forebrain (GO:0021846)	3.54201239
50	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.54072732
51	protein polyglutamylation (GO:0018095)	3.46233243
52	behavioral response to nicotine (GO:0035095)	3.41820527
53	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.40306565
54	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.39604741
55	termination of RNA polymerase III transcription (GO:0006386)	3.39604741
56	water-soluble vitamin biosynthetic process (GO:0042364)	3.30767652
57	peptidyl-histidine modification (GO:0018202)	3.27313774
58	RNA catabolic process (GO:0006401)	3.25752186
59	hydrogen ion transmembrane transport (GO:1902600)	3.24566907
60	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.23389951
61	GTP biosynthetic process (GO:0006183)	3.21875831
62	protein targeting to mitochondrion (GO:0006626)	3.19653538
63	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.14156050
64	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.11795008
65	pseudouridine synthesis (GO:0001522)	3.10804097
66	ncRNA 3-end processing (GO:0043628)	3.07783008
67	regulation of cilium movement (GO:0003352)	3.05370026
68	phosphatidylserine acyl-chain remodeling (GO:0036150)	3.03393716
69	protein targeting (GO:0006605)	3.01204993
70	establishment of protein localization to mitochondrion (GO:0072655)	3.01165325
71	parturition (GO:0007567)	3.00131096
72	base-excision repair, AP site formation (GO:0006285)	2.99222606
73	proton transport (GO:0015992)	2.97840062
74	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.95444525
75	rRNA processing (GO:0006364)	2.93980486
76	hydrogen transport (GO:0006818)	2.93407582
77	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.93163190
78	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.93163190
79	pyrimidine deoxyribonucleotide metabolic process (GO:0009219)	2.92177043
80	rRNA metabolic process (GO:0016072)	2.91801083
81	establishment of protein localization to membrane (GO:0090150)	2.91342037
82	inner mitochondrial membrane organization (GO:0007007)	2.91125568
83	positive regulation of T cell apoptotic process (GO:0070234)	2.90460038
84	regulation of microtubule-based movement (GO:0060632)	2.88330443
85	hypothalamus development (GO:0021854)	2.84576319
86	UTP metabolic process (GO:0046051)	2.84556273
87	somite development (GO:0061053)	2.81518773
88	tRNA processing (GO:0008033)	2.81399624
89	establishment of protein localization to organelle (GO:0072594)	2.81393667
90	respiratory chain complex IV assembly (GO:0008535)	2.77324847
91	negative regulation of T cell differentiation in thymus (GO:0033085)	2.76575330
92	nucleoside triphosphate biosynthetic process (GO:0009142)	2.74901941
93	deoxyribonucleotide catabolic process (GO:0009264)	2.74164256
94	UTP biosynthetic process (GO:0006228)	2.73007045
95	protein localization to mitochondrion (GO:0070585)	2.72375456
96	intracellular protein transmembrane import (GO:0044743)	2.69451219
97	response to redox state (GO:0051775)	2.61984466
98	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:004316	2.59177111
99	RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)	2.59013175
100	ribosome biogenesis (GO:0042254)	2.58812738

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	5.40483840
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.87562022
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.56006060
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.38672943
5	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.09460776
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.98153229
7	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.94987293
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.86947912
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86755805
10	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.62003581
11	ZNF274_21170338_ChIP-Seq_K562_Hela	2.31915626
12	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.28710044
13	VDR_22108803_ChIP-Seq_LS180_Human	2.27759105
14	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.26897366
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.08584162
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94729605
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.77700759
18	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.76089247
19	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.74246447
20	TTF2_22483619_ChIP-Seq_HELA_Human	1.72917065
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.69842148
22	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.66565041
23	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.66520642
24	XRN2_22483619_ChIP-Seq_HELA_Human	1.65494180
25	VDR_23849224_ChIP-Seq_CD4+_Human	1.64662524
26	GABP_19822575_ChIP-Seq_HepG2_Human	1.62824791
27	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.62670857
28	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.60589146
29	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60410034
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.57659806
31	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.54006104
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.53536462
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.52309622
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.51414213
35	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.51214363
36	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.50088590
37	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.50018195
38	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.48383743
39	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.46631916
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.40034369
41	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37688102
42	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.35993102
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35459723
44	REST_21632747_ChIP-Seq_MESCs_Mouse	1.33084080
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.31142719
46	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.31111581
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28056174
48	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.26675409
49	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.22809752
50	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.20642107
51	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.20629662
52	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.17622433
53	TAF2_19829295_ChIP-Seq_ESCs_Human	1.15557452
54	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.15438372
55	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.14660968
56	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.14536671
57	NCOR_22424771_ChIP-Seq_293T_Human	1.13951879
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.13008885
59	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.12672543
60	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.11342334
61	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.10810385
62	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10664093
63	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.10332305
64	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.08505707
65	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.08251254
66	ELK1_19687146_ChIP-ChIP_HELA_Human	1.08020546
67	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.07780669
68	EWS_26573619_Chip-Seq_HEK293_Human	1.06389462
69	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.05235473
70	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.03075050
71	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.02999826
72	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02236205
73	CIITA_25753668_ChIP-Seq_RAJI_Human	1.02160891
74	ERA_21632823_ChIP-Seq_H3396_Human	1.01713715
75	RNF2_18974828_ChIP-Seq_MESCs_Mouse	0.99115107
76	EZH2_18974828_ChIP-Seq_MESCs_Mouse	0.99115107
77	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.98312434
78	P53_21459846_ChIP-Seq_SAOS-2_Human	0.96753246
79	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.96368875
80	BCL6_27268052_Chip-Seq_Bcells_Human	0.95670549
81	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.95210869
82	CTCF_27219007_Chip-Seq_Bcells_Human	0.94134922
83	CTCF_20526341_ChIP-Seq_ESCs_Human	0.93920756
84	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.93140312
85	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.92921882
86	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.92266420
87	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.91970601
88	RNF2_27304074_Chip-Seq_ESCs_Mouse	0.91414919
89	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.91290699
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.90501783
91	SA1_27219007_Chip-Seq_Bcells_Human	0.88827855
92	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	0.88290805
93	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.87284605
94	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.85937385
95	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.85695707
96	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	0.85561749
97	E2F1_18555785_ChIP-Seq_MESCs_Mouse	0.85496884
98	AR_20517297_ChIP-Seq_VCAP_Human	0.85432404
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.83952032
100	IGF1R_20145208_ChIP-Seq_DFB_Human	0.83618573

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	5.19463231
2	MP0006292_abnormal_olfactory_placode	3.88676078
3	MP0003787_abnormal_imprinting	3.17133588
4	MP0003123_paternal_imprinting	2.70137243
5	MP0008877_abnormal_DNA_methylation	2.47340681
6	MP0003122_maternal_imprinting	2.39565851
7	MP0004885_abnormal_endolymph	2.32823056
8	MP0002163_abnormal_gland_morphology	2.26649898
9	MP0004142_abnormal_muscle_tone	2.14046092
10	MP0004145_abnormal_muscle_electrophysio	2.00725844
11	MP0006276_abnormal_autonomic_nervous	2.00496614
12	MP0003121_genomic_imprinting	1.97479497
13	MP0008789_abnormal_olfactory_epithelium	1.94205141
14	MP0001293_anophthalmia	1.88569348
15	MP0005360_urolithiasis	1.85410250
16	MP0002653_abnormal_ependyma_morphology	1.80440622
17	MP0001968_abnormal_touch/_nociception	1.76948024
18	MP0002160_abnormal_reproductive_system	1.73310111
19	MP0003646_muscle_fatigue	1.73153787
20	MP0002736_abnormal_nociception_after	1.72857802
21	MP0005394_taste/olfaction_phenotype	1.72119604
22	MP0005499_abnormal_olfactory_system	1.72119604
23	MP0005646_abnormal_pituitary_gland	1.64614178
24	MP0001188_hyperpigmentation	1.58747535
25	MP0001529_abnormal_vocalization	1.57993460
26	MP0002638_abnormal_pupillary_reflex	1.55844155
27	MP0005379_endocrine/exocrine_gland_phen	1.54169574
28	MP0008875_abnormal_xenobiotic_pharmacok	1.49940626
29	MP0002272_abnormal_nervous_system	1.49139376
30	MP0003186_abnormal_redox_activity	1.48656111
31	MP0000049_abnormal_middle_ear	1.46501682
32	MP0002234_abnormal_pharynx_morphology	1.46050149
33	MP0000778_abnormal_nervous_system	1.45341334
34	MP0001440_abnormal_grooming_behavior	1.44711843
35	MP0009745_abnormal_behavioral_response	1.42754357
36	MP0002876_abnormal_thyroid_physiology	1.42272007
37	MP0001905_abnormal_dopamine_level	1.40550109
38	MP0005423_abnormal_somatic_nervous	1.39027694
39	MP0002837_dystrophic_cardiac_calcinosis	1.38560763
40	MP0005389_reproductive_system_phenotype	1.37780249
41	MP0002095_abnormal_skin_pigmentation	1.35958622
42	MP0009046_muscle_twitch	1.35887584
43	MP0003011_delayed_dark_adaptation	1.35549146
44	MP0005377_hearing/vestibular/ear_phenot	1.32983886
45	MP0003878_abnormal_ear_physiology	1.32983886
46	MP0004147_increased_porphyrin_level	1.32625170
47	MP0005551_abnormal_eye_electrophysiolog	1.31781962
48	MP0002938_white_spotting	1.29337343
49	MP0002557_abnormal_social/conspecific_i	1.28821304
50	MP0000631_abnormal_neuroendocrine_gland	1.27724893
51	MP0004742_abnormal_vestibular_system	1.25308144
52	MP0001485_abnormal_pinna_reflex	1.25227233
53	MP0005645_abnormal_hypothalamus_physiol	1.23247233
54	MP0001970_abnormal_pain_threshold	1.21443480
55	MP0001919_abnormal_reproductive_system	1.20984780
56	MP0000372_irregular_coat_pigmentation	1.15627945
57	MP0000955_abnormal_spinal_cord	1.13110690
58	MP0002572_abnormal_emotion/affect_behav	1.12638482
59	MP0001984_abnormal_olfaction	1.12175300
60	MP0002733_abnormal_thermal_nociception	1.09990918
61	MP0008872_abnormal_physiological_respon	1.07232257
62	MP0002063_abnormal_learning/memory/cond	1.05399699
63	MP0002102_abnormal_ear_morphology	1.05213857
64	MP0002277_abnormal_respiratory_mucosa	1.04263171
65	MP0002184_abnormal_innervation	1.03098344
66	MP0005195_abnormal_posterior_eye	1.01854897
67	MP0002752_abnormal_somatic_nervous	1.00707482
68	MP0002734_abnormal_mechanical_nocicepti	0.99937279
69	MP0003635_abnormal_synaptic_transmissio	0.98361373
70	MP0006036_abnormal_mitochondrial_physio	0.98100342
71	MP0002138_abnormal_hepatobiliary_system	0.96056694
72	MP0003136_yellow_coat_color	0.94516441
73	MP0003879_abnormal_hair_cell	0.93627921
74	MP0002064_seizures	0.92346563
75	MP0004133_heterotaxia	0.92040583
76	MP0004858_abnormal_nervous_system	0.90908406
77	MP0001986_abnormal_taste_sensitivity	0.90777396
78	MP0000026_abnormal_inner_ear	0.89868258
79	MP0001486_abnormal_startle_reflex	0.83005611
80	MP0003942_abnormal_urinary_system	0.82888474
81	MP0002210_abnormal_sex_determination	0.82477327
82	MP0003937_abnormal_limbs/digits/tail_de	0.82333486
83	MP0002233_abnormal_nose_morphology	0.80998501
84	MP0005084_abnormal_gallbladder_morpholo	0.80839958
85	MP0001348_abnormal_lacrimal_gland	0.80319621
86	MP0002882_abnormal_neuron_morphology	0.79101845
87	MP0002067_abnormal_sensory_capabilities	0.78856690
88	MP0001502_abnormal_circadian_rhythm	0.77842303
89	MP0001324_abnormal_eye_pigmentation	0.76822427
90	MP0000678_abnormal_parathyroid_gland	0.75027382
91	MP0003693_abnormal_embryo_hatching	0.74321058
92	MP0006072_abnormal_retinal_apoptosis	0.74030010
93	MP0000230_abnormal_systemic_arterial	0.73549211
94	MP0003938_abnormal_ear_development	0.73419450
95	MP0005174_abnormal_tail_pigmentation	0.72712593
96	MP0001270_distended_abdomen	0.72276386
97	MP0005671_abnormal_response_to	0.71452101
98	MP0001963_abnormal_hearing_physiology	0.71157153
99	MP0005636_abnormal_mineral_homeostasis	0.70561575
100	MP0002822_catalepsy	0.70429148

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.04359735
2	Acute necrotizing encephalopathy (HP:0006965)	5.00965541
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.66912623
4	Acute encephalopathy (HP:0006846)	4.49895541
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.48871237
6	Progressive macrocephaly (HP:0004481)	4.07154055
7	Abnormal number of erythroid precursors (HP:0012131)	3.98075766
8	Macrocytic anemia (HP:0001972)	3.93003565
9	Mitochondrial inheritance (HP:0001427)	3.90660158
10	Molar tooth sign on MRI (HP:0002419)	3.89861767
11	Abnormality of midbrain morphology (HP:0002418)	3.89861767
12	Increased CSF lactate (HP:0002490)	3.59199908
13	Pancreatic fibrosis (HP:0100732)	3.57946048
14	Pallor (HP:0000980)	3.37208737
15	Congenital stationary night blindness (HP:0007642)	3.36061740
16	Hyperthyroidism (HP:0000836)	3.21991856
17	Pancreatic cysts (HP:0001737)	3.20458054
18	Cerebral edema (HP:0002181)	3.12717535
19	Abnormal hemoglobin (HP:0011902)	3.07163796
20	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.04768110
21	Hepatocellular necrosis (HP:0001404)	2.94613068
22	True hermaphroditism (HP:0010459)	2.92474062
23	Medial flaring of the eyebrow (HP:0010747)	2.85371411
24	Type II lissencephaly (HP:0007260)	2.83699127
25	Sclerocornea (HP:0000647)	2.77661861
26	Hepatic necrosis (HP:0002605)	2.75694099
27	Nephronophthisis (HP:0000090)	2.72733161
28	Optic disc pallor (HP:0000543)	2.69915140
29	Hyperglycinemia (HP:0002154)	2.60628298
30	Anencephaly (HP:0002323)	2.58393646
31	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.51267600
32	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.51267600
33	Myokymia (HP:0002411)	2.46758147
34	Increased hepatocellular lipid droplets (HP:0006565)	2.39673728
35	Renal Fanconi syndrome (HP:0001994)	2.39647627
36	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.38390456
37	Lactic acidosis (HP:0003128)	2.34002394
38	Polydipsia (HP:0001959)	2.33509929
39	Abnormal drinking behavior (HP:0030082)	2.33509929
40	Lipid accumulation in hepatocytes (HP:0006561)	2.31779008
41	Abnormality of alanine metabolism (HP:0010916)	2.31249104
42	Hyperalaninemia (HP:0003348)	2.31249104
43	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.31249104
44	Gait imbalance (HP:0002141)	2.29825635
45	Absent thumb (HP:0009777)	2.28122416
46	Rib fusion (HP:0000902)	2.27127530
47	Increased serum lactate (HP:0002151)	2.27030371
48	Cleft eyelid (HP:0000625)	2.26144873
49	Poor suck (HP:0002033)	2.22862844
50	Lethargy (HP:0001254)	2.19760892
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.19756048
52	Cystic liver disease (HP:0006706)	2.17706750
53	Anophthalmia (HP:0000528)	2.16694939
54	Increased intramyocellular lipid droplets (HP:0012240)	2.14729694
55	Agitation (HP:0000713)	2.11317786
56	Abnormality of the renal medulla (HP:0100957)	2.11080345
57	Congenital primary aphakia (HP:0007707)	2.10695232
58	3-Methylglutaconic aciduria (HP:0003535)	2.10553819
59	Septo-optic dysplasia (HP:0100842)	2.09961746
60	Depressed nasal ridge (HP:0000457)	2.07092805
61	Abnormality of the labia minora (HP:0012880)	2.03138914
62	Respiratory failure (HP:0002878)	2.01869549
63	Leukodystrophy (HP:0002415)	2.00881738
64	Abnormality of magnesium homeostasis (HP:0004921)	1.99705979
65	Chronic hepatic failure (HP:0100626)	1.98399770
66	Truncus arteriosus (HP:0001660)	1.98256104
67	Nephrogenic diabetes insipidus (HP:0009806)	1.96818055
68	Pendular nystagmus (HP:0012043)	1.96579460
69	Concave nail (HP:0001598)	1.96177525
70	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95224493
71	Occipital encephalocele (HP:0002085)	1.92111705
72	Microretrognathia (HP:0000308)	1.85373862
73	Retinal dysplasia (HP:0007973)	1.83102696
74	Hypoplasia of the radius (HP:0002984)	1.82179818
75	Postaxial foot polydactyly (HP:0001830)	1.82084984
76	Increased muscle lipid content (HP:0009058)	1.82036494
77	Maternal diabetes (HP:0009800)	1.81924503
78	Absent/shortened dynein arms (HP:0200106)	1.79507734
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79507734
80	Polyuria (HP:0000103)	1.78514190
81	Male pseudohermaphroditism (HP:0000037)	1.77545221
82	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.77383611
83	Abnormality of renal resorption (HP:0011038)	1.77270685
84	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76137954
85	Polyphagia (HP:0002591)	1.75173771
86	Abnormality of the renal cortex (HP:0011035)	1.74383239
87	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.70264338
88	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.70264338
89	Optic nerve coloboma (HP:0000588)	1.69579025
90	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.68942163
91	Exercise intolerance (HP:0003546)	1.65724554
92	Pachygyria (HP:0001302)	1.65716361
93	Tubular atrophy (HP:0000092)	1.65329264
94	Aganglionic megacolon (HP:0002251)	1.64825795
95	Abnormal number of incisors (HP:0011064)	1.64552671
96	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.64360040
97	Congenital hepatic fibrosis (HP:0002612)	1.64018021
98	Adrenal hypoplasia (HP:0000835)	1.63899257
99	Hypomagnesemia (HP:0002917)	1.63276062
100	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.62733499

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BCKDK	3.60074715
2	NME2	3.27050822
3	TLK1	3.16090234
4	ZAK	3.11611158
5	WNK4	2.63858159
6	ADRBK2	2.60335379
7	MAP4K2	2.56668426
8	DYRK2	2.41445189
9	TXK	2.33469530
10	STK16	2.25102296
11	FRK	2.13375972
12	PDK2	2.05451766
13	GRK1	1.90925823
14	LRRK2	1.89226386
15	TIE1	1.86227006
16	PINK1	1.83878234
17	BMPR1B	1.66916885
18	CAMK1D	1.58557754
19	CAMK1G	1.55935957
20	EPHB2	1.48707179
21	MARK1	1.41859893
22	CDK19	1.41594226
23	CAMKK2	1.40127207
24	CASK	1.38547178
25	ABL2	1.33319803
26	NTRK3	1.32777289
27	MAP3K11	1.32011797
28	PRKCG	1.31150781
29	SIK2	1.30203966
30	NUAK1	1.26657625
31	MAPK13	1.24813905
32	PIK3CA	1.21754437
33	CAMK1	1.13739841
34	MAP2K7	1.08807823
35	PRKCH	1.08260689
36	CAMKK1	1.06820054
37	ADRBK1	1.05359738
38	MAP3K4	1.04683506
39	WNK3	1.03187435
40	STK39	1.01361339
41	LIMK1	1.00774997
42	NTRK2	0.99430894
43	CDC7	0.95889052
44	PNCK	0.93205452
45	PIM2	0.91169381
46	MAP3K9	0.89119613
47	PRKCI	0.86281866
48	CHEK2	0.85568325
49	DMPK	0.84617820
50	AURKA	0.80690602
51	MAP4K1	0.79232578
52	RPS6KA5	0.78964359
53	PRKCQ	0.74137623
54	PLK4	0.74055227
55	PRKACA	0.73450008
56	OXSR1	0.73235551
57	PRKCZ	0.72509453
58	PHKG1	0.71566298
59	PHKG2	0.71566298
60	TAOK3	0.71516213
61	SGK494	0.71377781
62	SGK223	0.71377781
63	RPS6KA6	0.69672880
64	CSNK2A2	0.69647613
65	ARAF	0.68239966
66	DYRK3	0.67990685
67	RPS6KA2	0.65651792
68	INSRR	0.64418986
69	STK11	0.63733762
70	TYRO3	0.62838712
71	ILK	0.62337520
72	DYRK1A	0.57887322
73	CSNK1E	0.54135350
74	ITK	0.52796023
75	PLK1	0.52677697
76	CSNK2A1	0.51321630
77	IKBKB	0.48868603
78	RPS6KL1	0.48672530
79	RPS6KC1	0.48672530
80	DYRK1B	0.48564951
81	CAMK2A	0.48381937
82	PASK	0.48366731
83	TGFBR1	0.47909595
84	WNK1	0.47024315
85	CDK8	0.46582611
86	ATR	0.46089107
87	SGK1	0.45907945
88	PAK3	0.45495672
89	OBSCN	0.44565044
90	BTK	0.44512699
91	PRKD3	0.44215385
92	MINK1	0.43783463
93	MAP2K2	0.43296105
94	BRAF	0.42625777
95	NME1	0.42173223
96	PRKACG	0.39371336
97	TEC	0.39068679
98	AURKB	0.38223061
99	PRKCA	0.38207477
100	SGK3	0.38025299

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.74401893
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.87122203
3	Parkinsons disease_Homo sapiens_hsa05012	4.14175057
4	Huntingtons disease_Homo sapiens_hsa05016	2.97593757
5	RNA polymerase_Homo sapiens_hsa03020	2.82015617
6	Alzheimers disease_Homo sapiens_hsa05010	2.77261045
7	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.75606041
8	Sulfur relay system_Homo sapiens_hsa04122	2.65930434
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.64620220
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.33002298
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29621572
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06000921
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.84644368
14	One carbon pool by folate_Homo sapiens_hsa00670	1.68714198
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.67510863
16	Sulfur metabolism_Homo sapiens_hsa00920	1.59452604
17	Protein export_Homo sapiens_hsa03060	1.57684464
18	Basal transcription factors_Homo sapiens_hsa03022	1.48352831
19	Phototransduction_Homo sapiens_hsa04744	1.46177322
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.45823004
21	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.45308998
22	Proteasome_Homo sapiens_hsa03050	1.33928758
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.32831917
24	RNA degradation_Homo sapiens_hsa03018	1.28434303
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.28292932
26	Homologous recombination_Homo sapiens_hsa03440	1.25135364
27	Nicotine addiction_Homo sapiens_hsa05033	1.19312992
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15304980
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.12849606
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.10755314
31	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.98887082
32	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.97457950
33	Folate biosynthesis_Homo sapiens_hsa00790	0.96999540
34	Tryptophan metabolism_Homo sapiens_hsa00380	0.96763579
35	Purine metabolism_Homo sapiens_hsa00230	0.96106035
36	Butanoate metabolism_Homo sapiens_hsa00650	0.88138336
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.87038445
38	Metabolic pathways_Homo sapiens_hsa01100	0.86238453
39	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84469621
40	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81044056
41	Morphine addiction_Homo sapiens_hsa05032	0.79762267
42	Propanoate metabolism_Homo sapiens_hsa00640	0.78066819
43	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.77698335
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.76605121
45	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76100961
46	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.75306046
47	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.74017202
48	Selenocompound metabolism_Homo sapiens_hsa00450	0.73611140
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.68853599
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.68839953
51	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.67847955
52	Spliceosome_Homo sapiens_hsa03040	0.64614195
53	Peroxisome_Homo sapiens_hsa04146	0.62835765
54	RNA transport_Homo sapiens_hsa03013	0.61178725
55	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.61058237
56	Caffeine metabolism_Homo sapiens_hsa00232	0.60275052
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.58952348
58	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56442908
59	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.55985492
60	Base excision repair_Homo sapiens_hsa03410	0.55320943
61	Insulin secretion_Homo sapiens_hsa04911	0.55012765
62	Serotonergic synapse_Homo sapiens_hsa04726	0.53615890
63	Asthma_Homo sapiens_hsa05310	0.52430095
64	Steroid biosynthesis_Homo sapiens_hsa00100	0.50277289
65	Chemical carcinogenesis_Homo sapiens_hsa05204	0.45331808
66	Glutamatergic synapse_Homo sapiens_hsa04724	0.45104855
67	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.44899405
68	GABAergic synapse_Homo sapiens_hsa04727	0.44586079
69	Basal cell carcinoma_Homo sapiens_hsa05217	0.43524650
70	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41683489
71	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.41615377
72	Olfactory transduction_Homo sapiens_hsa04740	0.40645161
73	DNA replication_Homo sapiens_hsa03030	0.40624876
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.40242866
75	Fatty acid degradation_Homo sapiens_hsa00071	0.40105548
76	Retinol metabolism_Homo sapiens_hsa00830	0.39630918
77	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.39103167
78	Pyruvate metabolism_Homo sapiens_hsa00620	0.39065985
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.35096134
80	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.34437781
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32984752
82	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32142070
83	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.30225729
84	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.28667131
85	Circadian entrainment_Homo sapiens_hsa04713	0.27931352
86	Taste transduction_Homo sapiens_hsa04742	0.27179727
87	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.26704572
88	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.26167286
89	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25736430
90	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25236002
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.24964956
92	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.23278229
93	Mineral absorption_Homo sapiens_hsa04978	0.22850512
94	Dopaminergic synapse_Homo sapiens_hsa04728	0.22192293
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22171407
96	Long-term depression_Homo sapiens_hsa04730	0.18696682
97	Axon guidance_Homo sapiens_hsa04360	0.17651116
98	Mismatch repair_Homo sapiens_hsa03430	0.17307912
99	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.16750960
100	Fatty acid metabolism_Homo sapiens_hsa01212	0.15699279

RPL7AP33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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