ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	antigen processing and presentation via MHC class Ib (GO:0002475)	8.44296029
2	DNA strand renaturation (GO:0000733)	8.14329982
3	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	7.42291516
4	ribosomal small subunit assembly (GO:0000028)	6.31131655
5	DNA deamination (GO:0045006)	6.24259298
6	platelet dense granule organization (GO:0060155)	5.93343714
7	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	5.67080510
8	ribosomal small subunit biogenesis (GO:0042274)	5.61486981
9	viral transcription (GO:0019083)	5.40320148
10	adaptation of signaling pathway (GO:0023058)	5.11991336
11	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	5.03699650
12	translational termination (GO:0006415)	5.03329055
13	maturation of 5.8S rRNA (GO:0000460)	4.97072749
14	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.81409928
15	antigen processing and presentation of endogenous antigen (GO:0019883)	4.72071865
16	protein import into peroxisome matrix (GO:0016558)	4.69963599
17	translational elongation (GO:0006414)	4.55068697
18	ATP synthesis coupled proton transport (GO:0015986)	4.47333557
19	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.47333557
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.44200559
21	cotranslational protein targeting to membrane (GO:0006613)	4.35097972
22	proteasome assembly (GO:0043248)	4.33116303
23	protein targeting to ER (GO:0045047)	4.32369595
24	negative regulation of granulocyte differentiation (GO:0030853)	4.30128127
25	negative regulation of protein oligomerization (GO:0032460)	4.30054224
26	nucleotide transmembrane transport (GO:1901679)	4.19981971
27	cell proliferation in forebrain (GO:0021846)	4.16621892
28	cellular protein complex disassembly (GO:0043624)	4.16435724
29	negative regulation of catenin import into nucleus (GO:0035414)	4.15885459
30	protein localization to endoplasmic reticulum (GO:0070972)	4.09434038
31	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.08733414
32	positive regulation of antigen processing and presentation (GO:0002579)	4.05421530
33	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.97525496
34	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.82565547
35	intracellular protein transmembrane import (GO:0044743)	3.82271785
36	viral life cycle (GO:0019058)	3.81514262
37	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.74252152
38	negative regulation of bone resorption (GO:0045779)	3.68070876
39	ribonucleoprotein complex biogenesis (GO:0022613)	3.53988997
40	regulation of monocyte differentiation (GO:0045655)	3.49427004
41	maturation of SSU-rRNA (GO:0030490)	3.47173704
42	cellular component biogenesis (GO:0044085)	3.44155531
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.42504895
44	ATP biosynthetic process (GO:0006754)	3.41629333
45	protein complex disassembly (GO:0043241)	3.37672465
46	cytidine metabolic process (GO:0046087)	3.33921531
47	cytidine catabolic process (GO:0006216)	3.33921531
48	cytidine deamination (GO:0009972)	3.33921531
49	rRNA catabolic process (GO:0016075)	3.32471883
50	cytolysis (GO:0019835)	3.29453968
51	behavioral response to nicotine (GO:0035095)	3.26677477
52	protein-cofactor linkage (GO:0018065)	3.22242366
53	regulation of protein homooligomerization (GO:0032462)	3.17857869
54	macromolecular complex disassembly (GO:0032984)	3.15936685
55	regulation of isotype switching to IgG isotypes (GO:0048302)	3.13045842
56	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.12319830
57	translational initiation (GO:0006413)	3.10355742
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.07313206
59	positive regulation of B cell differentiation (GO:0045579)	3.05748486
60	T cell migration (GO:0072678)	2.97167152
61	chaperone-mediated protein transport (GO:0072321)	2.96768244
62	respiratory electron transport chain (GO:0022904)	2.94257598
63	electron transport chain (GO:0022900)	2.93983496
64	water-soluble vitamin biosynthetic process (GO:0042364)	2.93610857
65	protein complex biogenesis (GO:0070271)	2.89573588
66	negative regulation of telomere maintenance (GO:0032205)	2.88309775
67	negative regulation of bone remodeling (GO:0046851)	2.88003431
68	translation (GO:0006412)	2.84976526
69	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.83959492
70	termination of RNA polymerase III transcription (GO:0006386)	2.83959492
71	peroxisome organization (GO:0007031)	2.83550766
72	protein localization to peroxisome (GO:0072662)	2.82021792
73	protein targeting to peroxisome (GO:0006625)	2.82021792
74	establishment of protein localization to peroxisome (GO:0072663)	2.82021792
75	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.81116056
76	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.79494816
77	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.78011992
78	regulation of antigen processing and presentation (GO:0002577)	2.77084702
79	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.75784789
80	protein targeting to membrane (GO:0006612)	2.74527055
81	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.74365863
82	intracellular protein transmembrane transport (GO:0065002)	2.71746699
83	regulation of synapse maturation (GO:0090128)	2.69645646
84	negative regulation of multicellular organism growth (GO:0040015)	2.67015387
85	male meiosis I (GO:0007141)	2.66218511
86	protein neddylation (GO:0045116)	2.64595877
87	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.63617676
88	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.63617676
89	NADH dehydrogenase complex assembly (GO:0010257)	2.63617676
90	immunoglobulin mediated immune response (GO:0016064)	2.63203614
91	cellular ketone body metabolic process (GO:0046950)	2.61484803
92	positive regulation of natural killer cell mediated immunity (GO:0002717)	2.59592285
93	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.58409562
94	cellular response to interferon-beta (GO:0035458)	2.54911605
95	cellular response to exogenous dsRNA (GO:0071360)	2.53772472
96	autophagic vacuole fusion (GO:0000046)	2.51185094
97	mitochondrial respiratory chain complex assembly (GO:0033108)	2.49541892
98	peroxisomal transport (GO:0043574)	2.49395168
99	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.48229981
100	spliceosomal snRNP assembly (GO:0000387)	2.46809966

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.12868671
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.11826804
3	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.41700257
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.18486457
5	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.04625545
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.03029550
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.85008656
8	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.76921643
9	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.58391071
10	IKZF1_21737484_ChIP-ChIP_HCT116_Human	2.49170795
11	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.46192598
12	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.44867035
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.40817746
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.39797391
15	VDR_22108803_ChIP-Seq_LS180_Human	2.27971742
16	ZNF274_21170338_ChIP-Seq_K562_Hela	2.15620036
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.10522694
18	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.98813572
19	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95193126
20	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.91977938
21	E2F7_22180533_ChIP-Seq_HELA_Human	1.79728009
22	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.78662408
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.68035342
24	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.67169425
25	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.65300971
26	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.63622794
27	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60376895
28	TAF2_19829295_ChIP-Seq_ESCs_Human	1.59933295
29	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.59750205
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.55328733
31	NANOG_20526341_ChIP-Seq_ESCs_Human	1.53938668
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51733669
33	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	1.47414194
34	NCOR_22424771_ChIP-Seq_293T_Human	1.45026837
35	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.41751409
36	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.41429562
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.39662152
38	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.39662152
39	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.38949032
40	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.37532836
41	VDR_23849224_ChIP-Seq_CD4+_Human	1.37339134
42	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.35871724
43	BCL6_27268052_Chip-Seq_Bcells_Human	1.35557608
44	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33965729
45	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.32779687
46	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.31997367
47	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.31012496
48	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.28636798
49	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.27656445
50	MYC_18940864_ChIP-ChIP_HL60_Human	1.27639003
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26289654
52	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.26083169
53	TP53_22573176_ChIP-Seq_HFKS_Human	1.25991603
54	FOXP3_21729870_ChIP-Seq_TREG_Human	1.24444137
55	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.23051127
56	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21175009
57	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.18832635
58	AR_20517297_ChIP-Seq_VCAP_Human	1.17039465
59	ERA_21632823_ChIP-Seq_H3396_Human	1.16764054
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.14002198
61	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.13244572
62	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.12116724
63	E2F1_20622854_ChIP-Seq_HELA_Human	1.11273453
64	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11191531
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11051770
66	P53_21459846_ChIP-Seq_SAOS-2_Human	1.08491620
67	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.07853038
68	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.07635418
69	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.07465461
70	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.07414467
71	RNF2_27304074_Chip-Seq_NSC_Mouse	1.07104167
72	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.06919399
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.06500491
74	IRF1_19129219_ChIP-ChIP_H3396_Human	1.06345640
75	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.06315976
76	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.04263634
77	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.02910217
78	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.01286077
79	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.01006699
80	SA1_27219007_Chip-Seq_Bcells_Human	0.99545200
81	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99344707
82	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99344707
83	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.99336211
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98931213
85	CTCF_27219007_Chip-Seq_Bcells_Human	0.98652236
86	MYC_19829295_ChIP-Seq_ESCs_Human	0.98079703
87	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.97904395
88	RAC3_21632823_ChIP-Seq_H3396_Human	0.97577191
89	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.95119278
90	SOX2_21211035_ChIP-Seq_LN229_Human	0.94962350
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.93750715
92	P300_27268052_Chip-Seq_Bcells_Human	0.93591160
93	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.93558626
94	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.91313035
95	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.90447353
96	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.90041991
97	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.89639232
98	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.89618756
99	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.87332771
100	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.86517576

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006082_CNS_inflammation	4.15290643
2	MP0005377_hearing/vestibular/ear_phenot	3.99761414
3	MP0003878_abnormal_ear_physiology	3.99761414
4	MP0005671_abnormal_response_to	3.98181401
5	MP0002102_abnormal_ear_morphology	3.80903686
6	MP0002163_abnormal_gland_morphology	3.71380534
7	MP0009379_abnormal_foot_pigmentation	3.59413548
8	MP0002254_reproductive_system_inflammat	3.46639492
9	MP0001873_stomach_inflammation	2.89961874
10	MP0001348_abnormal_lacrimal_gland	2.79884559
11	MP0006292_abnormal_olfactory_placode	2.74962240
12	MP0001835_abnormal_antigen_presentation	2.62221089
13	MP0005379_endocrine/exocrine_gland_phen	2.47530465
14	MP0002837_dystrophic_cardiac_calcinosis	2.24585738
15	MP0005360_urolithiasis	2.18878957
16	MP0003879_abnormal_hair_cell	2.07512508
17	MP0000685_abnormal_immune_system	2.02355614
18	MP0001485_abnormal_pinna_reflex	1.97972269
19	MP0002876_abnormal_thyroid_physiology	1.92553957
20	MP0002132_abnormal_respiratory_system	1.76027651
21	MP0003646_muscle_fatigue	1.75785229
22	MP0002166_altered_tumor_susceptibility	1.66809391
23	MP0005646_abnormal_pituitary_gland	1.57833769
24	MP0009333_abnormal_splenocyte_physiolog	1.57086329
25	MP0004142_abnormal_muscle_tone	1.54282277
26	MP0004742_abnormal_vestibular_system	1.50214647
27	MP0002277_abnormal_respiratory_mucosa	1.47851327
28	MP0003195_calcinosis	1.41628467
29	MP0002933_joint_inflammation	1.41241173
30	MP0003123_paternal_imprinting	1.38244876
31	MP0001919_abnormal_reproductive_system	1.37827173
32	MP0008877_abnormal_DNA_methylation	1.37740846
33	MP0002006_tumorigenesis	1.36751959
34	MP0001984_abnormal_olfaction	1.35430900
35	MP0003787_abnormal_imprinting	1.34262388
36	MP0006276_abnormal_autonomic_nervous	1.32822632
37	MP0008875_abnormal_xenobiotic_pharmacok	1.31343370
38	MP0005084_abnormal_gallbladder_morpholo	1.30520696
39	MP0005551_abnormal_eye_electrophysiolog	1.29287630
40	MP0001346_abnormal_lacrimal_gland	1.28101934
41	MP0005389_reproductive_system_phenotype	1.24702362
42	MP0003122_maternal_imprinting	1.21413365
43	MP0006072_abnormal_retinal_apoptosis	1.20380030
44	MP0000613_abnormal_salivary_gland	1.19668769
45	MP0001968_abnormal_touch/_nociception	1.18700457
46	MP0005645_abnormal_hypothalamus_physiol	1.16730042
47	MP0002736_abnormal_nociception_after	1.16720335
48	MP0008872_abnormal_physiological_respon	1.10121070
49	MP0002272_abnormal_nervous_system	1.07986547
50	MP0001663_abnormal_digestive_system	1.07384544
51	MP0003252_abnormal_bile_duct	1.00942244
52	MP0002160_abnormal_reproductive_system	1.00824091
53	MP0005025_abnormal_response_to	0.99323094
54	MP0001529_abnormal_vocalization	0.98959926
55	MP0001486_abnormal_startle_reflex	0.98929777
56	MP0001119_abnormal_female_reproductive	0.95076947
57	MP0004885_abnormal_endolymph	0.94819246
58	MP0001905_abnormal_dopamine_level	0.94445760
59	MP0000372_irregular_coat_pigmentation	0.94132222
60	MP0002653_abnormal_ependyma_morphology	0.93567973
61	MP0002693_abnormal_pancreas_physiology	0.92528424
62	MP0001800_abnormal_humoral_immune	0.92481771
63	MP0003866_abnormal_defecation	0.91383616
64	MP0002638_abnormal_pupillary_reflex	0.88147318
65	MP0005387_immune_system_phenotype	0.87342148
66	MP0001790_abnormal_immune_system	0.87342148
67	MP0009785_altered_susceptibility_to	0.85792560
68	MP0001440_abnormal_grooming_behavior	0.85041153
69	MP0005000_abnormal_immune_tolerance	0.81694807
70	MP0004145_abnormal_muscle_electrophysio	0.80963101
71	MP0002557_abnormal_social/conspecific_i	0.79702645
72	MP0008789_abnormal_olfactory_epithelium	0.79015956
73	MP0009046_muscle_twitch	0.78629180
74	MP0005085_abnormal_gallbladder_physiolo	0.78212345
75	MP0002420_abnormal_adaptive_immunity	0.77473652
76	MP0003011_delayed_dark_adaptation	0.76699013
77	MP0001293_anophthalmia	0.76490861
78	MP0000631_abnormal_neuroendocrine_gland	0.76163094
79	MP0002723_abnormal_immune_serum	0.74875480
80	MP0001819_abnormal_immune_cell	0.74799253
81	MP0000230_abnormal_systemic_arterial	0.73039023
82	MP0005423_abnormal_somatic_nervous	0.72238451
83	MP0002138_abnormal_hepatobiliary_system	0.71513118
84	MP0010155_abnormal_intestine_physiology	0.70165958
85	MP0001986_abnormal_taste_sensitivity	0.70138041
86	MP0005381_digestive/alimentary_phenotyp	0.68326132
87	MP0002148_abnormal_hypersensitivity_rea	0.66936774
88	MP0009745_abnormal_behavioral_response	0.66933386
89	MP0003121_genomic_imprinting	0.66809415
90	MP0003786_premature_aging	0.66750015
91	MP0003137_abnormal_impulse_conducting	0.65906172
92	MP0005410_abnormal_fertilization	0.65752219
93	MP0005195_abnormal_posterior_eye	0.65718975
94	MP0004019_abnormal_vitamin_homeostasis	0.65311397
95	MP0002210_abnormal_sex_determination	0.64174609
96	MP0002405_respiratory_system_inflammati	0.64062595
97	MP0003763_abnormal_thymus_physiology	0.63393039
98	MP0001188_hyperpigmentation	0.62594219
99	MP0002452_abnormal_antigen_presenting	0.62570536
100	MP0002752_abnormal_somatic_nervous	0.61171520

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Elevated erythrocyte sedimentation rate (HP:0003565)	6.14884520
2	Nasal polyposis (HP:0100582)	5.51575737
3	Chronic otitis media (HP:0000389)	5.44664965
4	Muscle fiber atrophy (HP:0100295)	4.54616593
5	Abnormality of the nasal mucosa (HP:0000433)	4.36823912
6	Chronic sinusitis (HP:0011109)	3.69405093
7	Reticulocytopenia (HP:0001896)	3.58756566
8	Large eyes (HP:0001090)	3.48498205
9	Flat capital femoral epiphysis (HP:0003370)	3.47073291
10	Recurrent bronchitis (HP:0002837)	3.34664098
11	Increased IgM level (HP:0003496)	3.27026675
12	Brushfield spots (HP:0001088)	3.21815061
13	Abnormality of cells of the erythroid lineage (HP:0012130)	3.15808304
14	Asplenia (HP:0001746)	2.97007996
15	Acute necrotizing encephalopathy (HP:0006965)	2.93754976
16	Aplastic anemia (HP:0001915)	2.92461656
17	Rib fusion (HP:0000902)	2.89710183
18	Mitochondrial inheritance (HP:0001427)	2.87226455
19	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.84202910
20	Esophageal atresia (HP:0002032)	2.83447565
21	Abnormal number of erythroid precursors (HP:0012131)	2.79666395
22	Shawl scrotum (HP:0000049)	2.79177058
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.76605097
24	Reduced subcutaneous adipose tissue (HP:0003758)	2.71743863
25	Molar tooth sign on MRI (HP:0002419)	2.65962362
26	Abnormality of midbrain morphology (HP:0002418)	2.65962362
27	Abolished electroretinogram (ERG) (HP:0000550)	2.63368932
28	Increased CSF lactate (HP:0002490)	2.62698193
29	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.60896423
30	Respiratory difficulties (HP:0002880)	2.55739073
31	Abnormal mitochondria in muscle tissue (HP:0008316)	2.54884953
32	Macrocytic anemia (HP:0001972)	2.54117813
33	Stomatitis (HP:0010280)	2.53376704
34	Congenital stationary night blindness (HP:0007642)	2.50637060
35	Methylmalonic acidemia (HP:0002912)	2.49917417
36	Hypergammaglobulinemia (HP:0010702)	2.43764792
37	Pancreatic fibrosis (HP:0100732)	2.37599123
38	Increased hepatocellular lipid droplets (HP:0006565)	2.37009823
39	Acute encephalopathy (HP:0006846)	2.35951746
40	Hypoproteinemia (HP:0003075)	2.35154092
41	Lipid accumulation in hepatocytes (HP:0006561)	2.34493344
42	Cerebellar dysplasia (HP:0007033)	2.32992467
43	True hermaphroditism (HP:0010459)	2.32723195
44	Pendular nystagmus (HP:0012043)	2.32063691
45	Progressive macrocephaly (HP:0004481)	2.31778368
46	Type II lissencephaly (HP:0007260)	2.31337215
47	Polydipsia (HP:0001959)	2.21854303
48	Abnormal drinking behavior (HP:0030082)	2.21854303
49	Methylmalonic aciduria (HP:0012120)	2.21786870
50	Hypomagnesemia (HP:0002917)	2.21707675
51	Abnormal rod and cone electroretinograms (HP:0008323)	2.19757630
52	Hepatocellular necrosis (HP:0001404)	2.16954788
53	Abnormality of magnesium homeostasis (HP:0004921)	2.16177142
54	Atrioventricular block (HP:0001678)	2.14239034
55	Cerebral edema (HP:0002181)	2.10909490
56	Bronchitis (HP:0012387)	2.10426271
57	Pancreatic cysts (HP:0001737)	2.08730113
58	Severe combined immunodeficiency (HP:0004430)	2.06064476
59	Hyperglycinemia (HP:0002154)	2.05587871
60	Renal Fanconi syndrome (HP:0001994)	2.04726533
61	Hepatic necrosis (HP:0002605)	2.04045080
62	Polyuria (HP:0000103)	2.00564573
63	Hemiplegia (HP:0002301)	2.00177681
64	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.98651781
65	Abnormality of B cell number (HP:0010975)	1.98075268
66	Abnormality of the fingertips (HP:0001211)	1.96519592
67	Adrenal hypoplasia (HP:0000835)	1.96400185
68	3-Methylglutaconic aciduria (HP:0003535)	1.95890259
69	Glycosuria (HP:0003076)	1.94255193
70	Abnormality of urine glucose concentration (HP:0011016)	1.94255193
71	Achilles tendon contracture (HP:0001771)	1.92298115
72	IgG deficiency (HP:0004315)	1.91539546
73	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.89327077
74	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.89327077
75	Severe muscular hypotonia (HP:0006829)	1.88312893
76	Increased intramyocellular lipid droplets (HP:0012240)	1.85634058
77	Nephronophthisis (HP:0000090)	1.84288101
78	Large for gestational age (HP:0001520)	1.83968654
79	Autoimmune thrombocytopenia (HP:0001973)	1.83649914
80	Female pseudohermaphroditism (HP:0010458)	1.80638963
81	Bronchiectasis (HP:0002110)	1.80523360
82	Abnormality of the Achilles tendon (HP:0005109)	1.80305243
83	Abnormal urine output (HP:0012590)	1.79132652
84	Absent thumb (HP:0009777)	1.78799771
85	Clubbing of toes (HP:0100760)	1.78391344
86	Lethargy (HP:0001254)	1.78156285
87	Basal ganglia calcification (HP:0002135)	1.77897881
88	Pancytopenia (HP:0001876)	1.76467944
89	Pallor (HP:0000980)	1.76416822
90	Severe visual impairment (HP:0001141)	1.75938848
91	Decreased central vision (HP:0007663)	1.74647826
92	Optic disc pallor (HP:0000543)	1.74322028
93	Thyroiditis (HP:0100646)	1.74199294
94	Heart block (HP:0012722)	1.73885205
95	Erythema (HP:0010783)	1.73429475
96	Agitation (HP:0000713)	1.72918589
97	Attenuation of retinal blood vessels (HP:0007843)	1.72765979
98	Medial flaring of the eyebrow (HP:0010747)	1.72122653
99	Increased serum lactate (HP:0002151)	1.72097133
100	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.71864131

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	GRK7	4.12179462
2	PASK	4.09595136
3	STK16	3.33262586
4	TLK1	3.17094861
5	ZAK	3.14691762
6	BCKDK	2.85477278
7	TXK	2.81591229
8	MOS	2.78079606
9	TGFBR2	2.54166745
10	KDR	2.38722687
11	ADRBK2	2.37186602
12	MAP4K2	2.33273895
13	ITK	2.24402901
14	STK10	2.24281758
15	WNK4	2.20706291
16	GRK5	2.20406516
17	TAOK3	2.00989548
18	NUAK1	1.94712440
19	TESK2	1.91344938
20	FRK	1.86337708
21	GRK1	1.80093925
22	MAP3K13	1.73967174
23	VRK1	1.54255914
24	VRK2	1.41819267
25	DYRK2	1.36976919
26	CAMKK1	1.33128753
27	AURKA	1.31634735
28	TIE1	1.24988016
29	LIMK1	1.22142802
30	LRRK2	1.20323990
31	PRKCQ	1.19494781
32	ADRBK1	1.17291910
33	WNK3	1.12654993
34	MAP3K11	1.06459132
35	MAP3K12	0.98533216
36	INSRR	0.96487816
37	PRKCG	0.91444617
38	LCK	0.90815619
39	EIF2AK2	0.85666047
40	RPS6KA5	0.79362577
41	TESK1	0.79046188
42	NEK1	0.78901132
43	LMTK2	0.76487577
44	IKBKB	0.75415473
45	MAP4K1	0.75040505
46	PINK1	0.73830908
47	CSK	0.71942716
48	PIM1	0.70492404
49	MUSK	0.67719835
50	MAPK13	0.66177103
51	PRKACA	0.64095663
52	TEC	0.63302128
53	SYK	0.60800861
54	STK39	0.60055233
55	NME2	0.60036176
56	MAP2K7	0.58936505
57	FES	0.57844578
58	NTRK2	0.57294929
59	GRK6	0.57238465
60	BMPR1B	0.56935198
61	PTK2	0.55932647
62	KIT	0.55749550
63	PIK3CA	0.54577074
64	LYN	0.51872864
65	MAPK15	0.50567794
66	PKN1	0.49578595
67	IKBKE	0.49341637
68	CSNK1G3	0.49187313
69	OBSCN	0.48763426
70	CDK19	0.47566664
71	DAPK3	0.47440007
72	BTK	0.46995039
73	OXSR1	0.46280773
74	CSNK1G2	0.45753821
75	PRKCD	0.45106944
76	CAMKK2	0.44993929
77	PAK1	0.44317382
78	PRKCA	0.43525128
79	TNK2	0.41821837
80	EPHA2	0.41064208
81	CDC7	0.38860038
82	PLK4	0.38788315
83	CSNK2A2	0.35237549
84	CSNK2A1	0.34043424
85	PRKCH	0.31351678
86	PLK1	0.30947481
87	CSNK1A1	0.30036427
88	EPHA4	0.29872696
89	MAP3K14	0.28980617
90	PDK2	0.28355217
91	PIM2	0.27577109
92	TYRO3	0.27120975
93	CSNK1G1	0.26020061
94	CAMK1	0.25986355
95	PRKACG	0.25818232
96	HCK	0.24832629
97	ABL1	0.24377298
98	PBK	0.23588051
99	MAP2K6	0.23470599
100	SCYL2	0.22552848

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.79325680
2	Primary immunodeficiency_Homo sapiens_hsa05340	3.76745544
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.34157266
4	Parkinsons disease_Homo sapiens_hsa05012	2.72000577
5	Proteasome_Homo sapiens_hsa03050	2.49716956
6	RNA polymerase_Homo sapiens_hsa03020	2.38578894
7	Cardiac muscle contraction_Homo sapiens_hsa04260	2.17253439
8	Huntingtons disease_Homo sapiens_hsa05016	2.01122981
9	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99554532
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.95264657
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82289356
12	Alzheimers disease_Homo sapiens_hsa05010	1.80250963
13	Allograft rejection_Homo sapiens_hsa05330	1.79801841
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.74939100
15	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.72722839
16	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.71907147
17	Graft-versus-host disease_Homo sapiens_hsa05332	1.71268283
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.67779060
19	Phototransduction_Homo sapiens_hsa04744	1.61082949
20	Peroxisome_Homo sapiens_hsa04146	1.53737507
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.52294186
22	Protein export_Homo sapiens_hsa03060	1.47045486
23	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.44654384
24	Retinol metabolism_Homo sapiens_hsa00830	1.43129955
25	Type I diabetes mellitus_Homo sapiens_hsa04940	1.41636382
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.35110715
27	RNA degradation_Homo sapiens_hsa03018	1.31125726
28	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.30470712
29	ABC transporters_Homo sapiens_hsa02010	1.28807164
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.23924281
31	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22007096
32	Sulfur relay system_Homo sapiens_hsa04122	1.21643290
33	Butanoate metabolism_Homo sapiens_hsa00650	1.21080605
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.17134479
35	Caffeine metabolism_Homo sapiens_hsa00232	1.13614773
36	Basal transcription factors_Homo sapiens_hsa03022	1.10846432
37	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.08166637
38	beta-Alanine metabolism_Homo sapiens_hsa00410	1.06789770
39	One carbon pool by folate_Homo sapiens_hsa00670	1.06628644
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.06451122
41	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.06338679
42	Asthma_Homo sapiens_hsa05310	1.05192461
43	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.03527994
44	Mineral absorption_Homo sapiens_hsa04978	1.01918307
45	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01269751
46	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.96553505
47	Purine metabolism_Homo sapiens_hsa00230	0.94622422
48	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94212823
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.94080040
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.91441569
51	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.90272568
52	Tryptophan metabolism_Homo sapiens_hsa00380	0.89344761
53	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.89225008
54	Sulfur metabolism_Homo sapiens_hsa00920	0.88632212
55	Tyrosine metabolism_Homo sapiens_hsa00350	0.88385884
56	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.87552378
57	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.86955639
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.85209143
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84217778
60	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.80041869
61	Fatty acid degradation_Homo sapiens_hsa00071	0.79875356
62	Histidine metabolism_Homo sapiens_hsa00340	0.77499096
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.76947477
64	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.76730237
65	Propanoate metabolism_Homo sapiens_hsa00640	0.74189071
66	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.71947353
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71367198
68	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71134024
69	Homologous recombination_Homo sapiens_hsa03440	0.71023822
70	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.66800751
71	Salivary secretion_Homo sapiens_hsa04970	0.66198495
72	Nicotine addiction_Homo sapiens_hsa05033	0.64219306
73	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.63294286
74	Viral myocarditis_Homo sapiens_hsa05416	0.61507959
75	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.60886711
76	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.60708779
77	Metabolic pathways_Homo sapiens_hsa01100	0.60419219
78	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.59452918
79	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.58216733
80	DNA replication_Homo sapiens_hsa03030	0.57716561
81	Regulation of autophagy_Homo sapiens_hsa04140	0.54992364
82	Olfactory transduction_Homo sapiens_hsa04740	0.53481204
83	Mismatch repair_Homo sapiens_hsa03430	0.52223250
84	Bile secretion_Homo sapiens_hsa04976	0.49319286
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.45799018
86	Rheumatoid arthritis_Homo sapiens_hsa05323	0.45674235
87	Insulin secretion_Homo sapiens_hsa04911	0.42879810
88	Alcoholism_Homo sapiens_hsa05034	0.41155050
89	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.40592758
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37544534
91	Taste transduction_Homo sapiens_hsa04742	0.36872733
92	RNA transport_Homo sapiens_hsa03013	0.35656934
93	Glycerolipid metabolism_Homo sapiens_hsa00561	0.35012957
94	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.33421945
95	Spliceosome_Homo sapiens_hsa03040	0.31883627
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30982391
97	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.30953253
98	Ether lipid metabolism_Homo sapiens_hsa00565	0.30527254
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.28140863
100	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.27781517

RPL7AP34

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »