RPL7AP38

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.29244048
2translational termination (GO:0006415)6.96518546
3ribosomal small subunit biogenesis (GO:0042274)6.86244613
4ribosomal small subunit assembly (GO:0000028)6.77639514
5maturation of SSU-rRNA (GO:0030490)6.62019420
6translational elongation (GO:0006414)5.99403435
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.91940378
8protein targeting to ER (GO:0045047)5.83676779
9cotranslational protein targeting to membrane (GO:0006613)5.82815805
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.62905984
11protein localization to endoplasmic reticulum (GO:0070972)5.61639329
12viral life cycle (GO:0019058)5.45847071
13cellular protein complex disassembly (GO:0043624)5.29995841
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.99452367
15establishment of protein localization to mitochondrial membrane (GO:0090151)4.81982951
16translational initiation (GO:0006413)4.69799490
17tongue development (GO:0043586)4.64601609
18protein complex disassembly (GO:0043241)4.57651765
19macromolecular complex disassembly (GO:0032984)4.48097081
20chaperone-mediated protein transport (GO:0072321)4.40231724
21mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.35123442
22mitochondrial respiratory chain complex I assembly (GO:0032981)4.35123442
23NADH dehydrogenase complex assembly (GO:0010257)4.35123442
24cardiovascular system development (GO:0072358)4.19745888
25pattern specification involved in kidney development (GO:0061004)4.14267046
26water-soluble vitamin biosynthetic process (GO:0042364)3.99831775
27translation (GO:0006412)3.93108009
28protein targeting to membrane (GO:0006612)3.85172701
29ribosomal large subunit biogenesis (GO:0042273)3.83485719
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.81239602
31ATP synthesis coupled proton transport (GO:0015986)3.81239602
32response to gravity (GO:0009629)3.80833619
33protein complex biogenesis (GO:0070271)3.73430020
34cell proliferation in forebrain (GO:0021846)3.62555939
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.54367785
36positive regulation of T cell apoptotic process (GO:0070234)3.52453913
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.39829012
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.38494073
39mRNA catabolic process (GO:0006402)3.38049485
40protein neddylation (GO:0045116)3.33005548
41myoblast migration (GO:0051451)3.29742107
42ribonucleoprotein complex biogenesis (GO:0022613)3.24531976
43ribonucleoprotein complex disassembly (GO:0032988)3.22930726
44auditory receptor cell differentiation (GO:0042491)3.22868893
45mitochondrial respiratory chain complex assembly (GO:0033108)3.20687943
46cellular component biogenesis (GO:0044085)3.19424326
47ovulation cycle (GO:0042698)3.13883278
48behavioral response to nicotine (GO:0035095)3.08145964
49nonmotile primary cilium assembly (GO:0035058)3.06864986
50L-serine metabolic process (GO:0006563)3.06787240
51GTP biosynthetic process (GO:0006183)3.06403594
52nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02164646
53telencephalon development (GO:0021537)3.01769200
54RNA catabolic process (GO:0006401)3.01503287
55cardiac left ventricle morphogenesis (GO:0003214)3.01397649
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.99961412
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.99961412
58mannosylation (GO:0097502)2.94259534
59positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.92679488
60establishment of protein localization to mitochondrion (GO:0072655)2.92355436
61positive regulation of lymphocyte apoptotic process (GO:0070230)2.90794550
62protein targeting to mitochondrion (GO:0006626)2.88583511
63negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.88152241
64protein heterotetramerization (GO:0051290)2.86945823
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84599565
66radial glial cell differentiation (GO:0060019)2.84249043
67establishment of protein localization to membrane (GO:0090150)2.83009518
68respiratory electron transport chain (GO:0022904)2.80445112
69electron transport chain (GO:0022900)2.80343685
70organelle disassembly (GO:1903008)2.78290423
71anterograde synaptic vesicle transport (GO:0048490)2.78017250
72respiratory tube development (GO:0030323)2.77087193
73postsynaptic membrane organization (GO:0001941)2.74884161
74hypothalamus development (GO:0021854)2.74181187
75exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72434027
76positive regulation of natural killer cell differentiation (GO:0032825)2.68958104
77positive regulation of protein homooligomerization (GO:0032464)2.68159443
78regulation of skeletal muscle contraction (GO:0014819)2.67404890
79rRNA catabolic process (GO:0016075)2.66696117
80intraciliary transport (GO:0042073)2.63916434
81cellular response to interferon-beta (GO:0035458)2.60563859
82protein targeting (GO:0006605)2.59564697
83purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.59553089
84purine nucleoside triphosphate biosynthetic process (GO:0009145)2.58730524
85protein peptidyl-prolyl isomerization (GO:0000413)2.58584596
86motile cilium assembly (GO:0044458)2.57189950
87negative regulation of telomere maintenance (GO:0032205)2.55853934
88protein localization to mitochondrion (GO:0070585)2.53252010
89establishment of protein localization to organelle (GO:0072594)2.51937221
90response to xenobiotic stimulus (GO:0009410)2.50957216
91epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50583597
92substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.49713528
93substrate-independent telencephalic tangential migration (GO:0021826)2.49713528
94regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.49056012
95neuron fate determination (GO:0048664)2.47962326
96appendage development (GO:0048736)2.47669603
97limb development (GO:0060173)2.47669603
98UTP biosynthetic process (GO:0006228)2.46603227
99retinal ganglion cell axon guidance (GO:0031290)2.46539301
100ubiquinone biosynthetic process (GO:0006744)2.46142177

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.77664926
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.01482435
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.79315921
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.72191111
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.52433963
6RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20936330
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.11711108
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.03793580
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.83588139
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60643532
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.53089383
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50048594
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.44398952
14CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.24354745
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21280740
16MYC_18555785_ChIP-Seq_MESCs_Mouse1.97611002
17VDR_22108803_ChIP-Seq_LS180_Human1.90928258
18CBX2_27304074_Chip-Seq_ESCs_Mouse1.90605954
19NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.82759237
20POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81806834
21PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.76865056
22EED_16625203_ChIP-ChIP_MESCs_Mouse1.74216705
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70679577
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65464012
25TTF2_22483619_ChIP-Seq_HELA_Human1.65161308
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.64407826
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.60603053
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.57341337
29TP63_19390658_ChIP-ChIP_HaCaT_Human1.57312269
30MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57163440
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54426059
32KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.51757080
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.50940189
34YY1_21170310_ChIP-Seq_MESCs_Mouse1.49923570
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.46447788
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.45664835
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.44762533
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43040692
39EWS_26573619_Chip-Seq_HEK293_Human1.42490344
40FUS_26573619_Chip-Seq_HEK293_Human1.42012978
41VDR_23849224_ChIP-Seq_CD4+_Human1.39438289
42ELK1_19687146_ChIP-ChIP_HELA_Human1.38963866
43FOXP3_21729870_ChIP-Seq_TREG_Human1.38770880
44ELK1_22589737_ChIP-Seq_MCF10A_Human1.38420858
45GABP_19822575_ChIP-Seq_HepG2_Human1.37375461
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.37320487
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36974292
48EZH2_27294783_Chip-Seq_ESCs_Mouse1.36087961
49TP53_20018659_ChIP-ChIP_R1E_Mouse1.35609330
50XRN2_22483619_ChIP-Seq_HELA_Human1.35392562
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.34733250
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.34732891
53ZNF274_21170338_ChIP-Seq_K562_Hela1.32458917
54SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.31108148
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31079312
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29986649
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26950464
58IRF1_19129219_ChIP-ChIP_H3396_Human1.21234088
59E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.21002337
60MYC_18940864_ChIP-ChIP_HL60_Human1.19627120
61MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18836251
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17478202
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.16527230
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16403632
65BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15223086
66EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12856439
67TP53_22573176_ChIP-Seq_HFKS_Human1.12316877
68JARID2_20075857_ChIP-Seq_MESCs_Mouse1.10228007
69RNF2_27304074_Chip-Seq_ESCs_Mouse1.09781064
70RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09771809
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09771809
72REST_21632747_ChIP-Seq_MESCs_Mouse1.09617257
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.09570660
74SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.09394235
75CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.09162230
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.08890085
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.07846903
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06194422
79IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05047123
80NANOG_16153702_ChIP-ChIP_HESCs_Human1.04540495
81SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04408337
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.99156773
83SOX2_18555785_ChIP-Seq_MESCs_Mouse0.99088299
84MYC_19030024_ChIP-ChIP_MESCs_Mouse0.98650966
85ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97540511
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.97104621
87E2F1_18555785_ChIP-Seq_MESCs_Mouse0.95872965
88TAF15_26573619_Chip-Seq_HEK293_Human0.93970802
89P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91605301
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.90941827
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.90762008
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90526677
93TAF2_19829295_ChIP-Seq_ESCs_Human0.89954874
94EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.89930213
95ERA_21632823_ChIP-Seq_H3396_Human0.89750432
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.87657067
97ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87242812
98RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.85805822
99GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85702274
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.85308249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.19875589
2MP0006292_abnormal_olfactory_placode3.83580833
3MP0003122_maternal_imprinting2.79207619
4MP0008789_abnormal_olfactory_epithelium2.76987293
5MP0008877_abnormal_DNA_methylation2.54184236
6MP0004142_abnormal_muscle_tone2.42226782
7MP0001293_anophthalmia2.39584486
8MP0003123_paternal_imprinting2.35358853
9MP0010030_abnormal_orbit_morphology2.34364031
10MP0005423_abnormal_somatic_nervous2.24180136
11MP0003646_muscle_fatigue2.23136792
12MP0002653_abnormal_ependyma_morphology2.10763238
13MP0003121_genomic_imprinting2.03652387
14MP0002277_abnormal_respiratory_mucosa1.95779752
15MP0003136_yellow_coat_color1.93479290
16MP0005499_abnormal_olfactory_system1.84941606
17MP0005394_taste/olfaction_phenotype1.84941606
18MP0003880_abnormal_central_pattern1.84878540
19MP0000049_abnormal_middle_ear1.83653796
20MP0009053_abnormal_anal_canal1.80636591
21MP0006072_abnormal_retinal_apoptosis1.74569819
22MP0003787_abnormal_imprinting1.72770910
23MP0004742_abnormal_vestibular_system1.69966266
24MP0002095_abnormal_skin_pigmentation1.67249920
25MP0008775_abnormal_heart_ventricle1.66571815
26MP0002138_abnormal_hepatobiliary_system1.61670859
27MP0000613_abnormal_salivary_gland1.58877477
28MP0000778_abnormal_nervous_system1.54150417
29MP0004145_abnormal_muscle_electrophysio1.51132334
30MP0002272_abnormal_nervous_system1.48692829
31MP0002163_abnormal_gland_morphology1.47511018
32MP0001968_abnormal_touch/_nociception1.45685387
33MP0000631_abnormal_neuroendocrine_gland1.43617835
34MP0006276_abnormal_autonomic_nervous1.43110285
35MP0009250_abnormal_appendicular_skeleto1.42920543
36MP0004885_abnormal_endolymph1.37525462
37MP0003693_abnormal_embryo_hatching1.33967672
38MP0002736_abnormal_nociception_after1.32859247
39MP0002249_abnormal_larynx_morphology1.32271693
40MP0004133_heterotaxia1.28794039
41MP0002876_abnormal_thyroid_physiology1.25666403
42MP0002233_abnormal_nose_morphology1.25516395
43MP0001984_abnormal_olfaction1.25301891
44MP0000569_abnormal_digit_pigmentation1.23142764
45MP0002938_white_spotting1.22831296
46MP0002177_abnormal_outer_ear1.22562729
47MP0009046_muscle_twitch1.19992331
48MP0001529_abnormal_vocalization1.18771496
49MP0002184_abnormal_innervation1.17905586
50MP0003567_abnormal_fetal_cardiomyocyte1.17474221
51MP0003937_abnormal_limbs/digits/tail_de1.16831591
52MP0003315_abnormal_perineum_morphology1.16777061
53MP0003942_abnormal_urinary_system1.16617085
54MP0005646_abnormal_pituitary_gland1.14241083
55MP0000750_abnormal_muscle_regeneration1.13638704
56MP0009384_cardiac_valve_regurgitation1.13002166
57MP0002735_abnormal_chemical_nociception1.10810113
58MP0005645_abnormal_hypothalamus_physiol1.09387358
59MP0003938_abnormal_ear_development1.06177885
60MP0005195_abnormal_posterior_eye1.03343338
61MP0008872_abnormal_physiological_respon1.01950772
62MP0009745_abnormal_behavioral_response1.01787278
63MP0010368_abnormal_lymphatic_system1.00286326
64MP0001485_abnormal_pinna_reflex1.00068800
65MP0003119_abnormal_digestive_system0.98717524
66MP0001905_abnormal_dopamine_level0.98716364
67MP0002752_abnormal_somatic_nervous0.98660892
68MP0000026_abnormal_inner_ear0.98478730
69MP0002234_abnormal_pharynx_morphology0.97916026
70MP0002572_abnormal_emotion/affect_behav0.97517730
71MP0000647_abnormal_sebaceous_gland0.96795338
72MP0001486_abnormal_startle_reflex0.94346989
73MP0001970_abnormal_pain_threshold0.92535423
74MP0002557_abnormal_social/conspecific_i0.92345570
75MP0002102_abnormal_ear_morphology0.91951617
76MP0001286_abnormal_eye_development0.90501870
77MP0008058_abnormal_DNA_repair0.89610531
78MP0003755_abnormal_palate_morphology0.89452810
79MP0002638_abnormal_pupillary_reflex0.89012910
80MP0001542_abnormal_bone_strength0.88807739
81MP0002733_abnormal_thermal_nociception0.88740224
82MP0001440_abnormal_grooming_behavior0.86947009
83MP0002822_catalepsy0.84215945
84MP0000372_irregular_coat_pigmentation0.81755073
85MP0005377_hearing/vestibular/ear_phenot0.81399288
86MP0003878_abnormal_ear_physiology0.81399288
87MP0001963_abnormal_hearing_physiology0.81033322
88MP0001986_abnormal_taste_sensitivity0.80495504
89MP0002064_seizures0.80157498
90MP0005551_abnormal_eye_electrophysiolog0.78784267
91MP0000566_synostosis0.78358436
92MP0005084_abnormal_gallbladder_morpholo0.77311941
93MP0002160_abnormal_reproductive_system0.76730696
94MP0009764_decreased_sensitivity_to0.76382190
95MP0002697_abnormal_eye_size0.76276464
96MP0008875_abnormal_xenobiotic_pharmacok0.75913258
97MP0005174_abnormal_tail_pigmentation0.73412258
98MP0002116_abnormal_craniofacial_bone0.72338140
99MP0002210_abnormal_sex_determination0.71616138
100MP0002932_abnormal_joint_morphology0.70517816

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.41680204
2Abnormality of cells of the erythroid lineage (HP:0012130)5.28752496
3Acute necrotizing encephalopathy (HP:0006965)4.28736492
4Absent rod-and cone-mediated responses on ERG (HP:0007688)4.14498014
5Stenosis of the external auditory canal (HP:0000402)3.95493570
6Abnormal mitochondria in muscle tissue (HP:0008316)3.82680157
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.74395720
8Septo-optic dysplasia (HP:0100842)3.65890165
9Abnormal number of erythroid precursors (HP:0012131)3.63363097
10Colon cancer (HP:0003003)3.63173288
11Pendular nystagmus (HP:0012043)3.60685290
12Adrenal hypoplasia (HP:0000835)3.54078939
13Molar tooth sign on MRI (HP:0002419)3.53442351
14Abnormality of midbrain morphology (HP:0002418)3.53442351
15Acute encephalopathy (HP:0006846)3.36255058
16Mitochondrial inheritance (HP:0001427)3.31084036
17Progressive macrocephaly (HP:0004481)3.31036552
18Macrocytic anemia (HP:0001972)3.24596879
19Decreased central vision (HP:0007663)3.22997699
20Pancreatic fibrosis (HP:0100732)3.18110620
21Hypoplastic pelvis (HP:0008839)3.14445551
22Type II lissencephaly (HP:0007260)3.12174557
23Increased CSF lactate (HP:0002490)2.98793763
24Abnormal rod and cone electroretinograms (HP:0008323)2.88527897
25True hermaphroditism (HP:0010459)2.81838736
26Focal motor seizures (HP:0011153)2.81195081
27Nephronophthisis (HP:0000090)2.72814219
28Pancreatic cysts (HP:0001737)2.71391814
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.66101313
30Agitation (HP:0000713)2.64465260
31Increased corneal curvature (HP:0100692)2.61443468
32Keratoconus (HP:0000563)2.61443468
33Retinal dysplasia (HP:0007973)2.56121632
34Maternal diabetes (HP:0009800)2.54524976
35Sclerocornea (HP:0000647)2.53280975
3611 pairs of ribs (HP:0000878)2.49470790
37Cerebral edema (HP:0002181)2.48210029
38Short 4th metacarpal (HP:0010044)2.46712015
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.46712015
40Pallor (HP:0000980)2.46104466
41Abnormality of the 4th metacarpal (HP:0010012)2.44720131
42Anencephaly (HP:0002323)2.43649452
43Hepatocellular necrosis (HP:0001404)2.39746881
44Confusion (HP:0001289)2.39092020
45Rib fusion (HP:0000902)2.38975988
46Hypoplasia of the ulna (HP:0003022)2.35858777
47Medial flaring of the eyebrow (HP:0010747)2.35512135
48Aplasia/Hypoplasia of the tongue (HP:0010295)2.32978829
49Optic disc pallor (HP:0000543)2.32956138
50Short femoral neck (HP:0100864)2.30223034
51Hyperglycinemia (HP:0002154)2.28812418
52Depressed nasal ridge (HP:0000457)2.28655598
53Polyphagia (HP:0002591)2.28579365
54Severe visual impairment (HP:0001141)2.27086901
55Oligomenorrhea (HP:0000876)2.24597100
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.23758313
57Abnormality of alanine metabolism (HP:0010916)2.23758313
58Hyperalaninemia (HP:0003348)2.23758313
59Cystic liver disease (HP:0006706)2.22613990
60Cerebellar dysplasia (HP:0007033)2.19509853
61Dynein arm defect of respiratory motile cilia (HP:0012255)2.13090912
62Absent/shortened dynein arms (HP:0200106)2.13090912
63Abnormality of the labia minora (HP:0012880)2.07637038
64Optic nerve hypoplasia (HP:0000609)2.05577638
65Hypoplasia of the radius (HP:0002984)2.03948426
66Delayed CNS myelination (HP:0002188)2.03524341
67Abnormality of reticulocytes (HP:0004312)2.03447629
68Methylmalonic acidemia (HP:0002912)2.03427145
69Hepatic necrosis (HP:0002605)2.02152966
70Postaxial foot polydactyly (HP:0001830)2.01924704
71Tubulointerstitial nephritis (HP:0001970)2.01382515
72Absent septum pellucidum (HP:0001331)2.01119582
73Lipid accumulation in hepatocytes (HP:0006561)2.00735370
74Increased hepatocellular lipid droplets (HP:0006565)1.98724062
75Methylmalonic aciduria (HP:0012120)1.98652148
76Abnormality of the renal medulla (HP:0100957)1.98156592
77Absent thumb (HP:0009777)1.95916414
78Palpebral edema (HP:0100540)1.93753755
79Severe muscular hypotonia (HP:0006829)1.93532087
80Lissencephaly (HP:0001339)1.91788982
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91599759
82Abnormality of the proximal phalanges of the hand (HP:0009834)1.90522709
83Aplasia/Hypoplasia of the ulna (HP:0006495)1.90093794
84Increased serum lactate (HP:0002151)1.89555389
85Abnormality of the phalanges of the 5th finger (HP:0004213)1.89289670
86Hemiparesis (HP:0001269)1.88720101
87Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.88068661
88Forearm undergrowth (HP:0009821)1.87437693
89Leukodystrophy (HP:0002415)1.83904128
90Myokymia (HP:0002411)1.82544105
91Elevated erythrocyte sedimentation rate (HP:0003565)1.82195888
92Holoprosencephaly (HP:0001360)1.80983679
93Status epilepticus (HP:0002133)1.78578101
94Abnormality of serum amino acid levels (HP:0003112)1.76643535
95Hip dysplasia (HP:0001385)1.75838140
96Anterior segment dysgenesis (HP:0007700)1.74806836
97Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.74390457
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.73589938
99Male pseudohermaphroditism (HP:0000037)1.73273198
100Short tibia (HP:0005736)1.72237519

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.84333185
2TIE14.79957918
3VRK23.44503328
4WNK42.79327590
5BCKDK2.52406419
6DYRK22.47238258
7MAP4K22.43317042
8PIK3CA2.09124300
9TAF12.02111201
10PHKG21.94482664
11PHKG11.94482664
12EPHB21.86787875
13STK161.74570348
14CSNK1G31.71747528
15MAP3K111.68527672
16ERBB41.66649774
17CSNK1G11.66381923
18CSNK1A1L1.65892521
19NUAK11.51987474
20LRRK21.49083137
21CSNK1G21.47041631
22NEK11.46491006
23LIMK11.45528242
24STK391.41774897
25VRK11.36129491
26MAP3K121.35072299
27WNK11.29483643
28GRK11.27070654
29CASK1.23938485
30ARAF1.21528118
31CAMK1D1.21401159
32MAPKAPK51.21262099
33MOS1.19100200
34PAK31.18246184
35PINK11.17543460
36TYRO31.10674250
37TLK11.09448841
38AURKA1.04932028
39TEC0.99640226
40PAK60.97533586
41CAMKK20.95477210
42ZAK0.94996231
43DAPK30.92695797
44KSR10.90119501
45CDC70.88885692
46CDK190.88454632
47SRPK10.79874651
48MKNK10.74872411
49ICK0.73502385
50ERN10.72944483
51BRAF0.72578890
52EPHA20.69273358
53PRKCG0.68895008
54CDK70.68016424
55TNIK0.67975868
56NEK20.64176910
57MAP3K90.64097814
58ADRBK20.62465504
59MARK10.62092388
60DAPK10.60643872
61GRK50.60363674
62PIM20.60328547
63ADRBK10.59731725
64PLK10.59384589
65CAMK1G0.56226153
66RAF10.54346468
67CSNK2A20.52113993
68MAP2K70.51862060
69PKN10.51401815
70PRKAA20.50909315
71MINK10.50715346
72CAMK10.49181013
73CSNK1E0.48681186
74CSNK1A10.48221598
75PRKCI0.48046801
76PLK30.47975689
77RPS6KA50.47857923
78EIF2AK20.47241041
79WNK30.47232254
80SMG10.46504922
81AURKB0.46080380
82NTRK30.43310129
83EIF2AK10.42985032
84PRKCQ0.42000363
85PRKACA0.41807004
86MAPK150.41730497
87OBSCN0.41378870
88ATR0.40371093
89NME10.40198428
90SGK10.39733384
91TNK20.39546428
92TXK0.39272242
93ERBB20.39069982
94KSR20.37815276
95BUB10.37152258
96BMPR1B0.36603809
97CCNB10.35962401
98FES0.35782428
99PRKCZ0.35508434
100CDK11A0.34692433

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.86771173
2Oxidative phosphorylation_Homo sapiens_hsa001903.79315322
3Parkinsons disease_Homo sapiens_hsa050123.29163172
4Sulfur relay system_Homo sapiens_hsa041222.70631245
5RNA polymerase_Homo sapiens_hsa030202.70335725
6Cardiac muscle contraction_Homo sapiens_hsa042602.57575737
7Proteasome_Homo sapiens_hsa030502.39759584
8Huntingtons disease_Homo sapiens_hsa050162.35338292
9Alzheimers disease_Homo sapiens_hsa050102.25241853
10Cyanoamino acid metabolism_Homo sapiens_hsa004602.18107226
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06526295
12Phototransduction_Homo sapiens_hsa047441.99151213
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98070873
14Basal transcription factors_Homo sapiens_hsa030221.86505868
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82423836
16RNA degradation_Homo sapiens_hsa030181.74856201
17Protein export_Homo sapiens_hsa030601.69048294
18Hedgehog signaling pathway_Homo sapiens_hsa043401.62879909
19Basal cell carcinoma_Homo sapiens_hsa052171.48614763
20Pyrimidine metabolism_Homo sapiens_hsa002401.42304550
21Homologous recombination_Homo sapiens_hsa034401.40672059
22Nitrogen metabolism_Homo sapiens_hsa009101.30161193
23Nucleotide excision repair_Homo sapiens_hsa034201.29331660
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.23552382
25Linoleic acid metabolism_Homo sapiens_hsa005911.23245565
26One carbon pool by folate_Homo sapiens_hsa006701.20196190
27Mismatch repair_Homo sapiens_hsa034301.20039955
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.08227389
29Butanoate metabolism_Homo sapiens_hsa006501.07857678
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04985967
31Fanconi anemia pathway_Homo sapiens_hsa034601.04706953
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04701049
33Peroxisome_Homo sapiens_hsa041461.03557438
34Caffeine metabolism_Homo sapiens_hsa002321.03537632
35Collecting duct acid secretion_Homo sapiens_hsa049661.03165704
36Glutathione metabolism_Homo sapiens_hsa004800.99673226
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98776440
38Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.91340024
39Purine metabolism_Homo sapiens_hsa002300.91122540
40Propanoate metabolism_Homo sapiens_hsa006400.90487524
41Fatty acid elongation_Homo sapiens_hsa000620.88554243
42Dorso-ventral axis formation_Homo sapiens_hsa043200.88064082
43Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.87320248
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.83732889
45Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.83321885
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81307939
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80467163
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78846441
49Nicotine addiction_Homo sapiens_hsa050330.78676648
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78513748
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.78476020
52Notch signaling pathway_Homo sapiens_hsa043300.76571046
53Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69522289
54Metabolic pathways_Homo sapiens_hsa011000.69119492
55DNA replication_Homo sapiens_hsa030300.68110742
56Arachidonic acid metabolism_Homo sapiens_hsa005900.67402341
57Ether lipid metabolism_Homo sapiens_hsa005650.66429922
58Pyruvate metabolism_Homo sapiens_hsa006200.64920420
59Spliceosome_Homo sapiens_hsa030400.59370930
60Wnt signaling pathway_Homo sapiens_hsa043100.59246265
61RNA transport_Homo sapiens_hsa030130.58609615
62Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58172274
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57423922
64Salivary secretion_Homo sapiens_hsa049700.56392035
65Chemical carcinogenesis_Homo sapiens_hsa052040.56020239
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55565338
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.53510375
68Asthma_Homo sapiens_hsa053100.52243634
69Fat digestion and absorption_Homo sapiens_hsa049750.51028312
70Olfactory transduction_Homo sapiens_hsa047400.50981834
71Glycerolipid metabolism_Homo sapiens_hsa005610.50885412
72Insulin secretion_Homo sapiens_hsa049110.49714533
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47966168
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.47324241
75Biosynthesis of amino acids_Homo sapiens_hsa012300.46333908
76Hippo signaling pathway_Homo sapiens_hsa043900.44925858
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44377838
78Axon guidance_Homo sapiens_hsa043600.44343221
79Oxytocin signaling pathway_Homo sapiens_hsa049210.44026462
80Sulfur metabolism_Homo sapiens_hsa009200.43281580
81Morphine addiction_Homo sapiens_hsa050320.41432274
82Retinol metabolism_Homo sapiens_hsa008300.39762675
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38684367
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38669802
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38312726
86Arginine and proline metabolism_Homo sapiens_hsa003300.35934139
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.34532391
88Melanoma_Homo sapiens_hsa052180.33876875
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33813854
902-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33089918
91p53 signaling pathway_Homo sapiens_hsa041150.32957822
92Starch and sucrose metabolism_Homo sapiens_hsa005000.32829112
93Tryptophan metabolism_Homo sapiens_hsa003800.30455382
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29290956
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.28636953
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.27424554
97Galactose metabolism_Homo sapiens_hsa000520.26734591
98beta-Alanine metabolism_Homo sapiens_hsa004100.26259175
99Carbon metabolism_Homo sapiens_hsa012000.24757839
100Fatty acid degradation_Homo sapiens_hsa000710.24548415

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