RPL7AP4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.69431810
2viral transcription (GO:0019083)7.19661672
3translational termination (GO:0006415)6.90966982
4SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.16069787
5cotranslational protein targeting to membrane (GO:0006613)6.06717176
6protein targeting to ER (GO:0045047)6.02982487
7translational elongation (GO:0006414)5.95100486
8DNA deamination (GO:0045006)5.80767995
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.76449177
10protein localization to endoplasmic reticulum (GO:0070972)5.67942381
11ribosomal small subunit biogenesis (GO:0042274)5.49081647
12cellular protein complex disassembly (GO:0043624)5.35788851
13energy coupled proton transport, down electrochemical gradient (GO:0015985)5.33008280
14ATP synthesis coupled proton transport (GO:0015986)5.33008280
15viral life cycle (GO:0019058)5.20358907
16mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.98887404
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97956119
18maturation of SSU-rRNA (GO:0030490)4.91450702
19chaperone-mediated protein transport (GO:0072321)4.90059577
20nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.85681724
21translational initiation (GO:0006413)4.80153524
22ribosomal large subunit biogenesis (GO:0042273)4.61253163
23protein complex disassembly (GO:0043241)4.41348228
24translation (GO:0006412)4.29897447
25macromolecular complex disassembly (GO:0032984)4.18145571
26respiratory electron transport chain (GO:0022904)4.09376959
27protein complex biogenesis (GO:0070271)4.07116711
28electron transport chain (GO:0022900)4.05169661
29establishment of protein localization to mitochondrial membrane (GO:0090151)4.03503358
30protein targeting to membrane (GO:0006612)3.96130336
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.93737885
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.88579359
33mitochondrial respiratory chain complex I assembly (GO:0032981)3.81814987
34NADH dehydrogenase complex assembly (GO:0010257)3.81814987
35mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.81814987
36nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.75374377
37nonmotile primary cilium assembly (GO:0035058)3.72527196
38nuclear-transcribed mRNA catabolic process (GO:0000956)3.69941452
39mitochondrial respiratory chain complex assembly (GO:0033108)3.68306805
40substrate-independent telencephalic tangential migration (GO:0021826)3.62858323
41substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.62858323
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.61865687
43ribonucleoprotein complex biogenesis (GO:0022613)3.53728886
44cellular component biogenesis (GO:0044085)3.52142052
45cytidine deamination (GO:0009972)3.50554718
46cytidine metabolic process (GO:0046087)3.50554718
47cytidine catabolic process (GO:0006216)3.50554718
48mRNA catabolic process (GO:0006402)3.50318108
49preassembly of GPI anchor in ER membrane (GO:0016254)3.42098337
50response to pheromone (GO:0019236)3.39833127
51purine nucleoside triphosphate biosynthetic process (GO:0009145)3.33348242
52ATP biosynthetic process (GO:0006754)3.31101780
53purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.29511804
54epithelial cilium movement (GO:0003351)3.28530874
55regulation of mitochondrial translation (GO:0070129)3.26372879
56GTP biosynthetic process (GO:0006183)3.24476878
57sequestering of actin monomers (GO:0042989)3.23685342
58RNA catabolic process (GO:0006401)3.23502202
59pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.21844688
60protein-cofactor linkage (GO:0018065)3.18080120
61cytochrome complex assembly (GO:0017004)3.10248997
62pyrimidine ribonucleoside catabolic process (GO:0046133)3.09646741
63respiratory chain complex IV assembly (GO:0008535)3.08114523
64protein neddylation (GO:0045116)3.07125438
65ncRNA catabolic process (GO:0034661)3.06593740
66proteasome assembly (GO:0043248)2.98639622
67UTP metabolic process (GO:0046051)2.97718542
68oxidative phosphorylation (GO:0006119)2.95188326
69segment specification (GO:0007379)2.93430529
70water-soluble vitamin biosynthetic process (GO:0042364)2.92274458
71positive regulation of respiratory burst (GO:0060267)2.86971823
72ribonucleoside triphosphate biosynthetic process (GO:0009201)2.84389653
73mannosylation (GO:0097502)2.81994433
74negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.79906653
75pyrimidine nucleotide catabolic process (GO:0006244)2.79581384
76ubiquinone biosynthetic process (GO:0006744)2.79170060
77chromatin remodeling at centromere (GO:0031055)2.77988069
78maturation of 5.8S rRNA (GO:0000460)2.76806110
79peptidyl-histidine modification (GO:0018202)2.76622533
80auditory receptor cell differentiation (GO:0042491)2.75671421
81hydrogen ion transmembrane transport (GO:1902600)2.74884223
82rRNA processing (GO:0006364)2.72463334
83somite development (GO:0061053)2.70773732
84GMP metabolic process (GO:0046037)2.70382831
85rRNA metabolic process (GO:0016072)2.69619009
86protein targeting (GO:0006605)2.68319813
87axonemal dynein complex assembly (GO:0070286)2.67711529
88UTP biosynthetic process (GO:0006228)2.67559620
89termination of RNA polymerase III transcription (GO:0006386)2.61308242
90transcription elongation from RNA polymerase III promoter (GO:0006385)2.61308242
91RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.60686708
92tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.60686708
93ubiquinone metabolic process (GO:0006743)2.59355167
94guanosine-containing compound biosynthetic process (GO:1901070)2.58538920
95establishment of protein localization to membrane (GO:0090150)2.57617926
96proton transport (GO:0015992)2.56234105
97GPI anchor biosynthetic process (GO:0006506)2.55882702
98piRNA metabolic process (GO:0034587)2.55876587
99branched-chain amino acid catabolic process (GO:0009083)2.53945649
100protein targeting to mitochondrion (GO:0006626)2.52639114

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.43894602
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.34051164
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.85081371
4HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.24547928
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.22524767
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.17583025
7ZNF274_21170338_ChIP-Seq_K562_Hela2.96490759
8VDR_22108803_ChIP-Seq_LS180_Human2.92170267
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90224634
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65975852
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56755616
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.54319120
13MYC_18555785_ChIP-Seq_MESCs_Mouse2.50507585
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49101647
15EZH2_22144423_ChIP-Seq_EOC_Human2.43913424
16VDR_23849224_ChIP-Seq_CD4+_Human2.43117802
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40175867
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38302277
19ELK1_19687146_ChIP-ChIP_HELA_Human2.20866762
20FOXP3_21729870_ChIP-Seq_TREG_Human2.15627256
21HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07985425
22TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.07488621
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01347207
24MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96316575
25MYC_18940864_ChIP-ChIP_HL60_Human1.94706763
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92348704
27SRF_21415370_ChIP-Seq_HL-1_Mouse1.90846926
28TTF2_22483619_ChIP-Seq_HELA_Human1.82154635
29IGF1R_20145208_ChIP-Seq_DFB_Human1.68352916
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67346478
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62008947
32TP53_22573176_ChIP-Seq_HFKS_Human1.55221942
33GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.52104963
34EWS_26573619_Chip-Seq_HEK293_Human1.46118383
35XRN2_22483619_ChIP-Seq_HELA_Human1.44763316
36MYC_19079543_ChIP-ChIP_MESCs_Mouse1.42052011
37GABP_19822575_ChIP-Seq_HepG2_Human1.39979808
38MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38569967
39YY1_21170310_ChIP-Seq_MESCs_Mouse1.38541190
40CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.36734868
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36332163
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.34695965
43POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34338123
44IRF1_19129219_ChIP-ChIP_H3396_Human1.33692623
45NANOG_20526341_ChIP-Seq_ESCs_Human1.32350558
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.30434926
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.30348564
48NCOR_22424771_ChIP-Seq_293T_Human1.26328522
49POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23650422
50ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22768299
51SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18271310
52FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17226616
53CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.16350711
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16041998
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.12101825
56AR_20517297_ChIP-Seq_VCAP_Human1.11907124
57TAF2_19829295_ChIP-Seq_ESCs_Human1.11603406
58PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10690213
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10587013
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.10268913
61FUS_26573619_Chip-Seq_HEK293_Human1.10261349
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09471251
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.08945855
64GATA3_21878914_ChIP-Seq_MCF-7_Human1.08527127
65RNF2_27304074_Chip-Seq_NSC_Mouse1.08461187
66AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08194488
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.08057742
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08057742
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.07952582
70MYC_19829295_ChIP-Seq_ESCs_Human1.07511338
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07111334
72BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04243817
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03179900
74SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.02992073
75ERA_21632823_ChIP-Seq_H3396_Human1.02210490
76RBPJ_22232070_ChIP-Seq_NCS_Mouse1.01327260
77EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00749003
78DCP1A_22483619_ChIP-Seq_HELA_Human0.99822061
79ELK1_22589737_ChIP-Seq_MCF10A_Human0.99600344
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98100941
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98012867
82CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97051941
83P300_19829295_ChIP-Seq_ESCs_Human0.96860755
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95597943
85MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95426935
86SOX2_16153702_ChIP-ChIP_HESCs_Human0.95290436
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94003622
88SOX2_19829295_ChIP-Seq_ESCs_Human0.93981173
89NANOG_19829295_ChIP-Seq_ESCs_Human0.93981173
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.92988100
91P53_21459846_ChIP-Seq_SAOS-2_Human0.92666602
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92375093
93BCAT_22108803_ChIP-Seq_LS180_Human0.92034538
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91978040
95PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91807773
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91184736
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.90264125
98HTT_18923047_ChIP-ChIP_STHdh_Human0.87107981
99EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87090150
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86771083

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.78392914
2MP0006292_abnormal_olfactory_placode4.23159101
3MP0008789_abnormal_olfactory_epithelium2.58347403
4MP0005360_urolithiasis2.54062000
5MP0002653_abnormal_ependyma_morphology2.49127995
6MP0000372_irregular_coat_pigmentation2.45048800
7MP0008877_abnormal_DNA_methylation2.33927404
8MP0002938_white_spotting2.32593811
9MP0001293_anophthalmia2.28677362
10MP0002837_dystrophic_cardiac_calcinosis2.15535638
11MP0003123_paternal_imprinting2.01073423
12MP0003787_abnormal_imprinting1.96816369
13MP0001529_abnormal_vocalization1.95832884
14MP0006276_abnormal_autonomic_nervous1.94165676
15MP0005075_abnormal_melanosome_morpholog1.90111666
16MP0003878_abnormal_ear_physiology1.89565041
17MP0005377_hearing/vestibular/ear_phenot1.89565041
18MP0004885_abnormal_endolymph1.85970513
19MP0005394_taste/olfaction_phenotype1.83321329
20MP0005499_abnormal_olfactory_system1.83321329
21MP0002102_abnormal_ear_morphology1.79188578
22MP0006072_abnormal_retinal_apoptosis1.78395084
23MP0005084_abnormal_gallbladder_morpholo1.75562762
24MP0003122_maternal_imprinting1.74538735
25MP0004142_abnormal_muscle_tone1.67953031
26MP0004133_heterotaxia1.63905523
27MP0005174_abnormal_tail_pigmentation1.63888311
28MP0002163_abnormal_gland_morphology1.62689330
29MP0002095_abnormal_skin_pigmentation1.50640685
30MP0005645_abnormal_hypothalamus_physiol1.50628783
31MP0003806_abnormal_nucleotide_metabolis1.50254836
32MP0005551_abnormal_eye_electrophysiolog1.50165690
33MP0001485_abnormal_pinna_reflex1.50002108
34MP0005379_endocrine/exocrine_gland_phen1.47671434
35MP0005423_abnormal_somatic_nervous1.43243229
36MP0002234_abnormal_pharynx_morphology1.37201143
37MP0003121_genomic_imprinting1.35757972
38MP0005671_abnormal_response_to1.30108059
39MP0002277_abnormal_respiratory_mucosa1.28838659
40MP0009333_abnormal_splenocyte_physiolog1.28623685
41MP0008872_abnormal_physiological_respon1.25919114
42MP0003195_calcinosis1.24992234
43MP0003693_abnormal_embryo_hatching1.24837588
44MP0003880_abnormal_central_pattern1.23699441
45MP0003937_abnormal_limbs/digits/tail_de1.19699577
46MP0000049_abnormal_middle_ear1.17429038
47MP0003011_delayed_dark_adaptation1.17242834
48MP0003567_abnormal_fetal_cardiomyocyte1.16561346
49MP0004147_increased_porphyrin_level1.15274645
50MP0005253_abnormal_eye_physiology1.13942495
51MP0001968_abnormal_touch/_nociception1.10775687
52MP0001986_abnormal_taste_sensitivity1.10124360
53MP0003186_abnormal_redox_activity1.09362290
54MP0006036_abnormal_mitochondrial_physio1.07212426
55MP0008058_abnormal_DNA_repair1.06258693
56MP0005408_hypopigmentation1.05583873
57MP0008995_early_reproductive_senescence1.04766182
58MP0002736_abnormal_nociception_after1.03264083
59MP0002272_abnormal_nervous_system1.03042416
60MP0002233_abnormal_nose_morphology1.02613389
61MP0002160_abnormal_reproductive_system1.02359776
62MP0008875_abnormal_xenobiotic_pharmacok0.95606270
63MP0001905_abnormal_dopamine_level0.95500978
64MP0001764_abnormal_homeostasis0.95213610
65MP0004858_abnormal_nervous_system0.95017608
66MP0010030_abnormal_orbit_morphology0.94340944
67MP0003119_abnormal_digestive_system0.93675637
68MP0008007_abnormal_cellular_replicative0.92781132
69MP0000631_abnormal_neuroendocrine_gland0.92556246
70MP0002752_abnormal_somatic_nervous0.92308976
71MP0005389_reproductive_system_phenotype0.90912141
72MP0005085_abnormal_gallbladder_physiolo0.89224305
73MP0002210_abnormal_sex_determination0.89116720
74MP0003646_muscle_fatigue0.88819013
75MP0004145_abnormal_muscle_electrophysio0.88612096
76MP0002557_abnormal_social/conspecific_i0.87811260
77MP0000026_abnormal_inner_ear0.87788622
78MP0002184_abnormal_innervation0.86990118
79MP0003786_premature_aging0.85666953
80MP0005195_abnormal_posterior_eye0.84400387
81MP0005646_abnormal_pituitary_gland0.84229006
82MP0001963_abnormal_hearing_physiology0.83914187
83MP0005391_vision/eye_phenotype0.82129477
84MP0003938_abnormal_ear_development0.80635987
85MP0005332_abnormal_amino_acid0.79077561
86MP0002138_abnormal_hepatobiliary_system0.78141481
87MP0001944_abnormal_pancreas_morphology0.76569852
88MP0003315_abnormal_perineum_morphology0.76395702
89MP0000778_abnormal_nervous_system0.75517251
90MP0001919_abnormal_reproductive_system0.74492664
91MP0006035_abnormal_mitochondrial_morpho0.74101674
92MP0003137_abnormal_impulse_conducting0.72251081
93MP0005636_abnormal_mineral_homeostasis0.70052805
94MP0001929_abnormal_gametogenesis0.69708367
95MP0002638_abnormal_pupillary_reflex0.69440798
96MP0002751_abnormal_autonomic_nervous0.67926181
97MP0001984_abnormal_olfaction0.67832031
98MP0001324_abnormal_eye_pigmentation0.66535050
99MP0009745_abnormal_behavioral_response0.64145371
100MP0001145_abnormal_male_reproductive0.63761090

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)5.07947773
2Acute necrotizing encephalopathy (HP:0006965)4.67859306
3Molar tooth sign on MRI (HP:0002419)4.34151700
4Abnormality of midbrain morphology (HP:0002418)4.34151700
5Acute encephalopathy (HP:0006846)4.16389164
6Mitochondrial inheritance (HP:0001427)4.06186507
7Abnormal mitochondria in muscle tissue (HP:0008316)4.00711887
8Progressive macrocephaly (HP:0004481)3.75965671
9Abnormality of cells of the erythroid lineage (HP:0012130)3.67925805
10Pancreatic fibrosis (HP:0100732)3.62697228
11Increased CSF lactate (HP:0002490)3.58841231
12Cerebral edema (HP:0002181)3.54842132
13Pancreatic cysts (HP:0001737)3.50193878
14True hermaphroditism (HP:0010459)3.40584662
15Dynein arm defect of respiratory motile cilia (HP:0012255)3.34457851
16Absent/shortened dynein arms (HP:0200106)3.34457851
17Abnormal number of erythroid precursors (HP:0012131)3.32461124
18Macrocytic anemia (HP:0001972)3.31525239
19Hepatocellular necrosis (HP:0001404)3.30458592
20Nephronophthisis (HP:0000090)3.14262611
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.07780808
22Hepatic necrosis (HP:0002605)2.96176482
23Optic disc pallor (HP:0000543)2.95093832
24Medial flaring of the eyebrow (HP:0010747)2.90883402
25Congenital stationary night blindness (HP:0007642)2.87069238
26Sclerocornea (HP:0000647)2.71115892
27Elevated erythrocyte sedimentation rate (HP:0003565)2.66947762
283-Methylglutaconic aciduria (HP:0003535)2.65664118
29Abnormal respiratory motile cilium morphology (HP:0005938)2.65600555
30Abnormal respiratory epithelium morphology (HP:0012253)2.65600555
31Type I transferrin isoform profile (HP:0003642)2.64590978
32Abnormal rod and cone electroretinograms (HP:0008323)2.61906352
33Increased hepatocellular lipid droplets (HP:0006565)2.54178915
34Abnormal ciliary motility (HP:0012262)2.51395624
35Anencephaly (HP:0002323)2.50527172
36Hyperglycinemia (HP:0002154)2.48640125
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.46644937
38Lethargy (HP:0001254)2.43685928
39Lipid accumulation in hepatocytes (HP:0006561)2.43507766
40Colon cancer (HP:0003003)2.41431734
41Abnormality of the renal medulla (HP:0100957)2.39967386
42Absent thumb (HP:0009777)2.39928890
43Lactic acidosis (HP:0003128)2.38773886
44Cystic liver disease (HP:0006706)2.34899423
45Aplasia/Hypoplasia of the tongue (HP:0010295)2.31997235
46Abnormality of the labia minora (HP:0012880)2.27683926
47Renal Fanconi syndrome (HP:0001994)2.26355191
48Increased serum lactate (HP:0002151)2.21794866
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.19739283
50Septo-optic dysplasia (HP:0100842)2.18719597
51Abnormal glycosylation (HP:0012345)2.16192981
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.16192981
53Abnormal protein N-linked glycosylation (HP:0012347)2.16192981
54Abnormal protein glycosylation (HP:0012346)2.16192981
55Methylmalonic aciduria (HP:0012120)2.16036345
56Type 2 muscle fiber atrophy (HP:0003554)2.15510608
57Abnormal respiratory motile cilium physiology (HP:0012261)2.14262777
58Pallor (HP:0000980)2.13786822
59Pendular nystagmus (HP:0012043)2.11922350
60Asplenia (HP:0001746)2.10890007
61Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.09910020
62Congenital hepatic fibrosis (HP:0002612)2.09342516
63Respiratory failure (HP:0002878)2.05995157
64Abnormality of magnesium homeostasis (HP:0004921)2.05836513
65Hyperglycinuria (HP:0003108)2.05757841
66Supernumerary spleens (HP:0009799)2.04226818
67Adrenal hypoplasia (HP:0000835)2.03148880
68Congenital primary aphakia (HP:0007707)2.02782158
69Gait imbalance (HP:0002141)1.99810231
70Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.99320094
71Abnormality of glycine metabolism (HP:0010895)1.97240437
72Abnormality of serine family amino acid metabolism (HP:0010894)1.97240437
73Abnormal drinking behavior (HP:0030082)1.96818316
74Polydipsia (HP:0001959)1.96818316
75Postaxial foot polydactyly (HP:0001830)1.94810596
76Nephrogenic diabetes insipidus (HP:0009806)1.93768858
77Glycosuria (HP:0003076)1.93698258
78Abnormality of urine glucose concentration (HP:0011016)1.93698258
79Chronic hepatic failure (HP:0100626)1.93672404
80Exercise intolerance (HP:0003546)1.89732275
81Neoplasm of the adrenal cortex (HP:0100641)1.89478989
82Severe visual impairment (HP:0001141)1.88160685
83Male pseudohermaphroditism (HP:0000037)1.87919251
84Hypomagnesemia (HP:0002917)1.86824210
85Stomatitis (HP:0010280)1.85035438
86Leukodystrophy (HP:0002415)1.84713131
87Growth hormone deficiency (HP:0000824)1.84485346
88Abolished electroretinogram (ERG) (HP:0000550)1.83381605
89Congenital, generalized hypertrichosis (HP:0004540)1.82828820
90Abnormal biliary tract physiology (HP:0012439)1.82452746
91Bile duct proliferation (HP:0001408)1.82452746
92Type II lissencephaly (HP:0007260)1.81290584
93Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81180757
94Methylmalonic acidemia (HP:0002912)1.79733774
95Absent septum pellucidum (HP:0001331)1.79373910
96Triphalangeal thumb (HP:0001199)1.79268459
97IgG deficiency (HP:0004315)1.79059398
98Ketosis (HP:0001946)1.77397223
99Muscle fiber atrophy (HP:0100295)1.76690139
100Hyperphosphaturia (HP:0003109)1.76119117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.09616214
2VRK23.81849222
3STK163.73377827
4ZAK3.07062382
5CDK192.64617658
6BMPR1B2.36073947
7WNK42.30643886
8NUAK12.30309288
9TIE12.24901747
10VRK12.21498338
11GRK11.99178324
12WNK31.98414725
13LIMK11.88391303
14DYRK21.83065107
15ADRBK21.77598022
16MAP4K21.76172692
17TXK1.56761949
18PLK31.56447072
19KDR1.52020965
20CDC71.48271689
21TLK11.45486869
22FRK1.42045863
23NME21.38108403
24PASK1.37073355
25PINK11.36605085
26GRK61.31869640
27BUB11.30325005
28LRRK21.30271961
29TAOK31.13243768
30PDK21.06778595
31TAF11.04825471
32MAP4K11.01106618
33MAPK131.00030420
34NME10.97917567
35PLK40.93288078
36STK390.93186055
37PIK3CA0.93061515
38PLK20.92811402
39MST40.92598653
40TGFBR10.91489664
41EPHB20.88523589
42MUSK0.84985281
43PRKCQ0.82865001
44NEK10.82372118
45ACVR1B0.78669684
46ADRBK10.74380313
47EPHA40.74239249
48TEC0.73099260
49CHEK20.71584519
50OXSR10.71029216
51INSRR0.69712896
52CAMK10.66932110
53BRSK10.66695436
54ITK0.66667993
55PLK10.66163405
56TTK0.64407396
57PRKCG0.63141803
58CSNK1G30.56934224
59AURKB0.54621883
60RPS6KA50.53556762
61ATR0.52365679
62DAPK30.51335592
63CDK30.51181595
64BRSK20.50533487
65TRIM280.50411068
66CSNK2A10.49708517
67FLT30.49512821
68TNIK0.49510465
69SYK0.48398638
70PRKCE0.46589804
71PRKCI0.46473795
72MKNK10.46249065
73CSNK1G20.46225879
74ABL20.45592795
75CSNK2A20.45210060
76MAPKAPK50.45149949
77WEE10.44107193
78TESK20.43380009
79GRK50.42288289
80IKBKB0.42151726
81PHKG20.41501194
82PHKG10.41501194
83MAPKAPK30.40615572
84PRKACA0.40332013
85CSF1R0.38533553
86CDK80.37597542
87NEK20.36824459
88CSNK1G10.36428653
89MAP3K40.36389228
90BTK0.36192154
91STK40.35176787
92TNK20.34131494
93CSNK1A1L0.32526329
94STK110.32083434
95PRKCA0.31581213
96OBSCN0.31284725
97MKNK20.31153466
98CAMKK20.29325054
99PRKD30.29132331
100MATK0.29065107

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.87088657
2Oxidative phosphorylation_Homo sapiens_hsa001904.16717347
3Parkinsons disease_Homo sapiens_hsa050123.44158030
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.24951129
5Proteasome_Homo sapiens_hsa030502.75992880
6RNA polymerase_Homo sapiens_hsa030202.72779547
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.47830665
8Huntingtons disease_Homo sapiens_hsa050162.45900663
9Alzheimers disease_Homo sapiens_hsa050102.27231369
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11201645
11Homologous recombination_Homo sapiens_hsa034402.01802119
12Cardiac muscle contraction_Homo sapiens_hsa042601.90016696
13Protein export_Homo sapiens_hsa030601.89796475
14Propanoate metabolism_Homo sapiens_hsa006401.85164247
15RNA degradation_Homo sapiens_hsa030181.84739860
16Pyrimidine metabolism_Homo sapiens_hsa002401.68088627
17Primary immunodeficiency_Homo sapiens_hsa053401.62717861
18Linoleic acid metabolism_Homo sapiens_hsa005911.59031075
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.55138270
20Fanconi anemia pathway_Homo sapiens_hsa034601.54575518
21Maturity onset diabetes of the young_Homo sapiens_hsa049501.44874077
22Phototransduction_Homo sapiens_hsa047441.43695052
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.43297586
24Purine metabolism_Homo sapiens_hsa002301.42284650
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.37370595
26Sulfur metabolism_Homo sapiens_hsa009201.35892716
27DNA replication_Homo sapiens_hsa030301.32335255
28Mismatch repair_Homo sapiens_hsa034301.28799455
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26249125
30Basal transcription factors_Homo sapiens_hsa030221.24093042
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19023691
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.16638209
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11673247
34Peroxisome_Homo sapiens_hsa041461.11081270
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.05548841
36Nucleotide excision repair_Homo sapiens_hsa034201.04880037
37Tryptophan metabolism_Homo sapiens_hsa003801.03715387
38Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00171224
39Asthma_Homo sapiens_hsa053100.99496591
40Sulfur relay system_Homo sapiens_hsa041220.97815883
41Nitrogen metabolism_Homo sapiens_hsa009100.96067637
42Metabolic pathways_Homo sapiens_hsa011000.93243704
43Allograft rejection_Homo sapiens_hsa053300.92052663
44Fat digestion and absorption_Homo sapiens_hsa049750.90965484
45Autoimmune thyroid disease_Homo sapiens_hsa053200.90002274
46Cysteine and methionine metabolism_Homo sapiens_hsa002700.89951465
47RNA transport_Homo sapiens_hsa030130.88866764
48Chemical carcinogenesis_Homo sapiens_hsa052040.87688137
49Arachidonic acid metabolism_Homo sapiens_hsa005900.85068327
50Type I diabetes mellitus_Homo sapiens_hsa049400.84809408
51Spliceosome_Homo sapiens_hsa030400.84526279
52Fatty acid elongation_Homo sapiens_hsa000620.80336471
53Base excision repair_Homo sapiens_hsa034100.79493852
54Retinol metabolism_Homo sapiens_hsa008300.79178246
55One carbon pool by folate_Homo sapiens_hsa006700.77893381
56Butanoate metabolism_Homo sapiens_hsa006500.74762469
57Intestinal immune network for IgA production_Homo sapiens_hsa046720.74749929
58Collecting duct acid secretion_Homo sapiens_hsa049660.74212472
59Glutathione metabolism_Homo sapiens_hsa004800.72137896
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72103851
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72056993
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71203221
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68588118
64beta-Alanine metabolism_Homo sapiens_hsa004100.67589106
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.67331617
66Ether lipid metabolism_Homo sapiens_hsa005650.63560021
67Caffeine metabolism_Homo sapiens_hsa002320.63349014
68Folate biosynthesis_Homo sapiens_hsa007900.59760258
69SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57211171
70Selenocompound metabolism_Homo sapiens_hsa004500.57150576
71Drug metabolism - other enzymes_Homo sapiens_hsa009830.56829238
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55327459
73Graft-versus-host disease_Homo sapiens_hsa053320.54995655
74Rheumatoid arthritis_Homo sapiens_hsa053230.54662401
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52658336
76N-Glycan biosynthesis_Homo sapiens_hsa005100.51693853
77Tyrosine metabolism_Homo sapiens_hsa003500.51499572
78Fatty acid degradation_Homo sapiens_hsa000710.49889887
79Non-homologous end-joining_Homo sapiens_hsa034500.49753122
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.47418983
81Vitamin B6 metabolism_Homo sapiens_hsa007500.46394705
82Vitamin digestion and absorption_Homo sapiens_hsa049770.45763303
83Fatty acid metabolism_Homo sapiens_hsa012120.45674571
84Pyruvate metabolism_Homo sapiens_hsa006200.44970084
85Olfactory transduction_Homo sapiens_hsa047400.44371765
86Regulation of autophagy_Homo sapiens_hsa041400.42952580
87Nicotine addiction_Homo sapiens_hsa050330.39803105
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37050056
89Hedgehog signaling pathway_Homo sapiens_hsa043400.36997646
90Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34768649
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32587541
92Glycerolipid metabolism_Homo sapiens_hsa005610.32271450
93Basal cell carcinoma_Homo sapiens_hsa052170.30162751
94Mineral absorption_Homo sapiens_hsa049780.29005601
95Insulin secretion_Homo sapiens_hsa049110.28004493
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.25799789
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24407792
98Ovarian steroidogenesis_Homo sapiens_hsa049130.20568118
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18448237
100Arginine and proline metabolism_Homo sapiens_hsa003300.17508000

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