RPL7AP57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)9.99800905
2viral transcription (GO:0019083)8.09667547
3translational termination (GO:0006415)7.75569906
4ribosomal small subunit assembly (GO:0000028)7.29334660
5ribosomal small subunit biogenesis (GO:0042274)7.16220127
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.37359210
7cotranslational protein targeting to membrane (GO:0006613)6.28160243
8translational elongation (GO:0006414)6.27901088
9oxygen transport (GO:0015671)6.18873287
10protein targeting to ER (GO:0045047)6.18405899
11viral life cycle (GO:0019058)5.95774579
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.93702226
13cellular protein complex disassembly (GO:0043624)5.92099262
14protein localization to endoplasmic reticulum (GO:0070972)5.85910022
15nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.69102836
16protein complex disassembly (GO:0043241)5.25942932
17response to dietary excess (GO:0002021)5.20866466
18macromolecular complex disassembly (GO:0032984)5.10216833
19gas transport (GO:0015669)5.04377345
20ATP synthesis coupled proton transport (GO:0015986)4.99283390
21energy coupled proton transport, down electrochemical gradient (GO:0015985)4.99283390
22positive regulation of vesicle fusion (GO:0031340)4.92945310
23translational initiation (GO:0006413)4.92915299
24chaperone-mediated protein transport (GO:0072321)4.82017129
25cell proliferation in forebrain (GO:0021846)4.64045246
26protein targeting to membrane (GO:0006612)4.25960709
27Sertoli cell development (GO:0060009)4.20467095
28rRNA catabolic process (GO:0016075)4.15637995
29nonmotile primary cilium assembly (GO:0035058)4.12436754
30negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)4.10231401
31hypothalamus development (GO:0021854)4.09776097
32nuclear-transcribed mRNA catabolic process (GO:0000956)3.92144443
33epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.72521722
34mRNA catabolic process (GO:0006402)3.71462797
35cell wall macromolecule catabolic process (GO:0016998)3.71291684
36kinetochore organization (GO:0051383)3.62625508
37ribonucleoprotein complex biogenesis (GO:0022613)3.59590945
38short-chain fatty acid metabolic process (GO:0046459)3.59449555
39ribosomal large subunit biogenesis (GO:0042273)3.56801155
40translation (GO:0006412)3.56282583
41regulation of meiosis I (GO:0060631)3.48587441
42centriole replication (GO:0007099)3.46775259
43positive regulation of prostaglandin secretion (GO:0032308)3.45455475
44myoblast migration (GO:0051451)3.44201032
45exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.41134800
46RNA catabolic process (GO:0006401)3.35754649
47nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.29951647
48kinetochore assembly (GO:0051382)3.27546428
49cellular component biogenesis (GO:0044085)3.25349573
50regulation of cilium movement (GO:0003352)3.23752241
51negative regulation of DNA-templated transcription, elongation (GO:0032785)3.21545159
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.16455507
53positive regulation of megakaryocyte differentiation (GO:0045654)3.16122673
54cell wall macromolecule metabolic process (GO:0044036)3.12746994
55regulation of non-canonical Wnt signaling pathway (GO:2000050)3.11861582
56positive regulation of sodium ion transmembrane transport (GO:1902307)3.10827565
57ubiquinone biosynthetic process (GO:0006744)3.10076436
58positive regulation of icosanoid secretion (GO:0032305)3.08867521
59establishment of protein localization to membrane (GO:0090150)3.06836599
60regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.05165529
61pattern specification involved in kidney development (GO:0061004)3.04480668
62ribonucleoprotein complex disassembly (GO:0032988)3.04204946
63positive regulation of fatty acid transport (GO:2000193)3.03904153
64organelle disassembly (GO:1903008)3.00939588
65ubiquinone metabolic process (GO:0006743)2.97434993
66axonemal dynein complex assembly (GO:0070286)2.93159977
67ATP biosynthetic process (GO:0006754)2.90439494
68mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90024428
69cellular response to ATP (GO:0071318)2.89103015
70S-adenosylmethionine metabolic process (GO:0046500)2.87767484
71kidney morphogenesis (GO:0060993)2.86850733
72response to food (GO:0032094)2.83331910
73negative regulation of telomere maintenance (GO:0032205)2.82807458
74protein neddylation (GO:0045116)2.81752954
75negative regulation of organelle assembly (GO:1902116)2.79709633
76negative regulation of appetite (GO:0032099)2.76895188
77negative regulation of response to food (GO:0032096)2.76895188
78replication fork processing (GO:0031297)2.76634940
79neuron fate determination (GO:0048664)2.76509108
80response to misfolded protein (GO:0051788)2.75623511
81establishment of protein localization to mitochondrial membrane (GO:0090151)2.73532151
82regulation of prostaglandin secretion (GO:0032306)2.73229606
83protein complex biogenesis (GO:0070271)2.71804663
84behavioral response to nicotine (GO:0035095)2.69849922
85DNA deamination (GO:0045006)2.68344023
86ncRNA catabolic process (GO:0034661)2.68276016
87protein targeting (GO:0006605)2.68006868
88positive regulation of Notch signaling pathway (GO:0045747)2.67415996
89L-serine metabolic process (GO:0006563)2.67136392
90nucleotide transmembrane transport (GO:1901679)2.66346201
91resolution of meiotic recombination intermediates (GO:0000712)2.64289359
92establishment of protein localization to organelle (GO:0072594)2.63319144
93proline transport (GO:0015824)2.62015781
94protein-cofactor linkage (GO:0018065)2.61655240
95respiratory electron transport chain (GO:0022904)2.59134684
96electron transport chain (GO:0022900)2.59072250
97melanosome transport (GO:0032402)2.57822033
98tongue development (GO:0043586)2.57401848
99autophagic vacuole fusion (GO:0000046)2.56851140
100purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.55643726

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human3.61411213
2EZH2_22144423_ChIP-Seq_EOC_Human3.41421903
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.08152950
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.75932128
5GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45539453
6CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.42966606
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.34035778
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.27414096
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.18518541
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14790180
11ZNF274_21170338_ChIP-Seq_K562_Hela2.12878643
12IRF1_19129219_ChIP-ChIP_H3396_Human2.07772541
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.05938817
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.99514642
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99039769
16TTF2_22483619_ChIP-Seq_HELA_Human1.96904987
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90161931
18SRY_22984422_ChIP-ChIP_TESTIS_Rat1.86059189
19VDR_22108803_ChIP-Seq_LS180_Human1.81580737
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81330213
21GATA3_21878914_ChIP-Seq_MCF-7_Human1.80935131
22EST1_17652178_ChIP-ChIP_JURKAT_Human1.80396412
23MYC_19079543_ChIP-ChIP_MESCs_Mouse1.76364110
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.73108116
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71903961
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.66422519
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.63491946
28KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.61093945
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60392469
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.58363367
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.56317569
32CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.55380498
33CBX2_27304074_Chip-Seq_ESCs_Mouse1.49899717
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.48586394
35ERA_21632823_ChIP-Seq_H3396_Human1.46484641
36RNF2_27304074_Chip-Seq_NSC_Mouse1.44300424
37POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41945593
38SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38849930
39CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37996595
40VDR_23849224_ChIP-Seq_CD4+_Human1.36116854
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35892246
42GABP_19822575_ChIP-Seq_HepG2_Human1.35887520
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34915435
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.33078309
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.32555239
46EWS_26573619_Chip-Seq_HEK293_Human1.31206394
47ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30534340
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.27799979
49XRN2_22483619_ChIP-Seq_HELA_Human1.27580027
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26941202
51CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.26704671
52FUS_26573619_Chip-Seq_HEK293_Human1.26071726
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.26023378
54CTCF_20526341_ChIP-Seq_ESCs_Human1.25084876
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24746761
56TP53_22573176_ChIP-Seq_HFKS_Human1.23590111
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.23562769
58GATA1_26923725_Chip-Seq_HPCs_Mouse1.20988441
59MYC_18940864_ChIP-ChIP_HL60_Human1.18830011
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.16180141
61CTCF_27219007_Chip-Seq_Bcells_Human1.15617162
62GATA3_21867929_ChIP-Seq_TH1_Mouse1.14603991
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.13191073
64FOXP3_21729870_ChIP-Seq_TREG_Human1.10959602
65NANOG_20526341_ChIP-Seq_ESCs_Human1.10878282
66MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.09757703
67FOXP1_21924763_ChIP-Seq_HESCs_Human1.09204342
68EED_16625203_ChIP-ChIP_MESCs_Mouse1.09063351
69TP53_20018659_ChIP-ChIP_R1E_Mouse1.08785417
70NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08665177
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08120835
72RNF2_27304074_Chip-Seq_ESCs_Mouse1.05144647
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04924679
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.04753584
75SOX2_16153702_ChIP-ChIP_HESCs_Human1.02135850
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.00037958
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.99091865
78SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98930996
79CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98698081
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.97781147
81EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.97648084
82E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97589915
83P53_21459846_ChIP-Seq_SAOS-2_Human0.97497428
84EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96936092
85SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96337471
86YY1_22570637_ChIP-Seq_MALME-3M_Human0.95259135
87TAF2_19829295_ChIP-Seq_ESCs_Human0.93687865
88BCL6_27268052_Chip-Seq_Bcells_Human0.92959324
89BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92785534
90SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92614762
91RNF2_18974828_ChIP-Seq_MESCs_Mouse0.92389785
92EZH2_18974828_ChIP-Seq_MESCs_Mouse0.92389785
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92377025
94RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.91039020
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90634780
96MYC_19829295_ChIP-Seq_ESCs_Human0.90501373
97E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90369249
98TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89530186
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89314842
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.88887578

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation6.05675682
2MP0006292_abnormal_olfactory_placode4.43111104
3MP0004885_abnormal_endolymph4.06517848
4MP0003878_abnormal_ear_physiology3.11458603
5MP0005377_hearing/vestibular/ear_phenot3.11458603
6MP0001348_abnormal_lacrimal_gland2.91269912
7MP0010030_abnormal_orbit_morphology2.82922172
8MP0003122_maternal_imprinting2.66291376
9MP0004147_increased_porphyrin_level2.65604306
10MP0001293_anophthalmia2.60488801
11MP0003136_yellow_coat_color2.51687673
12MP0000372_irregular_coat_pigmentation2.45815971
13MP0000566_synostosis2.22388004
14MP0008789_abnormal_olfactory_epithelium2.17877129
15MP0004142_abnormal_muscle_tone2.15829598
16MP0008877_abnormal_DNA_methylation2.08804509
17MP0000631_abnormal_neuroendocrine_gland2.05616363
18MP0001188_hyperpigmentation1.91748752
19MP0003011_delayed_dark_adaptation1.89447515
20MP0000049_abnormal_middle_ear1.74115629
21MP0005499_abnormal_olfactory_system1.72963099
22MP0005394_taste/olfaction_phenotype1.72963099
23MP0000778_abnormal_nervous_system1.71068644
24MP0005075_abnormal_melanosome_morpholog1.62107856
25MP0009046_muscle_twitch1.60134720
26MP0002095_abnormal_skin_pigmentation1.59842177
27MP0006276_abnormal_autonomic_nervous1.58203954
28MP0002938_white_spotting1.52387893
29MP0002736_abnormal_nociception_after1.47907192
30MP0002234_abnormal_pharynx_morphology1.42794228
31MP0005174_abnormal_tail_pigmentation1.41686363
32MP0003121_genomic_imprinting1.40706425
33MP0008872_abnormal_physiological_respon1.38033507
34MP0005423_abnormal_somatic_nervous1.37974049
35MP0003646_muscle_fatigue1.34638759
36MP0001968_abnormal_touch/_nociception1.34419774
37MP0003186_abnormal_redox_activity1.32411111
38MP0000026_abnormal_inner_ear1.32269512
39MP0005408_hypopigmentation1.29788460
40MP0001485_abnormal_pinna_reflex1.23653052
41MP0003786_premature_aging1.21528312
42MP0008058_abnormal_DNA_repair1.18750105
43MP0001529_abnormal_vocalization1.18469308
44MP0001905_abnormal_dopamine_level1.18445033
45MP0005551_abnormal_eye_electrophysiolog1.17817583
46MP0002102_abnormal_ear_morphology1.15881339
47MP0002163_abnormal_gland_morphology1.12877962
48MP0001963_abnormal_hearing_physiology1.09723543
49MP0003937_abnormal_limbs/digits/tail_de1.08663389
50MP0004043_abnormal_pH_regulation1.06904147
51MP0002249_abnormal_larynx_morphology1.06819890
52MP0002272_abnormal_nervous_system1.04217317
53MP0002210_abnormal_sex_determination1.02792253
54MP0002653_abnormal_ependyma_morphology1.02202404
55MP0000427_abnormal_hair_cycle1.02020184
56MP0005379_endocrine/exocrine_gland_phen1.01296576
57MP0001440_abnormal_grooming_behavior0.99602900
58MP0001286_abnormal_eye_development0.98720134
59MP0003567_abnormal_fetal_cardiomyocyte0.98371059
60MP0005391_vision/eye_phenotype0.96979365
61MP0005253_abnormal_eye_physiology0.96605519
62MP0004133_heterotaxia0.95073272
63MP0000569_abnormal_digit_pigmentation0.94840958
64MP0005195_abnormal_posterior_eye0.94708327
65MP0002697_abnormal_eye_size0.92278988
66MP0003942_abnormal_urinary_system0.90235691
67MP0003879_abnormal_hair_cell0.89406488
68MP0002734_abnormal_mechanical_nocicepti0.88479383
69MP0001502_abnormal_circadian_rhythm0.84302821
70MP0009053_abnormal_anal_canal0.84003916
71MP0002557_abnormal_social/conspecific_i0.83939549
72MP0002233_abnormal_nose_morphology0.83927903
73MP0000015_abnormal_ear_pigmentation0.83559380
74MP0002092_abnormal_eye_morphology0.82607053
75MP0003936_abnormal_reproductive_system0.82350010
76MP0003698_abnormal_male_reproductive0.81670645
77MP0002638_abnormal_pupillary_reflex0.81648887
78MP0008775_abnormal_heart_ventricle0.81107919
79MP0001486_abnormal_startle_reflex0.80865852
80MP0001929_abnormal_gametogenesis0.80063226
81MP0008007_abnormal_cellular_replicative0.79681707
82MP0000955_abnormal_spinal_cord0.79605642
83MP0002733_abnormal_thermal_nociception0.77989645
84MP0003755_abnormal_palate_morphology0.77402459
85MP0000653_abnormal_sex_gland0.75732928
86MP0002752_abnormal_somatic_nervous0.75635738
87MP0009745_abnormal_behavioral_response0.75282852
88MP0000647_abnormal_sebaceous_gland0.73302512
89MP0006072_abnormal_retinal_apoptosis0.73209872
90MP0001145_abnormal_male_reproductive0.73089832
91MP0004130_abnormal_muscle_cell0.71832589
92MP0003787_abnormal_imprinting0.71547844
93MP0001119_abnormal_female_reproductive0.69315099
94MP0001970_abnormal_pain_threshold0.68751656
95MP0005410_abnormal_fertilization0.68668238
96MP0001984_abnormal_olfaction0.67053476
97MP0001986_abnormal_taste_sensitivity0.65994271
98MP0009250_abnormal_appendicular_skeleto0.61157585
99MP0002116_abnormal_craniofacial_bone0.60610300
100MP0006035_abnormal_mitochondrial_morpho0.60565730

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)6.74594261
2Abnormal hemoglobin (HP:0011902)6.47151470
3Pallor (HP:0000980)4.48287757
4Abnormality of cells of the erythroid lineage (HP:0012130)4.38740570
5Septo-optic dysplasia (HP:0100842)4.23731553
6Abnormality of the heme biosynthetic pathway (HP:0010472)4.03736111
7Macrocytic anemia (HP:0001972)3.59790374
8Pancreatic fibrosis (HP:0100732)3.47483576
9Aplasia/Hypoplasia of the sacrum (HP:0008517)3.43140734
10Rib fusion (HP:0000902)3.41328096
11Medial flaring of the eyebrow (HP:0010747)3.14971162
12Pancreatic cysts (HP:0001737)3.10885900
13Stenosis of the external auditory canal (HP:0000402)3.09760927
14Gait imbalance (HP:0002141)3.01542973
15Abnormality of the labia minora (HP:0012880)2.96714613
16Congenital primary aphakia (HP:0007707)2.94117022
17Tubular atrophy (HP:0000092)2.91154078
18Supernumerary spleens (HP:0009799)2.90005165
19Acute encephalopathy (HP:0006846)2.86250076
20Abnormality of midbrain morphology (HP:0002418)2.83740016
21Molar tooth sign on MRI (HP:0002419)2.83740016
22Absent septum pellucidum (HP:0001331)2.83561735
23Tubulointerstitial fibrosis (HP:0005576)2.83169354
24Acute necrotizing encephalopathy (HP:0006965)2.78033043
25Lipid accumulation in hepatocytes (HP:0006561)2.74723552
26Anophthalmia (HP:0000528)2.72549142
27Decreased central vision (HP:0007663)2.71024558
28Nephrogenic diabetes insipidus (HP:0009806)2.70730755
29Ectopic kidney (HP:0000086)2.54753754
30Chronic hepatic failure (HP:0100626)2.47895341
31Abnormal number of erythroid precursors (HP:0012131)2.47571728
32Bifid tongue (HP:0010297)2.47281809
33Absent thumb (HP:0009777)2.47185948
34Abnormal mitochondria in muscle tissue (HP:0008316)2.47152711
35Abnormality of the renal cortex (HP:0011035)2.46428221
36Abnormal drinking behavior (HP:0030082)2.46426134
37Polydipsia (HP:0001959)2.46426134
38True hermaphroditism (HP:0010459)2.45710802
39Abnormality of DNA repair (HP:0003254)2.45332689
40Abnormality of reticulocytes (HP:0004312)2.44265956
41Optic nerve hypoplasia (HP:0000609)2.38048125
42Growth hormone deficiency (HP:0000824)2.36682163
43Maternal diabetes (HP:0009800)2.35204964
44Mitochondrial inheritance (HP:0001427)2.34246222
45Vaginal atresia (HP:0000148)2.33482779
46Renal dysplasia (HP:0000110)2.32427107
47Cystic liver disease (HP:0006706)2.31544748
48Abnormal biliary tract physiology (HP:0012439)2.31359049
49Bile duct proliferation (HP:0001408)2.31359049
50Poor coordination (HP:0002370)2.29661766
51Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.28739961
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.23895052
53Genital tract atresia (HP:0001827)2.23089308
54Polyphagia (HP:0002591)2.22028463
55Sclerocornea (HP:0000647)2.21881615
56Type II lissencephaly (HP:0007260)2.21615445
57Adrenal hypoplasia (HP:0000835)2.21062661
58Nephronophthisis (HP:0000090)2.20297048
59Submucous cleft hard palate (HP:0000176)2.17491629
60Tubulointerstitial abnormality (HP:0001969)2.17456159
61Abnormality of cochlea (HP:0000375)2.17221200
62Occipital encephalocele (HP:0002085)2.14834752
63Increased hepatocellular lipid droplets (HP:0006565)2.14511645
64Abnormality of the renal medulla (HP:0100957)2.13060441
65Asplenia (HP:0001746)2.12637288
66Increased CSF lactate (HP:0002490)2.12601199
67Cortical visual impairment (HP:0100704)2.10413371
68Postaxial foot polydactyly (HP:0001830)2.07501546
69J-shaped sella turcica (HP:0002680)2.06573742
70Abnormality of the septum pellucidum (HP:0007375)2.04949738
71Depressed nasal ridge (HP:0000457)2.04116847
72Anencephaly (HP:0002323)2.02229324
73Progressive macrocephaly (HP:0004481)2.01028502
74Triphalangeal thumb (HP:0001199)1.99740639
75Abnormal ciliary motility (HP:0012262)1.98241073
76Multicystic kidney dysplasia (HP:0000003)1.98117723
77Postaxial hand polydactyly (HP:0001162)1.97328578
78Male pseudohermaphroditism (HP:0000037)1.96810880
79Increased muscle lipid content (HP:0009058)1.96276143
80Aplasia/Hypoplasia of the uvula (HP:0010293)1.95598970
81Pendular nystagmus (HP:0012043)1.91906093
82Vitreoretinal degeneration (HP:0000655)1.90730693
83Congenital hepatic fibrosis (HP:0002612)1.89036106
84Duplication of thumb phalanx (HP:0009942)1.84427314
85Increased intramyocellular lipid droplets (HP:0012240)1.84196125
86Retinal dysplasia (HP:0007973)1.78401854
8711 pairs of ribs (HP:0000878)1.75796578
88Hyperthyroidism (HP:0000836)1.74917513
89Poor suck (HP:0002033)1.74588157
90Polyuria (HP:0000103)1.73939130
91Abnormal respiratory motile cilium physiology (HP:0012261)1.73399394
92Abnormality of the phalanges of the hallux (HP:0010057)1.70945569
93Ulnar claw (HP:0001178)1.67765401
94Severe visual impairment (HP:0001141)1.67395301
95Missing ribs (HP:0000921)1.65657554
96Hepatocellular necrosis (HP:0001404)1.65216471
97Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.64693228
98Oligodactyly (HP:0012165)1.64560077
99Broad foot (HP:0001769)1.62760800
100Aganglionic megacolon (HP:0002251)1.62606725

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.26170186
2BRAF3.22147031
3NEK13.11756571
4WNK43.07993799
5DYRK22.92100580
6MAP4K22.66549364
7EPHB22.57552211
8PLK42.51568762
9PIK3CA2.34034970
10MAP2K62.08970006
11STK162.03019547
12ADRBK21.90520929
13SGK2231.88649108
14SGK4941.88649108
15PLK21.83966430
16CDK191.72061074
17BCKDK1.64972086
18PNCK1.63992514
19MAP3K111.59064804
20LRRK21.55570428
21GRK11.53383055
22EPHA41.45490923
23PASK1.37336497
24WEE11.37228466
25AURKA1.36976385
26PINK11.36057143
27AURKB1.30512073
28ZAK1.29423226
29CAMK11.19352264
30CASK1.10160608
31BMX1.10009211
32PRKCI1.06915381
33CDC71.05028136
34RPS6KA61.03087896
35DAPK31.02217200
36PHKG20.98452566
37PHKG10.98452566
38UHMK10.95264426
39NEK20.93439443
40WNK10.90588564
41RPS6KC10.89610853
42RPS6KL10.89610853
43SGK20.89577507
44RPS6KA40.86964512
45STK110.86792628
46INSRR0.85970622
47DYRK1B0.84286549
48PLK30.82264091
49BRSK10.81779271
50TGFBR10.78342996
51PLK10.78142308
52SGK10.77864386
53PIM10.70771725
54ERBB20.67890401
55MAP3K40.67630612
56PRKCG0.66759732
57ADRBK10.65745268
58MOS0.65666978
59PRKACA0.64861483
60CHEK20.63794495
61MAPK130.63445314
62PRKCQ0.62974853
63MUSK0.62434671
64WNK30.61324857
65CAMK1G0.55723931
66VRK20.55455470
67EIF2AK10.55303944
68BMPR1B0.55278289
69CSNK2A20.54992600
70CAMK2D0.54571901
71TIE10.53683504
72PIM20.52951494
73MAPK150.52891443
74CAMK40.50930586
75CHEK10.50608797
76OBSCN0.47263539
77MAP2K70.47234399
78PRKCZ0.46225027
79TYRO30.45788310
80RPS6KA50.45438840
81STK390.44018696
82DAPK20.43176708
83TNK20.42770476
84PDK20.42703134
85OXSR10.42283329
86CAMK2A0.42159196
87PAK60.38640904
88CDK30.36591023
89CSNK1A10.36518178
90RPS6KA10.35932709
91PRKACB0.35895166
92NTRK20.34740534
93AKT10.34666297
94ATR0.32932096
95MARK30.32870625
96PRKCA0.32034088
97CSNK2A10.31427458
98FRK0.31028169
99PRKDC0.30757263
100AKT20.28844925

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030107.28432343
2Oxidative phosphorylation_Homo sapiens_hsa001903.48925741
3Sulfur relay system_Homo sapiens_hsa041223.04129134
4Parkinsons disease_Homo sapiens_hsa050123.00167005
5Cardiac muscle contraction_Homo sapiens_hsa042602.36306611
6Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.35899741
7RNA polymerase_Homo sapiens_hsa030202.26528751
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.19538842
9Huntingtons disease_Homo sapiens_hsa050162.19343341
10Nitrogen metabolism_Homo sapiens_hsa009102.12053411
11Homologous recombination_Homo sapiens_hsa034402.08660321
12Basal transcription factors_Homo sapiens_hsa030222.08373178
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.06999005
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04970169
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95747928
16Linoleic acid metabolism_Homo sapiens_hsa005911.86477445
17Fanconi anemia pathway_Homo sapiens_hsa034601.86270253
18RNA degradation_Homo sapiens_hsa030181.83880473
19Alzheimers disease_Homo sapiens_hsa050101.79448574
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.79298955
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.63518030
22One carbon pool by folate_Homo sapiens_hsa006701.57731856
23Proteasome_Homo sapiens_hsa030501.49886733
24Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.45903472
25Protein export_Homo sapiens_hsa030601.40400056
26Butanoate metabolism_Homo sapiens_hsa006501.36045040
27Fat digestion and absorption_Homo sapiens_hsa049751.32896875
28Propanoate metabolism_Homo sapiens_hsa006401.29014914
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25165272
30Phototransduction_Homo sapiens_hsa047441.21416912
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.18677609
32Fatty acid biosynthesis_Homo sapiens_hsa000611.12272138
33Olfactory transduction_Homo sapiens_hsa047401.12188131
34Steroid biosynthesis_Homo sapiens_hsa001001.10792161
35Pyruvate metabolism_Homo sapiens_hsa006200.99079817
36Hedgehog signaling pathway_Homo sapiens_hsa043400.97454408
37Ether lipid metabolism_Homo sapiens_hsa005650.94421889
38Carbohydrate digestion and absorption_Homo sapiens_hsa049730.92700516
39Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90068985
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88951317
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88132411
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.88096364
43Pyrimidine metabolism_Homo sapiens_hsa002400.87512361
44Dorso-ventral axis formation_Homo sapiens_hsa043200.83866876
45Basal cell carcinoma_Homo sapiens_hsa052170.83484355
46Chemical carcinogenesis_Homo sapiens_hsa052040.81974115
47Retinol metabolism_Homo sapiens_hsa008300.80862787
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80610439
49Nucleotide excision repair_Homo sapiens_hsa034200.79807384
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79309900
51Fatty acid degradation_Homo sapiens_hsa000710.74269499
52Arachidonic acid metabolism_Homo sapiens_hsa005900.73668048
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73512304
54Notch signaling pathway_Homo sapiens_hsa043300.71236471
55Tryptophan metabolism_Homo sapiens_hsa003800.69912547
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66897283
57Peroxisome_Homo sapiens_hsa041460.66416847
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65624170
59RNA transport_Homo sapiens_hsa030130.64129766
60Steroid hormone biosynthesis_Homo sapiens_hsa001400.63552117
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63432068
62Metabolic pathways_Homo sapiens_hsa011000.62103105
63Protein digestion and absorption_Homo sapiens_hsa049740.60964926
64Mismatch repair_Homo sapiens_hsa034300.60418914
65Fatty acid metabolism_Homo sapiens_hsa012120.59389133
66Purine metabolism_Homo sapiens_hsa002300.57927774
67Insulin secretion_Homo sapiens_hsa049110.56311618
68Mineral absorption_Homo sapiens_hsa049780.56155417
69Tyrosine metabolism_Homo sapiens_hsa003500.56031245
70Caffeine metabolism_Homo sapiens_hsa002320.55188694
71Folate biosynthesis_Homo sapiens_hsa007900.53910926
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.53727786
73DNA replication_Homo sapiens_hsa030300.50292402
74Non-homologous end-joining_Homo sapiens_hsa034500.50222295
75Phenylalanine metabolism_Homo sapiens_hsa003600.49469231
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45239165
77Lysine degradation_Homo sapiens_hsa003100.45136074
78beta-Alanine metabolism_Homo sapiens_hsa004100.43412362
79Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.41995275
80Hippo signaling pathway_Homo sapiens_hsa043900.41230019
81Spliceosome_Homo sapiens_hsa030400.39800320
82Malaria_Homo sapiens_hsa051440.39364691
83Fatty acid elongation_Homo sapiens_hsa000620.37818365
84Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35347243
85Melanoma_Homo sapiens_hsa052180.34558480
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.34364868
87Biosynthesis of amino acids_Homo sapiens_hsa012300.30025960
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.29927505
89Starch and sucrose metabolism_Homo sapiens_hsa005000.28521703
90Bile secretion_Homo sapiens_hsa049760.27114170
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26827015
92Pancreatic secretion_Homo sapiens_hsa049720.25835989
93Arginine biosynthesis_Homo sapiens_hsa002200.23685702
94Thyroid hormone synthesis_Homo sapiens_hsa049180.23498282
95Vitamin digestion and absorption_Homo sapiens_hsa049770.22059250
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.22042622
97Carbon metabolism_Homo sapiens_hsa012000.21981540
98Glycerolipid metabolism_Homo sapiens_hsa005610.18964600
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18645189
100Nicotine addiction_Homo sapiens_hsa050330.17669504

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