ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	7.47213184
2	viral transcription (GO:0019083)	7.16003179
3	translational termination (GO:0006415)	6.87727908
4	neuron fate determination (GO:0048664)	6.73516117
5	ribosomal small subunit biogenesis (GO:0042274)	6.60346078
6	translational elongation (GO:0006414)	5.87276406
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.81647610
8	cotranslational protein targeting to membrane (GO:0006613)	5.70886559
9	cellular protein complex disassembly (GO:0043624)	5.66314172
10	maturation of SSU-rRNA (GO:0030490)	5.65632806
11	protein targeting to ER (GO:0045047)	5.64269230
12	microtubule depolymerization (GO:0007019)	5.59337542
13	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	5.36458622
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.36188863
15	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	5.28810260
16	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	5.25847377
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	5.25219071
18	protein localization to endoplasmic reticulum (GO:0070972)	5.25020653
19	ATP synthesis coupled proton transport (GO:0015986)	5.11580577
20	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.11580577
21	viral life cycle (GO:0019058)	5.08445622
22	protein complex disassembly (GO:0043241)	4.75778471
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.75601453
24	translational initiation (GO:0006413)	4.74142187
25	ribosomal large subunit biogenesis (GO:0042273)	4.63821177
26	regulation of hypersensitivity (GO:0002883)	4.57851206
27	negative regulation of DNA-templated transcription, elongation (GO:0032785)	4.54659643
28	macromolecular complex disassembly (GO:0032984)	4.52707590
29	purine deoxyribonucleotide catabolic process (GO:0009155)	4.49222498
30	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.44743059
31	chaperone-mediated protein transport (GO:0072321)	4.42671903
32	rRNA modification (GO:0000154)	4.22896687
33	hematopoietic stem cell proliferation (GO:0071425)	4.11699691
34	translation (GO:0006412)	3.95351710
35	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.88993794
36	positive regulation of respiratory burst (GO:0060267)	3.87475469
37	rRNA methylation (GO:0031167)	3.82668644
38	regulation of cellular extravasation (GO:0002691)	3.80650604
39	GTP biosynthetic process (GO:0006183)	3.80123601
40	protein targeting to membrane (GO:0006612)	3.72960749
41	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.67907421
42	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.64708987
43	protein neddylation (GO:0045116)	3.63311916
44	respiratory electron transport chain (GO:0022904)	3.61977397
45	protein complex biogenesis (GO:0070271)	3.59851698
46	electron transport chain (GO:0022900)	3.57255506
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.57189235
48	NADH dehydrogenase complex assembly (GO:0010257)	3.57189235
49	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.57189235
50	ribonucleoprotein complex biogenesis (GO:0022613)	3.56530224
51	mRNA catabolic process (GO:0006402)	3.49596384
52	positive regulation of mast cell degranulation (GO:0043306)	3.48019030
53	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.48019030
54	cellular component biogenesis (GO:0044085)	3.46368264
55	kinetochore assembly (GO:0051382)	3.43793464
56	hepatocyte differentiation (GO:0070365)	3.40750126
57	piRNA metabolic process (GO:0034587)	3.31810076
58	mitochondrial respiratory chain complex assembly (GO:0033108)	3.31016991
59	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.28688482
60	negative regulation of cell aging (GO:0090344)	3.27257920
61	deoxyribonucleotide catabolic process (GO:0009264)	3.25576378
62	UTP biosynthetic process (GO:0006228)	3.23158918
63	mitotic sister chromatid segregation (GO:0000070)	3.23010395
64	kinetochore organization (GO:0051383)	3.20464991
65	RNA catabolic process (GO:0006401)	3.18875749
66	water-soluble vitamin biosynthetic process (GO:0042364)	3.13450856
67	positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)	3.05071444
68	intracellular protein transmembrane import (GO:0044743)	3.04316496
69	DNA deamination (GO:0045006)	3.04175763
70	spinal cord association neuron differentiation (GO:0021527)	3.02615035
71	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.01756029
72	positive regulation of mast cell activation (GO:0033005)	3.00562303
73	behavioral response to nicotine (GO:0035095)	2.98248971
74	regulation of guanylate cyclase activity (GO:0031282)	2.97169207
75	respiratory chain complex IV assembly (GO:0008535)	2.95082314
76	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93628805
77	positive regulation of prostaglandin secretion (GO:0032308)	2.93594012
78	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.92624097
79	UTP metabolic process (GO:0046051)	2.91769498
80	deoxyribose phosphate catabolic process (GO:0046386)	2.91722405
81	CTP metabolic process (GO:0046036)	2.90317340
82	CTP biosynthetic process (GO:0006241)	2.90317340
83	resolution of meiotic recombination intermediates (GO:0000712)	2.88199319
84	cytochrome complex assembly (GO:0017004)	2.85233975
85	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.82991197
86	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.80514062
87	cellular response to interferon-beta (GO:0035458)	2.78520133
88	ATP biosynthetic process (GO:0006754)	2.77008375
89	male meiosis I (GO:0007141)	2.72393296
90	reciprocal meiotic recombination (GO:0007131)	2.71966149
91	reciprocal DNA recombination (GO:0035825)	2.71966149
92	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.69665995
93	rRNA processing (GO:0006364)	2.68562989
94	rRNA metabolic process (GO:0016072)	2.66835092
95	iron-sulfur cluster assembly (GO:0016226)	2.65330851
96	metallo-sulfur cluster assembly (GO:0031163)	2.65330851
97	microtubule polymerization or depolymerization (GO:0031109)	2.65202318
98	purine deoxyribonucleotide metabolic process (GO:0009151)	2.64664413
99	protein targeting to mitochondrion (GO:0006626)	2.62254355
100	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.60255489

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	7.01869980
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.24996313
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.11748955
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.33489727
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.32317828
6	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.28789414
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.10212862
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.04740646
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.95674712
10	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50686219
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.50387260
12	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.27394050
13	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.09392880
14	FOXP3_21729870_ChIP-Seq_TREG_Human	2.06440222
15	XRN2_22483619_ChIP-Seq_HELA_Human	2.05505197
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.02869623
17	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.01631121
18	TTF2_22483619_ChIP-Seq_HELA_Human	1.95507174
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93713486
20	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.93136567
21	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.87198753
22	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.83391098
23	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.81094956
24	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.80841679
25	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.79930553
26	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.75046433
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.70561156
28	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.68055324
29	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.67371842
30	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.65191653
31	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.64214955
32	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.63754496
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.61201307
34	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.50758504
35	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50351028
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.46005056
37	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.44172164
38	VDR_22108803_ChIP-Seq_LS180_Human	1.43270129
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.40113357
40	DCP1A_22483619_ChIP-Seq_HELA_Human	1.39753645
41	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.38118862
42	ELK1_19687146_ChIP-ChIP_HELA_Human	1.37291270
43	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.36063081
44	GABP_19822575_ChIP-Seq_HepG2_Human	1.34858595
45	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.34162916
46	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.33862453
47	CIITA_25753668_ChIP-Seq_RAJI_Human	1.31995707
48	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23648403
49	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.20942083
50	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.20237483
51	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.18448293
52	BCL6_27268052_Chip-Seq_Bcells_Human	1.18135336
53	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.18120802
54	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16891668
55	AR_20517297_ChIP-Seq_VCAP_Human	1.16639907
56	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.16329017
57	P53_21459846_ChIP-Seq_SAOS-2_Human	1.14794274
58	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.13613605
59	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.13234568
60	MYC_19829295_ChIP-Seq_ESCs_Human	1.11041021
61	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10572125
62	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10546967
63	ERA_21632823_ChIP-Seq_H3396_Human	1.10228243
64	CTCF_20526341_ChIP-Seq_ESCs_Human	1.09568960
65	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.08932364
66	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06578242
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05223140
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.03995788
69	STAT1_20625510_ChIP-Seq_HELA_Human	1.03597257
70	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.02462285
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01922761
72	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.00501705
73	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.99657998
74	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99344997
75	P300_27268052_Chip-Seq_Bcells_Human	0.99298034
76	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97656865
77	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97586662
78	FLI1_27457419_Chip-Seq_LIVER_Mouse	0.97415140
79	SA1_27219007_Chip-Seq_Bcells_Human	0.96655595
80	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.96622674
81	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96450791
82	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.96345249
83	THAP11_20581084_ChIP-Seq_MESCs_Mouse	0.95992577
84	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.94730806
85	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.93867080
86	EWS_26573619_Chip-Seq_HEK293_Human	0.93784412
87	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.93633891
88	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.93365828
89	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92703847
90	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.91747070
91	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.91633600
92	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.90610462
93	KDM5A_27292631_Chip-Seq_BREAST_Human	0.88164922
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.88026759
95	TET1_21451524_ChIP-Seq_MESCs_Mouse	0.86625349
96	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.86613629
97	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.86401735
98	ERG_20517297_ChIP-Seq_VCAP_Human	0.84854613
99	E2F1_20622854_ChIP-Seq_HELA_Human	0.84309474
100	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.83429514

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.19381658
2	MP0001873_stomach_inflammation	3.69103870
3	MP0005360_urolithiasis	3.51398233
4	MP0004142_abnormal_muscle_tone	2.83673664
5	MP0003693_abnormal_embryo_hatching	2.46476105
6	MP0002234_abnormal_pharynx_morphology	2.40410569
7	MP0004742_abnormal_vestibular_system	2.32026499
8	MP0002139_abnormal_hepatobiliary_system	2.29545377
9	MP0006292_abnormal_olfactory_placode	2.16599429
10	MP0006082_CNS_inflammation	2.10913114
11	MP0001986_abnormal_taste_sensitivity	2.08948585
12	MP0000566_synostosis	1.94300854
13	MP0004510_myositis	1.85761779
14	MP0000049_abnormal_middle_ear	1.84772228
15	MP0004147_increased_porphyrin_level	1.79885479
16	MP0005167_abnormal_blood-brain_barrier	1.79073592
17	MP0006276_abnormal_autonomic_nervous	1.76805054
18	MP0008877_abnormal_DNA_methylation	1.74255011
19	MP0008058_abnormal_DNA_repair	1.69160743
20	MP0002249_abnormal_larynx_morphology	1.67566397
21	MP0000685_abnormal_immune_system	1.64745474
22	MP0004019_abnormal_vitamin_homeostasis	1.63583987
23	MP0003718_maternal_effect	1.59887265
24	MP0010155_abnormal_intestine_physiology	1.59218525
25	MP0001663_abnormal_digestive_system	1.57134550
26	MP0000490_abnormal_crypts_of	1.54127327
27	MP0002876_abnormal_thyroid_physiology	1.54084583
28	MP0002938_white_spotting	1.48460261
29	MP0005671_abnormal_response_to	1.45285866
30	MP0002102_abnormal_ear_morphology	1.44486899
31	MP0002138_abnormal_hepatobiliary_system	1.42917084
32	MP0003806_abnormal_nucleotide_metabolis	1.41614085
33	MP0001485_abnormal_pinna_reflex	1.40835618
34	MP0001835_abnormal_antigen_presentation	1.39821698
35	MP0008775_abnormal_heart_ventricle	1.36616089
36	MP0008872_abnormal_physiological_respon	1.35129803
37	MP0001790_abnormal_immune_system	1.31534543
38	MP0005387_immune_system_phenotype	1.31534543
39	MP0000465_gastrointestinal_hemorrhage	1.31179015
40	MP0002837_dystrophic_cardiac_calcinosis	1.31109527
41	MP0005645_abnormal_hypothalamus_physiol	1.28236225
42	MP0003122_maternal_imprinting	1.26661836
43	MP0001666_abnormal_nutrient_absorption	1.25462398
44	MP0001293_anophthalmia	1.25042726
45	MP0004145_abnormal_muscle_electrophysio	1.24064353
46	MP0003866_abnormal_defecation	1.23209679
47	MP0001764_abnormal_homeostasis	1.22336438
48	MP0006036_abnormal_mitochondrial_physio	1.21551490
49	MP0003186_abnormal_redox_activity	1.21117221
50	MP0002277_abnormal_respiratory_mucosa	1.20722717
51	MP0005646_abnormal_pituitary_gland	1.17600531
52	MP0003011_delayed_dark_adaptation	1.17065269
53	MP0005365_abnormal_bile_salt	1.14585798
54	MP0006072_abnormal_retinal_apoptosis	1.11689305
55	MP0005381_digestive/alimentary_phenotyp	1.08554827
56	MP0002160_abnormal_reproductive_system	1.04105216
57	MP0001800_abnormal_humoral_immune	1.04027068
58	MP0005085_abnormal_gallbladder_physiolo	1.03347684
59	MP0001905_abnormal_dopamine_level	1.02395515
60	MP0002736_abnormal_nociception_after	1.00243274
61	MP0001440_abnormal_grooming_behavior	0.97350526
62	MP0002148_abnormal_hypersensitivity_rea	0.94687129
63	MP0002638_abnormal_pupillary_reflex	0.93540580
64	MP0005389_reproductive_system_phenotype	0.91692533
65	MP0005636_abnormal_mineral_homeostasis	0.90603714
66	MP0004885_abnormal_endolymph	0.88371846
67	MP0000516_abnormal_urinary_system	0.88001038
68	MP0005367_renal/urinary_system_phenotyp	0.88001038
69	MP0002653_abnormal_ependyma_morphology	0.86528172
70	MP0002735_abnormal_chemical_nociception	0.83376816
71	MP0001968_abnormal_touch/_nociception	0.83101720
72	MP0005423_abnormal_somatic_nervous	0.82719734
73	MP0005332_abnormal_amino_acid	0.82358205
74	MP0005551_abnormal_eye_electrophysiolog	0.80588260
75	MP0005166_decreased_susceptibility_to	0.80411523
76	MP0006035_abnormal_mitochondrial_morpho	0.79400859
77	MP0001919_abnormal_reproductive_system	0.79153320
78	MP0002210_abnormal_sex_determination	0.79019223
79	MP0009333_abnormal_splenocyte_physiolog	0.77021817
80	MP0008789_abnormal_olfactory_epithelium	0.76916075
81	MP0008875_abnormal_xenobiotic_pharmacok	0.74664801
82	MP0000631_abnormal_neuroendocrine_gland	0.72909762
83	MP0005448_abnormal_energy_balance	0.71726555
84	MP0002272_abnormal_nervous_system	0.71382089
85	MP0000372_irregular_coat_pigmentation	0.70243287
86	MP0003567_abnormal_fetal_cardiomyocyte	0.69992796
87	MP0005174_abnormal_tail_pigmentation	0.69076761
88	MP0003959_abnormal_lean_body	0.67545756
89	MP0003724_increased_susceptibility_to	0.67015705
90	MP0001845_abnormal_inflammatory_respons	0.65992600
91	MP0000026_abnormal_inner_ear	0.65424926
92	MP0000477_abnormal_intestine_morphology	0.65136676
93	MP0001529_abnormal_vocalization	0.64469982
94	MP0005195_abnormal_posterior_eye	0.64326108
95	MP0001664_abnormal_digestion	0.64080335
96	MP0003938_abnormal_ear_development	0.63773607
97	MP0002723_abnormal_immune_serum	0.61676651
98	MP0001929_abnormal_gametogenesis	0.61603244
99	MP0008007_abnormal_cellular_replicative	0.61283058
100	MP0001765_abnormal_ion_homeostasis	0.60494639

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the pons (HP:0012110)	6.20925418
2	Abnormality of the pons (HP:0007361)	5.41951121
3	Reticulocytopenia (HP:0001896)	4.81371821
4	Abnormality of cells of the erythroid lineage (HP:0012130)	4.53226022
5	Macrocytic anemia (HP:0001972)	4.39007445
6	Hepatocellular necrosis (HP:0001404)	4.14208847
7	Mitochondrial inheritance (HP:0001427)	4.03996360
8	Acute necrotizing encephalopathy (HP:0006965)	3.75211136
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.68454156
10	Hepatic necrosis (HP:0002605)	3.67523444
11	Increased CSF lactate (HP:0002490)	3.67365565
12	Abnormal number of erythroid precursors (HP:0012131)	3.51030049
13	Acute encephalopathy (HP:0006846)	3.39896065
14	Congenital, generalized hypertrichosis (HP:0004540)	3.22981332
15	Pallor (HP:0000980)	3.20789282
16	Lipid accumulation in hepatocytes (HP:0006561)	3.08640622
17	Increased hepatocellular lipid droplets (HP:0006565)	3.07339137
18	Increased intramyocellular lipid droplets (HP:0012240)	2.97392774
19	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.93743432
20	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.93743432
21	Progressive macrocephaly (HP:0004481)	2.92764925
22	Polyphagia (HP:0002591)	2.89875217
23	Abnormality of midbrain morphology (HP:0002418)	2.85492497
24	Molar tooth sign on MRI (HP:0002419)	2.85492497
25	Stomatitis (HP:0010280)	2.80113534
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.79675356
27	Abnormality of alanine metabolism (HP:0010916)	2.79675356
28	Hyperalaninemia (HP:0003348)	2.79675356
29	Hyperglycinuria (HP:0003108)	2.76642505
30	Increased serum lactate (HP:0002151)	2.76218083
31	Pancreatic cysts (HP:0001737)	2.74024210
32	Increased muscle lipid content (HP:0009058)	2.72251214
33	Cerebral edema (HP:0002181)	2.72103898
34	Abnormal hemoglobin (HP:0011902)	2.71661675
35	Increased IgM level (HP:0003496)	2.63801953
36	Elevated erythrocyte sedimentation rate (HP:0003565)	2.63301269
37	Bile duct proliferation (HP:0001408)	2.60106675
38	Abnormal biliary tract physiology (HP:0012439)	2.60106675
39	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.59844811
40	Lactic acidosis (HP:0003128)	2.55235073
41	Constricted visual fields (HP:0001133)	2.54110872
42	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.53796106
43	Abnormality of urine glucose concentration (HP:0011016)	2.51442658
44	Glycosuria (HP:0003076)	2.51442658
45	3-Methylglutaconic aciduria (HP:0003535)	2.49718296
46	Absent thumb (HP:0009777)	2.44992969
47	Colon cancer (HP:0003003)	2.43498302
48	True hermaphroditism (HP:0010459)	2.40976856
49	Renal Fanconi syndrome (HP:0001994)	2.40194159
50	Stenosis of the external auditory canal (HP:0000402)	2.35773391
51	Abolished electroretinogram (ERG) (HP:0000550)	2.35151742
52	Congenital stationary night blindness (HP:0007642)	2.34640315
53	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.31981327
54	Rib fusion (HP:0000902)	2.31654400
55	Hyperphosphaturia (HP:0003109)	2.30380667
56	Respiratory failure (HP:0002878)	2.28061918
57	IgG deficiency (HP:0004315)	2.27516316
58	Concave nail (HP:0001598)	2.25568703
59	Abnormality of the labia minora (HP:0012880)	2.24396983
60	Pendular nystagmus (HP:0012043)	2.21692635
61	Pancreatic fibrosis (HP:0100732)	2.18124910
62	Lethargy (HP:0001254)	2.16599042
63	Abnormality of serine family amino acid metabolism (HP:0010894)	2.13246923
64	Abnormality of glycine metabolism (HP:0010895)	2.13246923
65	Abnormal rod and cone electroretinograms (HP:0008323)	2.12226190
66	Amniotic constriction ring (HP:0009775)	2.11395068
67	Abnormality of placental membranes (HP:0011409)	2.11395068
68	Exertional dyspnea (HP:0002875)	2.08103935
69	Optic disc pallor (HP:0000543)	2.06946843
70	Partial duplication of the phalanx of hand (HP:0009999)	2.00826630
71	Abnormal urine phosphate concentration (HP:0012599)	1.99431550
72	Hyperglycinemia (HP:0002154)	1.98845107
73	CNS demyelination (HP:0007305)	1.95663184
74	Increased serum pyruvate (HP:0003542)	1.95306786
75	Septo-optic dysplasia (HP:0100842)	1.94778997
76	Respiratory difficulties (HP:0002880)	1.93351041
77	Carpal bone hypoplasia (HP:0001498)	1.93030962
78	Sclerocornea (HP:0000647)	1.92241330
79	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.88021702
80	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.88021702
81	Autoimmune thrombocytopenia (HP:0001973)	1.87790664
82	Depressed nasal ridge (HP:0000457)	1.84734385
83	Nausea (HP:0002018)	1.83893119
84	Supernumerary bones of the axial skeleton (HP:0009144)	1.83084283
85	Anencephaly (HP:0002323)	1.80312000
86	Aplasia/Hypoplasia of the ulna (HP:0006495)	1.79947221
87	Nephronophthisis (HP:0000090)	1.79216966
88	Thin ribs (HP:0000883)	1.78977248
89	Woolly hair (HP:0002224)	1.78734343
90	Maternal diabetes (HP:0009800)	1.77865994
91	Partial duplication of thumb phalanx (HP:0009944)	1.76650137
92	Chronic hepatic failure (HP:0100626)	1.76190853
93	Oligomenorrhea (HP:0000876)	1.76182218
94	Male pseudohermaphroditism (HP:0000037)	1.74466079
95	Abnormal eating behavior (HP:0100738)	1.73938321
96	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.73716699
97	Aplasia of the musculature (HP:0100854)	1.72400226
98	Abnormality of serum amino acid levels (HP:0003112)	1.69548086
99	Abnormality of the phalanges of the hallux (HP:0010057)	1.68726290
100	IgA deficiency (HP:0002720)	1.68315465

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	4.42483700
2	KIT	4.01171838
3	BUB1	3.32344846
4	TXK	3.03481826
5	VRK2	2.83356258
6	BCKDK	2.43901150
7	TLK1	2.38363776
8	GRK1	2.36909328
9	CDK19	2.30708641
10	TEC	2.09529629
11	EPHB2	2.07451997
12	DYRK2	1.99877959
13	SRPK1	1.96556084
14	CCNB1	1.91090767
15	NUAK1	1.88524140
16	TAF1	1.77204638
17	MAP4K2	1.72796257
18	PASK	1.68558119
19	NEK1	1.54910852
20	NME2	1.54095216
21	PLK4	1.52987346
22	ACVR1B	1.52196518
23	MAP4K1	1.51139940
24	ADRBK2	1.48218783
25	CDC7	1.39235510
26	VRK1	1.38391995
27	FRK	1.34526704
28	WNK3	1.32537199
29	DAPK2	1.28524406
30	LRRK2	1.26452216
31	MAP3K11	1.24818550
32	TSSK6	1.22278172
33	ZAK	1.20425046
34	PDK2	1.17586134
35	PLK3	1.13888364
36	AURKB	1.07326680
37	EIF2AK1	1.05820661
38	IKBKE	1.05620405
39	CSNK1G2	1.02393856
40	PIK3CA	1.00415314
41	SYK	0.99640940
42	BTK	0.97783175
43	MAP2K2	0.97749523
44	EIF2AK3	0.95607956
45	NME1	0.95105628
46	TRIM28	0.87042505
47	CSNK2A2	0.86995716
48	TGFBR1	0.85687232
49	IKBKB	0.84410765
50	ITK	0.80387496
51	TYK2	0.79384141
52	PINK1	0.77060738
53	DAPK3	0.76740877
54	OXSR1	0.76631833
55	WNK4	0.74971270
56	CHEK2	0.73835336
57	CSNK1G3	0.72526403
58	NEK2	0.63844789
59	PHKG2	0.63412579
60	PHKG1	0.63412579
61	PNCK	0.63165460
62	CSNK1E	0.62455706
63	INSRR	0.62198554
64	CSNK2A1	0.61908546
65	PRKCI	0.61871944
66	BRSK2	0.60542289
67	MKNK1	0.60338063
68	AURKA	0.58006441
69	PRKG1	0.57965096
70	PRKCG	0.56283004
71	CSNK1G1	0.53541466
72	EIF2AK2	0.53439755
73	NTRK2	0.52813136
74	CAMK1	0.52528379
75	MKNK2	0.48216193
76	CSNK1A1	0.48152837
77	RPS6KA6	0.48076965
78	RPS6KA5	0.48035205
79	LCK	0.47788689
80	TAOK3	0.47552221
81	EGFR	0.47122688
82	PRKACA	0.47090825
83	PRKCQ	0.46241510
84	MAP3K10	0.45688749
85	CAMKK2	0.41934221
86	CAMKK1	0.38475167
87	ABL2	0.36836262
88	LYN	0.36627661
89	BRAF	0.35313178
90	DAPK1	0.34887508
91	GRK7	0.34088535
92	PRKCD	0.34041847
93	PLK1	0.33881396
94	PRKACG	0.33680140
95	PRKCA	0.32832568
96	FES	0.32533507
97	ADRBK1	0.32053223
98	LIMK1	0.31917834
99	MINK1	0.29280077
100	IGF1R	0.27632072

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.78933971
2	Asthma_Homo sapiens_hsa05310	4.20774421
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.58866705
4	Parkinsons disease_Homo sapiens_hsa05012	3.26969155
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.54944795
6	Proteasome_Homo sapiens_hsa03050	2.46609648
7	Huntingtons disease_Homo sapiens_hsa05016	2.20319155
8	Allograft rejection_Homo sapiens_hsa05330	2.16716982
9	Alzheimers disease_Homo sapiens_hsa05010	2.15963267
10	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.09253583
11	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.99604547
12	Homologous recombination_Homo sapiens_hsa03440	1.99148854
13	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.98019592
14	RNA polymerase_Homo sapiens_hsa03020	1.94472964
15	Fat digestion and absorption_Homo sapiens_hsa04975	1.76757273
16	Graft-versus-host disease_Homo sapiens_hsa05332	1.75894160
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.72162092
18	Sulfur relay system_Homo sapiens_hsa04122	1.53197306
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.46738595
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45994459
21	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43402696
22	Protein export_Homo sapiens_hsa03060	1.41461942
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.41101522
24	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36651546
25	One carbon pool by folate_Homo sapiens_hsa00670	1.36512552
26	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.30140513
27	Primary immunodeficiency_Homo sapiens_hsa05340	1.26163268
28	Chemical carcinogenesis_Homo sapiens_hsa05204	1.25550110
29	RNA degradation_Homo sapiens_hsa03018	1.24948505
30	Caffeine metabolism_Homo sapiens_hsa00232	1.24867050
31	Type I diabetes mellitus_Homo sapiens_hsa04940	1.22700039
32	Basal transcription factors_Homo sapiens_hsa03022	1.21747173
33	Sulfur metabolism_Homo sapiens_hsa00920	1.21421950
34	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.18658026
35	Tryptophan metabolism_Homo sapiens_hsa00380	1.17608240
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.16961985
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.16075545
38	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13185956
39	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.13084308
40	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12780559
41	Folate biosynthesis_Homo sapiens_hsa00790	1.10559484
42	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.06156750
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.05735538
44	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03817888
45	Spliceosome_Homo sapiens_hsa03040	1.03381867
46	Antigen processing and presentation_Homo sapiens_hsa04612	1.02570924
47	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.98696972
48	Histidine metabolism_Homo sapiens_hsa00340	0.98594144
49	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.98172357
50	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88860397
51	Phototransduction_Homo sapiens_hsa04744	0.86144064
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85262621
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.85031779
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84512500
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.83437851
56	Glutathione metabolism_Homo sapiens_hsa00480	0.82754282
57	Rheumatoid arthritis_Homo sapiens_hsa05323	0.81381886
58	Retinol metabolism_Homo sapiens_hsa00830	0.77267595
59	Purine metabolism_Homo sapiens_hsa00230	0.77148937
60	Mismatch repair_Homo sapiens_hsa03430	0.75988514
61	Base excision repair_Homo sapiens_hsa03410	0.75679910
62	RNA transport_Homo sapiens_hsa03013	0.74800295
63	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.68329069
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.67429937
65	Fatty acid degradation_Homo sapiens_hsa00071	0.64547674
66	Propanoate metabolism_Homo sapiens_hsa00640	0.63164118
67	Metabolic pathways_Homo sapiens_hsa01100	0.61531732
68	Butanoate metabolism_Homo sapiens_hsa00650	0.60802702
69	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.60523520
70	Glycerolipid metabolism_Homo sapiens_hsa00561	0.59498806
71	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.56489992
72	Viral myocarditis_Homo sapiens_hsa05416	0.55701596
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.55531811
74	Fatty acid elongation_Homo sapiens_hsa00062	0.55244910
75	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.53854249
76	Mineral absorption_Homo sapiens_hsa04978	0.53418074
77	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53160910
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.52671497
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.51791223
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50608878
81	DNA replication_Homo sapiens_hsa03030	0.49801562
82	Steroid biosynthesis_Homo sapiens_hsa00100	0.47015661
83	Peroxisome_Homo sapiens_hsa04146	0.46077701
84	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.45639533
85	Selenocompound metabolism_Homo sapiens_hsa00450	0.40893538
86	Renin-angiotensin system_Homo sapiens_hsa04614	0.39227723
87	Basal cell carcinoma_Homo sapiens_hsa05217	0.38647595
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36845576
89	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.35335915
90	Arginine and proline metabolism_Homo sapiens_hsa00330	0.32341252
91	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.29291212
92	Protein digestion and absorption_Homo sapiens_hsa04974	0.28541108
93	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.28433848
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.25043593
95	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.24353091
96	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.22619522
97	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.21246339
98	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.21166965
99	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.20966428
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.20782317

RPL7AP58

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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