ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	chaperone-mediated protein transport (GO:0072321)	5.07214218
2	maturation of 5.8S rRNA (GO:0000460)	4.95033670
3	DNA deamination (GO:0045006)	4.67295058
4	nucleotide transmembrane transport (GO:1901679)	4.48186167
5	ATP synthesis coupled proton transport (GO:0015986)	4.43327144
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.43327144
7	protein complex biogenesis (GO:0070271)	4.32565462
8	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.28083023
9	ribosomal small subunit assembly (GO:0000028)	4.13537970
10	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.09394462
11	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.09394462
12	NADH dehydrogenase complex assembly (GO:0010257)	4.09394462
13	ribosomal small subunit biogenesis (GO:0042274)	4.00422477
14	water-soluble vitamin biosynthetic process (GO:0042364)	3.98111715
15	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.92708386
16	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.92166565
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.87605294
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.84756253
19	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.84756253
20	viral transcription (GO:0019083)	3.84313497
21	protein-cofactor linkage (GO:0018065)	3.82637324
22	translational termination (GO:0006415)	3.80885957
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.73680427
24	protein polyglutamylation (GO:0018095)	3.68563393
25	behavioral response to nicotine (GO:0035095)	3.64793412
26	piRNA metabolic process (GO:0034587)	3.59189214
27	respiratory chain complex IV assembly (GO:0008535)	3.54816889
28	protein neddylation (GO:0045116)	3.52415763
29	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.49892030
30	platelet dense granule organization (GO:0060155)	3.46557798
31	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.46281018
32	response to pheromone (GO:0019236)	3.46044672
33	cotranslational protein targeting to membrane (GO:0006613)	3.40659069
34	translational elongation (GO:0006414)	3.40195112
35	protein targeting to ER (GO:0045047)	3.37095766
36	rRNA catabolic process (GO:0016075)	3.28809451
37	intracellular protein transmembrane import (GO:0044743)	3.25887797
38	meiotic chromosome segregation (GO:0045132)	3.23817606
39	GTP biosynthetic process (GO:0006183)	3.22069345
40	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.21212962
41	protein localization to endoplasmic reticulum (GO:0070972)	3.16961788
42	cytochrome complex assembly (GO:0017004)	3.16034753
43	protein deneddylation (GO:0000338)	3.14766797
44	glycerophospholipid catabolic process (GO:0046475)	3.11949463
45	maturation of SSU-rRNA (GO:0030490)	3.11794911
46	cellular component biogenesis (GO:0044085)	3.11357754
47	DNA methylation involved in gamete generation (GO:0043046)	3.08064788
48	electron transport chain (GO:0022900)	3.03060928
49	respiratory electron transport chain (GO:0022904)	3.02731608
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.02392411
51	termination of RNA polymerase III transcription (GO:0006386)	3.02392411
52	preassembly of GPI anchor in ER membrane (GO:0016254)	3.00123585
53	tryptophan catabolic process (GO:0006569)	2.98252026
54	indole-containing compound catabolic process (GO:0042436)	2.98252026
55	indolalkylamine catabolic process (GO:0046218)	2.98252026
56	cellular protein complex disassembly (GO:0043624)	2.95767674
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.94124610
58	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.93471017
59	cullin deneddylation (GO:0010388)	2.91632078
60	peptidyl-histidine modification (GO:0018202)	2.91417685
61	negative regulation of mast cell activation (GO:0033004)	2.89951507
62	nonmotile primary cilium assembly (GO:0035058)	2.88912891
63	ATP biosynthetic process (GO:0006754)	2.85299957
64	cell proliferation in forebrain (GO:0021846)	2.81154279
65	viral life cycle (GO:0019058)	2.80793318
66	axoneme assembly (GO:0035082)	2.80685491
67	aromatic amino acid family catabolic process (GO:0009074)	2.80136451
68	translation (GO:0006412)	2.79153728
69	epithelial cilium movement (GO:0003351)	2.76893067
70	mannosylation (GO:0097502)	2.76393424
71	rRNA metabolic process (GO:0016072)	2.76300584
72	rRNA processing (GO:0006364)	2.71944206
73	translational initiation (GO:0006413)	2.71060611
74	negative regulation of telomere maintenance (GO:0032205)	2.70148233
75	ribonucleoprotein complex biogenesis (GO:0022613)	2.69921306
76	tRNA processing (GO:0008033)	2.67957116
77	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.67206940
78	UTP biosynthetic process (GO:0006228)	2.67005685
79	indolalkylamine metabolic process (GO:0006586)	2.66774430
80	regulation of cilium movement (GO:0003352)	2.66430977
81	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63326384
82	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.61999302
83	adaptation of signaling pathway (GO:0023058)	2.61950164
84	intracellular protein transmembrane transport (GO:0065002)	2.61826044
85	behavioral response to ethanol (GO:0048149)	2.61361800
86	nucleoside diphosphate phosphorylation (GO:0006165)	2.61154083
87	nucleoside transmembrane transport (GO:1901642)	2.60443637
88	positive regulation of meiosis (GO:0045836)	2.60274764
89	regulation of meiosis I (GO:0060631)	2.59959057
90	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	2.59756428
91	L-phenylalanine catabolic process (GO:0006559)	2.59756428
92	photoreceptor cell maintenance (GO:0045494)	2.59517234
93	protein import into peroxisome matrix (GO:0016558)	2.57070299
94	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.55719474
95	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.55491238
96	lipopolysaccharide biosynthetic process (GO:0009103)	2.54719287
97	kynurenine metabolic process (GO:0070189)	2.53345863
98	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.52683121
99	amine catabolic process (GO:0009310)	2.52646539
100	cellular biogenic amine catabolic process (GO:0042402)	2.52646539

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.65536981
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.39469307
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.32388953
4	VDR_22108803_ChIP-Seq_LS180_Human	3.31402880
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.30395178
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.04244699
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95924129
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.93022741
9	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.72421125
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.61018758
11	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.57525382
12	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.46149729
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.25871332
14	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.25091605
15	GBX2_23144817_ChIP-Seq_PC3_Human	2.16970988
16	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.00256006
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99832076
18	ELK1_19687146_ChIP-ChIP_HELA_Human	1.96641262
19	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94181309
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.88457883
21	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.82547089
22	FUS_26573619_Chip-Seq_HEK293_Human	1.78333164
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.74390492
24	TP53_22573176_ChIP-Seq_HFKS_Human	1.74261148
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.73068504
26	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.70164100
27	EWS_26573619_Chip-Seq_HEK293_Human	1.69419191
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65573069
29	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.65351252
30	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.59342879
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.56907886
32	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.54989487
33	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.54491141
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.54287323
35	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.51581213
36	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.45612578
37	P300_19829295_ChIP-Seq_ESCs_Human	1.44840106
38	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.44395344
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.44220638
40	MYC_18940864_ChIP-ChIP_HL60_Human	1.43401741
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41156096
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.38638338
43	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.37926204
44	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.36522860
45	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.35878488
46	NCOR_22424771_ChIP-Seq_293T_Human	1.34905167
47	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.30748554
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24786302
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.24503078
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.24503078
51	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.23273023
52	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.23273023
53	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.22149654
54	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.18878873
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.17949627
56	AR_20517297_ChIP-Seq_VCAP_Human	1.15760659
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.14714064
58	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.14102902
59	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.13057407
60	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.10540172
61	TTF2_22483619_ChIP-Seq_HELA_Human	1.10046102
62	NANOG_20526341_ChIP-Seq_ESCs_Human	1.07044520
63	ER_23166858_ChIP-Seq_MCF-7_Human	1.06909283
64	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.05162501
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.04581292
66	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.03929852
67	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02496792
68	GABP_19822575_ChIP-Seq_HepG2_Human	1.02202666
69	MYC_19829295_ChIP-Seq_ESCs_Human	1.01768733
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.01552689
71	CBP_20019798_ChIP-Seq_JUKART_Human	1.01038035
72	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.01038035
73	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00580432
74	HTT_18923047_ChIP-ChIP_STHdh_Human	0.98795300
75	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.98710500
76	REST_21632747_ChIP-Seq_MESCs_Mouse	0.98087880
77	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98074391
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.97961203
79	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97615198
80	TCF4_22108803_ChIP-Seq_LS180_Human	0.96931790
81	AR_25329375_ChIP-Seq_VCAP_Human	0.96881539
82	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.96596262
83	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.94970054
84	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.94679887
85	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94445237
86	BCAT_22108803_ChIP-Seq_LS180_Human	0.93891332
87	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.92990425
88	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.92769594
89	HOXB7_26014856_ChIP-Seq_BT474_Human	0.92625499
90	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92034366
91	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.91977067
92	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.91398664
93	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.91015207
94	P53_21459846_ChIP-Seq_SAOS-2_Human	0.90709070
95	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.90638389
96	KDM5A_27292631_Chip-Seq_BREAST_Human	0.90471115
97	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.90100947
98	SMAD4_21799915_ChIP-Seq_A2780_Human	0.89400622
99	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.89269823
100	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.88980905

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	4.81010177
2	MP0002254_reproductive_system_inflammat	4.19536700
3	MP0002876_abnormal_thyroid_physiology	3.12354553
4	MP0006292_abnormal_olfactory_placode	2.78601650
5	MP0003646_muscle_fatigue	2.73619653
6	MP0006072_abnormal_retinal_apoptosis	2.62813691
7	MP0001968_abnormal_touch/_nociception	2.43136577
8	MP0008877_abnormal_DNA_methylation	2.42851509
9	MP0009379_abnormal_foot_pigmentation	2.39619785
10	MP0002163_abnormal_gland_morphology	2.36540014
11	MP0002638_abnormal_pupillary_reflex	2.34306724
12	MP0004885_abnormal_endolymph	2.12501078
13	MP0002653_abnormal_ependyma_morphology	2.05481625
14	MP0008789_abnormal_olfactory_epithelium	2.00428733
15	MP0005379_endocrine/exocrine_gland_phen	1.93747714
16	MP0004142_abnormal_muscle_tone	1.90844384
17	MP0002736_abnormal_nociception_after	1.75881028
18	MP0003787_abnormal_imprinting	1.72170625
19	MP0005645_abnormal_hypothalamus_physiol	1.69203881
20	MP0001529_abnormal_vocalization	1.67773112
21	MP0005253_abnormal_eye_physiology	1.64477289
22	MP0003011_delayed_dark_adaptation	1.63799412
23	MP0002160_abnormal_reproductive_system	1.63119605
24	MP0005551_abnormal_eye_electrophysiolog	1.63084350
25	MP0005646_abnormal_pituitary_gland	1.61158431
26	MP0009046_muscle_twitch	1.54802345
27	MP0000569_abnormal_digit_pigmentation	1.51721017
28	MP0009745_abnormal_behavioral_response	1.49144670
29	MP0002095_abnormal_skin_pigmentation	1.48441473
30	MP0008872_abnormal_physiological_respon	1.46436693
31	MP0005389_reproductive_system_phenotype	1.43221271
32	MP0002272_abnormal_nervous_system	1.40338284
33	MP0006082_CNS_inflammation	1.39988000
34	MP0003879_abnormal_hair_cell	1.38666557
35	MP0006276_abnormal_autonomic_nervous	1.37292759
36	MP0002938_white_spotting	1.37275851
37	MP0001986_abnormal_taste_sensitivity	1.35249100
38	MP0005174_abnormal_tail_pigmentation	1.33669617
39	MP0002102_abnormal_ear_morphology	1.31839323
40	MP0005394_taste/olfaction_phenotype	1.29337769
41	MP0005499_abnormal_olfactory_system	1.29337769
42	MP0001485_abnormal_pinna_reflex	1.27808087
43	MP0001984_abnormal_olfaction	1.26848826
44	MP0001905_abnormal_dopamine_level	1.23388992
45	MP0003122_maternal_imprinting	1.21899791
46	MP0000631_abnormal_neuroendocrine_gland	1.21765840
47	MP0002735_abnormal_chemical_nociception	1.21310432
48	MP0005084_abnormal_gallbladder_morpholo	1.19806502
49	MP0003186_abnormal_redox_activity	1.18823068
50	MP0002277_abnormal_respiratory_mucosa	1.17638818
51	MP0000049_abnormal_middle_ear	1.17426203
52	MP0008875_abnormal_xenobiotic_pharmacok	1.16524928
53	MP0004147_increased_porphyrin_level	1.16505415
54	MP0000372_irregular_coat_pigmentation	1.16306509
55	MP0002138_abnormal_hepatobiliary_system	1.16059330
56	MP0008058_abnormal_DNA_repair	1.15761938
57	MP0004043_abnormal_pH_regulation	1.15389778
58	MP0003195_calcinosis	1.13408011
59	MP0005171_absent_coat_pigmentation	1.12942713
60	MP0003786_premature_aging	1.10065900
61	MP0002557_abnormal_social/conspecific_i	1.09822366
62	MP0009780_abnormal_chondrocyte_physiolo	1.09147214
63	MP0001873_stomach_inflammation	1.07443980
64	MP0006036_abnormal_mitochondrial_physio	1.04130410
65	MP0000427_abnormal_hair_cycle	1.01864551
66	MP0001944_abnormal_pancreas_morphology	1.01728468
67	MP0005671_abnormal_response_to	1.00610987
68	MP0001970_abnormal_pain_threshold	1.00381195
69	MP0002210_abnormal_sex_determination	0.99607628
70	MP0005075_abnormal_melanosome_morpholog	0.96502440
71	MP0000613_abnormal_salivary_gland	0.96313200
72	MP0001348_abnormal_lacrimal_gland	0.94810597
73	MP0002733_abnormal_thermal_nociception	0.93196767
74	MP0001486_abnormal_startle_reflex	0.91962505
75	MP0001963_abnormal_hearing_physiology	0.90694126
76	MP0005195_abnormal_posterior_eye	0.90350290
77	MP0008995_early_reproductive_senescence	0.89034260
78	MP0002064_seizures	0.88792764
79	MP0003121_genomic_imprinting	0.87594166
80	MP0001919_abnormal_reproductive_system	0.87271035
81	MP0003718_maternal_effect	0.86105134
82	MP0002752_abnormal_somatic_nervous	0.84326148
83	MP0000013_abnormal_adipose_tissue	0.83821910
84	MP0002693_abnormal_pancreas_physiology	0.83583101
85	MP0001293_anophthalmia	0.83230045
86	MP0002234_abnormal_pharynx_morphology	0.82288048
87	MP0001929_abnormal_gametogenesis	0.76795453
88	MP0001501_abnormal_sleep_pattern	0.75909633
89	MP0004742_abnormal_vestibular_system	0.75728282
90	MP0000026_abnormal_inner_ear	0.75666154
91	MP0002229_neurodegeneration	0.75573986
92	MP0004133_heterotaxia	0.75259185
93	MP0002572_abnormal_emotion/affect_behav	0.73762546
94	MP0000015_abnormal_ear_pigmentation	0.73286673
95	MP0006035_abnormal_mitochondrial_morpho	0.73237919
96	MP0002184_abnormal_innervation	0.72990792
97	MP0000653_abnormal_sex_gland	0.72695991
98	MP0002734_abnormal_mechanical_nocicepti	0.72561744
99	MP0004145_abnormal_muscle_electrophysio	0.72540333
100	MP0001145_abnormal_male_reproductive	0.72372217

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.76006226
2	Mitochondrial inheritance (HP:0001427)	3.66182333
3	Increased CSF lactate (HP:0002490)	3.54926384
4	Abnormality of midbrain morphology (HP:0002418)	3.45341471
5	Molar tooth sign on MRI (HP:0002419)	3.45341471
6	Hyperglycinemia (HP:0002154)	3.39933715
7	Acute encephalopathy (HP:0006846)	3.38836253
8	Hepatocellular necrosis (HP:0001404)	3.31078290
9	Abnormal mitochondria in muscle tissue (HP:0008316)	3.20331972
10	Pancreatic cysts (HP:0001737)	3.15975168
11	Hepatic necrosis (HP:0002605)	3.10095416
12	Renal Fanconi syndrome (HP:0001994)	3.09597792
13	Nephronophthisis (HP:0000090)	3.06407952
14	Progressive macrocephaly (HP:0004481)	3.05688314
15	Methylmalonic acidemia (HP:0002912)	3.03280853
16	Congenital stationary night blindness (HP:0007642)	3.01084680
17	3-Methylglutaconic aciduria (HP:0003535)	2.99203939
18	Medial flaring of the eyebrow (HP:0010747)	2.96642184
19	True hermaphroditism (HP:0010459)	2.96515404
20	Abnormal rod and cone electroretinograms (HP:0008323)	2.91233415
21	Abnormal drinking behavior (HP:0030082)	2.88867355
22	Polydipsia (HP:0001959)	2.88867355
23	Pancreatic fibrosis (HP:0100732)	2.87421855
24	Increased hepatocellular lipid droplets (HP:0006565)	2.81381026
25	Pendular nystagmus (HP:0012043)	2.80480641
26	Asplenia (HP:0001746)	2.73833725
27	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.67875844
28	Intestinal atresia (HP:0011100)	2.65107411
29	Type II lissencephaly (HP:0007260)	2.64616606
30	Abnormality of the renal cortex (HP:0011035)	2.64542085
31	Abnormality of the renal medulla (HP:0100957)	2.59910704
32	Lipid accumulation in hepatocytes (HP:0006561)	2.58791799
33	Glycosuria (HP:0003076)	2.58245588
34	Abnormality of urine glucose concentration (HP:0011016)	2.58245588
35	Methylmalonic aciduria (HP:0012120)	2.47478240
36	Reticulocytopenia (HP:0001896)	2.43793095
37	Abolished electroretinogram (ERG) (HP:0000550)	2.41407531
38	Lactic acidosis (HP:0003128)	2.40355659
39	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.36324177
40	Colon cancer (HP:0003003)	2.32071800
41	Cerebral edema (HP:0002181)	2.30029727
42	Polyuria (HP:0000103)	2.27637504
43	Increased serum lactate (HP:0002151)	2.25314660
44	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.24480252
45	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.24480252
46	Renal cortical cysts (HP:0000803)	2.24024223
47	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.21451650
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.20300124
49	Brushfield spots (HP:0001088)	2.20022904
50	Focal motor seizures (HP:0011153)	2.16051918
51	Chronic hepatic failure (HP:0100626)	2.14839868
52	Respiratory failure (HP:0002878)	2.13652187
53	Optic disc pallor (HP:0000543)	2.12585922
54	Abnormality of renal resorption (HP:0011038)	2.11268575
55	Abnormality of cells of the erythroid lineage (HP:0012130)	2.08330534
56	Abnormality of vitamin B metabolism (HP:0004340)	2.07599568
57	Adrenal hypoplasia (HP:0000835)	2.07099676
58	Disproportionate short-trunk short stature (HP:0003521)	2.06036088
59	Lethargy (HP:0001254)	2.05722906
60	Chorioretinal atrophy (HP:0000533)	2.02404811
61	Abnormality of alanine metabolism (HP:0010916)	2.02358463
62	Hyperalaninemia (HP:0003348)	2.02358463
63	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.02358463
64	Gait imbalance (HP:0002141)	1.98685056
65	Congenital primary aphakia (HP:0007707)	1.97600554
66	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.93592491
67	Hypoplasia of the pons (HP:0012110)	1.92841630
68	Nephrogenic diabetes insipidus (HP:0009806)	1.89886461
69	Macrocytic anemia (HP:0001972)	1.88202149
70	Male pseudohermaphroditism (HP:0000037)	1.87838298
71	Abnormality of macular pigmentation (HP:0008002)	1.84255410
72	Agitation (HP:0000713)	1.83490353
73	Abnormality of serine family amino acid metabolism (HP:0010894)	1.82591370
74	Abnormality of glycine metabolism (HP:0010895)	1.82591370
75	Increased intramyocellular lipid droplets (HP:0012240)	1.80424123
76	Attenuation of retinal blood vessels (HP:0007843)	1.80112263
77	Congenital sensorineural hearing impairment (HP:0008527)	1.79889414
78	Enlarged kidneys (HP:0000105)	1.78575228
79	Retinitis pigmentosa (HP:0000510)	1.77464241
80	Abnormality of serum amino acid levels (HP:0003112)	1.77390477
81	Postaxial foot polydactyly (HP:0001830)	1.76835238
82	Cerebellar dysplasia (HP:0007033)	1.76483837
83	Abnormal urine output (HP:0012590)	1.76389883
84	Lissencephaly (HP:0001339)	1.76379856
85	Congenital hepatic fibrosis (HP:0002612)	1.76270299
86	Hypomagnesemia (HP:0002917)	1.75807403
87	Sclerocornea (HP:0000647)	1.75483366
88	Generalized aminoaciduria (HP:0002909)	1.73839379
89	Female pseudohermaphroditism (HP:0010458)	1.72948029
90	Tubular atrophy (HP:0000092)	1.71780220
91	Polyphagia (HP:0002591)	1.71295365
92	Tubulointerstitial nephritis (HP:0001970)	1.70264922
93	Abnormality of the labia minora (HP:0012880)	1.69707829
94	Progressive inability to walk (HP:0002505)	1.69266323
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.67335395
96	Absent/shortened dynein arms (HP:0200106)	1.67335395
97	Abnormality of the pons (HP:0007361)	1.67203898
98	Cystic liver disease (HP:0006706)	1.65659886
99	Increased corneal curvature (HP:0100692)	1.65530878
100	Keratoconus (HP:0000563)	1.65530878

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.53195290
2	WNK3	3.17952990
3	ZAK	2.96480589
4	STK38L	2.78011513
5	BCKDK	2.75646868
6	WNK4	2.50000350
7	MAP4K2	2.44770136
8	ADRBK2	2.40571141
9	TAF1	2.26350401
10	GRK1	2.23625614
11	TXK	2.22927585
12	PASK	2.11718904
13	NUAK1	1.98973843
14	CDK19	1.92488603
15	TLK1	1.92311236
16	VRK2	1.90875929
17	TIE1	1.77530213
18	BMPR1B	1.75215401
19	MAP3K12	1.63252661
20	MAP3K4	1.63128220
21	ACVR1B	1.62603160
22	PHKG1	1.62463030
23	PHKG2	1.62463030
24	INSRR	1.60879665
25	DYRK2	1.59625981
26	EIF2AK3	1.48313576
27	MST4	1.48251566
28	STK16	1.44215367
29	MAP3K13	1.39549043
30	LIMK1	1.32035294
31	STK39	1.31116927
32	PDK2	1.22172722
33	MAPK13	1.20102997
34	PINK1	1.20031990
35	VRK1	1.19609091
36	CSNK1G1	1.13287569
37	MAP2K7	1.11015619
38	OXSR1	1.03687164
39	CSNK1G3	1.02313449
40	CSNK1G2	0.97659145
41	DAPK2	0.94708622
42	CSNK1A1L	0.90003045
43	PRKCG	0.88685968
44	RPS6KA5	0.85307911
45	NME2	0.80204226
46	TAOK3	0.78109514
47	CASK	0.75595573
48	LATS1	0.75408374
49	CHEK2	0.74306478
50	ITK	0.73363198
51	NLK	0.71783682
52	PRKCE	0.71413329
53	PAK3	0.71162642
54	AURKA	0.69315955
55	IKBKB	0.68713306
56	PLK4	0.67066639
57	PLK1	0.66664879
58	TGFBR1	0.63919737
59	PRKCQ	0.63643192
60	PRKCI	0.61368302
61	MAP2K6	0.58810833
62	MARK1	0.58571296
63	CDK8	0.56894915
64	PRKACA	0.56349928
65	ATR	0.54745244
66	PRKG2	0.54744250
67	ADRBK1	0.54339272
68	OBSCN	0.54314890
69	DAPK1	0.54181590
70	STK38	0.51829155
71	STK3	0.51040062
72	PLK3	0.49509912
73	SRPK1	0.49252472
74	MUSK	0.49036987
75	CAMKK2	0.47523825
76	PKN1	0.47147236
77	ATM	0.43625686
78	ABL2	0.43069067
79	CSNK2A2	0.42759270
80	IKBKE	0.40610140
81	CSNK2A1	0.40447106
82	MAP2K2	0.40307575
83	CAMKK1	0.37606739
84	CAMK2D	0.37032346
85	TNIK	0.36805844
86	PLK2	0.35991076
87	PIM1	0.33891372
88	STK11	0.32816818
89	KIT	0.31884675
90	AKT2	0.31857273
91	PRKCA	0.31617578
92	CSNK1A1	0.31250968
93	NEK2	0.30896011
94	DAPK3	0.29588543
95	TEC	0.29233913
96	SGK1	0.28750754
97	EPHA4	0.28548009
98	CSNK1D	0.26715049
99	NME1	0.25900742
100	TNK2	0.25854303

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.96505869
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.60562533
3	Parkinsons disease_Homo sapiens_hsa05012	2.87277766
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.63292866
5	Protein export_Homo sapiens_hsa03060	2.52970175
6	RNA polymerase_Homo sapiens_hsa03020	2.38914989
7	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.28675709
8	Phototransduction_Homo sapiens_hsa04744	2.17803239
9	Sulfur metabolism_Homo sapiens_hsa00920	2.14496168
10	Proteasome_Homo sapiens_hsa03050	2.12404194
11	RNA degradation_Homo sapiens_hsa03018	2.06219136
12	Huntingtons disease_Homo sapiens_hsa05016	2.00863316
13	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.92495786
14	Basal transcription factors_Homo sapiens_hsa03022	1.89851993
15	Alzheimers disease_Homo sapiens_hsa05010	1.89688728
16	Cardiac muscle contraction_Homo sapiens_hsa04260	1.71422857
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.69443732
18	Sulfur relay system_Homo sapiens_hsa04122	1.62580347
19	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.57554506
20	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.56546918
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.51739544
22	Propanoate metabolism_Homo sapiens_hsa00640	1.47406240
23	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.45887511
24	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.43436974
25	Butanoate metabolism_Homo sapiens_hsa00650	1.38354641
26	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34895616
27	Folate biosynthesis_Homo sapiens_hsa00790	1.27510798
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.27160527
29	Ether lipid metabolism_Homo sapiens_hsa00565	1.26743634
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.25332360
31	Homologous recombination_Homo sapiens_hsa03440	1.24155816
32	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.23626215
33	Pyrimidine metabolism_Homo sapiens_hsa00240	1.23492385
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20713607
35	Type I diabetes mellitus_Homo sapiens_hsa04940	1.16883303
36	Regulation of autophagy_Homo sapiens_hsa04140	1.16678793
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.15738255
38	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.14890410
39	One carbon pool by folate_Homo sapiens_hsa00670	1.13384041
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.12242460
41	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.11229989
42	Collecting duct acid secretion_Homo sapiens_hsa04966	1.10618750
43	Caffeine metabolism_Homo sapiens_hsa00232	1.09097044
44	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.08802372
45	Asthma_Homo sapiens_hsa05310	1.08353663
46	Peroxisome_Homo sapiens_hsa04146	1.08259075
47	Non-homologous end-joining_Homo sapiens_hsa03450	1.00628564
48	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.00324577
49	Nitrogen metabolism_Homo sapiens_hsa00910	0.96458948
50	Purine metabolism_Homo sapiens_hsa00230	0.94187642
51	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.93849883
52	Fatty acid elongation_Homo sapiens_hsa00062	0.87808245
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.87664455
54	Nicotine addiction_Homo sapiens_hsa05033	0.87123816
55	Allograft rejection_Homo sapiens_hsa05330	0.86562032
56	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85158009
57	Metabolic pathways_Homo sapiens_hsa01100	0.85073523
58	Insulin secretion_Homo sapiens_hsa04911	0.84782354
59	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.84454434
60	Primary immunodeficiency_Homo sapiens_hsa05340	0.79732255
61	RNA transport_Homo sapiens_hsa03013	0.79555723
62	Olfactory transduction_Homo sapiens_hsa04740	0.77763984
63	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77044547
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.75170480
65	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.73501694
66	Retinol metabolism_Homo sapiens_hsa00830	0.71953048
67	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71719008
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.70317564
69	Fat digestion and absorption_Homo sapiens_hsa04975	0.67861243
70	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65846902
71	Chemical carcinogenesis_Homo sapiens_hsa05204	0.65266429
72	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.65099118
73	Glutathione metabolism_Homo sapiens_hsa00480	0.64815205
74	Base excision repair_Homo sapiens_hsa03410	0.62107550
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.61708267
76	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.60153999
77	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59384383
78	Nucleotide excision repair_Homo sapiens_hsa03420	0.57623002
79	Rheumatoid arthritis_Homo sapiens_hsa05323	0.57432729
80	Spliceosome_Homo sapiens_hsa03040	0.55112482
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.53746138
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.52855742
83	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52716548
84	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50652289
85	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49384823
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49148983
87	Morphine addiction_Homo sapiens_hsa05032	0.44312640
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.43887727
89	Fatty acid degradation_Homo sapiens_hsa00071	0.43424861
90	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.42040714
91	Circadian entrainment_Homo sapiens_hsa04713	0.41122790
92	Salivary secretion_Homo sapiens_hsa04970	0.40081683
93	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.39417869
94	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38974653
95	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38550093
96	Taste transduction_Homo sapiens_hsa04742	0.38097283
97	DNA replication_Homo sapiens_hsa03030	0.35387783
98	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.34610081
99	Serotonergic synapse_Homo sapiens_hsa04726	0.33756759
100	Mismatch repair_Homo sapiens_hsa03430	0.29006486

RPL7AP6

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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