RPL7AP60

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)7.15010763
2ribosomal small subunit biogenesis (GO:0042274)7.12123583
3translational termination (GO:0006415)6.85124600
4maturation of SSU-rRNA (GO:0030490)6.71452022
5ribosomal small subunit assembly (GO:0000028)6.60494208
6ATP synthesis coupled proton transport (GO:0015986)6.04999837
7energy coupled proton transport, down electrochemical gradient (GO:0015985)6.04999837
8translational elongation (GO:0006414)5.89563908
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.84389532
10cotranslational protein targeting to membrane (GO:0006613)5.77613873
11protein targeting to ER (GO:0045047)5.74107800
12establishment of protein localization to endoplasmic reticulum (GO:0072599)5.51742361
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.48047861
14protein localization to endoplasmic reticulum (GO:0070972)5.43816372
15mitochondrial respiratory chain complex I biogenesis (GO:0097031)5.19523289
16mitochondrial respiratory chain complex I assembly (GO:0032981)5.19523289
17NADH dehydrogenase complex assembly (GO:0010257)5.19523289
18cellular protein complex disassembly (GO:0043624)5.17340460
19viral life cycle (GO:0019058)5.12094925
20protein complex biogenesis (GO:0070271)5.04050037
21nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.87270421
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.81208064
23translational initiation (GO:0006413)4.56567004
24mitochondrial respiratory chain complex assembly (GO:0033108)4.56412122
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.44404552
26protein complex disassembly (GO:0043241)4.40941637
27chaperone-mediated protein transport (GO:0072321)4.31096547
28macromolecular complex disassembly (GO:0032984)4.25581825
29behavioral response to nicotine (GO:0035095)4.20613010
30protein polyglutamylation (GO:0018095)4.17519292
31respiratory electron transport chain (GO:0022904)4.16382319
32electron transport chain (GO:0022900)4.11949969
33ribosomal large subunit biogenesis (GO:0042273)4.04166142
34translation (GO:0006412)3.89961501
35ATP biosynthetic process (GO:0006754)3.88414874
36protein targeting to membrane (GO:0006612)3.80447482
37cellular component biogenesis (GO:0044085)3.72088075
38protein neddylation (GO:0045116)3.63801525
39purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.62667248
40negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.60030445
41purine nucleoside triphosphate biosynthetic process (GO:0009145)3.58299047
42ribonucleoprotein complex biogenesis (GO:0022613)3.50242954
43cardiovascular system development (GO:0072358)3.47957992
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.47648017
45substrate-independent telencephalic tangential migration (GO:0021826)3.47437275
46substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.47437275
47DNA deamination (GO:0045006)3.40197796
48transcription elongation from RNA polymerase III promoter (GO:0006385)3.37129115
49termination of RNA polymerase III transcription (GO:0006386)3.37129115
50mRNA catabolic process (GO:0006402)3.30335708
51positive regulation of T cell apoptotic process (GO:0070234)3.23572167
52ribonucleoside triphosphate biosynthetic process (GO:0009201)3.18589054
53cell proliferation in forebrain (GO:0021846)3.17581821
54somite development (GO:0061053)3.12593404
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.07659681
56pyrimidine nucleobase catabolic process (GO:0006208)3.06345068
57hydrogen ion transmembrane transport (GO:1902600)3.00135562
58rRNA processing (GO:0006364)2.98637892
59RNA catabolic process (GO:0006401)2.97539784
60rRNA metabolic process (GO:0016072)2.94098472
61tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.94007694
62RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.94007694
63positive regulation of lymphocyte apoptotic process (GO:0070230)2.92751396
64ubiquinone biosynthetic process (GO:0006744)2.87885252
65nucleoside triphosphate biosynthetic process (GO:0009142)2.86784495
66kinetochore assembly (GO:0051382)2.86401951
67protein-cofactor linkage (GO:0018065)2.85704132
68resolution of meiotic recombination intermediates (GO:0000712)2.84779061
69hypothalamus development (GO:0021854)2.84270362
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.84011354
71GTP biosynthetic process (GO:0006183)2.81133101
72peptidyl-histidine modification (GO:0018202)2.78633458
73negative regulation of DNA-templated transcription, elongation (GO:0032785)2.78369446
74proton transport (GO:0015992)2.75017260
75positive regulation of growth hormone secretion (GO:0060124)2.70237914
76respiratory chain complex IV assembly (GO:0008535)2.70112534
77pseudouridine synthesis (GO:0001522)2.70104797
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.68865689
79protein targeting to mitochondrion (GO:0006626)2.68421205
80hydrogen transport (GO:0006818)2.67299806
81establishment of protein localization to membrane (GO:0090150)2.66745176
82pyrimidine nucleotide catabolic process (GO:0006244)2.66732215
83replication fork processing (GO:0031297)2.65685433
84protein targeting (GO:0006605)2.64903143
85establishment of protein localization to mitochondrion (GO:0072655)2.64313992
86regulation of mitochondrial translation (GO:0070129)2.62574898
87epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60740446
88regulation of mitotic spindle checkpoint (GO:1903504)2.59618463
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59618463
90tRNA processing (GO:0008033)2.58206835
91neuron fate determination (GO:0048664)2.58026439
92nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57248364
93positive regulation of fatty acid transport (GO:2000193)2.55884307
94positive regulation of prostaglandin secretion (GO:0032308)2.53720417
95cytochrome complex assembly (GO:0017004)2.53513785
96protein localization to mitochondrion (GO:0070585)2.52485481
97positive regulation of icosanoid secretion (GO:0032305)2.51734729
98negative regulation of transcription regulatory region DNA binding (GO:2000678)2.50741218
99establishment of protein localization to organelle (GO:0072594)2.49557943
100microtubule severing (GO:0051013)2.48835799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.86999806
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.67896038
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.95557323
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.94239713
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.33700252
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.25050503
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.05741983
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.03497401
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.02985582
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60738914
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.41596018
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.31904329
13VDR_23849224_ChIP-Seq_CD4+_Human2.09433675
14ZNF274_21170338_ChIP-Seq_K562_Hela2.05262827
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02538249
16VDR_22108803_ChIP-Seq_LS180_Human2.01324922
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.98911890
18IRF1_19129219_ChIP-ChIP_H3396_Human1.93111409
19MYC_18940864_ChIP-ChIP_HL60_Human1.87483446
20ELF1_17652178_ChIP-ChIP_JURKAT_Human1.86370330
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85301211
22THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85074120
23SRF_21415370_ChIP-Seq_HL-1_Mouse1.83609335
24PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82508781
25CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.78107740
26MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75909646
27CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.74493477
28CBX2_27304074_Chip-Seq_ESCs_Mouse1.70220654
29CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69765708
30XRN2_22483619_ChIP-Seq_HELA_Human1.67587439
31FOXP3_21729870_ChIP-Seq_TREG_Human1.66303650
32TTF2_22483619_ChIP-Seq_HELA_Human1.66119876
33BMI1_23680149_ChIP-Seq_NPCS_Mouse1.62546708
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.55251264
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.55203216
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51819317
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.49327345
38MYC_19079543_ChIP-ChIP_MESCs_Mouse1.48525681
39POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48268022
40GABP_19822575_ChIP-Seq_HepG2_Human1.46356621
41TP53_22573176_ChIP-Seq_HFKS_Human1.46083787
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43977022
43CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41923099
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41428318
45EZH2_27304074_Chip-Seq_ESCs_Mouse1.40060935
46CTCF_18555785_ChIP-Seq_MESCs_Mouse1.38206355
47JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37554940
48ELK1_19687146_ChIP-ChIP_HELA_Human1.34179135
49SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.33641833
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.31124633
51REST_21632747_ChIP-Seq_MESCs_Mouse1.30680171
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29925562
53KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25820549
54RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25573934
55SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25205747
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.24629223
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.24253096
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22941352
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22422323
60RNF2_27304074_Chip-Seq_NSC_Mouse1.19969238
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12422642
62ERA_21632823_ChIP-Seq_H3396_Human1.11613697
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.10748283
64SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09930032
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.09417835
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.08624417
67ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07732807
68NANOG_20526341_ChIP-Seq_ESCs_Human1.07026730
69KDM5A_27292631_Chip-Seq_BREAST_Human1.06839020
70EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.06735714
71FUS_26573619_Chip-Seq_HEK293_Human1.05666694
72FOXP1_21924763_ChIP-Seq_HESCs_Human1.05611093
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05401303
74E2F1_18555785_ChIP-Seq_MESCs_Mouse1.03447868
75CIITA_25753668_ChIP-Seq_RAJI_Human1.02820941
76JARID2_20075857_ChIP-Seq_MESCs_Mouse1.01591183
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.00569306
78TAF2_19829295_ChIP-Seq_ESCs_Human0.99402695
79REST_18959480_ChIP-ChIP_MESCs_Mouse0.98809481
80NCOR_22424771_ChIP-Seq_293T_Human0.98774798
81EED_16625203_ChIP-ChIP_MESCs_Mouse0.98389951
82TP53_20018659_ChIP-ChIP_R1E_Mouse0.98331593
83CTCF_20526341_ChIP-Seq_ESCs_Human0.95678033
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95052472
85AR_20517297_ChIP-Seq_VCAP_Human0.92865247
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92728340
87YY1_22570637_ChIP-Seq_MALME-3M_Human0.91999121
88CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91466466
89TET1_21451524_ChIP-Seq_MESCs_Mouse0.91402244
90MYC_19829295_ChIP-Seq_ESCs_Human0.90056782
91AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89087008
92CTCF_27219007_Chip-Seq_Bcells_Human0.88676173
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.88526349
94EWS_26573619_Chip-Seq_HEK293_Human0.88267993
95ELK1_22589737_ChIP-Seq_MCF10A_Human0.87916253
96SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.87479352
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87389784
98FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.87080964
99BCL6_27268052_Chip-Seq_Bcells_Human0.86885453
100EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.86591313

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.79494149
2MP0006292_abnormal_olfactory_placode3.92576620
3MP0002163_abnormal_gland_morphology3.67351675
4MP0005423_abnormal_somatic_nervous3.19043179
5MP0001986_abnormal_taste_sensitivity3.05991406
6MP0003787_abnormal_imprinting3.05933405
7MP0000569_abnormal_digit_pigmentation2.76202171
8MP0002234_abnormal_pharynx_morphology2.69990630
9MP0008877_abnormal_DNA_methylation2.45501868
10MP0004142_abnormal_muscle_tone2.29720360
11MP0008789_abnormal_olfactory_epithelium2.19445399
12MP0006276_abnormal_autonomic_nervous2.00226279
13MP0003122_maternal_imprinting1.99903915
14MP0005379_endocrine/exocrine_gland_phen1.97969919
15MP0003121_genomic_imprinting1.94697289
16MP0001293_anophthalmia1.93692236
17MP0004147_increased_porphyrin_level1.88661393
18MP0002653_abnormal_ependyma_morphology1.78552332
19MP0002837_dystrophic_cardiac_calcinosis1.78248983
20MP0005499_abnormal_olfactory_system1.77429107
21MP0005394_taste/olfaction_phenotype1.77429107
22MP0003880_abnormal_central_pattern1.76446623
23MP0002102_abnormal_ear_morphology1.67936858
24MP0002876_abnormal_thyroid_physiology1.67078822
25MP0003123_paternal_imprinting1.64951781
26MP0004145_abnormal_muscle_electrophysio1.64572842
27MP0002938_white_spotting1.64248629
28MP0005645_abnormal_hypothalamus_physiol1.63284782
29MP0001905_abnormal_dopamine_level1.63079257
30MP0004885_abnormal_endolymph1.62479367
31MP0003283_abnormal_digestive_organ1.57963517
32MP0001968_abnormal_touch/_nociception1.52441851
33MP0000778_abnormal_nervous_system1.50511916
34MP0000049_abnormal_middle_ear1.47740260
35MP0003186_abnormal_redox_activity1.46433556
36MP0002272_abnormal_nervous_system1.43724012
37MP0002160_abnormal_reproductive_system1.41461251
38MP0009745_abnormal_behavioral_response1.41389855
39MP0002736_abnormal_nociception_after1.40811292
40MP0002095_abnormal_skin_pigmentation1.39246627
41MP0001529_abnormal_vocalization1.34210526
42MP0009046_muscle_twitch1.33374621
43MP0008872_abnormal_physiological_respon1.33254551
44MP0005646_abnormal_pituitary_gland1.27448269
45MP0005551_abnormal_eye_electrophysiolog1.27228054
46MP0000631_abnormal_neuroendocrine_gland1.24723583
47MP0001984_abnormal_olfaction1.20677143
48MP0006072_abnormal_retinal_apoptosis1.18918001
49MP0010030_abnormal_orbit_morphology1.18792404
50MP0002557_abnormal_social/conspecific_i1.18736861
51MP0005389_reproductive_system_phenotype1.17273082
52MP0002733_abnormal_thermal_nociception1.17180639
53MP0008875_abnormal_xenobiotic_pharmacok1.15844009
54MP0005084_abnormal_gallbladder_morpholo1.14628202
55MP0002184_abnormal_innervation1.11837887
56MP0001970_abnormal_pain_threshold1.11721902
57MP0005174_abnormal_tail_pigmentation1.10784318
58MP0008775_abnormal_heart_ventricle1.06103439
59MP0000955_abnormal_spinal_cord1.04166542
60MP0001486_abnormal_startle_reflex1.03114648
61MP0001188_hyperpigmentation1.01938396
62MP0002277_abnormal_respiratory_mucosa1.00376554
63MP0001485_abnormal_pinna_reflex1.00375865
64MP0008058_abnormal_DNA_repair0.99637869
65MP0001919_abnormal_reproductive_system0.98574060
66MP0002752_abnormal_somatic_nervous0.98509792
67MP0002572_abnormal_emotion/affect_behav0.98072669
68MP0000372_irregular_coat_pigmentation0.97145530
69MP0002822_catalepsy0.96175558
70MP0002063_abnormal_learning/memory/cond0.95371485
71MP0003718_maternal_effect0.94311837
72MP0002734_abnormal_mechanical_nocicepti0.93572191
73MP0002210_abnormal_sex_determination0.93103249
74MP0001440_abnormal_grooming_behavior0.92412793
75MP0005195_abnormal_posterior_eye0.90405720
76MP0004742_abnormal_vestibular_system0.88391177
77MP0003635_abnormal_synaptic_transmissio0.87863530
78MP0006036_abnormal_mitochondrial_physio0.86779315
79MP0002138_abnormal_hepatobiliary_system0.86699838
80MP0003786_premature_aging0.84807091
81MP0003878_abnormal_ear_physiology0.84797569
82MP0005377_hearing/vestibular/ear_phenot0.84797569
83MP0002064_seizures0.84758781
84MP0003937_abnormal_limbs/digits/tail_de0.83455648
85MP0003315_abnormal_perineum_morphology0.82223895
86MP0003011_delayed_dark_adaptation0.80947520
87MP0006035_abnormal_mitochondrial_morpho0.80932631
88MP0002233_abnormal_nose_morphology0.80665477
89MP0002638_abnormal_pupillary_reflex0.79095556
90MP0002067_abnormal_sensory_capabilities0.78640818
91MP0005075_abnormal_melanosome_morpholog0.77933666
92MP0003567_abnormal_fetal_cardiomyocyte0.77618892
93MP0003646_muscle_fatigue0.76520647
94MP0000427_abnormal_hair_cycle0.74647696
95MP0000026_abnormal_inner_ear0.74636591
96MP0005386_behavior/neurological_phenoty0.73158138
97MP0004924_abnormal_behavior0.73158138
98MP0001502_abnormal_circadian_rhythm0.72958888
99MP0002882_abnormal_neuron_morphology0.70669277
100MP0000647_abnormal_sebaceous_gland0.70258275

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.15049267
2Abnormality of cells of the erythroid lineage (HP:0012130)4.83078744
3Reticulocytopenia (HP:0001896)4.69612973
4Mitochondrial inheritance (HP:0001427)4.57261546
5Abnormal mitochondria in muscle tissue (HP:0008316)4.56062927
6Acute encephalopathy (HP:0006846)4.40616213
7Progressive macrocephaly (HP:0004481)4.22224770
8Increased CSF lactate (HP:0002490)4.02101299
9Abnormal number of erythroid precursors (HP:0012131)3.91727529
10Colon cancer (HP:0003003)3.90997410
11Hepatocellular necrosis (HP:0001404)3.81203810
12Macrocytic anemia (HP:0001972)3.72441359
13Molar tooth sign on MRI (HP:0002419)3.68928477
14Abnormality of midbrain morphology (HP:0002418)3.68928477
15Increased hepatocellular lipid droplets (HP:0006565)3.53745318
16Lipid accumulation in hepatocytes (HP:0006561)3.48327752
17Hepatic necrosis (HP:0002605)3.38383749
18Pancreatic fibrosis (HP:0100732)3.34359689
19Cerebral edema (HP:0002181)3.24822410
20Renal Fanconi syndrome (HP:0001994)3.23822886
21Medial flaring of the eyebrow (HP:0010747)3.01757224
223-Methylglutaconic aciduria (HP:0003535)2.95777981
23Pancreatic cysts (HP:0001737)2.92462398
24True hermaphroditism (HP:0010459)2.75870953
25Nephronophthisis (HP:0000090)2.69019454
26Absent/shortened dynein arms (HP:0200106)2.61288091
27Dynein arm defect of respiratory motile cilia (HP:0012255)2.61288091
28Pallor (HP:0000980)2.61205789
29Sclerocornea (HP:0000647)2.60787780
30Lactic acidosis (HP:0003128)2.55304426
31Increased intramyocellular lipid droplets (HP:0012240)2.53885779
32Optic disc pallor (HP:0000543)2.53248156
33Increased serum lactate (HP:0002151)2.53215357
34Absent thumb (HP:0009777)2.52490692
35Limb dystonia (HP:0002451)2.42380319
36Congenital malformation of the right heart (HP:0011723)2.40241951
37Double outlet right ventricle (HP:0001719)2.40241951
38Exertional dyspnea (HP:0002875)2.39234167
39Respiratory failure (HP:0002878)2.36786843
40Congenital stationary night blindness (HP:0007642)2.34998264
41Type II lissencephaly (HP:0007260)2.32394512
42Pendular nystagmus (HP:0012043)2.28505650
43Abnormality of renal resorption (HP:0011038)2.28413183
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.27368270
45Abnormal number of incisors (HP:0011064)2.26927938
46Leukodystrophy (HP:0002415)2.26442792
47Increased muscle lipid content (HP:0009058)2.23663743
48Septo-optic dysplasia (HP:0100842)2.19805614
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18188093
50Maternal diabetes (HP:0009800)2.18103599
51Decreased activity of mitochondrial respiratory chain (HP:0008972)2.17827032
52Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.17827032
53Rib fusion (HP:0000902)2.15008508
54Abnormality of DNA repair (HP:0003254)2.14210746
55Tubular atrophy (HP:0000092)2.14050088
56Exercise intolerance (HP:0003546)2.11280227
57Abnormality of the renal cortex (HP:0011035)2.11093814
58Abnormality of the renal medulla (HP:0100957)2.10673838
59Neoplasm of the adrenal cortex (HP:0100641)2.09265030
60Anophthalmia (HP:0000528)2.08343589
61Polyphagia (HP:0002591)2.07492001
62Cystic liver disease (HP:0006706)2.05765297
63Glycosuria (HP:0003076)2.04807156
64Abnormality of urine glucose concentration (HP:0011016)2.04807156
65Hypothermia (HP:0002045)2.04335760
66Absent rod-and cone-mediated responses on ERG (HP:0007688)2.03202254
67Stenosis of the external auditory canal (HP:0000402)1.99656615
68Anencephaly (HP:0002323)1.97878212
69Pachygyria (HP:0001302)1.95796042
70Abnormal drinking behavior (HP:0030082)1.94625011
71Polydipsia (HP:0001959)1.94625011
72Gait imbalance (HP:0002141)1.93762730
73Depressed nasal ridge (HP:0000457)1.92055243
74Lethargy (HP:0001254)1.90964877
75Hyperglycinemia (HP:0002154)1.90252900
76Hypoplasia of the radius (HP:0002984)1.89688272
77Abolished electroretinogram (ERG) (HP:0000550)1.89437183
78Abnormal rod and cone electroretinograms (HP:0008323)1.83812438
79Growth hormone deficiency (HP:0000824)1.82703606
80Hyperphosphaturia (HP:0003109)1.82306122
81Abnormal hemoglobin (HP:0011902)1.81598084
82Abnormal respiratory epithelium morphology (HP:0012253)1.81382554
83Abnormal respiratory motile cilium morphology (HP:0005938)1.81382554
84Hyperglycinuria (HP:0003108)1.79811646
85Congenital primary aphakia (HP:0007707)1.79459333
86Type 2 muscle fiber atrophy (HP:0003554)1.78093495
87Narrow forehead (HP:0000341)1.77851317
88Muscle fiber atrophy (HP:0100295)1.77698365
89Broad-based gait (HP:0002136)1.75984748
90Aplasia/Hypoplasia of the spleen (HP:0010451)1.75125208
91Agitation (HP:0000713)1.74594144
92Lissencephaly (HP:0001339)1.74342767
93Abnormal ciliary motility (HP:0012262)1.72801929
94Renal cortical cysts (HP:0000803)1.72115466
95X-linked dominant inheritance (HP:0001423)1.72104334
96Occipital encephalocele (HP:0002085)1.71169977
97Male pseudohermaphroditism (HP:0000037)1.70987633
98Entropion (HP:0000621)1.70553108
99Nephrogenic diabetes insipidus (HP:0009806)1.70283336
100Optic nerve coloboma (HP:0000588)1.69580270

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.40406937
2NUAK13.48759855
3TAF13.12835581
4TXK2.84978650
5TLK12.78774834
6ZAK2.71550814
7DYRK22.66740881
8VRK12.09993707
9MAP4K22.07405238
10STK161.99984369
11GRK11.93238289
12WNK41.91554650
13ADRBK21.77803984
14BCKDK1.73418364
15CSNK1G21.70718482
16TIE11.70371571
17MAPK131.69707236
18PRKD31.67026240
19SMG11.64200285
20CSNK1G31.60599568
21MAP3K91.48998387
22MAP3K111.42365302
23NME21.39602725
24STK391.39531133
25PHKG21.38824329
26PHKG11.38824329
27PINK11.37390636
28CDC71.33317503
29CDK191.32575072
30CSNK1G11.31871184
31MAP2K21.27550075
32CSNK1A1L1.26053820
33DAPK31.20821688
34WNK31.16216300
35MAPKAPK51.11359832
36OXSR11.01620712
37PIK3CA1.01220054
38MARK11.01064461
39EPHB20.99551877
40MINK10.99337743
41GRK50.99285752
42IKBKB0.94775971
43BMPR1B0.93417835
44FRK0.87068658
45AURKA0.87006380
46CASK0.84943579
47BUB10.84098550
48CAMK10.83467790
49IKBKE0.83242711
50NTRK20.81289261
51DYRK30.80730846
52CHEK20.80487675
53RPS6KA50.80220895
54KIT0.78813924
55LRRK20.78472749
56TAOK30.73054542
57PRKCG0.72129534
58LIMK10.71478362
59MKNK20.69869765
60TYRO30.67437325
61INSRR0.66142501
62PLK30.64991473
63CSNK1E0.64632854
64MAP4K10.63453349
65STK110.63244541
66ABL20.63079586
67CSNK2A20.62971912
68PRKCI0.60839097
69AURKB0.58896575
70MAP2K70.58514739
71CAMK1D0.58393543
72PRKCQ0.56733683
73EIF2AK20.56712722
74BRAF0.53275376
75PRKACA0.52603319
76CAMK40.51399047
77MAP3K120.50861044
78DYRK1A0.50615585
79MKNK10.49410492
80CSNK1A10.49192894
81PAK30.48305025
82PLK40.47984808
83ADRBK10.46789402
84CSNK2A10.44824956
85NEK10.44362057
86CAMKK20.44247593
87DAPK10.41678868
88PLK10.41242741
89RPS6KA60.40233902
90TEC0.40050229
91DAPK20.39539330
92PNCK0.39237821
93ATR0.38355561
94GRK60.37669944
95CAMK1G0.37412454
96ITK0.36743574
97PRKCH0.35209486
98OBSCN0.35036897
99PRKCZ0.34445059
100EPHA40.32114597

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.35683811
2Oxidative phosphorylation_Homo sapiens_hsa001904.72790519
3Parkinsons disease_Homo sapiens_hsa050124.13622724
4Huntingtons disease_Homo sapiens_hsa050162.84363072
5Alzheimers disease_Homo sapiens_hsa050102.77966362
6Cardiac muscle contraction_Homo sapiens_hsa042602.47691425
7Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.44662779
8RNA polymerase_Homo sapiens_hsa030202.42254578
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.23503424
10Linoleic acid metabolism_Homo sapiens_hsa005912.12068270
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.10270161
12Proteasome_Homo sapiens_hsa030502.05943824
13Basal transcription factors_Homo sapiens_hsa030221.84341547
14Homologous recombination_Homo sapiens_hsa034401.81559835
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.80438914
16Protein export_Homo sapiens_hsa030601.80209649
17One carbon pool by folate_Homo sapiens_hsa006701.64488321
18Phototransduction_Homo sapiens_hsa047441.54434769
19Asthma_Homo sapiens_hsa053101.40863210
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.39530644
21Sulfur relay system_Homo sapiens_hsa041221.39387521
22Fanconi anemia pathway_Homo sapiens_hsa034601.35879708
23Pyrimidine metabolism_Homo sapiens_hsa002401.26875378
24RNA degradation_Homo sapiens_hsa030181.24182335
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.22251185
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19309115
27Ether lipid metabolism_Homo sapiens_hsa005651.14412617
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.10148414
29Fat digestion and absorption_Homo sapiens_hsa049751.03756866
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.01916678
31Nicotine addiction_Homo sapiens_hsa050330.97403420
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.96623814
33Nitrogen metabolism_Homo sapiens_hsa009100.96174554
34Caffeine metabolism_Homo sapiens_hsa002320.89765534
35Tryptophan metabolism_Homo sapiens_hsa003800.89126775
36Spliceosome_Homo sapiens_hsa030400.87655215
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84907262
38Purine metabolism_Homo sapiens_hsa002300.83728952
39Nucleotide excision repair_Homo sapiens_hsa034200.83711437
40Systemic lupus erythematosus_Homo sapiens_hsa053220.82532438
41Base excision repair_Homo sapiens_hsa034100.81221506
42Arachidonic acid metabolism_Homo sapiens_hsa005900.80636837
43Propanoate metabolism_Homo sapiens_hsa006400.79627896
44Allograft rejection_Homo sapiens_hsa053300.78759234
45Collecting duct acid secretion_Homo sapiens_hsa049660.78119005
46Non-homologous end-joining_Homo sapiens_hsa034500.77347250
47Folate biosynthesis_Homo sapiens_hsa007900.75589745
48Graft-versus-host disease_Homo sapiens_hsa053320.73120418
49Metabolic pathways_Homo sapiens_hsa011000.72892347
50Peroxisome_Homo sapiens_hsa041460.72489179
51Regulation of autophagy_Homo sapiens_hsa041400.71313868
52DNA replication_Homo sapiens_hsa030300.70013802
53Basal cell carcinoma_Homo sapiens_hsa052170.69960715
54RNA transport_Homo sapiens_hsa030130.69862481
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69395171
56Morphine addiction_Homo sapiens_hsa050320.67669766
57Mismatch repair_Homo sapiens_hsa034300.65890476
58Autoimmune thyroid disease_Homo sapiens_hsa053200.65751283
59Butanoate metabolism_Homo sapiens_hsa006500.65386840
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.65287489
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64490625
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.64342027
63Primary immunodeficiency_Homo sapiens_hsa053400.61026695
64Fatty acid elongation_Homo sapiens_hsa000620.60708396
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60642843
66Serotonergic synapse_Homo sapiens_hsa047260.59023076
67Cyanoamino acid metabolism_Homo sapiens_hsa004600.56725626
68Chemical carcinogenesis_Homo sapiens_hsa052040.51602089
69Taste transduction_Homo sapiens_hsa047420.50274414
70Selenocompound metabolism_Homo sapiens_hsa004500.50188972
71Alcoholism_Homo sapiens_hsa050340.48749718
72Tyrosine metabolism_Homo sapiens_hsa003500.47134608
73Phenylalanine metabolism_Homo sapiens_hsa003600.46826319
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46148998
75Olfactory transduction_Homo sapiens_hsa047400.45933709
76Hedgehog signaling pathway_Homo sapiens_hsa043400.45714597
77Type I diabetes mellitus_Homo sapiens_hsa049400.45708412
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44536614
79Vitamin B6 metabolism_Homo sapiens_hsa007500.43831559
80Insulin secretion_Homo sapiens_hsa049110.43476850
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.41869140
82Sulfur metabolism_Homo sapiens_hsa009200.41745689
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39523992
84Ovarian steroidogenesis_Homo sapiens_hsa049130.39424763
85GABAergic synapse_Homo sapiens_hsa047270.37815376
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.36273244
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.35747051
88Rheumatoid arthritis_Homo sapiens_hsa053230.34219561
89Circadian entrainment_Homo sapiens_hsa047130.33813802
90Retinol metabolism_Homo sapiens_hsa008300.32680021
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32217689
92Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.31736945
93Synaptic vesicle cycle_Homo sapiens_hsa047210.31460079
94Arginine and proline metabolism_Homo sapiens_hsa003300.31180517
95Cocaine addiction_Homo sapiens_hsa050300.31119184
96Dopaminergic synapse_Homo sapiens_hsa047280.29263909
97Glutamatergic synapse_Homo sapiens_hsa047240.27931378
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27588693
99Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.26828070
100Oxytocin signaling pathway_Homo sapiens_hsa049210.25852309

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