RPL7AP64

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.46390544
2negative regulation of cell killing (GO:0031342)6.28873709
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.28873709
4positive regulation by symbiont of host defense response (GO:0052509)6.03100820
5modulation by symbiont of host defense response (GO:0052031)6.03100820
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.03100820
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.03100820
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.03100820
9modulation by symbiont of host immune response (GO:0052553)6.03100820
10neutrophil activation involved in immune response (GO:0002283)5.72563846
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.60203509
12macrophage activation involved in immune response (GO:0002281)5.00721130
13detection of other organism (GO:0098543)4.95503942
14regulation of interferon-beta biosynthetic process (GO:0045357)4.95220257
15immunoglobulin mediated immune response (GO:0016064)4.87986936
16antigen processing and presentation of endogenous antigen (GO:0019883)4.75572634
17regulation of gamma-delta T cell activation (GO:0046643)4.73497098
18negative regulation of interleukin-12 production (GO:0032695)4.66487892
19positive regulation of mast cell activation (GO:0033005)4.66123671
20regulation of B cell receptor signaling pathway (GO:0050855)4.64301828
21detection of bacterium (GO:0016045)4.60499921
22response to peptidoglycan (GO:0032494)4.55486882
23microglial cell activation (GO:0001774)4.52330303
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.46568484
25regulation of mast cell degranulation (GO:0043304)4.13900016
26regulation of mast cell activation (GO:0033003)4.13289481
27cellular extravasation (GO:0045123)4.08348002
28response to host immune response (GO:0052572)4.07586617
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.07586617
30neutrophil activation (GO:0042119)4.05975520
31positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.99518208
32detection of external biotic stimulus (GO:0098581)3.99217149
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.95237341
34negative regulation of T cell mediated immunity (GO:0002710)3.94374879
35antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.93098502
36leukocyte migration involved in inflammatory response (GO:0002523)3.90515726
37positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.90458935
38regulation of mast cell activation involved in immune response (GO:0033006)3.86021127
39positive regulation of mast cell degranulation (GO:0043306)3.86013567
40positive regulation of mast cell activation involved in immune response (GO:0033008)3.86013567
41detection of molecule of bacterial origin (GO:0032490)3.84642590
42B cell mediated immunity (GO:0019724)3.84617394
43myeloid cell activation involved in immune response (GO:0002275)3.83087087
44negative regulation of stress fiber assembly (GO:0051497)3.80870192
45production of molecular mediator involved in inflammatory response (GO:0002532)3.80532143
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.72710926
47response to host (GO:0075136)3.72710926
48response to host defenses (GO:0052200)3.72710926
49negative regulation of erythrocyte differentiation (GO:0045647)3.69365968
50macrophage activation (GO:0042116)3.68535991
51respiratory burst (GO:0045730)3.66130341
52regulation of myeloid leukocyte mediated immunity (GO:0002886)3.64409252
53leukocyte aggregation (GO:0070486)3.64262006
54regulation of gamma-delta T cell differentiation (GO:0045586)3.64173996
55granulocyte activation (GO:0036230)3.62084965
56positive regulation of B cell differentiation (GO:0045579)3.59977613
57detection of biotic stimulus (GO:0009595)3.55574080
58negative regulation of leukocyte mediated immunity (GO:0002704)3.53473760
59interferon-gamma secretion (GO:0072643)3.44201911
60regulation of leukocyte degranulation (GO:0043300)3.43277391
61positive thymic T cell selection (GO:0045059)3.40992525
62positive regulation of interleukin-1 beta secretion (GO:0050718)3.33612110
63positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.30881912
64neutrophil mediated immunity (GO:0002446)3.28074351
65B cell receptor signaling pathway (GO:0050853)3.27938263
66regulation of DNA methylation (GO:0044030)3.26943511
67negative T cell selection (GO:0043383)3.24066182
68cell wall macromolecule metabolic process (GO:0044036)3.23356295
69regulation of tolerance induction (GO:0002643)3.23251456
70positive regulation of interferon-alpha production (GO:0032727)3.21860212
71positive regulation of humoral immune response (GO:0002922)3.16477338
72positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.16341867
73regulation of B cell differentiation (GO:0045577)3.15529918
74activated T cell proliferation (GO:0050798)3.12693554
75leukocyte degranulation (GO:0043299)3.12478186
76regulation of T cell tolerance induction (GO:0002664)3.11984587
77positive regulation of interleukin-1 secretion (GO:0050716)3.11510182
78negative thymic T cell selection (GO:0045060)3.08392507
79regulation of regulatory T cell differentiation (GO:0045589)3.04331072
80antigen processing and presentation via MHC class Ib (GO:0002475)3.02249793
81positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.02211690
82regulation of interleukin-1 beta secretion (GO:0050706)3.00689426
83interferon-gamma-mediated signaling pathway (GO:0060333)2.99142165
84regulation of interferon-alpha production (GO:0032647)2.95133257
85interferon-gamma production (GO:0032609)2.94660776
86regulation of regulated secretory pathway (GO:1903305)2.93413820
87positive T cell selection (GO:0043368)2.93263014
88positive regulation of isotype switching (GO:0045830)2.92303982
89negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.91645847
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.90545276
91regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.89478386
92regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.87340398
93regulation of female gonad development (GO:2000194)2.86023104
94response to interleukin-15 (GO:0070672)2.85839144
95regulation of platelet aggregation (GO:0090330)2.83968151
96negative regulation of innate immune response (GO:0045824)2.82672605
97positive regulation of interleukin-17 production (GO:0032740)2.82502897
98negative regulation of alpha-beta T cell activation (GO:0046636)2.81694055
99regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80889059
100regulation of natural killer cell mediated immunity (GO:0002715)2.80889059

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.42390466
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.23556727
3EZH2_22144423_ChIP-Seq_EOC_Human4.62460023
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.60958431
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.60529696
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.23911782
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.23082286
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.06903870
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.06390560
10RUNX_20019798_ChIP-Seq_JUKART_Human2.96144996
11IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89218370
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81380710
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78503165
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.46734463
15SPI1_23547873_ChIP-Seq_NB4_Human2.45590003
16SPI1_23127762_ChIP-Seq_K562_Human2.43662377
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41457399
18NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.36863750
19VDR_24763502_ChIP-Seq_THP-1_Human2.33247404
20RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.32071819
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.26725849
22SCL_19346495_ChIP-Seq_HPC-7_Human2.22289708
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.22061659
24Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.06800740
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.01972128
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96986790
27MYB_26560356_Chip-Seq_TH2_Human1.96717956
28RUNX1_22412390_ChIP-Seq_EML_Mouse1.94720242
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93875270
30VDR_24787735_ChIP-Seq_THP-1_Human1.92349061
31MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.90270583
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.87130007
33MYB_26560356_Chip-Seq_TH1_Human1.85085818
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80339233
35UTX_26944678_Chip-Seq_JUKART_Human1.78103590
36VDR_21846776_ChIP-Seq_THP-1_Human1.76225132
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.72741304
38GATA3_27048872_Chip-Seq_THYMUS_Human1.72157812
39LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70455088
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.66922946
41MAF_26560356_Chip-Seq_TH1_Human1.63629991
42PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.60948878
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59599599
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.55879335
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.49524089
46CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.42300778
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41200070
48PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39441455
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37099670
50GATA3_26560356_Chip-Seq_TH2_Human1.35556686
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35290076
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.34808548
53GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32709705
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31452423
55CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.28424542
56KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.25843688
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.25843688
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.25843688
59SMRT_27268052_Chip-Seq_Bcells_Human1.21754603
60SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21222821
61SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20367946
62VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.18153266
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15727917
64NOTCH1_21737748_ChIP-Seq_TLL_Human1.14148012
65PU_27001747_Chip-Seq_BMDM_Mouse1.11370370
66GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11369828
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09339544
68BCL6_27268052_Chip-Seq_Bcells_Human1.09098227
69SPI1_20517297_ChIP-Seq_HL60_Human1.07208961
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05472671
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02577031
72TCF7_22412390_ChIP-Seq_EML_Mouse1.02316594
73TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02258374
74SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97791371
75PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97538559
76GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96388647
77MAF_26560356_Chip-Seq_TH2_Human0.95685100
78GATA2_21666600_ChIP-Seq_HMVEC_Human0.95600326
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95016493
80BCOR_27268052_Chip-Seq_Bcells_Human0.94159091
81GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92040008
82DROSHA_22980978_ChIP-Seq_HELA_Human0.92034631
83NANOG_20526341_ChIP-Seq_ESCs_Human0.92005617
84GATA1_19941827_ChIP-Seq_MEL86_Mouse0.91079969
85CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88018323
86GATA2_19941826_ChIP-Seq_K562_Human0.86750280
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.86723660
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81898130
89MYC_22102868_ChIP-Seq_BL_Human0.81816604
90RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80866883
91GATA1_19941826_ChIP-Seq_K562_Human0.80268325
92PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80018499
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79914834
94STAT1_20625510_ChIP-Seq_HELA_Human0.79596598
95CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79371087
96P300_27268052_Chip-Seq_Bcells_Human0.77599148
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77269505
98RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77185996
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.76995102
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76163953

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.46071606
2MP0003436_decreased_susceptibility_to4.09761398
3MP0001835_abnormal_antigen_presentation3.98515878
4MP0005671_abnormal_response_to3.34468588
5MP0002419_abnormal_innate_immunity3.22404432
6MP0006082_CNS_inflammation3.16467962
7MP0000685_abnormal_immune_system2.90510648
8MP0001800_abnormal_humoral_immune2.76440143
9MP0005000_abnormal_immune_tolerance2.74093493
10MP0005025_abnormal_response_to2.69117461
11MP0009785_altered_susceptibility_to2.68069436
12MP0003303_peritoneal_inflammation2.52331861
13MP0002452_abnormal_antigen_presenting2.52238673
14MP0001790_abnormal_immune_system2.51942821
15MP0005387_immune_system_phenotype2.51942821
16MP0002420_abnormal_adaptive_immunity2.50454839
17MP0002723_abnormal_immune_serum2.49670638
18MP0001819_abnormal_immune_cell2.46069027
19MP0005464_abnormal_platelet_physiology2.40782367
20MP0002138_abnormal_hepatobiliary_system2.35024368
21MP0003646_muscle_fatigue2.18919115
22MP0002148_abnormal_hypersensitivity_rea2.16789687
23MP0003828_pulmonary_edema2.07587260
24MP0003183_abnormal_peptide_metabolism2.06414528
25MP0001533_abnormal_skeleton_physiology2.02488935
26MP0003191_abnormal_cellular_cholesterol2.01245570
27MP0002132_abnormal_respiratory_system1.94178271
28MP0004130_abnormal_muscle_cell1.86638003
29MP0000716_abnormal_immune_system1.76375879
30MP0002398_abnormal_bone_marrow1.73468096
31MP0008260_abnormal_autophagy1.73232034
32MP0005646_abnormal_pituitary_gland1.71759602
33MP0002277_abnormal_respiratory_mucosa1.68972864
34MP0003879_abnormal_hair_cell1.67414011
35MP0002405_respiratory_system_inflammati1.60883691
36MP0001845_abnormal_inflammatory_respons1.58107962
37MP0003172_abnormal_lysosome_physiology1.57754542
38MP0000689_abnormal_spleen_morphology1.55738370
39MP0009333_abnormal_splenocyte_physiolog1.54253084
40MP0001853_heart_inflammation1.48159324
41MP0001986_abnormal_taste_sensitivity1.46594830
42MP0010155_abnormal_intestine_physiology1.43568666
43MP0000465_gastrointestinal_hemorrhage1.40711092
44MP0004381_abnormal_hair_follicle1.39918726
45MP0003718_maternal_effect1.36751655
46MP0002722_abnormal_immune_system1.35635585
47MP0005310_abnormal_salivary_gland1.33734084
48MP0003763_abnormal_thymus_physiology1.33368584
49MP0002429_abnormal_blood_cell1.32172168
50MP0003300_gastrointestinal_ulcer1.23406503
51MP0008469_abnormal_protein_level1.22458760
52MP0002998_abnormal_bone_remodeling1.21128143
53MP0008877_abnormal_DNA_methylation1.17248123
54MP0003866_abnormal_defecation1.12293758
55MP0000703_abnormal_thymus_morphology1.12229924
56MP0002166_altered_tumor_susceptibility1.11756290
57MP0004185_abnormal_adipocyte_glucose1.10919581
58MP0005360_urolithiasis1.10493658
59MP0002837_dystrophic_cardiac_calcinosis1.09256139
60MP0006292_abnormal_olfactory_placode1.08108518
61MP0004883_abnormal_blood_vessel1.07764595
62MP0004947_skin_inflammation1.07648682
63MP0005058_abnormal_lysosome_morphology1.05895827
64MP0000858_altered_metastatic_potential1.04339656
65MP0009764_decreased_sensitivity_to1.03396341
66MP0003075_altered_response_to0.99124185
67MP0005397_hematopoietic_system_phenotyp0.96873272
68MP0001545_abnormal_hematopoietic_system0.96873272
69MP0000343_altered_response_to0.95740275
70MP0003690_abnormal_glial_cell0.94986413
71MP0008789_abnormal_olfactory_epithelium0.93706605
72MP0005647_abnormal_sex_gland0.91996536
73MP0005075_abnormal_melanosome_morpholog0.91422876
74MP0008004_abnormal_stomach_pH0.89625199
75MP0005390_skeleton_phenotype0.88027817
76MP0002396_abnormal_hematopoietic_system0.86447915
77MP0001851_eye_inflammation0.86217882
78MP0000015_abnormal_ear_pigmentation0.83773798
79MP0005166_decreased_susceptibility_to0.81978042
80MP0009278_abnormal_bone_marrow0.75439201
81MP0001663_abnormal_digestive_system0.74978267
82MP0009053_abnormal_anal_canal0.74063002
83MP0003448_altered_tumor_morphology0.72929001
84MP0003806_abnormal_nucleotide_metabolis0.72888067
85MP0010234_abnormal_vibrissa_follicle0.71833911
86MP0009763_increased_sensitivity_to0.71405611
87MP0002006_tumorigenesis0.65818607
88MP0005164_abnormal_response_to0.65318059
89MP0004885_abnormal_endolymph0.62294064
90MP0009765_abnormal_xenobiotic_induced0.61673043
91MP0001764_abnormal_homeostasis0.61306263
92MP0000604_amyloidosis0.61022215
93MP0005410_abnormal_fertilization0.61016463
94MP0005083_abnormal_biliary_tract0.60713884
95MP0005394_taste/olfaction_phenotype0.60129349
96MP0005499_abnormal_olfactory_system0.60129349
97MP0000470_abnormal_stomach_morphology0.58717109
98MP0010678_abnormal_skin_adnexa0.57952447
99MP0004142_abnormal_muscle_tone0.52067610
100MP0001915_intracranial_hemorrhage0.51720498

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.02192672
2Recurrent bacterial skin infections (HP:0005406)5.96605504
3Recurrent abscess formation (HP:0002722)5.89933771
4Abnormality of macrophages (HP:0004311)5.83752941
5Myositis (HP:0100614)5.20193324
6Orchitis (HP:0100796)4.77200794
7Recurrent gram-negative bacterial infections (HP:0005420)4.75881482
8Retrobulbar optic neuritis (HP:0100654)4.75131898
9Optic neuritis (HP:0100653)4.75131898
10Stomatitis (HP:0010280)4.55670610
11Elevated erythrocyte sedimentation rate (HP:0003565)4.41675976
12Recurrent fungal infections (HP:0002841)4.06966566
13Recurrent skin infections (HP:0001581)3.96069159
14Recurrent cutaneous fungal infections (HP:0011370)3.75058167
15Chronic mucocutaneous candidiasis (HP:0002728)3.75058167
16Obstructive lung disease (HP:0006536)3.53397150
17Chronic obstructive pulmonary disease (HP:0006510)3.53397150
18Spontaneous hematomas (HP:0007420)3.53287611
19Keratoconjunctivitis (HP:0001096)3.47060436
20Encephalitis (HP:0002383)3.46838053
21Mediastinal lymphadenopathy (HP:0100721)3.45740242
22Meningitis (HP:0001287)3.42356282
23Keratoconjunctivitis sicca (HP:0001097)3.35081367
24Gastrointestinal infarctions (HP:0005244)3.28906000
25Prolonged bleeding time (HP:0003010)3.28155494
26Abnormality of glycolipid metabolism (HP:0010969)3.11070311
27Abnormality of liposaccharide metabolism (HP:0010968)3.11070311
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.11070311
29Abnormal delayed hypersensitivity skin test (HP:0002963)3.07495423
30Gingivitis (HP:0000230)3.05681941
31Urticaria (HP:0001025)2.96508586
32Chest pain (HP:0100749)2.91583719
33Vasculitis (HP:0002633)2.89781497
34Gingival bleeding (HP:0000225)2.84852798
35Pulmonary infiltrates (HP:0002113)2.79589839
36Hemoptysis (HP:0002105)2.79060206
37Arterial thrombosis (HP:0004420)2.75895757
38Episodic fever (HP:0001954)2.72631505
39Leukocytosis (HP:0001974)2.70247542
40T lymphocytopenia (HP:0005403)2.68815894
41Pustule (HP:0200039)2.67357473
42Hypochromic microcytic anemia (HP:0004840)2.65190617
43Recurrent viral infections (HP:0004429)2.59997623
44Amyloidosis (HP:0011034)2.57542543
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.56256244
46Epistaxis (HP:0000421)2.52014360
47Increased IgE level (HP:0003212)2.51529349
48Abnormality of T cell number (HP:0011839)2.48042953
49Panhypogammaglobulinemia (HP:0003139)2.45849770
50Pulmonary embolism (HP:0002204)2.44559266
51Increased cerebral lipofuscin (HP:0011813)2.41661310
52Loss of speech (HP:0002371)2.37830401
53Anorexia (HP:0002039)2.34094185
54Malnutrition (HP:0004395)2.31484931
55Osteomyelitis (HP:0002754)2.31115638
56Vertigo (HP:0002321)2.30059366
57Increased IgM level (HP:0003496)2.29263999
58Hypochromic anemia (HP:0001931)2.26395682
59Hematochezia (HP:0002573)2.22675110
60Absent rod-and cone-mediated responses on ERG (HP:0007688)2.22456153
61Abnormality of T cells (HP:0002843)2.19756295
62Hemiplegia (HP:0002301)2.15992430
63Keratitis (HP:0000491)2.13679452
64Inflammation of the large intestine (HP:0002037)2.13337096
65Abnormality of the columella (HP:0009929)2.12727382
66Cellulitis (HP:0100658)2.12669755
67Petechiae (HP:0000967)2.12068677
68Increased serum ferritin (HP:0003281)2.11575681
69Purpura (HP:0000979)2.10058502
70Gastrointestinal inflammation (HP:0004386)2.09645401
71Agitation (HP:0000713)2.08271658
72Peritonitis (HP:0002586)2.05575575
73Chronic otitis media (HP:0000389)2.00768134
74Granulocytopenia (HP:0001913)2.00058797
75Gangrene (HP:0100758)1.97387350
76Microcytic anemia (HP:0001935)1.97009624
77Dysostosis multiplex (HP:0000943)1.95199622
78Eosinophilia (HP:0001880)1.94842186
79Amaurosis fugax (HP:0100576)1.92956789
80Abnormality of iron homeostasis (HP:0011031)1.89961127
81Abnormality of the pleura (HP:0002103)1.89375552
82Thrombocytosis (HP:0001894)1.88095786
83Sepsis (HP:0100806)1.85475137
84Porencephaly (HP:0002132)1.84198279
85Polyneuropathy (HP:0001271)1.82172345
86Premature loss of primary teeth (HP:0006323)1.80835881
87Toxemia of pregnancy (HP:0100603)1.79852262
88Lymphopenia (HP:0001888)1.78385825
89Abnormality of T cell physiology (HP:0011840)1.77880672
90Increased neuronal autofluorescent lipopigment (HP:0002074)1.77493405
91Ventricular fibrillation (HP:0001663)1.77157419
92Memory impairment (HP:0002354)1.75961875
93Abnormality of the prostate (HP:0008775)1.75348890
94Disinhibition (HP:0000734)1.74409143
95Autoimmune thrombocytopenia (HP:0001973)1.71615383
96Glomerulopathy (HP:0100820)1.70774911
97Abnormality of the vasculature of the conjunctiva (HP:0008054)1.69764863
98Abnormal platelet volume (HP:0011876)1.68494245
99Cheilitis (HP:0100825)1.67971694
100Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67951980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.19933126
2MAP4K13.38913914
3BLK3.38913381
4MAP3K133.28521864
5TAOK32.92319417
6CSK2.75861416
7MAP3K92.66376642
8FES2.58488642
9TYK22.49064036
10TNK22.38207493
11MAP2K32.13759294
12BTK2.06108854
13ZAP701.92268192
14IRAK41.92211477
15ARAF1.83553578
16CSF1R1.82589337
17SYK1.71815811
18PRPF4B1.71387369
19TXK1.69926544
20TEC1.66783373
21HCK1.60947977
22FGR1.57978679
23GRK61.54927397
24MAP3K31.54281508
25LYN1.50485582
26KSR21.49910544
27KIT1.49025620
28ITK1.44545325
29JAK31.40349358
30MOS1.32470139
31EPHB11.30766461
32MARK31.28568124
33PDK11.24428262
34IKBKE1.22244243
35LCK1.19830421
36STK101.19710685
37MAP3K141.16219421
38ERN11.08147250
39MAP3K111.08106670
40JAK21.06507335
41TBK11.06452017
42CDK191.06261072
43YES11.02999639
44STK241.02707201
45MAP3K11.00452617
46IKBKB0.94035987
47MATK0.92214462
48TESK20.91321838
49TGFBR20.89555560
50BMPR20.86023942
51PDPK10.85600781
52PRKCQ0.83892471
53LRRK20.82407490
54RAF10.81973178
55JAK10.81630671
56NEK60.80168463
57PRKD20.77124597
58CAMKK10.73736275
59GRK70.71969354
60STK110.71842795
61PIK3CG0.71120798
62KDR0.70003793
63CAMKK20.69586581
64FYN0.67996793
65PIM10.66187551
66CDK90.64139283
67SIK30.61004070
68KSR10.58703026
69IRAK10.58512671
70MAP3K50.56232001
71PTK60.54948366
72TAOK10.54477007
73MAP3K70.51624333
74ABL10.50841783
75GRK10.49054052
76OXSR10.48994791
77MAPK70.48125453
78IRAK20.46624485
79PTK2B0.46372338
80MST40.43261780
81BRAF0.42986135
82MARK20.41722739
83DAPK20.41148153
84RPS6KA60.40748649
85RPS6KL10.37693059
86RPS6KC10.37693059
87PRKCZ0.36082888
88MELK0.35364016
89MAP2K40.35155366
90FGFR30.34032614
91PRKD10.33101361
92SGK30.32587807
93TAOK20.32463563
94NEK90.32376346
95MAPKAPK20.32229658
96FRK0.32072265
97MAP3K80.31999134
98ADRBK10.29787034
99MAPKAPK30.29172144
100PAK10.28821081

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.11373162
2Leishmaniasis_Homo sapiens_hsa051402.91206411
3Osteoclast differentiation_Homo sapiens_hsa043802.76895078
4Allograft rejection_Homo sapiens_hsa053302.56949066
5Graft-versus-host disease_Homo sapiens_hsa053322.53484929
6Autoimmune thyroid disease_Homo sapiens_hsa053202.42645204
7Primary immunodeficiency_Homo sapiens_hsa053402.12967225
8Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.12222094
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11913533
10B cell receptor signaling pathway_Homo sapiens_hsa046622.06461052
11Tuberculosis_Homo sapiens_hsa051522.05452240
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.91237584
13Hematopoietic cell lineage_Homo sapiens_hsa046401.91003974
14Type I diabetes mellitus_Homo sapiens_hsa049401.89394793
15Antigen processing and presentation_Homo sapiens_hsa046121.82043525
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.80415634
17Asthma_Homo sapiens_hsa053101.80378911
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.78989283
19Toll-like receptor signaling pathway_Homo sapiens_hsa046201.75723221
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.69965791
21Malaria_Homo sapiens_hsa051441.62341641
22Phagosome_Homo sapiens_hsa041451.59877874
23T cell receptor signaling pathway_Homo sapiens_hsa046601.56284435
24Chemokine signaling pathway_Homo sapiens_hsa040621.51809994
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.51533443
26Other glycan degradation_Homo sapiens_hsa005111.47154574
27Measles_Homo sapiens_hsa051621.45747385
28Herpes simplex infection_Homo sapiens_hsa051681.38102981
29Viral myocarditis_Homo sapiens_hsa054161.37323390
30Legionellosis_Homo sapiens_hsa051341.27451201
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.27053823
32Toxoplasmosis_Homo sapiens_hsa051451.23187037
33Rheumatoid arthritis_Homo sapiens_hsa053231.21234462
34Influenza A_Homo sapiens_hsa051641.19963555
35Dorso-ventral axis formation_Homo sapiens_hsa043201.17913639
36Platelet activation_Homo sapiens_hsa046111.11914796
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.11571580
38Shigellosis_Homo sapiens_hsa051311.08553329
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.07992658
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04629138
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99869433
42SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97752796
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95823463
44Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.94959789
45Acute myeloid leukemia_Homo sapiens_hsa052210.94873147
46Pertussis_Homo sapiens_hsa051330.93377753
47Lysosome_Homo sapiens_hsa041420.91313006
48African trypanosomiasis_Homo sapiens_hsa051430.90909623
49Hepatitis B_Homo sapiens_hsa051610.88875723
50Salmonella infection_Homo sapiens_hsa051320.87894926
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86744057
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.84044883
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.83213283
54Non-small cell lung cancer_Homo sapiens_hsa052230.76992498
55Regulation of autophagy_Homo sapiens_hsa041400.75972441
56Type II diabetes mellitus_Homo sapiens_hsa049300.75787297
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73308735
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71744879
59TNF signaling pathway_Homo sapiens_hsa046680.71505875
60Choline metabolism in cancer_Homo sapiens_hsa052310.69384447
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69133594
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.66691791
63Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66277774
64Phototransduction_Homo sapiens_hsa047440.64218110
65Ovarian steroidogenesis_Homo sapiens_hsa049130.64064601
66Olfactory transduction_Homo sapiens_hsa047400.63583429
67p53 signaling pathway_Homo sapiens_hsa041150.62768510
68Endocytosis_Homo sapiens_hsa041440.62714754
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60194469
70FoxO signaling pathway_Homo sapiens_hsa040680.59719206
71Phospholipase D signaling pathway_Homo sapiens_hsa040720.58373821
72Morphine addiction_Homo sapiens_hsa050320.57718024
73Notch signaling pathway_Homo sapiens_hsa043300.56761616
74Hepatitis C_Homo sapiens_hsa051600.55849701
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54136851
76mTOR signaling pathway_Homo sapiens_hsa041500.49493217
77Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.48582730
78Prolactin signaling pathway_Homo sapiens_hsa049170.48544448
79Viral carcinogenesis_Homo sapiens_hsa052030.48427850
80Apoptosis_Homo sapiens_hsa042100.47741714
81Glycerolipid metabolism_Homo sapiens_hsa005610.47494016
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.45908273
83Epstein-Barr virus infection_Homo sapiens_hsa051690.45713553
84Insulin resistance_Homo sapiens_hsa049310.45629676
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.45402402
86Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44640391
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43257028
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42920139
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41744930
90HTLV-I infection_Homo sapiens_hsa051660.41265582
91MAPK signaling pathway_Homo sapiens_hsa040100.41170111
92Pancreatic cancer_Homo sapiens_hsa052120.41076968
93GnRH signaling pathway_Homo sapiens_hsa049120.40991207
94Amoebiasis_Homo sapiens_hsa051460.40784776
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.39579686
96VEGF signaling pathway_Homo sapiens_hsa043700.39422862
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38210785
98Caffeine metabolism_Homo sapiens_hsa002320.37280951
99Rap1 signaling pathway_Homo sapiens_hsa040150.36202800
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35311347

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