ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	replication fork processing (GO:0031297)	5.85320238
2	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	4.60614651
3	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.47653190
4	female gonad development (GO:0008585)	4.39404393
5	neurotransmitter catabolic process (GO:0042135)	4.16828638
6	kinetochore organization (GO:0051383)	4.11636055
7	negative regulation of DNA-dependent DNA replication (GO:2000104)	3.98056916
8	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	3.94721218
9	kinetochore assembly (GO:0051382)	3.91134489
10	regulation of centriole replication (GO:0046599)	3.84720103
11	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.84490153
12	regulation of mitotic spindle checkpoint (GO:1903504)	3.84490153
13	protein K6-linked ubiquitination (GO:0085020)	3.82199955
14	DNA replication-dependent nucleosome assembly (GO:0006335)	3.69665993
15	DNA replication-dependent nucleosome organization (GO:0034723)	3.69665993
16	chromatin remodeling at centromere (GO:0031055)	3.65959118
17	mitotic metaphase plate congression (GO:0007080)	3.52848834
18	centriole replication (GO:0007099)	3.49227395
19	double-strand break repair via homologous recombination (GO:0000724)	3.48194522
20	meiotic chromosome segregation (GO:0045132)	3.47800886
21	recombinational repair (GO:0000725)	3.45639163
22	regulation of Wnt signaling pathway involved in heart development (GO:0003307)	3.43913495
23	CENP-A containing nucleosome assembly (GO:0034080)	3.39823487
24	metaphase plate congression (GO:0051310)	3.36949118
25	DNA double-strand break processing (GO:0000729)	3.34133621
26	mitotic sister chromatid cohesion (GO:0007064)	3.29696067
27	endoderm formation (GO:0001706)	3.23917376
28	postreplication repair (GO:0006301)	3.21306222
29	neural tube formation (GO:0001841)	3.19929505
30	regulation of meiosis I (GO:0060631)	3.19715536
31	histone exchange (GO:0043486)	3.15252454
32	protein prenylation (GO:0018342)	3.12746276
33	prenylation (GO:0097354)	3.12746276
34	glyoxylate metabolic process (GO:0046487)	3.06985597
35	mitotic sister chromatid segregation (GO:0000070)	3.06811646
36	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.05750082
37	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.05750082
38	regulation of translation, ncRNA-mediated (GO:0045974)	3.05750082
39	cellular response to cholesterol (GO:0071397)	3.04976591
40	histone H2A acetylation (GO:0043968)	3.04240683
41	nuclear pore complex assembly (GO:0051292)	3.01857446
42	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	2.99015395
43	cellular response to sterol (GO:0036315)	2.98912568
44	kynurenine metabolic process (GO:0070189)	2.95753786
45	telomere maintenance via telomerase (GO:0007004)	2.95331591
46	microtubule depolymerization (GO:0007019)	2.94099686
47	tryptophan catabolic process (GO:0006569)	2.94053090
48	indole-containing compound catabolic process (GO:0042436)	2.94053090
49	indolalkylamine catabolic process (GO:0046218)	2.94053090
50	microtubule polymerization or depolymerization (GO:0031109)	2.90878535
51	DNA-dependent DNA replication (GO:0006261)	2.90317299
52	mitochondrial DNA replication (GO:0006264)	2.90113434
53	protein localization to kinetochore (GO:0034501)	2.90056792
54	protein neddylation (GO:0045116)	2.89371744
55	dorsal/ventral axis specification (GO:0009950)	2.89354193
56	regulation of centrosome duplication (GO:0010824)	2.89043151
57	nucleotide transmembrane transport (GO:1901679)	2.86390806
58	mitotic nuclear envelope disassembly (GO:0007077)	2.84269741
59	somite development (GO:0061053)	2.83687331
60	DNA strand renaturation (GO:0000733)	2.83132393
61	DNA replication checkpoint (GO:0000076)	2.82908874
62	sister chromatid segregation (GO:0000819)	2.82198928
63	protein polyglutamylation (GO:0018095)	2.81532174
64	nuclear pore organization (GO:0006999)	2.79961372
65	rRNA methylation (GO:0031167)	2.78598350
66	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.76076758
67	nuclear envelope disassembly (GO:0051081)	2.72409350
68	membrane disassembly (GO:0030397)	2.72409350
69	cornea development in camera-type eye (GO:0061303)	2.72172800
70	behavioral response to nicotine (GO:0035095)	2.72065300
71	regulation of DNA endoreduplication (GO:0032875)	2.71938366
72	DNA replication-independent nucleosome assembly (GO:0006336)	2.71678349
73	DNA replication-independent nucleosome organization (GO:0034724)	2.71678349
74	microtubule severing (GO:0051013)	2.69736540
75	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.69676732
76	regulation of translational termination (GO:0006449)	2.69171366
77	regulation of centrosome cycle (GO:0046605)	2.68296018
78	pseudouridine synthesis (GO:0001522)	2.68105699
79	ncRNA catabolic process (GO:0034661)	2.67688837
80	rRNA catabolic process (GO:0016075)	2.67228706
81	tRNA processing (GO:0008033)	2.65796121
82	rRNA modification (GO:0000154)	2.62274843
83	inositol phosphate catabolic process (GO:0071545)	2.62016573
84	telomere maintenance via recombination (GO:0000722)	2.61517381
85	mitotic recombination (GO:0006312)	2.61323380
86	establishment of chromosome localization (GO:0051303)	2.60944700
87	protein K11-linked deubiquitination (GO:0035871)	2.60085660
88	regulation of telomere maintenance (GO:0032204)	2.59555973
89	mitotic G2/M transition checkpoint (GO:0044818)	2.58774321
90	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.53389292
91	olfactory bulb development (GO:0021772)	2.53247437
92	regulation of sister chromatid cohesion (GO:0007063)	2.52944318
93	regulation of spindle checkpoint (GO:0090231)	2.51363087
94	maturation of 5.8S rRNA (GO:0000460)	2.50748155
95	DNA strand elongation involved in DNA replication (GO:0006271)	2.50319517
96	reciprocal meiotic recombination (GO:0007131)	2.48045702
97	reciprocal DNA recombination (GO:0035825)	2.48045702
98	mRNA cleavage (GO:0006379)	2.47829987
99	axoneme assembly (GO:0035082)	2.46345094
100	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.45902131

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E2F7_22180533_ChIP-Seq_HELA_Human	4.65520696
2	SALL1_21062744_ChIP-ChIP_HESCs_Human	4.51357200
3	E2F4_17652178_ChIP-ChIP_JURKAT_Human	4.07009209
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.69280032
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.52337165
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.44569254
7	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.23053331
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.17214543
9	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.83612904
10	EWS_26573619_Chip-Seq_HEK293_Human	2.67492271
11	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.65091112
12	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.59547652
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.53210215
14	FUS_26573619_Chip-Seq_HEK293_Human	2.43066741
15	ZNF274_21170338_ChIP-Seq_K562_Hela	2.35895466
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.27428982
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.24928796
18	GBX2_23144817_ChIP-Seq_PC3_Human	2.23968340
19	ELK1_19687146_ChIP-ChIP_HELA_Human	2.21495041
20	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.19498522
21	TP63_19390658_ChIP-ChIP_HaCaT_Human	2.14796044
22	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.13135546
23	VDR_22108803_ChIP-Seq_LS180_Human	2.12363811
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.09820495
25	IRF1_19129219_ChIP-ChIP_H3396_Human	2.06415905
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99944520
27	P300_19829295_ChIP-Seq_ESCs_Human	1.95115730
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.93430943
29	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.92376129
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.80269513
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.69915571
32	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.67807955
33	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.67430862
34	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66970475
35	VDR_23849224_ChIP-Seq_CD4+_Human	1.65396940
36	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.64898910
37	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.62205844
38	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.60091573
39	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56791730
40	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.55805597
41	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.53603581
42	E2F1_21310950_ChIP-Seq_MCF-7_Human	1.52324116
43	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.47931875
44	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46696239
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46394028
46	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.45284573
47	BCAT_22108803_ChIP-Seq_LS180_Human	1.40939899
48	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.33725878
49	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.31435971
50	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30623167
51	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28885071
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.27626228
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27584739
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.24767874
55	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.22931872
56	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.21898312
57	TAF15_26573619_Chip-Seq_HEK293_Human	1.20450887
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.20070425
59	TCF4_22108803_ChIP-Seq_LS180_Human	1.19203465
60	STAT3_23295773_ChIP-Seq_U87_Human	1.17242954
61	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.16953256
62	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15982443
63	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.15838353
64	AR_25329375_ChIP-Seq_VCAP_Human	1.15359516
65	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.12854383
66	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.11691280
67	NANOG_16153702_ChIP-ChIP_HESCs_Human	1.11370777
68	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.11037074
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.10920600
70	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.10440471
71	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.07847840
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06561160
73	SMAD4_21799915_ChIP-Seq_A2780_Human	1.05564290
74	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.04737182
75	ER_23166858_ChIP-Seq_MCF-7_Human	1.02745010
76	GABP_19822575_ChIP-Seq_HepG2_Human	1.01952089
77	TTF2_22483619_ChIP-Seq_HELA_Human	1.00788485
78	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.00423929
79	MYC_19030024_ChIP-ChIP_MESCs_Mouse	0.99092504
80	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.98349272
81	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.96913102
82	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.96748024
83	TP53_22573176_ChIP-Seq_HFKS_Human	0.96715133
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.95741306
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94085026
86	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.94042908
87	IGF1R_20145208_ChIP-Seq_DFB_Human	0.93876625
88	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.92171252
89	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.91860678
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.91004384
91	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.90940198
92	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.90734354
93	SOX9_26525672_Chip-Seq_HEART_Mouse	0.90493324
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.89421806
95	TCF4_23295773_ChIP-Seq_U87_Human	0.89333653
96	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.87525992
97	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	0.87001315
98	E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.86782842
99	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.86537942
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.86471229

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.11759250
2	MP0008057_abnormal_DNA_replication	3.99238394
3	MP0003890_abnormal_embryonic-extraembry	3.67975385
4	MP0003195_calcinosis	3.53310123
5	MP0010094_abnormal_chromosome_stability	3.33269138
6	MP0003787_abnormal_imprinting	3.26585304
7	MP0003693_abnormal_embryo_hatching	3.06232817
8	MP0008058_abnormal_DNA_repair	2.80814385
9	MP0006054_spinal_hemorrhage	2.37037039
10	MP0003121_genomic_imprinting	2.34837190
11	MP0003111_abnormal_nucleus_morphology	2.31720109
12	MP0003077_abnormal_cell_cycle	2.27785319
13	MP0002736_abnormal_nociception_after	2.12871520
14	MP0006292_abnormal_olfactory_placode	2.07147033
15	MP0010030_abnormal_orbit_morphology	1.98235033
16	MP0004142_abnormal_muscle_tone	1.81344873
17	MP0005551_abnormal_eye_electrophysiolog	1.79283498
18	MP0004957_abnormal_blastocyst_morpholog	1.71387192
19	MP0003122_maternal_imprinting	1.66534176
20	MP0003941_abnormal_skin_development	1.66034060
21	MP0004742_abnormal_vestibular_system	1.61263094
22	MP0003718_maternal_effect	1.51691668
23	MP0006072_abnormal_retinal_apoptosis	1.51610184
24	MP0003937_abnormal_limbs/digits/tail_de	1.45049663
25	MP0008932_abnormal_embryonic_tissue	1.44181626
26	MP0001293_anophthalmia	1.42462065
27	MP0003646_muscle_fatigue	1.37016387
28	MP0002282_abnormal_trachea_morphology	1.34411086
29	MP0005253_abnormal_eye_physiology	1.33588133
30	MP0005623_abnormal_meninges_morphology	1.30638700
31	MP0002751_abnormal_autonomic_nervous	1.30081030
32	MP0002638_abnormal_pupillary_reflex	1.29218059
33	MP0003786_premature_aging	1.28587390
34	MP0003119_abnormal_digestive_system	1.26268871
35	MP0000427_abnormal_hair_cycle	1.24991805
36	MP0001919_abnormal_reproductive_system	1.24767992
37	MP0000049_abnormal_middle_ear	1.24431685
38	MP0004147_increased_porphyrin_level	1.21548845
39	MP0003136_yellow_coat_color	1.21000346
40	MP0008995_early_reproductive_senescence	1.19846394
41	MP0001929_abnormal_gametogenesis	1.18173435
42	MP0006035_abnormal_mitochondrial_morpho	1.17058583
43	MP0008007_abnormal_cellular_replicative	1.15213189
44	MP0002233_abnormal_nose_morphology	1.14836676
45	MP0001485_abnormal_pinna_reflex	1.14557810
46	MP0002210_abnormal_sex_determination	1.11793728
47	MP0003123_paternal_imprinting	1.08885376
48	MP0001286_abnormal_eye_development	1.06999423
49	MP0005367_renal/urinary_system_phenotyp	1.06472153
50	MP0000516_abnormal_urinary_system	1.06472153
51	MP0001968_abnormal_touch/_nociception	1.05753524
52	MP0001119_abnormal_female_reproductive	1.03447144
53	MP0005499_abnormal_olfactory_system	1.01731490
54	MP0005394_taste/olfaction_phenotype	1.01731490
55	MP0000647_abnormal_sebaceous_gland	1.01127339
56	MP0005391_vision/eye_phenotype	1.00922526
57	MP0002249_abnormal_larynx_morphology	0.99183087
58	MP0002734_abnormal_mechanical_nocicepti	0.98621094
59	MP0002234_abnormal_pharynx_morphology	0.94729388
60	MP0004197_abnormal_fetal_growth/weight/	0.93378033
61	MP0003567_abnormal_fetal_cardiomyocyte	0.92663688
62	MP0000778_abnormal_nervous_system	0.92563904
63	MP0001145_abnormal_male_reproductive	0.91899939
64	MP0002111_abnormal_tail_morphology	0.91282857
65	MP0005195_abnormal_posterior_eye	0.90864835
66	MP0008789_abnormal_olfactory_epithelium	0.90675572
67	MP0003755_abnormal_palate_morphology	0.89955039
68	MP0005395_other_phenotype	0.88378448
69	MP0001486_abnormal_startle_reflex	0.87984970
70	MP0000653_abnormal_sex_gland	0.86843990
71	MP0009250_abnormal_appendicular_skeleto	0.85082670
72	MP0000490_abnormal_crypts_of	0.82873698
73	MP0003943_abnormal_hepatobiliary_system	0.82229795
74	MP0002272_abnormal_nervous_system	0.81953217
75	MP0002084_abnormal_developmental_patter	0.80130210
76	MP0005389_reproductive_system_phenotype	0.79466020
77	MP0005410_abnormal_fertilization	0.79243214
78	MP0001672_abnormal_embryogenesis/_devel	0.78907317
79	MP0005380_embryogenesis_phenotype	0.78907317
80	MP0006276_abnormal_autonomic_nervous	0.78144488
81	MP0000569_abnormal_digit_pigmentation	0.76617699
82	MP0002752_abnormal_somatic_nervous	0.76136191
83	MP0001324_abnormal_eye_pigmentation	0.75413524
84	MP0003698_abnormal_male_reproductive	0.75397691
85	MP0009046_muscle_twitch	0.74300787
86	MP0009703_decreased_birth_body	0.72991225
87	MP0001697_abnormal_embryo_size	0.72225471
88	MP0001501_abnormal_sleep_pattern	0.70921737
89	MP0000631_abnormal_neuroendocrine_gland	0.70836560
90	MP0002184_abnormal_innervation	0.70101773
91	MP0002088_abnormal_embryonic_growth/wei	0.70071562
92	MP0002109_abnormal_limb_morphology	0.69639930
93	MP0003984_embryonic_growth_retardation	0.69380295
94	MP0004808_abnormal_hematopoietic_stem	0.67169217
95	MP0005310_abnormal_salivary_gland	0.67102576
96	MP0005266_abnormal_metabolism	0.66904496
97	MP0002067_abnormal_sensory_capabilities	0.66607430
98	MP0010307_abnormal_tumor_latency	0.66180579
99	MP0003385_abnormal_body_wall	0.65784731
100	MP0003936_abnormal_reproductive_system	0.65690088

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of the labia minora (HP:0012880)	4.56587874
2	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.62132933
3	Chromsome breakage (HP:0040012)	3.47692364
4	Abnormality of the ileum (HP:0001549)	3.47268420
5	Hepatoblastoma (HP:0002884)	3.41275198
6	Meckel diverticulum (HP:0002245)	3.32689045
7	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.31953299
8	Abnormality of chromosome stability (HP:0003220)	3.26252173
9	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.10324153
10	Abnormality of alanine metabolism (HP:0010916)	3.10324153
11	Hyperalaninemia (HP:0003348)	3.10324153
12	Volvulus (HP:0002580)	3.07811480
13	Abnormality of the labia majora (HP:0012881)	2.95514350
14	Abnormality of midbrain morphology (HP:0002418)	2.93581010
15	Molar tooth sign on MRI (HP:0002419)	2.93581010
16	Hypoplastic labia majora (HP:0000059)	2.89730887
17	Abnormality of the preputium (HP:0100587)	2.86280396
18	Clubbing of toes (HP:0100760)	2.76595050
19	Nephronophthisis (HP:0000090)	2.74759499
20	Neoplasm of the adrenal cortex (HP:0100641)	2.65589476
21	Hyperventilation (HP:0002883)	2.59778351
22	Chronic hepatic failure (HP:0100626)	2.59350729
23	Labial hypoplasia (HP:0000066)	2.58613050
24	Duodenal stenosis (HP:0100867)	2.58533278
25	Small intestinal stenosis (HP:0012848)	2.58533278
26	Hypoplastic female external genitalia (HP:0012815)	2.56436838
27	Embryonal renal neoplasm (HP:0011794)	2.51851474
28	True hermaphroditism (HP:0010459)	2.48469723
29	Pancreatic cysts (HP:0001737)	2.48304828
30	Multiple enchondromatosis (HP:0005701)	2.45647020
31	Adactyly (HP:0009776)	2.45099118
32	Aplasia/Hypoplasia of the sternum (HP:0006714)	2.44357112
33	Duplicated collecting system (HP:0000081)	2.44288561
34	Sloping forehead (HP:0000340)	2.41558299
35	Ectopic kidney (HP:0000086)	2.38455036
36	Protruding tongue (HP:0010808)	2.37774808
37	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.36580715
38	Absent radius (HP:0003974)	2.29555771
39	Abnormality of the duodenum (HP:0002246)	2.29259334
40	Abnormality of the parathyroid morphology (HP:0011766)	2.29093716
41	Absent speech (HP:0001344)	2.29059132
42	Neoplasm of the adrenal gland (HP:0100631)	2.28531058
43	Patellar aplasia (HP:0006443)	2.28505230
44	Reticulocytopenia (HP:0001896)	2.24622214
45	Glioma (HP:0009733)	2.24500537
46	Abnormal lung lobation (HP:0002101)	2.23922356
47	Tubular atrophy (HP:0000092)	2.23210290
48	Aplasia/Hypoplasia of the patella (HP:0006498)	2.21424904
49	Abnormality of the carotid arteries (HP:0005344)	2.20496856
50	Bifid tongue (HP:0010297)	2.18321769
51	Dyschromatopsia (HP:0007641)	2.18315958
52	Abnormality of the renal medulla (HP:0100957)	2.18270178
53	Aplasia involving forearm bones (HP:0009822)	2.17157471
54	Absent forearm bone (HP:0003953)	2.17157471
55	Birth length less than 3rd percentile (HP:0003561)	2.16292611
56	Tubulointerstitial nephritis (HP:0001970)	2.15927766
57	Abnormality of the renal collecting system (HP:0004742)	2.13730944
58	Abnormal pancreas size (HP:0012094)	2.12129163
59	Horseshoe kidney (HP:0000085)	2.08251510
60	Short 1st metacarpal (HP:0010034)	2.07938799
61	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.07938799
62	Long clavicles (HP:0000890)	2.06960218
63	Sensory axonal neuropathy (HP:0003390)	2.06319593
64	Lissencephaly (HP:0001339)	2.05949136
65	Limb hypertonia (HP:0002509)	2.05774649
66	Fair hair (HP:0002286)	2.02644671
67	Progressive inability to walk (HP:0002505)	2.02428897
68	Acute necrotizing encephalopathy (HP:0006965)	1.99488386
69	Acute encephalopathy (HP:0006846)	1.98064762
70	Tented upper lip vermilion (HP:0010804)	1.97798369
71	Anophthalmia (HP:0000528)	1.94460726
72	Intestinal atresia (HP:0011100)	1.94312733
73	Triphalangeal thumb (HP:0001199)	1.93819430
74	Colon cancer (HP:0003003)	1.92599495
75	Narrow forehead (HP:0000341)	1.90569063
76	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.89823620
77	Bicornuate uterus (HP:0000813)	1.89715662
78	Myelodysplasia (HP:0002863)	1.87508327
79	Pancreatic fibrosis (HP:0100732)	1.87472784
80	Short tibia (HP:0005736)	1.87422732
81	Astrocytoma (HP:0009592)	1.86807262
82	Abnormality of the astrocytes (HP:0100707)	1.86807262
83	Oligodactyly (hands) (HP:0001180)	1.83569764
84	Abnormality of the labia (HP:0000058)	1.83353711
85	Dandy-Walker malformation (HP:0001305)	1.83239740
86	Oligohydramnios (HP:0001562)	1.83174149
87	Broad-based gait (HP:0002136)	1.83098003
88	Congenital stationary night blindness (HP:0007642)	1.82577107
89	Abnormality of serum amino acid levels (HP:0003112)	1.82279639
90	Abnormality of the 1st metacarpal (HP:0010009)	1.79941222
91	Exotropia (HP:0000577)	1.78601616
92	Astigmatism (HP:0000483)	1.77975055
93	Short thumb (HP:0009778)	1.76949630
94	Ependymoma (HP:0002888)	1.76804711
95	Nephroblastoma (Wilms tumor) (HP:0002667)	1.76227624
96	Shawl scrotum (HP:0000049)	1.73685318
97	Enlarged kidneys (HP:0000105)	1.72865833
98	Abnormal mitochondria in muscle tissue (HP:0008316)	1.72732271
99	Increased CSF lactate (HP:0002490)	1.72580756
100	Progressive macrocephaly (HP:0004481)	1.72310170

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	4.26837704
2	ACVR1B	3.96167226
3	WNK3	3.53315120
4	BMPR1B	3.33234971
5	NUAK1	2.91066922
6	PDK2	2.88657734
7	MKNK2	2.71324355
8	PLK4	2.43833384
9	TRIM28	2.43251691
10	TSSK6	2.34133334
11	MAP4K2	2.28886515
12	STK16	2.20073262
13	FRK	2.19563187
14	PINK1	2.03885033
15	CASK	1.99436235
16	TLK1	1.98040337
17	TNIK	1.91339131
18	SRPK1	1.85522545
19	MAPK13	1.80442491
20	BRSK2	1.73033242
21	BUB1	1.70436926
22	MKNK1	1.65790379
23	WEE1	1.63748111
24	MAP3K11	1.61608684
25	CDC7	1.55630152
26	BRD4	1.54566544
27	WNK4	1.42733076
28	TGFBR1	1.39223613
29	AKT3	1.33067865
30	PLK3	1.26037330
31	CAMKK2	1.21633046
32	CSNK1G1	1.16639427
33	ERBB4	1.07648826
34	STK39	1.04121986
35	INSRR	1.03105918
36	VRK1	1.02797374
37	TTK	1.01926608
38	RAF1	0.96922975
39	MAP3K12	0.95999149
40	DMPK	0.95385163
41	MELK	0.94283726
42	ATR	0.94198917
43	PBK	0.90088846
44	PLK1	0.89938117
45	KSR1	0.85695641
46	PIM2	0.81259065
47	OXSR1	0.79348837
48	PAK3	0.78314120
49	TAF1	0.77422332
50	RPS6KB2	0.76545367
51	PLK2	0.75503812
52	PNCK	0.69611249
53	GRK1	0.69502990
54	EPHB2	0.68942603
55	CSNK1G2	0.65857306
56	CDK19	0.65320565
57	CHEK2	0.64872434
58	RPS6KA5	0.64772178
59	ERBB3	0.64627390
60	PKN1	0.64362954
61	MAPKAPK3	0.64207630
62	PIM1	0.64195411
63	MINK1	0.62437223
64	SIK3	0.60381796
65	RPS6KA4	0.59611611
66	EIF2AK3	0.58970237
67	ADRBK1	0.57150672
68	CAMK1D	0.56870930
69	CSNK1G3	0.56371189
70	STK4	0.55593860
71	AURKB	0.55398338
72	CSNK1A1L	0.53780846
73	ADRBK2	0.50737908
74	CAMK1G	0.49991077
75	ATM	0.49296489
76	CHEK1	0.48381638
77	CCNB1	0.46400863
78	BRSK1	0.45500797
79	DYRK2	0.42927404
80	NEK1	0.42540318
81	TXK	0.41781746
82	IRAK2	0.37808433
83	STK10	0.37283916
84	AKT2	0.36557063
85	NLK	0.36439091
86	FLT3	0.33574207
87	MAP2K7	0.33344406
88	CDK8	0.32768570
89	PRKCQ	0.32240380
90	CSNK1A1	0.32181487
91	CDK1	0.31291679
92	CAMK2D	0.31199801
93	NEK6	0.30023577
94	BCR	0.29008713
95	CAMK2A	0.28432713
96	PRKCI	0.26208706
97	TIE1	0.26001549
98	PRKACA	0.25780023
99	PRKG1	0.25764004
100	CAMK2B	0.25009780

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.11494411
2	Fanconi anemia pathway_Homo sapiens_hsa03460	3.04289215
3	Homologous recombination_Homo sapiens_hsa03440	3.02070593
4	Non-homologous end-joining_Homo sapiens_hsa03450	2.99832975
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.70845732
6	Basal transcription factors_Homo sapiens_hsa03022	2.55056328
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.51270954
8	DNA replication_Homo sapiens_hsa03030	2.47255564
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.44957156
10	RNA polymerase_Homo sapiens_hsa03020	2.40063006
11	Mismatch repair_Homo sapiens_hsa03430	2.33810808
12	RNA degradation_Homo sapiens_hsa03018	2.24264747
13	Cell cycle_Homo sapiens_hsa04110	2.04530172
14	Protein export_Homo sapiens_hsa03060	2.02413866
15	Systemic lupus erythematosus_Homo sapiens_hsa05322	2.01965319
16	Proteasome_Homo sapiens_hsa03050	2.01383540
17	Butanoate metabolism_Homo sapiens_hsa00650	1.99991588
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.95480079
19	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.94521998
20	RNA transport_Homo sapiens_hsa03013	1.84776562
21	Phototransduction_Homo sapiens_hsa04744	1.72265472
22	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.69608993
23	Alcoholism_Homo sapiens_hsa05034	1.60074128
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.58694054
25	Nitrogen metabolism_Homo sapiens_hsa00910	1.53476753
26	Base excision repair_Homo sapiens_hsa03410	1.48590495
27	Lysine degradation_Homo sapiens_hsa00310	1.43451297
28	Purine metabolism_Homo sapiens_hsa00230	1.41447203
29	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.41197776
30	Caffeine metabolism_Homo sapiens_hsa00232	1.36728111
31	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.27960261
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.27275986
33	Sulfur relay system_Homo sapiens_hsa04122	1.25174674
34	Pyrimidine metabolism_Homo sapiens_hsa00240	1.24406567
35	Propanoate metabolism_Homo sapiens_hsa00640	1.23059751
36	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.16831183
37	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.13345416
38	p53 signaling pathway_Homo sapiens_hsa04115	1.12933858
39	Tryptophan metabolism_Homo sapiens_hsa00380	1.10337232
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09028452
41	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.08550091
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.05144968
43	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.03892230
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.03422432
45	Spliceosome_Homo sapiens_hsa03040	1.02907417
46	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.02851610
47	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.97887805
48	mRNA surveillance pathway_Homo sapiens_hsa03015	0.96688349
49	Fatty acid metabolism_Homo sapiens_hsa01212	0.92919949
50	One carbon pool by folate_Homo sapiens_hsa00670	0.88180895
51	Basal cell carcinoma_Homo sapiens_hsa05217	0.87363340
52	Hippo signaling pathway_Homo sapiens_hsa04390	0.82787989
53	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.82669161
54	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.82525073
55	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.81857600
56	Linoleic acid metabolism_Homo sapiens_hsa00591	0.80112418
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.79940371
58	Oocyte meiosis_Homo sapiens_hsa04114	0.79276900
59	Fatty acid degradation_Homo sapiens_hsa00071	0.78551772
60	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.78124117
61	Peroxisome_Homo sapiens_hsa04146	0.77841406
62	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.73273134
63	Nicotine addiction_Homo sapiens_hsa05033	0.70201411
64	Regulation of autophagy_Homo sapiens_hsa04140	0.68943230
65	Glutathione metabolism_Homo sapiens_hsa00480	0.67663483
66	Pyruvate metabolism_Homo sapiens_hsa00620	0.63195371
67	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.61379206
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.59903351
69	Morphine addiction_Homo sapiens_hsa05032	0.59384496
70	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.56955942
71	Parkinsons disease_Homo sapiens_hsa05012	0.56691985
72	Glycerolipid metabolism_Homo sapiens_hsa00561	0.56250892
73	Huntingtons disease_Homo sapiens_hsa05016	0.54936772
74	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.51876348
75	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50256086
76	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.49420500
77	Metabolic pathways_Homo sapiens_hsa01100	0.45542797
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.44706130
79	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.44199090
80	Oxidative phosphorylation_Homo sapiens_hsa00190	0.43931001
81	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42671855
82	Folate biosynthesis_Homo sapiens_hsa00790	0.40663585
83	Ribosome_Homo sapiens_hsa03010	0.39811907
84	Fatty acid elongation_Homo sapiens_hsa00062	0.39060150
85	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.38782555
86	Circadian rhythm_Homo sapiens_hsa04710	0.37564792
87	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35552727
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.35465009
89	Olfactory transduction_Homo sapiens_hsa04740	0.33810986
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.31338540
91	Wnt signaling pathway_Homo sapiens_hsa04310	0.29046811
92	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.28840987
93	Sulfur metabolism_Homo sapiens_hsa00920	0.27338786
94	MicroRNAs in cancer_Homo sapiens_hsa05206	0.27276245
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.26281432
96	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.24317365
97	Axon guidance_Homo sapiens_hsa04360	0.20769809
98	beta-Alanine metabolism_Homo sapiens_hsa00410	0.17447996
99	HTLV-I infection_Homo sapiens_hsa05166	0.16151501
100	Alzheimers disease_Homo sapiens_hsa05010	0.15432195

RPL7AP65

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »