ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.99148982
2	DNA deamination (GO:0045006)	6.64553372
3	cytidine deamination (GO:0009972)	6.30707651
4	cytidine metabolic process (GO:0046087)	6.30707651
5	cytidine catabolic process (GO:0006216)	6.30707651
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	5.91134485
7	pyrimidine ribonucleoside catabolic process (GO:0046133)	5.45820654
8	viral transcription (GO:0019083)	5.06008000
9	translational termination (GO:0006415)	4.80468830
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.77990398
11	translational elongation (GO:0006414)	4.45737526
12	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.29395966
13	ribosomal small subunit biogenesis (GO:0042274)	4.29003426
14	cotranslational protein targeting to membrane (GO:0006613)	4.20905842
15	protein targeting to ER (GO:0045047)	4.20626598
16	protein localization to endoplasmic reticulum (GO:0070972)	4.00511882
17	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.97267612
18	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.82009583
19	ATP synthesis coupled proton transport (GO:0015986)	3.82009583
20	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.79246956
21	proteasome assembly (GO:0043248)	3.73645695
22	positive regulation of B cell differentiation (GO:0045579)	3.70166824
23	Arp2/3 complex-mediated actin nucleation (GO:0034314)	3.65451928
24	viral life cycle (GO:0019058)	3.64282153
25	maturation of SSU-rRNA (GO:0030490)	3.63490911
26	cellular protein complex disassembly (GO:0043624)	3.62467215
27	negative regulation by host of viral transcription (GO:0043922)	3.60251498
28	platelet dense granule organization (GO:0060155)	3.59132716
29	protein neddylation (GO:0045116)	3.53140660
30	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.51606398
31	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.45769995
32	positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)	3.45510281
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.36806810
34	translational initiation (GO:0006413)	3.33760042
35	actin nucleation (GO:0045010)	3.29755971
36	sequestering of actin monomers (GO:0042989)	3.28793891
37	positive regulation of natural killer cell mediated immunity (GO:0002717)	3.27392983
38	chaperone-mediated protein transport (GO:0072321)	3.26562006
39	response to pheromone (GO:0019236)	3.24317845
40	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.23471842
41	protein complex biogenesis (GO:0070271)	3.22421896
42	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.19374981
43	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.19374981
44	pyrimidine nucleoside catabolic process (GO:0046135)	3.17533911
45	regulation of activation of Janus kinase activity (GO:0010533)	3.17533518
46	DNA strand renaturation (GO:0000733)	3.13673540
47	negative regulation of T cell apoptotic process (GO:0070233)	3.11750011
48	translation (GO:0006412)	3.10485643
49	respiratory electron transport chain (GO:0022904)	3.08346084
50	electron transport chain (GO:0022900)	3.05914054
51	axoneme assembly (GO:0035082)	3.02143075
52	ribosomal large subunit biogenesis (GO:0042273)	2.98855388
53	protein complex disassembly (GO:0043241)	2.97867978
54	iron-sulfur cluster assembly (GO:0016226)	2.96155363
55	metallo-sulfur cluster assembly (GO:0031163)	2.96155363
56	cytolysis (GO:0019835)	2.95143257
57	behavioral response to nicotine (GO:0035095)	2.91069499
58	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.90241499
59	cell proliferation in forebrain (GO:0021846)	2.89937851
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.89723935
61	cellular component biogenesis (GO:0044085)	2.89589674
62	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85419153
63	NADH dehydrogenase complex assembly (GO:0010257)	2.85419153
64	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85419153
65	macromolecular complex disassembly (GO:0032984)	2.85225323
66	ribonucleoprotein complex biogenesis (GO:0022613)	2.84801399
67	T cell migration (GO:0072678)	2.83000041
68	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.81877855
69	mannosylation (GO:0097502)	2.79749049
70	positive regulation of T cell apoptotic process (GO:0070234)	2.79048564
71	regulation of cellular amino acid metabolic process (GO:0006521)	2.77334684
72	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.76802232
73	positive regulation of leukocyte mediated cytotoxicity (GO:0001912)	2.74704348
74	regulation of natural killer cell mediated immunity (GO:0002715)	2.74383738
75	regulation of natural killer cell mediated cytotoxicity (GO:0042269)	2.74383738
76	DNA demethylation (GO:0080111)	2.72107791
77	water-soluble vitamin biosynthetic process (GO:0042364)	2.68914644
78	positive T cell selection (GO:0043368)	2.67283935
79	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.65864185
80	termination of RNA polymerase III transcription (GO:0006386)	2.65864185
81	positive regulation of calcium-mediated signaling (GO:0050850)	2.65159461
82	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.64928098
83	male meiosis I (GO:0007141)	2.64871540
84	pyrimidine nucleotide catabolic process (GO:0006244)	2.63290270
85	protein targeting to membrane (GO:0006612)	2.62181913
86	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.61514468
87	nuclear-transcribed mRNA catabolic process (GO:0000956)	2.59103985
88	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.57816481
89	regulation of B cell differentiation (GO:0045577)	2.57696615
90	positive thymic T cell selection (GO:0045059)	2.57272868
91	pyrimidine-containing compound catabolic process (GO:0072529)	2.55372720
92	ncRNA 3-end processing (GO:0043628)	2.54892524
93	adaptation of signaling pathway (GO:0023058)	2.52299280
94	antigen processing and presentation via MHC class Ib (GO:0002475)	2.50894642
95	ubiquinone biosynthetic process (GO:0006744)	2.50644897
96	response to interferon-beta (GO:0035456)	2.50622640
97	positive regulation of translational initiation (GO:0045948)	2.50453480
98	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	2.50418460
99	deoxyribonucleotide catabolic process (GO:0009264)	2.50218237
100	pseudouridine synthesis (GO:0001522)	2.48909708

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.69007726
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.26298445
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.89675651
4	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.76254090
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.61123511
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.34969422
7	VDR_22108803_ChIP-Seq_LS180_Human	2.93348006
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.84439072
9	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.72143296
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.61509125
11	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.52801348
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.49783607
13	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.44904750
14	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.42476785
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.23082879
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.17546807
17	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14141584
18	ZNF274_21170338_ChIP-Seq_K562_Hela	1.99437362
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.97178682
20	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.96249478
21	FOXP3_21729870_ChIP-Seq_TREG_Human	1.79589489
22	MYC_18940864_ChIP-ChIP_HL60_Human	1.70400796
23	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.66783487
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.66672002
25	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.62816728
26	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.57697632
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.56659942
28	TP53_22573176_ChIP-Seq_HFKS_Human	1.53732911
29	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.52034857
30	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51269893
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48590523
32	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.43615901
33	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.41470655
34	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.39361468
35	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.38593317
36	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.37620429
37	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36425552
38	NANOG_20526341_ChIP-Seq_ESCs_Human	1.35708762
39	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.35411329
40	EWS_26573619_Chip-Seq_HEK293_Human	1.35136166
41	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.34903883
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.34077511
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.34077511
44	MYB_26560356_Chip-Seq_TH2_Human	1.33347171
45	NCOR_22424771_ChIP-Seq_293T_Human	1.31547274
46	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.30268404
47	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.29475098
48	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.29385718
49	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.28171201
50	AR_20517297_ChIP-Seq_VCAP_Human	1.28013225
51	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.27597828
52	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.25543262
53	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23963638
54	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23838885
55	TAF2_19829295_ChIP-Seq_ESCs_Human	1.23806438
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.20214433
57	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.19089694
58	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.16701101
59	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14687778
60	BCL6_27268052_Chip-Seq_Bcells_Human	1.14467691
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.14418237
62	HTT_18923047_ChIP-ChIP_STHdh_Human	1.12921390
63	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.12335813
64	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.11253417
65	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.09746632
66	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08985764
67	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.08443507
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08366787
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.07408247
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.07408247
71	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.06791823
72	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.06659795
73	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02787776
74	ER_23166858_ChIP-Seq_MCF-7_Human	1.02527101
75	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02388710
76	ERA_21632823_ChIP-Seq_H3396_Human	1.01886784
77	GATA3_26560356_Chip-Seq_TH2_Human	1.00753079
78	MYC_19829295_ChIP-Seq_ESCs_Human	0.99994554
79	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99656824
80	P53_21459846_ChIP-Seq_SAOS-2_Human	0.99200488
81	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	0.98986121
82	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.98968887
83	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.97286023
84	RUNX_20019798_ChIP-Seq_JUKART_Human	0.97054389
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95138988
86	IRF1_19129219_ChIP-ChIP_H3396_Human	0.95020928
87	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.94382320
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93432532
89	FUS_26573619_Chip-Seq_HEK293_Human	0.93404344
90	GABP_19822575_ChIP-Seq_HepG2_Human	0.93036122
91	ERG_20517297_ChIP-Seq_VCAP_Human	0.91959823
92	TTF2_22483619_ChIP-Seq_HELA_Human	0.91941637
93	CTCF_20526341_ChIP-Seq_ESCs_Human	0.91143863
94	P300_27268052_Chip-Seq_Bcells_Human	0.90878629
95	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.90677119
96	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.86462411
97	CBP_20019798_ChIP-Seq_JUKART_Human	0.86462411
98	GATA3_27048872_Chip-Seq_THYMUS_Human	0.85841766
99	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.85605519
100	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	0.85280156

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.44146475
2	MP0006292_abnormal_olfactory_placode	3.61423102
3	MP0009379_abnormal_foot_pigmentation	3.35268439
4	MP0002102_abnormal_ear_morphology	3.13632245
5	MP0001835_abnormal_antigen_presentation	2.67118126
6	MP0005377_hearing/vestibular/ear_phenot	2.61308310
7	MP0003878_abnormal_ear_physiology	2.61308310
8	MP0008877_abnormal_DNA_methylation	2.12165018
9	MP0003646_muscle_fatigue	2.11525817
10	MP0003787_abnormal_imprinting	2.02260357
11	MP0002166_altered_tumor_susceptibility	2.00098507
12	MP0009333_abnormal_splenocyte_physiolog	1.96982054
13	MP0002837_dystrophic_cardiac_calcinosis	1.96377519
14	MP0001873_stomach_inflammation	1.91501411
15	MP0009785_altered_susceptibility_to	1.82177586
16	MP0006072_abnormal_retinal_apoptosis	1.81868393
17	MP0000372_irregular_coat_pigmentation	1.80169709
18	MP0003763_abnormal_thymus_physiology	1.60144734
19	MP0002006_tumorigenesis	1.59094070
20	MP0001485_abnormal_pinna_reflex	1.58957497
21	MP0004145_abnormal_muscle_electrophysio	1.58620325
22	MP0005551_abnormal_eye_electrophysiolog	1.57783297
23	MP0008995_early_reproductive_senescence	1.54062049
24	MP0008872_abnormal_physiological_respon	1.51057048
25	MP0005645_abnormal_hypothalamus_physiol	1.49849530
26	MP0005646_abnormal_pituitary_gland	1.48540191
27	MP0001800_abnormal_humoral_immune	1.48087634
28	MP0004147_increased_porphyrin_level	1.46935550
29	MP0005084_abnormal_gallbladder_morpholo	1.46527668
30	MP0001968_abnormal_touch/_nociception	1.46116778
31	MP0005389_reproductive_system_phenotype	1.46012657
32	MP0002163_abnormal_gland_morphology	1.44912652
33	MP0002160_abnormal_reproductive_system	1.42571470
34	MP0001764_abnormal_homeostasis	1.42278207
35	MP0002148_abnormal_hypersensitivity_rea	1.40344869
36	MP0001188_hyperpigmentation	1.36767689
37	MP0002638_abnormal_pupillary_reflex	1.36335713
38	MP0008789_abnormal_olfactory_epithelium	1.35385635
39	MP0002876_abnormal_thyroid_physiology	1.33501170
40	MP0002736_abnormal_nociception_after	1.33294861
41	MP0005000_abnormal_immune_tolerance	1.32602509
42	MP0002723_abnormal_immune_serum	1.30180224
43	MP0002420_abnormal_adaptive_immunity	1.29731415
44	MP0004142_abnormal_muscle_tone	1.28237203
45	MP0008875_abnormal_xenobiotic_pharmacok	1.27861931
46	MP0000685_abnormal_immune_system	1.26803506
47	MP0006082_CNS_inflammation	1.24878832
48	MP0001819_abnormal_immune_cell	1.24117448
49	MP0003786_premature_aging	1.23433714
50	MP0001919_abnormal_reproductive_system	1.22849404
51	MP0001905_abnormal_dopamine_level	1.21766088
52	MP0005025_abnormal_response_to	1.17885163
53	MP0004885_abnormal_endolymph	1.16352886
54	MP0005075_abnormal_melanosome_morpholog	1.14637651
55	MP0003011_delayed_dark_adaptation	1.13965932
56	MP0001986_abnormal_taste_sensitivity	1.12124012
57	MP0000716_abnormal_immune_system	1.10514787
58	MP0002234_abnormal_pharynx_morphology	1.09730820
59	MP0003866_abnormal_defecation	1.09087486
60	MP0002398_abnormal_bone_marrow	1.08961079
61	MP0002277_abnormal_respiratory_mucosa	1.08050156
62	MP0005387_immune_system_phenotype	1.07008602
63	MP0001790_abnormal_immune_system	1.07008602
64	MP0005253_abnormal_eye_physiology	1.06997207
65	MP0002138_abnormal_hepatobiliary_system	1.05500431
66	MP0006276_abnormal_autonomic_nervous	1.03400908
67	MP0000631_abnormal_neuroendocrine_gland	1.02813420
68	MP0002095_abnormal_skin_pigmentation	0.98590668
69	MP0000049_abnormal_middle_ear	0.96100606
70	MP0002452_abnormal_antigen_presenting	0.95392965
71	MP0002933_joint_inflammation	0.94716989
72	MP0000689_abnormal_spleen_morphology	0.94674978
73	MP0002132_abnormal_respiratory_system	0.94614695
74	MP0000703_abnormal_thymus_morphology	0.93913418
75	MP0005360_urolithiasis	0.93746985
76	MP0000678_abnormal_parathyroid_gland	0.92945272
77	MP0010155_abnormal_intestine_physiology	0.92848546
78	MP0003121_genomic_imprinting	0.92107225
79	MP0005379_endocrine/exocrine_gland_phen	0.91293596
80	MP0002653_abnormal_ependyma_morphology	0.90546548
81	MP0003123_paternal_imprinting	0.88817595
82	MP0002272_abnormal_nervous_system	0.88711654
83	MP0008058_abnormal_DNA_repair	0.88664756
84	MP0001293_anophthalmia	0.88515437
85	MP0001119_abnormal_female_reproductive	0.88372714
86	MP0001963_abnormal_hearing_physiology	0.88043256
87	MP0000681_abnormal_thyroid_gland	0.87367186
88	MP0002722_abnormal_immune_system	0.85588475
89	MP0002405_respiratory_system_inflammati	0.85005542
90	MP0002429_abnormal_blood_cell	0.83295764
91	MP0004742_abnormal_vestibular_system	0.82726056
92	MP0005410_abnormal_fertilization	0.82292504
93	MP0001529_abnormal_vocalization	0.82204741
94	MP0005083_abnormal_biliary_tract	0.81165023
95	MP0002210_abnormal_sex_determination	0.80762101
96	MP0003567_abnormal_fetal_cardiomyocyte	0.80378874
97	MP0004043_abnormal_pH_regulation	0.78481886
98	MP0003252_abnormal_bile_duct	0.78034920
99	MP0005394_taste/olfaction_phenotype	0.77605976
100	MP0005499_abnormal_olfactory_system	0.77605976

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.87549591
2	Elevated erythrocyte sedimentation rate (HP:0003565)	4.42445702
3	Abnormal rod and cone electroretinograms (HP:0008323)	3.97771195
4	Acute necrotizing encephalopathy (HP:0006965)	3.97203313
5	Mitochondrial inheritance (HP:0001427)	3.80614002
6	Aplastic anemia (HP:0001915)	3.71652575
7	Abnormal mitochondria in muscle tissue (HP:0008316)	3.60702886
8	Severe combined immunodeficiency (HP:0004430)	3.35079177
9	Acute encephalopathy (HP:0006846)	3.26302763
10	Increased CSF lactate (HP:0002490)	3.17624676
11	Progressive macrocephaly (HP:0004481)	3.17601195
12	Reticulocytopenia (HP:0001896)	3.13590838
13	Congenital stationary night blindness (HP:0007642)	3.12562877
14	Hypoproteinemia (HP:0003075)	3.11215634
15	Increased IgM level (HP:0003496)	3.08277024
16	IgG deficiency (HP:0004315)	3.07058036
17	T lymphocytopenia (HP:0005403)	3.06129759
18	3-Methylglutaconic aciduria (HP:0003535)	3.05506486
19	Cerebral edema (HP:0002181)	3.03627539
20	Increased hepatocellular lipid droplets (HP:0006565)	3.02245377
21	Hepatocellular necrosis (HP:0001404)	2.99427954
22	Abnormality of cells of the erythroid lineage (HP:0012130)	2.95340829
23	Abnormality of T cell number (HP:0011839)	2.93183016
24	Muscle fiber atrophy (HP:0100295)	2.92883088
25	Chronic sinusitis (HP:0011109)	2.82896381
26	Increased intramyocellular lipid droplets (HP:0012240)	2.81826829
27	Abnormality of midbrain morphology (HP:0002418)	2.79451456
28	Molar tooth sign on MRI (HP:0002419)	2.79451456
29	Abnormality of B cell number (HP:0010975)	2.78977080
30	B lymphocytopenia (HP:0010976)	2.78262275
31	Optic disc pallor (HP:0000543)	2.77385612
32	Decreased central vision (HP:0007663)	2.77067364
33	Pancreatic cysts (HP:0001737)	2.75383294
34	Lipid accumulation in hepatocytes (HP:0006561)	2.75030695
35	Abolished electroretinogram (ERG) (HP:0000550)	2.73748267
36	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.73073250
37	Thyroiditis (HP:0100646)	2.71364127
38	True hermaphroditism (HP:0010459)	2.64080757
39	Hepatic necrosis (HP:0002605)	2.58438880
40	Renal Fanconi syndrome (HP:0001994)	2.57982404
41	Abnormality of the prostate (HP:0008775)	2.55077504
42	Abnormal number of erythroid precursors (HP:0012131)	2.52911342
43	Pancreatic fibrosis (HP:0100732)	2.51715547
44	Combined immunodeficiency (HP:0005387)	2.49753712
45	Attenuation of retinal blood vessels (HP:0007843)	2.49280748
46	Chronic otitis media (HP:0000389)	2.39411725
47	Recurrent bronchitis (HP:0002837)	2.38392150
48	Respiratory difficulties (HP:0002880)	2.35901755
49	Autoimmune hemolytic anemia (HP:0001890)	2.35802754
50	Macrocytic anemia (HP:0001972)	2.35147390
51	Abnormality of T cells (HP:0002843)	2.33682969
52	Increased muscle lipid content (HP:0009058)	2.31622963
53	Stenosis of the external auditory canal (HP:0000402)	2.24533338
54	Abnormality of eosinophils (HP:0001879)	2.19902897
55	Lactic acidosis (HP:0003128)	2.12091144
56	Hyperglycinemia (HP:0002154)	2.11701035
57	Absent thumb (HP:0009777)	2.10307691
58	Increased serum lactate (HP:0002151)	2.09171079
59	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.09134287
60	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.09134287
61	Constricted visual fields (HP:0001133)	2.08655267
62	Large eyes (HP:0001090)	2.08552903
63	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.07781084
64	Pancytopenia (HP:0001876)	2.07610844
65	Type I transferrin isoform profile (HP:0003642)	2.06926885
66	Pallor (HP:0000980)	2.06375495
67	Abnormality of macular pigmentation (HP:0008002)	2.06303866
68	Asplenia (HP:0001746)	2.05293615
69	Encephalitis (HP:0002383)	2.04721055
70	Medial flaring of the eyebrow (HP:0010747)	2.04475801
71	Type 2 muscle fiber atrophy (HP:0003554)	2.04451919
72	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.04298616
73	Severe visual impairment (HP:0001141)	2.03289773
74	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.01360160
75	Colon cancer (HP:0003003)	2.00227069
76	Nephronophthisis (HP:0000090)	1.99537580
77	Agammaglobulinemia (HP:0004432)	1.96632997
78	Lethargy (HP:0001254)	1.93722543
79	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.92001630
80	Absent/shortened dynein arms (HP:0200106)	1.92001630
81	Abnormal protein glycosylation (HP:0012346)	1.85559696
82	Abnormal glycosylation (HP:0012345)	1.85559696
83	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.85559696
84	Abnormal protein N-linked glycosylation (HP:0012347)	1.85559696
85	Hypoplasia of the thymus (HP:0000778)	1.85024760
86	Exercise intolerance (HP:0003546)	1.84724380
87	Abnormality of DNA repair (HP:0003254)	1.84397824
88	Abnormality of the renal cortex (HP:0011035)	1.84380408
89	Exertional dyspnea (HP:0002875)	1.82909641
90	Pendular nystagmus (HP:0012043)	1.82413328
91	Type II lissencephaly (HP:0007260)	1.76380140
92	Abnormal respiratory epithelium morphology (HP:0012253)	1.75837145
93	Abnormal respiratory motile cilium morphology (HP:0005938)	1.75837145
94	Panhypogammaglobulinemia (HP:0003139)	1.73672250
95	Stomatitis (HP:0010280)	1.72857562
96	Methylmalonic acidemia (HP:0002912)	1.72844231
97	Respiratory failure (HP:0002878)	1.72699518
98	Hypergammaglobulinemia (HP:0010702)	1.72486443
99	Eosinophilia (HP:0001880)	1.72416025
100	Rib fusion (HP:0000902)	1.71184567

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.07509381
2	KDR	3.88182644
3	TESK2	3.79284444
4	BCKDK	3.51896781
5	CDK19	2.83566500
6	VRK2	2.77660274
7	ZAK	2.71933789
8	MAP4K2	2.58535600
9	GRK1	2.37528265
10	ADRBK2	2.37110567
11	NUAK1	2.28866726
12	TAOK3	2.11552382
13	STK16	2.11107449
14	VRK1	2.03622469
15	WNK4	1.86635609
16	GRK7	1.85568810
17	LIMK1	1.68240839
18	TLK1	1.56870670
19	MAP4K1	1.46577266
20	ITK	1.46283161
21	TIE1	1.35320242
22	KIT	1.26918776
23	WNK3	1.26448621
24	PRKCQ	1.24986126
25	PASK	1.24146677
26	FRK	1.23854863
27	DYRK2	1.20071183
28	MAP3K11	1.19362796
29	EIF2AK3	1.12450072
30	SYK	1.11768931
31	CAMKK2	1.07171394
32	TEC	1.03606697
33	TNK2	1.02574685
34	TAF1	1.02004196
35	PLK4	1.00096231
36	FES	0.99513999
37	CDC7	0.97418804
38	PINK1	0.96407990
39	PIK3CA	0.95251660
40	TESK1	0.88872199
41	LCK	0.88698654
42	INSRR	0.87207849
43	AURKA	0.86698489
44	MAP3K12	0.84947543
45	GRK5	0.81391135
46	PIM1	0.77407550
47	BMPR1B	0.77399238
48	NEK2	0.77044210
49	LRRK2	0.76573928
50	MAPK13	0.76459549
51	OBSCN	0.74086671
52	BTK	0.73270538
53	GRK6	0.72795384
54	ADRBK1	0.72487238
55	RPS6KA5	0.70876560
56	OXSR1	0.70248882
57	MATK	0.70230118
58	CSNK1G1	0.70064391
59	DAPK1	0.67819784
60	IKBKE	0.62672409
61	LYN	0.62499138
62	IKBKB	0.62434448
63	CSNK1G3	0.62383984
64	SCYL2	0.59037976
65	NME2	0.57907790
66	DAPK3	0.55540600
67	STK39	0.54265473
68	EIF2AK2	0.53029811
69	PIM2	0.51892510
70	DAPK2	0.49984160
71	NME1	0.49487392
72	PRKACA	0.49254452
73	TRIM28	0.49145507
74	PIK3CG	0.48495941
75	BUB1	0.48139546
76	TGFBR2	0.46489978
77	PRKCG	0.44900931
78	CSNK2A2	0.43538068
79	CSNK1G2	0.42752563
80	PRKCD	0.42638131
81	CSNK2A1	0.41654916
82	MARK3	0.41632129
83	CSK	0.41612409
84	PRKCA	0.41455713
85	CCNB1	0.41445083
86	MAP2K7	0.40758397
87	ATR	0.40556422
88	TYRO3	0.39019226
89	CHEK2	0.37268461
90	MAPKAPK5	0.37005901
91	AURKB	0.36713499
92	CDK3	0.36089909
93	MUSK	0.36020735
94	CAMKK1	0.35486241
95	MAP3K4	0.35214364
96	PRKCE	0.33852875
97	PLK1	0.32247242
98	MOS	0.31956265
99	CAMK1	0.31118057
100	CSF1R	0.30530148

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.71379176
2	Primary immunodeficiency_Homo sapiens_hsa05340	4.39976673
3	Proteasome_Homo sapiens_hsa03050	3.81295984
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.33890884
5	Parkinsons disease_Homo sapiens_hsa05012	2.81785285
6	RNA polymerase_Homo sapiens_hsa03020	2.38563137
7	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.01395729
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94203889
9	Phototransduction_Homo sapiens_hsa04744	1.91440798
10	Protein export_Homo sapiens_hsa03060	1.86907040
11	Huntingtons disease_Homo sapiens_hsa05016	1.85487205
12	Allograft rejection_Homo sapiens_hsa05330	1.84325645
13	Cardiac muscle contraction_Homo sapiens_hsa04260	1.81946664
14	Graft-versus-host disease_Homo sapiens_hsa05332	1.81209166
15	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.80306954
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.79368062
17	Alzheimers disease_Homo sapiens_hsa05010	1.77871019
18	Antigen processing and presentation_Homo sapiens_hsa04612	1.75644904
19	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75320239
20	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.68287066
21	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.57002033
22	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.52080836
23	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.49609513
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.49335985
25	Homologous recombination_Homo sapiens_hsa03440	1.40264525
26	Fanconi anemia pathway_Homo sapiens_hsa03460	1.37883747
27	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36504936
28	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.34342431
29	RNA degradation_Homo sapiens_hsa03018	1.34232721
30	DNA replication_Homo sapiens_hsa03030	1.28122954
31	Peroxisome_Homo sapiens_hsa04146	1.26370585
32	Caffeine metabolism_Homo sapiens_hsa00232	1.19552561
33	Basal transcription factors_Homo sapiens_hsa03022	1.18008958
34	Butanoate metabolism_Homo sapiens_hsa00650	1.16831020
35	Propanoate metabolism_Homo sapiens_hsa00640	1.16773824
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.16752627
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11711665
38	Mismatch repair_Homo sapiens_hsa03430	1.07640895
39	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06379946
40	Asthma_Homo sapiens_hsa05310	1.05686734
41	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.04284119
42	Olfactory transduction_Homo sapiens_hsa04740	1.04241596
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.99828623
44	Retinol metabolism_Homo sapiens_hsa00830	0.99695218
45	Rheumatoid arthritis_Homo sapiens_hsa05323	0.95706384
46	Nucleotide excision repair_Homo sapiens_hsa03420	0.94824349
47	Purine metabolism_Homo sapiens_hsa00230	0.93232160
48	Nitrogen metabolism_Homo sapiens_hsa00910	0.91917252
49	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.89871707
50	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.88866747
51	One carbon pool by folate_Homo sapiens_hsa00670	0.85784321
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.82585127
53	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.80756432
54	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.78983717
55	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.78716046
56	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.78053860
57	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.76669574
58	Base excision repair_Homo sapiens_hsa03410	0.76501418
59	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.75631445
60	Ether lipid metabolism_Homo sapiens_hsa00565	0.75252770
61	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.74135275
62	Tryptophan metabolism_Homo sapiens_hsa00380	0.70776178
63	RNA transport_Homo sapiens_hsa03013	0.69518236
64	beta-Alanine metabolism_Homo sapiens_hsa00410	0.69455068
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.66474353
66	Sulfur metabolism_Homo sapiens_hsa00920	0.65737539
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61591440
68	Metabolic pathways_Homo sapiens_hsa01100	0.61497529
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.60830864
70	Spliceosome_Homo sapiens_hsa03040	0.58229313
71	Measles_Homo sapiens_hsa05162	0.51878206
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.51228639
73	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.51045965
74	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.49713811
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.48689825
76	Regulation of autophagy_Homo sapiens_hsa04140	0.47705882
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.47393496
78	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.46073048
79	Fatty acid degradation_Homo sapiens_hsa00071	0.45512477
80	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44814151
81	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.44438032
82	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.44429053
83	ABC transporters_Homo sapiens_hsa02010	0.41313496
84	Sulfur relay system_Homo sapiens_hsa04122	0.40219041
85	Viral myocarditis_Homo sapiens_hsa05416	0.39279408
86	Malaria_Homo sapiens_hsa05144	0.39101805
87	Nicotine addiction_Homo sapiens_hsa05033	0.38009107
88	Fatty acid elongation_Homo sapiens_hsa00062	0.37744387
89	Salivary secretion_Homo sapiens_hsa04970	0.37334323
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.36081819
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.34644756
92	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.34116651
93	Taste transduction_Homo sapiens_hsa04742	0.33626690
94	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.30334559
95	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29145312
96	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.28297712
97	Herpes simplex infection_Homo sapiens_hsa05168	0.25020353
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.23257808
99	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.21824904
100	Tyrosine metabolism_Homo sapiens_hsa00350	0.21554885

RPL7AP66

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »