ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	nucleotide salvage (GO:0043173)	8.36862878
2	pyrimidine nucleoside salvage (GO:0043097)	8.21956005
3	pyrimidine-containing compound salvage (GO:0008655)	8.21956005
4	nucleoside salvage (GO:0043174)	7.61854194
5	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	7.44167061
6	UMP metabolic process (GO:0046049)	7.44167061
7	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	7.44167061
8	UMP biosynthetic process (GO:0006222)	7.44167061
9	viral transcription (GO:0019083)	6.80093861
10	translational termination (GO:0006415)	6.62042506
11	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	6.43551952
12	response to pheromone (GO:0019236)	6.43195088
13	CTP metabolic process (GO:0046036)	6.25929702
14	CTP biosynthetic process (GO:0006241)	6.25929702
15	pyrimidine nucleoside monophosphate metabolic process (GO:0009129)	6.15110175
16	translational elongation (GO:0006414)	5.94202789
17	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	5.76523206
18	ribosomal small subunit assembly (GO:0000028)	5.71383627
19	pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)	5.38118671
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.28778465
21	cellular protein complex disassembly (GO:0043624)	5.24181509
22	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	5.20980999
23	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	5.20980999
24	pentose metabolic process (GO:0019321)	5.15310855
25	cotranslational protein targeting to membrane (GO:0006613)	5.14816836
26	protein targeting to ER (GO:0045047)	5.13320609
27	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	5.07301872
28	maturation of SSU-rRNA (GO:0030490)	5.03879919
29	diterpenoid biosynthetic process (GO:0016102)	4.97050095
30	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.92319794
31	regulation of glycogen (starch) synthase activity (GO:2000465)	4.77540938
32	protein localization to endoplasmic reticulum (GO:0070972)	4.76269938
33	keratinocyte development (GO:0003334)	4.76053563
34	viral life cycle (GO:0019058)	4.70111181
35	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	4.62097417
36	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.60704234
37	protein complex disassembly (GO:0043241)	4.56575573
38	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.53479652
39	ribosomal small subunit biogenesis (GO:0042274)	4.45389683
40	pyrimidine ribonucleoside biosynthetic process (GO:0046132)	4.30578361
41	macromolecular complex disassembly (GO:0032984)	4.28649886
42	pyrimidine ribonucleotide biosynthetic process (GO:0009220)	4.06844812
43	translational initiation (GO:0006413)	4.03702729
44	behavioral response to nicotine (GO:0035095)	3.91785313
45	cellular metabolic compound salvage (GO:0043094)	3.78766994
46	regulation of activation of Janus kinase activity (GO:0010533)	3.71232509
47	pyrimidine ribonucleotide metabolic process (GO:0009218)	3.67442929
48	terpenoid biosynthetic process (GO:0016114)	3.66809868
49	pentose-phosphate shunt (GO:0006098)	3.64994221
50	DNA deamination (GO:0045006)	3.58328523
51	purine nucleotide salvage (GO:0032261)	3.45886405
52	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.45731032
53	ribosomal large subunit biogenesis (GO:0042273)	3.44847054
54	translation (GO:0006412)	3.39997229
55	pyrimidine ribonucleoside metabolic process (GO:0046131)	3.39296068
56	protein targeting to membrane (GO:0006612)	3.38970812
57	pyrimidine nucleotide biosynthetic process (GO:0006221)	3.25281062
58	mitochondrial respiratory chain complex assembly (GO:0033108)	3.21345374
59	protein complex biogenesis (GO:0070271)	3.20150871
60	NADPH regeneration (GO:0006740)	3.14200703
61	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.12762515
62	ATP synthesis coupled proton transport (GO:0015986)	3.12762515
63	activation of NF-kappaB-inducing kinase activity (GO:0007250)	3.05967598
64	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.04995051
65	peptidyl-cysteine modification (GO:0018198)	3.03444760
66	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.01755145
67	DNA dealkylation (GO:0035510)	3.01217110
68	pyrimidine nucleoside biosynthetic process (GO:0046134)	3.01117040
69	response to folic acid (GO:0051593)	3.00601649
70	tRNA modification (GO:0006400)	2.99986837
71	epithelial cilium movement (GO:0003351)	2.93756386
72	L-methionine salvage (GO:0071267)	2.90628223
73	L-methionine biosynthetic process (GO:0071265)	2.90628223
74	amino acid salvage (GO:0043102)	2.90628223
75	cell proliferation in forebrain (GO:0021846)	2.90522950
76	autophagic vacuole fusion (GO:0000046)	2.86450511
77	mRNA catabolic process (GO:0006402)	2.84072740
78	negative regulation of JAK-STAT cascade (GO:0046426)	2.82205629
79	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	2.78346197
80	protein polyglutamylation (GO:0018095)	2.69631774
81	DNA ligation (GO:0006266)	2.69189236
82	catecholamine transport (GO:0051937)	2.66149190
83	piRNA metabolic process (GO:0034587)	2.63808267
84	S-adenosylmethionine metabolic process (GO:0046500)	2.62711999
85	rRNA modification (GO:0000154)	2.61724385
86	RNA catabolic process (GO:0006401)	2.59215563
87	pyrimidine nucleotide metabolic process (GO:0006220)	2.56514888
88	glucose catabolic process (GO:0006007)	2.53200564
89	rRNA methylation (GO:0031167)	2.52243659
90	nucleoside triphosphate biosynthetic process (GO:0009142)	2.49657876
91	pattern specification involved in kidney development (GO:0061004)	2.48912037
92	grooming behavior (GO:0007625)	2.48109011
93	tRNA processing (GO:0008033)	2.47768538
94	regulation of action potential (GO:0098900)	2.47385500
95	cytochrome complex assembly (GO:0017004)	2.47112810
96	interleukin-6-mediated signaling pathway (GO:0070102)	2.45444395
97	peptidyl-lysine dimethylation (GO:0018027)	2.43809162
98	pyrimidine-containing compound biosynthetic process (GO:0072528)	2.42790693
99	respiratory chain complex IV assembly (GO:0008535)	2.39280981
100	cellular component biogenesis (GO:0044085)	2.39266438

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.00388807
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.26407511
3	IKZF1_21737484_ChIP-ChIP_HCT116_Human	3.50792948
4	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	3.10175332
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.68037936
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.34021940
7	VDR_22108803_ChIP-Seq_LS180_Human	2.33496728
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.23844264
9	IRF1_19129219_ChIP-ChIP_H3396_Human	1.99100505
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.96660309
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.93422864
12	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.88819619
13	ERA_21632823_ChIP-Seq_H3396_Human	1.74834946
14	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.73200343
15	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.70364055
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.69469440
17	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.68946686
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.68003565
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.66948799
20	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.66928645
21	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64219916
22	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.61461547
23	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.61172742
24	IGF1R_20145208_ChIP-Seq_DFB_Human	1.59757742
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.57312023
26	TP53_22573176_ChIP-Seq_HFKS_Human	1.56032762
27	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.54693612
28	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.53784107
29	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.53608331
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.51752316
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.51748888
32	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.47607642
33	RAC3_21632823_ChIP-Seq_H3396_Human	1.45304437
34	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.43569304
35	E2F1_20622854_ChIP-Seq_HELA_Human	1.41112511
36	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.39045800
37	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.38881783
38	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.35950900
39	NCOR_22424771_ChIP-Seq_293T_Human	1.33739045
40	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31908095
41	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.27036031
42	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.25305068
43	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.25258060
44	NANOG_20526341_ChIP-Seq_ESCs_Human	1.23276645
45	CTCF_20526341_ChIP-Seq_ESCs_Human	1.23242408
46	FUS_26573619_Chip-Seq_HEK293_Human	1.20892611
47	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.20084879
48	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18706062
49	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.18498202
50	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.18174522
51	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.18001152
52	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.16475704
53	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.15988311
54	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.15775630
55	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.15573622
56	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.14391168
57	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.14076316
58	P68_20966046_ChIP-Seq_HELA_Human	1.14060680
59	P53_21459846_ChIP-Seq_SAOS-2_Human	1.11371127
60	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.10839004
61	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10751539
62	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.09835840
63	MYC_18940864_ChIP-ChIP_HL60_Human	1.09542898
64	AR_20517297_ChIP-Seq_VCAP_Human	1.09369357
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.08815233
66	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.08522771
67	STAT1_20625510_ChIP-Seq_HELA_Human	1.08502162
68	SOX2_21211035_ChIP-Seq_LN229_Human	1.08336873
69	BCL6_27268052_Chip-Seq_Bcells_Human	1.07640863
70	VDR_23849224_ChIP-Seq_CD4+_Human	1.07178331
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.06410228
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.06410228
73	RNF2_27304074_Chip-Seq_NSC_Mouse	1.05467091
74	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05371798
75	TAF2_19829295_ChIP-Seq_ESCs_Human	1.05332445
76	MYC_19829295_ChIP-Seq_ESCs_Human	1.05111083
77	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.04801948
78	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03616788
79	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.03277770
80	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.03277770
81	BCAT_22108803_ChIP-Seq_LS180_Human	1.03156927
82	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.02797962
83	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.02432019
84	RUNX_20019798_ChIP-Seq_JUKART_Human	1.01691750
85	SA1_27219007_Chip-Seq_Bcells_Human	1.01267312
86	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.01028844
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00061516
88	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.99643696
89	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.98199011
90	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.97779315
91	CBP_20019798_ChIP-Seq_JUKART_Human	0.97758276
92	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.97758276
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97497927
94	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.96993567
95	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.96020394
96	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.95893315
97	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.95827238
98	CTCF_27219007_Chip-Seq_Bcells_Human	0.95093132
99	BCOR_27268052_Chip-Seq_Bcells_Human	0.93747831
100	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93651335

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.68959385
2	MP0009379_abnormal_foot_pigmentation	4.68702123
3	MP0002163_abnormal_gland_morphology	3.65497459
4	MP0003646_muscle_fatigue	3.31323840
5	MP0008875_abnormal_xenobiotic_pharmacok	3.11526119
6	MP0005379_endocrine/exocrine_gland_phen	2.27950015
7	MP0001348_abnormal_lacrimal_gland	2.26645657
8	MP0003724_increased_susceptibility_to	2.06058077
9	MP0008872_abnormal_physiological_respon	2.04370777
10	MP0005646_abnormal_pituitary_gland	2.02320541
11	MP0006072_abnormal_retinal_apoptosis	1.95429382
12	MP0001873_stomach_inflammation	1.95409403
13	MP0001986_abnormal_taste_sensitivity	1.91801848
14	MP0002234_abnormal_pharynx_morphology	1.91573218
15	MP0008789_abnormal_olfactory_epithelium	1.77520123
16	MP0004142_abnormal_muscle_tone	1.71718527
17	MP0005360_urolithiasis	1.68562088
18	MP0002837_dystrophic_cardiac_calcinosis	1.64288628
19	MP0005423_abnormal_somatic_nervous	1.64128400
20	MP0006276_abnormal_autonomic_nervous	1.59016254
21	MP0001968_abnormal_touch/_nociception	1.57728466
22	MP0005499_abnormal_olfactory_system	1.56170051
23	MP0005394_taste/olfaction_phenotype	1.56170051
24	MP0002102_abnormal_ear_morphology	1.48590348
25	MP0001293_anophthalmia	1.46196967
26	MP0008877_abnormal_DNA_methylation	1.45400667
27	MP0005645_abnormal_hypothalamus_physiol	1.40743555
28	MP0002733_abnormal_thermal_nociception	1.40128877
29	MP0000538_abnormal_urinary_bladder	1.37856171
30	MP0002653_abnormal_ependyma_morphology	1.37433537
31	MP0001663_abnormal_digestive_system	1.36437473
32	MP0005551_abnormal_eye_electrophysiolog	1.36152052
33	MP0001529_abnormal_vocalization	1.35906364
34	MP0003787_abnormal_imprinting	1.35141650
35	MP0002272_abnormal_nervous_system	1.30900335
36	MP0003806_abnormal_nucleotide_metabolis	1.30322416
37	MP0003122_maternal_imprinting	1.29801933
38	MP0005389_reproductive_system_phenotype	1.29099345
39	MP0001970_abnormal_pain_threshold	1.26340684
40	MP0001346_abnormal_lacrimal_gland	1.26170779
41	MP0002736_abnormal_nociception_after	1.25754254
42	MP0003880_abnormal_central_pattern	1.24568104
43	MP0008775_abnormal_heart_ventricle	1.24300861
44	MP0001919_abnormal_reproductive_system	1.20626777
45	MP0003879_abnormal_hair_cell	1.19231325
46	MP0009745_abnormal_behavioral_response	1.19081975
47	MP0009764_decreased_sensitivity_to	1.18067569
48	MP0004145_abnormal_muscle_electrophysio	1.16899684
49	MP0003121_genomic_imprinting	1.16890475
50	MP0002735_abnormal_chemical_nociception	1.15777737
51	MP0005410_abnormal_fertilization	1.13258966
52	MP0004885_abnormal_endolymph	1.12642702
53	MP0000372_irregular_coat_pigmentation	1.10589879
54	MP0001835_abnormal_antigen_presentation	1.09649057
55	MP0004133_heterotaxia	1.09515494
56	MP0005167_abnormal_blood-brain_barrier	1.05694178
57	MP0002160_abnormal_reproductive_system	1.05005651
58	MP0004742_abnormal_vestibular_system	1.03704175
59	MP0000049_abnormal_middle_ear	1.03089321
60	MP0005084_abnormal_gallbladder_morpholo	1.02336990
61	MP0001485_abnormal_pinna_reflex	1.02037799
62	MP0005671_abnormal_response_to	1.01744774
63	MP0010386_abnormal_urinary_bladder	1.00502696
64	MP0002638_abnormal_pupillary_reflex	1.00301710
65	MP0001905_abnormal_dopamine_level	0.99619781
66	MP0003878_abnormal_ear_physiology	0.99446630
67	MP0005377_hearing/vestibular/ear_phenot	0.99446630
68	MP0002277_abnormal_respiratory_mucosa	0.99251533
69	MP0005332_abnormal_amino_acid	0.96731529
70	MP0000613_abnormal_salivary_gland	0.95552969
71	MP0003119_abnormal_digestive_system	0.94141498
72	MP0009046_muscle_twitch	0.93639312
73	MP0003718_maternal_effect	0.92175096
74	MP0005195_abnormal_posterior_eye	0.91778731
75	MP0000778_abnormal_nervous_system	0.91363013
76	MP0005381_digestive/alimentary_phenotyp	0.91158699
77	MP0002184_abnormal_innervation	0.89005556
78	MP0002876_abnormal_thyroid_physiology	0.88191018
79	MP0002938_white_spotting	0.87688497
80	MP0002572_abnormal_emotion/affect_behav	0.85102131
81	MP0000383_abnormal_hair_follicle	0.84030858
82	MP0000631_abnormal_neuroendocrine_gland	0.83093459
83	MP0005000_abnormal_immune_tolerance	0.83065227
84	MP0002095_abnormal_skin_pigmentation	0.82482155
85	MP0005253_abnormal_eye_physiology	0.81882995
86	MP0003635_abnormal_synaptic_transmissio	0.81440971
87	MP0001800_abnormal_humoral_immune	0.80577451
88	MP0002734_abnormal_mechanical_nocicepti	0.80207583
89	MP0008995_early_reproductive_senescence	0.78926400
90	MP0003195_calcinosis	0.78908158
91	MP0001440_abnormal_grooming_behavior	0.78575629
92	MP0002822_catalepsy	0.76875211
93	MP0002557_abnormal_social/conspecific_i	0.75174903
94	MP0000427_abnormal_hair_cycle	0.75146602
95	MP0001790_abnormal_immune_system	0.74183271
96	MP0005387_immune_system_phenotype	0.74183271
97	MP0003136_yellow_coat_color	0.73794169
98	MP0004043_abnormal_pH_regulation	0.73558825
99	MP0001944_abnormal_pancreas_morphology	0.73525820
100	MP0005310_abnormal_salivary_gland	0.73449485

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the pons (HP:0012110)	4.71481978
2	Hip dysplasia (HP:0001385)	4.44975637
3	Abnormality of the pons (HP:0007361)	4.37959817
4	Reticulocytopenia (HP:0001896)	4.23886178
5	Abnormality of cells of the erythroid lineage (HP:0012130)	3.89929565
6	Difficulty running (HP:0009046)	3.61305658
7	Poor suck (HP:0002033)	3.42099734
8	Opisthotonus (HP:0002179)	3.41006876
9	Absent/shortened dynein arms (HP:0200106)	3.23898139
10	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.23898139
11	Hip contracture (HP:0003273)	3.22752713
12	Abnormal number of erythroid precursors (HP:0012131)	3.18870603
13	Acute necrotizing encephalopathy (HP:0006965)	3.18841785
14	Abnormality of midbrain morphology (HP:0002418)	3.16163229
15	Molar tooth sign on MRI (HP:0002419)	3.16163229
16	Aplasia/Hypoplasia of the spleen (HP:0010451)	3.04886905
17	Pancreatic fibrosis (HP:0100732)	2.97902975
18	Mitochondrial inheritance (HP:0001427)	2.96987782
19	Asplenia (HP:0001746)	2.94455489
20	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88690758
21	Hyperglycinemia (HP:0002154)	2.78984339
22	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.76405878
23	Macrocytic anemia (HP:0001972)	2.74887993
24	Achilles tendon contracture (HP:0001771)	2.66509135
25	Abnormal respiratory epithelium morphology (HP:0012253)	2.66408888
26	Abnormal respiratory motile cilium morphology (HP:0005938)	2.66408888
27	Abnormal drinking behavior (HP:0030082)	2.66121694
28	Polydipsia (HP:0001959)	2.66121694
29	Progressive macrocephaly (HP:0004481)	2.65502913
30	Acute encephalopathy (HP:0006846)	2.64857403
31	3-Methylglutaconic aciduria (HP:0003535)	2.64439807
32	Increased hepatocellular lipid droplets (HP:0006565)	2.62345662
33	Pancreatic cysts (HP:0001737)	2.60940791
34	Progressive microcephaly (HP:0000253)	2.60087915
35	Tubular atrophy (HP:0000092)	2.55780395
36	Abnormal rod and cone electroretinograms (HP:0008323)	2.54748123
37	Lipid accumulation in hepatocytes (HP:0006561)	2.53464842
38	Absent thumb (HP:0009777)	2.53289140
39	Supernumerary spleens (HP:0009799)	2.52741778
40	Stomatitis (HP:0010280)	2.52632618
41	Restlessness (HP:0000711)	2.52434078
42	Microretrognathia (HP:0000308)	2.51433940
43	Congenital stationary night blindness (HP:0007642)	2.47341485
44	Type II lissencephaly (HP:0007260)	2.46569917
45	Increased CSF lactate (HP:0002490)	2.46079822
46	Parakeratosis (HP:0001036)	2.43638526
47	Hypoplasia of the brainstem (HP:0002365)	2.42599780
48	Aplasia/Hypoplasia of the brainstem (HP:0007362)	2.42599780
49	Renal Fanconi syndrome (HP:0001994)	2.40102820
50	Abnormality of the Achilles tendon (HP:0005109)	2.33147633
51	Limited hip movement (HP:0008800)	2.32560695
52	Pendular nystagmus (HP:0012043)	2.29446589
53	Abnormal number of incisors (HP:0011064)	2.24082880
54	Abnormal hemoglobin (HP:0011902)	2.22891020
55	Polyuria (HP:0000103)	2.21934118
56	Optic disc pallor (HP:0000543)	2.19188629
57	Increased IgM level (HP:0003496)	2.19181907
58	Nephronophthisis (HP:0000090)	2.16265613
59	Enlarged kidneys (HP:0000105)	2.15962503
60	Abnormal ciliary motility (HP:0012262)	2.14706324
61	Hepatocellular necrosis (HP:0001404)	2.14690035
62	Hypomagnesemia (HP:0002917)	2.12075737
63	Dyskinesia (HP:0100660)	2.11257812
64	Congenital, generalized hypertrichosis (HP:0004540)	2.05712006
65	Abnormality of the renal medulla (HP:0100957)	2.04796907
66	Abnormality of the renal cortex (HP:0011035)	2.03977421
67	Abolished electroretinogram (ERG) (HP:0000550)	2.03517371
68	Increased intramyocellular lipid droplets (HP:0012240)	2.00320681
69	Pallor (HP:0000980)	1.99237294
70	Type 2 muscle fiber atrophy (HP:0003554)	1.98944524
71	Attenuation of retinal blood vessels (HP:0007843)	1.94541350
72	Potter facies (HP:0002009)	1.92862048
73	Facial shape deformation (HP:0011334)	1.92862048
74	Hepatic necrosis (HP:0002605)	1.92830574
75	Abnormality of chromosome stability (HP:0003220)	1.92153977
76	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.90924339
77	Elevated erythrocyte sedimentation rate (HP:0003565)	1.90605197
78	Impaired smooth pursuit (HP:0007772)	1.90578373
79	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.90056561
80	Lissencephaly (HP:0001339)	1.89232365
81	Agitation (HP:0000713)	1.86371705
82	Abnormal respiratory motile cilium physiology (HP:0012261)	1.85829614
83	Decreased central vision (HP:0007663)	1.85701853
84	Clubbing of toes (HP:0100760)	1.84837408
85	True hermaphroditism (HP:0010459)	1.84829067
86	Sclerocornea (HP:0000647)	1.83386973
87	Bony spicule pigmentary retinopathy (HP:0007737)	1.80935858
88	Abnormal urine output (HP:0012590)	1.80586770
89	Brushfield spots (HP:0001088)	1.80067208
90	Abnormality of magnesium homeostasis (HP:0004921)	1.79403874
91	Cerebral edema (HP:0002181)	1.75725283
92	Female pseudohermaphroditism (HP:0010458)	1.74563697
93	IgG deficiency (HP:0004315)	1.74284975
94	Cystic liver disease (HP:0006706)	1.73467196
95	Sacral dimple (HP:0000960)	1.73131531
96	Muscle fiber atrophy (HP:0100295)	1.72186677
97	Abnormality of the nasal septum (HP:0000419)	1.71977092
98	Cerebellar dysplasia (HP:0007033)	1.71608655
99	Abnormality of renal resorption (HP:0011038)	1.71483283
100	Pachygyria (HP:0001302)	1.70028355

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	LIMK1	4.33335121
2	ADRBK2	3.12683383
3	NUAK1	2.85053728
4	ZAK	2.84324042
5	STK16	2.80268852
6	BMPR1B	2.75438512
7	MAP4K1	2.74618077
8	WNK3	2.51819964
9	TXK	2.49245332
10	TAOK3	2.34574784
11	ACVR1B	2.18378310
12	TLK1	2.18354572
13	BCKDK	2.00285815
14	DYRK2	2.00088481
15	FRK	1.98589780
16	WNK4	1.86719827
17	MAP4K2	1.78833355
18	GRK1	1.72473706
19	CDK19	1.69917455
20	LRRK2	1.56181158
21	CSF1R	1.45542166
22	PRKCG	1.40437466
23	PRKCQ	1.29663246
24	KIT	1.27898298
25	PLK4	1.26191835
26	RPS6KA5	1.25244729
27	NME2	1.24594793
28	TGFBR1	1.24440488
29	TESK1	1.24355020
30	IKBKE	1.22670491
31	NTRK2	1.17406474
32	SIK2	1.07749588
33	TIE1	1.07101980
34	PLK2	1.06663169
35	INSRR	1.04089345
36	WNK1	1.00819248
37	ADRBK1	1.00089877
38	PKN1	0.95371683
39	PHKG1	0.95240794
40	PHKG2	0.95240794
41	OXSR1	0.92390895
42	TYRO3	0.90433461
43	DAPK2	0.89275190
44	SYK	0.87834539
45	PINK1	0.86619868
46	DAPK3	0.84881199
47	NLK	0.81993895
48	TEC	0.79651674
49	CSNK1G1	0.79617150
50	MAPK13	0.78754384
51	MAP2K7	0.76817522
52	SGK223	0.75086552
53	SGK494	0.75086552
54	LYN	0.72982323
55	LCK	0.71807811
56	MAPKAPK5	0.71469459
57	MAP2K2	0.70928526
58	CSNK2A2	0.70756106
59	MINK1	0.70684848
60	PIK3CA	0.68707731
61	PAK3	0.67280291
62	IKBKB	0.65282937
63	CDC7	0.64832269
64	ITK	0.64038029
65	DYRK1A	0.63519405
66	RPS6KA6	0.63068951
67	EPHB2	0.62421912
68	MARK3	0.61946441
69	PRKCA	0.60487671
70	OBSCN	0.60248084
71	STK11	0.59147388
72	NEK2	0.58842507
73	MAPK15	0.58802298
74	CAMK1	0.58764572
75	VRK2	0.58553865
76	ABL2	0.57855070
77	PRKACA	0.56913762
78	VRK1	0.56900848
79	TNK2	0.56609607
80	CSNK1A1	0.55957229
81	MYLK	0.55258161
82	CSNK2A1	0.52962909
83	CAMKK2	0.51966353
84	PRKCI	0.51579110
85	MAP3K11	0.49313512
86	PAK1	0.49121446
87	CDC42BPA	0.48322095
88	SGK2	0.46016177
89	TAF1	0.45081040
90	PDK1	0.44457307
91	NME1	0.40790745
92	MAP2K6	0.40545185
93	PRKCD	0.40327405
94	MUSK	0.39437120
95	CAMK2D	0.39437113
96	BTK	0.38073646
97	CAMK2A	0.36469056
98	ABL1	0.33919532
99	AURKA	0.33658882
100	MST4	0.32663781

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	5.70008751
2	Sulfur relay system_Homo sapiens_hsa04122	5.14659543
3	Asthma_Homo sapiens_hsa05310	3.38183898
4	Allograft rejection_Homo sapiens_hsa05330	2.75005283
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.67762722
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.63178246
7	Drug metabolism - other enzymes_Homo sapiens_hsa00983	2.38591496
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.37983720
9	Graft-versus-host disease_Homo sapiens_hsa05332	2.19046537
10	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.02029093
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.00452700
12	Parkinsons disease_Homo sapiens_hsa05012	1.87115817
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.85059002
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.72862068
15	Cardiac muscle contraction_Homo sapiens_hsa04260	1.61463039
16	Pentose phosphate pathway_Homo sapiens_hsa00030	1.61369133
17	Primary immunodeficiency_Homo sapiens_hsa05340	1.61324858
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.58297790
19	Nitrogen metabolism_Homo sapiens_hsa00910	1.48365304
20	Phototransduction_Homo sapiens_hsa04744	1.41501115
21	Alzheimers disease_Homo sapiens_hsa05010	1.40391958
22	Butanoate metabolism_Homo sapiens_hsa00650	1.37825141
23	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.36573824
24	Pyrimidine metabolism_Homo sapiens_hsa00240	1.33944327
25	Fat digestion and absorption_Homo sapiens_hsa04975	1.32583286
26	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.28721439
27	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.25494140
28	Tryptophan metabolism_Homo sapiens_hsa00380	1.22475661
29	Huntingtons disease_Homo sapiens_hsa05016	1.21214853
30	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.21148511
31	Nicotine addiction_Homo sapiens_hsa05033	1.20719248
32	Antigen processing and presentation_Homo sapiens_hsa04612	1.16816922
33	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.14705202
34	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.13828039
35	Olfactory transduction_Homo sapiens_hsa04740	1.12226137
36	Caffeine metabolism_Homo sapiens_hsa00232	1.11140967
37	Rheumatoid arthritis_Homo sapiens_hsa05323	1.08582581
38	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.06840539
39	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.04764216
40	Viral myocarditis_Homo sapiens_hsa05416	1.02673672
41	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.99573783
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94407382
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.94276782
44	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.93656775
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.92821498
46	Proteasome_Homo sapiens_hsa03050	0.90112164
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.89365378
48	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.87641380
49	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85487480
50	RNA degradation_Homo sapiens_hsa03018	0.85277563
51	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.84707052
52	One carbon pool by folate_Homo sapiens_hsa00670	0.84602767
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78428866
54	Propanoate metabolism_Homo sapiens_hsa00640	0.78289904
55	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.78231476
56	RNA polymerase_Homo sapiens_hsa03020	0.77362425
57	Ether lipid metabolism_Homo sapiens_hsa00565	0.76934136
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.76796576
59	Glycerolipid metabolism_Homo sapiens_hsa00561	0.74546963
60	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.73898506
61	Peroxisome_Homo sapiens_hsa04146	0.71293029
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70993826
63	Retinol metabolism_Homo sapiens_hsa00830	0.67132020
64	DNA replication_Homo sapiens_hsa03030	0.64101053
65	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.59807591
66	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59260586
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.58544486
68	Salivary secretion_Homo sapiens_hsa04970	0.57680232
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57403976
70	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.55797912
71	Taste transduction_Homo sapiens_hsa04742	0.55062403
72	Metabolic pathways_Homo sapiens_hsa01100	0.53956649
73	beta-Alanine metabolism_Homo sapiens_hsa00410	0.53816041
74	Purine metabolism_Homo sapiens_hsa00230	0.52102398
75	Insulin secretion_Homo sapiens_hsa04911	0.49967007
76	Leishmaniasis_Homo sapiens_hsa05140	0.48018150
77	Homologous recombination_Homo sapiens_hsa03440	0.45676616
78	Morphine addiction_Homo sapiens_hsa05032	0.42587778
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.42096890
80	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.41827449
81	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.37438619
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.36700597
83	Measles_Homo sapiens_hsa05162	0.36049098
84	Sulfur metabolism_Homo sapiens_hsa00920	0.35833746
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34654429
86	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.33559588
87	Serotonergic synapse_Homo sapiens_hsa04726	0.33475146
88	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.31506499
89	Gastric acid secretion_Homo sapiens_hsa04971	0.30228215
90	Circadian entrainment_Homo sapiens_hsa04713	0.29078373
91	Collecting duct acid secretion_Homo sapiens_hsa04966	0.27948923
92	Fatty acid degradation_Homo sapiens_hsa00071	0.27701829
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.26917569
94	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.24092444
95	Carbon metabolism_Homo sapiens_hsa01200	0.23848421
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.23347562
97	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.22772269
98	Arginine and proline metabolism_Homo sapiens_hsa00330	0.22488610
99	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.20365047
100	Basal transcription factors_Homo sapiens_hsa03022	0.19354557

RPL7AP7

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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