ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	6.91799835
2	translational termination (GO:0006415)	6.72563713
3	ribosomal small subunit biogenesis (GO:0042274)	6.62754373
4	ribosomal small subunit assembly (GO:0000028)	6.26452411
5	maturation of SSU-rRNA (GO:0030490)	5.73625103
6	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	5.58145433
7	cotranslational protein targeting to membrane (GO:0006613)	5.53880557
8	protein targeting to ER (GO:0045047)	5.49497520
9	translational elongation (GO:0006414)	5.41337978
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	5.27621636
11	cellular protein complex disassembly (GO:0043624)	5.24400208
12	protein localization to endoplasmic reticulum (GO:0070972)	5.16356099
13	viral life cycle (GO:0019058)	4.87704631
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	4.81486066
15	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	4.75868969
16	behavioral response to nicotine (GO:0035095)	4.57192387
17	protein complex disassembly (GO:0043241)	4.55031079
18	chaperone-mediated protein transport (GO:0072321)	4.53524610
19	tongue development (GO:0043586)	4.48895029
20	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	4.46657222
21	substrate-independent telencephalic tangential migration (GO:0021826)	4.46657222
22	macromolecular complex disassembly (GO:0032984)	4.36018472
23	nonmotile primary cilium assembly (GO:0035058)	4.32483794
24	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.29429476
25	base-excision repair, AP site formation (GO:0006285)	4.28339988
26	protein complex biogenesis (GO:0070271)	4.23492710
27	translational initiation (GO:0006413)	4.23356478
28	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.16010903
29	response to misfolded protein (GO:0051788)	4.04679597
30	negative regulation of leukocyte chemotaxis (GO:0002689)	4.04447022
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.92811810
32	NADH dehydrogenase complex assembly (GO:0010257)	3.92811810
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.92811810
34	pyrimidine nucleotide catabolic process (GO:0006244)	3.88569775
35	ribosomal large subunit biogenesis (GO:0042273)	3.87488104
36	head development (GO:0060322)	3.85337465
37	mitochondrial respiratory chain complex assembly (GO:0033108)	3.81943843
38	ATP synthesis coupled proton transport (GO:0015986)	3.80834508
39	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.80834508
40	protein targeting to membrane (GO:0006612)	3.63927444
41	axonemal dynein complex assembly (GO:0070286)	3.62262074
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.54668977
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.53454483
44	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.51599931
45	glycerophospholipid catabolic process (GO:0046475)	3.48467529
46	protein polyglutamylation (GO:0018095)	3.48056526
47	hypothalamus development (GO:0021854)	3.40282604
48	water-soluble vitamin biosynthetic process (GO:0042364)	3.40023223
49	cellular component biogenesis (GO:0044085)	3.38497239
50	motile cilium assembly (GO:0044458)	3.35199898
51	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.33869183
52	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.33057753
53	GTP biosynthetic process (GO:0006183)	3.31960020
54	cell proliferation in forebrain (GO:0021846)	3.30195414
55	adaptation of signaling pathway (GO:0023058)	3.29591690
56	ribonucleoprotein complex biogenesis (GO:0022613)	3.28422220
57	spinal cord association neuron differentiation (GO:0021527)	3.27404056
58	translation (GO:0006412)	3.16422231
59	mRNA catabolic process (GO:0006402)	3.14303207
60	neuron fate determination (GO:0048664)	3.04771324
61	regulation of mitochondrial translation (GO:0070129)	3.03396906
62	electron transport chain (GO:0022900)	3.01215832
63	parturition (GO:0007567)	2.96894260
64	respiratory electron transport chain (GO:0022904)	2.96811657
65	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.95334910
66	pyrimidine nucleobase catabolic process (GO:0006208)	2.94321043
67	regulation of cellular respiration (GO:0043457)	2.93879670
68	monoubiquitinated protein deubiquitination (GO:0035520)	2.93402221
69	UTP biosynthetic process (GO:0006228)	2.91500320
70	epithelial cilium movement (GO:0003351)	2.88795906
71	positive regulation of neuroblast proliferation (GO:0002052)	2.88694670
72	serotonin metabolic process (GO:0042428)	2.87714569
73	negative regulation of response to food (GO:0032096)	2.87623514
74	negative regulation of appetite (GO:0032099)	2.87623514
75	negative regulation of mast cell activation (GO:0033004)	2.87550711
76	dentate gyrus development (GO:0021542)	2.87424837
77	synaptic transmission, cholinergic (GO:0007271)	2.84722897
78	cardiovascular system development (GO:0072358)	2.83133666
79	CTP biosynthetic process (GO:0006241)	2.82799922
80	CTP metabolic process (GO:0046036)	2.82799922
81	cerebral cortex radially oriented cell migration (GO:0021799)	2.82612404
82	rRNA catabolic process (GO:0016075)	2.82472271
83	RNA catabolic process (GO:0006401)	2.78316227
84	regulation of cilium movement (GO:0003352)	2.77004665
85	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.75721767
86	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.75721767
87	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)	2.75625968
88	cilium movement (GO:0003341)	2.71714402
89	positive regulation of T cell apoptotic process (GO:0070234)	2.68744022
90	somite development (GO:0061053)	2.68112808
91	mannosylation (GO:0097502)	2.67261888
92	detection of light stimulus involved in visual perception (GO:0050908)	2.67200021
93	detection of light stimulus involved in sensory perception (GO:0050962)	2.67200021
94	thalamus development (GO:0021794)	2.63569298
95	UTP metabolic process (GO:0046051)	2.61956162
96	intraciliary transport (GO:0042073)	2.61723732
97	limb development (GO:0060173)	2.61116938
98	appendage development (GO:0048736)	2.61116938
99	xenobiotic catabolic process (GO:0042178)	2.59836797
100	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.59245634

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.54745296
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.82344435
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.71370544
4	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.64583122
5	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.49107223
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.42524124
7	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.32837518
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17493403
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.16621478
10	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.12144230
11	IRF1_19129219_ChIP-ChIP_H3396_Human	2.10982186
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.03404849
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.01419936
14	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.93971636
15	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.89739487
16	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.85190172
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.75640398
18	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.75347160
19	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.72442630
20	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.70977701
21	GBX2_23144817_ChIP-Seq_PC3_Human	1.70532530
22	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.59688602
23	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58038672
24	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.54669652
25	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.54669652
26	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.53119606
27	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52106343
28	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.51871814
29	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.50537678
30	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.44976251
31	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.44523369
32	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.44232154
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.43530214
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.42169565
35	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.41218398
36	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.39007964
37	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.38494782
38	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.37277927
39	REST_21632747_ChIP-Seq_MESCs_Mouse	1.35009193
40	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.33770256
41	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.32226850
42	TTF2_22483619_ChIP-Seq_HELA_Human	1.32203366
43	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.29315710
44	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.29268511
45	ERA_21632823_ChIP-Seq_H3396_Human	1.28898098
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.28681264
47	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.27175008
48	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.26891210
49	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.26564821
50	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.25618583
51	CTCF_27219007_Chip-Seq_Bcells_Human	1.25458435
52	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.24440577
53	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23460233
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23226771
55	NANOG_20526341_ChIP-Seq_ESCs_Human	1.22558100
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.21228277
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20897588
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.20897588
59	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.20646335
60	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.20078622
61	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19944997
62	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.19449276
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19320507
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.18234378
65	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16815712
66	NCOR_22424771_ChIP-Seq_293T_Human	1.12861564
67	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.08004856
68	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.06043949
69	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.05118952
70	EWS_26573619_Chip-Seq_HEK293_Human	1.04906483
71	P53_21459846_ChIP-Seq_SAOS-2_Human	1.04335561
72	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.03869152
73	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.03136500
74	BCAT_22108803_ChIP-Seq_LS180_Human	1.02443391
75	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.01875222
76	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.01686592
77	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	1.00761901
78	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.00587246
79	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.00544181
80	ELK1_19687146_ChIP-ChIP_HELA_Human	1.00022238
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.00018408
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99960326
83	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.99268679
84	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98648666
85	VDR_22108803_ChIP-Seq_LS180_Human	0.98269325
86	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98076785
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.97901904
88	RING1B_27294783_Chip-Seq_ESCs_Mouse	0.97799431
89	TP53_16413492_ChIP-PET_HCT116_Human	0.97396720
90	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.95487316
91	POU5F1_16518401_ChIP-PET_MESCs_Mouse	0.95212519
92	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.94698597
93	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.94434768
94	FUS_26573619_Chip-Seq_HEK293_Human	0.94013708
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.93195226
96	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.91118822
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.89931912
98	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.89507318
99	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.89279680
100	XRN2_22483619_ChIP-Seq_HELA_Human	0.88332870

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.93504078
2	MP0009379_abnormal_foot_pigmentation	4.91859287
3	MP0003122_maternal_imprinting	3.38908597
4	MP0003646_muscle_fatigue	3.15575228
5	MP0008789_abnormal_olfactory_epithelium	3.10182673
6	MP0005379_endocrine/exocrine_gland_phen	3.02699148
7	MP0002163_abnormal_gland_morphology	2.73278947
8	MP0010030_abnormal_orbit_morphology	2.68923683
9	MP0003136_yellow_coat_color	2.62597345
10	MP0003011_delayed_dark_adaptation	2.58723537
11	MP0002653_abnormal_ependyma_morphology	2.51965697
12	MP0001293_anophthalmia	2.45538109
13	MP0005394_taste/olfaction_phenotype	2.40148411
14	MP0005499_abnormal_olfactory_system	2.40148411
15	MP0005377_hearing/vestibular/ear_phenot	2.29838624
16	MP0003878_abnormal_ear_physiology	2.29838624
17	MP0004742_abnormal_vestibular_system	2.22206994
18	MP0004142_abnormal_muscle_tone	2.15966768
19	MP0003121_genomic_imprinting	1.90701529
20	MP0001485_abnormal_pinna_reflex	1.86547488
21	MP0002736_abnormal_nociception_after	1.83428565
22	MP0002102_abnormal_ear_morphology	1.82050046
23	MP0001348_abnormal_lacrimal_gland	1.75594494
24	MP0002837_dystrophic_cardiac_calcinosis	1.70384288
25	MP0005551_abnormal_eye_electrophysiolog	1.67917827
26	MP0004885_abnormal_endolymph	1.67688917
27	MP0000049_abnormal_middle_ear	1.66951935
28	MP0003890_abnormal_embryonic-extraembry	1.60843741
29	MP0000778_abnormal_nervous_system	1.55316604
30	MP0002938_white_spotting	1.54219726
31	MP0000372_irregular_coat_pigmentation	1.51182373
32	MP0000566_synostosis	1.50609482
33	MP0003123_paternal_imprinting	1.49447066
34	MP0002233_abnormal_nose_morphology	1.49078640
35	MP0002638_abnormal_pupillary_reflex	1.44984096
36	MP0001968_abnormal_touch/_nociception	1.44480317
37	MP0008872_abnormal_physiological_respon	1.44089037
38	MP0000026_abnormal_inner_ear	1.33734403
39	MP0008875_abnormal_xenobiotic_pharmacok	1.33441790
40	MP0001529_abnormal_vocalization	1.26105369
41	MP0003879_abnormal_hair_cell	1.23881946
42	MP0003787_abnormal_imprinting	1.23524504
43	MP0009046_muscle_twitch	1.21937094
44	MP0002277_abnormal_respiratory_mucosa	1.21458038
45	MP0002272_abnormal_nervous_system	1.21028898
46	MP0000631_abnormal_neuroendocrine_gland	1.15613401
47	MP0003119_abnormal_digestive_system	1.14761235
48	MP0003937_abnormal_limbs/digits/tail_de	1.14305990
49	MP0002092_abnormal_eye_morphology	1.12308417
50	MP0005167_abnormal_blood-brain_barrier	1.09868260
51	MP0001984_abnormal_olfaction	1.09122268
52	MP0002234_abnormal_pharynx_morphology	1.07232960
53	MP0008877_abnormal_DNA_methylation	1.06743310
54	MP0010368_abnormal_lymphatic_system	1.05674409
55	MP0005195_abnormal_posterior_eye	1.04304904
56	MP0005391_vision/eye_phenotype	1.03951829
57	MP0002557_abnormal_social/conspecific_i	1.03676944
58	MP0004133_heterotaxia	1.01485790
59	MP0001963_abnormal_hearing_physiology	1.01145789
60	MP0001905_abnormal_dopamine_level	1.00346991
61	MP0009053_abnormal_anal_canal	0.99517225
62	MP0009745_abnormal_behavioral_response	0.98493923
63	MP0000383_abnormal_hair_follicle	0.96951473
64	MP0001286_abnormal_eye_development	0.95545796
65	MP0003942_abnormal_urinary_system	0.93965117
66	MP0003755_abnormal_palate_morphology	0.92700827
67	MP0002160_abnormal_reproductive_system	0.91941507
68	MP0000647_abnormal_sebaceous_gland	0.91494667
69	MP0003938_abnormal_ear_development	0.86892860
70	MP0008775_abnormal_heart_ventricle	0.86562491
71	MP0005645_abnormal_hypothalamus_physiol	0.86299944
72	MP0001502_abnormal_circadian_rhythm	0.85389839
73	MP0002249_abnormal_larynx_morphology	0.85344080
74	MP0005389_reproductive_system_phenotype	0.85290245
75	MP0002752_abnormal_somatic_nervous	0.85003736
76	MP0003186_abnormal_redox_activity	0.84760211
77	MP0001727_abnormal_embryo_implantation	0.84326219
78	MP0001486_abnormal_startle_reflex	0.83891705
79	MP0006276_abnormal_autonomic_nervous	0.83058285
80	MP0001440_abnormal_grooming_behavior	0.82734208
81	MP0002184_abnormal_innervation	0.82354491
82	MP0000427_abnormal_hair_cycle	0.80463588
83	MP0003567_abnormal_fetal_cardiomyocyte	0.79375435
84	MP0004130_abnormal_muscle_cell	0.79071397
85	MP0000955_abnormal_spinal_cord	0.78183841
86	MP0003880_abnormal_central_pattern	0.77669110
87	MP0002067_abnormal_sensory_capabilities	0.76843351
88	MP0002734_abnormal_mechanical_nocicepti	0.76532808
89	MP0002697_abnormal_eye_size	0.76442294
90	MP0000428_abnormal_craniofacial_morphol	0.76122556
91	MP0005253_abnormal_eye_physiology	0.75988228
92	MP0009384_cardiac_valve_regurgitation	0.75572366
93	MP0004019_abnormal_vitamin_homeostasis	0.75500492
94	MP0002733_abnormal_thermal_nociception	0.74380718
95	MP0002572_abnormal_emotion/affect_behav	0.74283566
96	MP0000613_abnormal_salivary_gland	0.73748112
97	MP0001986_abnormal_taste_sensitivity	0.71994685
98	MP0001299_abnormal_eye_distance/	0.70384090
99	MP0001970_abnormal_pain_threshold	0.69873054
100	MP0006072_abnormal_retinal_apoptosis	0.68776731

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	5.74606242
2	Septo-optic dysplasia (HP:0100842)	4.55406336
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.16908355
4	Amblyopia (HP:0000646)	3.70661840
5	Acute necrotizing encephalopathy (HP:0006965)	3.41759763
6	Optic nerve hypoplasia (HP:0000609)	3.37176597
7	Aplasia/Hypoplasia of the sacrum (HP:0008517)	3.32249829
8	Anophthalmia (HP:0000528)	3.27577258
9	Colon cancer (HP:0003003)	3.24138342
10	Abnormality of midbrain morphology (HP:0002418)	3.14086273
11	Molar tooth sign on MRI (HP:0002419)	3.14086273
12	Mitochondrial inheritance (HP:0001427)	3.11067789
13	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	3.05370353
14	Medial flaring of the eyebrow (HP:0010747)	3.01962525
15	Cerebellar dysplasia (HP:0007033)	2.97093927
16	Acute encephalopathy (HP:0006846)	2.94841670
17	Maternal diabetes (HP:0009800)	2.93928085
18	Abnormal ciliary motility (HP:0012262)	2.91577572
19	Abnormal number of erythroid precursors (HP:0012131)	2.89617240
20	Absent/shortened dynein arms (HP:0200106)	2.88935099
21	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.88935099
22	Abnormal mitochondria in muscle tissue (HP:0008316)	2.86969546
23	Increased hepatocellular lipid droplets (HP:0006565)	2.86112661
24	Type II lissencephaly (HP:0007260)	2.86004972
25	Pancreatic fibrosis (HP:0100732)	2.83039246
26	Rib fusion (HP:0000902)	2.82099098
27	Lipid accumulation in hepatocytes (HP:0006561)	2.80151499
28	Macrocytic anemia (HP:0001972)	2.77309765
29	Progressive macrocephaly (HP:0004481)	2.75908708
30	Hepatocellular necrosis (HP:0001404)	2.75587480
31	Hyperglycinemia (HP:0002154)	2.73790743
32	Neoplasm of the adrenal cortex (HP:0100641)	2.68448745
33	Gait imbalance (HP:0002141)	2.67514499
34	Congenital primary aphakia (HP:0007707)	2.62347981
35	Absent septum pellucidum (HP:0001331)	2.62319148
36	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.59790000
37	Increased CSF lactate (HP:0002490)	2.58361545
38	Abnormal respiratory epithelium morphology (HP:0012253)	2.58209841
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.58209841
40	Cutaneous melanoma (HP:0012056)	2.54481191
41	Abnormal respiratory motile cilium physiology (HP:0012261)	2.53071452
42	Occipital encephalocele (HP:0002085)	2.52558320
43	Abnormality of the aortic arch (HP:0012303)	2.51523095
44	Chronic hepatic failure (HP:0100626)	2.49231162
45	Abnormality of the parathyroid morphology (HP:0011766)	2.46777622
46	Retinal atrophy (HP:0001105)	2.44541077
47	Congenital stationary night blindness (HP:0007642)	2.44154761
48	Renal Fanconi syndrome (HP:0001994)	2.38278020
49	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.36025575
50	Supernumerary spleens (HP:0009799)	2.35017010
51	Abnormality of DNA repair (HP:0003254)	2.34260378
52	Pendular nystagmus (HP:0012043)	2.29254751
53	Cerebral edema (HP:0002181)	2.29155580
54	Nephrogenic diabetes insipidus (HP:0009806)	2.28839945
55	Hepatic necrosis (HP:0002605)	2.28383542
56	Abnormal rod and cone electroretinograms (HP:0008323)	2.27894856
57	Sclerocornea (HP:0000647)	2.26522086
58	Ectopic kidney (HP:0000086)	2.25272537
59	Pallor (HP:0000980)	2.23232783
60	Asplenia (HP:0001746)	2.21914406
61	Vaginal atresia (HP:0000148)	2.20284269
62	Stenosis of the external auditory canal (HP:0000402)	2.19718524
63	Absent thumb (HP:0009777)	2.17793816
64	Genital tract atresia (HP:0001827)	2.12631047
65	Growth hormone deficiency (HP:0000824)	2.09768734
66	Abnormality of the labia minora (HP:0012880)	2.08568715
67	Hypomagnesemia (HP:0002917)	2.07803085
68	Abnormal drinking behavior (HP:0030082)	2.07434182
69	Polydipsia (HP:0001959)	2.07434182
70	Pancreatic cysts (HP:0001737)	2.07409192
71	Abnormal pancreas size (HP:0012094)	2.06015150
72	True hermaphroditism (HP:0010459)	2.05152440
73	Polyuria (HP:0000103)	2.02520260
74	Poor coordination (HP:0002370)	2.02305029
75	Concave nail (HP:0001598)	2.00492463
76	Respiratory difficulties (HP:0002880)	1.99723845
77	Partial duplication of thumb phalanx (HP:0009944)	1.99664052
78	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.95255919
79	11 pairs of ribs (HP:0000878)	1.92146362
80	Annular pancreas (HP:0001734)	1.89764142
81	Abnormality of magnesium homeostasis (HP:0004921)	1.84579777
82	Nephronophthisis (HP:0000090)	1.83736389
83	Optic disc pallor (HP:0000543)	1.81891054
84	Depressed nasal ridge (HP:0000457)	1.81845626
85	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.81537063
86	Abnormality of serine family amino acid metabolism (HP:0010894)	1.81207441
87	Abnormality of glycine metabolism (HP:0010895)	1.81207441
88	Bilateral microphthalmos (HP:0007633)	1.80283128
89	Microretrognathia (HP:0000308)	1.79280804
90	Oligodactyly (HP:0012165)	1.79020706
91	Abnormality of renal resorption (HP:0011038)	1.77657602
92	Postaxial foot polydactyly (HP:0001830)	1.77588452
93	Renal dysplasia (HP:0000110)	1.77511673
94	Missing ribs (HP:0000921)	1.77408477
95	Bifid tongue (HP:0010297)	1.76171716
96	Anterior segment dysgenesis (HP:0007700)	1.75309690
97	Abnormality of the septum pellucidum (HP:0007375)	1.75117777
98	Abnormality of the metopic suture (HP:0005556)	1.71478890
99	Polyphagia (HP:0002591)	1.70880000
100	Optic nerve coloboma (HP:0000588)	1.70613481

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	BRSK2	6.00634302
2	WEE1	4.04927994
3	BRSK1	3.32277683
4	STK16	3.12979809
5	WNK4	2.93514171
6	TIE1	2.78481383
7	VRK2	2.73393441
8	FRK	2.55459295
9	ZAK	2.37036031
10	MAP4K2	2.34739141
11	EPHB2	2.28324133
12	TAF1	2.22743408
13	EPHA4	2.08194159
14	DYRK2	2.07157946
15	MAP3K11	1.91070614
16	GRK1	1.71185264
17	ADRBK2	1.69351443
18	WNK1	1.58774093
19	BMPR1B	1.57564178
20	CAMKK2	1.56689134
21	CASK	1.55796806
22	NUAK1	1.53238511
23	PINK1	1.52356200
24	MAP3K12	1.50787695
25	WNK3	1.47304072
26	SMG1	1.26797326
27	LRRK2	1.23049643
28	PBK	1.19953997
29	BCKDK	1.17140488
30	CDC7	1.15910028
31	MAP3K10	1.10495969
32	MAP3K13	1.08894280
33	TAOK3	1.08576946
34	STK39	1.02632603
35	AURKA	1.02453153
36	MAP2K4	0.99885263
37	MAP2K7	0.97142217
38	TYRO3	0.96229833
39	DAPK3	0.92586586
40	CDK19	0.91000996
41	CAMK1D	0.88094076
42	CAMK1	0.81932429
43	GRK5	0.81886794
44	STK11	0.80419208
45	MAP3K4	0.79943299
46	PLK1	0.77908831
47	PRKCG	0.77002654
48	CAMK1G	0.76859405
49	CSNK1G2	0.76513446
50	NEK1	0.73663488
51	MAPKAPK5	0.73291759
52	ACVR1B	0.73024294
53	MKNK2	0.71344045
54	NEK2	0.70749606
55	PNCK	0.69921991
56	MAPK13	0.68659325
57	CAMK4	0.68297325
58	KDR	0.66265825
59	CSNK1G1	0.65790041
60	PLK3	0.62398690
61	ADRBK1	0.61116053
62	PIK3CA	0.60435499
63	CSNK1G3	0.58607902
64	INSRR	0.58112674
65	TNIK	0.57631359
66	LIMK1	0.57351286
67	MAPK15	0.56962993
68	NTRK2	0.56916250
69	PLK4	0.55801617
70	PLK2	0.55264245
71	VRK1	0.55073174
72	TGFBR1	0.53420455
73	TEC	0.51457795
74	PRKCI	0.50637287
75	AURKB	0.43446682
76	CAMKK1	0.43317080
77	CSNK1A1L	0.42915992
78	PRKCQ	0.40978268
79	PRKCZ	0.39847231
80	KSR1	0.39310247
81	RPS6KA6	0.39155869
82	CHEK2	0.38868777
83	OXSR1	0.38325977
84	TLK1	0.38103429
85	RPS6KA5	0.37602885
86	MAP3K7	0.36895852
87	PRKACA	0.36560108
88	CDK14	0.35674436
89	PASK	0.34062530
90	HIPK2	0.34042788
91	UHMK1	0.33958589
92	DYRK3	0.33134922
93	CSNK1A1	0.32051269
94	CSNK2A2	0.31129972
95	CDK5	0.30637949
96	PRKCE	0.27628688
97	CDK11A	0.27340420
98	MAP2K2	0.26282653
99	PRKAA2	0.25657033
100	PRKCA	0.25611124

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	6.19681046
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.94845645
3	Parkinsons disease_Homo sapiens_hsa05012	3.24676450
4	Huntingtons disease_Homo sapiens_hsa05016	2.55186313
5	Cardiac muscle contraction_Homo sapiens_hsa04260	2.51678684
6	Sulfur relay system_Homo sapiens_hsa04122	2.36564516
7	RNA polymerase_Homo sapiens_hsa03020	2.32809235
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.28926118
9	Alzheimers disease_Homo sapiens_hsa05010	2.27910701
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.03243358
11	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.01516437
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.77047519
13	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.68983180
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65402529
15	Phototransduction_Homo sapiens_hsa04744	1.63031298
16	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.60954192
17	Steroid biosynthesis_Homo sapiens_hsa00100	1.56817950
18	Regulation of autophagy_Homo sapiens_hsa04140	1.54625754
19	Fatty acid degradation_Homo sapiens_hsa00071	1.52088716
20	Nicotine addiction_Homo sapiens_hsa05033	1.51054817
21	Basal cell carcinoma_Homo sapiens_hsa05217	1.47765742
22	Butanoate metabolism_Homo sapiens_hsa00650	1.47348872
23	Protein export_Homo sapiens_hsa03060	1.46383343
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.42878202
25	Propanoate metabolism_Homo sapiens_hsa00640	1.35734761
26	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.30191891
27	RNA degradation_Homo sapiens_hsa03018	1.29982661
28	Basal transcription factors_Homo sapiens_hsa03022	1.29744591
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.29014296
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23010431
31	Homologous recombination_Homo sapiens_hsa03440	1.21600412
32	Fanconi anemia pathway_Homo sapiens_hsa03460	1.18488867
33	Retinol metabolism_Homo sapiens_hsa00830	1.17401690
34	Nucleotide excision repair_Homo sapiens_hsa03420	1.13952412
35	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13269535
36	Peroxisome_Homo sapiens_hsa04146	1.12317819
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08868021
38	Ether lipid metabolism_Homo sapiens_hsa00565	1.05931930
39	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.05030901
40	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.04951883
41	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02669902
42	Fat digestion and absorption_Homo sapiens_hsa04975	1.00877622
43	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.00492902
44	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.99067167
45	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95900776
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.94457666
47	Pyrimidine metabolism_Homo sapiens_hsa00240	0.93152104
48	Proteasome_Homo sapiens_hsa03050	0.92609415
49	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.90840019
50	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.90649231
51	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.89580931
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.88708312
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85999081
54	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.85060025
55	Fatty acid metabolism_Homo sapiens_hsa01212	0.81008932
56	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.76386238
57	Metabolic pathways_Homo sapiens_hsa01100	0.75679352
58	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.68733482
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.63862815
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62665335
61	Purine metabolism_Homo sapiens_hsa00230	0.60992810
62	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.59297760
63	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.56075337
64	Base excision repair_Homo sapiens_hsa03410	0.54241583
65	Hippo signaling pathway_Homo sapiens_hsa04390	0.52167119
66	Morphine addiction_Homo sapiens_hsa05032	0.52059570
67	Arginine and proline metabolism_Homo sapiens_hsa00330	0.51692176
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.50799324
69	Notch signaling pathway_Homo sapiens_hsa04330	0.49869667
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49600626
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49253767
72	Olfactory transduction_Homo sapiens_hsa04740	0.46763399
73	Glutamatergic synapse_Homo sapiens_hsa04724	0.46191972
74	Caffeine metabolism_Homo sapiens_hsa00232	0.45248070
75	RNA transport_Homo sapiens_hsa03013	0.44459850
76	Insulin secretion_Homo sapiens_hsa04911	0.42819129
77	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40411893
78	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.39747546
79	Fatty acid elongation_Homo sapiens_hsa00062	0.39604632
80	Mismatch repair_Homo sapiens_hsa03430	0.39516722
81	Sulfur metabolism_Homo sapiens_hsa00920	0.39161135
82	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.38826034
83	Mineral absorption_Homo sapiens_hsa04978	0.38050684
84	Serotonergic synapse_Homo sapiens_hsa04726	0.37766266
85	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36204795
86	Glutathione metabolism_Homo sapiens_hsa00480	0.35964847
87	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.35707202
88	ABC transporters_Homo sapiens_hsa02010	0.34629773
89	Wnt signaling pathway_Homo sapiens_hsa04310	0.33724916
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.33419344
91	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.33322388
92	Pyruvate metabolism_Homo sapiens_hsa00620	0.33280994
93	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.32202235
94	Tyrosine metabolism_Homo sapiens_hsa00350	0.32103626
95	Axon guidance_Homo sapiens_hsa04360	0.31879151
96	Taste transduction_Homo sapiens_hsa04742	0.30889982
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.30604223
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.29089651
99	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.29048250
100	PPAR signaling pathway_Homo sapiens_hsa03320	0.28837140

RPL7AP71

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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