ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	8.69704634
2	ribosomal small subunit biogenesis (GO:0042274)	8.44461334
3	translational termination (GO:0006415)	8.37555841
4	maturation of SSU-rRNA (GO:0030490)	8.21049432
5	ribosomal small subunit assembly (GO:0000028)	7.65031777
6	translational elongation (GO:0006414)	6.88940364
7	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	6.84252319
8	cotranslational protein targeting to membrane (GO:0006613)	6.75933762
9	protein targeting to ER (GO:0045047)	6.72999757
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	6.47762043
11	cellular protein complex disassembly (GO:0043624)	6.39193407
12	viral life cycle (GO:0019058)	6.31183500
13	protein localization to endoplasmic reticulum (GO:0070972)	6.28217555
14	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.17993349
15	behavioral response to nicotine (GO:0035095)	5.50158424
16	protein complex disassembly (GO:0043241)	5.45530968
17	translational initiation (GO:0006413)	5.30818581
18	macromolecular complex disassembly (GO:0032984)	5.16493281
19	substrate-independent telencephalic tangential migration (GO:0021826)	5.03616692
20	substrate-independent telencephalic tangential interneuron migration (GO:0021843)	5.03616692
21	chaperone-mediated protein transport (GO:0072321)	4.85312996
22	ribosomal large subunit biogenesis (GO:0042273)	4.79334471
23	protein neddylation (GO:0045116)	4.75123690
24	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.59591697
25	ATP synthesis coupled proton transport (GO:0015986)	4.59591697
26	protein targeting to membrane (GO:0006612)	4.55293353
27	nonmotile primary cilium assembly (GO:0035058)	4.49457645
28	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.29047270
29	translation (GO:0006412)	4.09145543
30	mRNA catabolic process (GO:0006402)	4.07510798
31	tongue development (GO:0043586)	3.97515947
32	cell proliferation in forebrain (GO:0021846)	3.95680001
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.94478984
34	ribonucleoprotein complex biogenesis (GO:0022613)	3.87407705
35	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.77976852
36	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.66483207
37	positive regulation of T cell apoptotic process (GO:0070234)	3.64391543
38	RNA catabolic process (GO:0006401)	3.62197829
39	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.53008835
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.53008835
41	NADH dehydrogenase complex assembly (GO:0010257)	3.53008835
42	cellular component biogenesis (GO:0044085)	3.51568705
43	water-soluble vitamin biosynthetic process (GO:0042364)	3.45395065
44	GTP biosynthetic process (GO:0006183)	3.34946699
45	protein complex biogenesis (GO:0070271)	3.28583570
46	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.26383665
47	central nervous system myelination (GO:0022010)	3.14384011
48	axon ensheathment in central nervous system (GO:0032291)	3.14384011
49	respiratory electron transport chain (GO:0022904)	3.07901446
50	electron transport chain (GO:0022900)	3.07676387
51	negative regulation of T cell differentiation in thymus (GO:0033085)	3.05458856
52	establishment of protein localization to membrane (GO:0090150)	3.05366182
53	somite development (GO:0061053)	3.03909738
54	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.03358104
55	cardiovascular system development (GO:0072358)	3.02008603
56	mitochondrial respiratory chain complex assembly (GO:0033108)	2.96068483
57	protein targeting (GO:0006605)	2.93629093
58	establishment of mitochondrion localization (GO:0051654)	2.92567674
59	regulation of cilium movement (GO:0003352)	2.91735872
60	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.89689548
61	epithelial cilium movement (GO:0003351)	2.89447808
62	protein polyglutamylation (GO:0018095)	2.89020586
63	ubiquinone biosynthetic process (GO:0006744)	2.87211674
64	pyrimidine nucleobase catabolic process (GO:0006208)	2.86896737
65	myoblast migration (GO:0051451)	2.86823306
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.86720450
67	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.86720450
68	kidney morphogenesis (GO:0060993)	2.86216585
69	UTP biosynthetic process (GO:0006228)	2.82869410
70	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.80960035
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.79405530
72	establishment of protein localization to organelle (GO:0072594)	2.78141566
73	mitochondrion transport along microtubule (GO:0047497)	2.77902131
74	establishment of mitochondrion localization, microtubule-mediated (GO:0034643)	2.77902131
75	parturition (GO:0007567)	2.76134274
76	ATP biosynthetic process (GO:0006754)	2.75397816
77	auditory receptor cell differentiation (GO:0042491)	2.74111823
78	positive regulation of lymphocyte apoptotic process (GO:0070230)	2.68755561
79	rRNA processing (GO:0006364)	2.68642448
80	pyrimidine nucleotide catabolic process (GO:0006244)	2.68447118
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.67490552
82	rRNA metabolic process (GO:0016072)	2.66154807
83	negative regulation of telomere maintenance (GO:0032205)	2.65896921
84	positive regulation of respiratory burst (GO:0060267)	2.65682819
85	positive regulation of protein homooligomerization (GO:0032464)	2.64456129
86	axonemal dynein complex assembly (GO:0070286)	2.63543719
87	neuron fate determination (GO:0048664)	2.62711857
88	UTP metabolic process (GO:0046051)	2.62168026
89	ubiquinone metabolic process (GO:0006743)	2.57597751
90	hydrogen ion transmembrane transport (GO:1902600)	2.57042089
91	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.52804541
92	thalamus development (GO:0021794)	2.52672587
93	intraciliary transport (GO:0042073)	2.50987686
94	synaptic transmission, cholinergic (GO:0007271)	2.50638967
95	hypothalamus development (GO:0021854)	2.50243715
96	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.49334178
97	axonal fasciculation (GO:0007413)	2.47832220
98	pattern specification involved in kidney development (GO:0061004)	2.46739559
99	protein localization to membrane (GO:0072657)	2.45545281
100	head development (GO:0060322)	2.44747288

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	6.21629059
2	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.80053614
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.94770796
4	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59294188
5	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.53691739
6	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.39576705
7	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.31670068
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.27400906
9	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.23111534
10	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.11798971
11	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.05458199
12	IRF1_19129219_ChIP-ChIP_H3396_Human	2.02886289
13	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.97916576
14	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.96614930
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.95736589
16	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.94392100
17	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.91722138
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.91547822
19	ZNF274_21170338_ChIP-Seq_K562_Hela	1.87035483
20	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.80619511
21	VDR_22108803_ChIP-Seq_LS180_Human	1.77383939
22	TTF2_22483619_ChIP-Seq_HELA_Human	1.71678271
23	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.70893587
24	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.69478616
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.66465870
26	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66368307
27	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.63755565
28	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.59705718
29	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.58744977
30	MYC_18940864_ChIP-ChIP_HL60_Human	1.58094332
31	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.57069151
32	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.56238129
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.52958248
34	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.52917207
35	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.48654810
36	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46532856
37	XRN2_22483619_ChIP-Seq_HELA_Human	1.43237382
38	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.41650097
39	RNF2_27304074_Chip-Seq_NSC_Mouse	1.38242196
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35721302
41	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.35303776
42	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.35180883
43	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.33484363
44	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.33484363
45	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.32755638
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.32602387
47	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.31089999
48	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.30797985
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.29513587
50	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28749147
51	TP53_22573176_ChIP-Seq_HFKS_Human	1.27584141
52	GABP_19822575_ChIP-Seq_HepG2_Human	1.26821972
53	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.26472561
54	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.26305117
55	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25031539
56	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.24624515
57	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.19106107
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.16976420
59	FOXP3_21729870_ChIP-Seq_TREG_Human	1.14672172
60	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.14410657
61	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.13301916
62	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.12902098
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.12578549
64	ERA_21632823_ChIP-Seq_H3396_Human	1.12452805
65	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.12324901
66	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.12084647
67	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.11708197
68	VDR_23849224_ChIP-Seq_CD4+_Human	1.11557717
69	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.08910378
70	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.08181375
71	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.07485389
72	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.06537219
73	TAF2_19829295_ChIP-Seq_ESCs_Human	1.06149208
74	NANOG_20526341_ChIP-Seq_ESCs_Human	1.05454680
75	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.05373374
76	EWS_26573619_Chip-Seq_HEK293_Human	1.05222770
77	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.04766235
78	ELK1_19687146_ChIP-ChIP_HELA_Human	1.04157839
79	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.03725553
80	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.02803008
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.02691794
82	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.02086341
83	MYC_19829295_ChIP-Seq_ESCs_Human	1.00777356
84	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.99707273
85	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.99293509
86	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.98208012
87	OLIG2_26023283_ChIP-Seq_AINV15_Mouse	0.96128748
88	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95775624
89	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.95279002
90	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.95117383
91	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.95041067
92	CTCF_27219007_Chip-Seq_Bcells_Human	0.94548983
93	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.94517411
94	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.94280301
95	ELF1_17652178_ChIP-ChIP_JURKAT_Human	0.91891920
96	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.91538056
97	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.91347561
98	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.89900251
99	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.89702084
100	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.89164227

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	6.11135880
2	MP0006292_abnormal_olfactory_placode	5.34123232
3	MP0003787_abnormal_imprinting	3.11659411
4	MP0008789_abnormal_olfactory_epithelium	3.00515438
5	MP0002653_abnormal_ependyma_morphology	2.66561967
6	MP0003123_paternal_imprinting	2.66080183
7	MP0003122_maternal_imprinting	2.64887020
8	MP0010030_abnormal_orbit_morphology	2.53489324
9	MP0005394_taste/olfaction_phenotype	2.52669104
10	MP0005499_abnormal_olfactory_system	2.52669104
11	MP0008877_abnormal_DNA_methylation	2.41358710
12	MP0001293_anophthalmia	2.30875009
13	MP0004742_abnormal_vestibular_system	2.22967813
14	MP0004142_abnormal_muscle_tone	2.22076340
15	MP0001485_abnormal_pinna_reflex	2.13765506
16	MP0000778_abnormal_nervous_system	2.11694534
17	MP0003121_genomic_imprinting	1.99410601
18	MP0000049_abnormal_middle_ear	1.94582598
19	MP0003878_abnormal_ear_physiology	1.93764315
20	MP0005377_hearing/vestibular/ear_phenot	1.93764315
21	MP0002163_abnormal_gland_morphology	1.91139926
22	MP0005423_abnormal_somatic_nervous	1.85401757
23	MP0003136_yellow_coat_color	1.78584621
24	MP0002938_white_spotting	1.72994059
25	MP0005646_abnormal_pituitary_gland	1.71751717
26	MP0001348_abnormal_lacrimal_gland	1.69974007
27	MP0002102_abnormal_ear_morphology	1.62508333
28	MP0004885_abnormal_endolymph	1.58763339
29	MP0006276_abnormal_autonomic_nervous	1.57680180
30	MP0003646_muscle_fatigue	1.56889913
31	MP0001529_abnormal_vocalization	1.52807747
32	MP0003880_abnormal_central_pattern	1.51334193
33	MP0000631_abnormal_neuroendocrine_gland	1.50427265
34	MP0001984_abnormal_olfaction	1.39457520
35	MP0003938_abnormal_ear_development	1.36156187
36	MP0002272_abnormal_nervous_system	1.35899207
37	MP0001968_abnormal_touch/_nociception	1.31290727
38	MP0005379_endocrine/exocrine_gland_phen	1.30760289
39	MP0002638_abnormal_pupillary_reflex	1.30043646
40	MP0000566_synostosis	1.22889531
41	MP0005551_abnormal_eye_electrophysiolog	1.22333332
42	MP0000955_abnormal_spinal_cord	1.21923175
43	MP0002557_abnormal_social/conspecific_i	1.21870151
44	MP0005195_abnormal_posterior_eye	1.21097425
45	MP0009745_abnormal_behavioral_response	1.18381164
46	MP0000026_abnormal_inner_ear	1.16775227
47	MP0004133_heterotaxia	1.13220591
48	MP0002736_abnormal_nociception_after	1.13213934
49	MP0002837_dystrophic_cardiac_calcinosis	1.12895954
50	MP0002095_abnormal_skin_pigmentation	1.12280184
51	MP0009046_muscle_twitch	1.09351161
52	MP0002233_abnormal_nose_morphology	1.07959406
53	MP0002184_abnormal_innervation	1.05002843
54	MP0002752_abnormal_somatic_nervous	1.04582536
55	MP0002160_abnormal_reproductive_system	1.03612578
56	MP0001286_abnormal_eye_development	1.02958961
57	MP0002876_abnormal_thyroid_physiology	1.01859444
58	MP0001986_abnormal_taste_sensitivity	1.00554191
59	MP0001486_abnormal_startle_reflex	0.99692934
60	MP0009053_abnormal_anal_canal	0.99498546
61	MP0002572_abnormal_emotion/affect_behav	0.99371342
62	MP0003186_abnormal_redox_activity	0.98222386
63	MP0001905_abnormal_dopamine_level	0.96945416
64	MP0002063_abnormal_learning/memory/cond	0.96725142
65	MP0002067_abnormal_sensory_capabilities	0.96199441
66	MP0001502_abnormal_circadian_rhythm	0.95026775
67	MP0003635_abnormal_synaptic_transmissio	0.94017740
68	MP0001970_abnormal_pain_threshold	0.92402035
69	MP0002249_abnormal_larynx_morphology	0.92111239
70	MP0005174_abnormal_tail_pigmentation	0.92079829
71	MP0008775_abnormal_heart_ventricle	0.91359719
72	MP0002234_abnormal_pharynx_morphology	0.91343166
73	MP0008875_abnormal_xenobiotic_pharmacok	0.91008949
74	MP0008872_abnormal_physiological_respon	0.89916692
75	MP0000569_abnormal_digit_pigmentation	0.89470888
76	MP0002210_abnormal_sex_determination	0.88689835
77	MP0001963_abnormal_hearing_physiology	0.87981008
78	MP0003890_abnormal_embryonic-extraembry	0.87166785
79	MP0005389_reproductive_system_phenotype	0.85660817
80	MP0005084_abnormal_gallbladder_morpholo	0.85198003
81	MP0003937_abnormal_limbs/digits/tail_de	0.83768855
82	MP0002064_seizures	0.83053317
83	MP0002882_abnormal_neuron_morphology	0.82289646
84	MP0001440_abnormal_grooming_behavior	0.82240981
85	MP0002733_abnormal_thermal_nociception	0.82024771
86	MP0002152_abnormal_brain_morphology	0.81763351
87	MP0002734_abnormal_mechanical_nocicepti	0.78259313
88	MP0003861_abnormal_nervous_system	0.77693941
89	MP0003942_abnormal_urinary_system	0.76648585
90	MP0003879_abnormal_hair_cell	0.75886243
91	MP0005391_vision/eye_phenotype	0.74796968
92	MP0001188_hyperpigmentation	0.71491172
93	MP0002092_abnormal_eye_morphology	0.69116937
94	MP0006072_abnormal_retinal_apoptosis	0.68817385
95	MP0002697_abnormal_eye_size	0.68433831
96	MP0002116_abnormal_craniofacial_bone	0.66589749
97	MP0003755_abnormal_palate_morphology	0.65363999
98	MP0004145_abnormal_muscle_electrophysio	0.65235232
99	MP0003936_abnormal_reproductive_system	0.64656727
100	MP0003315_abnormal_perineum_morphology	0.64226796

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.87074139
2	Abnormality of cells of the erythroid lineage (HP:0012130)	5.30075527
3	Macrocytic anemia (HP:0001972)	4.27527261
4	Molar tooth sign on MRI (HP:0002419)	3.98814371
5	Abnormality of midbrain morphology (HP:0002418)	3.98814371
6	Abnormal number of erythroid precursors (HP:0012131)	3.88764856
7	Acute necrotizing encephalopathy (HP:0006965)	3.73440901
8	Pancreatic fibrosis (HP:0100732)	3.69728178
9	Pallor (HP:0000980)	3.48800974
10	Acute encephalopathy (HP:0006846)	3.42264109
11	Septo-optic dysplasia (HP:0100842)	3.30498785
12	Abnormal mitochondria in muscle tissue (HP:0008316)	3.28580723
13	Medial flaring of the eyebrow (HP:0010747)	3.05011709
14	Pancreatic cysts (HP:0001737)	2.97321019
15	Rib fusion (HP:0000902)	2.96382295
16	Progressive macrocephaly (HP:0004481)	2.92859376
17	Mitochondrial inheritance (HP:0001427)	2.90727632
18	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.86767505
19	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.85814722
20	Nephronophthisis (HP:0000090)	2.85276876
21	Hyperglycinemia (HP:0002154)	2.81970762
22	Absent thumb (HP:0009777)	2.75256782
23	True hermaphroditism (HP:0010459)	2.70072548
24	Gait imbalance (HP:0002141)	2.60789229
25	Abnormality of the labia minora (HP:0012880)	2.60023580
26	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.58276631
27	Absent/shortened dynein arms (HP:0200106)	2.58276631
28	Increased CSF lactate (HP:0002490)	2.57175293
29	Congenital primary aphakia (HP:0007707)	2.54358107
30	Pendular nystagmus (HP:0012043)	2.54247977
31	Myokymia (HP:0002411)	2.53794136
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.52996581
33	Sclerocornea (HP:0000647)	2.52748666
34	Type II lissencephaly (HP:0007260)	2.48888187
35	Cerebral edema (HP:0002181)	2.48600887
36	Abnormality of DNA repair (HP:0003254)	2.48295184
37	Stenosis of the external auditory canal (HP:0000402)	2.44854883
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.40395115
39	Abnormality of the renal medulla (HP:0100957)	2.38298569
40	Anencephaly (HP:0002323)	2.38075284
41	Congenital stationary night blindness (HP:0007642)	2.36554484
42	Depressed nasal ridge (HP:0000457)	2.33807903
43	Asplenia (HP:0001746)	2.33666109
44	Nephrogenic diabetes insipidus (HP:0009806)	2.31597592
45	Abnormal hemoglobin (HP:0011902)	2.27101601
46	Abnormal ciliary motility (HP:0012262)	2.25464971
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.24336918
48	Abnormal respiratory epithelium morphology (HP:0012253)	2.24336918
49	Anophthalmia (HP:0000528)	2.22335116
50	Hypoplasia of the radius (HP:0002984)	2.21491213
51	Maternal diabetes (HP:0009800)	2.19277705
52	Postaxial foot polydactyly (HP:0001830)	2.19204815
53	Optic disc pallor (HP:0000543)	2.16028281
54	Agitation (HP:0000713)	2.15073814
55	Ectopic kidney (HP:0000086)	2.14044828
56	Tubular atrophy (HP:0000092)	2.12019297
57	Abnormality of the renal cortex (HP:0011035)	2.10509867
58	Adrenal hypoplasia (HP:0000835)	2.10001329
59	Abnormality of reticulocytes (HP:0004312)	2.09797426
60	Colon cancer (HP:0003003)	2.09215083
61	Decreased central vision (HP:0007663)	2.07022278
62	Optic nerve hypoplasia (HP:0000609)	2.06624297
63	Hepatocellular necrosis (HP:0001404)	2.05900934
64	Cystic liver disease (HP:0006706)	2.05653242
65	Vaginal atresia (HP:0000148)	2.03522885
66	Increased hepatocellular lipid droplets (HP:0006565)	2.03133468
67	Hyperthyroidism (HP:0000836)	2.03041045
68	Growth hormone deficiency (HP:0000824)	2.02415729
69	Poor coordination (HP:0002370)	2.02074007
70	Lipid accumulation in hepatocytes (HP:0006561)	1.99799742
71	Chronic hepatic failure (HP:0100626)	1.98709685
72	Abnormal respiratory motile cilium physiology (HP:0012261)	1.97834948
73	Genital tract atresia (HP:0001827)	1.97330225
74	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.96133593
75	Abolished electroretinogram (ERG) (HP:0000550)	1.95122149
76	Oligodactyly (HP:0012165)	1.89177174
77	Absent septum pellucidum (HP:0001331)	1.88909710
78	Forearm undergrowth (HP:0009821)	1.86521333
79	3-Methylglutaconic aciduria (HP:0003535)	1.85981775
80	Triphalangeal thumb (HP:0001199)	1.85484741
81	Partial duplication of thumb phalanx (HP:0009944)	1.85473149
82	Hypoplasia of the ulna (HP:0003022)	1.84953129
83	Oligodactyly (hands) (HP:0001180)	1.84202436
84	Hepatic necrosis (HP:0002605)	1.83855511
85	Optic nerve coloboma (HP:0000588)	1.82528623
86	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.82261531
87	Abnormality of the aortic arch (HP:0012303)	1.81381007
88	Postaxial hand polydactyly (HP:0001162)	1.80008382
89	Confusion (HP:0001289)	1.79278778
90	Holoprosencephaly (HP:0001360)	1.78852714
91	Polyphagia (HP:0002591)	1.78115992
92	Hyperglycinuria (HP:0003108)	1.78062500
93	Congenital hepatic fibrosis (HP:0002612)	1.77247466
94	Cerebellar dysplasia (HP:0007033)	1.76817176
95	Preaxial hand polydactyly (HP:0001177)	1.75910565
96	Renal dysplasia (HP:0000110)	1.75367441
97	Increased serum lactate (HP:0002151)	1.73181849
98	Supernumerary spleens (HP:0009799)	1.72865089
99	Horseshoe kidney (HP:0000085)	1.72751745
100	11 pairs of ribs (HP:0000878)	1.71806507

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	WNK4	3.55842176
2	DYRK2	3.11472142
3	MAP3K11	2.84889308
4	EPHB2	2.34881030
5	PINK1	2.26640394
6	WNK3	2.21250013
7	CASK	2.15056703
8	CDK19	2.09058277
9	LRRK2	2.08118127
10	TIE1	2.06526107
11	TYRO3	2.05974783
12	ADRBK2	2.01554689
13	TXK	1.95074964
14	ICK	1.93489502
15	BCKDK	1.93451002
16	GRK1	1.82527435
17	PIK3CA	1.81383445
18	CDC7	1.75989131
19	NUAK1	1.74098913
20	FRK	1.63978440
21	TNIK	1.60555884
22	EPHA4	1.57663786
23	STK39	1.56987736
24	PAK3	1.52834152
25	STK16	1.45762734
26	CAMK1	1.44974900
27	CAMKK2	1.44646422
28	CAMK1G	1.37540676
29	ZAK	1.33944097
30	NME2	1.28707969
31	NTRK2	1.26571328
32	CAMK1D	1.26145984
33	BMPR1B	1.23520491
34	MAP3K9	1.14796943
35	PNCK	1.10986488
36	MAP4K2	1.06814398
37	DMPK	1.06778192
38	PRKCG	0.97536176
39	NME1	0.95069754
40	STK11	0.90544176
41	MAP3K12	0.88966332
42	WNK1	0.88636503
43	DYRK3	0.87888111
44	CAMKK1	0.86236051
45	INSRR	0.86208256
46	ADRBK1	0.82762776
47	MKNK2	0.82285347
48	TLK1	0.80839793
49	BRAF	0.77672630
50	MAP2K7	0.76729673
51	NEK2	0.76721817
52	PRKCH	0.76280553
53	PRKCZ	0.73690013
54	CSNK2A2	0.73256155
55	CSNK1E	0.69715984
56	DYRK1B	0.69417811
57	AURKB	0.68482412
58	PRKACA	0.68155693
59	RPS6KA6	0.67728775
60	DAPK3	0.67646240
61	IKBKB	0.67211743
62	PAK6	0.65710103
63	MARK1	0.65568023
64	MAP3K4	0.64614612
65	MINK1	0.64269607
66	PRKCQ	0.63363100
67	PLK1	0.61006044
68	PRKCI	0.60343443
69	ARAF	0.59851316
70	PLK4	0.58973768
71	SGK223	0.58597625
72	SGK494	0.58597625
73	MAPK15	0.58075044
74	CSNK1G2	0.57011995
75	LIMK1	0.56913873
76	SIK2	0.56163560
77	PIM2	0.54287958
78	AURKA	0.53859378
79	PDK2	0.53347441
80	OXSR1	0.53057786
81	SGK1	0.52927211
82	MAP2K4	0.50555535
83	CSNK1A1	0.50273020
84	TNK2	0.49700692
85	RPS6KA5	0.49258881
86	CAMK4	0.49007203
87	ABL2	0.48826106
88	NTRK3	0.48672766
89	DYRK1A	0.48378842
90	AKT1	0.44536177
91	MAP4K1	0.42701176
92	RPS6KC1	0.42314205
93	RPS6KL1	0.42314205
94	BTK	0.42265497
95	KSR1	0.40725067
96	MAPK13	0.40719420
97	PRKCA	0.38777012
98	GRK7	0.38702706
99	PHKG2	0.38462752
100	PHKG1	0.38462752

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.61871424
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.07105214
3	Parkinsons disease_Homo sapiens_hsa05012	3.42134908
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.71773698
5	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.59830590
6	Huntingtons disease_Homo sapiens_hsa05016	2.45154695
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.43939755
8	Sulfur relay system_Homo sapiens_hsa04122	2.31175578
9	RNA polymerase_Homo sapiens_hsa03020	2.28809481
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.28285184
11	Alzheimers disease_Homo sapiens_hsa05010	2.20137101
12	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.14799727
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.82256616
14	Basal transcription factors_Homo sapiens_hsa03022	1.57958757
15	Phototransduction_Homo sapiens_hsa04744	1.52831762
16	RNA degradation_Homo sapiens_hsa03018	1.51170353
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.39206923
18	Protein export_Homo sapiens_hsa03060	1.38219672
19	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.29270362
20	Basal cell carcinoma_Homo sapiens_hsa05217	1.28491159
21	Caffeine metabolism_Homo sapiens_hsa00232	1.28064918
22	Homologous recombination_Homo sapiens_hsa03440	1.27058915
23	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.26987283
24	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.24421123
25	Fanconi anemia pathway_Homo sapiens_hsa03460	1.23801487
26	Nicotine addiction_Homo sapiens_hsa05033	1.19984410
27	One carbon pool by folate_Homo sapiens_hsa00670	1.18613717
28	Nucleotide excision repair_Homo sapiens_hsa03420	1.11290692
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.10151963
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.06809910
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.05386152
32	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05212079
33	Ether lipid metabolism_Homo sapiens_hsa00565	1.04547611
34	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.00010516
35	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.98536738
36	Mismatch repair_Homo sapiens_hsa03430	0.97907047
37	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.93452547
38	Fat digestion and absorption_Homo sapiens_hsa04975	0.93140556
39	Proteasome_Homo sapiens_hsa03050	0.92346966
40	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89730724
41	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.88922914
42	Nitrogen metabolism_Homo sapiens_hsa00910	0.88374145
43	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85057821
44	Peroxisome_Homo sapiens_hsa04146	0.84069151
45	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.77596731
46	Collecting duct acid secretion_Homo sapiens_hsa04966	0.77409221
47	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74394816
48	Tryptophan metabolism_Homo sapiens_hsa00380	0.74251976
49	Metabolic pathways_Homo sapiens_hsa01100	0.73931778
50	RNA transport_Homo sapiens_hsa03013	0.73123409
51	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.70842827
52	Insulin secretion_Homo sapiens_hsa04911	0.68419629
53	Asthma_Homo sapiens_hsa05310	0.68161785
54	Purine metabolism_Homo sapiens_hsa00230	0.68150808
55	Propanoate metabolism_Homo sapiens_hsa00640	0.64954676
56	Olfactory transduction_Homo sapiens_hsa04740	0.62831432
57	Notch signaling pathway_Homo sapiens_hsa04330	0.62398864
58	Glutamatergic synapse_Homo sapiens_hsa04724	0.62029863
59	Chemical carcinogenesis_Homo sapiens_hsa05204	0.61449390
60	Morphine addiction_Homo sapiens_hsa05032	0.60413644
61	Axon guidance_Homo sapiens_hsa04360	0.59137012
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.57287183
63	Spliceosome_Homo sapiens_hsa03040	0.56736773
64	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.56151819
65	Butanoate metabolism_Homo sapiens_hsa00650	0.56051546
66	Retinol metabolism_Homo sapiens_hsa00830	0.55877788
67	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.53372837
68	Base excision repair_Homo sapiens_hsa03410	0.50622373
69	Arginine and proline metabolism_Homo sapiens_hsa00330	0.49515332
70	DNA replication_Homo sapiens_hsa03030	0.49349875
71	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.48882341
72	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48623600
73	Steroid biosynthesis_Homo sapiens_hsa00100	0.47858917
74	Hippo signaling pathway_Homo sapiens_hsa04390	0.47346443
75	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.46614118
76	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45900504
77	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.45772829
78	Regulation of autophagy_Homo sapiens_hsa04140	0.45755428
79	Serotonergic synapse_Homo sapiens_hsa04726	0.44259908
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.43793260
81	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.42120309
82	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.41286533
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.40299069
84	Folate biosynthesis_Homo sapiens_hsa00790	0.39052501
85	Taste transduction_Homo sapiens_hsa04742	0.38840756
86	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38211047
87	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.37707766
88	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.36554875
89	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.28956314
90	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.28531789
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.27908887
92	Mineral absorption_Homo sapiens_hsa04978	0.25816985
93	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24669038
94	Primary immunodeficiency_Homo sapiens_hsa05340	0.23839403
95	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.23763046
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.23546210
97	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.22407948
98	Wnt signaling pathway_Homo sapiens_hsa04310	0.22325215
99	GABAergic synapse_Homo sapiens_hsa04727	0.22281820
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.21904759

RPL7AP73

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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