ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	viral transcription (GO:0019083)	9.10669789
2	translational termination (GO:0006415)	8.77181184
3	ribosomal small subunit assembly (GO:0000028)	8.41259961
4	ribosomal small subunit biogenesis (GO:0042274)	7.67289042
5	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	7.56579788
6	cotranslational protein targeting to membrane (GO:0006613)	7.48801036
7	protein targeting to ER (GO:0045047)	7.39959881
8	translational elongation (GO:0006414)	7.39805912
9	maturation of SSU-rRNA (GO:0030490)	7.12970795
10	establishment of protein localization to endoplasmic reticulum (GO:0072599)	7.06819483
11	protein localization to endoplasmic reticulum (GO:0070972)	6.92086597
12	cellular protein complex disassembly (GO:0043624)	6.78859733
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.53286195
14	ATP synthesis coupled proton transport (GO:0015986)	6.53286195
15	viral life cycle (GO:0019058)	6.52677645
16	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.52359777
17	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	6.43821569
18	translational initiation (GO:0006413)	5.91855770
19	establishment of protein localization to mitochondrial membrane (GO:0090151)	5.86701215
20	protein complex disassembly (GO:0043241)	5.75357447
21	chaperone-mediated protein transport (GO:0072321)	5.63323428
22	macromolecular complex disassembly (GO:0032984)	5.42768247
23	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.10333861
24	protein targeting to membrane (GO:0006612)	4.92414695
25	ribosomal large subunit biogenesis (GO:0042273)	4.90489669
26	respiratory electron transport chain (GO:0022904)	4.84938454
27	electron transport chain (GO:0022900)	4.79803312
28	translation (GO:0006412)	4.71110810
29	nuclear-transcribed mRNA catabolic process (GO:0000956)	4.58584530
30	protein complex biogenesis (GO:0070271)	4.48270278
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.43049395
32	NADH dehydrogenase complex assembly (GO:0010257)	4.43049395
33	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.43049395
34	mitochondrial respiratory chain complex assembly (GO:0033108)	4.32677909
35	mRNA catabolic process (GO:0006402)	4.32257020
36	DNA deamination (GO:0045006)	4.25993603
37	protein neddylation (GO:0045116)	4.04774842
38	RNA catabolic process (GO:0006401)	3.88694281
39	ribonucleoprotein complex biogenesis (GO:0022613)	3.87368432
40	GTP biosynthetic process (GO:0006183)	3.85812737
41	cellular component biogenesis (GO:0044085)	3.83084680
42	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.74971833
43	ATP biosynthetic process (GO:0006754)	3.71548390
44	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.70019403
45	behavioral response to nicotine (GO:0035095)	3.63570391
46	inner mitochondrial membrane organization (GO:0007007)	3.60706260
47	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.48997395
48	hydrogen ion transmembrane transport (GO:1902600)	3.46123758
49	sequestering of actin monomers (GO:0042989)	3.34841484
50	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.34716768
51	termination of RNA polymerase III transcription (GO:0006386)	3.34716768
52	UTP biosynthetic process (GO:0006228)	3.30800657
53	establishment of protein localization to membrane (GO:0090150)	3.29619872
54	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.29232758
55	ribonucleoside triphosphate biosynthetic process (GO:0009201)	3.26501661
56	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.26150423
57	intracellular protein transmembrane import (GO:0044743)	3.24135647
58	protein targeting (GO:0006605)	3.20452922
59	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.20351237
60	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.20351237
61	proton transport (GO:0015992)	3.11020550
62	hydrogen transport (GO:0006818)	3.04784610
63	establishment of protein localization to organelle (GO:0072594)	3.01660808
64	rRNA processing (GO:0006364)	2.97968430
65	rRNA modification (GO:0000154)	2.97895883
66	UTP metabolic process (GO:0046051)	2.97511473
67	rRNA metabolic process (GO:0016072)	2.94165040
68	cytidine deamination (GO:0009972)	2.88338968
69	cytidine metabolic process (GO:0046087)	2.88338968
70	cytidine catabolic process (GO:0006216)	2.88338968
71	protein targeting to mitochondrion (GO:0006626)	2.88180445
72	nucleoside triphosphate biosynthetic process (GO:0009142)	2.87580026
73	establishment of protein localization to mitochondrion (GO:0072655)	2.81073218
74	protein-cofactor linkage (GO:0018065)	2.76507971
75	guanosine-containing compound biosynthetic process (GO:1901070)	2.75762455
76	water-soluble vitamin biosynthetic process (GO:0042364)	2.74801095
77	proteasome assembly (GO:0043248)	2.71339529
78	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68556901
79	protein localization to mitochondrion (GO:0070585)	2.66750902
80	protein localization to membrane (GO:0072657)	2.66461482
81	CTP biosynthetic process (GO:0006241)	2.64388148
82	CTP metabolic process (GO:0046036)	2.64388148
83	DNA damage response, detection of DNA damage (GO:0042769)	2.63867782
84	pseudouridine synthesis (GO:0001522)	2.60928045
85	chromatin remodeling at centromere (GO:0031055)	2.60495538
86	pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)	2.58274961
87	regulation of mitochondrial translation (GO:0070129)	2.56789736
88	respiratory chain complex IV assembly (GO:0008535)	2.53582590
89	pyrimidine nucleoside triphosphate metabolic process (GO:0009147)	2.53174828
90	oxidative phosphorylation (GO:0006119)	2.52658010
91	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.50428735
92	negative regulation by host of viral transcription (GO:0043922)	2.48975325
93	tRNA processing (GO:0008033)	2.48404494
94	cytochrome complex assembly (GO:0017004)	2.48340299
95	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.45878062
96	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.44546591
97	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.44546591
98	mitochondrial transport (GO:0006839)	2.40595968
99	neuron fate determination (GO:0048664)	2.40393918
100	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.39416977

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.61872669
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.32648781
3	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.25705078
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.09430552
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.78951521
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.47402793
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.15488309
8	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.84581735
9	VDR_22108803_ChIP-Seq_LS180_Human	2.81780769
10	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.81522442
11	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.70260152
12	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.69789479
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.57930959
14	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.35537554
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.23590197
16	VDR_23849224_ChIP-Seq_CD4+_Human	2.21085626
17	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.10471087
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09022975
19	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.05628025
20	TTF2_22483619_ChIP-Seq_HELA_Human	2.04083176
21	ZNF274_21170338_ChIP-Seq_K562_Hela	2.02849164
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95079662
23	MYC_18940864_ChIP-ChIP_HL60_Human	1.93064139
24	FOXP3_21729870_ChIP-Seq_TREG_Human	1.91150102
25	XRN2_22483619_ChIP-Seq_HELA_Human	1.79738239
26	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.78950727
27	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.73817330
28	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.69153881
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.64654988
30	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.61862481
31	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.60985924
32	FUS_26573619_Chip-Seq_HEK293_Human	1.58139172
33	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.57505569
34	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.55125537
35	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.55086790
36	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.52822169
37	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.52569454
38	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.50820058
39	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.50378053
40	EWS_26573619_Chip-Seq_HEK293_Human	1.46951830
41	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.46418011
42	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.45327542
43	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45223691
44	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.40729297
45	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.35253948
46	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30667051
47	IRF1_19129219_ChIP-ChIP_H3396_Human	1.30406855
48	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.30122812
49	TP53_22573176_ChIP-Seq_HFKS_Human	1.29270375
50	IGF1R_20145208_ChIP-Seq_DFB_Human	1.27843768
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.25216666
52	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.23792872
53	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.22955843
54	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.21954649
55	SOX2_18555785_ChIP-Seq_MESCs_Mouse	1.20509562
56	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18078835
57	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.17282985
58	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.15706851
59	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.14856003
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.14053278
61	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10785513
62	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.10559602
63	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.09245379
64	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.07612761
65	GABP_19822575_ChIP-Seq_HepG2_Human	1.06339071
66	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.05577325
67	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.05551718
68	AR_20517297_ChIP-Seq_VCAP_Human	1.05217726
69	NANOG_20526341_ChIP-Seq_ESCs_Human	1.02931306
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02779134
71	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.00967838
72	TAF2_19829295_ChIP-Seq_ESCs_Human	0.98425003
73	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.97489925
74	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.96369062
75	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.96241738
76	NCOR_22424771_ChIP-Seq_293T_Human	0.95957605
77	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95877273
78	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95629677
79	DCP1A_22483619_ChIP-Seq_HELA_Human	0.95628820
80	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	0.95238592
81	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.94810308
82	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.94781403
83	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.92761753
84	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91970613
85	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	0.90996450
86	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.90808460
87	MYC_19829295_ChIP-Seq_ESCs_Human	0.90709708
88	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.89866718
89	SOX2_19829295_ChIP-Seq_ESCs_Human	0.89584338
90	NANOG_19829295_ChIP-Seq_ESCs_Human	0.89584338
91	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.88621176
92	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.88621176
93	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.87812629
94	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.84063393
95	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.83116324
96	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.82981589
97	CTCF_18555785_ChIP-Seq_MESCs_Mouse	0.82747188
98	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	0.82063286
99	P300_19829295_ChIP-Seq_ESCs_Human	0.80376677
100	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.80304713

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	7.07435687
2	MP0006292_abnormal_olfactory_placode	3.46357136
3	MP0003136_yellow_coat_color	2.25523121
4	MP0002638_abnormal_pupillary_reflex	2.11779338
5	MP0003880_abnormal_central_pattern	2.09223976
6	MP0003011_delayed_dark_adaptation	2.05962541
7	MP0005646_abnormal_pituitary_gland	2.03507428
8	MP0001293_anophthalmia	2.02695624
9	MP0002837_dystrophic_cardiac_calcinosis	2.00278303
10	MP0002234_abnormal_pharynx_morphology	1.98179019
11	MP0006072_abnormal_retinal_apoptosis	1.97104441
12	MP0002102_abnormal_ear_morphology	1.94019266
13	MP0005084_abnormal_gallbladder_morpholo	1.90526723
14	MP0004142_abnormal_muscle_tone	1.88244854
15	MP0001485_abnormal_pinna_reflex	1.85618613
16	MP0002163_abnormal_gland_morphology	1.82564097
17	MP0002938_white_spotting	1.82127613
18	MP0001529_abnormal_vocalization	1.77972743
19	MP0006276_abnormal_autonomic_nervous	1.76068469
20	MP0002653_abnormal_ependyma_morphology	1.75183711
21	MP0002277_abnormal_respiratory_mucosa	1.74390232
22	MP0000049_abnormal_middle_ear	1.73029663
23	MP0008877_abnormal_DNA_methylation	1.68938711
24	MP0001986_abnormal_taste_sensitivity	1.67780003
25	MP0008789_abnormal_olfactory_epithelium	1.59221512
26	MP0002736_abnormal_nociception_after	1.58368728
27	MP0005671_abnormal_response_to	1.55826407
28	MP0001968_abnormal_touch/_nociception	1.53211689
29	MP0010030_abnormal_orbit_morphology	1.49874984
30	MP0001905_abnormal_dopamine_level	1.48520889
31	MP0002160_abnormal_reproductive_system	1.40486169
32	MP0005551_abnormal_eye_electrophysiolog	1.40332875
33	MP0004147_increased_porphyrin_level	1.38741185
34	MP0004742_abnormal_vestibular_system	1.38731117
35	MP0005379_endocrine/exocrine_gland_phen	1.38626344
36	MP0003122_maternal_imprinting	1.38207520
37	MP0000372_irregular_coat_pigmentation	1.38122344
38	MP0003693_abnormal_embryo_hatching	1.32773367
39	MP0000631_abnormal_neuroendocrine_gland	1.31619069
40	MP0000778_abnormal_nervous_system	1.30828591
41	MP0003878_abnormal_ear_physiology	1.26814485
42	MP0005377_hearing/vestibular/ear_phenot	1.26814485
43	MP0005253_abnormal_eye_physiology	1.26608478
44	MP0005389_reproductive_system_phenotype	1.24328408
45	MP0005645_abnormal_hypothalamus_physiol	1.22953241
46	MP0008872_abnormal_physiological_respon	1.22744863
47	MP0002272_abnormal_nervous_system	1.21581725
48	MP0004133_heterotaxia	1.20795956
49	MP0004145_abnormal_muscle_electrophysio	1.16649669
50	MP0000026_abnormal_inner_ear	1.15639059
51	MP0003186_abnormal_redox_activity	1.12728148
52	MP0005075_abnormal_melanosome_morpholog	1.11579665
53	MP0005195_abnormal_posterior_eye	1.10253651
54	MP0005499_abnormal_olfactory_system	1.10170221
55	MP0005394_taste/olfaction_phenotype	1.10170221
56	MP0005423_abnormal_somatic_nervous	1.10086591
57	MP0009745_abnormal_behavioral_response	1.07261523
58	MP0003567_abnormal_fetal_cardiomyocyte	1.06045915
59	MP0004885_abnormal_endolymph	1.04369349
60	MP0005391_vision/eye_phenotype	1.01034871
61	MP0001286_abnormal_eye_development	1.00352815
62	MP0008875_abnormal_xenobiotic_pharmacok	0.99195418
63	MP0008058_abnormal_DNA_repair	0.99022878
64	MP0003315_abnormal_perineum_morphology	0.98689305
65	MP0003195_calcinosis	0.97309011
66	MP0002557_abnormal_social/conspecific_i	0.96792949
67	MP0003938_abnormal_ear_development	0.94956981
68	MP0002752_abnormal_somatic_nervous	0.94398275
69	MP0003646_muscle_fatigue	0.93116143
70	MP0001188_hyperpigmentation	0.92171810
71	MP0002095_abnormal_skin_pigmentation	0.91679265
72	MP0001502_abnormal_circadian_rhythm	0.90961180
73	MP0001919_abnormal_reproductive_system	0.89503837
74	MP0001963_abnormal_hearing_physiology	0.89155546
75	MP0002210_abnormal_sex_determination	0.87592071
76	MP0003937_abnormal_limbs/digits/tail_de	0.86651349
77	MP0001970_abnormal_pain_threshold	0.85877653
78	MP0002876_abnormal_thyroid_physiology	0.85624326
79	MP0003718_maternal_effect	0.85227953
80	MP0001486_abnormal_startle_reflex	0.85034708
81	MP0002733_abnormal_thermal_nociception	0.84500179
82	MP0002184_abnormal_innervation	0.84201978
83	MP0001984_abnormal_olfaction	0.84043883
84	MP0001440_abnormal_grooming_behavior	0.83706931
85	MP0000569_abnormal_digit_pigmentation	0.79152619
86	MP0002822_catalepsy	0.78503329
87	MP0008995_early_reproductive_senescence	0.78047298
88	MP0002735_abnormal_chemical_nociception	0.77124595
89	MP0000566_synostosis	0.76458946
90	MP0009046_muscle_twitch	0.76366018
91	MP0003119_abnormal_digestive_system	0.76196430
92	MP0006036_abnormal_mitochondrial_physio	0.75877479
93	MP0002064_seizures	0.75723546
94	MP0003786_premature_aging	0.71244446
95	MP0003283_abnormal_digestive_organ	0.69695728
96	MP0002572_abnormal_emotion/affect_behav	0.69537971
97	MP0003121_genomic_imprinting	0.67818641
98	MP0002928_abnormal_bile_duct	0.66597626
99	MP0001929_abnormal_gametogenesis	0.66592904
100	MP0002067_abnormal_sensory_capabilities	0.66254279

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Reticulocytopenia (HP:0001896)	6.36865398
2	Acute necrotizing encephalopathy (HP:0006965)	5.15095195
3	Abnormality of cells of the erythroid lineage (HP:0012130)	4.85569160
4	Abnormal mitochondria in muscle tissue (HP:0008316)	4.54589511
5	Mitochondrial inheritance (HP:0001427)	4.50581765
6	Abnormal number of erythroid precursors (HP:0012131)	4.47747057
7	Acute encephalopathy (HP:0006846)	4.27725886
8	Macrocytic anemia (HP:0001972)	4.26958993
9	Progressive macrocephaly (HP:0004481)	4.22655027
10	Increased hepatocellular lipid droplets (HP:0006565)	3.90206397
11	Increased CSF lactate (HP:0002490)	3.85071269
12	Hepatocellular necrosis (HP:0001404)	3.64209265
13	3-Methylglutaconic aciduria (HP:0003535)	3.47187987
14	Lipid accumulation in hepatocytes (HP:0006561)	3.40017203
15	Cerebral edema (HP:0002181)	3.27538359
16	Pallor (HP:0000980)	3.26834566
17	Hepatic necrosis (HP:0002605)	3.25310976
18	Pancreatic cysts (HP:0001737)	3.15614876
19	Renal Fanconi syndrome (HP:0001994)	3.10357193
20	Abnormality of midbrain morphology (HP:0002418)	2.96930025
21	Molar tooth sign on MRI (HP:0002419)	2.96930025
22	Pancreatic fibrosis (HP:0100732)	2.96156188
23	True hermaphroditism (HP:0010459)	2.92340937
24	Colon cancer (HP:0003003)	2.92101458
25	Absent thumb (HP:0009777)	2.91923726
26	Congenital, generalized hypertrichosis (HP:0004540)	2.85463178
27	Optic disc pallor (HP:0000543)	2.84022597
28	Increased intramyocellular lipid droplets (HP:0012240)	2.78433835
29	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.67162892
30	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.63501556
31	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.63501556
32	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.62416469
33	Exertional dyspnea (HP:0002875)	2.57304505
34	Septo-optic dysplasia (HP:0100842)	2.49851937
35	Sclerocornea (HP:0000647)	2.49217556
36	Medial flaring of the eyebrow (HP:0010747)	2.46423198
37	Aplastic anemia (HP:0001915)	2.41681895
38	Type II lissencephaly (HP:0007260)	2.38589773
39	Lactic acidosis (HP:0003128)	2.36952944
40	Leukodystrophy (HP:0002415)	2.35743125
41	Increased serum lactate (HP:0002151)	2.32399872
42	Triphalangeal thumb (HP:0001199)	2.29039736
43	Anophthalmia (HP:0000528)	2.28809058
44	Respiratory failure (HP:0002878)	2.28360055
45	Congenital stationary night blindness (HP:0007642)	2.26752791
46	Anencephaly (HP:0002323)	2.25294228
47	Nephronophthisis (HP:0000090)	2.24360374
48	Abnormality of renal resorption (HP:0011038)	2.18678006
49	Hyperglycinemia (HP:0002154)	2.18643738
50	Respiratory difficulties (HP:0002880)	2.18498808
51	Bilateral microphthalmos (HP:0007633)	2.18370259
52	Abnormality of the renal collecting system (HP:0004742)	2.15571135
53	Pendular nystagmus (HP:0012043)	2.14440803
54	Maternal diabetes (HP:0009800)	2.14394860
55	Increased muscle lipid content (HP:0009058)	2.14083539
56	Depressed nasal ridge (HP:0000457)	2.13625777
57	Exercise intolerance (HP:0003546)	2.11670206
58	Stenosis of the external auditory canal (HP:0000402)	2.02867351
59	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.01863013
60	Partial duplication of thumb phalanx (HP:0009944)	1.97651356
61	Lethargy (HP:0001254)	1.97557195
62	Duplicated collecting system (HP:0000081)	1.97502450
63	Gait imbalance (HP:0002141)	1.94411621
64	Congenital primary aphakia (HP:0007707)	1.90044549
65	Abnormality of the labia minora (HP:0012880)	1.89894384
66	Myokymia (HP:0002411)	1.88794887
67	Optic nerve hypoplasia (HP:0000609)	1.87438709
68	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87045439
69	Methylmalonic aciduria (HP:0012120)	1.85763111
70	Abnormal rod and cone electroretinograms (HP:0008323)	1.85688552
71	Abnormal respiratory motile cilium morphology (HP:0005938)	1.85410253
72	Abnormal respiratory epithelium morphology (HP:0012253)	1.85410253
73	Cerebellar dysplasia (HP:0007033)	1.85105466
74	Glycosuria (HP:0003076)	1.83659735
75	Abnormality of urine glucose concentration (HP:0011016)	1.83659735
76	Nephrogenic diabetes insipidus (HP:0009806)	1.83288454
77	Absent septum pellucidum (HP:0001331)	1.81843121
78	Pancytopenia (HP:0001876)	1.81525447
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81385323
80	Hypoplasia of the radius (HP:0002984)	1.81258981
81	Cystic liver disease (HP:0006706)	1.81160879
82	Constricted visual fields (HP:0001133)	1.81146917
83	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.80943123
84	Type 2 muscle fiber atrophy (HP:0003554)	1.79954883
85	Renal cortical cysts (HP:0000803)	1.79928162
86	Male pseudohermaphroditism (HP:0000037)	1.79404963
87	Abnormal ciliary motility (HP:0012262)	1.78954103
88	Abnormality of the renal medulla (HP:0100957)	1.77627187
89	Postaxial foot polydactyly (HP:0001830)	1.76601516
90	Concave nail (HP:0001598)	1.75864418
91	Supernumerary spleens (HP:0009799)	1.73526603
92	Methylmalonic acidemia (HP:0002912)	1.72817303
93	Horseshoe kidney (HP:0000085)	1.72712295
94	Aplasia/hypoplasia of the uterus (HP:0008684)	1.71802686
95	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.71675016
96	Absent/shortened dynein arms (HP:0200106)	1.71675016
97	Abnormality of the renal cortex (HP:0011035)	1.71515427
98	Partial duplication of the phalanx of hand (HP:0009999)	1.70887935
99	Meckel diverticulum (HP:0002245)	1.70579290
100	Chronic hepatic failure (HP:0100626)	1.70031408

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.33616268
2	TXK	3.10870261
3	VRK1	2.77671525
4	TLK1	2.51609023
5	NUAK1	2.43480796
6	ZAK	2.38855250
7	ADRBK2	2.35178191
8	TAF1	2.25478325
9	STK16	2.24296990
10	PASK	2.23452262
11	WNK4	2.15294735
12	NME1	2.13970244
13	TIE1	1.94992372
14	MAPK15	1.93421043
15	DYRK2	1.88042808
16	EPHB2	1.85395968
17	CDK19	1.84885677
18	GRK1	1.83136049
19	BCKDK	1.74359192
20	WNK3	1.74318972
21	PLK4	1.55231518
22	CDC7	1.40725837
23	KDR	1.40634897
24	MAP3K11	1.39483162
25	TAOK3	1.38112018
26	PNCK	1.36479253
27	NME2	1.29336736
28	BUB1	1.29301762
29	LRRK2	1.25600747
30	NEK1	1.23929069
31	FRK	1.22597431
32	WEE1	1.21484820
33	SRPK1	1.15967809
34	TSSK6	1.12615805
35	PINK1	1.10373747
36	PLK3	1.07839143
37	EPHA4	1.07543259
38	OXSR1	1.06776680
39	INSRR	1.05837819
40	MAP4K1	1.04475760
41	STK39	1.00239779
42	TNIK	1.00008564
43	TYRO3	0.99196354
44	BMPR1B	0.97548056
45	PDK2	0.95999683
46	TGFBR1	0.95778896
47	MAPK13	0.95312668
48	TEC	0.90780782
49	PRKCG	0.89332040
50	MAPKAPK5	0.88229816
51	MKNK1	0.84506844
52	DAPK2	0.80635802
53	NTRK2	0.79441296
54	FES	0.78963634
55	MAP4K2	0.78692285
56	ADRBK1	0.78303042
57	PRKCQ	0.78007017
58	RPS6KA5	0.75094728
59	GRK6	0.74770162
60	IKBKB	0.72371814
61	PIK3CA	0.72300660
62	AURKB	0.72291313
63	CSNK2A2	0.71967502
64	ITK	0.71773784
65	GRK7	0.70647854
66	PIM1	0.63128998
67	STK11	0.62836225
68	DAPK3	0.60037629
69	MAP3K4	0.58400355
70	CAMK1	0.57969184
71	GRK5	0.57950528
72	PRKACA	0.57698033
73	MKNK2	0.57362133
74	LIMK1	0.56823937
75	CSNK2A1	0.56590995
76	PHKG2	0.53669121
77	PHKG1	0.53669121
78	CCNB1	0.53255279
79	MAP3K12	0.51669566
80	PAK3	0.49172463
81	PLK1	0.48923169
82	NLK	0.48799458
83	MINK1	0.47931201
84	TESK2	0.46981333
85	EIF2AK1	0.46336918
86	OBSCN	0.45958520
87	AURKA	0.45818522
88	DYRK3	0.42459245
89	CAMKK2	0.42327528
90	CASK	0.41879506
91	IKBKE	0.38604576
92	KIT	0.38146073
93	MUSK	0.37674966
94	LCK	0.37085353
95	PLK2	0.36883634
96	MAP2K7	0.36711015
97	MAP2K2	0.36662940
98	TRIM28	0.34889392
99	SYK	0.34664876
100	PRKCD	0.34325134

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	7.12729171
2	Oxidative phosphorylation_Homo sapiens_hsa00190	4.92680593
3	Parkinsons disease_Homo sapiens_hsa05012	4.26348894
4	Proteasome_Homo sapiens_hsa03050	3.13370352
5	Huntingtons disease_Homo sapiens_hsa05016	2.91442825
6	RNA polymerase_Homo sapiens_hsa03020	2.86629556
7	Alzheimers disease_Homo sapiens_hsa05010	2.81418752
8	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.55932472
9	Cardiac muscle contraction_Homo sapiens_hsa04260	2.46011752
10	Protein export_Homo sapiens_hsa03060	2.12596508
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73133857
12	Homologous recombination_Homo sapiens_hsa03440	1.69392991
13	Primary immunodeficiency_Homo sapiens_hsa05340	1.54005437
14	Mismatch repair_Homo sapiens_hsa03430	1.53697381
15	RNA degradation_Homo sapiens_hsa03018	1.51888017
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.48888308
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.47888033
18	Spliceosome_Homo sapiens_hsa03040	1.38324593
19	Fanconi anemia pathway_Homo sapiens_hsa03460	1.36751320
20	Pyrimidine metabolism_Homo sapiens_hsa00240	1.36650068
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.35881156
22	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.34395890
23	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.31223498
24	Phototransduction_Homo sapiens_hsa04744	1.27798681
25	DNA replication_Homo sapiens_hsa03030	1.27767743
26	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.26198507
27	One carbon pool by folate_Homo sapiens_hsa00670	1.21056139
28	Purine metabolism_Homo sapiens_hsa00230	1.10544869
29	Folate biosynthesis_Homo sapiens_hsa00790	1.09923867
30	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.07212757
31	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99014607
32	Peroxisome_Homo sapiens_hsa04146	0.98947792
33	Sulfur relay system_Homo sapiens_hsa04122	0.98034024
34	Basal transcription factors_Homo sapiens_hsa03022	0.95409374
35	Propanoate metabolism_Homo sapiens_hsa00640	0.94376973
36	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90094663
37	Nucleotide excision repair_Homo sapiens_hsa03420	0.87756826
38	Asthma_Homo sapiens_hsa05310	0.87336568
39	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85046982
40	Nitrogen metabolism_Homo sapiens_hsa00910	0.82912106
41	RNA transport_Homo sapiens_hsa03013	0.81815964
42	Butanoate metabolism_Homo sapiens_hsa00650	0.80286378
43	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.77881930
44	Nicotine addiction_Homo sapiens_hsa05033	0.75407275
45	Metabolic pathways_Homo sapiens_hsa01100	0.72937778
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.72693701
47	Chemical carcinogenesis_Homo sapiens_hsa05204	0.72197791
48	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.69211535
49	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.67932400
50	Allograft rejection_Homo sapiens_hsa05330	0.66294088
51	Base excision repair_Homo sapiens_hsa03410	0.65259507
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63014187
53	Caffeine metabolism_Homo sapiens_hsa00232	0.61276295
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.61222688
55	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61083585
56	Sulfur metabolism_Homo sapiens_hsa00920	0.56621656
57	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.56505278
58	Retinol metabolism_Homo sapiens_hsa00830	0.56431339
59	Basal cell carcinoma_Homo sapiens_hsa05217	0.54321716
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.54182549
61	Type I diabetes mellitus_Homo sapiens_hsa04940	0.53312580
62	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.52966905
63	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52882127
64	Olfactory transduction_Homo sapiens_hsa04740	0.52548390
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51331649
66	Taste transduction_Homo sapiens_hsa04742	0.51131920
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.49898575
68	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.49637111
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.48477402
70	Pyruvate metabolism_Homo sapiens_hsa00620	0.47087806
71	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.46862232
72	Glutathione metabolism_Homo sapiens_hsa00480	0.44737077
73	Regulation of autophagy_Homo sapiens_hsa04140	0.43906175
74	Rheumatoid arthritis_Homo sapiens_hsa05323	0.43189156
75	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.42706012
76	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.41985446
77	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.41517273
78	Fatty acid elongation_Homo sapiens_hsa00062	0.41123955
79	Graft-versus-host disease_Homo sapiens_hsa05332	0.41010233
80	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40679358
81	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36680886
82	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.35356694
83	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.34949782
84	Morphine addiction_Homo sapiens_hsa05032	0.34590275
85	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.33660309
86	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.31556932
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.31330048
88	Steroid biosynthesis_Homo sapiens_hsa00100	0.30706092
89	Antigen processing and presentation_Homo sapiens_hsa04612	0.30374013
90	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.30121930
91	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.29082732
92	Serotonergic synapse_Homo sapiens_hsa04726	0.27948563
93	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.26238611
94	Arginine and proline metabolism_Homo sapiens_hsa00330	0.23269215
95	beta-Alanine metabolism_Homo sapiens_hsa00410	0.22605277
96	GABAergic synapse_Homo sapiens_hsa04727	0.21930118
97	Glycerolipid metabolism_Homo sapiens_hsa00561	0.21410024
98	Tyrosine metabolism_Homo sapiens_hsa00350	0.21074409
99	Insulin secretion_Homo sapiens_hsa04911	0.18317213
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.16493229

RPL7AP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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