ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of meiosis I (GO:0060631)	5.26699849
2	branched-chain amino acid catabolic process (GO:0009083)	4.74003594
3	heparin metabolic process (GO:0030202)	4.49330933
4	heparin biosynthetic process (GO:0030210)	4.49330933
5	L-fucose catabolic process (GO:0042355)	4.15699701
6	fucose catabolic process (GO:0019317)	4.15699701
7	L-fucose metabolic process (GO:0042354)	4.15699701
8	DNA deamination (GO:0045006)	3.95314659
9	branched-chain amino acid metabolic process (GO:0009081)	3.80608771
10	protein-cofactor linkage (GO:0018065)	3.74215198
11	C4-dicarboxylate transport (GO:0015740)	3.72361124
12	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.67025880
13	somatic diversification of immune receptors via somatic mutation (GO:0002566)	3.65475998
14	somatic hypermutation of immunoglobulin genes (GO:0016446)	3.65475998
15	DNA double-strand break processing (GO:0000729)	3.63234818
16	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.60761585
17	respiratory chain complex IV assembly (GO:0008535)	3.59448717
18	mismatch repair (GO:0006298)	3.57667962
19	histone H2A acetylation (GO:0043968)	3.57654801
20	replication fork processing (GO:0031297)	3.57531976
21	meiotic chromosome segregation (GO:0045132)	3.53879839
22	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	3.43749329
23	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	3.43749329
24	isotype switching (GO:0045190)	3.43749329
25	protein polyglutamylation (GO:0018095)	3.38733290
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.32565597
27	piRNA metabolic process (GO:0034587)	3.29479341
28	reciprocal meiotic recombination (GO:0007131)	3.28614649
29	reciprocal DNA recombination (GO:0035825)	3.28614649
30	regulation of glucokinase activity (GO:0033131)	3.25791188
31	regulation of hexokinase activity (GO:1903299)	3.25791188
32	cellular ketone body metabolic process (GO:0046950)	3.25454671
33	intraciliary transport (GO:0042073)	3.20328620
34	synapsis (GO:0007129)	3.19739213
35	C-terminal protein lipidation (GO:0006501)	3.18955468
36	indolalkylamine metabolic process (GO:0006586)	3.14238537
37	phenol-containing compound catabolic process (GO:0019336)	3.08601840
38	male meiosis I (GO:0007141)	3.07987023
39	protein neddylation (GO:0045116)	3.07636546
40	ubiquinone biosynthetic process (GO:0006744)	3.05375992
41	ubiquinone metabolic process (GO:0006743)	3.04177969
42	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.99769635
43	recombinational repair (GO:0000725)	2.99631938
44	double-strand break repair via homologous recombination (GO:0000724)	2.97871632
45	cytochrome complex assembly (GO:0017004)	2.97672793
46	response to nitrosative stress (GO:0051409)	2.94915312
47	tryptophan metabolic process (GO:0006568)	2.94346448
48	photoreceptor cell maintenance (GO:0045494)	2.92663651
49	C-terminal protein amino acid modification (GO:0018410)	2.92544868
50	peptidyl-histidine modification (GO:0018202)	2.90650307
51	pseudouridine synthesis (GO:0001522)	2.85884201
52	seminiferous tubule development (GO:0072520)	2.85375472
53	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.83525968
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.83079931
55	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.83079931
56	NADH dehydrogenase complex assembly (GO:0010257)	2.83079931
57	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.81871323
58	ketone body metabolic process (GO:1902224)	2.81717117
59	DNA-dependent DNA replication (GO:0006261)	2.79626966
60	somite development (GO:0061053)	2.78390119
61	protein K11-linked deubiquitination (GO:0035871)	2.77872683
62	magnesium ion transport (GO:0015693)	2.77769152
63	negative regulation of neurological system process (GO:0031645)	2.77569421
64	spermatid nucleus differentiation (GO:0007289)	2.77324487
65	water-soluble vitamin biosynthetic process (GO:0042364)	2.77171161
66	protein localization to cilium (GO:0061512)	2.77038293
67	aggressive behavior (GO:0002118)	2.73893832
68	platelet dense granule organization (GO:0060155)	2.72364690
69	microtubule severing (GO:0051013)	2.71221839
70	meiosis I (GO:0007127)	2.69761534
71	mitochondrial respiratory chain complex assembly (GO:0033108)	2.68701770
72	regulation of helicase activity (GO:0051095)	2.65955436
73	cullin deneddylation (GO:0010388)	2.65646656
74	DNA demethylation (GO:0080111)	2.65592754
75	somatic diversification of immunoglobulins (GO:0016445)	2.63340972
76	mannosylation (GO:0097502)	2.62618586
77	GPI anchor metabolic process (GO:0006505)	2.62038957
78	postreplication repair (GO:0006301)	2.61285406
79	cilium organization (GO:0044782)	2.61143599
80	indole-containing compound catabolic process (GO:0042436)	2.60867928
81	indolalkylamine catabolic process (GO:0046218)	2.60867928
82	tryptophan catabolic process (GO:0006569)	2.60867928
83	DNA methylation involved in gamete generation (GO:0043046)	2.60719447
84	cornea development in camera-type eye (GO:0061303)	2.60137679
85	cilium assembly (GO:0042384)	2.59762964
86	DNA damage response, detection of DNA damage (GO:0042769)	2.58550823
87	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.57415019
88	regulation of mitotic spindle checkpoint (GO:1903504)	2.57415019
89	purine nucleobase biosynthetic process (GO:0009113)	2.56907672
90	acrosome assembly (GO:0001675)	2.56839673
91	intra-S DNA damage checkpoint (GO:0031573)	2.55845006
92	behavioral response to nicotine (GO:0035095)	2.55532615
93	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.55087285
94	termination of RNA polymerase III transcription (GO:0006386)	2.55087285
95	isoprenoid biosynthetic process (GO:0008299)	2.54298189
96	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	2.53941991
97	protein complex biogenesis (GO:0070271)	2.53793801
98	cilium morphogenesis (GO:0060271)	2.53048624
99	axoneme assembly (GO:0035082)	2.51589102
100	neural tube formation (GO:0001841)	2.50304948

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.17384618
2	ZNF274_21170338_ChIP-Seq_K562_Hela	4.07758984
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.51904634
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.83788628
5	TAF15_26573619_Chip-Seq_HEK293_Human	2.80138077
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.74760555
7	FUS_26573619_Chip-Seq_HEK293_Human	2.67898394
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.67506477
9	GBX2_23144817_ChIP-Seq_PC3_Human	2.48636355
10	VDR_22108803_ChIP-Seq_LS180_Human	2.45623289
11	EWS_26573619_Chip-Seq_HEK293_Human	2.44411430
12	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.42509161
13	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.30047005
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.28716887
15	IGF1R_20145208_ChIP-Seq_DFB_Human	2.27048377
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.26374437
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.25367886
18	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.24099383
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.21151593
20	P300_19829295_ChIP-Seq_ESCs_Human	2.20079987
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11268006
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.95487559
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.94881657
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.80297201
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.73693351
26	VDR_23849224_ChIP-Seq_CD4+_Human	1.67706271
27	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.67026376
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65700691
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.58304868
30	CBP_20019798_ChIP-Seq_JUKART_Human	1.56018669
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.56018669
32	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.50975281
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.49569011
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47596707
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.46197316
36	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44387891
37	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.42067088
38	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40652459
39	SOX2_19829295_ChIP-Seq_ESCs_Human	1.39523685
40	NANOG_19829295_ChIP-Seq_ESCs_Human	1.39523685
41	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.39457670
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.39153196
43	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.38527132
44	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37994151
45	TCF4_23295773_ChIP-Seq_U87_Human	1.37458815
46	BCAT_22108803_ChIP-Seq_LS180_Human	1.36734794
47	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.35856959
48	MYC_18940864_ChIP-ChIP_HL60_Human	1.35331626
49	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.34852274
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.34279822
51	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.33844794
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.32377358
53	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.32287147
54	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31922230
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31922230
56	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.30516979
57	AR_25329375_ChIP-Seq_VCAP_Human	1.30294649
58	FOXP3_21729870_ChIP-Seq_TREG_Human	1.29165520
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29124471
60	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28857674
61	IRF1_19129219_ChIP-ChIP_H3396_Human	1.28716120
62	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28555109
63	AR_20517297_ChIP-Seq_VCAP_Human	1.27762131
64	TCF4_22108803_ChIP-Seq_LS180_Human	1.27029781
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.26568206
66	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.26081916
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22791691
68	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21155518
69	STAT3_23295773_ChIP-Seq_U87_Human	1.21073472
70	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.20031433
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16901401
72	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.15320832
73	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13940761
74	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.13805288
75	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.13044536
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.12534463
77	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.12506381
78	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.11669195
79	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.10752493
80	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.09866661
81	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09577367
82	HOXB7_26014856_ChIP-Seq_BT474_Human	1.09319097
83	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09302435
84	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07961043
85	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06073420
86	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.05677535
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04874102
88	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04775901
89	P53_22387025_ChIP-Seq_ESCs_Mouse	1.03919733
90	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.03613627
91	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.03224811
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02638545
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.02638545
94	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.01765191
95	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.01426981
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.99790086
97	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97132919
98	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.96459867
99	P300_18555785_Chip-Seq_ESCs_Mouse	0.95364268
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.94231045

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006072_abnormal_retinal_apoptosis	3.58359361
2	MP0008877_abnormal_DNA_methylation	3.38901641
3	MP0008058_abnormal_DNA_repair	3.26401554
4	MP0009697_abnormal_copulation	2.78594434
5	MP0002234_abnormal_pharynx_morphology	2.77227522
6	MP0005253_abnormal_eye_physiology	2.72564851
7	MP0000372_irregular_coat_pigmentation	2.71697507
8	MP0001986_abnormal_taste_sensitivity	2.62414630
9	MP0005084_abnormal_gallbladder_morpholo	2.14830744
10	MP0005645_abnormal_hypothalamus_physiol	2.14501798
11	MP0001764_abnormal_homeostasis	2.01153798
12	MP0002736_abnormal_nociception_after	2.00172112
13	MP0010094_abnormal_chromosome_stability	1.99643248
14	MP0005551_abnormal_eye_electrophysiolog	1.98306916
15	MP0001968_abnormal_touch/_nociception	1.96468301
16	MP0003787_abnormal_imprinting	1.96218601
17	MP0002102_abnormal_ear_morphology	1.93867392
18	MP0003195_calcinosis	1.90503224
19	MP0008872_abnormal_physiological_respon	1.88887081
20	MP0001984_abnormal_olfaction	1.88589494
21	MP0006292_abnormal_olfactory_placode	1.74813891
22	MP0002751_abnormal_autonomic_nervous	1.74600555
23	MP0000383_abnormal_hair_follicle	1.73262420
24	MP0001501_abnormal_sleep_pattern	1.69580983
25	MP0003567_abnormal_fetal_cardiomyocyte	1.63498541
26	MP0001529_abnormal_vocalization	1.63419685
27	MP0005367_renal/urinary_system_phenotyp	1.60942960
28	MP0000516_abnormal_urinary_system	1.60942960
29	MP0005646_abnormal_pituitary_gland	1.57830209
30	MP0002254_reproductive_system_inflammat	1.49529125
31	MP0000427_abnormal_hair_cycle	1.48267111
32	MP0002837_dystrophic_cardiac_calcinosis	1.46840189
33	MP0003868_abnormal_feces_composition	1.42144842
34	MP0003880_abnormal_central_pattern	1.41465791
35	MP0002272_abnormal_nervous_system	1.39761160
36	MP0002928_abnormal_bile_duct	1.39418408
37	MP0004215_abnormal_myocardial_fiber	1.37670346
38	MP0006276_abnormal_autonomic_nervous	1.35553617
39	MP0003011_delayed_dark_adaptation	1.33960737
40	MP0002938_white_spotting	1.33011635
41	MP0006054_spinal_hemorrhage	1.30727334
42	MP0001293_anophthalmia	1.30199424
43	MP0010678_abnormal_skin_adnexa	1.29740267
44	MP0008007_abnormal_cellular_replicative	1.25600015
45	MP0000613_abnormal_salivary_gland	1.24285519
46	MP0005391_vision/eye_phenotype	1.22634368
47	MP0003786_premature_aging	1.17739034
48	MP0003890_abnormal_embryonic-extraembry	1.17180825
49	MP0002653_abnormal_ependyma_morphology	1.15534192
50	MP0006036_abnormal_mitochondrial_physio	1.15325903
51	MP0003252_abnormal_bile_duct	1.15242271
52	MP0004142_abnormal_muscle_tone	1.13615759
53	MP0000569_abnormal_digit_pigmentation	1.12540932
54	MP0004043_abnormal_pH_regulation	1.11929620
55	MP0001929_abnormal_gametogenesis	1.11903576
56	MP0008057_abnormal_DNA_replication	1.10767243
57	MP0008875_abnormal_xenobiotic_pharmacok	1.04898401
58	MP0002876_abnormal_thyroid_physiology	1.04755456
59	MP0003119_abnormal_digestive_system	1.04576651
60	MP0003121_genomic_imprinting	1.04310353
61	MP0009745_abnormal_behavioral_response	1.03354233
62	MP0010386_abnormal_urinary_bladder	1.01019017
63	MP0005085_abnormal_gallbladder_physiolo	0.99898226
64	MP0001486_abnormal_startle_reflex	0.99295132
65	MP0000631_abnormal_neuroendocrine_gland	0.99093081
66	MP0009046_muscle_twitch	0.98044828
67	MP0002210_abnormal_sex_determination	0.95895577
68	MP0008775_abnormal_heart_ventricle	0.92977601
69	MP0004147_increased_porphyrin_level	0.91660635
70	MP0004885_abnormal_endolymph	0.91340837
71	MP0003698_abnormal_male_reproductive	0.91212834
72	MP0000653_abnormal_sex_gland	0.90642540
73	MP0001177_atelectasis	0.89149123
74	MP0004484_altered_response_of	0.88147309
75	MP0005220_abnormal_exocrine_pancreas	0.87547915
76	MP0008789_abnormal_olfactory_epithelium	0.86567597
77	MP0002572_abnormal_emotion/affect_behav	0.86376971
78	MP0006035_abnormal_mitochondrial_morpho	0.85343670
79	MP0003646_muscle_fatigue	0.85018078
80	MP0003937_abnormal_limbs/digits/tail_de	0.84891408
81	MP0005394_taste/olfaction_phenotype	0.84740876
82	MP0005499_abnormal_olfactory_system	0.84740876
83	MP0002557_abnormal_social/conspecific_i	0.84455575
84	MP0002090_abnormal_vision	0.84386664
85	MP0005195_abnormal_posterior_eye	0.83512615
86	MP0003943_abnormal_hepatobiliary_system	0.83457347
87	MP0001145_abnormal_male_reproductive	0.81397154
88	MP0002127_abnormal_cardiovascular_syste	0.81215256
89	MP0003137_abnormal_impulse_conducting	0.79789163
90	MP0003718_maternal_effect	0.79720539
91	MP0005310_abnormal_salivary_gland	0.79371032
92	MP0005410_abnormal_fertilization	0.78904680
93	MP0001666_abnormal_nutrient_absorption	0.77256454
94	MP0005174_abnormal_tail_pigmentation	0.76252633
95	MP0000538_abnormal_urinary_bladder	0.75868175
96	MP0009764_decreased_sensitivity_to	0.74673797
97	MP0005332_abnormal_amino_acid	0.73552940
98	MP0004133_heterotaxia	0.71753399
99	MP0002233_abnormal_nose_morphology	0.71494527
100	MP0001119_abnormal_female_reproductive	0.71444736

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Chronic hepatic failure (HP:0100626)	3.86832063
2	Pancreatic fibrosis (HP:0100732)	3.83300940
3	True hermaphroditism (HP:0010459)	3.42135819
4	Colon cancer (HP:0003003)	3.27153177
5	Pancreatic cysts (HP:0001737)	3.23732496
6	Ependymoma (HP:0002888)	3.22694991
7	Abnormality of B cell number (HP:0010975)	3.18961084
8	Thyroiditis (HP:0100646)	3.18711243
9	Abnormality of midbrain morphology (HP:0002418)	3.02517253
10	Molar tooth sign on MRI (HP:0002419)	3.02517253
11	B lymphocytopenia (HP:0010976)	2.96312670
12	Severe combined immunodeficiency (HP:0004430)	2.95582766
13	Medial flaring of the eyebrow (HP:0010747)	2.94465694
14	Intestinal atresia (HP:0011100)	2.86715344
15	Hypothermia (HP:0002045)	2.84518835
16	Panhypogammaglobulinemia (HP:0003139)	2.84226211
17	Methylmalonic acidemia (HP:0002912)	2.77885390
18	Abnormality of the renal cortex (HP:0011035)	2.71878091
19	Hypoproteinemia (HP:0003075)	2.71855710
20	Volvulus (HP:0002580)	2.70057586
21	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.66335106
22	Short tibia (HP:0005736)	2.65720765
23	Hyperglycinuria (HP:0003108)	2.64897385
24	Nephronophthisis (HP:0000090)	2.52091634
25	Bile duct proliferation (HP:0001408)	2.50472096
26	Abnormal biliary tract physiology (HP:0012439)	2.50472096
27	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.48092673
28	Renal cortical cysts (HP:0000803)	2.47273698
29	Glioma (HP:0009733)	2.45704722
30	Abolished electroretinogram (ERG) (HP:0000550)	2.44743039
31	Congenital primary aphakia (HP:0007707)	2.38771163
32	Nephrogenic diabetes insipidus (HP:0009806)	2.38678861
33	Postaxial foot polydactyly (HP:0001830)	2.38433843
34	Gait imbalance (HP:0002141)	2.37077939
35	Progressive inability to walk (HP:0002505)	2.29953892
36	Genital tract atresia (HP:0001827)	2.28304851
37	Abnormality of glycine metabolism (HP:0010895)	2.27959297
38	Abnormality of serine family amino acid metabolism (HP:0010894)	2.27959297
39	Abnormality of lateral ventricle (HP:0030047)	2.26214953
40	Methylmalonic aciduria (HP:0012120)	2.25115472
41	Abnormality of the renal medulla (HP:0100957)	2.24943400
42	Congenital hepatic fibrosis (HP:0002612)	2.21551967
43	Occipital encephalocele (HP:0002085)	2.21217523
44	Hyperglycinemia (HP:0002154)	2.19784946
45	Abnormality of the labia minora (HP:0012880)	2.17723697
46	Cerebellar dysplasia (HP:0007033)	2.17614459
47	Preaxial hand polydactyly (HP:0001177)	2.17553549
48	Combined immunodeficiency (HP:0005387)	2.17033440
49	Ketosis (HP:0001946)	2.15062122
50	Abnormality of macular pigmentation (HP:0008002)	2.14648055
51	Abnormality of the astrocytes (HP:0100707)	2.12822624
52	Astrocytoma (HP:0009592)	2.12822624
53	Congenital stationary night blindness (HP:0007642)	2.11849525
54	Medulloblastoma (HP:0002885)	2.10872808
55	Type II lissencephaly (HP:0007260)	2.05856104
56	Increased CSF lactate (HP:0002490)	2.02909831
57	Mitochondrial inheritance (HP:0001427)	2.02321239
58	Sclerocornea (HP:0000647)	1.99754630
59	Acute necrotizing encephalopathy (HP:0006965)	1.98767276
60	Cystic liver disease (HP:0006706)	1.97693956
61	Neoplasm of the adrenal cortex (HP:0100641)	1.96681489
62	Agnosia (HP:0010524)	1.95888623
63	Acute encephalopathy (HP:0006846)	1.95639659
64	Inability to walk (HP:0002540)	1.95557411
65	Hepatocellular necrosis (HP:0001404)	1.95016769
66	Anencephaly (HP:0002323)	1.94273004
67	Erythroderma (HP:0001019)	1.94053538
68	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.92523953
69	Pigmentary retinal degeneration (HP:0001146)	1.90843321
70	Lipid accumulation in hepatocytes (HP:0006561)	1.90659830
71	Vaginal atresia (HP:0000148)	1.88975127
72	Narrow forehead (HP:0000341)	1.88482486
73	Small hand (HP:0200055)	1.88011913
74	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.86136099
75	Abnormality of chromosome stability (HP:0003220)	1.85689354
76	Progressive macrocephaly (HP:0004481)	1.83940184
77	Postaxial hand polydactyly (HP:0001162)	1.83449220
78	Ketoacidosis (HP:0001993)	1.83063722
79	Sloping forehead (HP:0000340)	1.81981677
80	Polydipsia (HP:0001959)	1.81833582
81	Abnormal drinking behavior (HP:0030082)	1.81833582
82	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.80422953
83	Median cleft lip (HP:0000161)	1.79461741
84	Hepatic necrosis (HP:0002605)	1.79262607
85	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.74314220
86	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.74314220
87	Abnormality of vitamin B metabolism (HP:0004340)	1.73573257
88	Rhabdomyosarcoma (HP:0002859)	1.73331593
89	Pachygyria (HP:0001302)	1.73099751
90	Neoplasm of the adrenal gland (HP:0100631)	1.72970389
91	Multicystic kidney dysplasia (HP:0000003)	1.70344550
92	Lissencephaly (HP:0001339)	1.69660993
93	Impulsivity (HP:0100710)	1.69252061
94	Attenuation of retinal blood vessels (HP:0007843)	1.68333326
95	Type I transferrin isoform profile (HP:0003642)	1.64115046
96	Abnormal rod and cone electroretinograms (HP:0008323)	1.63931456
97	Stomach cancer (HP:0012126)	1.63211717
98	Abnormal hair whorl (HP:0010721)	1.62198127
99	Cerebral edema (HP:0002181)	1.61783878
100	Hemiparesis (HP:0001269)	1.61097761

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.77145711
2	EIF2AK3	3.45651047
3	MAP4K2	3.42860205
4	NUAK1	2.98979215
5	TRIM28	2.65857500
6	WNK3	2.65233841
7	MAPK13	2.62194837
8	PNCK	2.51999568
9	ZAK	2.22042606
10	VRK2	2.15985536
11	STK16	2.12166375
12	ADRBK2	1.74537067
13	TXK	1.67890678
14	PBK	1.66503410
15	BMPR1B	1.64055862
16	GRK1	1.62104248
17	STK39	1.61101572
18	CAMKK2	1.59762909
19	OXSR1	1.50278798
20	ERBB3	1.49385269
21	PINK1	1.43424394
22	TNIK	1.42648969
23	VRK1	1.40711422
24	MKNK1	1.33824860
25	WNK4	1.31680529
26	ACVR1B	1.30157396
27	BCKDK	1.27875359
28	MST4	1.27195680
29	TAF1	1.23261735
30	CSNK1G3	1.22579662
31	BRSK2	1.21133758
32	MKNK2	1.21032617
33	TIE1	1.20416048
34	PLK3	1.17995970
35	CSNK1G1	1.16069128
36	PLK2	1.14287156
37	PLK4	1.13537843
38	BCR	1.13071343
39	CSNK1G2	1.10996032
40	SRPK1	1.05180508
41	TAOK3	1.01341766
42	RPS6KA4	1.00098891
43	MAP3K4	0.98580983
44	EIF2AK1	0.97867139
45	CSNK1A1L	0.96297902
46	MAPKAPK5	0.95401620
47	KSR1	0.92842897
48	DAPK1	0.92660111
49	PKN1	0.91044810
50	CLK1	0.88200048
51	FLT3	0.86737601
52	INSRR	0.86128248
53	PRKCE	0.85550461
54	WEE1	0.85415840
55	PAK3	0.84797051
56	ATR	0.80064728
57	NTRK3	0.78840781
58	TSSK6	0.73465245
59	CDK3	0.73343595
60	DYRK3	0.73311342
61	TNK2	0.68575898
62	ERBB4	0.68504604
63	DYRK2	0.65073575
64	DAPK2	0.63617985
65	KIT	0.63563438
66	MAPKAPK3	0.63137093
67	CASK	0.63119130
68	PIK3CA	0.62979788
69	MAP3K12	0.61054033
70	TEC	0.58880712
71	RAF1	0.58628317
72	CAMK1G	0.58318645
73	NEK1	0.56386336
74	MAP2K7	0.55798678
75	PRKCG	0.55070049
76	MINK1	0.51500602
77	FGFR2	0.46545300
78	EIF2AK2	0.46359125
79	PRKCI	0.45731086
80	CSNK1A1	0.45102506
81	CAMK2A	0.44340533
82	PRKCQ	0.43353485
83	CAMK4	0.42955799
84	ATM	0.42482713
85	PLK1	0.37034311
86	CDK9	0.35790945
87	BUB1	0.34120729
88	ABL1	0.29197132
89	PRKD3	0.28862915
90	PRKG1	0.28763691
91	STK38L	0.28367827
92	IGF1R	0.28320316
93	MAP3K5	0.28034162
94	MAP2K6	0.27946894
95	IKBKB	0.26989108
96	MUSK	0.26937385
97	MARK1	0.26733834
98	PRKACB	0.25728384
99	CHEK2	0.25434514
100	PRKACA	0.25043617

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	4.03171125
2	Propanoate metabolism_Homo sapiens_hsa00640	3.08609132
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.84975805
4	Protein export_Homo sapiens_hsa03060	2.75170219
5	Butanoate metabolism_Homo sapiens_hsa00650	2.73317439
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.55824046
7	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.51522026
8	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.21303219
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.06210199
10	Non-homologous end-joining_Homo sapiens_hsa03450	2.04007549
11	Basal transcription factors_Homo sapiens_hsa03022	2.03724007
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.03282267
13	Caffeine metabolism_Homo sapiens_hsa00232	2.01779836
14	Proteasome_Homo sapiens_hsa03050	2.00617878
15	Mismatch repair_Homo sapiens_hsa03430	1.95698313
16	Homologous recombination_Homo sapiens_hsa03440	1.93722221
17	Linoleic acid metabolism_Homo sapiens_hsa00591	1.88763029
18	Fanconi anemia pathway_Homo sapiens_hsa03460	1.88614162
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.85169016
20	RNA polymerase_Homo sapiens_hsa03020	1.80953069
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.73140007
22	Fatty acid elongation_Homo sapiens_hsa00062	1.71046741
23	RNA degradation_Homo sapiens_hsa03018	1.65033196
24	Steroid biosynthesis_Homo sapiens_hsa00100	1.64886586
25	Regulation of autophagy_Homo sapiens_hsa04140	1.59052552
26	Fatty acid metabolism_Homo sapiens_hsa01212	1.54094694
27	Fatty acid degradation_Homo sapiens_hsa00071	1.45917857
28	Phototransduction_Homo sapiens_hsa04744	1.43021772
29	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.41125388
30	Peroxisome_Homo sapiens_hsa04146	1.38635010
31	Nucleotide excision repair_Homo sapiens_hsa03420	1.37955677
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.35659780
33	Selenocompound metabolism_Homo sapiens_hsa00450	1.31957779
34	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.30222240
35	Primary immunodeficiency_Homo sapiens_hsa05340	1.21708656
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.18529660
37	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.16919880
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.13947829
39	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13538540
40	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.12781476
41	Nicotine addiction_Homo sapiens_hsa05033	1.08423746
42	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.08263992
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.07338627
44	Olfactory transduction_Homo sapiens_hsa04740	1.04610280
45	Sulfur metabolism_Homo sapiens_hsa00920	1.04532909
46	Nitrogen metabolism_Homo sapiens_hsa00910	0.97327829
47	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.95621703
48	Pyruvate metabolism_Homo sapiens_hsa00620	0.93362363
49	One carbon pool by folate_Homo sapiens_hsa00670	0.88621864
50	Oxidative phosphorylation_Homo sapiens_hsa00190	0.87096792
51	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.86546107
52	Purine metabolism_Homo sapiens_hsa00230	0.86435858
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85970932
54	Fat digestion and absorption_Homo sapiens_hsa04975	0.79195540
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.78279712
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.77188235
57	Retinol metabolism_Homo sapiens_hsa00830	0.75416867
58	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75325291
59	Glutathione metabolism_Homo sapiens_hsa00480	0.74280563
60	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.73978967
61	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.73710663
62	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72787296
63	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70293168
64	Pyrimidine metabolism_Homo sapiens_hsa00240	0.70242258
65	Metabolic pathways_Homo sapiens_hsa01100	0.67972793
66	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.65365601
67	DNA replication_Homo sapiens_hsa03030	0.63822378
68	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.63580667
69	Parkinsons disease_Homo sapiens_hsa05012	0.61934923
70	RNA transport_Homo sapiens_hsa03013	0.61508751
71	Circadian entrainment_Homo sapiens_hsa04713	0.58077211
72	Serotonergic synapse_Homo sapiens_hsa04726	0.54918153
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.54058851
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.51869489
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.50540293
76	Amphetamine addiction_Homo sapiens_hsa05031	0.49708002
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.49250790
78	Glutamatergic synapse_Homo sapiens_hsa04724	0.48448384
79	Base excision repair_Homo sapiens_hsa03410	0.47693025
80	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.47209646
81	ABC transporters_Homo sapiens_hsa02010	0.46696912
82	Taste transduction_Homo sapiens_hsa04742	0.45262972
83	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.44966558
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44889421
85	Oocyte meiosis_Homo sapiens_hsa04114	0.44477751
86	Morphine addiction_Homo sapiens_hsa05032	0.43907477
87	Folate biosynthesis_Homo sapiens_hsa00790	0.43747060
88	Renin secretion_Homo sapiens_hsa04924	0.43346324
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42791713
90	Long-term depression_Homo sapiens_hsa04730	0.42628392
91	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.42588562
92	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.35953217
93	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.34171869
94	Circadian rhythm_Homo sapiens_hsa04710	0.33508113
95	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.33483321
96	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.33298007
97	Huntingtons disease_Homo sapiens_hsa05016	0.31709878
98	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30118496
99	Salivary secretion_Homo sapiens_hsa04970	0.29841552
100	Spliceosome_Homo sapiens_hsa03040	0.29388774

RPL7L1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »