RPL7L1P3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1snRNA metabolic process (GO:0016073)9.25223855
2protein K11-linked deubiquitination (GO:0035871)9.06203307
3peptidyl-threonine dephosphorylation (GO:0035970)8.07774971
4regulation of MHC class II biosynthetic process (GO:0045346)7.55249849
5mitochondrion degradation (GO:0000422)7.47848203
6UDP-N-acetylglucosamine metabolic process (GO:0006047)7.42411393
7histone H3-K4 trimethylation (GO:0080182)7.36248366
8rRNA catabolic process (GO:0016075)6.86652701
9interferon-gamma production (GO:0032609)5.91124377
10positive regulation of triglyceride biosynthetic process (GO:0010867)5.79891342
11N-acetylneuraminate metabolic process (GO:0006054)5.68019172
12vesicle targeting (GO:0006903)5.53786847
13negative regulation of fatty acid biosynthetic process (GO:0045717)5.21519482
14interleukin-6-mediated signaling pathway (GO:0070102)5.19435210
15reciprocal DNA recombination (GO:0035825)5.14947355
16reciprocal meiotic recombination (GO:0007131)5.14947355
17acrosome assembly (GO:0001675)5.10373159
18C-terminal protein lipidation (GO:0006501)5.08312179
19auditory receptor cell stereocilium organization (GO:0060088)4.99225986
20mismatch repair (GO:0006298)4.90578187
21carnitine metabolic process (GO:0009437)4.90096656
22fucose catabolic process (GO:0019317)4.87327163
23L-fucose metabolic process (GO:0042354)4.87327163
24L-fucose catabolic process (GO:0042355)4.87327163
25cellular response to exogenous dsRNA (GO:0071360)4.80805795
26negative regulation of type I interferon production (GO:0032480)4.63791085
27regulation of triglyceride biosynthetic process (GO:0010866)4.60630777
28phosphatidylinositol acyl-chain remodeling (GO:0036149)4.58987468
29inner ear receptor stereocilium organization (GO:0060122)4.54870663
30positive regulation of defense response to virus by host (GO:0002230)4.50105306
31interkinetic nuclear migration (GO:0022027)4.40638703
32positive regulation of histone H3-K4 methylation (GO:0051571)4.40265098
33C-terminal protein amino acid modification (GO:0018410)4.30209028
34positive regulation of cytokinesis (GO:0032467)4.28453745
35peptidyl-lysine trimethylation (GO:0018023)4.25813508
36kynurenine metabolic process (GO:0070189)4.18278211
37granulocyte differentiation (GO:0030851)4.17242903
38female gamete generation (GO:0007292)4.16559891
39phosphatidylserine acyl-chain remodeling (GO:0036150)4.04344380
40regulation of fatty acid oxidation (GO:0046320)4.01511268
41negative regulation of interleukin-8 production (GO:0032717)4.01116015
42negative regulation of NF-kappaB import into nucleus (GO:0042347)3.99901783
43indole-containing compound catabolic process (GO:0042436)3.95607264
44indolalkylamine catabolic process (GO:0046218)3.95607264
45tryptophan catabolic process (GO:0006569)3.95607264
46negative regulation of defense response to virus (GO:0050687)3.90353430
47ncRNA catabolic process (GO:0034661)3.85142349
48phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.85093084
49positive regulation of mitochondrial fission (GO:0090141)3.81505680
50nerve growth factor signaling pathway (GO:0038180)3.74370412
51regulation of memory T cell differentiation (GO:0043380)3.74087543
52positive regulation of fatty acid beta-oxidation (GO:0032000)3.73910897
53positive regulation of DNA-templated transcription, elongation (GO:0032786)3.67349164
54synaptonemal complex assembly (GO:0007130)3.66023875
55amino-acid betaine metabolic process (GO:0006577)3.61910348
56rRNA methylation (GO:0031167)3.57527550
57mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.57022965
58positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.57022965
59positive regulation of digestive system process (GO:0060456)3.49710479
60exogenous drug catabolic process (GO:0042738)3.49415784
61positive regulation of triglyceride metabolic process (GO:0090208)3.49406086
62regulation of meiosis I (GO:0060631)3.46618593
63protein K63-linked deubiquitination (GO:0070536)3.44301269
64carnitine transmembrane transport (GO:1902603)3.43599396
65autophagic vacuole assembly (GO:0000045)3.43390352
66negative regulation of fatty acid metabolic process (GO:0045922)3.43241877
67purine nucleobase biosynthetic process (GO:0009113)3.40642515
68cellular protein catabolic process (GO:0044257)3.37784355
69protein K48-linked deubiquitination (GO:0071108)3.36827862
70Golgi to endosome transport (GO:0006895)3.32496030
71peptidyl-lysine methylation (GO:0018022)3.28875779
72mitochondrial fragmentation involved in apoptotic process (GO:0043653)3.28829047
73phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.25528401
74synaptonemal complex organization (GO:0070193)3.20580730
75folic acid-containing compound biosynthetic process (GO:0009396)3.17896323
76carnitine transport (GO:0015879)3.17142112
77amino-acid betaine transport (GO:0015838)3.17142112
78nucleobase biosynthetic process (GO:0046112)3.16546648
79positive regulation of fatty acid oxidation (GO:0046321)3.15647059
80regulation of mitochondrial fission (GO:0090140)3.13757565
81positive regulation of systemic arterial blood pressure (GO:0003084)3.13154658
82tryptophan metabolic process (GO:0006568)3.12980539
83regulation of histone H3-K4 methylation (GO:0051569)3.09859604
84telencephalon development (GO:0021537)3.08890477
85negative regulation of Rho protein signal transduction (GO:0035024)3.08574717
86N-acetylglucosamine metabolic process (GO:0006044)3.07918263
87temperature homeostasis (GO:0001659)3.01840896
88negative regulation of meiosis (GO:0045835)3.01027371
89drug catabolic process (GO:0042737)3.00509982
90regulation of protein kinase A signaling (GO:0010738)2.98334473
91fatty acid transmembrane transport (GO:1902001)2.94087588
92negative regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043124)2.92758662
93toxin transport (GO:1901998)2.90325111
94positive regulation of dendritic spine development (GO:0060999)2.89889875
95positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.89551560
96rRNA modification (GO:0000154)2.89179574
97regulation of synapse structural plasticity (GO:0051823)2.89134376
98histone H3-K4 methylation (GO:0051568)2.84536469
99meiotic chromosome segregation (GO:0045132)11.9837509
100snRNA processing (GO:0016180)10.1022147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.84862466
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.24502551
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.14479832
4GBX2_23144817_ChIP-Seq_PC3_Human3.09707958
5PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.85102874
6TAF15_26573619_Chip-Seq_HEK293_Human2.83606609
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67403710
8DROSHA_22980978_ChIP-Seq_HELA_Human2.59995493
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.52923007
10EWS_26573619_Chip-Seq_HEK293_Human2.43622821
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.20077466
12TCF4_18268006_ChIP-ChIP_LS174T_Human2.01738902
13TCF4_23295773_ChIP-Seq_U87_Human1.86460090
14RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84209755
15FLI1_27457419_Chip-Seq_LIVER_Mouse1.84200077
16HOXB7_26014856_ChIP-Seq_BT474_Human1.79470330
17VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.77984621
18GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.71342440
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67559931
20WDR5_24793694_ChIP-Seq_LNCAP_Human1.64928547
21CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64334146
22ER_23166858_ChIP-Seq_MCF-7_Human1.64231238
23CBP_20019798_ChIP-Seq_JUKART_Human1.63514875
24IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.63514875
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63492560
26ETV2_25802403_ChIP-Seq_MESCs_Mouse1.62508639
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.60743099
28ZNF274_21170338_ChIP-Seq_K562_Hela1.60136996
29CJUN_26792858_Chip-Seq_BT549_Human1.59865759
30EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58779853
31POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.57742920
32TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57742920
33AR_21572438_ChIP-Seq_LNCaP_Human1.53652772
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52513804
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52093002
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.52005813
37BCAT_22108803_ChIP-Seq_LS180_Human1.49171992
38AR_20517297_ChIP-Seq_VCAP_Human1.47051459
39CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.44642681
40PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.44617198
41FUS_26573619_Chip-Seq_HEK293_Human1.43753834
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.43411807
43TFEB_21752829_ChIP-Seq_HELA_Human1.42423516
44PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41590151
45CDX2_22108803_ChIP-Seq_LS180_Human1.37028581
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.36590809
47JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.35212423
48RBPJ_21746931_ChIP-Seq_IB4_Human1.31372652
49TP53_22573176_ChIP-Seq_HFKS_Human1.31355549
50FOXA1_25329375_ChIP-Seq_VCAP_Human1.30963406
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.30963406
52OCT1_27270436_Chip-Seq_PROSTATE_Human1.30624808
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28092325
54ETV1_20927104_ChIP-Seq_GIST48_Human1.27365981
55FOXA1_21572438_ChIP-Seq_LNCaP_Human1.26475719
56RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25881193
57GF1_26923725_Chip-Seq_HPCs_Mouse1.25399180
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20420821
59ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20191766
60MYC_18940864_ChIP-ChIP_HL60_Human1.19808091
61MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19722922
62VDR_24787735_ChIP-Seq_THP-1_Human1.19038860
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18889016
64IRF1_19129219_ChIP-ChIP_H3396_Human1.17593635
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16338804
66TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15909904
67CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15281554
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14404347
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.14292269
70PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13913550
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.13897261
72SMAD4_21741376_ChIP-Seq_EPCs_Human1.12831267
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12222383
74IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.11586811
75AHR_22903824_ChIP-Seq_MCF-7_Human1.10841564
76FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10610870
77FOXH1_21741376_ChIP-Seq_EPCs_Human1.10540806
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.10042865
79LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09664590
80CBX2_22325352_ChIP-Seq_293T-Rex_Human1.09375876
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08575893
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.08106384
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06854090
84P300_19829295_ChIP-Seq_ESCs_Human1.05763352
85VDR_22108803_ChIP-Seq_LS180_Human1.05438360
86RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05339155
87CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04790300
88P53_21459846_ChIP-Seq_SAOS-2_Human1.04125366
89PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03788318
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03381441
91JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03266760
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.00567456
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.00127161
94AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97587863
95GATA3_26560356_Chip-Seq_TH1_Human0.96831103
96SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95486651
97FOXA1_25552417_ChIP-Seq_VCAP_Human0.95423380
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.95334124
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95041037
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.94361565

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005310_abnormal_salivary_gland5.35416281
2MP0004484_altered_response_of4.45629429
3MP0005085_abnormal_gallbladder_physiolo3.95986893
4MP0005646_abnormal_pituitary_gland3.68864027
5MP0001986_abnormal_taste_sensitivity3.29926788
6MP0005167_abnormal_blood-brain_barrier3.19974300
7MP0009764_decreased_sensitivity_to3.11008817
8MP0009780_abnormal_chondrocyte_physiolo2.78203121
9MP0003195_calcinosis2.76170564
10MP0006072_abnormal_retinal_apoptosis2.72682044
11MP0003011_delayed_dark_adaptation2.67611073
12MP0003646_muscle_fatigue2.65075813
13MP0005365_abnormal_bile_salt2.56979965
14MP0002876_abnormal_thyroid_physiology2.39053562
15MP0002138_abnormal_hepatobiliary_system2.30947124
16MP0008875_abnormal_xenobiotic_pharmacok2.22222127
17MP0009643_abnormal_urine_homeostasis2.13316667
18MP0005360_urolithiasis1.99763507
19MP0004215_abnormal_myocardial_fiber1.91653280
20MP0005551_abnormal_eye_electrophysiolog1.83375563
21MP0004742_abnormal_vestibular_system1.81178131
22MP0008872_abnormal_physiological_respon1.80763038
23MP0005253_abnormal_eye_physiology1.78041914
24MP0004130_abnormal_muscle_cell1.73849665
25MP0005332_abnormal_amino_acid1.73012147
26MP0004084_abnormal_cardiac_muscle1.65718293
27MP0001764_abnormal_homeostasis1.64695048
28MP0002693_abnormal_pancreas_physiology1.61678928
29MP0009745_abnormal_behavioral_response1.61430413
30MP0005165_increased_susceptibility_to1.55192039
31MP0008775_abnormal_heart_ventricle1.53808516
32MP0003136_yellow_coat_color1.51227137
33MP0004043_abnormal_pH_regulation1.48749195
34MP0004885_abnormal_endolymph1.48061478
35MP0004883_abnormal_blood_vessel1.47706865
36MP0003221_abnormal_cardiomyocyte_apopto1.45412009
37MP0002127_abnormal_cardiovascular_syste1.44222264
38MP0005410_abnormal_fertilization1.43324082
39MP0003045_fibrosis1.42820412
40MP0005423_abnormal_somatic_nervous1.42448162
41MP0004782_abnormal_surfactant_physiolog1.37669731
42MP0001348_abnormal_lacrimal_gland1.23436591
43MP0002928_abnormal_bile_duct1.19051776
44MP0001324_abnormal_eye_pigmentation1.17882046
45MP0001756_abnormal_urination1.14339991
46MP0000631_abnormal_neuroendocrine_gland1.13129983
47MP0003718_maternal_effect1.12085505
48MP0002136_abnormal_kidney_physiology1.11165270
49MP0001501_abnormal_sleep_pattern1.10224720
50MP0008469_abnormal_protein_level1.06824204
51MP0004233_abnormal_muscle_weight1.02499437
52MP0004085_abnormal_heartbeat1.01092085
53MP0005647_abnormal_sex_gland1.00816813
54MP0003879_abnormal_hair_cell1.00060959
55MP0002168_other_aberrant_phenotype0.96429699
56MP0010329_abnormal_lipoprotein_level0.96158827
57MP0005164_abnormal_response_to0.95216915
58MP0001666_abnormal_nutrient_absorption0.95173271
59MP0000383_abnormal_hair_follicle0.92929141
60MP0000230_abnormal_systemic_arterial0.92776108
61MP0000427_abnormal_hair_cycle0.91273623
62MP0003638_abnormal_response/metabolism_0.91254645
63MP0001970_abnormal_pain_threshold0.90805457
64MP0005330_cardiomyopathy0.89869574
65MP0010368_abnormal_lymphatic_system0.88250685
66MP0008877_abnormal_DNA_methylation0.86641962
67MP0002837_dystrophic_cardiac_calcinosis0.85436004
68MP0002089_abnormal_postnatal_growth/wei0.84393659
69MP0001502_abnormal_circadian_rhythm0.83569202
70MP0005376_homeostasis/metabolism_phenot0.82961816
71MP0005395_other_phenotype0.82669552
72MP0002118_abnormal_lipid_homeostasis0.82486449
73MP0000372_irregular_coat_pigmentation0.81788196
74MP0002557_abnormal_social/conspecific_i0.81004458
75MP0001765_abnormal_ion_homeostasis0.80949495
76MP0002078_abnormal_glucose_homeostasis0.80266122
77MP0005409_darkened_coat_color0.80199748
78MP0002733_abnormal_thermal_nociception0.78968270
79MP0000609_abnormal_liver_physiology0.78546563
80MP0003868_abnormal_feces_composition0.77946669
81MP0001958_emphysema0.77379074
82MP0002723_abnormal_immune_serum0.77333648
83MP0005448_abnormal_energy_balance0.77089115
84MP0005645_abnormal_hypothalamus_physiol0.75445604
85MP0005220_abnormal_exocrine_pancreas0.75276275
86MP0001800_abnormal_humoral_immune0.73449820
87MP0004381_abnormal_hair_follicle0.73118552
88MP0004036_abnormal_muscle_relaxation0.71217511
89MP0001845_abnormal_inflammatory_respons0.70569286
90MP0006054_spinal_hemorrhage0.69994787
91MP0000249_abnormal_blood_vessel0.69486506
92MP0005000_abnormal_immune_tolerance0.69422205
93MP0002139_abnormal_hepatobiliary_system0.66596488
94MP0002254_reproductive_system_inflammat0.63569638
95MP0009697_abnormal_copulation0.63511852
96MP0002972_abnormal_cardiac_muscle0.62370129
97MP0005595_abnormal_vascular_smooth0.62031357
98MP0002075_abnormal_coat/hair_pigmentati0.59567775
99MP0002064_seizures0.58685240
100MP0002210_abnormal_sex_determination0.57440988

Predicted human phenotypes

RankGene SetZ-score
1Decreased circulating renin level (HP:0003351)9.23816959
2Pigmentary retinal degeneration (HP:0001146)6.78472453
3Polydipsia (HP:0001959)5.67789973
4Abnormal drinking behavior (HP:0030082)5.67789973
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.67773802
6Chronic bronchitis (HP:0004469)5.55714959
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.11065742
8Abnormality of renin-angiotensin system (HP:0000847)5.08263343
9Choroideremia (HP:0001139)4.79668934
10Abnormal rod and cone electroretinograms (HP:0008323)4.73933590
11Flat occiput (HP:0005469)4.64295303
12Decreased central vision (HP:0007663)4.15668009
13Polyuria (HP:0000103)4.03093867
14Attenuation of retinal blood vessels (HP:0007843)3.99535986
15Thyroid-stimulating hormone excess (HP:0002925)3.62159533
16Hyperkalemia (HP:0002153)3.60849167
17Bony spicule pigmentary retinopathy (HP:0007737)3.46321848
18Abnormal urine output (HP:0012590)3.39627984
19Abnormality of incisor morphology (HP:0011063)3.32174935
20Rimmed vacuoles (HP:0003805)3.25115033
21Conical tooth (HP:0000698)3.21571031
22Recurrent otitis media (HP:0000403)3.18989521
23Severe Myopia (HP:0011003)3.12288426
24Long toe (HP:0010511)3.01607225
25Biliary tract neoplasm (HP:0100574)2.98332310
26Bile duct proliferation (HP:0001408)2.96118817
27Abnormal biliary tract physiology (HP:0012439)2.96118817
28Hypokalemic alkalosis (HP:0001949)2.94334648
29Hypoplastic nipples (HP:0002557)2.88820957
30Bronchitis (HP:0012387)2.86507366
31Abnormality of renal excretion (HP:0011036)2.84156217
32Hyponatremia (HP:0002902)2.82464940
33Congenital stationary night blindness (HP:0007642)2.74846110
34Abnormality of alanine metabolism (HP:0010916)2.69881221
35Hyperalaninemia (HP:0003348)2.69881221
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69881221
37Hypocalcemia (HP:0002901)2.66383832
38Pancreatic cysts (HP:0001737)2.61452014
39Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.60881128
40Hyperactive renin-angiotensin system (HP:0000841)2.58671289
41True hermaphroditism (HP:0010459)2.56997599
42Limb-girdle muscle atrophy (HP:0003797)2.55271324
43Sleep apnea (HP:0010535)2.49016018
44Increased neuronal autofluorescent lipopigment (HP:0002074)2.45487865
45Chronic hepatic failure (HP:0100626)2.44193556
46Hyperaldosteronism (HP:0000859)2.42583723
47Abnormality of sodium homeostasis (HP:0010931)2.42503740
482-3 toe syndactyly (HP:0004691)2.41758316
49Abnormality of chloride homeostasis (HP:0011422)2.34919969
50Broad-based gait (HP:0002136)2.21456363
51Retrobulbar optic neuritis (HP:0100654)2.20270391
52Optic neuritis (HP:0100653)2.20270391
53Pancreatic fibrosis (HP:0100732)2.16974301
54Molar tooth sign on MRI (HP:0002419)2.14139306
55Abnormality of midbrain morphology (HP:0002418)2.14139306
56Gaze-evoked nystagmus (HP:0000640)2.13488899
57Rhinitis (HP:0012384)2.11847107
58Neoplasm of the heart (HP:0100544)2.09799415
59Ketoacidosis (HP:0001993)2.06939168
60Aplasia/Hypoplasia of the fovea (HP:0008060)2.06501305
61Hypoplasia of the fovea (HP:0007750)2.06501305
62Abnormality of glutamine family amino acid metabolism (HP:0010902)2.06063490
63Retinitis pigmentosa (HP:0000510)2.04335950
64Orchitis (HP:0100796)2.04304698
65Abnormal respiratory motile cilium physiology (HP:0012261)2.03942007
66Abnormality of T cell physiology (HP:0011840)2.01414983
67Clumsiness (HP:0002312)2.01007741
68Abnormality of potassium homeostasis (HP:0011042)1.96027500
69Skin nodule (HP:0200036)1.92943599
70Abnormality of the pons (HP:0007361)1.91387344
71Increased cerebral lipofuscin (HP:0011813)1.89933681
72Photophobia (HP:0000613)1.89026052
73Renal salt wasting (HP:0000127)1.88422230
74Portal hypertension (HP:0001409)1.87104186
75Central scotoma (HP:0000603)1.86925104
76Ketosis (HP:0001946)1.85369081
77Abnormality of the renal cortex (HP:0011035)1.84268820
78Congenital hepatic fibrosis (HP:0002612)1.84179020
79Type II lissencephaly (HP:0007260)1.83914445
80Abnormal biliary tract morphology (HP:0012440)1.83720866
81Gonadal dysgenesis (HP:0000133)1.83028001
82Intrahepatic cholestasis (HP:0001406)1.81913754
83Myositis (HP:0100614)1.80998616
84Tubular atrophy (HP:0000092)1.80279303
85Hypomagnesemia (HP:0002917)1.80188440
86Hemoptysis (HP:0002105)1.79451225
87Focal seizures (HP:0007359)1.78665064
88Type II diabetes mellitus (HP:0005978)1.77855026
89Hypoplasia of the uterus (HP:0000013)1.77169386
90Abnormality of proline metabolism (HP:0010907)1.76957183
91Hydroxyprolinuria (HP:0003080)1.76957183
92Hypoplasia of the pons (HP:0012110)1.76827942
93Ependymoma (HP:0002888)1.76631457
94Abnormal delayed hypersensitivity skin test (HP:0002963)1.76169061
95Abnormality of the nasal septum (HP:0000419)1.75418858
96Bronchiectasis (HP:0002110)1.74204303
97Cerebellar dysplasia (HP:0007033)1.72480616
98Neoplasm of the rectum (HP:0100743)1.70301776
99Hypokalemia (HP:0002900)1.69354981
100Syncope (HP:0001279)1.67415483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.53853053
2CAMKK24.21323436
3FRK4.14084116
4CAMK1D3.58899455
5CAMK1G2.37124614
6PDK12.14851488
7PDPK12.06763042
8BLK11.3793405
9CAMK41.74107443
10EPHA41.69669307
11ZAK1.62517447
12HIPK21.53066185
13TXK1.52521867
14TNK21.47070536
15CAMKK11.34907791
16WNK41.31910663
17STK38L1.19017707
18RPS6KA41.15633567
19MAPKAPK51.10541714
20DYRK31.00896883
21STK390.94934323
22TLK10.90105397
23MELK0.89104218
24PINK10.86503027
25DAPK20.82556619
26OXSR10.82055265
27ADRBK20.79617334
28NUAK10.76984664
29MARK30.76953272
30MAPKAPK30.72264830
31PTK2B0.70721766
32EPHA30.68070326
33GRK50.65334155
34PRKCE0.60994478
35MAP4K20.60605675
36SRPK10.60390789
37RPS6KA60.59567822
38PRKAA20.58794694
39SGK20.57188762
40BMX0.55473432
41PRKD10.54256321
42CAMK10.53852075
43GRK10.51764867
44ERBB20.51625723
45BRD40.51567035
46GRK70.50821191
47GSK3A0.50708090
48IKBKB0.49920413
49LYN0.48362568
50CSNK1E0.47540210
51JAK30.47246308
52STK380.47220573
53ADRBK10.46263294
54CDK90.45856987
55ROCK10.43393053
56TGFBR20.43281717
57PRKCI0.43276731
58KSR10.42949030
59DYRK20.42484516
60NEK20.42200519
61TRPM70.42146917
62ITK0.41772730
63RPS6KL10.41501072
64RPS6KC10.41501072
65SGK10.40213963
66ACVR1B0.39622942
67FER0.39359466
68PDGFRB0.38098453
69RPS6KA20.38043490
70MAP3K50.37959591
71PRKG20.37512500
72KIT0.35809199
73RPS6KA50.34768314
74WNK10.34628412
75PKN10.33381975
76TAOK30.33170284
77MYLK0.32388169
78MAP3K40.30962518
79STK110.29546193
80STK30.27289272
81PRKCZ0.26172238
82PRKCQ0.24140027
83PRKD20.24088807
84SGK4940.23832374
85SGK2230.23832374
86ABL10.23264907
87CAMK2D0.23126982
88PRKG10.22054608
89JAK10.21975270
90PAK30.21869938
91WNK30.21793777
92LATS10.21094793
93CAMK2A0.20221820
94SGK30.19970304
95PRKAA10.19501574
96NLK0.18851422
97MAP2K60.18789968
98MAPK70.18531443
99EPHB20.18314534
100RPS6KA30.18073729

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of autophagy_Homo sapiens_hsa041405.05964574
2Caffeine metabolism_Homo sapiens_hsa002324.01210020
3Linoleic acid metabolism_Homo sapiens_hsa005913.89024764
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.58516806
5Propanoate metabolism_Homo sapiens_hsa006403.28025460
6Fatty acid degradation_Homo sapiens_hsa000712.53075857
7One carbon pool by folate_Homo sapiens_hsa006702.46388289
8Cysteine and methionine metabolism_Homo sapiens_hsa002702.31490379
9Selenocompound metabolism_Homo sapiens_hsa004502.21837927
10Staphylococcus aureus infection_Homo sapiens_hsa051502.16491690
11RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.14329632
12Fatty acid metabolism_Homo sapiens_hsa012122.02598183
13Ether lipid metabolism_Homo sapiens_hsa005651.92872594
14Pyruvate metabolism_Homo sapiens_hsa006201.91749223
15PPAR signaling pathway_Homo sapiens_hsa033201.84505173
16Tryptophan metabolism_Homo sapiens_hsa003801.69834337
17Sulfur metabolism_Homo sapiens_hsa009201.59626590
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.58347312
19FoxO signaling pathway_Homo sapiens_hsa040681.57149150
20Arachidonic acid metabolism_Homo sapiens_hsa005901.42558350
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.39525602
22Glucagon signaling pathway_Homo sapiens_hsa049221.37120779
23Ovarian steroidogenesis_Homo sapiens_hsa049131.30651011
24Asthma_Homo sapiens_hsa053101.26605923
25Lysine degradation_Homo sapiens_hsa003101.26218505
26Morphine addiction_Homo sapiens_hsa050321.23811240
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11965579
28Sulfur relay system_Homo sapiens_hsa041221.11627833
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.10715352
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.08647959
31Butanoate metabolism_Homo sapiens_hsa006501.04571809
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.00037636
33Allograft rejection_Homo sapiens_hsa053300.99408461
34Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.90310563
35Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89770881
36Taste transduction_Homo sapiens_hsa047420.88162552
37Phototransduction_Homo sapiens_hsa047440.87841707
38Insulin secretion_Homo sapiens_hsa049110.87493348
39Nitrogen metabolism_Homo sapiens_hsa009100.85526577
40Thyroid hormone synthesis_Homo sapiens_hsa049180.80726491
41Primary immunodeficiency_Homo sapiens_hsa053400.80265261
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79367217
43Jak-STAT signaling pathway_Homo sapiens_hsa046300.77995266
44Fat digestion and absorption_Homo sapiens_hsa049750.76613623
45Autoimmune thyroid disease_Homo sapiens_hsa053200.76502534
46Arginine biosynthesis_Homo sapiens_hsa002200.76470811
47Retinol metabolism_Homo sapiens_hsa008300.72496628
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.68844178
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68222443
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68159860
51MAPK signaling pathway_Homo sapiens_hsa040100.66756473
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.66594521
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.65651610
54Glutamatergic synapse_Homo sapiens_hsa047240.65560431
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65520531
56Renin secretion_Homo sapiens_hsa049240.64597247
57Insulin resistance_Homo sapiens_hsa049310.64326880
58Complement and coagulation cascades_Homo sapiens_hsa046100.64247390
59Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.63290552
60Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63136600
61Glycerophospholipid metabolism_Homo sapiens_hsa005640.61857840
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60930895
63Circadian rhythm_Homo sapiens_hsa047100.60740271
64Serotonergic synapse_Homo sapiens_hsa047260.60402574
65Bile secretion_Homo sapiens_hsa049760.58935469
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57085879
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56344416
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54421633
69Nicotine addiction_Homo sapiens_hsa050330.53178921
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.52856492
71Dilated cardiomyopathy_Homo sapiens_hsa054140.52522763
72Fatty acid biosynthesis_Homo sapiens_hsa000610.50764057
73GnRH signaling pathway_Homo sapiens_hsa049120.48757222
74Maturity onset diabetes of the young_Homo sapiens_hsa049500.47476893
75GABAergic synapse_Homo sapiens_hsa047270.47270071
76B cell receptor signaling pathway_Homo sapiens_hsa046620.47150585
77Arginine and proline metabolism_Homo sapiens_hsa003300.46909870
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45754915
79Mineral absorption_Homo sapiens_hsa049780.45489415
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45315941
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44477718
82Chemical carcinogenesis_Homo sapiens_hsa052040.44208318
83Salivary secretion_Homo sapiens_hsa049700.44200574
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42824211
85Calcium signaling pathway_Homo sapiens_hsa040200.42565307
86Oxytocin signaling pathway_Homo sapiens_hsa049210.42000111
87Salmonella infection_Homo sapiens_hsa051320.41744219
88Osteoclast differentiation_Homo sapiens_hsa043800.41040253
89Graft-versus-host disease_Homo sapiens_hsa053320.39965174
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39471244
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39004634
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38491533
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38072230
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.36176415
95Histidine metabolism_Homo sapiens_hsa003400.34995972
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.34602605
97Circadian entrainment_Homo sapiens_hsa047130.33945355
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33120913
99Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.31348019
100Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30608045

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