ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	meiosis I (GO:0007127)	9.19143076
2	DNA synthesis involved in DNA repair (GO:0000731)	8.81047962
3	meiotic nuclear division (GO:0007126)	8.10713204
4	synaptonemal complex assembly (GO:0007130)	7.72084496
5	synaptonemal complex organization (GO:0070193)	7.18540090
6	meiotic cell cycle process (GO:1903046)	5.54255769
7	reciprocal DNA recombination (GO:0035825)	5.51523187
8	reciprocal meiotic recombination (GO:0007131)	5.51523187
9	regulation of meiosis I (GO:0060631)	5.46748009
10	meiotic chromosome segregation (GO:0045132)	5.30061071
11	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc	4.91663814
12	regulation of activation of Janus kinase activity (GO:0010533)	4.84464718
13	cytidine catabolic process (GO:0006216)	4.51741399
14	cytidine deamination (GO:0009972)	4.51741399
15	cytidine metabolic process (GO:0046087)	4.51741399
16	negative regulation by host of viral transcription (GO:0043922)	4.46567456
17	sister chromatid cohesion (GO:0007062)	4.42277181
18	histone H3-K36 demethylation (GO:0070544)	4.31783289
19	eosinophil chemotaxis (GO:0048245)	4.18673074
20	histone H3-K9 demethylation (GO:0033169)	4.06623034
21	signal complex assembly (GO:0007172)	3.97296657
22	positive regulation of translational initiation (GO:0045948)	3.92425333
23	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.91252371
24	resolution of meiotic recombination intermediates (GO:0000712)	3.90720591
25	positive regulation of meiosis (GO:0045836)	3.89905387
26	DNA alkylation (GO:0006305)	3.80439089
27	DNA methylation (GO:0006306)	3.80439089
28	gene silencing by RNA (GO:0031047)	3.80144353
29	regulation of DNA endoreduplication (GO:0032875)	3.77488194
30	eosinophil migration (GO:0072677)	3.74073903
31	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.72815239
32	positive regulation of meiotic cell cycle (GO:0051446)	3.60547182
33	retinal cone cell development (GO:0046549)	3.54416563
34	attachment of spindle microtubules to kinetochore (GO:0008608)	3.50188789
35	negative regulation of gene silencing (GO:0060969)	3.47526851
36	negative regulation of inclusion body assembly (GO:0090084)	3.43969895
37	regulation of chronic inflammatory response (GO:0002676)	3.40208693
38	DNA methylation or demethylation (GO:0044728)	3.35090795
39	female gamete generation (GO:0007292)	3.34432157
40	positive regulation of T cell cytokine production (GO:0002726)	3.30417728
41	proteasome assembly (GO:0043248)	3.27227468
42	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.25614859
43	mismatch repair (GO:0006298)	3.23893837
44	spermatid development (GO:0007286)	3.21884228
45	histone H4-K12 acetylation (GO:0043983)	3.18007489
46	positive regulation of response to oxidative stress (GO:1902884)	3.15658447
47	positive regulation of cellular response to oxidative stress (GO:1900409)	3.15658447
48	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	3.10959737
49	diterpenoid biosynthetic process (GO:0016102)	3.01990834
50	striatum development (GO:0021756)	2.97419300
51	regulation of meiotic cell cycle (GO:0051445)	2.94524665
52	negative regulation of mast cell activation (GO:0033004)	2.93553792
53	DNA modification (GO:0006304)	2.91226909
54	terpenoid biosynthetic process (GO:0016114)	2.89687652
55	iron-sulfur cluster assembly (GO:0016226)	2.86696993
56	metallo-sulfur cluster assembly (GO:0031163)	2.86696993
57	organic cation transport (GO:0015695)	2.86154498
58	regulation of chemokine-mediated signaling pathway (GO:0070099)	2.81229583
59	monocyte chemotaxis (GO:0002548)	2.77268429
60	regulation of memory T cell differentiation (GO:0043380)	2.76024406
61	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	2.75610248
62	retinal metabolic process (GO:0042574)	2.75475810
63	growth hormone receptor signaling pathway (GO:0060396)	2.73141049
64	cellular response to interleukin-15 (GO:0071350)	2.72234172
65	modulation by host of symbiont transcription (GO:0052472)	2.72021646
66	modulation by host of viral transcription (GO:0043921)	2.72021646
67	modulation of transcription in other organism involved in symbiotic interaction (GO:0052312)	2.71155131
68	positive regulation of T cell chemotaxis (GO:0010820)	2.68707573
69	regulation of T cell chemotaxis (GO:0010819)	2.68707573
70	DNA deamination (GO:0045006)	2.67186042
71	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.66732186
72	isotype switching (GO:0045190)	2.66732186
73	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.66732186
74	protein refolding (GO:0042026)	2.65739630
75	mitotic sister chromatid cohesion (GO:0007064)	2.63610579
76	positive regulation of T cell apoptotic process (GO:0070234)	2.62861501
77	embryonic body morphogenesis (GO:0010172)	2.60588360
78	protein peptidyl-prolyl isomerization (GO:0000413)	2.59500560
79	viral genome replication (GO:0019079)	2.58439502
80	regulation of mononuclear cell migration (GO:0071675)	2.58347218
81	behavioral response to nicotine (GO:0035095)	2.57961784
82	regulation of histone H3-K9 methylation (GO:0051570)	2.56619136
83	sex differentiation (GO:0007548)	2.55758785
84	positive regulation of monocyte chemotaxis (GO:0090026)	2.55208638
85	protein localization to chromosome (GO:0034502)	2.54676945
86	regulation of cilium movement (GO:0003352)	2.51438150
87	autophagic vacuole fusion (GO:0000046)	2.49683663
88	germ cell development (GO:0007281)	2.48552544
89	histone H2A acetylation (GO:0043968)	2.46589158
90	regulation of microtubule-based movement (GO:0060632)	2.44550919
91	nonmotile primary cilium assembly (GO:0035058)	2.44053920
92	cellular response to growth hormone stimulus (GO:0071378)	2.42159652
93	regulation of immunoglobulin secretion (GO:0051023)	2.40900562
94	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.39555467
95	synapsis (GO:0007129)	15.2975365
96	male meiosis I (GO:0007141)	11.2964242
97	piRNA metabolic process (GO:0034587)	10.9370695
98	chromosome organization involved in meiosis (GO:0070192)	10.4478970
99	DNA methylation involved in gamete generation (GO:0043046)	10.1223836
100	male meiosis (GO:0007140)	10.0441585

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.77112732
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	3.54651092
3	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.43244661
4	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	3.28691580
5	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.14804127
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.75926103
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.51792263
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.45631454
9	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.35807040
10	TP53_22573176_ChIP-Seq_HFKS_Human	2.32488257
11	RNF2_27304074_Chip-Seq_NSC_Mouse	2.29706521
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.23973494
13	FUS_26573619_Chip-Seq_HEK293_Human	2.17891084
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.16442274
15	VDR_22108803_ChIP-Seq_LS180_Human	2.10681773
16	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	2.05363199
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.98471604
18	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.92663461
19	MYC_18940864_ChIP-ChIP_HL60_Human	1.92558494
20	TP53_16413492_ChIP-PET_HCT116_Human	1.88863447
21	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.82702452
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.77492357
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.77024015
24	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.74587210
25	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.74587210
26	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.70434906
27	P300_19829295_ChIP-Seq_ESCs_Human	1.67252083
28	ELK1_19687146_ChIP-ChIP_HELA_Human	1.65264135
29	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.65189121
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.64083475
31	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.63579430
32	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.60028446
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.59195685
34	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.54818547
35	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.54779246
36	GBX2_23144817_ChIP-Seq_PC3_Human	1.54145396
37	EWS_26573619_Chip-Seq_HEK293_Human	1.53148839
38	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.48370077
39	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.47960393
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47110358
41	HTT_18923047_ChIP-ChIP_STHdh_Human	1.46792938
42	AR_25329375_ChIP-Seq_VCAP_Human	1.46394128
43	AR_20517297_ChIP-Seq_VCAP_Human	1.45771863
44	VDR_23849224_ChIP-Seq_CD4+_Human	1.44786015
45	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.43694143
46	RUNX_20019798_ChIP-Seq_JUKART_Human	1.43676523
47	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.37968247
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.36007336
49	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.35421562
50	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.34934623
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.30505187
52	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.28318562
53	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.26924975
54	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.25896617
55	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.23888220
56	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	1.23465623
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23321982
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22900410
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21353038
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21353038
61	PHF8_20622853_ChIP-Seq_HELA_Human	1.21344800
62	GATA3_26560356_Chip-Seq_TH1_Human	1.19982232
63	RUNX2_22187159_ChIP-Seq_PCA_Human	1.19870763
64	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19594577
65	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.19408925
66	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.18785407
67	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.18003453
68	TCF4_23295773_ChIP-Seq_U87_Human	1.17775580
69	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.17299606
70	NFYB_21822215_ChIP-Seq_K562_Human	1.16901100
71	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.15348455
72	TCF4_22108803_ChIP-Seq_LS180_Human	1.14904983
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.14672422
74	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12568991
75	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.12527315
76	STAT3_23295773_ChIP-Seq_U87_Human	1.12286306
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.11606260
78	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.11124082
79	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09541925
80	CBP_20019798_ChIP-Seq_JUKART_Human	1.09541925
81	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.08494873
82	ERA_21632823_ChIP-Seq_H3396_Human	1.07631885
83	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.06470197
84	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.06327512
85	RXR_22108803_ChIP-Seq_LS180_Human	1.05901744
86	RBPJ_21746931_ChIP-Seq_IB4_Human	1.04314792
87	ETV1_20927104_ChIP-Seq_GIST48_Human	1.02358502
88	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.01931074
89	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.00988957
90	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99982661
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.99793689
92	TBL1_22424771_ChIP-Seq_293T_Human	0.99721790
93	NCOR_22424771_ChIP-Seq_293T_Human	0.99486471
94	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.99402107
95	CDX2_22108803_ChIP-Seq_LS180_Human	0.99054451
96	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.97353028
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96938096
98	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.96646281
99	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.96207288
100	GATA3_26560356_Chip-Seq_TH2_Human	0.96076935

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	8.29623342
2	MP0000569_abnormal_digit_pigmentation	4.15655378
3	MP0000427_abnormal_hair_cycle	3.37237084
4	MP0000383_abnormal_hair_follicle	3.29946626
5	MP0002210_abnormal_sex_determination	3.28237755
6	MP0002160_abnormal_reproductive_system	3.17911416
7	MP0003195_calcinosis	3.17295322
8	MP0008058_abnormal_DNA_repair	3.04213843
9	MP0001929_abnormal_gametogenesis	2.64565159
10	MP0006082_CNS_inflammation	2.60422427
11	MP0005174_abnormal_tail_pigmentation	2.55143543
12	MP0000015_abnormal_ear_pigmentation	2.51675139
13	MP0002095_abnormal_skin_pigmentation	2.50435687
14	MP0005389_reproductive_system_phenotype	2.50351950
15	MP0009379_abnormal_foot_pigmentation	2.31971482
16	MP0003693_abnormal_embryo_hatching	2.31243711
17	MP0010678_abnormal_skin_adnexa	2.22291737
18	MP0001145_abnormal_male_reproductive	2.20481504
19	MP0008995_early_reproductive_senescence	2.12128156
20	MP0000653_abnormal_sex_gland	2.09064002
21	MP0003698_abnormal_male_reproductive	2.05966795
22	MP0001188_hyperpigmentation	2.01619622
23	MP0002876_abnormal_thyroid_physiology	1.99770745
24	MP0001119_abnormal_female_reproductive	1.74320752
25	MP0001661_extended_life_span	1.73459311
26	MP0005671_abnormal_response_to	1.71107338
27	MP0001501_abnormal_sleep_pattern	1.68714225
28	MP0002638_abnormal_pupillary_reflex	1.60510111
29	MP0003183_abnormal_peptide_metabolism	1.57333249
30	MP0003786_premature_aging	1.56968663
31	MP0002822_catalepsy	1.54938418
32	MP0002909_abnormal_adrenal_gland	1.54829002
33	MP0003763_abnormal_thymus_physiology	1.46187031
34	MP0005310_abnormal_salivary_gland	1.37251861
35	MP0001919_abnormal_reproductive_system	1.35628744
36	MP0003646_muscle_fatigue	1.34993296
37	MP0000647_abnormal_sebaceous_gland	1.34619450
38	MP0008007_abnormal_cellular_replicative	1.27423308
39	MP0001502_abnormal_circadian_rhythm	1.25105486
40	MP0002163_abnormal_gland_morphology	1.24766158
41	MP0001764_abnormal_homeostasis	1.15294246
42	MP0004742_abnormal_vestibular_system	1.14661215
43	MP0004043_abnormal_pH_regulation	1.14101292
44	MP0000465_gastrointestinal_hemorrhage	1.11681627
45	MP0001243_abnormal_dermal_layer	1.09679803
46	MP0010094_abnormal_chromosome_stability	1.06657703
47	MP0003699_abnormal_female_reproductive	1.03848898
48	MP0010307_abnormal_tumor_latency	1.03382476
49	MP0001346_abnormal_lacrimal_gland	1.01154520
50	MP0001984_abnormal_olfaction	0.98638725
51	MP0002277_abnormal_respiratory_mucosa	0.97322067
52	MP0005645_abnormal_hypothalamus_physiol	0.96679726
53	MP0009333_abnormal_splenocyte_physiolog	0.94735177
54	MP0003718_maternal_effect	0.93937529
55	MP0002161_abnormal_fertility/fecundity	0.93767370
56	MP0005646_abnormal_pituitary_gland	0.89873131
57	MP0002148_abnormal_hypersensitivity_rea	0.88160730
58	MP0005084_abnormal_gallbladder_morpholo	0.86818380
59	MP0001800_abnormal_humoral_immune	0.86386212
60	MP0008057_abnormal_DNA_replication	0.81636568
61	MP0000778_abnormal_nervous_system	0.79475888
62	MP0005410_abnormal_fertilization	0.78048796
63	MP0002139_abnormal_hepatobiliary_system	0.77462682
64	MP0005551_abnormal_eye_electrophysiolog	0.74452901
65	MP0005000_abnormal_immune_tolerance	0.74439788
66	MP0009745_abnormal_behavioral_response	0.73398663
67	MP0005409_darkened_coat_color	0.70341750
68	MP0008872_abnormal_physiological_respon	0.68407034
69	MP0009785_altered_susceptibility_to	0.68196693
70	MP0002272_abnormal_nervous_system	0.68154185
71	MP0002723_abnormal_immune_serum	0.67765449
72	MP0005253_abnormal_eye_physiology	0.65497132
73	MP0001191_abnormal_skin_condition	0.65183433
74	MP0003880_abnormal_central_pattern	0.64720491
75	MP0006276_abnormal_autonomic_nervous	0.63068013
76	MP0001486_abnormal_startle_reflex	0.62888567
77	MP0003136_yellow_coat_color	0.62236583
78	MP0002928_abnormal_bile_duct	0.61263427
79	MP0010386_abnormal_urinary_bladder	0.61103886
80	MP0005332_abnormal_amino_acid	0.59857220
81	MP0000013_abnormal_adipose_tissue	0.59134440
82	MP0002102_abnormal_ear_morphology	0.58703865
83	MP0005386_behavior/neurological_phenoty	0.57802761
84	MP0004924_abnormal_behavior	0.57802761
85	MP0002693_abnormal_pancreas_physiology	0.56688852
86	MP0005387_immune_system_phenotype	0.55823541
87	MP0001790_abnormal_immune_system	0.55823541
88	MP0002405_respiratory_system_inflammati	0.55056118
89	MP0000685_abnormal_immune_system	0.54244990
90	MP0003123_paternal_imprinting	0.53023288
91	MP0006035_abnormal_mitochondrial_morpho	0.52632546
92	MP0003119_abnormal_digestive_system	0.50377282
93	MP0008004_abnormal_stomach_pH	0.50300856
94	MP0000689_abnormal_spleen_morphology	0.49503177
95	MP0001905_abnormal_dopamine_level	0.48949342
96	MP0004885_abnormal_endolymph	0.47976223
97	MP0002420_abnormal_adaptive_immunity	0.47486465
98	MP0001666_abnormal_nutrient_absorption	0.47416632
99	MP0002971_abnormal_brown_adipose	0.46976248
100	MP0001529_abnormal_vocalization	0.46930436

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Oligodactyly (hands) (HP:0001180)	4.69757573
2	Amyotrophic lateral sclerosis (HP:0007354)	4.42162494
3	Volvulus (HP:0002580)	4.32608518
4	Shoulder girdle muscle weakness (HP:0003547)	4.10843174
5	Rimmed vacuoles (HP:0003805)	3.76192158
6	Congenital, generalized hypertrichosis (HP:0004540)	3.75729392
7	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	3.75229251
8	Abnormal protein N-linked glycosylation (HP:0012347)	3.75229251
9	Abnormal protein glycosylation (HP:0012346)	3.75229251
10	Abnormal glycosylation (HP:0012345)	3.75229251
11	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.69289883
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.69289883
13	Type I transferrin isoform profile (HP:0003642)	3.46025564
14	Hyperkalemia (HP:0002153)	3.36897601
15	Abnormality of T cell number (HP:0011839)	3.34056399
16	Upper motor neuron abnormality (HP:0002127)	3.32617828
17	Abnormality of the renal cortex (HP:0011035)	3.27956136
18	Horizontal nystagmus (HP:0000666)	3.27419930
19	Abnormality of the lower motor neuron (HP:0002366)	3.22298121
20	Abnormality of midbrain morphology (HP:0002418)	3.19623388
21	Molar tooth sign on MRI (HP:0002419)	3.19623388
22	Absent speech (HP:0001344)	3.06628364
23	Cutaneous melanoma (HP:0012056)	3.05407674
24	Facial hemangioma (HP:0000329)	2.85251266
25	Abnormality of DNA repair (HP:0003254)	2.82452210
26	Oligodactyly (HP:0012165)	2.80911777
27	Medial flaring of the eyebrow (HP:0010747)	2.78231383
28	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.75403445
29	11 pairs of ribs (HP:0000878)	2.71956454
30	T lymphocytopenia (HP:0005403)	2.71731459
31	Abnormality of the renal medulla (HP:0100957)	2.69445147
32	Abnormality of T cells (HP:0002843)	2.69169924
33	Entropion (HP:0000621)	2.64988141
34	B lymphocytopenia (HP:0010976)	2.62206677
35	Ectopic kidney (HP:0000086)	2.60023402
36	Nephronophthisis (HP:0000090)	2.58195948
37	Tubulointerstitial nephritis (HP:0001970)	2.55241380
38	Congenital primary aphakia (HP:0007707)	2.53314781
39	Abnormality of the corticospinal tract (HP:0002492)	2.52444994
40	Gait imbalance (HP:0002141)	2.50172752
41	Azoospermia (HP:0000027)	2.46731946
42	Fair hair (HP:0002286)	2.44623840
43	Abnormality of B cell number (HP:0010975)	2.44350860
44	Pili torti (HP:0003777)	2.42752147
45	Neurodegeneration (HP:0002180)	2.42178987
46	Follicular hyperkeratosis (HP:0007502)	2.40296679
47	Nephrogenic diabetes insipidus (HP:0009806)	2.38215454
48	Generalized hypopigmentation of hair (HP:0011358)	2.37793519
49	J-shaped sella turcica (HP:0002680)	2.37270076
50	Abnormality of T cell physiology (HP:0011840)	2.35509774
51	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.35468076
52	Abnormality of alanine metabolism (HP:0010916)	2.35468076
53	Hyperalaninemia (HP:0003348)	2.35468076
54	Basal cell carcinoma (HP:0002671)	2.34533775
55	Gonadotropin excess (HP:0000837)	2.34160228
56	Capillary hemangiomas (HP:0005306)	2.33321303
57	Methylmalonic acidemia (HP:0002912)	2.32962808
58	Atrophy/Degeneration involving motor neurons (HP:0007373)	2.24209207
59	Abnormality of the vocal cords (HP:0008777)	2.23798025
60	Pancreatic cysts (HP:0001737)	2.23513745
61	Brushfield spots (HP:0001088)	2.17924308
62	Hypoplastic labia majora (HP:0000059)	2.17514741
63	Congenital stationary night blindness (HP:0007642)	2.16713975
64	Renal cortical cysts (HP:0000803)	2.16389283
65	Poikiloderma (HP:0001029)	2.16188314
66	Type II lissencephaly (HP:0007260)	2.13324668
67	Abnormality of eosinophils (HP:0001879)	2.07771295
68	Multicystic kidney dysplasia (HP:0000003)	2.05912330
69	Autoimmune hemolytic anemia (HP:0001890)	2.03513237
70	Ureteral stenosis (HP:0000071)	2.00529850
71	Severe combined immunodeficiency (HP:0004430)	1.97270606
72	Abnormality of the labia majora (HP:0012881)	1.95288852
73	IgG deficiency (HP:0004315)	1.93466969
74	Carpal bone hypoplasia (HP:0001498)	1.91516991
75	Colon cancer (HP:0003003)	1.90903267
76	Non-midline cleft lip (HP:0100335)	1.90169741
77	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.89953695
78	Supernumerary spleens (HP:0009799)	1.89662770
79	Deformed sella turcica (HP:0002681)	1.88582540
80	Poor coordination (HP:0002370)	1.85566986
81	Abnormal spermatogenesis (HP:0008669)	1.85289458
82	Combined immunodeficiency (HP:0005387)	1.84999162
83	Cerebellar dysplasia (HP:0007033)	1.82335722
84	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.81904649
85	Methylmalonic aciduria (HP:0012120)	1.81195134
86	Recurrent bronchitis (HP:0002837)	1.81143188
87	Hypoplastic iliac wings (HP:0002866)	1.80535521
88	Joint swelling (HP:0001386)	1.76220646
89	Abnormality of vitamin B metabolism (HP:0004340)	1.75904744
90	Tubular atrophy (HP:0000092)	1.75749281
91	Optic nerve hypoplasia (HP:0000609)	1.74745885
92	Clumsiness (HP:0002312)	1.73967144
93	Chronic diarrhea (HP:0002028)	1.73819111
94	Genital tract atresia (HP:0001827)	1.68744634
95	Vaginal atresia (HP:0000148)	1.68708774
96	Stenosis of the external auditory canal (HP:0000402)	1.67449192
97	Large hands (HP:0001176)	1.67127033
98	Ureteral obstruction (HP:0006000)	1.66630419
99	Neoplasm of the colon (HP:0100273)	1.65519575
100	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.63725156

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	8.51203701
2	CASK	4.86683175
3	MET	4.01384068
4	INSRR	3.49278987
5	PDK2	2.94386249
6	CAMK1G	2.68788799
7	PTK2B	2.63275441
8	BMX	2.54697640
9	BCR	2.48540779
10	CSF1R	2.10893886
11	CDK19	2.09941486
12	FGR	1.94597947
13	OXSR1	1.89090035
14	STK38L	1.80294567
15	DAPK2	1.71097910
16	ADRBK2	1.62021063
17	NEK1	1.60689961
18	EIF2AK3	1.52598067
19	PDGFRB	1.50483745
20	WNK4	1.48860057
21	FES	1.46943568
22	PLK2	1.40205860
23	MAP4K2	1.36079631
24	MAP3K6	1.26581146
25	MST1R	1.18376718
26	TAOK3	1.04085048
27	ZAK	0.96589372
28	FRK	0.94404999
29	CCNB1	0.94207508
30	MAPK13	0.93352312
31	GRK1	0.89758939
32	RET	0.89313152
33	CAMK1	0.86954035
34	PLK4	0.82453998
35	ATR	0.76177056
36	FGFR1	0.73907513
37	WNK3	0.73451913
38	TNIK	0.73279273
39	WEE1	0.72836452
40	ARAF	0.69988410
41	GRK7	0.65146849
42	KDR	0.63933046
43	PRKCI	0.63494179
44	BUB1	0.62383280
45	CDK4	0.61573608
46	TXK	0.56881266
47	TLK1	0.56665787
48	EIF2AK1	0.54546329
49	EGFR	0.53262746
50	PIM1	0.52962235
51	CDK8	0.51401032
52	NUAK1	0.50968705
53	PRKCQ	0.49200463
54	EPHA4	0.48622792
55	PLK1	0.47178949
56	LCK	0.46831279
57	TYRO3	0.46358674
58	BCKDK	0.46251749
59	ATM	0.45975331
60	IGF1R	0.45104764
61	ADRBK1	0.43646277
62	UHMK1	0.42518213
63	AURKA	0.41959069
64	SGK1	0.40365010
65	STK38	0.39842297
66	RPS6KB1	0.38377826
67	ROCK1	0.36393670
68	CAMK2A	0.35738493
69	BRAF	0.34362036
70	PRKG1	0.33990516
71	MST4	0.33274214
72	RPS6KA5	0.33268843
73	PASK	0.33064818
74	CDK5	0.31898412
75	PRKCE	0.30690901
76	PINK1	0.30005920
77	MAPKAPK5	0.29538475
78	MAP3K5	0.29424913
79	CHEK1	0.28302256
80	NEK2	0.28218904
81	CDK6	0.27826991
82	MINK1	0.26541175
83	INSR	0.25626658
84	PRKACB	0.25596041
85	CSNK1G2	0.25582673
86	TSSK6	0.25497349
87	ITK	0.25209326
88	STK11	0.24463536
89	PTK2	0.24434549
90	CHEK2	0.23952797
91	WNK1	0.23711752
92	CSNK2A1	0.21456420
93	CDK11A	0.21310643
94	ZAP70	0.19961787
95	PIM2	0.19960543
96	MAPK11	0.19627828
97	NTRK2	0.19283571
98	PRKD3	0.18389857
99	CSNK1E	0.17646184
100	PRKCA	0.17223074

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	3.59131525
2	Protein export_Homo sapiens_hsa03060	3.23090063
3	Primary immunodeficiency_Homo sapiens_hsa05340	3.17071365
4	Mismatch repair_Homo sapiens_hsa03430	2.77308990
5	Homologous recombination_Homo sapiens_hsa03440	2.72990526
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.59666415
7	Regulation of autophagy_Homo sapiens_hsa04140	2.54263806
8	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	2.42910607
9	Proteasome_Homo sapiens_hsa03050	2.34804738
10	Nucleotide excision repair_Homo sapiens_hsa03420	2.34428394
11	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.18844824
12	Parkinsons disease_Homo sapiens_hsa05012	2.07478570
13	Non-homologous end-joining_Homo sapiens_hsa03450	2.07441924
14	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.98870923
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.93120416
16	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.80798618
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.80682706
18	Basal transcription factors_Homo sapiens_hsa03022	1.79886898
19	RNA transport_Homo sapiens_hsa03013	1.60582215
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.54018752
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.49454901
22	Propanoate metabolism_Homo sapiens_hsa00640	1.46871883
23	Renin-angiotensin system_Homo sapiens_hsa04614	1.39855762
24	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.38284417
25	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.34196512
26	RNA degradation_Homo sapiens_hsa03018	1.34163345
27	Oocyte meiosis_Homo sapiens_hsa04114	1.32923227
28	Phototransduction_Homo sapiens_hsa04744	1.31604002
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.31031789
30	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	1.29909767
31	Huntingtons disease_Homo sapiens_hsa05016	1.29724650
32	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.29094228
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.27842771
34	DNA replication_Homo sapiens_hsa03030	1.27288891
35	p53 signaling pathway_Homo sapiens_hsa04115	1.26200858
36	Prion diseases_Homo sapiens_hsa05020	1.23782589
37	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.23094509
38	Alzheimers disease_Homo sapiens_hsa05010	1.20294462
39	Cell cycle_Homo sapiens_hsa04110	1.19875377
40	Ether lipid metabolism_Homo sapiens_hsa00565	1.19737376
41	Caffeine metabolism_Homo sapiens_hsa00232	1.18629695
42	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	1.18604446
43	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.16934244
44	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.10852231
45	Cocaine addiction_Homo sapiens_hsa05030	1.09849681
46	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.08539229
47	Collecting duct acid secretion_Homo sapiens_hsa04966	1.05017051
48	Circadian rhythm_Homo sapiens_hsa04710	0.96605807
49	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.91820875
50	Measles_Homo sapiens_hsa05162	0.87177655
51	ABC transporters_Homo sapiens_hsa02010	0.84515697
52	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.84149129
53	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.83505014
54	RNA polymerase_Homo sapiens_hsa03020	0.81095817
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.79492069
56	African trypanosomiasis_Homo sapiens_hsa05143	0.78542410
57	mRNA surveillance pathway_Homo sapiens_hsa03015	0.74543456
58	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.73819701
59	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.68860151
60	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.68158213
61	Allograft rejection_Homo sapiens_hsa05330	0.64789225
62	Taste transduction_Homo sapiens_hsa04742	0.58025010
63	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.55546104
64	Retinol metabolism_Homo sapiens_hsa00830	0.54575671
65	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.54270210
66	Pyrimidine metabolism_Homo sapiens_hsa00240	0.54118771
67	Folate biosynthesis_Homo sapiens_hsa00790	0.54057022
68	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.51369804
69	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.51099746
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.51099072
71	Cardiac muscle contraction_Homo sapiens_hsa04260	0.49974458
72	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.49492039
73	Peroxisome_Homo sapiens_hsa04146	0.49235358
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.48070502
75	Glutamatergic synapse_Homo sapiens_hsa04724	0.48069700
76	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.47238177
77	Chemokine signaling pathway_Homo sapiens_hsa04062	0.46842977
78	Serotonergic synapse_Homo sapiens_hsa04726	0.46238994
79	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.45772091
80	Circadian entrainment_Homo sapiens_hsa04713	0.44161325
81	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40386705
82	Nicotine addiction_Homo sapiens_hsa05033	0.39363871
83	Legionellosis_Homo sapiens_hsa05134	0.38691578
84	Phenylalanine metabolism_Homo sapiens_hsa00360	0.38271490
85	Tryptophan metabolism_Homo sapiens_hsa00380	0.37043279
86	Salmonella infection_Homo sapiens_hsa05132	0.36878652
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.36352521
88	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.36303100
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33909481
90	Herpes simplex infection_Homo sapiens_hsa05168	0.32449861
91	Olfactory transduction_Homo sapiens_hsa04740	0.32384375
92	Purine metabolism_Homo sapiens_hsa00230	0.31998177
93	Metabolic pathways_Homo sapiens_hsa01100	0.31841079
94	Salivary secretion_Homo sapiens_hsa04970	0.31258638
95	One carbon pool by folate_Homo sapiens_hsa00670	0.31075610
96	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.30754611
97	Amphetamine addiction_Homo sapiens_hsa05031	0.30424056
98	Sulfur relay system_Homo sapiens_hsa04122	0.29992566
99	Chemical carcinogenesis_Homo sapiens_hsa05204	0.29839006
100	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.29511361

RPL7L1P5

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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