ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to gravity (GO:0009629)	6.92204017
2	ovulation cycle (GO:0042698)	4.94910204
3	positive regulation of catecholamine secretion (GO:0033605)	4.82815099
4	DNA deamination (GO:0045006)	4.42878590
5	GDP-mannose metabolic process (GO:0019673)	4.07193114
6	rRNA methylation (GO:0031167)	4.01488212
7	rRNA modification (GO:0000154)	3.89748494
8	negative regulation of membrane potential (GO:0045837)	3.81981110
9	nitric oxide mediated signal transduction (GO:0007263)	3.75961285
10	aldehyde catabolic process (GO:0046185)	3.75401952
11	histone H4-K5 acetylation (GO:0043981)	3.74536980
12	histone H4-K8 acetylation (GO:0043982)	3.74536980
13	parturition (GO:0007567)	3.74302662
14	positive regulation of glycolytic process (GO:0045821)	3.73285131
15	negative regulation of neurological system process (GO:0031645)	3.69202075
16	C4-dicarboxylate transport (GO:0015740)	3.68830157
17	GTP biosynthetic process (GO:0006183)	3.68262444
18	signal peptide processing (GO:0006465)	3.64804763
19	cellular response to dexamethasone stimulus (GO:0071549)	3.61948285
20	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.55008700
21	dopamine transport (GO:0015872)	3.54692562
22	protein heterotetramerization (GO:0051290)	3.54150168
23	xenobiotic catabolic process (GO:0042178)	3.49775044
24	regulation of feeding behavior (GO:0060259)	3.49401509
25	artery smooth muscle contraction (GO:0014824)	3.46923448
26	vascular smooth muscle contraction (GO:0014829)	3.43604742
27	protein import into peroxisome matrix (GO:0016558)	3.39221235
28	tonic smooth muscle contraction (GO:0014820)	3.35804306
29	lactate metabolic process (GO:0006089)	3.32804502
30	response to dexamethasone (GO:0071548)	3.31953639
31	peptidyl-histidine modification (GO:0018202)	3.29671346
32	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.24108254
33	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.24108254
34	skeletal muscle tissue regeneration (GO:0043403)	3.21214467
35	maturation of 5.8S rRNA (GO:0000460)	3.12952027
36	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition	3.11989421
37	regulation of protein glycosylation (GO:0060049)	3.11347508
38	regulation of relaxation of muscle (GO:1901077)	3.09261627
39	cullin deneddylation (GO:0010388)	3.08420463
40	transcytosis (GO:0045056)	3.07875970
41	glycerophospholipid catabolic process (GO:0046475)	3.04417214
42	regulation of oxidative stress-induced neuron death (GO:1903203)	3.03815207
43	regulation of phospholipase A2 activity (GO:0032429)	3.02934459
44	UTP biosynthetic process (GO:0006228)	3.01084019
45	response to nitrosative stress (GO:0051409)	3.00551416
46	negative regulation of gluconeogenesis (GO:0045721)	2.97214753
47	tongue development (GO:0043586)	2.95234029
48	regulation of memory T cell differentiation (GO:0043380)	2.95135258
49	regulation of protein polyubiquitination (GO:1902914)	2.90004330
50	water-soluble vitamin biosynthetic process (GO:0042364)	2.86680033
51	positive regulation of amine transport (GO:0051954)	2.84722062
52	muscle cell cellular homeostasis (GO:0046716)	2.83956712
53	UTP metabolic process (GO:0046051)	2.82250100
54	cardiac left ventricle morphogenesis (GO:0003214)	2.80916765
55	interleukin-6-mediated signaling pathway (GO:0070102)	2.79429397
56	cellular response to leptin stimulus (GO:0044320)	2.79338995
57	tachykinin receptor signaling pathway (GO:0007217)	2.78574920
58	protein neddylation (GO:0045116)	2.76048024
59	histone H4-K16 acetylation (GO:0043984)	2.75872442
60	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.74203729
61	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	2.73280463
62	striated muscle atrophy (GO:0014891)	2.71511702
63	negative regulation of actin filament bundle assembly (GO:0032232)	2.70150113
64	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	2.69640770
65	negative regulation of stress fiber assembly (GO:0051497)	2.67596460
66	positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:00357	2.66893691
67	pseudouridine synthesis (GO:0001522)	2.65514442
68	cellular response to glucocorticoid stimulus (GO:0071385)	2.65226141
69	ubiquinone biosynthetic process (GO:0006744)	2.64974835
70	respiratory chain complex IV assembly (GO:0008535)	2.63822284
71	regulation of cardiac muscle cell contraction (GO:0086004)	2.63763515
72	positive regulation of prostaglandin secretion (GO:0032308)	2.63046922
73	positive regulation of granulocyte differentiation (GO:0030854)	2.61724028
74	positive regulation of smooth muscle contraction (GO:0045987)	2.59949072
75	regulation of cilium movement (GO:0003352)	2.59778713
76	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.58364868
77	preassembly of GPI anchor in ER membrane (GO:0016254)	2.57450526
78	nucleotide-sugar metabolic process (GO:0009225)	2.57252445
79	branched-chain amino acid catabolic process (GO:0009083)	2.56240398
80	protein targeting to peroxisome (GO:0006625)	2.55137011
81	establishment of protein localization to peroxisome (GO:0072663)	2.55137011
82	protein localization to peroxisome (GO:0072662)	2.55137011
83	positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr	2.55090550
84	lateral ventricle development (GO:0021670)	2.54951305
85	nucleotide-sugar biosynthetic process (GO:0009226)	2.53573982
86	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.51873067
87	negative regulation of mast cell activation (GO:0033004)	2.51699933
88	positive regulation of uterine smooth muscle contraction (GO:0070474)	2.51340109
89	regulation of circadian sleep/wake cycle (GO:0042749)	2.51258383
90	regulation of circadian sleep/wake cycle, sleep (GO:0045187)	2.51258383
91	regulation of skeletal muscle contraction (GO:0014819)	2.48693076
92	response to muscle activity (GO:0014850)	2.47564647
93	protein deneddylation (GO:0000338)	2.47012755
94	regulation of cell communication by electrical coupling (GO:0010649)	2.46869251
95	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	2.45783954
96	nucleoside bisphosphate biosynthetic process (GO:0033866)	2.45783954
97	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	2.45783954
98	negative regulation of systemic arterial blood pressure (GO:0003085)	2.45551059
99	cellular response to corticosteroid stimulus (GO:0071384)	2.45167081
100	neurotransmitter uptake (GO:0001504)	2.44900337

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.64410880
2	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.60942612
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.38555838
4	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.35113655
5	VDR_22108803_ChIP-Seq_LS180_Human	2.96841062
6	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.56824606
7	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.50870490
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.40354682
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.18640045
10	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.14075699
11	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.14040713
12	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.13437435
13	FUS_26573619_Chip-Seq_HEK293_Human	2.05769664
14	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.98577227
15	ER_23166858_ChIP-Seq_MCF-7_Human	1.82364062
16	BCAT_22108803_ChIP-Seq_LS180_Human	1.80739435
17	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.76339491
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.75813415
19	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.69666883
20	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.69618321
21	P300_19829295_ChIP-Seq_ESCs_Human	1.65769286
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64545741
23	EWS_26573619_Chip-Seq_HEK293_Human	1.61960205
24	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59867622
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.57489842
26	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.55246885
27	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.54479882
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.54474647
29	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.52461870
30	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.51521288
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.51237360
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.50939997
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.48662943
34	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48576881
35	CDX2_22108803_ChIP-Seq_LS180_Human	1.44640848
36	CBP_20019798_ChIP-Seq_JUKART_Human	1.43698755
37	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.43698755
38	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.43655360
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37765470
40	ELK1_19687146_ChIP-ChIP_HELA_Human	1.34697414
41	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32882382
42	STAT3_23295773_ChIP-Seq_U87_Human	1.31809095
43	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.31182565
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.31182565
45	TCF4_23295773_ChIP-Seq_U87_Human	1.30892902
46	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.29051232
47	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28490673
48	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25253646
49	VDR_23849224_ChIP-Seq_CD4+_Human	1.24845603
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.23024874
51	TCF4_22108803_ChIP-Seq_LS180_Human	1.22181325
52	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22145342
53	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19463408
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.19296319
55	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.18726719
56	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.18319129
57	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.17846949
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.16020768
59	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14491035
60	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14445811
61	AR_25329375_ChIP-Seq_VCAP_Human	1.13544834
62	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13072843
63	P53_22387025_ChIP-Seq_ESCs_Mouse	1.11709679
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.11302246
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.11302246
66	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.10738684
67	AR_20517297_ChIP-Seq_VCAP_Human	1.10460600
68	TP53_22573176_ChIP-Seq_HFKS_Human	1.09869037
69	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.09639549
70	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.07752530
71	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.07637771
72	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.07569737
73	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.06905736
74	MYC_19829295_ChIP-Seq_ESCs_Human	1.06762699
75	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.06741969
76	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.06173181
77	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.05744006
78	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.05171320
79	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.03946524
80	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.03659744
81	P300_18555785_Chip-Seq_ESCs_Mouse	1.02558931
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.01967177
83	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.01209239
84	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.00897898
85	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.00399028
86	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.99960363
87	RUNX1_17652178_ChIP-ChIP_JURKAT_Human	0.99861781
88	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.99726763
89	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.99570858
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.99189981
91	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	0.99134452
92	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.98138437
93	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.97597318
94	RUNX2_22187159_ChIP-Seq_PCA_Human	0.97154480
95	E2F1_18555785_Chip-Seq_ESCs_Mouse	0.96872104
96	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.95981609
97	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.95611992
98	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.94859290
99	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93727812
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.93024417

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	4.17641247
2	MP0003880_abnormal_central_pattern	3.91043501
3	MP0009379_abnormal_foot_pigmentation	3.44700476
4	MP0001501_abnormal_sleep_pattern	3.19126036
5	MP0001986_abnormal_taste_sensitivity	3.18495388
6	MP0000372_irregular_coat_pigmentation	2.85735783
7	MP0006072_abnormal_retinal_apoptosis	2.38551415
8	MP0009780_abnormal_chondrocyte_physiolo	2.37127640
9	MP0006054_spinal_hemorrhage	2.34178619
10	MP0008775_abnormal_heart_ventricle	2.23975003
11	MP0004215_abnormal_myocardial_fiber	2.19413027
12	MP0000749_muscle_degeneration	2.13192253
13	MP0000538_abnormal_urinary_bladder	2.11157607
14	MP0003950_abnormal_plasma_membrane	1.99730834
15	MP0006276_abnormal_autonomic_nervous	1.98980890
16	MP0004142_abnormal_muscle_tone	1.96184984
17	MP0000013_abnormal_adipose_tissue	1.93064706
18	MP0000383_abnormal_hair_follicle	1.84662011
19	MP0005423_abnormal_somatic_nervous	1.78496619
20	MP0005367_renal/urinary_system_phenotyp	1.72736567
21	MP0000516_abnormal_urinary_system	1.72736567
22	MP0002736_abnormal_nociception_after	1.72118305
23	MP0000569_abnormal_digit_pigmentation	1.71394862
24	MP0004084_abnormal_cardiac_muscle	1.70728103
25	MP0005253_abnormal_eye_physiology	1.66910202
26	MP0008872_abnormal_physiological_respon	1.57370138
27	MP0003718_maternal_effect	1.56096604
28	MP0002332_abnormal_exercise_endurance	1.55363953
29	MP0009053_abnormal_anal_canal	1.53570618
30	MP0005551_abnormal_eye_electrophysiolog	1.53282088
31	MP0002163_abnormal_gland_morphology	1.50380382
32	MP0001440_abnormal_grooming_behavior	1.49895004
33	MP0005448_abnormal_energy_balance	1.44848412
34	MP0003011_delayed_dark_adaptation	1.42999531
35	MP0005220_abnormal_exocrine_pancreas	1.41425008
36	MP0002837_dystrophic_cardiac_calcinosis	1.40650792
37	MP0005379_endocrine/exocrine_gland_phen	1.35226688
38	MP0000230_abnormal_systemic_arterial	1.34820871
39	MP0001968_abnormal_touch/_nociception	1.34404986
40	MP0004133_heterotaxia	1.32693933
41	MP0004233_abnormal_muscle_weight	1.29500397
42	MP0004484_altered_response_of	1.28457577
43	MP0002971_abnormal_brown_adipose	1.27784628
44	MP0005332_abnormal_amino_acid	1.25153539
45	MP0000747_muscle_weakness	1.22580918
46	MP0005360_urolithiasis	1.22130108
47	MP0004043_abnormal_pH_regulation	1.20269461
48	MP0004782_abnormal_surfactant_physiolog	1.20129824
49	MP0002108_abnormal_muscle_morphology	1.12536398
50	MP0001764_abnormal_homeostasis	1.11490962
51	MP0010678_abnormal_skin_adnexa	1.10922378
52	MP0010386_abnormal_urinary_bladder	1.10189427
53	MP0005084_abnormal_gallbladder_morpholo	1.07806433
54	MP0003646_muscle_fatigue	1.05415059
55	MP0004270_analgesia	1.05366080
56	MP0002653_abnormal_ependyma_morphology	1.04433349
57	MP0001944_abnormal_pancreas_morphology	1.03253740
58	MP0004085_abnormal_heartbeat	1.01912774
59	MP0009384_cardiac_valve_regurgitation	1.01767139
60	MP0002269_muscular_atrophy	0.99956345
61	MP0003137_abnormal_impulse_conducting	0.97854163
62	MP0005645_abnormal_hypothalamus_physiol	0.94737427
63	MP0009115_abnormal_fat_cell	0.93263627
64	MP0003633_abnormal_nervous_system	0.90500270
65	MP0003436_decreased_susceptibility_to	0.89886310
66	MP0005595_abnormal_vascular_smooth	0.89276372
67	MP0003122_maternal_imprinting	0.88181168
68	MP0002557_abnormal_social/conspecific_i	0.87342199
69	MP0005334_abnormal_fat_pad	0.86023322
70	MP0009745_abnormal_behavioral_response	0.84880161
71	MP0000427_abnormal_hair_cycle	0.83610090
72	MP0009250_abnormal_appendicular_skeleto	0.82630921
73	MP0002254_reproductive_system_inflammat	0.82472562
74	MP0003191_abnormal_cellular_cholesterol	0.82050561
75	MP0010368_abnormal_lymphatic_system	0.81937300
76	MP0001664_abnormal_digestion	0.81901908
77	MP0008875_abnormal_xenobiotic_pharmacok	0.81428991
78	MP0000750_abnormal_muscle_regeneration	0.80976287
79	MP0006036_abnormal_mitochondrial_physio	0.80481425
80	MP0004036_abnormal_muscle_relaxation	0.78494871
81	MP0005075_abnormal_melanosome_morpholog	0.78259676
82	MP0002693_abnormal_pancreas_physiology	0.78114365
83	MP0002234_abnormal_pharynx_morphology	0.77779298
84	MP0002106_abnormal_muscle_physiology	0.77504437
85	MP0002928_abnormal_bile_duct	0.77336044
86	MP0002277_abnormal_respiratory_mucosa	0.76192256
87	MP0002184_abnormal_innervation	0.76177589
88	MP0005451_abnormal_body_composition	0.75996824
89	MP0001177_atelectasis	0.74374855
90	MP0008058_abnormal_DNA_repair	0.74304558
91	MP0000579_abnormal_nail_morphology	0.73957098
92	MP0003866_abnormal_defecation	0.73385216
93	MP0001661_extended_life_span	0.72758862
94	MP0005452_abnormal_adipose_tissue	0.71752616
95	MP0005395_other_phenotype	0.71530369
96	MP0002132_abnormal_respiratory_system	0.71529727
97	MP0001853_heart_inflammation	0.71492008
98	MP0005369_muscle_phenotype	0.70888192
99	MP0005165_increased_susceptibility_to	0.66185257
100	MP0004883_abnormal_blood_vessel	0.65188380

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 2 muscle fiber atrophy (HP:0003554)	6.04239257
2	Muscle fiber atrophy (HP:0100295)	5.13330004
3	Weak cry (HP:0001612)	4.14105587
4	Fatigable weakness (HP:0003473)	4.03733271
5	Abnormality of the neuromuscular junction (HP:0003398)	4.03733271
6	Decreased muscle mass (HP:0003199)	3.54451070
7	Pancreatic fibrosis (HP:0100732)	3.23290778
8	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.17792645
9	Molar tooth sign on MRI (HP:0002419)	3.11087650
10	Abnormality of midbrain morphology (HP:0002418)	3.11087650
11	Ketoacidosis (HP:0001993)	2.99280975
12	True hermaphroditism (HP:0010459)	2.90366857
13	Atonic seizures (HP:0010819)	2.87433259
14	Pancreatic cysts (HP:0001737)	2.86844339
15	Abnormality of placental membranes (HP:0011409)	2.84635580
16	Amniotic constriction ring (HP:0009775)	2.84635580
17	Fibular aplasia (HP:0002990)	2.78666108
18	Hemiparesis (HP:0001269)	2.77099181
19	Acute necrotizing encephalopathy (HP:0006965)	2.74952270
20	Sensory axonal neuropathy (HP:0003390)	2.74754418
21	Hyperlipoproteinemia (HP:0010980)	2.73427672
22	Popliteal pterygium (HP:0009756)	2.68663707
23	Hypoglycemic seizures (HP:0002173)	2.66565746
24	Anencephaly (HP:0002323)	2.63802792
25	Type I transferrin isoform profile (HP:0003642)	2.61885893
26	Nonprogressive disorder (HP:0003680)	2.61264162
27	Abnormal hair whorl (HP:0010721)	2.61002401
28	Intestinal atresia (HP:0011100)	2.59746171
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.59724332
30	Pendular nystagmus (HP:0012043)	2.59473921
31	Ependymoma (HP:0002888)	2.56329807
32	Progressive macrocephaly (HP:0004481)	2.55922568
33	Abnormality of alanine metabolism (HP:0010916)	2.49318147
34	Hyperalaninemia (HP:0003348)	2.49318147
35	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.49318147
36	Nephronophthisis (HP:0000090)	2.47832157
37	Easy fatigability (HP:0003388)	2.44238802
38	Acute encephalopathy (HP:0006846)	2.42319645
39	Hypothermia (HP:0002045)	2.40605865
40	Abolished electroretinogram (ERG) (HP:0000550)	2.38561295
41	Cutaneous melanoma (HP:0012056)	2.37604840
42	Methylmalonic acidemia (HP:0002912)	2.37538143
43	Wrist flexion contracture (HP:0001239)	2.36614153
44	Abnormal mitochondria in muscle tissue (HP:0008316)	2.35666414
45	Tetraparesis (HP:0002273)	2.34823006
46	Abnormal biliary tract physiology (HP:0012439)	2.34432102
47	Bile duct proliferation (HP:0001408)	2.34432102
48	Increased CSF lactate (HP:0002490)	2.33234498
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.32876787
50	Mitochondrial inheritance (HP:0001427)	2.25298306
51	Ketosis (HP:0001946)	2.23688608
52	Hepatocellular necrosis (HP:0001404)	2.22661881
53	Methylmalonic aciduria (HP:0012120)	2.20370277
54	Fetal akinesia sequence (HP:0001989)	2.17422956
55	Delayed CNS myelination (HP:0002188)	2.16002592
56	Hyperglycemia (HP:0003074)	2.12536213
57	Tongue fasciculations (HP:0001308)	2.11499528
58	Postural tremor (HP:0002174)	2.09820224
59	Hyperinsulinemic hypoglycemia (HP:0000825)	2.09517187
60	Hypoplastic ischia (HP:0003175)	2.09474088
61	Fair hair (HP:0002286)	2.09010932
62	Abnormality of the renal medulla (HP:0100957)	2.08125624
63	Disinhibition (HP:0000734)	2.06328296
64	Hypoglycemic coma (HP:0001325)	2.05299145
65	Increased corneal curvature (HP:0100692)	2.04467032
66	Keratoconus (HP:0000563)	2.04467032
67	Hypomagnesemia (HP:0002917)	2.03203212
68	Hyperventilation (HP:0002883)	2.01982604
69	Hepatic necrosis (HP:0002605)	1.99882803
70	Glucose intolerance (HP:0000833)	1.99852424
71	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99041512
72	Abnormal protein N-linked glycosylation (HP:0012347)	1.99041512
73	Abnormal protein glycosylation (HP:0012346)	1.99041512
74	Abnormal glycosylation (HP:0012345)	1.99041512
75	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.96847012
76	Abnormal rod and cone electroretinograms (HP:0008323)	1.96114009
77	Cerebral edema (HP:0002181)	1.94076486
78	Pigmentary retinal degeneration (HP:0001146)	1.92900269
79	Abnormal delayed hypersensitivity skin test (HP:0002963)	1.92557607
80	Absent phalangeal crease (HP:0006109)	1.89931942
81	Respiratory failure (HP:0002878)	1.88978285
82	Gowers sign (HP:0003391)	1.86782739
83	Neoplasm of the heart (HP:0100544)	1.86199984
84	Agitation (HP:0000713)	1.85446706
85	Hypoplasia of the uterus (HP:0000013)	1.84668174
86	Cystic liver disease (HP:0006706)	1.84351586
87	Abnormal drinking behavior (HP:0030082)	1.84107243
88	Polydipsia (HP:0001959)	1.84107243
89	Occipital encephalocele (HP:0002085)	1.81422084
90	Reduced antithrombin III activity (HP:0001976)	1.81297066
91	Brushfield spots (HP:0001088)	1.81087896
92	Absent/shortened dynein arms (HP:0200106)	1.79317074
93	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.79317074
94	Oral leukoplakia (HP:0002745)	1.79080589
95	Abnormality of the pupil (HP:0000615)	1.78587350
96	Dyschromatopsia (HP:0007641)	1.77903066
97	Late onset (HP:0003584)	1.77548136
98	Abnormality of vitamin B metabolism (HP:0004340)	1.77141222
99	Attenuation of retinal blood vessels (HP:0007843)	1.76035617
100	Chorioretinal atrophy (HP:0000533)	1.75441867

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MUSK	9.50321594
2	MST4	4.43477586
3	FRK	3.69943590
4	ERBB4	2.96530873
5	TAOK3	2.84386715
6	CAMKK2	2.36800080
7	STK39	2.21250194
8	MYLK	2.06606628
9	MAP3K12	2.03487625
10	PIK3CA	1.93301063
11	WNK4	1.81971969
12	PIK3CG	1.57967703
13	MARK3	1.53200087
14	BMPR1B	1.53028827
15	PLK2	1.50120216
16	MAP3K4	1.47987452
17	ZAK	1.43464877
18	OXSR1	1.32338179
19	TLK1	1.29245623
20	PKN1	1.25858767
21	MAP2K7	1.24997540
22	PINK1	1.20703811
23	PAK3	1.17342149
24	SIK3	1.15864492
25	PBK	1.09170362
26	MAP4K2	1.08258583
27	NUAK1	1.07706556
28	EPHA3	0.97742421
29	BUB1	0.94168705
30	TRPM7	0.92285567
31	ADRBK2	0.91376881
32	BMPR2	0.88391504
33	ERBB3	0.88125814
34	TNIK	0.87216089
35	MAP3K6	0.85315367
36	EIF2AK3	0.82643012
37	GRK1	0.80072790
38	ALK	0.79514653
39	TXK	0.76935765
40	NLK	0.75596927
41	NME1	0.72429706
42	PDK2	0.68856847
43	MAP3K5	0.68760290
44	OBSCN	0.67469133
45	DAPK2	0.67170454
46	MAP2K6	0.65381822
47	LIMK1	0.64977291
48	MAP3K9	0.64333640
49	CAMK1	0.64309124
50	LMTK2	0.63927190
51	TGFBR2	0.62884303
52	TAF1	0.62522133
53	PNCK	0.62243936
54	GRK7	0.60732332
55	CAMK4	0.60272845
56	MAPK11	0.58424578
57	CAMK2A	0.55818303
58	PRKCE	0.55219073
59	ADRBK1	0.54140589
60	ERBB2	0.53976091
61	MAPK13	0.53767595
62	EPHB1	0.53459738
63	MARK1	0.53142643
64	PLK3	0.51104355
65	INSRR	0.50326829
66	BRSK2	0.49035433
67	PHKG1	0.45823731
68	PHKG2	0.45823731
69	JAK1	0.45590090
70	FER	0.43865186
71	ABL1	0.43469289
72	JAK2	0.43118307
73	SCYL2	0.41679462
74	KSR1	0.41517328
75	GRK5	0.40660952
76	PTK2B	0.40223684
77	IKBKB	0.39183732
78	TRIM28	0.38871525
79	AKT2	0.38214273
80	ROCK1	0.36074280
81	CAMK2G	0.34748375
82	WNK3	0.33255725
83	BCKDK	0.33224522
84	PIM1	0.30226695
85	DYRK2	0.28800112
86	GSK3A	0.28475044
87	PRKACB	0.27053830
88	BLK	0.26750120
89	ROCK2	0.26565530
90	PRKACA	0.25209355
91	WNK1	0.23778688
92	MAPK15	0.23311741
93	DAPK3	0.22252358
94	PAK6	0.22160398
95	CCNB1	0.21494968
96	TGFBR1	0.20837106
97	CAMK2D	0.20781214
98	SGK2	0.20118096
99	ATM	0.19063353
100	RPS6KA4	0.18996836

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Protein export_Homo sapiens_hsa03060	2.83465802
2	RNA polymerase_Homo sapiens_hsa03020	2.83189421
3	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.76238036
4	Collecting duct acid secretion_Homo sapiens_hsa04966	2.74615275
5	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.70147302
6	Selenocompound metabolism_Homo sapiens_hsa00450	2.67293127
7	One carbon pool by folate_Homo sapiens_hsa00670	2.33491861
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21627516
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.12507739
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.08705071
11	Propanoate metabolism_Homo sapiens_hsa00640	2.00832322
12	Proteasome_Homo sapiens_hsa03050	1.99937129
13	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.90358237
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.90086117
15	Peroxisome_Homo sapiens_hsa04146	1.89337872
16	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.87893740
17	Sulfur metabolism_Homo sapiens_hsa00920	1.86766443
18	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.82916051
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.75319598
20	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.73982842
21	Regulation of autophagy_Homo sapiens_hsa04140	1.67800493
22	Butanoate metabolism_Homo sapiens_hsa00650	1.64171313
23	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.63077885
24	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.60268219
25	Parkinsons disease_Homo sapiens_hsa05012	1.59264580
26	Fatty acid degradation_Homo sapiens_hsa00071	1.58120510
27	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.57683528
28	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.44089642
29	Type I diabetes mellitus_Homo sapiens_hsa04940	1.42158541
30	Asthma_Homo sapiens_hsa05310	1.26801797
31	RNA degradation_Homo sapiens_hsa03018	1.26630551
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.24737620
33	Fatty acid elongation_Homo sapiens_hsa00062	1.15031062
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.13353041
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.13093938
36	Fatty acid metabolism_Homo sapiens_hsa01212	1.07343147
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.07197262
38	Allograft rejection_Homo sapiens_hsa05330	1.02121435
39	Tryptophan metabolism_Homo sapiens_hsa00380	0.98005182
40	Phototransduction_Homo sapiens_hsa04744	0.97392450
41	Glutathione metabolism_Homo sapiens_hsa00480	0.97276049
42	Alzheimers disease_Homo sapiens_hsa05010	0.93341249
43	ABC transporters_Homo sapiens_hsa02010	0.93112140
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.92516623
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92211298
46	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.90215400
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.87059252
48	Pyrimidine metabolism_Homo sapiens_hsa00240	0.85935236
49	Huntingtons disease_Homo sapiens_hsa05016	0.85717300
50	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84166769
51	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.83516896
52	Non-homologous end-joining_Homo sapiens_hsa03450	0.82937070
53	Renin-angiotensin system_Homo sapiens_hsa04614	0.82895222
54	Olfactory transduction_Homo sapiens_hsa04740	0.78844115
55	Rheumatoid arthritis_Homo sapiens_hsa05323	0.78667196
56	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.78637356
57	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.75274331
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.75189641
59	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.72610277
60	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71717379
61	Arginine and proline metabolism_Homo sapiens_hsa00330	0.71107281
62	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.69876322
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.69540841
64	Vibrio cholerae infection_Homo sapiens_hsa05110	0.69285767
65	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.69057622
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.65831690
67	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.64761940
68	Metabolic pathways_Homo sapiens_hsa01100	0.64691477
69	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.64602081
70	Homologous recombination_Homo sapiens_hsa03440	0.64587359
71	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.63986238
72	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.61556771
73	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.60974245
74	Chemical carcinogenesis_Homo sapiens_hsa05204	0.58636637
75	Taste transduction_Homo sapiens_hsa04742	0.54986418
76	Amphetamine addiction_Homo sapiens_hsa05031	0.54438443
77	Caffeine metabolism_Homo sapiens_hsa00232	0.54372533
78	Mineral absorption_Homo sapiens_hsa04978	0.53387966
79	Retinol metabolism_Homo sapiens_hsa00830	0.52759037
80	Galactose metabolism_Homo sapiens_hsa00052	0.52121091
81	Graft-versus-host disease_Homo sapiens_hsa05332	0.51383471
82	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51171818
83	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.51171297
84	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50862611
85	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.50602959
86	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.48976497
87	Purine metabolism_Homo sapiens_hsa00230	0.46318079
88	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.46068283
89	Long-term depression_Homo sapiens_hsa04730	0.45852690
90	Serotonergic synapse_Homo sapiens_hsa04726	0.45725934
91	Primary immunodeficiency_Homo sapiens_hsa05340	0.40804488
92	Insulin secretion_Homo sapiens_hsa04911	0.36707668
93	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.35701612
94	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.35161604
95	Cardiac muscle contraction_Homo sapiens_hsa04260	0.33763455
96	Basal transcription factors_Homo sapiens_hsa03022	0.33387501
97	Salivary secretion_Homo sapiens_hsa04970	0.31356932
98	Cocaine addiction_Homo sapiens_hsa05030	0.29660162
99	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.29500045
100	Salmonella infection_Homo sapiens_hsa05132	0.29335889

RPL7L1P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »