RPL7P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.16095728
2cytidine deamination (GO:0009972)5.99817695
3cytidine metabolic process (GO:0046087)5.99817695
4cytidine catabolic process (GO:0006216)5.99817695
5ribosomal small subunit assembly (GO:0000028)5.93069621
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.70597623
7pyrimidine ribonucleoside catabolic process (GO:0046133)5.19043686
8viral transcription (GO:0019083)3.97878698
9energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89550317
10ATP synthesis coupled proton transport (GO:0015986)3.89550317
11mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.85642042
12translational termination (GO:0006415)3.83019171
13ribosomal large subunit biogenesis (GO:0042273)3.72446235
14translational elongation (GO:0006414)3.65979670
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55980382
16maturation of SSU-rRNA (GO:0030490)3.52051138
17cotranslational protein targeting to membrane (GO:0006613)3.47987293
18protein targeting to ER (GO:0045047)3.47517468
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40444126
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.38822919
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.38822919
22positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.37823402
23response to pheromone (GO:0019236)3.35414604
24protein localization to endoplasmic reticulum (GO:0070972)3.31626959
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.29090816
26Arp2/3 complex-mediated actin nucleation (GO:0034314)3.28733977
27positive T cell selection (GO:0043368)3.26214394
28positive thymic T cell selection (GO:0045059)3.25512641
29pseudouridine synthesis (GO:0001522)3.18293994
30negative T cell selection (GO:0043383)3.17303909
31ribosomal small subunit biogenesis (GO:0042274)3.12444439
32positive regulation of defense response to virus by host (GO:0002230)3.11315325
33actin nucleation (GO:0045010)3.11287424
34protein complex biogenesis (GO:0070271)3.10596321
35piRNA metabolic process (GO:0034587)3.08636531
36positive regulation of alpha-beta T cell proliferation (GO:0046641)3.02635743
37protein neddylation (GO:0045116)3.02563259
38electron transport chain (GO:0022900)3.01417642
39respiratory electron transport chain (GO:0022904)3.00633841
40regulation of cellular amino acid metabolic process (GO:0006521)2.98445769
41pyrimidine nucleoside catabolic process (GO:0046135)2.92714903
42translational initiation (GO:0006413)2.92087902
43regulation of regulatory T cell differentiation (GO:0045589)2.91175504
44proteasome assembly (GO:0043248)2.90823831
45viral life cycle (GO:0019058)2.89671942
46DNA demethylation (GO:0080111)2.87679345
47translation (GO:0006412)2.86466504
48negative regulation of T cell apoptotic process (GO:0070233)2.85955191
49positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84979459
50DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84658293
51termination of RNA polymerase III transcription (GO:0006386)2.84506653
52transcription elongation from RNA polymerase III promoter (GO:0006385)2.84506653
53nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83001795
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82266944
55negative regulation by host of viral transcription (GO:0043922)2.82207105
56mitochondrial respiratory chain complex assembly (GO:0033108)2.81150763
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.79986290
58water-soluble vitamin biosynthetic process (GO:0042364)2.79934940
59metallo-sulfur cluster assembly (GO:0031163)2.79636989
60iron-sulfur cluster assembly (GO:0016226)2.79636989
61cellular protein complex disassembly (GO:0043624)2.78002750
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76728701
63mitochondrial respiratory chain complex I assembly (GO:0032981)2.76728701
64NADH dehydrogenase complex assembly (GO:0010257)2.76728701
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.75656391
66negative regulation of mast cell activation (GO:0033004)2.75318978
67signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.74137794
68signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.74137794
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.74137794
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.73297169
71positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.72885451
72intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.72497010
73signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.72497010
74positive regulation of B cell differentiation (GO:0045579)2.71465050
75negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.71054855
76positive regulation of calcium-mediated signaling (GO:0050850)2.70300217
77base-excision repair, AP site formation (GO:0006285)2.68550006
78response to interferon-beta (GO:0035456)2.67554932
79positive regulation of natural killer cell mediated immunity (GO:0002717)2.67223916
80DNA dealkylation (GO:0035510)2.66583201
81nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.66457397
82platelet dense granule organization (GO:0060155)2.65879572
83positive regulation of prostaglandin secretion (GO:0032308)2.65341330
84axoneme assembly (GO:0035082)2.65212062
85rRNA modification (GO:0000154)2.64336921
86regulation of alpha-beta T cell proliferation (GO:0046640)2.63314227
87regulation of T cell receptor signaling pathway (GO:0050856)2.62081363
88establishment of protein localization to mitochondrial membrane (GO:0090151)2.59668223
89negative thymic T cell selection (GO:0045060)2.58745578
90positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.57654872
91positive regulation of interleukin-8 secretion (GO:2000484)2.56232708
92signal transduction involved in DNA damage checkpoint (GO:0072422)2.55878377
93signal transduction involved in DNA integrity checkpoint (GO:0072401)2.55878377
94respiratory chain complex IV assembly (GO:0008535)2.55016880
95regulation of chronic inflammatory response (GO:0002676)2.54536378
96regulation of interleukin-8 secretion (GO:2000482)2.53962079
97cellular component biogenesis (GO:0044085)2.53839590
98parturition (GO:0007567)2.52113326
99signal transduction involved in cell cycle checkpoint (GO:0072395)2.52055637
100cytochrome complex assembly (GO:0017004)2.52015176

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.76720608
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.67341070
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.45709136
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.31039825
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.21993655
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.21457463
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.05853369
8VDR_22108803_ChIP-Seq_LS180_Human2.90734906
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88929121
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.77780881
11ZNF274_21170338_ChIP-Seq_K562_Hela2.64670581
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64474553
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52674777
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49561273
15VDR_23849224_ChIP-Seq_CD4+_Human2.47950813
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.37409737
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.28488101
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.17650874
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17356042
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.06679461
21FOXP3_21729870_ChIP-Seq_TREG_Human1.95763030
22ELK1_19687146_ChIP-ChIP_HELA_Human1.93996652
23NOTCH1_21737748_ChIP-Seq_TLL_Human1.90005703
24IGF1R_20145208_ChIP-Seq_DFB_Human1.87679878
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.77375121
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.75912652
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74689467
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.72885702
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67363097
30MYC_18940864_ChIP-ChIP_HL60_Human1.67136986
31EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65393998
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.62961403
33EWS_26573619_Chip-Seq_HEK293_Human1.62382853
34MYB_26560356_Chip-Seq_TH2_Human1.61408466
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59485960
36IRF8_21731497_ChIP-ChIP_J774_Mouse1.56598261
37GATA3_26560356_Chip-Seq_TH2_Human1.51633733
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48968809
39TP53_22573176_ChIP-Seq_HFKS_Human1.44950396
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.42651096
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.42651096
42AR_20517297_ChIP-Seq_VCAP_Human1.41718437
43FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41049146
44PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32031159
45ER_23166858_ChIP-Seq_MCF-7_Human1.31149120
46FUS_26573619_Chip-Seq_HEK293_Human1.31096155
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.27933586
48AUTS2_25519132_ChIP-Seq_293T-REX_Human1.26789579
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.22312504
50RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.21889566
51GATA3_27048872_Chip-Seq_THYMUS_Human1.21489589
52PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.21185880
53NCOR_22424771_ChIP-Seq_293T_Human1.20717299
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20463632
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.20196797
56EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.20138125
57NANOG_20526341_ChIP-Seq_ESCs_Human1.20109312
58TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20074691
59SOX2_19829295_ChIP-Seq_ESCs_Human1.20004373
60NANOG_19829295_ChIP-Seq_ESCs_Human1.20004373
61IRF1_19129219_ChIP-ChIP_H3396_Human1.19745335
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19342361
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.18780837
64GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16205816
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15330263
66SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.14470480
67STAT6_21828071_ChIP-Seq_BEAS2B_Human1.13353423
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12766289
69CBP_20019798_ChIP-Seq_JUKART_Human1.12766289
70FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10162332
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.10002620
72PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.09971464
73RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09896784
74MYC_18358816_ChIP-ChIP_MESCs_Mouse1.08178287
75HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07499147
76RUNX_20019798_ChIP-Seq_JUKART_Human1.07277171
77TAF2_19829295_ChIP-Seq_ESCs_Human1.06568468
78FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06259148
79HOXB7_26014856_ChIP-Seq_BT474_Human1.06172163
80ERG_20517297_ChIP-Seq_VCAP_Human1.05639146
81EZH2_22144423_ChIP-Seq_EOC_Human1.03263192
82FOXH1_21741376_ChIP-Seq_EPCs_Human1.03198007
83MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02417051
84ERA_21632823_ChIP-Seq_H3396_Human1.00075517
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99657715
86NFE2_27457419_Chip-Seq_LIVER_Mouse0.99314701
87MYC_19829295_ChIP-Seq_ESCs_Human0.98906843
88ZFP57_27257070_Chip-Seq_ESCs_Mouse0.98652374
89CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97614755
90BCAT_22108803_ChIP-Seq_LS180_Human0.96968476
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.96735780
92P300_19829295_ChIP-Seq_ESCs_Human0.95977190
93FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.95527009
94CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95410742
95BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94944424
96BCL6_27268052_Chip-Seq_Bcells_Human0.93954220
97ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93766183
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.93544736
99EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93258065
100CIITA_25753668_ChIP-Seq_RAJI_Human0.92595730

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.49414405
2MP0002138_abnormal_hepatobiliary_system3.15434010
3MP0001835_abnormal_antigen_presentation3.09364379
4MP0009379_abnormal_foot_pigmentation2.78037594
5MP0009785_altered_susceptibility_to2.40254016
6MP0002102_abnormal_ear_morphology2.40184597
7MP0009333_abnormal_splenocyte_physiolog2.38069346
8MP0003763_abnormal_thymus_physiology2.33389987
9MP0002148_abnormal_hypersensitivity_rea2.31025123
10MP0006292_abnormal_olfactory_placode2.29106313
11MP0000372_irregular_coat_pigmentation2.21909673
12MP0008877_abnormal_DNA_methylation2.12808009
13MP0008872_abnormal_physiological_respon2.10776983
14MP0001873_stomach_inflammation2.06229045
15MP0002166_altered_tumor_susceptibility2.02538855
16MP0000685_abnormal_immune_system2.02398974
17MP0001800_abnormal_humoral_immune1.95070265
18MP0003806_abnormal_nucleotide_metabolis1.93188682
19MP0008875_abnormal_xenobiotic_pharmacok1.90700801
20MP0004145_abnormal_muscle_electrophysio1.81486143
21MP0002006_tumorigenesis1.81334942
22MP0005000_abnormal_immune_tolerance1.80755440
23MP0005645_abnormal_hypothalamus_physiol1.79539596
24MP0004147_increased_porphyrin_level1.76240896
25MP0006072_abnormal_retinal_apoptosis1.70142894
26MP0002723_abnormal_immune_serum1.62978785
27MP0003646_muscle_fatigue1.61612209
28MP0001790_abnormal_immune_system1.61140505
29MP0005387_immune_system_phenotype1.61140505
30MP0002420_abnormal_adaptive_immunity1.58584516
31MP0005075_abnormal_melanosome_morpholog1.57145352
32MP0001819_abnormal_immune_cell1.54727184
33MP0005084_abnormal_gallbladder_morpholo1.50136846
34MP0005646_abnormal_pituitary_gland1.50018045
35MP0002876_abnormal_thyroid_physiology1.49783091
36MP0005551_abnormal_eye_electrophysiolog1.49615978
37MP0003866_abnormal_defecation1.48331739
38MP0002837_dystrophic_cardiac_calcinosis1.42942227
39MP0002452_abnormal_antigen_presenting1.39884508
40MP0001968_abnormal_touch/_nociception1.37871019
41MP0005389_reproductive_system_phenotype1.37161379
42MP0002398_abnormal_bone_marrow1.34561973
43MP0005025_abnormal_response_to1.31001718
44MP0001986_abnormal_taste_sensitivity1.29509128
45MP0002160_abnormal_reproductive_system1.28800190
46MP0001764_abnormal_homeostasis1.27778601
47MP0000716_abnormal_immune_system1.24188685
48MP0010155_abnormal_intestine_physiology1.24173440
49MP0003786_premature_aging1.23988687
50MP0002163_abnormal_gland_morphology1.23155430
51MP0002405_respiratory_system_inflammati1.19958858
52MP0004885_abnormal_endolymph1.19529857
53MP0000689_abnormal_spleen_morphology1.18791455
54MP0001485_abnormal_pinna_reflex1.16906472
55MP0001905_abnormal_dopamine_level1.16848549
56MP0008058_abnormal_DNA_repair1.14510750
57MP0003878_abnormal_ear_physiology1.13298462
58MP0005377_hearing/vestibular/ear_phenot1.13298462
59MP0001919_abnormal_reproductive_system1.12617109
60MP0002736_abnormal_nociception_after1.12486575
61MP0006036_abnormal_mitochondrial_physio1.09939461
62MP0002234_abnormal_pharynx_morphology1.08457006
63MP0003567_abnormal_fetal_cardiomyocyte1.08368083
64MP0005410_abnormal_fertilization1.04650571
65MP0006082_CNS_inflammation1.04489743
66MP0008995_early_reproductive_senescence1.03849796
67MP0000703_abnormal_thymus_morphology1.01795152
68MP0002933_joint_inflammation1.01714048
69MP0002722_abnormal_immune_system1.01633092
70MP0005636_abnormal_mineral_homeostasis1.00846008
71MP0001845_abnormal_inflammatory_respons0.99522555
72MP0003195_calcinosis0.99174754
73MP0005253_abnormal_eye_physiology0.98601299
74MP0004142_abnormal_muscle_tone0.98563421
75MP0002429_abnormal_blood_cell0.96358336
76MP0009764_decreased_sensitivity_to0.96115563
77MP0003011_delayed_dark_adaptation0.94596912
78MP0009697_abnormal_copulation0.90743725
79MP0008469_abnormal_protein_level0.85755356
80MP0006276_abnormal_autonomic_nervous0.82898059
81MP0001765_abnormal_ion_homeostasis0.82675617
82MP0001119_abnormal_female_reproductive0.81914215
83MP0003252_abnormal_bile_duct0.79402640
84MP0002693_abnormal_pancreas_physiology0.78570751
85MP0005379_endocrine/exocrine_gland_phen0.78363887
86MP0002095_abnormal_skin_pigmentation0.78190431
87MP0002277_abnormal_respiratory_mucosa0.76626707
88MP0002653_abnormal_ependyma_morphology0.73121699
89MP0001542_abnormal_bone_strength0.72279743
90MP0000678_abnormal_parathyroid_gland0.71176165
91MP0009643_abnormal_urine_homeostasis0.71166188
92MP0003045_fibrosis0.71062610
93MP0010386_abnormal_urinary_bladder0.69804347
94MP0005174_abnormal_tail_pigmentation0.68627567
95MP0002019_abnormal_tumor_incidence0.65811058
96MP0003787_abnormal_imprinting0.64659754
97MP0000230_abnormal_systemic_arterial0.64015809
98MP0000049_abnormal_middle_ear0.63846345
99MP0005464_abnormal_platelet_physiology0.62757376
100MP0001661_extended_life_span0.62475608

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.20573573
2Absent rod-and cone-mediated responses on ERG (HP:0007688)4.13372463
3Aplastic anemia (HP:0001915)3.90280134
4Acute necrotizing encephalopathy (HP:0006965)3.74633200
5Mitochondrial inheritance (HP:0001427)3.64629885
6IgG deficiency (HP:0004315)3.60349804
7Abnormality of B cell number (HP:0010975)3.58016911
8Abnormal rod and cone electroretinograms (HP:0008323)3.50022434
9Elevated erythrocyte sedimentation rate (HP:0003565)3.44934411
10Pancreatic cysts (HP:0001737)3.41497256
11Severe combined immunodeficiency (HP:0004430)3.34726412
12Hypoproteinemia (HP:0003075)3.31817661
13Abnormal mitochondria in muscle tissue (HP:0008316)3.28746408
14Autoimmune hemolytic anemia (HP:0001890)3.23874287
15Increased CSF lactate (HP:0002490)3.21193076
16B lymphocytopenia (HP:0010976)3.20133226
17Progressive macrocephaly (HP:0004481)3.18805091
18Acute encephalopathy (HP:0006846)3.17801427
193-Methylglutaconic aciduria (HP:0003535)3.14918139
20Hepatocellular necrosis (HP:0001404)3.13302683
21Abnormality of T cell number (HP:0011839)3.10715487
22T lymphocytopenia (HP:0005403)3.05865186
23Thyroiditis (HP:0100646)2.94997866
24Hepatic necrosis (HP:0002605)2.92301053
25Abolished electroretinogram (ERG) (HP:0000550)2.88086476
26Abnormality of midbrain morphology (HP:0002418)2.86993473
27Molar tooth sign on MRI (HP:0002419)2.86993473
28Abnormality of cells of the erythroid lineage (HP:0012130)2.84284024
29Increased IgM level (HP:0003496)2.80324495
30Reticulocytopenia (HP:0001896)2.79891831
31Pancreatic fibrosis (HP:0100732)2.77723056
32Attenuation of retinal blood vessels (HP:0007843)2.77598337
33Decreased central vision (HP:0007663)2.77035003
34True hermaphroditism (HP:0010459)2.76129172
35Abnormality of the prostate (HP:0008775)2.73441441
36Increased hepatocellular lipid droplets (HP:0006565)2.65649549
37Type 2 muscle fiber atrophy (HP:0003554)2.63498297
38Pendular nystagmus (HP:0012043)2.56912775
39Abnormality of T cells (HP:0002843)2.55072509
40Abnormal number of erythroid precursors (HP:0012131)2.54908106
41Abnormality of the renal cortex (HP:0011035)2.53029977
42Optic disc pallor (HP:0000543)2.51996505
43Cerebral edema (HP:0002181)2.47559215
44Methylmalonic acidemia (HP:0002912)2.43239261
45Combined immunodeficiency (HP:0005387)2.41013808
46Increased intramyocellular lipid droplets (HP:0012240)2.39279306
47Lipid accumulation in hepatocytes (HP:0006561)2.38072697
48Abnormality of eosinophils (HP:0001879)2.37969774
49Agammaglobulinemia (HP:0004432)2.34460824
50Distal arthrogryposis (HP:0005684)2.33512487
51Stomatitis (HP:0010280)2.32350362
52Renal cortical cysts (HP:0000803)2.30798639
53Panhypogammaglobulinemia (HP:0003139)2.30613391
54Increased serum lactate (HP:0002151)2.30607068
55Decreased electroretinogram (ERG) amplitude (HP:0000654)2.27768972
56Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26080038
57Keratoconus (HP:0000563)2.25967196
58Increased corneal curvature (HP:0100692)2.25967196
59Renal Fanconi syndrome (HP:0001994)2.25316715
60Pancytopenia (HP:0001876)2.23716990
61Methylmalonic aciduria (HP:0012120)2.23492998
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.18201221
63Nephronophthisis (HP:0000090)2.17338984
64Muscle fiber atrophy (HP:0100295)2.11172683
65Constricted visual fields (HP:0001133)2.09928201
66Aplasia/Hypoplasia of the spleen (HP:0010451)2.09912802
67Absent thumb (HP:0009777)2.09458260
68Lactic acidosis (HP:0003128)2.07688085
69Eosinophilia (HP:0001880)2.05043012
70Asplenia (HP:0001746)2.03648694
71Cystic liver disease (HP:0006706)1.99276475
72Abnormality of the renal medulla (HP:0100957)1.99081876
73Macrocytic anemia (HP:0001972)1.98377831
74Symphalangism affecting the phalanges of the hand (HP:0009773)1.98162395
75Stenosis of the external auditory canal (HP:0000402)1.97924019
76Aplasia/hypoplasia of the uterus (HP:0008684)1.97717164
77Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.97634398
78Decreased activity of mitochondrial respiratory chain (HP:0008972)1.97634398
79Increased muscle lipid content (HP:0009058)1.93816065
80Hypoplasia of the uterus (HP:0000013)1.92079953
81Dyschromatopsia (HP:0007641)1.91348561
82Lethargy (HP:0001254)1.91256100
83Abnormality of dicarboxylic acid metabolism (HP:0010995)1.90797484
84Dicarboxylic aciduria (HP:0003215)1.90797484
85Autoimmune thrombocytopenia (HP:0001973)1.90631592
86Prostate neoplasm (HP:0100787)1.88306139
87Congenital, generalized hypertrichosis (HP:0004540)1.88086535
88Respiratory failure (HP:0002878)1.87974179
89Generalized aminoaciduria (HP:0002909)1.86657859
90Absent phalangeal crease (HP:0006109)1.86244155
91Cerebral palsy (HP:0100021)1.84961548
92Colon cancer (HP:0003003)1.83247315
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.80848697
94Abnormality of urine glucose concentration (HP:0011016)1.78957909
95Glycosuria (HP:0003076)1.78957909
96Encephalitis (HP:0002383)1.76101841
97Abnormality of T cell physiology (HP:0011840)1.74237309
98Testicular atrophy (HP:0000029)1.73154310
99Amniotic constriction ring (HP:0009775)1.71663639
100Abnormality of placental membranes (HP:0011409)1.71663639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK4.13451540
2KDR3.76921606
3GRK12.95933723
4VRK22.89806593
5ADRBK22.64332520
6BCKDK2.61053555
7NUAK12.60644626
8MAP4K22.59926975
9CDK192.52793803
10FRK2.46725544
11MAP4K12.38988338
12TESK22.32654597
13ZAK2.22271216
14EIF2AK32.11637672
15TAOK32.06819419
16MST42.06605219
17KIT2.02264673
18TLK11.95536071
19ITK1.82981762
20PASK1.66418917
21STK161.64975053
22MAPKAPK31.59450166
23TIE11.57608039
24FES1.57201045
25TEC1.49587900
26MUSK1.43779526
27MAP3K121.41530612
28VRK11.40221667
29SCYL21.37835580
30SYK1.32674616
31WNK41.28840155
32PIK3CG1.16628819
33LIMK11.11570944
34PINK11.10969724
35BMPR1B1.06980943
36FLT31.05569432
37WNK31.04989691
38BTK1.02788381
39TNK21.01093629
40GRK61.00516658
41INSRR0.99963663
42PRKCQ0.98841470
43IKBKB0.95124687
44OXSR10.94689519
45TAF10.93238090
46MYLK0.89563876
47DAPK10.86742592
48TRPM70.84433552
49STK390.83676550
50LCK0.82782198
51RPS6KB20.76896179
52PIK3CA0.75766544
53CSF1R0.73306966
54JAK30.71782982
55EIF2AK10.70402423
56DAPK20.70268655
57LYN0.69329729
58MAP2K60.68300757
59BUB10.68141035
60ADRBK10.68099597
61MAPKAPK50.67959499
62TRIM280.60000386
63DYRK20.58790305
64GRK70.56666948
65OBSCN0.54876681
66IGF1R0.53737651
67IKBKE0.52245508
68RPS6KA50.52151603
69NLK0.51749379
70NME10.50993014
71MATK0.50718864
72BMPR20.50292844
73EIF2AK20.47046737
74LRRK20.46822542
75MKNK10.45598874
76MAPK130.45200139
77CSNK1G10.44871906
78CSNK1G30.44322917
79RPS6KA40.43420701
80PRKCE0.43380040
81CAMKK20.42719422
82TGFBR10.42233651
83NME20.40880215
84AURKA0.39459894
85DAPK30.39182767
86CSNK2A20.38620368
87MAP3K110.38381788
88PRKCA0.38212675
89PRKACA0.36138719
90ZAP700.35131743
91CSNK2A10.34840120
92CAMK10.32647020
93ACVR1B0.31759676
94CSK0.31223420
95AURKB0.31185572
96GRK50.29604171
97ATR0.29372740
98PLK30.28977802
99CSNK1A10.28431412
100TESK10.27669148

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.85120576
2Ribosome_Homo sapiens_hsa030103.76164731
3Primary immunodeficiency_Homo sapiens_hsa053403.75615180
4Allograft rejection_Homo sapiens_hsa053302.91221079
5Oxidative phosphorylation_Homo sapiens_hsa001902.88616022
6Autoimmune thyroid disease_Homo sapiens_hsa053202.72867913
7Graft-versus-host disease_Homo sapiens_hsa053322.71734051
8Asthma_Homo sapiens_hsa053102.59748081
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.40781660
10Parkinsons disease_Homo sapiens_hsa050122.38820469
11Type I diabetes mellitus_Homo sapiens_hsa049402.35258318
12RNA polymerase_Homo sapiens_hsa030202.23316607
13Antigen processing and presentation_Homo sapiens_hsa046122.14502826
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97500717
15Protein export_Homo sapiens_hsa030601.93158407
16Phototransduction_Homo sapiens_hsa047441.84437017
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.77847606
18Hematopoietic cell lineage_Homo sapiens_hsa046401.69632486
19Homologous recombination_Homo sapiens_hsa034401.69589100
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56944680
21Linoleic acid metabolism_Homo sapiens_hsa005911.54632707
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47071337
23Alzheimers disease_Homo sapiens_hsa050101.44964314
24Huntingtons disease_Homo sapiens_hsa050161.42847386
25Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42728776
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.37495214
27Propanoate metabolism_Homo sapiens_hsa006401.37126204
28Rheumatoid arthritis_Homo sapiens_hsa053231.34853233
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33679582
30RNA degradation_Homo sapiens_hsa030181.31371520
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25846703
32Nitrogen metabolism_Homo sapiens_hsa009101.18593775
33Caffeine metabolism_Homo sapiens_hsa002321.18176818
34Fanconi anemia pathway_Homo sapiens_hsa034601.18010026
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17673174
36One carbon pool by folate_Homo sapiens_hsa006701.17454384
37Pyrimidine metabolism_Homo sapiens_hsa002401.17094364
38Cardiac muscle contraction_Homo sapiens_hsa042601.15165864
39Basal transcription factors_Homo sapiens_hsa030221.07248428
40Nucleotide excision repair_Homo sapiens_hsa034201.02251093
41Chemical carcinogenesis_Homo sapiens_hsa052040.96848928
42Mismatch repair_Homo sapiens_hsa034300.96767402
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.96152666
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95459010
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.95370335
46Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92756093
47T cell receptor signaling pathway_Homo sapiens_hsa046600.91853809
48Viral myocarditis_Homo sapiens_hsa054160.91707702
49Base excision repair_Homo sapiens_hsa034100.91484229
50Peroxisome_Homo sapiens_hsa041460.90391014
51Purine metabolism_Homo sapiens_hsa002300.90291851
52Arachidonic acid metabolism_Homo sapiens_hsa005900.89752088
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.88979246
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88360105
55Butanoate metabolism_Homo sapiens_hsa006500.86949963
56Olfactory transduction_Homo sapiens_hsa047400.84243413
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.83791923
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83463436
59Retinol metabolism_Homo sapiens_hsa008300.82772934
60Tryptophan metabolism_Homo sapiens_hsa003800.82190340
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80164875
62RNA transport_Homo sapiens_hsa030130.77574588
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72467889
64Ether lipid metabolism_Homo sapiens_hsa005650.70304808
65Sulfur metabolism_Homo sapiens_hsa009200.68601035
66Non-homologous end-joining_Homo sapiens_hsa034500.66810711
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.66684697
68Regulation of autophagy_Homo sapiens_hsa041400.66460697
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.66002241
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63667230
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62078922
72DNA replication_Homo sapiens_hsa030300.61105292
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.60406955
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.57878492
75Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55226948
76Spliceosome_Homo sapiens_hsa030400.53956389
77Measles_Homo sapiens_hsa051620.48945046
78Metabolic pathways_Homo sapiens_hsa011000.48458840
79Malaria_Homo sapiens_hsa051440.43574850
80Glutathione metabolism_Homo sapiens_hsa004800.42063572
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41532425
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.41316258
83Ovarian steroidogenesis_Homo sapiens_hsa049130.40394796
84Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39545659
85Herpes simplex infection_Homo sapiens_hsa051680.37729459
86Staphylococcus aureus infection_Homo sapiens_hsa051500.37643272
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37089782
88Systemic lupus erythematosus_Homo sapiens_hsa053220.35823847
89Taste transduction_Homo sapiens_hsa047420.35505206
90Primary bile acid biosynthesis_Homo sapiens_hsa001200.32599384
91RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32054983
92Selenocompound metabolism_Homo sapiens_hsa004500.31805627
93NOD-like receptor signaling pathway_Homo sapiens_hsa046210.26773292
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23673341
95Fatty acid elongation_Homo sapiens_hsa000620.23264522
96Epstein-Barr virus infection_Homo sapiens_hsa051690.23263780
97Fat digestion and absorption_Homo sapiens_hsa049750.22794828
98Salivary secretion_Homo sapiens_hsa049700.21190633
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.20588954
100Leishmaniasis_Homo sapiens_hsa051400.18294055

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