RPL7P10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.50221513
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.66337706
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.65681191
4ATP synthesis coupled proton transport (GO:0015986)4.65681191
5protein neddylation (GO:0045116)4.43036128
6nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)4.21961068
7exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.21053247
8kynurenine metabolic process (GO:0070189)4.07243731
9termination of RNA polymerase III transcription (GO:0006386)4.06155972
10transcription elongation from RNA polymerase III promoter (GO:0006385)4.06155972
11water-soluble vitamin biosynthetic process (GO:0042364)3.95558847
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.74035496
13rRNA modification (GO:0000154)3.72542184
14tryptophan catabolic process (GO:0006569)3.68457645
15indole-containing compound catabolic process (GO:0042436)3.68457645
16indolalkylamine catabolic process (GO:0046218)3.68457645
17behavioral response to nicotine (GO:0035095)3.64134874
18ribosomal small subunit assembly (GO:0000028)3.62097268
19proteasome assembly (GO:0043248)3.55413713
20protein complex biogenesis (GO:0070271)3.54216355
21piRNA metabolic process (GO:0034587)3.47987323
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47083385
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.47083385
24NADH dehydrogenase complex assembly (GO:0010257)3.47083385
25RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.45700191
26ribosomal large subunit biogenesis (GO:0042273)3.39909584
27regulation of isotype switching to IgG isotypes (GO:0048302)3.38237069
28tryptophan metabolic process (GO:0006568)3.33077853
29respiratory chain complex IV assembly (GO:0008535)3.32917545
30electron transport chain (GO:0022900)3.27308968
31respiratory electron transport chain (GO:0022904)3.26270637
32mitochondrial respiratory chain complex assembly (GO:0033108)3.24146339
33regulation of immunoglobulin secretion (GO:0051023)3.21633696
34indolalkylamine metabolic process (GO:0006586)3.18094287
35iron-sulfur cluster assembly (GO:0016226)3.16988513
36metallo-sulfur cluster assembly (GO:0031163)3.16988513
37RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.14804496
38tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.14804496
39chaperone-mediated protein transport (GO:0072321)3.13467209
40cytochrome complex assembly (GO:0017004)3.12123379
41somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.08771874
42somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.08771874
43isotype switching (GO:0045190)3.08771874
44positive regulation of prostaglandin secretion (GO:0032308)3.08058127
45organelle disassembly (GO:1903008)3.07257177
46positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.02054592
47ubiquinone biosynthetic process (GO:0006744)2.94145940
48mannosylation (GO:0097502)2.90910584
49rRNA methylation (GO:0031167)2.86416235
50DNA methylation involved in gamete generation (GO:0043046)2.82719751
51tRNA processing (GO:0008033)2.80969368
52positive regulation of DNA recombination (GO:0045911)2.79476287
53hydrogen ion transmembrane transport (GO:1902600)2.78857948
54GPI anchor metabolic process (GO:0006505)2.76895022
55proton transport (GO:0015992)2.76223411
56base-excision repair, AP site formation (GO:0006285)2.75775267
57DNA demethylation (GO:0080111)2.75429772
58pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.75426076
59protein K6-linked ubiquitination (GO:0085020)2.74729913
60negative regulation of synaptic transmission, GABAergic (GO:0032229)2.74334756
61hydrogen transport (GO:0006818)2.73316247
62ubiquinone metabolic process (GO:0006743)2.72279719
63ribonucleoprotein complex disassembly (GO:0032988)2.69735129
64preassembly of GPI anchor in ER membrane (GO:0016254)2.69592594
65platelet dense granule organization (GO:0060155)2.69159360
66GTP biosynthetic process (GO:0006183)2.68692411
67regulation of cellular amino acid metabolic process (GO:0006521)2.68395985
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67839566
69regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.67823640
70regulation of prostaglandin secretion (GO:0032306)2.67383816
71negative regulation of heart rate (GO:0010459)2.66820124
72protein-cofactor linkage (GO:0018065)2.66048743
73negative regulation of mast cell activation (GO:0033004)2.64555653
74negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.63618025
75cytidine deamination (GO:0009972)2.60495943
76cytidine metabolic process (GO:0046087)2.60495943
77cytidine catabolic process (GO:0006216)2.60495943
78transcription from RNA polymerase III promoter (GO:0006383)2.59825649
79purine nucleoside triphosphate biosynthetic process (GO:0009145)2.59138206
80pseudouridine synthesis (GO:0001522)2.58495500
81purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.57402388
82establishment of protein localization to mitochondrial membrane (GO:0090151)2.56163856
83ATP biosynthetic process (GO:0006754)2.53837117
84rRNA catabolic process (GO:0016075)2.52637922
85mast cell activation (GO:0045576)2.51065511
86regulation of mitotic spindle checkpoint (GO:1903504)2.51045384
87regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.51045384
88L-fucose catabolic process (GO:0042355)2.51035550
89fucose catabolic process (GO:0019317)2.51035550
90L-fucose metabolic process (GO:0042354)2.51035550
91termination of RNA polymerase I transcription (GO:0006363)2.49130433
92DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.48791034
93GPI anchor biosynthetic process (GO:0006506)2.48618615
94endoderm formation (GO:0001706)2.46913208
95transcription elongation from RNA polymerase I promoter (GO:0006362)2.46405769
96signal peptide processing (GO:0006465)2.46379646
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.44366632
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.44366632
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.44366632
100negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.43791873

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.94854631
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.58593369
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.58543410
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.39159158
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95912130
6ZNF274_21170338_ChIP-Seq_K562_Hela2.93736708
7VDR_22108803_ChIP-Seq_LS180_Human2.81882887
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.79444968
9VDR_23849224_ChIP-Seq_CD4+_Human2.59398566
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58991653
11IGF1R_20145208_ChIP-Seq_DFB_Human2.49630409
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48872180
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.30269006
14PCGF2_27294783_Chip-Seq_ESCs_Mouse2.25399639
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22012189
16ELK1_19687146_ChIP-ChIP_HELA_Human2.21062281
17NOTCH1_21737748_ChIP-Seq_TLL_Human2.17607884
18EWS_26573619_Chip-Seq_HEK293_Human2.04461120
19FOXP3_21729870_ChIP-Seq_TREG_Human2.03769155
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.02210012
21IRF1_19129219_ChIP-ChIP_H3396_Human1.93435877
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92766272
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.90154706
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.89519062
25CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81268365
26MYC_18940864_ChIP-ChIP_HL60_Human1.78762948
27MYC_18555785_ChIP-Seq_MESCs_Mouse1.78470279
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.70853059
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.68039718
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.64577140
31ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57958932
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.56438642
33FUS_26573619_Chip-Seq_HEK293_Human1.53569297
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53151934
35PADI4_21655091_ChIP-ChIP_MCF-7_Human1.52765099
36GATA3_26560356_Chip-Seq_TH2_Human1.52654919
37TAF15_26573619_Chip-Seq_HEK293_Human1.52219145
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.52025824
39ER_23166858_ChIP-Seq_MCF-7_Human1.50905589
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43337653
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.42017855
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.41569558
43AUTS2_25519132_ChIP-Seq_293T-REX_Human1.39527355
44IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39252725
45SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39229687
46PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.39103853
47FOXA1_25329375_ChIP-Seq_VCAP_Human1.38268752
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.38268752
49P300_19829295_ChIP-Seq_ESCs_Human1.35578493
50NANOG_19829295_ChIP-Seq_ESCs_Human1.35439466
51SOX2_19829295_ChIP-Seq_ESCs_Human1.35439466
52TP53_22573176_ChIP-Seq_HFKS_Human1.35289363
53TTF2_22483619_ChIP-Seq_HELA_Human1.33451107
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31400616
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.28066707
56MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.25267772
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24652190
58FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23749941
59AR_20517297_ChIP-Seq_VCAP_Human1.23572983
60FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21934654
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.21401021
62CREB1_15753290_ChIP-ChIP_HEK293T_Human1.19474403
63GATA3_21878914_ChIP-Seq_MCF-7_Human1.17860481
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17031570
65CBP_20019798_ChIP-Seq_JUKART_Human1.12171257
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12171257
67CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11207638
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.06827101
69MYC_18358816_ChIP-ChIP_MESCs_Mouse1.05998824
70STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03889603
71YY1_21170310_ChIP-Seq_MESCs_Mouse1.03718532
72ELK1_22589737_ChIP-Seq_MCF10A_Human1.03137012
73TAF2_19829295_ChIP-Seq_ESCs_Human1.01179897
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00925210
75NCOR_22424771_ChIP-Seq_293T_Human1.00380618
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00208565
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99302957
78TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99175677
79HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98306586
80GBX2_23144817_ChIP-Seq_PC3_Human0.98247356
81P53_22387025_ChIP-Seq_ESCs_Mouse0.97904512
82PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97592214
83STAT3_18555785_Chip-Seq_ESCs_Mouse0.96513607
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96453426
85GABP_19822575_ChIP-Seq_HepG2_Human0.96402604
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95681636
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94770128
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.93589159
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92998770
90EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92600298
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.92440128
92TCF4_22108803_ChIP-Seq_LS180_Human0.92089003
93FOXH1_21741376_ChIP-Seq_EPCs_Human0.91713395
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90793414
95NMYC_18555785_Chip-Seq_ESCs_Mouse0.89231625
96EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88592924
97CDX2_22108803_ChIP-Seq_LS180_Human0.87504739
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.87452869
99OCT4_18555785_Chip-Seq_ESCs_Mouse0.87306712
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87203566

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.58289469
2MP0005671_abnormal_response_to3.21206325
3MP0003011_delayed_dark_adaptation3.03497357
4MP0008875_abnormal_xenobiotic_pharmacok2.93382474
5MP0002138_abnormal_hepatobiliary_system2.92001524
6MP0006292_abnormal_olfactory_placode2.51997788
7MP0006072_abnormal_retinal_apoptosis2.39774916
8MP0008872_abnormal_physiological_respon2.38290108
9MP0005646_abnormal_pituitary_gland2.04949662
10MP0001800_abnormal_humoral_immune1.95347144
11MP0001968_abnormal_touch/_nociception1.94936740
12MP0002102_abnormal_ear_morphology1.89116458
13MP0005551_abnormal_eye_electrophysiolog1.88733813
14MP0003806_abnormal_nucleotide_metabolis1.84474563
15MP0003195_calcinosis1.75879227
16MP0000372_irregular_coat_pigmentation1.74704828
17MP0002166_altered_tumor_susceptibility1.74306562
18MP0008877_abnormal_DNA_methylation1.72270605
19MP0001790_abnormal_immune_system1.70789682
20MP0005387_immune_system_phenotype1.70789682
21MP0001293_anophthalmia1.68507849
22MP0003786_premature_aging1.66662301
23MP0002148_abnormal_hypersensitivity_rea1.64000839
24MP0005253_abnormal_eye_physiology1.61234922
25MP0008058_abnormal_DNA_repair1.60184250
26MP0005645_abnormal_hypothalamus_physiol1.53613347
27MP0009764_decreased_sensitivity_to1.52321959
28MP0005000_abnormal_immune_tolerance1.52234165
29MP0001348_abnormal_lacrimal_gland1.50268170
30MP0000685_abnormal_immune_system1.48526292
31MP0009785_altered_susceptibility_to1.48346061
32MP0002006_tumorigenesis1.48336665
33MP0001986_abnormal_taste_sensitivity1.47650775
34MP0002282_abnormal_trachea_morphology1.47379544
35MP0000427_abnormal_hair_cycle1.47048256
36MP0005377_hearing/vestibular/ear_phenot1.44265990
37MP0003878_abnormal_ear_physiology1.44265990
38MP0000569_abnormal_digit_pigmentation1.44100040
39MP0006276_abnormal_autonomic_nervous1.43599729
40MP0002736_abnormal_nociception_after1.43267603
41MP0005167_abnormal_blood-brain_barrier1.41831718
42MP0002723_abnormal_immune_serum1.41514345
43MP0004142_abnormal_muscle_tone1.40221269
44MP0005075_abnormal_melanosome_morpholog1.30553496
45MP0003567_abnormal_fetal_cardiomyocyte1.27386232
46MP0001873_stomach_inflammation1.25592037
47MP0002452_abnormal_antigen_presenting1.24316126
48MP0000383_abnormal_hair_follicle1.22169099
49MP0001501_abnormal_sleep_pattern1.20310100
50MP0004147_increased_porphyrin_level1.18894647
51MP0001819_abnormal_immune_cell1.17759447
52MP0002420_abnormal_adaptive_immunity1.17153482
53MP0008995_early_reproductive_senescence1.12048155
54MP0003638_abnormal_response/metabolism_1.12010260
55MP0002876_abnormal_thyroid_physiology1.12000157
56MP0002277_abnormal_respiratory_mucosa1.10923584
57MP0002163_abnormal_gland_morphology1.10058537
58MP0005084_abnormal_gallbladder_morpholo1.09334424
59MP0004742_abnormal_vestibular_system1.07623204
60MP0006036_abnormal_mitochondrial_physio1.05254937
61MP0003938_abnormal_ear_development1.02836736
62MP0004885_abnormal_endolymph1.02628872
63MP0002272_abnormal_nervous_system1.02434977
64MP0003866_abnormal_defecation1.01175757
65MP0005379_endocrine/exocrine_gland_phen1.00828188
66MP0003724_increased_susceptibility_to1.00079018
67MP0003718_maternal_effect0.99958324
68MP0005389_reproductive_system_phenotype0.99571593
69MP0009745_abnormal_behavioral_response0.99120708
70MP0001486_abnormal_startle_reflex0.98253591
71MP0002234_abnormal_pharynx_morphology0.98173574
72MP0001440_abnormal_grooming_behavior0.96352288
73MP0001529_abnormal_vocalization0.95565147
74MP0003763_abnormal_thymus_physiology0.92769565
75MP0001984_abnormal_olfaction0.91490555
76MP0009697_abnormal_copulation0.91371554
77MP0003252_abnormal_bile_duct0.91005150
78MP0003186_abnormal_redox_activity0.90076819
79MP0002837_dystrophic_cardiac_calcinosis0.89223749
80MP0005174_abnormal_tail_pigmentation0.88157023
81MP0003646_muscle_fatigue0.87760577
82MP0004145_abnormal_muscle_electrophysio0.87579673
83MP0001919_abnormal_reproductive_system0.87430689
84MP0002095_abnormal_skin_pigmentation0.84566337
85MP0001845_abnormal_inflammatory_respons0.83381337
86MP0004215_abnormal_myocardial_fiber0.83231337
87MP0002938_white_spotting0.83011681
88MP0009046_muscle_twitch0.82740077
89MP0000716_abnormal_immune_system0.82621956
90MP0000689_abnormal_spleen_morphology0.80500014
91MP0008775_abnormal_heart_ventricle0.80129737
92MP0003880_abnormal_central_pattern0.79561851
93MP0009379_abnormal_foot_pigmentation0.79522498
94MP0005085_abnormal_gallbladder_physiolo0.79151742
95MP0002733_abnormal_thermal_nociception0.79093669
96MP0010155_abnormal_intestine_physiology0.78149602
97MP0002398_abnormal_bone_marrow0.77495283
98MP0000013_abnormal_adipose_tissue0.76997279
99MP0000647_abnormal_sebaceous_gland0.75041586
100MP0005025_abnormal_response_to0.74340296

Predicted human phenotypes

RankGene SetZ-score
1IgG deficiency (HP:0004315)4.03150087
2Pancreatic cysts (HP:0001737)3.79169943
33-Methylglutaconic aciduria (HP:0003535)3.67694914
4Acute necrotizing encephalopathy (HP:0006965)3.53599588
5True hermaphroditism (HP:0010459)3.49235985
6Pancreatic fibrosis (HP:0100732)3.39973507
7Mitochondrial inheritance (HP:0001427)3.33196911
8Acute encephalopathy (HP:0006846)3.28167282
9Molar tooth sign on MRI (HP:0002419)3.27352591
10Abnormality of midbrain morphology (HP:0002418)3.27352591
11Congenital, generalized hypertrichosis (HP:0004540)3.23981216
12Stomatitis (HP:0010280)3.10362118
13Increased CSF lactate (HP:0002490)3.08844787
14Methylmalonic acidemia (HP:0002912)3.06755337
15Progressive macrocephaly (HP:0004481)3.05185205
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.03449419
17Nephronophthisis (HP:0000090)2.99523543
18Increased hepatocellular lipid droplets (HP:0006565)2.97311582
19Type II lissencephaly (HP:0007260)2.95818159
20Abolished electroretinogram (ERG) (HP:0000550)2.92911988
21Abnormal biliary tract physiology (HP:0012439)2.92739728
22Bile duct proliferation (HP:0001408)2.92739728
23Congenital stationary night blindness (HP:0007642)2.87720471
24Abnormal mitochondria in muscle tissue (HP:0008316)2.86871147
25Abnormal rod and cone electroretinograms (HP:0008323)2.80050721
26Increased IgM level (HP:0003496)2.74703067
27Attenuation of retinal blood vessels (HP:0007843)2.60843193
28Pendular nystagmus (HP:0012043)2.60588188
29Lipid accumulation in hepatocytes (HP:0006561)2.60420250
30Methylmalonic aciduria (HP:0012120)2.56660425
31Hepatocellular necrosis (HP:0001404)2.55187137
32Increased serum lactate (HP:0002151)2.47966171
33Abnormality of the renal medulla (HP:0100957)2.47392667
34Optic disc pallor (HP:0000543)2.45152098
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.40894495
36Increased corneal curvature (HP:0100692)2.40836631
37Keratoconus (HP:0000563)2.40836631
38Decreased central vision (HP:0007663)2.36531763
39Elevated erythrocyte sedimentation rate (HP:0003565)2.35274134
40Panhypogammaglobulinemia (HP:0003139)2.33570182
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.32782470
42Abnormality of alanine metabolism (HP:0010916)2.32782470
43Hyperalaninemia (HP:0003348)2.32782470
44Hypoproteinemia (HP:0003075)2.32642121
45Abnormality of the prostate (HP:0008775)2.31196332
46Aplastic anemia (HP:0001915)2.29872386
47Conical tooth (HP:0000698)2.29798898
48Sclerocornea (HP:0000647)2.27848758
49Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22217194
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.21136064
51Absent/shortened dynein arms (HP:0200106)2.21136064
52Cerebral edema (HP:0002181)2.20794307
53Type 2 muscle fiber atrophy (HP:0003554)2.15881953
54Lactic acidosis (HP:0003128)2.15078527
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.14928532
56Hepatic necrosis (HP:0002605)2.12943987
57Renal Fanconi syndrome (HP:0001994)2.12027838
58Abnormal number of erythroid precursors (HP:0012131)2.08516660
59Abnormality of the renal cortex (HP:0011035)2.07533559
60Exertional dyspnea (HP:0002875)2.05184716
61Lethargy (HP:0001254)2.01533922
62Hypothermia (HP:0002045)2.00591476
63Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99703696
64Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99703696
65Abnormality of the phalanges of the 2nd finger (HP:0009541)1.98807603
66Abnormality of the labia minora (HP:0012880)1.97978369
67Cystic liver disease (HP:0006706)1.97489366
68Severe combined immunodeficiency (HP:0004430)1.95429701
69Thyroiditis (HP:0100646)1.93987843
70Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.93978551
71Pancytopenia (HP:0001876)1.93531353
72Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93433941
73Homocystinuria (HP:0002156)1.92140495
74Abnormality of homocysteine metabolism (HP:0010919)1.92140495
75Abnormality of cells of the erythroid lineage (HP:0012130)1.91207846
76Abnormality of the middle phalanges of the toes (HP:0010183)1.90751729
77Aplasia/hypoplasia of the uterus (HP:0008684)1.89146016
78Abnormality of B cell number (HP:0010975)1.88803429
79Abnormality of serum amino acid levels (HP:0003112)1.88523070
80Oral leukoplakia (HP:0002745)1.87022489
81Stomach cancer (HP:0012126)1.86206925
82Hypoplasia of the uterus (HP:0000013)1.85337627
83Abnormality of the phalanges of the 5th finger (HP:0004213)1.84466479
84Congenital hepatic fibrosis (HP:0002612)1.83089523
85Abnormality of the vitamin B12 metabolism (HP:0004341)1.82466244
86Increased intramyocellular lipid droplets (HP:0012240)1.80016268
87Encephalitis (HP:0002383)1.77347009
88Hyperglycinuria (HP:0003108)1.77325226
89Retrobulbar optic neuritis (HP:0100654)1.77323740
90Optic neuritis (HP:0100653)1.77323740
91Anencephaly (HP:0002323)1.76128690
92Hypoplasia of the ulna (HP:0003022)1.74392978
93Medial flaring of the eyebrow (HP:0010747)1.72975201
94Muscle fiber atrophy (HP:0100295)1.71597763
95B lymphocytopenia (HP:0010976)1.71295611
96Male pseudohermaphroditism (HP:0000037)1.70815428
97Abnormal ciliary motility (HP:0012262)1.69478276
98Retinal dysplasia (HP:0007973)1.69034664
99Abnormal drinking behavior (HP:0030082)1.68962486
100Polydipsia (HP:0001959)1.68962486

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TAOK33.88375332
2TXK3.56223350
3NUAK12.85307358
4TLK12.73947832
5ZAK2.54178287
6STK162.45152349
7FRK2.32474483
8MAP4K22.13750544
9ADRBK22.11145486
10MAP4K12.11023608
11GRK12.05016578
12PINK12.03835684
13CDK191.90732207
14EIF2AK31.60347171
15MST41.56765209
16VRK21.56194907
17TEC1.49089829
18PHKG21.46689821
19PHKG11.46689821
20MAP2K61.43630510
21WNK31.41538716
22PBK1.37821289
23WNK41.37624649
24OXSR11.34246527
25ITK1.31796008
26MAP3K121.31454509
27NME11.29302370
28BCKDK1.28346338
29VRK11.24263856
30PIK3CG1.23516985
31IKBKB1.21905744
32TRIM281.20719482
33BMPR1B1.17264707
34SIK21.15780221
35INSRR1.12829988
36ACVR1B1.09439102
37BCR1.09250277
38SRPK11.06178870
39EIF2AK21.05245857
40SYK1.02691855
41CSNK1G21.01762214
42CSNK1G31.00955254
43CSF1R0.97721337
44GRK60.96004518
45PLK30.95664010
46TIE10.95245340
47MAP3K140.94119400
48MKNK10.92464260
49STK390.92460931
50CDK80.92259989
51IKBKE0.91038694
52FGFR20.90868663
53CSNK1G10.89731442
54DYRK20.89561643
55NEK10.87104417
56MYLK0.84244972
57ERBB30.79883750
58MATK0.79687301
59MAPK130.76897865
60TSSK60.75882607
61KIT0.72179232
62CSNK1A1L0.67262637
63BTK0.65824123
64LYN0.64986899
65IGF1R0.64768447
66RPS6KA50.63687928
67MAP2K70.61711276
68DAPK20.58674790
69KDR0.58239746
70MAP3K40.57576020
71PRKCE0.57360753
72BUB10.56918118
73SCYL20.56867838
74LCK0.56441225
75PLK20.53490422
76PRKCQ0.53425113
77BMPR20.52260158
78TAF10.51118814
79PIK3CA0.51021375
80ADRBK10.49366705
81PLK10.49052678
82FES0.49048048
83TBK10.49032283
84ATR0.48495938
85MKNK20.48458256
86STK38L0.46571965
87ABL10.44838228
88MAPKAPK50.44810150
89DAPK10.44110596
90JAK30.43606889
91MAP2K20.43452242
92OBSCN0.43242146
93GRK50.42341233
94AURKB0.40188395
95SIK30.39534697
96PRKG10.39127630
97MAPKAPK30.37943864
98PRKACA0.37140922
99CSNK2A10.36716647
100ILK0.36572252

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.63205118
2Proteasome_Homo sapiens_hsa030503.30279600
3RNA polymerase_Homo sapiens_hsa030203.01418281
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.97948724
5Oxidative phosphorylation_Homo sapiens_hsa001902.97682120
6Allograft rejection_Homo sapiens_hsa053302.84315447
7Ribosome_Homo sapiens_hsa030102.71332927
8Autoimmune thyroid disease_Homo sapiens_hsa053202.70907654
9Protein export_Homo sapiens_hsa030602.59320244
10Parkinsons disease_Homo sapiens_hsa050122.45064760
11Caffeine metabolism_Homo sapiens_hsa002322.31632391
12Graft-versus-host disease_Homo sapiens_hsa053322.28460074
13Primary immunodeficiency_Homo sapiens_hsa053402.19496691
14Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06601291
15Type I diabetes mellitus_Homo sapiens_hsa049401.82612465
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82128276
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.81871933
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76691841
19Homologous recombination_Homo sapiens_hsa034401.76651403
20RNA degradation_Homo sapiens_hsa030181.74423693
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70591002
22Phototransduction_Homo sapiens_hsa047441.63554882
23Linoleic acid metabolism_Homo sapiens_hsa005911.60516820
24Antigen processing and presentation_Homo sapiens_hsa046121.59636106
25Huntingtons disease_Homo sapiens_hsa050161.58696941
26Basal transcription factors_Homo sapiens_hsa030221.58144277
27Alzheimers disease_Homo sapiens_hsa050101.51709331
28Nitrogen metabolism_Homo sapiens_hsa009101.33051368
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.30770259
30alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.29277040
31Spliceosome_Homo sapiens_hsa030401.27528440
32Pyrimidine metabolism_Homo sapiens_hsa002401.20596297
33Tryptophan metabolism_Homo sapiens_hsa003801.19962294
34Rheumatoid arthritis_Homo sapiens_hsa053231.19069826
35Propanoate metabolism_Homo sapiens_hsa006401.18137824
36Fanconi anemia pathway_Homo sapiens_hsa034601.17358375
37One carbon pool by folate_Homo sapiens_hsa006701.16414353
38Cardiac muscle contraction_Homo sapiens_hsa042601.13403654
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10546727
40Olfactory transduction_Homo sapiens_hsa047401.09788676
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05562049
42RNA transport_Homo sapiens_hsa030131.02220460
43Purine metabolism_Homo sapiens_hsa002300.99081488
44Hematopoietic cell lineage_Homo sapiens_hsa046400.98103954
45Arachidonic acid metabolism_Homo sapiens_hsa005900.97079490
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93009066
47Chemical carcinogenesis_Homo sapiens_hsa052040.87927232
48Peroxisome_Homo sapiens_hsa041460.87140716
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86774475
50Nucleotide excision repair_Homo sapiens_hsa034200.86623800
51Ether lipid metabolism_Homo sapiens_hsa005650.86222524
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84463958
53Mismatch repair_Homo sapiens_hsa034300.79444133
54Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77358087
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.73722083
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73623248
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.72863292
58Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71511855
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.68473047
60Butanoate metabolism_Homo sapiens_hsa006500.65760646
61Base excision repair_Homo sapiens_hsa034100.63816307
62Retinol metabolism_Homo sapiens_hsa008300.62668172
63Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62462873
64Non-homologous end-joining_Homo sapiens_hsa034500.60633644
65Collecting duct acid secretion_Homo sapiens_hsa049660.59986669
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.58454193
67Selenocompound metabolism_Homo sapiens_hsa004500.57545769
68NF-kappa B signaling pathway_Homo sapiens_hsa040640.56555913
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55830846
70Metabolic pathways_Homo sapiens_hsa011000.54643281
71Systemic lupus erythematosus_Homo sapiens_hsa053220.52759633
72Fat digestion and absorption_Homo sapiens_hsa049750.52238555
73Regulation of autophagy_Homo sapiens_hsa041400.51639253
74Viral myocarditis_Homo sapiens_hsa054160.51506049
75Taste transduction_Homo sapiens_hsa047420.49954968
76Sulfur metabolism_Homo sapiens_hsa009200.47653720
77DNA replication_Homo sapiens_hsa030300.46835364
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.46149671
79Nicotine addiction_Homo sapiens_hsa050330.45695892
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.45631944
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45071832
82Sulfur relay system_Homo sapiens_hsa041220.44656791
83Epstein-Barr virus infection_Homo sapiens_hsa051690.43426253
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41717524
85T cell receptor signaling pathway_Homo sapiens_hsa046600.41714263
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41652229
87Staphylococcus aureus infection_Homo sapiens_hsa051500.40624369
88Pyruvate metabolism_Homo sapiens_hsa006200.39409426
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.37598778
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.36372010
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36336550
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.35544565
93Serotonergic synapse_Homo sapiens_hsa047260.34780873
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.34546193
95Leishmaniasis_Homo sapiens_hsa051400.32916325
96Glutathione metabolism_Homo sapiens_hsa004800.32787303
97Glycerolipid metabolism_Homo sapiens_hsa005610.30967434
98Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28615841
99Fatty acid biosynthesis_Homo sapiens_hsa000610.26290691
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.26132849

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