ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ATP synthesis coupled proton transport (GO:0015986)	4.67087242
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.67087242
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.66368217
4	proteasome assembly (GO:0043248)	4.26033662
5	DNA deamination (GO:0045006)	4.25884572
6	response to gravity (GO:0009629)	4.19740549
7	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.07710423
8	ribosomal small subunit assembly (GO:0000028)	4.03928655
9	protein polyglutamylation (GO:0018095)	3.92604056
10	protein complex biogenesis (GO:0070271)	3.90172970
11	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.86359765
12	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.86359765
13	NADH dehydrogenase complex assembly (GO:0010257)	3.86359765
14	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.82120403
15	rRNA modification (GO:0000154)	3.81008439
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.80288787
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.76883585
18	ribosomal large subunit biogenesis (GO:0042273)	3.69741681
19	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.63608111
20	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.63044291
21	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	3.60510718
22	termination of RNA polymerase III transcription (GO:0006386)	3.59770234
23	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.59770234
24	chaperone-mediated protein transport (GO:0072321)	3.50851892
25	protein neddylation (GO:0045116)	3.46543328
26	rRNA methylation (GO:0031167)	3.43352405
27	GTP biosynthetic process (GO:0006183)	3.42066794
28	respiratory electron transport chain (GO:0022904)	3.40723525
29	electron transport chain (GO:0022900)	3.39946444
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.28100255
31	cullin deneddylation (GO:0010388)	3.24373220
32	behavioral response to nicotine (GO:0035095)	3.20998739
33	respiratory chain complex IV assembly (GO:0008535)	3.15556470
34	cytochrome complex assembly (GO:0017004)	3.13010378
35	striated muscle atrophy (GO:0014891)	3.10655418
36	protein deneddylation (GO:0000338)	3.10266883
37	pseudouridine synthesis (GO:0001522)	3.06679283
38	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.04422934
39	spliceosomal complex assembly (GO:0000245)	3.03557854
40	UTP biosynthetic process (GO:0006228)	3.02142430
41	maturation of 5.8S rRNA (GO:0000460)	3.01673775
42	rRNA processing (GO:0006364)	2.99896607
43	rRNA metabolic process (GO:0016072)	2.96084561
44	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.95638980
45	isotype switching (GO:0045190)	2.95638980
46	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.95638980
47	UTP metabolic process (GO:0046051)	2.94053780
48	skeletal muscle adaptation (GO:0043501)	2.92818048
49	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.90339716
50	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.86879478
51	regulation of mitotic spindle checkpoint (GO:1903504)	2.84858982
52	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.84858982
53	muscle atrophy (GO:0014889)	2.84476374
54	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.82572856
55	protein-cofactor linkage (GO:0018065)	2.82010406
56	negative regulation of mast cell activation (GO:0033004)	2.81520808
57	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.81108898
58	postreplication repair (GO:0006301)	2.80715898
59	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.80488722
60	negative regulation of heart rate (GO:0010459)	2.79755993
61	regulation of cellular amino acid metabolic process (GO:0006521)	2.77951004
62	L-fucose catabolic process (GO:0042355)	2.77813558
63	fucose catabolic process (GO:0019317)	2.77813558
64	L-fucose metabolic process (GO:0042354)	2.77813558
65	organelle disassembly (GO:1903008)	2.77463694
66	pyrimidine nucleotide catabolic process (GO:0006244)	2.74780270
67	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.74171521
68	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.73953873
69	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.73953873
70	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.73953873
71	replication fork processing (GO:0031297)	2.72514716
72	DNA double-strand break processing (GO:0000729)	2.71232793
73	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.71174905
74	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.71174905
75	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.70459526
76	negative regulation of ligase activity (GO:0051352)	2.70254761
77	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.70254761
78	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.70186541
79	base-excision repair, AP site formation (GO:0006285)	2.67647215
80	translation (GO:0006412)	2.66716336
81	termination of RNA polymerase I transcription (GO:0006363)	2.62311854
82	tRNA processing (GO:0008033)	2.61898623
83	platelet dense granule organization (GO:0060155)	2.61896227
84	ATP biosynthetic process (GO:0006754)	2.61859036
85	skeletal muscle tissue regeneration (GO:0043403)	2.60895649
86	spliceosomal snRNP assembly (GO:0000387)	2.60581412
87	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.60331896
88	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.60331896
89	cellular component biogenesis (GO:0044085)	2.60017463
90	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.59541254
91	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.59203609
92	transcription elongation from RNA polymerase I promoter (GO:0006362)	2.58520963
93	hydrogen ion transmembrane transport (GO:1902600)	2.58064323
94	regulation of skeletal muscle contraction (GO:0014819)	2.57761918
95	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.57662645
96	protein K6-linked ubiquitination (GO:0085020)	2.56227795
97	prenylation (GO:0097354)	2.55401476
98	protein prenylation (GO:0018342)	2.55401476
99	regulation of immunoglobulin secretion (GO:0051023)	2.53622536
100	proton transport (GO:0015992)	2.53505882

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.39909293
2	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.18813004
3	VDR_22108803_ChIP-Seq_LS180_Human	3.99222817
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.74381164
5	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.72737045
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.84202635
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.75369880
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.67681797
9	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.64378390
10	FUS_26573619_Chip-Seq_HEK293_Human	2.50260282
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.45025777
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.43933949
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.43150837
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.38525970
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37849299
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.32121977
17	TAF15_26573619_Chip-Seq_HEK293_Human	2.30532165
18	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.11794491
19	EWS_26573619_Chip-Seq_HEK293_Human	2.00303069
20	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.99376054
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.98149968
22	FOXP3_21729870_ChIP-Seq_TREG_Human	1.95965338
23	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.86869127
24	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.84279818
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82156020
26	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.79731055
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.79490791
28	IGF1R_20145208_ChIP-Seq_DFB_Human	1.78894107
29	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.76631052
30	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.75523293
31	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.74805296
32	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.74793270
33	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.73632895
34	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.71300178
35	MYC_18940864_ChIP-ChIP_HL60_Human	1.64044714
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.54115429
37	P300_19829295_ChIP-Seq_ESCs_Human	1.53980711
38	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53239114
39	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.51257679
40	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.50533227
41	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.49528771
42	TP53_22573176_ChIP-Seq_HFKS_Human	1.49500366
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.48049926
44	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.43686556
45	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37581366
46	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.35230884
47	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.31635344
48	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.31358094
49	TTF2_22483619_ChIP-Seq_HELA_Human	1.31007408
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30026435
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30026435
52	DCP1A_22483619_ChIP-Seq_HELA_Human	1.29831711
53	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.28638098
54	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.25363909
55	AR_20517297_ChIP-Seq_VCAP_Human	1.24852377
56	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24335958
57	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24335958
58	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.22325843
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.20879408
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.20879408
61	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16748201
62	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.16145354
63	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.12517684
64	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.11109116
65	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.10272909
66	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.09159893
67	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.08646916
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.08500342
69	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.07897780
70	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07608730
71	IRF1_19129219_ChIP-ChIP_H3396_Human	1.07537119
72	GATA3_26560356_Chip-Seq_TH2_Human	1.06024412
73	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.04652884
74	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.04509857
75	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.03335438
76	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.01536463
77	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.99612048
78	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.99114478
79	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.97466461
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96610294
81	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.95129011
82	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.94997123
83	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.94055512
84	GABP_19822575_ChIP-Seq_HepG2_Human	0.93383627
85	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.93039003
86	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.91942546
87	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.91651408
88	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90547121
89	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.89179318
90	ERG_20517297_ChIP-Seq_VCAP_Human	0.88345486
91	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.87745310
92	NCOR_22424771_ChIP-Seq_293T_Human	0.87736046
93	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.87661854
94	TCF4_22108803_ChIP-Seq_LS180_Human	0.87146017
95	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.87069171
96	GATA1_22025678_ChIP-Seq_K562_Human	0.85527125
97	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.85521260
98	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.85460234
99	CDX2_22108803_ChIP-Seq_LS180_Human	0.85160160
100	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	0.84898917

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	3.49153697
2	MP0008875_abnormal_xenobiotic_pharmacok	3.12787835
3	MP0002837_dystrophic_cardiac_calcinosis	3.00070083
4	MP0003646_muscle_fatigue	2.88597697
5	MP0002102_abnormal_ear_morphology	2.82925113
6	MP0001835_abnormal_antigen_presentation	2.78038325
7	MP0006072_abnormal_retinal_apoptosis	2.62426819
8	MP0003718_maternal_effect	2.41266904
9	MP0004147_increased_porphyrin_level	2.32037669
10	MP0003786_premature_aging	2.31809672
11	MP0003195_calcinosis	2.25484303
12	MP0001986_abnormal_taste_sensitivity	2.23546100
13	MP0000569_abnormal_digit_pigmentation	2.23456537
14	MP0008872_abnormal_physiological_respon	2.12949479
15	MP0006036_abnormal_mitochondrial_physio	2.10747163
16	MP0000372_irregular_coat_pigmentation	2.05590599
17	MP0001968_abnormal_touch/_nociception	2.01054977
18	MP0006292_abnormal_olfactory_placode	1.99389221
19	MP0002138_abnormal_hepatobiliary_system	1.98573342
20	MP0006035_abnormal_mitochondrial_morpho	1.96180904
21	MP0002736_abnormal_nociception_after	1.90738395
22	MP0004142_abnormal_muscle_tone	1.85496725
23	MP0008058_abnormal_DNA_repair	1.78881586
24	MP0008877_abnormal_DNA_methylation	1.75871580
25	MP0008007_abnormal_cellular_replicative	1.74832051
26	MP0005646_abnormal_pituitary_gland	1.74672118
27	MP0005084_abnormal_gallbladder_morpholo	1.69723392
28	MP0002277_abnormal_respiratory_mucosa	1.68716600
29	MP0005367_renal/urinary_system_phenotyp	1.66363510
30	MP0000516_abnormal_urinary_system	1.66363510
31	MP0004036_abnormal_muscle_relaxation	1.65282126
32	MP0005645_abnormal_hypothalamus_physiol	1.64412900
33	MP0005551_abnormal_eye_electrophysiolog	1.63934368
34	MP0002876_abnormal_thyroid_physiology	1.62762478
35	MP0002234_abnormal_pharynx_morphology	1.60714939
36	MP0003806_abnormal_nucleotide_metabolis	1.51025472
37	MP0003011_delayed_dark_adaptation	1.49784743
38	MP0008995_early_reproductive_senescence	1.47489876
39	MP0002148_abnormal_hypersensitivity_rea	1.45233785
40	MP0000685_abnormal_immune_system	1.44784506
41	MP0004885_abnormal_endolymph	1.39322109
42	MP0001529_abnormal_vocalization	1.39233650
43	MP0000427_abnormal_hair_cycle	1.36784632
44	MP0004084_abnormal_cardiac_muscle	1.32458430
45	MP0004957_abnormal_blastocyst_morpholog	1.30198586
46	MP0001293_anophthalmia	1.27028756
47	MP0005389_reproductive_system_phenotype	1.19275045
48	MP0010094_abnormal_chromosome_stability	1.17682680
49	MP0002095_abnormal_skin_pigmentation	1.16598861
50	MP0009764_decreased_sensitivity_to	1.14776701
51	MP0005253_abnormal_eye_physiology	1.12066328
52	MP0003890_abnormal_embryonic-extraembry	1.11820731
53	MP0010386_abnormal_urinary_bladder	1.09550779
54	MP0001485_abnormal_pinna_reflex	1.07714493
55	MP0001800_abnormal_humoral_immune	1.07086663
56	MP0005174_abnormal_tail_pigmentation	1.06190821
57	MP0003724_increased_susceptibility_to	1.04452216
58	MP0003567_abnormal_fetal_cardiomyocyte	1.00963670
59	MP0005671_abnormal_response_to	1.00797708
60	MP0000747_muscle_weakness	1.00725752
61	MP0003186_abnormal_redox_activity	0.97635870
62	MP0002160_abnormal_reproductive_system	0.96210282
63	MP0004043_abnormal_pH_regulation	0.94192750
64	MP0000647_abnormal_sebaceous_gland	0.92570894
65	MP0005636_abnormal_mineral_homeostasis	0.91277024
66	MP0009697_abnormal_copulation	0.90002373
67	MP0001919_abnormal_reproductive_system	0.89503308
68	MP0002006_tumorigenesis	0.85146223
69	MP0002751_abnormal_autonomic_nervous	0.84877118
70	MP0001790_abnormal_immune_system	0.84081715
71	MP0005387_immune_system_phenotype	0.84081715
72	MP0005083_abnormal_biliary_tract	0.83515037
73	MP0009379_abnormal_foot_pigmentation	0.83294079
74	MP0002938_white_spotting	0.78745852
75	MP0001984_abnormal_olfaction	0.77956493
76	MP0001881_abnormal_mammary_gland	0.77642704
77	MP0004215_abnormal_myocardial_fiber	0.77465704
78	MP0002106_abnormal_muscle_physiology	0.77443309
79	MP0002272_abnormal_nervous_system	0.75947818
80	MP0002396_abnormal_hematopoietic_system	0.75249172
81	MP0002269_muscular_atrophy	0.74461513
82	MP0001905_abnormal_dopamine_level	0.73616424
83	MP0003787_abnormal_imprinting	0.72245211
84	MP0002723_abnormal_immune_serum	0.72080431
85	MP0002733_abnormal_thermal_nociception	0.72038899
86	MP0003252_abnormal_bile_duct	0.70770167
87	MP0009785_altered_susceptibility_to	0.70088810
88	MP0005000_abnormal_immune_tolerance	0.69378162
89	MP0003638_abnormal_response/metabolism_	0.67685668
90	MP0005075_abnormal_melanosome_morpholog	0.67519015
91	MP0009745_abnormal_behavioral_response	0.67384119
92	MP0003937_abnormal_limbs/digits/tail_de	0.66532030
93	MP0002452_abnormal_antigen_presenting	0.64747831
94	MP0009250_abnormal_appendicular_skeleto	0.64610823
95	MP0001501_abnormal_sleep_pattern	0.63898951
96	MP0001243_abnormal_dermal_layer	0.63820631
97	MP0001970_abnormal_pain_threshold	0.63767134
98	MP0005620_abnormal_muscle_contractility	0.62695395
99	MP0000631_abnormal_neuroendocrine_gland	0.62638969
100	MP0000230_abnormal_systemic_arterial	0.62075699

Predicted human phenotypes

Rank	Gene Set	Z-score
1	3-Methylglutaconic aciduria (HP:0003535)	5.08311843
2	Acute necrotizing encephalopathy (HP:0006965)	4.91884338
3	Acute encephalopathy (HP:0006846)	4.36654308
4	Progressive macrocephaly (HP:0004481)	4.16508527
5	Abnormal mitochondria in muscle tissue (HP:0008316)	4.16124984
6	Mitochondrial inheritance (HP:0001427)	4.03475469
7	Increased CSF lactate (HP:0002490)	3.77588079
8	Congenital, generalized hypertrichosis (HP:0004540)	3.64741193
9	Pancreatic cysts (HP:0001737)	3.55646070
10	Hepatocellular necrosis (HP:0001404)	3.30654869
11	Increased hepatocellular lipid droplets (HP:0006565)	3.26864269
12	Abnormality of midbrain morphology (HP:0002418)	3.25835710
13	Molar tooth sign on MRI (HP:0002419)	3.25835710
14	Pancreatic fibrosis (HP:0100732)	3.22930874
15	Pendular nystagmus (HP:0012043)	3.18591691
16	Lipid accumulation in hepatocytes (HP:0006561)	3.06143337
17	Congenital stationary night blindness (HP:0007642)	3.02055710
18	Abnormality of alanine metabolism (HP:0010916)	2.95621049
19	Hyperalaninemia (HP:0003348)	2.95621049
20	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.95621049
21	Cerebral edema (HP:0002181)	2.94125500
22	True hermaphroditism (HP:0010459)	2.93746459
23	Stomatitis (HP:0010280)	2.92315114
24	Optic disc pallor (HP:0000543)	2.85402382
25	Hepatic necrosis (HP:0002605)	2.83398958
26	Increased serum lactate (HP:0002151)	2.68245451
27	Abolished electroretinogram (ERG) (HP:0000550)	2.67831832
28	Decreased central vision (HP:0007663)	2.67369030
29	Exertional dyspnea (HP:0002875)	2.60996492
30	Nephronophthisis (HP:0000090)	2.54341424
31	Lactic acidosis (HP:0003128)	2.50987175
32	Hypoplasia of the uterus (HP:0000013)	2.46679473
33	Attenuation of retinal blood vessels (HP:0007843)	2.46240855
34	Delayed CNS myelination (HP:0002188)	2.41680097
35	Palpebral edema (HP:0100540)	2.41465156
36	Aplasia/hypoplasia of the uterus (HP:0008684)	2.37050466
37	Leukodystrophy (HP:0002415)	2.36717266
38	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.36522615
39	Type II lissencephaly (HP:0007260)	2.34642665
40	Methylmalonic acidemia (HP:0002912)	2.29273499
41	Renal Fanconi syndrome (HP:0001994)	2.27459684
42	Supernumerary spleens (HP:0009799)	2.26029457
43	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.25980731
44	Hypoproteinemia (HP:0003075)	2.25051140
45	Exercise intolerance (HP:0003546)	2.24322453
46	Abnormal rod and cone electroretinograms (HP:0008323)	2.24291671
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.19789358
48	Abnormality of the prostate (HP:0008775)	2.16544454
49	Respiratory failure (HP:0002878)	2.16152947
50	Absent phalangeal crease (HP:0006109)	2.15485081
51	Thyroid-stimulating hormone excess (HP:0002925)	2.11117370
52	Type 2 muscle fiber atrophy (HP:0003554)	2.10055542
53	Abnormality of the renal medulla (HP:0100957)	2.08187690
54	Abnormal respiratory epithelium morphology (HP:0012253)	2.07673953
55	Abnormal respiratory motile cilium morphology (HP:0005938)	2.07673953
56	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.07665485
57	Keratoconus (HP:0000563)	2.04425569
58	Increased corneal curvature (HP:0100692)	2.04425569
59	Absent/shortened dynein arms (HP:0200106)	2.03135000
60	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.03135000
61	IgG deficiency (HP:0004315)	2.01287325
62	Rectovaginal fistula (HP:0000143)	1.98492387
63	Rectal fistula (HP:0100590)	1.98492387
64	Adactyly (HP:0009776)	1.94829693
65	Furrowed tongue (HP:0000221)	1.93923139
66	Increased intramyocellular lipid droplets (HP:0012240)	1.93385393
67	Distal arthrogryposis (HP:0005684)	1.92559869
68	Oral leukoplakia (HP:0002745)	1.91831253
69	Azoospermia (HP:0000027)	1.91217758
70	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.91150634
71	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.91150634
72	Abnormality of serum amino acid levels (HP:0003112)	1.90381383
73	Abnormality of cells of the erythroid lineage (HP:0012130)	1.88839129
74	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.88647011
75	Constricted visual fields (HP:0001133)	1.88389188
76	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.87292502
77	Abnormal finger flexion creases (HP:0006143)	1.84212059
78	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.84210775
79	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.81654939
80	Nemaline bodies (HP:0003798)	1.80929829
81	Dyschromatopsia (HP:0007641)	1.80319406
82	X-linked dominant inheritance (HP:0001423)	1.80307378
83	Medial flaring of the eyebrow (HP:0010747)	1.79608814
84	Abnormal number of erythroid precursors (HP:0012131)	1.77852125
85	Decreased circulating renin level (HP:0003351)	1.77727439
86	Chronic hepatic failure (HP:0100626)	1.77385976
87	Meckel diverticulum (HP:0002245)	1.76891640
88	Lethargy (HP:0001254)	1.76828003
89	Congenital hepatic fibrosis (HP:0002612)	1.76338838
90	Methylmalonic aciduria (HP:0012120)	1.75617460
91	Cystic liver disease (HP:0006706)	1.74981080
92	Round ear (HP:0100830)	1.74558464
93	Fibular aplasia (HP:0002990)	1.74312442
94	Aplastic anemia (HP:0001915)	1.73724388
95	Panhypogammaglobulinemia (HP:0003139)	1.73512757
96	Abnormal spermatogenesis (HP:0008669)	1.72471155
97	Abnormality of the ileum (HP:0001549)	1.71634006
98	Abnormality of macular pigmentation (HP:0008002)	1.70588297
99	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.70180264
100	Central scotoma (HP:0000603)	1.69663639

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MAP4K2	3.42399597
2	NUAK1	3.41989052
3	VRK2	3.08714694
4	EIF2AK3	3.08689646
5	MST4	2.61862927
6	TAOK3	2.56982839
7	STK16	2.45517027
8	FRK	2.32267441
9	TLK1	2.25462964
10	INSRR	2.13783632
11	TIE1	2.12662048
12	MAP3K12	2.09875267
13	MKNK1	1.97986632
14	ZAK	1.97050400
15	PBK	1.95793316
16	TAF1	1.80426706
17	EIF2AK1	1.76580412
18	OXSR1	1.75710927
19	PHKG1	1.73553863
20	PHKG2	1.73553863
21	ADRBK2	1.69169835
22	TXK	1.60455560
23	TSSK6	1.57706220
24	NME2	1.48614537
25	GRK1	1.40496229
26	WNK4	1.31149056
27	BRSK2	1.29847656
28	MAPKAPK5	1.29394683
29	TEC	1.28438708
30	VRK1	1.26644468
31	PLK4	1.26185309
32	NME1	1.25330757
33	CAMKK2	1.25174204
34	FLT3	1.20719751
35	DYRK2	1.17227482
36	PLK3	1.14176489
37	OBSCN	1.13337239
38	PLK2	1.13240578
39	SRPK1	1.10282729
40	BUB1	1.09233417
41	MAPK13	1.05908053
42	NEK1	1.04286880
43	PKN1	1.03905468
44	EIF2AK2	1.02766439
45	CDC7	1.02555114
46	TNIK	0.98704413
47	CDK19	0.98528045
48	STK39	0.98442372
49	DAPK1	0.96101358
50	IKBKB	0.95633844
51	CSF1R	0.95470720
52	DAPK2	0.95044930
53	PIK3CA	0.93074636
54	CSNK1G3	0.92176355
55	KIT	0.91008664
56	CSNK1A1L	0.88811906
57	MKNK2	0.88173043
58	CSNK1G2	0.86963158
59	BMPR1B	0.85993888
60	CSNK1G1	0.84162599
61	PIK3CG	0.81877746
62	ERBB3	0.80289825
63	BCKDK	0.77705312
64	BMPR2	0.72488667
65	WNK3	0.69387718
66	ITK	0.67635886
67	BCR	0.67596864
68	CHEK2	0.66290256
69	MYLK	0.62398266
70	BTK	0.56161767
71	ILK	0.55780381
72	ATR	0.54372539
73	WNK1	0.52815855
74	RPS6KA5	0.52577532
75	DAPK3	0.51416353
76	AURKB	0.49566482
77	TRPM7	0.46749169
78	IGF1R	0.42501322
79	LYN	0.42417571
80	STK38L	0.41799035
81	GRK5	0.41636393
82	JAK3	0.39270462
83	CSNK2A1	0.38648294
84	ACVR1B	0.38282657
85	PRKCQ	0.37264220
86	SYK	0.36473466
87	MAP4K1	0.35436578
88	ADRBK1	0.33881536
89	EGFR	0.32837959
90	LCK	0.32406219
91	PRKCE	0.31623127
92	CSNK2A2	0.31588934
93	MAP3K14	0.31508606
94	MAPKAPK3	0.31353087
95	ATM	0.30387329
96	FES	0.29963353
97	CHUK	0.29556279
98	PLK1	0.29003549
99	TRIM28	0.28288895
100	LMTK2	0.27999408

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.42775616
2	Proteasome_Homo sapiens_hsa03050	3.80702194
3	Oxidative phosphorylation_Homo sapiens_hsa00190	3.11379915
4	Allograft rejection_Homo sapiens_hsa05330	3.05974646
5	Ribosome_Homo sapiens_hsa03010	3.02746362
6	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.94359836
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.83926973
8	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.43553273
9	RNA polymerase_Homo sapiens_hsa03020	2.43550899
10	Parkinsons disease_Homo sapiens_hsa05012	2.42549055
11	Protein export_Homo sapiens_hsa03060	2.38526545
12	Graft-versus-host disease_Homo sapiens_hsa05332	2.34122113
13	Type I diabetes mellitus_Homo sapiens_hsa04940	2.12911985
14	Homologous recombination_Homo sapiens_hsa03440	2.12372162
15	One carbon pool by folate_Homo sapiens_hsa00670	2.05534926
16	RNA degradation_Homo sapiens_hsa03018	1.96796770
17	Spliceosome_Homo sapiens_hsa03040	1.82813641
18	Alzheimers disease_Homo sapiens_hsa05010	1.63933242
19	Mismatch repair_Homo sapiens_hsa03430	1.59240143
20	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.57393917
21	Basal transcription factors_Homo sapiens_hsa03022	1.56721713
22	Fanconi anemia pathway_Homo sapiens_hsa03460	1.55944396
23	Huntingtons disease_Homo sapiens_hsa05016	1.55341369
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.54601318
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.42939842
26	Antigen processing and presentation_Homo sapiens_hsa04612	1.40170952
27	Nucleotide excision repair_Homo sapiens_hsa03420	1.37923538
28	Nitrogen metabolism_Homo sapiens_hsa00910	1.34767951
29	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33437900
30	Phototransduction_Homo sapiens_hsa04744	1.30609657
31	DNA replication_Homo sapiens_hsa03030	1.28701223
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.28044687
33	RNA transport_Homo sapiens_hsa03013	1.27535712
34	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.25817158
35	Rheumatoid arthritis_Homo sapiens_hsa05323	1.23755851
36	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.22640501
37	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15151933
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.13418618
39	Purine metabolism_Homo sapiens_hsa00230	1.07520372
40	Caffeine metabolism_Homo sapiens_hsa00232	1.06253573
41	Selenocompound metabolism_Homo sapiens_hsa00450	1.05794635
42	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.04764844
43	Non-homologous end-joining_Homo sapiens_hsa03450	1.02457023
44	Tryptophan metabolism_Homo sapiens_hsa00380	1.02336357
45	Regulation of autophagy_Homo sapiens_hsa04140	0.98963806
46	Propanoate metabolism_Homo sapiens_hsa00640	0.96811044
47	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.96360841
48	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91838240
49	Viral myocarditis_Homo sapiens_hsa05416	0.90898513
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.89701525
51	Primary immunodeficiency_Homo sapiens_hsa05340	0.85711533
52	Ether lipid metabolism_Homo sapiens_hsa00565	0.85614099
53	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.80645555
54	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.77743651
55	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.77465857
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.74599114
57	Base excision repair_Homo sapiens_hsa03410	0.74528828
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.73536498
59	Nicotine addiction_Homo sapiens_hsa05033	0.70585988
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.69506232
61	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.67180323
62	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.66179473
63	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.65412596
64	Olfactory transduction_Homo sapiens_hsa04740	0.64336274
65	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.61224337
66	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.58919360
67	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.58171579
68	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56290612
69	Taste transduction_Homo sapiens_hsa04742	0.54473135
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.50671457
71	Leishmaniasis_Homo sapiens_hsa05140	0.49982452
72	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.49621149
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.48617537
74	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.48149180
75	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.45191662
76	Butanoate metabolism_Homo sapiens_hsa00650	0.44385160
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41238686
78	Herpes simplex infection_Homo sapiens_hsa05168	0.40699092
79	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.40416637
80	Metabolic pathways_Homo sapiens_hsa01100	0.40174927
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.39935662
82	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.35773129
83	Morphine addiction_Homo sapiens_hsa05032	0.32002456
84	Glutathione metabolism_Homo sapiens_hsa00480	0.31903535
85	Sulfur metabolism_Homo sapiens_hsa00920	0.31553778
86	Pyruvate metabolism_Homo sapiens_hsa00620	0.30908988
87	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.29337021
88	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.28397147
89	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.28250391
90	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27963107
91	Retinol metabolism_Homo sapiens_hsa00830	0.27346316
92	Collecting duct acid secretion_Homo sapiens_hsa04966	0.26976024
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.26080079
94	Serotonergic synapse_Homo sapiens_hsa04726	0.24447193
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.24123610
96	mRNA surveillance pathway_Homo sapiens_hsa03015	0.22722144
97	Salivary secretion_Homo sapiens_hsa04970	0.18955391
98	Tight junction_Homo sapiens_hsa04530	0.17495829
99	Peroxisome_Homo sapiens_hsa04146	0.17243075
100	Fat digestion and absorption_Homo sapiens_hsa04975	0.16784041

RPL7P11

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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