RPL7P12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.79975428
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.42768910
3ATP synthesis coupled proton transport (GO:0015986)4.42768910
4kynurenine metabolic process (GO:0070189)4.15278877
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.11837987
6ribosomal large subunit biogenesis (GO:0042273)4.07626820
7indole-containing compound catabolic process (GO:0042436)3.90399773
8indolalkylamine catabolic process (GO:0046218)3.90399773
9tryptophan catabolic process (GO:0006569)3.90399773
10ribosomal small subunit assembly (GO:0000028)3.81367167
11exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.75104955
12tryptophan metabolic process (GO:0006568)3.72154332
13nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.71474716
14regulation of immunoglobulin secretion (GO:0051023)3.61853923
15maturation of SSU-rRNA (GO:0030490)3.61038524
16positive regulation of prostaglandin secretion (GO:0032308)3.59174395
17mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.47148347
18preassembly of GPI anchor in ER membrane (GO:0016254)3.40955585
19cellular response to exogenous dsRNA (GO:0071360)3.37706407
20pseudouridine synthesis (GO:0001522)3.36159153
21rRNA modification (GO:0000154)3.34123252
22somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28414121
23isotype switching (GO:0045190)3.28414121
24somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28414121
25maturation of 5.8S rRNA (GO:0000460)3.22741242
26positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.22729579
27platelet dense granule organization (GO:0060155)3.18626517
28RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.15955216
29response to interferon-beta (GO:0035456)3.15660075
30indolalkylamine metabolic process (GO:0006586)3.14715015
31water-soluble vitamin biosynthetic process (GO:0042364)3.12877456
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.10507853
33regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.10309105
34electron transport chain (GO:0022900)3.09814108
35respiratory electron transport chain (GO:0022904)3.07520778
36negative regulation of mast cell activation (GO:0033004)3.05634148
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04875364
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04875364
39transcription elongation from RNA polymerase III promoter (GO:0006385)3.04311285
40termination of RNA polymerase III transcription (GO:0006386)3.04311285
41protein-cofactor linkage (GO:0018065)3.04266940
42mannosylation (GO:0097502)3.03480814
43L-fucose metabolic process (GO:0042354)2.98256033
44L-fucose catabolic process (GO:0042355)2.98256033
45fucose catabolic process (GO:0019317)2.98256033
46cellular response to interferon-beta (GO:0035458)2.95477175
47piRNA metabolic process (GO:0034587)2.92939164
48behavioral response to nicotine (GO:0035095)2.91993855
49mast cell activation (GO:0045576)2.89381025
50regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.88970956
51protein complex biogenesis (GO:0070271)2.87291714
52negative regulation of heart rate (GO:0010459)2.83533756
53positive regulation of defense response to virus by host (GO:0002230)2.81991351
54regulation of isotype switching to IgG isotypes (GO:0048302)2.81698645
55regulation of prostaglandin secretion (GO:0032306)2.79474375
56respiratory chain complex IV assembly (GO:0008535)2.79282876
57positive regulation of fatty acid transport (GO:2000193)2.78764221
58negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.78376249
59positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.77539902
60viral transcription (GO:0019083)2.77159207
61proteasome assembly (GO:0043248)2.76648300
62aldehyde catabolic process (GO:0046185)2.76122909
63rRNA catabolic process (GO:0016075)2.74581289
64translational termination (GO:0006415)2.71607143
65S-adenosylmethionine metabolic process (GO:0046500)2.68476106
66tRNA processing (GO:0008033)2.68072309
67dopamine transport (GO:0015872)2.67328369
68aggressive behavior (GO:0002118)2.62772704
69regulation of cellular amino acid metabolic process (GO:0006521)2.61793931
70cytochrome complex assembly (GO:0017004)2.61379224
71aromatic amino acid family catabolic process (GO:0009074)2.61058375
72regulation of germinal center formation (GO:0002634)2.60317693
73mitochondrial respiratory chain complex assembly (GO:0033108)2.59956147
74translational elongation (GO:0006414)2.58172120
75amine catabolic process (GO:0009310)2.57921638
76cellular biogenic amine catabolic process (GO:0042402)2.57921638
77mast cell degranulation (GO:0043303)2.55840871
78mast cell activation involved in immune response (GO:0002279)2.55840871
79positive regulation of protein homodimerization activity (GO:0090073)2.55779454
80mitochondrial respiratory chain complex I assembly (GO:0032981)2.55636615
81NADH dehydrogenase complex assembly (GO:0010257)2.55636615
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55636615
83positive regulation of T cell mediated cytotoxicity (GO:0001916)2.55422230
84ubiquinone biosynthetic process (GO:0006744)2.55132345
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.54300847
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.54225859
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.52728352
88chaperone-mediated protein transport (GO:0072321)2.52414067
89regulation of regulatory T cell differentiation (GO:0045589)2.51806879
90ATP biosynthetic process (GO:0006754)2.50478848
91signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49430981
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49430981
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49430981
94rRNA processing (GO:0006364)2.48593905
95positive regulation of B cell mediated immunity (GO:0002714)2.48441249
96positive regulation of immunoglobulin mediated immune response (GO:0002891)2.48441249
97rRNA metabolic process (GO:0016072)2.46584084
98cotranslational protein targeting to membrane (GO:0006613)2.45903149
99GPI anchor metabolic process (GO:0006505)2.44304172
100protein targeting to ER (GO:0045047)2.44281788

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.87672746
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.87475763
3ELF1_17652178_ChIP-ChIP_JURKAT_Human3.48695052
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41969203
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.26718461
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.04718197
7ZNF274_21170338_ChIP-Seq_K562_Hela2.71554555
8VDR_22108803_ChIP-Seq_LS180_Human2.62550568
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.59647880
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.55149817
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52878286
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.38823214
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.38421209
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36083825
15VDR_23849224_ChIP-Seq_CD4+_Human2.34271123
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20157714
17IGF1R_20145208_ChIP-Seq_DFB_Human2.12322461
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.10317185
19ELK1_19687146_ChIP-ChIP_HELA_Human2.01270233
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98672749
21PCGF2_27294783_Chip-Seq_ESCs_Mouse1.97893877
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85041683
23FOXP3_21729870_ChIP-Seq_TREG_Human1.84508167
24SRF_21415370_ChIP-Seq_HL-1_Mouse1.79360710
25GATA3_26560356_Chip-Seq_TH2_Human1.75673482
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71048383
27TP53_22573176_ChIP-Seq_HFKS_Human1.67474430
28EWS_26573619_Chip-Seq_HEK293_Human1.64690351
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.63831855
30TAF15_26573619_Chip-Seq_HEK293_Human1.57932744
31IRF8_21731497_ChIP-ChIP_J774_Mouse1.56627624
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55068974
33FUS_26573619_Chip-Seq_HEK293_Human1.54278727
34AR_20517297_ChIP-Seq_VCAP_Human1.53433508
35MYC_18940864_ChIP-ChIP_HL60_Human1.48168689
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47991353
37ER_23166858_ChIP-Seq_MCF-7_Human1.45727469
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42589636
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.41966696
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41966696
41GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41102306
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38593746
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30198045
44NANOG_19829295_ChIP-Seq_ESCs_Human1.30161458
45SOX2_19829295_ChIP-Seq_ESCs_Human1.30161458
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.28312430
47IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27702076
48CBP_20019798_ChIP-Seq_JUKART_Human1.27702076
49FOXH1_21741376_ChIP-Seq_EPCs_Human1.27532034
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27168995
51MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26787499
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26558132
53ERG_20517297_ChIP-Seq_VCAP_Human1.25303086
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.24289230
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.23114880
56AUTS2_25519132_ChIP-Seq_293T-REX_Human1.22692288
57LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22647265
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17965030
59PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.17825549
60FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16338125
61P300_19829295_ChIP-Seq_ESCs_Human1.14715182
62NCOR_22424771_ChIP-Seq_293T_Human1.14528812
63NFE2_27457419_Chip-Seq_LIVER_Mouse1.13509653
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11817849
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10564571
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.09771956
67TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.09503743
68POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08691728
69EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08066079
70IRF1_19129219_ChIP-ChIP_H3396_Human1.07972460
71EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07767372
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.07656337
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.07483254
74GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.06908769
75HOXB7_26014856_ChIP-Seq_BT474_Human1.06644087
76TAF2_19829295_ChIP-Seq_ESCs_Human1.05339165
77NANOG_20526341_ChIP-Seq_ESCs_Human1.04670183
78CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04460710
79MYB_26560356_Chip-Seq_TH2_Human1.04232133
80FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01561152
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01477672
82TDRD3_21172665_ChIP-Seq_MCF-7_Human1.00801794
83MYC_19829295_ChIP-Seq_ESCs_Human1.00288453
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.99937481
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99562602
86CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99262925
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98788023
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98275234
89HOXB4_20404135_ChIP-ChIP_EML_Mouse0.96616840
90GATA3_26560356_Chip-Seq_TH1_Human0.96376063
91STAT1_20625510_ChIP-Seq_HELA_Human0.95736613
92GBX2_23144817_ChIP-Seq_PC3_Human0.95563799
93ERA_21632823_ChIP-Seq_H3396_Human0.95394105
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.95158496
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94837243
96KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94670128
97GATA3_27048872_Chip-Seq_THYMUS_Human0.94297284
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94230333
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94144709
100P53_21459846_ChIP-Seq_SAOS-2_Human0.93932602

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.52815962
2MP0005671_abnormal_response_to3.52664831
3MP0008875_abnormal_xenobiotic_pharmacok3.20704336
4MP0002138_abnormal_hepatobiliary_system2.71347387
5MP0008877_abnormal_DNA_methylation2.67784805
6MP0008872_abnormal_physiological_respon2.61568074
7MP0003806_abnormal_nucleotide_metabolis2.59665172
8MP0001968_abnormal_touch/_nociception2.42663995
9MP0009379_abnormal_foot_pigmentation2.24431624
10MP0000685_abnormal_immune_system2.18872160
11MP0003195_calcinosis2.10916036
12MP0006292_abnormal_olfactory_placode2.07456260
13MP0002148_abnormal_hypersensitivity_rea2.05512977
14MP0002837_dystrophic_cardiac_calcinosis1.92745211
15MP0003724_increased_susceptibility_to1.91584200
16MP0002736_abnormal_nociception_after1.91543828
17MP0004147_increased_porphyrin_level1.89951226
18MP0001800_abnormal_humoral_immune1.84583136
19MP0005075_abnormal_melanosome_morpholog1.82134757
20MP0001986_abnormal_taste_sensitivity1.80804018
21MP0002876_abnormal_thyroid_physiology1.79516188
22MP0002006_tumorigenesis1.78014997
23MP0009785_altered_susceptibility_to1.75344504
24MP0003646_muscle_fatigue1.74834989
25MP0000372_irregular_coat_pigmentation1.73508221
26MP0005645_abnormal_hypothalamus_physiol1.73396214
27MP0008058_abnormal_DNA_repair1.72367794
28MP0002102_abnormal_ear_morphology1.69464811
29MP0002166_altered_tumor_susceptibility1.67888359
30MP0005000_abnormal_immune_tolerance1.62540743
31MP0005646_abnormal_pituitary_gland1.57843065
32MP0005551_abnormal_eye_electrophysiolog1.57402898
33MP0005084_abnormal_gallbladder_morpholo1.56484748
34MP0006072_abnormal_retinal_apoptosis1.55071965
35MP0004885_abnormal_endolymph1.49955029
36MP0008775_abnormal_heart_ventricle1.45470636
37MP0009764_decreased_sensitivity_to1.42724834
38MP0002234_abnormal_pharynx_morphology1.37867794
39MP0002723_abnormal_immune_serum1.37309216
40MP0003252_abnormal_bile_duct1.36885729
41MP0005389_reproductive_system_phenotype1.33955665
42MP0004142_abnormal_muscle_tone1.33824757
43MP0002452_abnormal_antigen_presenting1.31794633
44MP0005085_abnormal_gallbladder_physiolo1.31599894
45MP0003011_delayed_dark_adaptation1.30745454
46MP0009333_abnormal_splenocyte_physiolog1.26468441
47MP0006036_abnormal_mitochondrial_physio1.24803675
48MP0005167_abnormal_blood-brain_barrier1.23573964
49MP0002420_abnormal_adaptive_immunity1.23397600
50MP0005387_immune_system_phenotype1.22454570
51MP0001790_abnormal_immune_system1.22454570
52MP0001819_abnormal_immune_cell1.22416649
53MP0010155_abnormal_intestine_physiology1.19977627
54MP0001919_abnormal_reproductive_system1.17964058
55MP0002160_abnormal_reproductive_system1.17736523
56MP0003763_abnormal_thymus_physiology1.17018900
57MP0003718_maternal_effect1.15244451
58MP0004145_abnormal_muscle_electrophysio1.14408593
59MP0002095_abnormal_skin_pigmentation1.12606472
60MP0003186_abnormal_redox_activity1.08660492
61MP0003787_abnormal_imprinting1.07604078
62MP0003866_abnormal_defecation1.06928624
63MP0001905_abnormal_dopamine_level1.05021350
64MP0003436_decreased_susceptibility_to1.02804491
65MP0005410_abnormal_fertilization1.02002185
66MP0008995_early_reproductive_senescence1.00537660
67MP0001845_abnormal_inflammatory_respons0.97564986
68MP0000427_abnormal_hair_cycle0.97488784
69MP0001873_stomach_inflammation0.97402308
70MP0009697_abnormal_copulation0.96356628
71MP0006035_abnormal_mitochondrial_morpho0.96320383
72MP0001501_abnormal_sleep_pattern0.96152607
73MP0000383_abnormal_hair_follicle0.95591488
74MP0006276_abnormal_autonomic_nervous0.95057534
75MP0003786_premature_aging0.93516029
76MP0000716_abnormal_immune_system0.93505870
77MP0005025_abnormal_response_to0.91022198
78MP0002398_abnormal_bone_marrow0.88370231
79MP0001853_heart_inflammation0.87657892
80MP0001764_abnormal_homeostasis0.87565853
81MP0002277_abnormal_respiratory_mucosa0.87267502
82MP0002272_abnormal_nervous_system0.86956389
83MP0000689_abnormal_spleen_morphology0.86379870
84MP0004043_abnormal_pH_regulation0.86309480
85MP0009046_muscle_twitch0.85726638
86MP0005253_abnormal_eye_physiology0.85627492
87MP0000230_abnormal_systemic_arterial0.85018277
88MP0005636_abnormal_mineral_homeostasis0.84426358
89MP0000516_abnormal_urinary_system0.84232505
90MP0005367_renal/urinary_system_phenotyp0.84232505
91MP0009745_abnormal_behavioral_response0.81436719
92MP0002735_abnormal_chemical_nociception0.80285251
93MP0006054_spinal_hemorrhage0.78604710
94MP0009643_abnormal_urine_homeostasis0.78179737
95MP0008469_abnormal_protein_level0.76829749
96MP0002733_abnormal_thermal_nociception0.76077752
97MP0002429_abnormal_blood_cell0.74689522
98MP0001970_abnormal_pain_threshold0.74047399
99MP0001881_abnormal_mammary_gland0.73831077
100MP0002419_abnormal_innate_immunity0.73580321

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)3.79330491
23-Methylglutaconic aciduria (HP:0003535)3.78685679
3Pancreatic cysts (HP:0001737)3.56469055
4Abnormal biliary tract physiology (HP:0012439)3.50600453
5Bile duct proliferation (HP:0001408)3.50600453
6Abnormality of B cell number (HP:0010975)3.44855592
7Increased CSF lactate (HP:0002490)3.44498109
8Mitochondrial inheritance (HP:0001427)3.44487725
9Congenital, generalized hypertrichosis (HP:0004540)3.40647413
10Acute necrotizing encephalopathy (HP:0006965)3.29832537
11IgG deficiency (HP:0004315)3.29470957
12Abnormality of the prostate (HP:0008775)3.17190369
13Increased hepatocellular lipid droplets (HP:0006565)3.16493355
14Pancreatic fibrosis (HP:0100732)3.15297529
15Lipid accumulation in hepatocytes (HP:0006561)3.13597027
16Elevated erythrocyte sedimentation rate (HP:0003565)3.09492209
17Type 2 muscle fiber atrophy (HP:0003554)3.08680901
18Acute encephalopathy (HP:0006846)3.04462478
19Stomatitis (HP:0010280)3.04374337
20Methylmalonic acidemia (HP:0002912)3.01690558
21Progressive macrocephaly (HP:0004481)2.95411466
22Hepatocellular necrosis (HP:0001404)2.90529590
23Testicular atrophy (HP:0000029)2.87580755
24Stomach cancer (HP:0012126)2.76998074
25Abnormal mitochondria in muscle tissue (HP:0008316)2.76892228
26Nephronophthisis (HP:0000090)2.76620995
27True hermaphroditism (HP:0010459)2.76450654
28Hepatic necrosis (HP:0002605)2.71865431
29Abolished electroretinogram (ERG) (HP:0000550)2.70566142
30Abnormality of the renal cortex (HP:0011035)2.69229033
31Abnormal rod and cone electroretinograms (HP:0008323)2.65824122
32Type II lissencephaly (HP:0007260)2.61733272
33Attenuation of retinal blood vessels (HP:0007843)2.61645960
34Molar tooth sign on MRI (HP:0002419)2.58151925
35Abnormality of midbrain morphology (HP:0002418)2.58151925
36Decreased central vision (HP:0007663)2.57643920
37Prostate neoplasm (HP:0100787)2.55974712
38Abnormality of the renal medulla (HP:0100957)2.55971641
39Colon cancer (HP:0003003)2.52843046
40Increased serum lactate (HP:0002151)2.51458319
41Autoimmune hemolytic anemia (HP:0001890)2.51114099
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49647259
43Muscle fiber atrophy (HP:0100295)2.46962526
44Hypoproteinemia (HP:0003075)2.44743863
45Decreased electroretinogram (ERG) amplitude (HP:0000654)2.43738898
46B lymphocytopenia (HP:0010976)2.43111342
47Renal Fanconi syndrome (HP:0001994)2.42810323
48Methylmalonic aciduria (HP:0012120)2.41756837
49Panhypogammaglobulinemia (HP:0003139)2.41051163
50Abnormality of T cell physiology (HP:0011840)2.40002741
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39631243
52Optic disc pallor (HP:0000543)2.34134352
53Autoimmune thrombocytopenia (HP:0001973)2.33203526
54Aplasia/Hypoplasia of the spleen (HP:0010451)2.29099261
55Thyroiditis (HP:0100646)2.28084018
56Asplenia (HP:0001746)2.27101046
57Lactic acidosis (HP:0003128)2.22075786
58Polydipsia (HP:0001959)2.17980313
59Abnormal drinking behavior (HP:0030082)2.17980313
60Cerebral edema (HP:0002181)2.17973257
61Severe combined immunodeficiency (HP:0004430)2.14442816
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.13896844
63Cystic liver disease (HP:0006706)2.12246922
64Pendular nystagmus (HP:0012043)2.11098413
65Renal cortical cysts (HP:0000803)2.10655868
66Abnormality of cells of the erythroid lineage (HP:0012130)2.10051881
67Abnormality of T cells (HP:0002843)2.07868979
68Exertional dyspnea (HP:0002875)2.06143204
69Sclerocornea (HP:0000647)2.04257492
70Type I transferrin isoform profile (HP:0003642)2.03549816
71Lethargy (HP:0001254)2.00335469
72Reticulocytopenia (HP:0001896)1.95511463
73Increased intramyocellular lipid droplets (HP:0012240)1.94919795
74Dicarboxylic aciduria (HP:0003215)1.94826466
75Abnormality of dicarboxylic acid metabolism (HP:0010995)1.94826466
76Tubular atrophy (HP:0000092)1.94085513
77Abnormal number of erythroid precursors (HP:0012131)1.93865676
78Pancytopenia (HP:0001876)1.91654964
79Abnormal delayed hypersensitivity skin test (HP:0002963)1.89995162
80Azoospermia (HP:0000027)1.89604615
81Keratoconus (HP:0000563)1.88725649
82Increased corneal curvature (HP:0100692)1.88725649
83Oral leukoplakia (HP:0002745)1.85281999
84Dynein arm defect of respiratory motile cilia (HP:0012255)1.85210972
85Absent/shortened dynein arms (HP:0200106)1.85210972
86Abnormal spermatogenesis (HP:0008669)1.84752782
87Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.84375623
88Abnormality of male internal genitalia (HP:0000022)1.83660651
89Polyuria (HP:0000103)1.82067518
90Delayed CNS myelination (HP:0002188)1.81140687
91Aplastic anemia (HP:0001915)1.80459502
92Abnormality of the vitamin B12 metabolism (HP:0004341)1.77867221
93Hypokalemic alkalosis (HP:0001949)1.76631097
94Agammaglobulinemia (HP:0004432)1.76225077
95Erythroderma (HP:0001019)1.76206102
96Respiratory failure (HP:0002878)1.75642760
97Dyschromatopsia (HP:0007641)1.73930553
98Increased IgM level (HP:0003496)1.72766410
99Chronic hepatic failure (HP:0100626)1.71819651
100Male pseudohermaphroditism (HP:0000037)1.71478997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.05560678
2TAOK33.83188392
3TLK13.41262099
4NUAK13.16132779
5FRK3.03579121
6ZAK2.95864690
7TXK2.73842806
8ADRBK22.72725995
9VRK22.65979278
10PINK12.38202294
11GRK12.26671422
12EIF2AK32.16924274
13STK161.97996662
14CDK191.90223861
15MST41.76923118
16TEC1.53907480
17KIT1.48640983
18BCKDK1.40685642
19PHKG21.37831055
20PHKG11.37831055
21TIE11.35733193
22MUSK1.35371686
23OXSR11.35357606
24EIF2AK11.34912027
25MAP3K121.34456102
26VRK11.33219110
27MKNK11.29611481
28ITK1.27830016
29BMPR21.24993433
30FES1.17606328
31DAPK21.12195564
32IKBKB1.11502848
33PASK1.10458371
34SRPK11.09954139
35GRK61.08406004
36PLK21.06879595
37WNK41.04840771
38TAF11.04382424
39MAP3K141.01082024
40MAP4K11.00994202
41EIF2AK20.98594340
42CAMKK20.97285163
43BTK0.96434327
44PIK3CG0.95452633
45BMPR1B0.90572885
46MAPKAPK50.89805776
47SYK0.88477339
48INSRR0.87802427
49DAPK10.80827522
50ERBB30.77389484
51MYLK0.76985558
52MKNK20.74861355
53ADRBK10.74474954
54MAP2K60.74330061
55TRPM70.74308020
56RPS6KA50.73939810
57PRKCQ0.73341932
58PIK3CA0.71176846
59PLK40.70237870
60WNK30.70135263
61FLT30.69632447
62DYRK20.69311977
63PLK30.68036331
64LCK0.63638596
65LYN0.62558083
66CSNK1G30.61591964
67IKBKE0.61589567
68MAPKAPK30.60740105
69TRIM280.55685317
70STK390.55597925
71CAMKK10.53864257
72JAK30.50998491
73IGF1R0.50476160
74CSNK1A1L0.48328575
75PDK20.48157125
76KDR0.46085673
77MAPK130.45585321
78NME20.45541961
79PIM20.44070440
80GRK50.43383555
81NEK10.43131388
82OBSCN0.42909615
83CSNK1G10.42901424
84CSF1R0.41512559
85MAP3K130.39842433
86DAPK30.39698302
87GRK70.39125524
88TSSK60.38663828
89PRKCE0.37327025
90HCK0.37104036
91NME10.36605572
92CSNK1G20.35497235
93PRKCA0.35494776
94CSNK1A10.35305108
95TNK20.35049042
96TGFBR10.34929771
97CDC70.34816177
98PTK2B0.32172892
99ABL10.32083876
100CHUK0.31529281

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.44575998
2Intestinal immune network for IgA production_Homo sapiens_hsa046723.53594225
3Allograft rejection_Homo sapiens_hsa053303.52429840
4Autoimmune thyroid disease_Homo sapiens_hsa053203.32324562
5Proteasome_Homo sapiens_hsa030503.06236916
6Graft-versus-host disease_Homo sapiens_hsa053322.90944026
7Ribosome_Homo sapiens_hsa030102.70139781
8Oxidative phosphorylation_Homo sapiens_hsa001902.69296732
9Type I diabetes mellitus_Homo sapiens_hsa049402.68882153
10Caffeine metabolism_Homo sapiens_hsa002322.67245898
11Parkinsons disease_Homo sapiens_hsa050122.11879725
12RNA polymerase_Homo sapiens_hsa030202.06644751
13One carbon pool by folate_Homo sapiens_hsa006701.98507256
14Homologous recombination_Homo sapiens_hsa034401.96396812
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.88159017
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.84970754
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.78398090
18Primary immunodeficiency_Homo sapiens_hsa053401.75265214
19Phototransduction_Homo sapiens_hsa047441.69558295
20Nitrogen metabolism_Homo sapiens_hsa009101.60886553
21Antigen processing and presentation_Homo sapiens_hsa046121.59630457
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57347864
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56700634
24Linoleic acid metabolism_Homo sapiens_hsa005911.54218404
25Rheumatoid arthritis_Homo sapiens_hsa053231.53607470
26Protein export_Homo sapiens_hsa030601.47214349
27RNA degradation_Homo sapiens_hsa030181.40011104
28Alzheimers disease_Homo sapiens_hsa050101.34653027
29Tryptophan metabolism_Homo sapiens_hsa003801.29061001
30Basal transcription factors_Homo sapiens_hsa030221.24849353
31Staphylococcus aureus infection_Homo sapiens_hsa051501.18642722
32Huntingtons disease_Homo sapiens_hsa050161.17035842
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13628942
34Fanconi anemia pathway_Homo sapiens_hsa034601.09399318
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.08061162
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.04628047
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03504003
38Chemical carcinogenesis_Homo sapiens_hsa052041.00071824
39Propanoate metabolism_Homo sapiens_hsa006400.99939016
40Cardiac muscle contraction_Homo sapiens_hsa042600.99570029
41Viral myocarditis_Homo sapiens_hsa054160.97559084
42Hematopoietic cell lineage_Homo sapiens_hsa046400.92482267
43Systemic lupus erythematosus_Homo sapiens_hsa053220.90730660
44Leishmaniasis_Homo sapiens_hsa051400.86284643
45Purine metabolism_Homo sapiens_hsa002300.85507188
46Pyrimidine metabolism_Homo sapiens_hsa002400.85497898
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.85381264
48Arachidonic acid metabolism_Homo sapiens_hsa005900.85336207
49Mismatch repair_Homo sapiens_hsa034300.82870295
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79974395
51Sulfur metabolism_Homo sapiens_hsa009200.78801937
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78646215
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77358176
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75527166
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.74481816
56RNA transport_Homo sapiens_hsa030130.72229037
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.70747008
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.69984906
59Butanoate metabolism_Homo sapiens_hsa006500.68851557
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.66753147
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65875808
62Retinol metabolism_Homo sapiens_hsa008300.64681228
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64393526
64Ether lipid metabolism_Homo sapiens_hsa005650.63147905
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.62004080
66Non-homologous end-joining_Homo sapiens_hsa034500.61540929
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58368633
68Peroxisome_Homo sapiens_hsa041460.57922395
69Olfactory transduction_Homo sapiens_hsa047400.57458973
70Spliceosome_Homo sapiens_hsa030400.54853125
71Nucleotide excision repair_Homo sapiens_hsa034200.53124489
72Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53048014
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.52567395
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50957461
75Metabolic pathways_Homo sapiens_hsa011000.50887366
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.48784422
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45366132
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39919731
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.39406300
80Herpes simplex infection_Homo sapiens_hsa051680.38992447
81Primary bile acid biosynthesis_Homo sapiens_hsa001200.38931764
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37262296
83T cell receptor signaling pathway_Homo sapiens_hsa046600.36853707
84Fat digestion and absorption_Homo sapiens_hsa049750.36104531
85Salivary secretion_Homo sapiens_hsa049700.35932928
86Selenocompound metabolism_Homo sapiens_hsa004500.35523780
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.35179884
88Fatty acid elongation_Homo sapiens_hsa000620.34421467
89DNA replication_Homo sapiens_hsa030300.32905410
90Ovarian steroidogenesis_Homo sapiens_hsa049130.31174986
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30389573
92RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29857609
93Fatty acid degradation_Homo sapiens_hsa000710.28619049
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28591103
95Base excision repair_Homo sapiens_hsa034100.28316348
96Collecting duct acid secretion_Homo sapiens_hsa049660.28101339
97Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28081721
98Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27983183
99Maturity onset diabetes of the young_Homo sapiens_hsa049500.27380558
100Epstein-Barr virus infection_Homo sapiens_hsa051690.26626268

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