RPL7P15

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.38991134
2DNA deamination (GO:0045006)4.99335973
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.73149173
4ATP synthesis coupled proton transport (GO:0015986)4.73149173
5mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51110652
6ribosomal large subunit biogenesis (GO:0042273)4.41096898
7viral transcription (GO:0019083)4.16264204
8translational termination (GO:0006415)4.02765251
9response to pheromone (GO:0019236)4.00718136
10kynurenine metabolic process (GO:0070189)3.83908818
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.68997275
12maturation of SSU-rRNA (GO:0030490)3.67939791
13translational elongation (GO:0006414)3.67009301
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.63043421
15cotranslational protein targeting to membrane (GO:0006613)3.60398110
16protein targeting to ER (GO:0045047)3.58076753
17nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.57483609
18behavioral response to nicotine (GO:0035095)3.55951251
19indole-containing compound catabolic process (GO:0042436)3.52156704
20indolalkylamine catabolic process (GO:0046218)3.52156704
21tryptophan catabolic process (GO:0006569)3.52156704
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.46802826
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.46802826
24exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44181600
25protein localization to endoplasmic reticulum (GO:0070972)3.42992008
26water-soluble vitamin biosynthetic process (GO:0042364)3.41476226
27establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40752578
28negative regulation of heart rate (GO:0010459)3.37410060
29positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.33410245
30electron transport chain (GO:0022900)3.28491768
31respiratory electron transport chain (GO:0022904)3.25130997
32regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.23702895
33negative regulation of mast cell activation (GO:0033004)3.22598903
34respiratory chain complex IV assembly (GO:0008535)3.13153342
35detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.12921236
36protein neddylation (GO:0045116)3.09607930
37establishment of protein localization to mitochondrial membrane (GO:0090151)3.09046384
38cellular ketone body metabolic process (GO:0046950)3.07015061
39protein complex biogenesis (GO:0070271)3.06427296
40regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.03849277
41preassembly of GPI anchor in ER membrane (GO:0016254)3.01006659
42GPI anchor biosynthetic process (GO:0006506)2.98490301
43GPI anchor metabolic process (GO:0006505)2.97347693
44indolalkylamine metabolic process (GO:0006586)2.97074303
45cytidine metabolic process (GO:0046087)2.94309301
46cytidine catabolic process (GO:0006216)2.94309301
47cytidine deamination (GO:0009972)2.94309301
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.93697361
49mitochondrial respiratory chain complex I assembly (GO:0032981)2.93697361
50NADH dehydrogenase complex assembly (GO:0010257)2.93697361
51platelet dense granule organization (GO:0060155)2.93401087
52translation (GO:0006412)2.92974387
53translational initiation (GO:0006413)2.91959771
54positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.90885017
55viral life cycle (GO:0019058)2.90550518
56positive regulation of protein homodimerization activity (GO:0090073)2.89197616
57tryptophan metabolic process (GO:0006568)2.88695823
58cytochrome complex assembly (GO:0017004)2.88088929
59cellular protein complex disassembly (GO:0043624)2.86956011
60RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80331907
61ketone body metabolic process (GO:1902224)2.78962252
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78364797
63mitochondrial respiratory chain complex assembly (GO:0033108)2.74507735
64hydrogen ion transmembrane transport (GO:1902600)2.73814284
65ATP biosynthetic process (GO:0006754)2.73446382
66rRNA modification (GO:0000154)2.70737363
67regulation of hypersensitivity (GO:0002883)2.70583564
68purine nucleoside triphosphate biosynthetic process (GO:0009145)2.68710036
69purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.66942066
70piRNA metabolic process (GO:0034587)2.66839951
71base-excision repair, AP site formation (GO:0006285)2.64989344
72chaperone-mediated protein transport (GO:0072321)2.63539681
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.62152698
74axoneme assembly (GO:0035082)2.59782690
75mast cell activation (GO:0045576)2.59422788
76proton transport (GO:0015992)2.58766483
77aldehyde catabolic process (GO:0046185)2.55986862
78hydrogen transport (GO:0006818)2.54505640
79proteasome assembly (GO:0043248)2.53954026
80negative regulation of T cell differentiation in thymus (GO:0033085)2.53929783
81positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.53289000
82protein-cofactor linkage (GO:0018065)2.51731777
83detection of light stimulus involved in sensory perception (GO:0050962)2.51347574
84detection of light stimulus involved in visual perception (GO:0050908)2.51347574
85ribosomal small subunit biogenesis (GO:0042274)2.50158018
86regulation of cellular amino acid metabolic process (GO:0006521)2.47373522
87regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.46547402
88negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.46401942
89GTP biosynthetic process (GO:0006183)2.46345066
90pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.45024592
91regulation of immunoglobulin secretion (GO:0051023)2.42572867
92epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42133997
93mannosylation (GO:0097502)2.39147213
94S-adenosylmethionine metabolic process (GO:0046500)2.38645349
95nuclear-transcribed mRNA catabolic process (GO:0000956)2.37499787
96regulation of isotype switching to IgG isotypes (GO:0048302)2.37199142
97ubiquinone biosynthetic process (GO:0006744)2.37182294
98regulation of cilium movement (GO:0003352)2.36894094
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.36079229
100L-methionine biosynthetic process (GO:0071265)2.35922066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.90501153
2GABP_17652178_ChIP-ChIP_JURKAT_Human3.23089640
3VDR_22108803_ChIP-Seq_LS180_Human3.16809328
4ZNF274_21170338_ChIP-Seq_K562_Hela2.95347235
5EZH2_22144423_ChIP-Seq_EOC_Human2.76393512
6HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.68856892
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65169503
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.64277492
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.57242453
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.48741489
11IGF1R_20145208_ChIP-Seq_DFB_Human2.46820633
12VDR_23849224_ChIP-Seq_CD4+_Human2.21069528
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.16342680
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.12832981
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.10291887
16PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07729711
17EWS_26573619_Chip-Seq_HEK293_Human2.06681677
18FUS_26573619_Chip-Seq_HEK293_Human1.93771200
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91464424
20ELK1_19687146_ChIP-ChIP_HELA_Human1.84647051
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80808405
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.79504438
23EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.79415539
24PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74998343
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.73331446
26ER_23166858_ChIP-Seq_MCF-7_Human1.72211396
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71190414
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.70579695
29TP53_22573176_ChIP-Seq_HFKS_Human1.70017765
30TAF15_26573619_Chip-Seq_HEK293_Human1.68551794
31FOXA1_27270436_Chip-Seq_PROSTATE_Human1.62932895
32FOXA1_25329375_ChIP-Seq_VCAP_Human1.62932895
33FOXP3_21729870_ChIP-Seq_TREG_Human1.57112508
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56014668
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55828923
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.55663135
37AR_20517297_ChIP-Seq_VCAP_Human1.54137433
38MYC_18940864_ChIP-ChIP_HL60_Human1.51563194
39GBX2_23144817_ChIP-Seq_PC3_Human1.50233249
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49627528
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.49161120
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.47716888
43CBP_20019798_ChIP-Seq_JUKART_Human1.46823121
44IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46823121
45IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45792226
46AUTS2_25519132_ChIP-Seq_293T-REX_Human1.44238561
47SOX2_19829295_ChIP-Seq_ESCs_Human1.40686600
48NANOG_19829295_ChIP-Seq_ESCs_Human1.40686600
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38754809
50GATA3_26560356_Chip-Seq_TH2_Human1.37950670
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34550952
52MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33637005
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33270523
54P300_19829295_ChIP-Seq_ESCs_Human1.33047609
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30938508
56FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30363311
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.28755923
58NFE2_27457419_Chip-Seq_LIVER_Mouse1.26231581
59GATA3_21878914_ChIP-Seq_MCF-7_Human1.24057622
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.22228669
61NCOR_22424771_ChIP-Seq_293T_Human1.21033132
62NOTCH1_21737748_ChIP-Seq_TLL_Human1.20719744
63IRF1_19129219_ChIP-ChIP_H3396_Human1.20494700
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19777492
65ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19663226
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.18894325
67TAF2_19829295_ChIP-Seq_ESCs_Human1.16890909
68NANOG_20526341_ChIP-Seq_ESCs_Human1.14977257
69FOXH1_21741376_ChIP-Seq_EPCs_Human1.12527748
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12166015
71CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.12056972
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10644671
73ERG_20517297_ChIP-Seq_VCAP_Human1.09798081
74MYC_18555785_ChIP-Seq_MESCs_Mouse1.09416696
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.08599084
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08568961
77GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06673422
78HOXB7_26014856_ChIP-Seq_BT474_Human1.06142625
79MYB_26560356_Chip-Seq_TH2_Human1.03912674
80TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02572988
81TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02282264
82TCF4_22108803_ChIP-Seq_LS180_Human1.01224096
83EGR1_23403033_ChIP-Seq_LIVER_Mouse1.01030349
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.00159139
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.99014791
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98488415
87GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.98151551
88LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97818718
89CRX_20693478_ChIP-Seq_RETINA_Mouse0.96391537
90BCAT_22108803_ChIP-Seq_LS180_Human0.95105901
91PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91346454
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90844675
93GATA3_26560356_Chip-Seq_TH1_Human0.89690550
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.89173025
95ERA_21632823_ChIP-Seq_H3396_Human0.89063082
96MYC_19829295_ChIP-Seq_ESCs_Human0.88668530
97FOXH1_21741376_ChIP-Seq_ESCs_Human0.88494413
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88333284
99MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88124846
100POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88042273

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation3.49233198
2MP0006292_abnormal_olfactory_placode3.21891734
3MP0001835_abnormal_antigen_presentation3.09200773
4MP0005671_abnormal_response_to3.04338406
5MP0008875_abnormal_xenobiotic_pharmacok2.97968010
6MP0008877_abnormal_DNA_methylation2.32262519
7MP0008872_abnormal_physiological_respon2.27428052
8MP0002102_abnormal_ear_morphology2.27377441
9MP0003646_muscle_fatigue2.27063817
10MP0004147_increased_porphyrin_level2.21914647
11MP0005645_abnormal_hypothalamus_physiol2.21904534
12MP0002837_dystrophic_cardiac_calcinosis2.15804532
13MP0005646_abnormal_pituitary_gland2.12966136
14MP0005551_abnormal_eye_electrophysiolog1.97735190
15MP0006072_abnormal_retinal_apoptosis1.96955514
16MP0002163_abnormal_gland_morphology1.89735740
17MP0001986_abnormal_taste_sensitivity1.88441256
18MP0001968_abnormal_touch/_nociception1.81678329
19MP0002166_altered_tumor_susceptibility1.78867380
20MP0002736_abnormal_nociception_after1.73618870
21MP0001800_abnormal_humoral_immune1.72802294
22MP0002138_abnormal_hepatobiliary_system1.67447474
23MP0002148_abnormal_hypersensitivity_rea1.67384569
24MP0005075_abnormal_melanosome_morpholog1.66862661
25MP0002876_abnormal_thyroid_physiology1.66487257
26MP0009785_altered_susceptibility_to1.64815922
27MP0005084_abnormal_gallbladder_morpholo1.64495140
28MP0000372_irregular_coat_pigmentation1.55179682
29MP0004885_abnormal_endolymph1.54020674
30MP0004142_abnormal_muscle_tone1.51204783
31MP0009764_decreased_sensitivity_to1.48404306
32MP0005389_reproductive_system_phenotype1.46599971
33MP0002006_tumorigenesis1.46267084
34MP0003195_calcinosis1.46258474
35MP0000685_abnormal_immune_system1.39097520
36MP0005000_abnormal_immune_tolerance1.36427702
37MP0005253_abnormal_eye_physiology1.36249755
38MP0002160_abnormal_reproductive_system1.33926184
39MP0002272_abnormal_nervous_system1.32675205
40MP0009333_abnormal_splenocyte_physiolog1.32356128
41MP0001873_stomach_inflammation1.31449492
42MP0003724_increased_susceptibility_to1.28283176
43MP0001919_abnormal_reproductive_system1.27465689
44MP0001905_abnormal_dopamine_level1.26858052
45MP0002723_abnormal_immune_serum1.25018515
46MP0001764_abnormal_homeostasis1.24324722
47MP0008789_abnormal_olfactory_epithelium1.20563860
48MP0001501_abnormal_sleep_pattern1.20064796
49MP0008995_early_reproductive_senescence1.18617579
50MP0002452_abnormal_antigen_presenting1.12540817
51MP0002234_abnormal_pharynx_morphology1.11124162
52MP0006276_abnormal_autonomic_nervous1.09416541
53MP0003866_abnormal_defecation1.08176468
54MP0003252_abnormal_bile_duct1.07585928
55MP0008058_abnormal_DNA_repair1.07322697
56MP0003011_delayed_dark_adaptation1.06995339
57MP0002420_abnormal_adaptive_immunity1.06240796
58MP0001819_abnormal_immune_cell1.04416388
59MP0001486_abnormal_startle_reflex1.01996507
60MP0009046_muscle_twitch1.01935936
61MP0005379_endocrine/exocrine_gland_phen1.01706288
62MP0005085_abnormal_gallbladder_physiolo1.01632384
63MP0003763_abnormal_thymus_physiology0.99178384
64MP0001790_abnormal_immune_system0.98949469
65MP0005387_immune_system_phenotype0.98949469
66MP0004145_abnormal_muscle_electrophysio0.97699099
67MP0003787_abnormal_imprinting0.97039506
68MP0005377_hearing/vestibular/ear_phenot0.96853057
69MP0003878_abnormal_ear_physiology0.96853057
70MP0008775_abnormal_heart_ventricle0.96302221
71MP0009745_abnormal_behavioral_response0.96078244
72MP0010155_abnormal_intestine_physiology0.95079412
73MP0002095_abnormal_skin_pigmentation0.94781799
74MP0000427_abnormal_hair_cycle0.94338243
75MP0001485_abnormal_pinna_reflex0.94000434
76MP0010386_abnormal_urinary_bladder0.93892948
77MP0001529_abnormal_vocalization0.91008051
78MP0002638_abnormal_pupillary_reflex0.88019075
79MP0001970_abnormal_pain_threshold0.87938479
80MP0003718_maternal_effect0.86406331
81MP0003786_premature_aging0.85627144
82MP0003283_abnormal_digestive_organ0.85548540
83MP0005174_abnormal_tail_pigmentation0.83350636
84MP0004043_abnormal_pH_regulation0.82760347
85MP0005167_abnormal_blood-brain_barrier0.81963561
86MP0005636_abnormal_mineral_homeostasis0.81585457
87MP0001984_abnormal_olfaction0.80982004
88MP0000631_abnormal_neuroendocrine_gland0.80921871
89MP0002277_abnormal_respiratory_mucosa0.80749633
90MP0005025_abnormal_response_to0.79568320
91MP0003436_decreased_susceptibility_to0.77854807
92MP0000716_abnormal_immune_system0.77100052
93MP0001440_abnormal_grooming_behavior0.76058421
94MP0005195_abnormal_posterior_eye0.75041255
95MP0003880_abnormal_central_pattern0.74995628
96MP0003186_abnormal_redox_activity0.74538974
97MP0001963_abnormal_hearing_physiology0.73998603
98MP0001845_abnormal_inflammatory_respons0.73935166
99MP0002733_abnormal_thermal_nociception0.73503243
100MP0002398_abnormal_bone_marrow0.72311862

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.24494187
2Acute necrotizing encephalopathy (HP:0006965)3.76841485
3Mitochondrial inheritance (HP:0001427)3.66360183
4Increased CSF lactate (HP:0002490)3.40906339
5Acute encephalopathy (HP:0006846)3.40147909
6Progressive macrocephaly (HP:0004481)3.29477527
7Hepatocellular necrosis (HP:0001404)3.27482500
8Abnormal mitochondria in muscle tissue (HP:0008316)3.13877913
9Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12095690
10Abnormal rod and cone electroretinograms (HP:0008323)3.10751331
11Congenital, generalized hypertrichosis (HP:0004540)3.08408232
12Decreased central vision (HP:0007663)3.00172115
13Pancreatic cysts (HP:0001737)2.95554101
14Elevated erythrocyte sedimentation rate (HP:0003565)2.93795925
15IgG deficiency (HP:0004315)2.92965981
16Aplastic anemia (HP:0001915)2.91220447
17Abnormality of cells of the erythroid lineage (HP:0012130)2.89863658
183-Methylglutaconic aciduria (HP:0003535)2.89106814
19Type II lissencephaly (HP:0007260)2.87843874
20Abnormality of midbrain morphology (HP:0002418)2.85555094
21Molar tooth sign on MRI (HP:0002419)2.85555094
22Abolished electroretinogram (ERG) (HP:0000550)2.84519859
23Hepatic necrosis (HP:0002605)2.84397604
24Absent/shortened dynein arms (HP:0200106)2.80438061
25Dynein arm defect of respiratory motile cilia (HP:0012255)2.80438061
26Increased hepatocellular lipid droplets (HP:0006565)2.76452072
27Attenuation of retinal blood vessels (HP:0007843)2.64274723
28Lipid accumulation in hepatocytes (HP:0006561)2.60487085
29Medial flaring of the eyebrow (HP:0010747)2.58883861
30Hypoproteinemia (HP:0003075)2.58151332
31Abnormal number of erythroid precursors (HP:0012131)2.55807607
32Abnormality of the prostate (HP:0008775)2.54322017
33Stomatitis (HP:0010280)2.51732208
34Pancreatic fibrosis (HP:0100732)2.48864053
35Type 2 muscle fiber atrophy (HP:0003554)2.47752943
36Nephronophthisis (HP:0000090)2.46925130
37Optic disc pallor (HP:0000543)2.46424535
38Methylmalonic acidemia (HP:0002912)2.45281136
39Cerebral edema (HP:0002181)2.44050303
40True hermaphroditism (HP:0010459)2.43912472
41Abnormality of the renal cortex (HP:0011035)2.40457063
42Hyperglycinemia (HP:0002154)2.38796485
43Aplasia/Hypoplasia of the spleen (HP:0010451)2.29900119
44Abnormality of alanine metabolism (HP:0010916)2.27551270
45Hyperalaninemia (HP:0003348)2.27551270
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27551270
47Asplenia (HP:0001746)2.27049150
48Macrocytic anemia (HP:0001972)2.26251070
49Pendular nystagmus (HP:0012043)2.26124208
50Abnormal respiratory epithelium morphology (HP:0012253)2.23752183
51Abnormal respiratory motile cilium morphology (HP:0005938)2.23752183
52Reticulocytopenia (HP:0001896)2.23485065
53Testicular atrophy (HP:0000029)2.22512115
54Decreased electroretinogram (ERG) amplitude (HP:0000654)2.22470166
55Increased serum lactate (HP:0002151)2.22188309
56Reduced antithrombin III activity (HP:0001976)2.15012275
57Exertional dyspnea (HP:0002875)2.14880176
58Abnormality of the renal medulla (HP:0100957)2.14505478
59Severe combined immunodeficiency (HP:0004430)2.13546588
60Abnormality of the phalanges of the 2nd finger (HP:0009541)2.10525794
61Abnormality of B cell number (HP:0010975)2.09639580
62Polydipsia (HP:0001959)2.07486029
63Abnormal drinking behavior (HP:0030082)2.07486029
64Increased intramyocellular lipid droplets (HP:0012240)2.06056867
65Autoimmune thrombocytopenia (HP:0001973)2.05889373
66Thyroiditis (HP:0100646)2.05304255
67Lactic acidosis (HP:0003128)2.01723651
68Constricted visual fields (HP:0001133)2.01041250
69Lethargy (HP:0001254)2.00227635
70Renal Fanconi syndrome (HP:0001994)1.99846798
71Methylmalonic aciduria (HP:0012120)1.97347539
72Congenital primary aphakia (HP:0007707)1.97176692
73Dyschromatopsia (HP:0007641)1.96849231
74Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.95268514
75Hyperglycinuria (HP:0003108)1.94790911
76Muscle fiber atrophy (HP:0100295)1.94012832
77Ketosis (HP:0001946)1.93721755
78Autoimmune hemolytic anemia (HP:0001890)1.93171990
79Gait imbalance (HP:0002141)1.92610019
80Abnormality of glycine metabolism (HP:0010895)1.91986163
81Abnormality of serine family amino acid metabolism (HP:0010894)1.91986163
82Spastic paraparesis (HP:0002313)1.91287815
83Abnormal ciliary motility (HP:0012262)1.91232659
84Abnormality of macular pigmentation (HP:0008002)1.90248399
85Abnormality of the phalanges of the 5th finger (HP:0004213)1.90200576
86Chronic sinusitis (HP:0011109)1.87293292
87Renal cortical cysts (HP:0000803)1.84779080
88Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84348041
89Pancytopenia (HP:0001876)1.83730804
90Sclerocornea (HP:0000647)1.81754860
91Increased corneal curvature (HP:0100692)1.81580232
92Keratoconus (HP:0000563)1.81580232
93Tubular atrophy (HP:0000092)1.79702120
94Central scotoma (HP:0000603)1.79423699
95Supernumerary spleens (HP:0009799)1.78438577
96Absent thumb (HP:0009777)1.78336978
97Nephrogenic diabetes insipidus (HP:0009806)1.77068133
98Prostate neoplasm (HP:0100787)1.75074373
99Polyuria (HP:0000103)1.74983627
100Abnormality of serum amino acid levels (HP:0003112)1.71750029

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK3.31883120
2CDK192.99695266
3GRK12.95487884
4BMPR22.93039633
5FRK2.80229889
6ADRBK22.73510849
7NUAK12.61714835
8TLK12.57807158
9MAP4K22.51340793
10ZAK2.45880716
11TAOK32.37188745
12BCKDK2.08965374
13PINK12.07284029
14STK161.96019120
15WNK41.93226930
16MAP3K121.75896149
17MAP4K11.71337146
18KIT1.60491804
19OXSR11.53349060
20PASK1.48287748
21GRK61.47936453
22TEC1.47153528
23EIF2AK31.40846373
24VRK21.39841028
25CAMKK21.37347827
26ERBB31.37213667
27STK391.31853335
28TIE11.31230631
29ITK1.29759920
30IKBKB1.23020219
31SYK1.22288182
32INSRR1.21711184
33KDR1.19774013
34VRK11.13348807
35CSF1R1.12981964
36DAPK21.09579668
37MKNK11.06982639
38RIPK40.99330829
39WNK30.98496086
40MYLK0.96186698
41BMPR1B0.94813189
42FES0.93450773
43BTK0.93188513
44MAPK130.92881034
45PIK3CA0.91659694
46LYN0.89704661
47TRPM70.89159559
48RPS6KA50.86352995
49MAPKAPK50.84893311
50NEK10.83525328
51PRKCQ0.82644804
52CAMKK10.80024424
53PHKG20.75382394
54PHKG10.75382394
55DAPK30.74626156
56CSNK1G30.74228640
57DAPK10.73726631
58PRKCE0.73102010
59MAP3K40.73032921
60FLT30.72500480
61OBSCN0.72307831
62ADRBK10.71690935
63LCK0.71301907
64DYRK20.70765573
65IKBKE0.65033395
66CSNK1G20.64041489
67MATK0.63144406
68IGF1R0.55769792
69PIK3CG0.55729188
70MKNK20.53970488
71CSNK1G10.52038574
72PLK30.50063639
73MST40.48833827
74CSNK1A1L0.48785402
75PLK20.47568422
76PRKACA0.47284516
77PLK40.46640895
78MAP2K60.46364682
79SCYL20.46182368
80MUSK0.45566280
81TNK20.45553080
82MAP2K70.45432054
83PRKCA0.43758349
84CAMK10.43661900
85PRKCG0.43546054
86JAK30.43340667
87HCK0.41775165
88EIF2AK10.41762478
89GRK70.40364226
90MAPKAPK30.39095849
91RPS6KB20.38492922
92ILK0.38406755
93ABL10.38405146
94CSNK2A10.38309201
95PTK2B0.38220879
96ACVR1B0.37027267
97TNIK0.36960994
98NME10.36525165
99PRKCD0.34805243
100CAMK2A0.34551092

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.35702820
2Ribosome_Homo sapiens_hsa030103.57540110
3Allograft rejection_Homo sapiens_hsa053303.36713784
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.19397082
5Autoimmune thyroid disease_Homo sapiens_hsa053203.16545195
6Oxidative phosphorylation_Homo sapiens_hsa001903.01399527
7Proteasome_Homo sapiens_hsa030502.89485791
8Graft-versus-host disease_Homo sapiens_hsa053322.87541855
9Type I diabetes mellitus_Homo sapiens_hsa049402.59694081
10Parkinsons disease_Homo sapiens_hsa050122.33673817
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.05861155
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.99059095
13Protein export_Homo sapiens_hsa030601.97507640
14Primary immunodeficiency_Homo sapiens_hsa053401.91503440
15Caffeine metabolism_Homo sapiens_hsa002321.89753647
16Phototransduction_Homo sapiens_hsa047441.83423252
17Linoleic acid metabolism_Homo sapiens_hsa005911.77485499
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74557090
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70011354
20RNA polymerase_Homo sapiens_hsa030201.63798798
21Alzheimers disease_Homo sapiens_hsa050101.56893225
22Antigen processing and presentation_Homo sapiens_hsa046121.56679280
23Cardiac muscle contraction_Homo sapiens_hsa042601.51629993
24Huntingtons disease_Homo sapiens_hsa050161.49395892
25RNA degradation_Homo sapiens_hsa030181.48344553
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.44340001
27Rheumatoid arthritis_Homo sapiens_hsa053231.41726708
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.33832700
29One carbon pool by folate_Homo sapiens_hsa006701.25369985
30Propanoate metabolism_Homo sapiens_hsa006401.20998233
31Homologous recombination_Homo sapiens_hsa034401.20671978
32Hematopoietic cell lineage_Homo sapiens_hsa046401.18431956
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.18190048
34Nitrogen metabolism_Homo sapiens_hsa009101.15815836
35Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.11427040
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.10672525
37Basal transcription factors_Homo sapiens_hsa030221.08989368
38Staphylococcus aureus infection_Homo sapiens_hsa051501.06425752
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.05744380
40Fanconi anemia pathway_Homo sapiens_hsa034601.05312565
41Arachidonic acid metabolism_Homo sapiens_hsa005901.01269952
42Butanoate metabolism_Homo sapiens_hsa006500.98927288
43Tryptophan metabolism_Homo sapiens_hsa003800.98641186
44Olfactory transduction_Homo sapiens_hsa047400.97205413
45Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96678624
46Viral myocarditis_Homo sapiens_hsa054160.96618702
47Systemic lupus erythematosus_Homo sapiens_hsa053220.88389189
48Chemical carcinogenesis_Homo sapiens_hsa052040.84216114
49Ether lipid metabolism_Homo sapiens_hsa005650.82407003
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82182959
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82026156
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.79417286
53Pyrimidine metabolism_Homo sapiens_hsa002400.76351592
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75763340
55Purine metabolism_Homo sapiens_hsa002300.73523615
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73108469
57Leishmaniasis_Homo sapiens_hsa051400.71724949
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.70788011
59Retinol metabolism_Homo sapiens_hsa008300.69055987
60Salivary secretion_Homo sapiens_hsa049700.66278982
61Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65747693
62Selenocompound metabolism_Homo sapiens_hsa004500.64387485
63RNA transport_Homo sapiens_hsa030130.64351663
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64176661
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63259854
66Fat digestion and absorption_Homo sapiens_hsa049750.62827457
67Nicotine addiction_Homo sapiens_hsa050330.61913359
68Nucleotide excision repair_Homo sapiens_hsa034200.61782427
69Peroxisome_Homo sapiens_hsa041460.61150791
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60797882
71Spliceosome_Homo sapiens_hsa030400.52084326
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.49932915
73Metabolic pathways_Homo sapiens_hsa011000.49484001
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.46979946
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.46877369
76Taste transduction_Homo sapiens_hsa047420.46175873
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44581235
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44568475
79Ovarian steroidogenesis_Homo sapiens_hsa049130.43911337
80Collecting duct acid secretion_Homo sapiens_hsa049660.40331048
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.39899739
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.39649319
83Regulation of autophagy_Homo sapiens_hsa041400.39301239
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37810756
85Morphine addiction_Homo sapiens_hsa050320.37226361
86Herpes simplex infection_Homo sapiens_hsa051680.33104805
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32629314
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30773595
89Serotonergic synapse_Homo sapiens_hsa047260.30450184
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29596392
91Base excision repair_Homo sapiens_hsa034100.28575905
92Glycerolipid metabolism_Homo sapiens_hsa005610.28102811
93Circadian entrainment_Homo sapiens_hsa047130.26777606
94Starch and sucrose metabolism_Homo sapiens_hsa005000.26699497
95T cell receptor signaling pathway_Homo sapiens_hsa046600.25827025
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24787522
97Fatty acid biosynthesis_Homo sapiens_hsa000610.23918510
98beta-Alanine metabolism_Homo sapiens_hsa004100.20406062
99Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19298487
100ABC transporters_Homo sapiens_hsa020100.16968233

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