RPL7P16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.23357433
2positive regulation of prostaglandin secretion (GO:0032308)4.50894335
3DNA deamination (GO:0045006)4.47665114
4viral transcription (GO:0019083)4.25411657
5translational termination (GO:0006415)4.09880578
6detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.01571412
7energy coupled proton transport, down electrochemical gradient (GO:0015985)3.95996905
8ATP synthesis coupled proton transport (GO:0015986)3.95996905
9behavioral response to nicotine (GO:0035095)3.93650008
10ribosomal large subunit biogenesis (GO:0042273)3.91031337
11positive regulation of fatty acid transport (GO:2000193)3.84421238
12piRNA metabolic process (GO:0034587)3.75926071
13water-soluble vitamin biosynthetic process (GO:0042364)3.75388999
14SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.70471644
15positive regulation of icosanoid secretion (GO:0032305)3.64943530
16cotranslational protein targeting to membrane (GO:0006613)3.64671575
17translational elongation (GO:0006414)3.63146918
18protein targeting to ER (GO:0045047)3.61552253
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.60415522
20RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54559526
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54559526
22kynurenine metabolic process (GO:0070189)3.52394064
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49374897
24protein localization to endoplasmic reticulum (GO:0070972)3.45450096
25establishment of protein localization to endoplasmic reticulum (GO:0072599)3.40242388
26regulation of cilium movement (GO:0003352)3.40229173
27L-fucose metabolic process (GO:0042354)3.37210321
28L-fucose catabolic process (GO:0042355)3.37210321
29fucose catabolic process (GO:0019317)3.37210321
30rRNA modification (GO:0000154)3.36783978
31GPI anchor biosynthetic process (GO:0006506)3.36018324
32regulation of prostaglandin secretion (GO:0032306)3.30714938
33indolalkylamine metabolic process (GO:0006586)3.30710363
34GPI anchor metabolic process (GO:0006505)3.30284798
35tryptophan catabolic process (GO:0006569)3.29046398
36indole-containing compound catabolic process (GO:0042436)3.29046398
37indolalkylamine catabolic process (GO:0046218)3.29046398
38cellular ketone body metabolic process (GO:0046950)3.26091101
39RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17533329
40electron transport chain (GO:0022900)3.15960440
41viral life cycle (GO:0019058)3.14739586
42tryptophan metabolic process (GO:0006568)3.13285726
43maturation of SSU-rRNA (GO:0030490)3.10373741
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.09174180
45DNA methylation involved in gamete generation (GO:0043046)3.08616269
46regulation of microtubule-based movement (GO:0060632)3.06691306
47respiratory electron transport chain (GO:0022904)3.06273283
48respiratory chain complex IV assembly (GO:0008535)3.04974014
49regulation of female receptivity (GO:0045924)3.01376398
50response to pheromone (GO:0019236)3.00630980
51rRNA methylation (GO:0031167)3.00395634
52translational initiation (GO:0006413)2.99179661
53rRNA catabolic process (GO:0016075)2.96685329
54nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.94253337
55ribosomal small subunit biogenesis (GO:0042274)2.93274009
56ketone body metabolic process (GO:1902224)2.91457434
57preassembly of GPI anchor in ER membrane (GO:0016254)2.91432960
58cellular biogenic amine catabolic process (GO:0042402)2.84716792
59amine catabolic process (GO:0009310)2.84716792
60translation (GO:0006412)2.83219742
61epithelial cell maturation (GO:0002070)2.83206034
62cellular protein complex disassembly (GO:0043624)2.81785183
63GTP biosynthetic process (GO:0006183)2.81595754
64hydrogen ion transmembrane transport (GO:1902600)2.81382513
65adaptation of signaling pathway (GO:0023058)2.81041472
66mitochondrial respiratory chain complex I assembly (GO:0032981)2.80805569
67NADH dehydrogenase complex assembly (GO:0010257)2.80805569
68mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.80805569
69S-adenosylmethionine metabolic process (GO:0046500)2.79931211
70protein neddylation (GO:0045116)2.79880807
71proton transport (GO:0015992)2.77952826
72protein complex biogenesis (GO:0070271)2.77790077
73positive regulation of protein homodimerization activity (GO:0090073)2.76755724
74hydrogen transport (GO:0006818)2.76662910
75termination of RNA polymerase III transcription (GO:0006386)2.72153268
76transcription elongation from RNA polymerase III promoter (GO:0006385)2.72153268
77exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.71911583
78phosphatidylinositol acyl-chain remodeling (GO:0036149)2.71553053
79female mating behavior (GO:0060180)2.68877308
80nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68529353
81auditory receptor cell stereocilium organization (GO:0060088)2.60562915
82mitochondrial respiratory chain complex assembly (GO:0033108)2.58408023
83L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.55484954
84positive regulation of T cell cytokine production (GO:0002726)2.53276336
85mannosylation (GO:0097502)2.52287039
86RNA phosphodiester bond hydrolysis (GO:0090501)2.51550025
87viral protein processing (GO:0019082)2.50651417
88cytochrome complex assembly (GO:0017004)2.50069660
89detection of light stimulus involved in sensory perception (GO:0050962)2.49111134
90detection of light stimulus involved in visual perception (GO:0050908)2.49111134
91positive regulation of defense response to virus by host (GO:0002230)2.47687499
92positive regulation of steroid hormone secretion (GO:2000833)2.47560751
93pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.46780478
94ovulation cycle (GO:0042698)2.45684225
95positive regulation of organic acid transport (GO:0032892)2.44608198
96phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.42295543
97regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42219115
98tRNA processing (GO:0008033)2.42057012
99regulation of icosanoid secretion (GO:0032303)2.41614867
100proteasome assembly (GO:0043248)2.41286197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.59772582
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.58014066
3EZH2_22144423_ChIP-Seq_EOC_Human3.42163432
4VDR_22108803_ChIP-Seq_LS180_Human3.14439505
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.93193786
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.92480983
7IGF1R_20145208_ChIP-Seq_DFB_Human2.52717316
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52433408
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.52422288
10IRF1_19129219_ChIP-ChIP_H3396_Human2.51074154
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.50071554
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.41851628
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.13187612
14VDR_23849224_ChIP-Seq_CD4+_Human2.08046401
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00970096
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.00556097
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.99345219
18TP53_22573176_ChIP-Seq_HFKS_Human1.93746359
19FLI1_27457419_Chip-Seq_LIVER_Mouse1.85382846
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.85264893
21ETS1_20019798_ChIP-Seq_JURKAT_Human1.84171216
22EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.76299231
23FOXA1_27270436_Chip-Seq_PROSTATE_Human1.72498174
24FOXA1_25329375_ChIP-Seq_VCAP_Human1.72498174
25EWS_26573619_Chip-Seq_HEK293_Human1.71011882
26PCGF2_27294783_Chip-Seq_ESCs_Mouse1.65668960
27AR_20517297_ChIP-Seq_VCAP_Human1.65607582
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63626176
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63182216
30PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61730249
31GATA3_26560356_Chip-Seq_TH2_Human1.56075198
32FUS_26573619_Chip-Seq_HEK293_Human1.52449959
33ELK1_19687146_ChIP-ChIP_HELA_Human1.50743653
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50232300
35AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.48813035
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48401058
37ER_23166858_ChIP-Seq_MCF-7_Human1.47739584
38GATA3_21878914_ChIP-Seq_MCF-7_Human1.45505290
39FOXP3_21729870_ChIP-Seq_TREG_Human1.42431586
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39438455
41MYC_18940864_ChIP-ChIP_HL60_Human1.38758617
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37121814
43NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36963614
44AR_21572438_ChIP-Seq_LNCaP_Human1.35822029
45MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.35302907
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.33823091
47CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33706615
48HOXB7_26014856_ChIP-Seq_BT474_Human1.32500970
49SOX2_19829295_ChIP-Seq_ESCs_Human1.31219247
50NANOG_19829295_ChIP-Seq_ESCs_Human1.31219247
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29636203
52CBP_20019798_ChIP-Seq_JUKART_Human1.29636203
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.25063101
54PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22242921
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22054702
56TAF2_19829295_ChIP-Seq_ESCs_Human1.21882609
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.21139794
58P53_21459846_ChIP-Seq_SAOS-2_Human1.19038981
59NCOR_22424771_ChIP-Seq_293T_Human1.17683775
60STAT1_20625510_ChIP-Seq_HELA_Human1.17135298
61TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15435062
62FOXA1_25552417_ChIP-Seq_VCAP_Human1.15050428
63P300_19829295_ChIP-Seq_ESCs_Human1.12659641
64CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.11628771
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.10218102
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09237248
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09085358
68NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08103470
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.06858231
70ERA_21632823_ChIP-Seq_H3396_Human1.06598875
71MYC_19829295_ChIP-Seq_ESCs_Human1.06227949
72EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04258573
73AR_25329375_ChIP-Seq_VCAP_Human1.04194709
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.03947111
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.03929011
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03252833
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01322020
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.01150216
79NANOG_20526341_ChIP-Seq_ESCs_Human1.00955075
80YY1_21170310_ChIP-Seq_MESCs_Mouse1.00744144
81FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.00003587
82FOXH1_21741376_ChIP-Seq_EPCs_Human0.99580275
83GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99179835
84TCF4_22108803_ChIP-Seq_LS180_Human0.98829872
85TAF15_26573619_Chip-Seq_HEK293_Human0.96993105
86SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96311826
87RAC3_21632823_ChIP-Seq_H3396_Human0.96282597
88EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.96143973
89STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95668399
90PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94271298
91FOXH1_21741376_ChIP-Seq_ESCs_Human0.93999989
92KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93398310
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.93071601
94PADI4_21655091_ChIP-ChIP_MCF-7_Human0.92765735
95SMRT_27268052_Chip-Seq_Bcells_Human0.92505754
96P300_27268052_Chip-Seq_Bcells_Human0.92360154
97TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91762866
98TTF2_22483619_ChIP-Seq_HELA_Human0.91732673
99NFE2_27457419_Chip-Seq_LIVER_Mouse0.91395098
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89739390

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002876_abnormal_thyroid_physiology3.26533398
2MP0005646_abnormal_pituitary_gland3.19661787
3MP0004043_abnormal_pH_regulation2.89171409
4MP0001968_abnormal_touch/_nociception2.67500294
5MP0009379_abnormal_foot_pigmentation2.65153370
6MP0004145_abnormal_muscle_electrophysio2.47977909
7MP0002138_abnormal_hepatobiliary_system2.47977788
8MP0002234_abnormal_pharynx_morphology2.45741935
9MP0006072_abnormal_retinal_apoptosis2.32933787
10MP0008872_abnormal_physiological_respon2.32026711
11MP0003646_muscle_fatigue2.20640562
12MP0006292_abnormal_olfactory_placode2.05783035
13MP0002736_abnormal_nociception_after1.99683088
14MP0001919_abnormal_reproductive_system1.98747576
15MP0005085_abnormal_gallbladder_physiolo1.94675511
16MP0001835_abnormal_antigen_presentation1.89444154
17MP0005551_abnormal_eye_electrophysiolog1.84958724
18MP0005084_abnormal_gallbladder_morpholo1.79938137
19MP0000685_abnormal_immune_system1.79651397
20MP0008775_abnormal_heart_ventricle1.74717337
21MP0005645_abnormal_hypothalamus_physiol1.71789526
22MP0004885_abnormal_endolymph1.66477735
23MP0003011_delayed_dark_adaptation1.66294614
24MP0008877_abnormal_DNA_methylation1.63284421
25MP0001501_abnormal_sleep_pattern1.61737632
26MP0008875_abnormal_xenobiotic_pharmacok1.61316135
27MP0003195_calcinosis1.61122985
28MP0001986_abnormal_taste_sensitivity1.60367195
29MP0003724_increased_susceptibility_to1.59615120
30MP0000230_abnormal_systemic_arterial1.55066556
31MP0002102_abnormal_ear_morphology1.54751503
32MP0005167_abnormal_blood-brain_barrier1.48567722
33MP0002166_altered_tumor_susceptibility1.44158391
34MP0002735_abnormal_chemical_nociception1.42882458
35MP0003866_abnormal_defecation1.42803957
36MP0005389_reproductive_system_phenotype1.40455793
37MP0002837_dystrophic_cardiac_calcinosis1.39135956
38MP0001765_abnormal_ion_homeostasis1.36005442
39MP0002006_tumorigenesis1.33089387
40MP0005253_abnormal_eye_physiology1.30107495
41MP0006276_abnormal_autonomic_nervous1.27742694
42MP0001502_abnormal_circadian_rhythm1.27053594
43MP0001984_abnormal_olfaction1.26011751
44MP0005220_abnormal_exocrine_pancreas1.25728816
45MP0002148_abnormal_hypersensitivity_rea1.25545190
46MP0002733_abnormal_thermal_nociception1.25044172
47MP0005636_abnormal_mineral_homeostasis1.23052443
48MP0004142_abnormal_muscle_tone1.22879510
49MP0005671_abnormal_response_to1.21671982
50MP0001440_abnormal_grooming_behavior1.21661070
51MP0001970_abnormal_pain_threshold1.21570258
52MP0009764_decreased_sensitivity_to1.20352648
53MP0001485_abnormal_pinna_reflex1.16834139
54MP0003315_abnormal_perineum_morphology1.16699972
55MP0002272_abnormal_nervous_system1.14564806
56MP0008789_abnormal_olfactory_epithelium1.14487844
57MP0000613_abnormal_salivary_gland1.12545134
58MP0000427_abnormal_hair_cycle1.09793840
59MP0001756_abnormal_urination1.09389717
60MP0000538_abnormal_urinary_bladder1.05402335
61MP0002557_abnormal_social/conspecific_i1.03436989
62MP0002160_abnormal_reproductive_system1.03260746
63MP0000372_irregular_coat_pigmentation1.01614146
64MP0000631_abnormal_neuroendocrine_gland0.94121320
65MP0002822_catalepsy0.94055211
66MP0009745_abnormal_behavioral_response0.94025922
67MP0000537_abnormal_urethra_morphology0.93761602
68MP0001873_stomach_inflammation0.92774795
69MP0005647_abnormal_sex_gland0.91255908
70MP0006036_abnormal_mitochondrial_physio0.91194499
71MP0005377_hearing/vestibular/ear_phenot0.90406342
72MP0003878_abnormal_ear_physiology0.90406342
73MP0001486_abnormal_startle_reflex0.89763868
74MP0004782_abnormal_surfactant_physiolog0.89275202
75MP0004019_abnormal_vitamin_homeostasis0.89260371
76MP0001800_abnormal_humoral_immune0.89118762
77MP0002638_abnormal_pupillary_reflex0.86520103
78MP0004742_abnormal_vestibular_system0.86129711
79MP0003786_premature_aging0.86113564
80MP0002163_abnormal_gland_morphology0.86112275
81MP0010155_abnormal_intestine_physiology0.85135312
82MP0005367_renal/urinary_system_phenotyp0.84920021
83MP0000516_abnormal_urinary_system0.84920021
84MP0003879_abnormal_hair_cell0.84493132
85MP0008007_abnormal_cellular_replicative0.83390122
86MP0001905_abnormal_dopamine_level0.83109027
87MP0010386_abnormal_urinary_bladder0.82976327
88MP0005310_abnormal_salivary_gland0.80482268
89MP0001663_abnormal_digestive_system0.78994975
90MP0005365_abnormal_bile_salt0.78460128
91MP0009785_altered_susceptibility_to0.74711752
92MP0002572_abnormal_emotion/affect_behav0.73358508
93MP0003638_abnormal_response/metabolism_0.73189094
94MP0005394_taste/olfaction_phenotype0.71098505
95MP0005499_abnormal_olfactory_system0.71098505
96MP0002723_abnormal_immune_serum0.70697241
97MP0008995_early_reproductive_senescence0.70691635
98MP0001293_anophthalmia0.70483858
99MP0005332_abnormal_amino_acid0.69632202
100MP0003936_abnormal_reproductive_system0.69156101

Predicted human phenotypes

RankGene SetZ-score
1Type II lissencephaly (HP:0007260)4.05853158
2Congenital, generalized hypertrichosis (HP:0004540)3.76110165
3Acute necrotizing encephalopathy (HP:0006965)3.60534328
4Pancreatic cysts (HP:0001737)3.57553157
5Decreased circulating renin level (HP:0003351)3.56452797
6Abnormality of midbrain morphology (HP:0002418)3.36703354
7Molar tooth sign on MRI (HP:0002419)3.36703354
8Acute encephalopathy (HP:0006846)3.31545918
93-Methylglutaconic aciduria (HP:0003535)3.23783774
10Mitochondrial inheritance (HP:0001427)3.17318461
11Pancreatic fibrosis (HP:0100732)3.11338350
12Nephronophthisis (HP:0000090)3.09020654
13Cerebellar dysplasia (HP:0007033)3.05335210
14Abnormal mitochondria in muscle tissue (HP:0008316)3.04705576
15Congenital stationary night blindness (HP:0007642)3.04414756
16Progressive macrocephaly (HP:0004481)3.04084582
17Increased CSF lactate (HP:0002490)2.98443736
18Abolished electroretinogram (ERG) (HP:0000550)2.84625043
19True hermaphroditism (HP:0010459)2.84530188
20Hypoplasia of the uterus (HP:0000013)2.74704742
21Abnormality of the renal cortex (HP:0011035)2.72807948
22Abnormality of the renal medulla (HP:0100957)2.71000700
23Methylmalonic acidemia (HP:0002912)2.70695123
24Hepatocellular necrosis (HP:0001404)2.70086855
25Abnormality of cells of the erythroid lineage (HP:0012130)2.69385914
26Keratoconus (HP:0000563)2.63020420
27Increased corneal curvature (HP:0100692)2.63020420
28Aplasia/hypoplasia of the uterus (HP:0008684)2.62897318
29IgG deficiency (HP:0004315)2.58132985
30Renal cortical cysts (HP:0000803)2.49659684
31Prostate neoplasm (HP:0100787)2.48773405
32Abnormality of the prostate (HP:0008775)2.47300913
33Stomatitis (HP:0010280)2.45920289
34Sensorimotor neuropathy (HP:0007141)2.42932831
35Hepatic necrosis (HP:0002605)2.40071945
36Decreased electroretinogram (ERG) amplitude (HP:0000654)2.39007338
37Lipid accumulation in hepatocytes (HP:0006561)2.36816417
38Methylmalonic aciduria (HP:0012120)2.36570119
39Optic disc pallor (HP:0000543)2.35706885
40Absent rod-and cone-mediated responses on ERG (HP:0007688)2.34943495
41Abnormality of the proximal phalanges of the hand (HP:0009834)2.34476628
42Abnormal rod and cone electroretinograms (HP:0008323)2.33615629
43Attenuation of retinal blood vessels (HP:0007843)2.32956902
44Delayed CNS myelination (HP:0002188)2.32434070
45Medial flaring of the eyebrow (HP:0010747)2.31861599
46Reticulocytopenia (HP:0001896)2.31608447
47Bile duct proliferation (HP:0001408)2.30429043
48Abnormal biliary tract physiology (HP:0012439)2.30429043
49Aplasia/Hypoplasia of the spleen (HP:0010451)2.28079258
50Chronic bronchitis (HP:0004469)2.25299196
51Fibular aplasia (HP:0002990)2.24721305
52Increased hepatocellular lipid droplets (HP:0006565)2.23845796
53Abnormality of the axillary hair (HP:0100134)2.22312574
54Abnormality of secondary sexual hair (HP:0009888)2.22312574
55Cerebral edema (HP:0002181)2.21256079
56Elevated erythrocyte sedimentation rate (HP:0003565)2.20413021
57Decreased central vision (HP:0007663)2.19213076
58Cystic liver disease (HP:0006706)2.19089014
59Hypokalemic alkalosis (HP:0001949)2.18361884
60Asplenia (HP:0001746)2.17452574
61Abnormal number of erythroid precursors (HP:0012131)2.16526128
62Testicular atrophy (HP:0000029)2.15408443
63Abnormal ciliary motility (HP:0012262)2.14340634
64Absent/shortened dynein arms (HP:0200106)2.13375851
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.13375851
66Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11594932
67Abnormality of alanine metabolism (HP:0010916)2.11594932
68Hyperalaninemia (HP:0003348)2.11594932
69Ketosis (HP:0001946)2.11222989
70Increased serum lactate (HP:0002151)2.08834444
71Pendular nystagmus (HP:0012043)2.08257191
72Clumsiness (HP:0002312)2.05622607
73Polydipsia (HP:0001959)2.04761808
74Abnormal drinking behavior (HP:0030082)2.04761808
75Retinal dysplasia (HP:0007973)2.01549171
76Abnormality of the pons (HP:0007361)2.00336295
77Sclerocornea (HP:0000647)1.93388332
78Macrocytic anemia (HP:0001972)1.92856528
79Abnormality of renin-angiotensin system (HP:0000847)1.92754217
80Hypoplasia of the pons (HP:0012110)1.91875010
81Postaxial foot polydactyly (HP:0001830)1.89047566
82Male pseudohermaphroditism (HP:0000037)1.87725476
83Tubular atrophy (HP:0000092)1.87402539
84Hypoplasia of the ulna (HP:0003022)1.86110081
85Chronic hepatic failure (HP:0100626)1.84475324
86Intrahepatic cholestasis (HP:0001406)1.83659771
87Abnormal respiratory epithelium morphology (HP:0012253)1.83430906
88Abnormal respiratory motile cilium morphology (HP:0005938)1.83430906
89Hypoproteinemia (HP:0003075)1.81838779
90Short 1st metacarpal (HP:0010034)1.81369410
91Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.81369410
92Amelogenesis imperfecta (HP:0000705)1.77274225
93Aplasia/Hypoplasia of the ulna (HP:0006495)1.75542865
94Ketoacidosis (HP:0001993)1.75455715
95Microretrognathia (HP:0000308)1.74000958
96Increased intramyocellular lipid droplets (HP:0012240)1.73326208
97Abnormality of B cell number (HP:0010975)1.73319230
98Alkalosis (HP:0001948)1.71755452
99Thyroiditis (HP:0100646)1.71746924
100Lactic acidosis (HP:0003128)1.71718494

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.64556113
2MAP4K23.53041558
3WNK43.21047394
4TAOK33.18829393
5NUAK12.83348839
6FRK2.79754927
7BMPR1B2.79232621
8STK162.77281831
9TLK12.73538630
10STK392.43947493
11ADRBK22.32461933
12TXK2.29051990
13TNK22.17793679
14GRK12.14091432
15ZAK2.13953095
16OXSR11.88100382
17EIF2AK31.77791639
18PINK11.70686976
19CDK191.57987591
20TIE11.56542107
21AKT31.51231023
22BCKDK1.50455569
23SCYL21.50092117
24CAMKK21.34434952
25PHKG21.33733402
26PHKG11.33733402
27PIK3CA1.31512195
28MYLK1.30086983
29TEC1.23051072
30MAPKAPK31.22623313
31VRK21.17983389
32DAPK21.11152949
33CDK81.09234414
34MAP2K21.09030906
35FLT31.07277905
36RPS6KA51.03240492
37IKBKB1.02341351
38DYRK20.95243056
39ACVR1B0.95059446
40KIT0.94760754
41NME20.93551925
42GRK60.88967109
43DAPK30.87801567
44RIPK40.86546301
45ERBB30.83685304
46MAPK130.82554108
47MAP3K120.81426967
48VRK10.78238980
49BMPR20.76200662
50ITK0.76186958
51TGFBR10.75344308
52CSF1R0.74039674
53PLK20.73685343
54FER0.71379885
55FES0.71087452
56MAPKAPK50.69862624
57ADRBK10.69320523
58PAK30.69178267
59WNK30.69069925
60CHUK0.68791210
61PRKCE0.68773357
62EPHA30.68332690
63DAPK10.67594293
64WNK10.66435268
65PIK3CG0.65121929
66MAP4K10.60121860
67ILK0.59052729
68MAP2K60.58513109
69IRAK10.57188039
70CSNK1G20.56698654
71CAMKK10.56269429
72EIF2AK20.55580786
73CAMK10.55251674
74TRIM280.53800635
75RPS6KB20.52754763
76CSNK1G30.52648979
77CSNK1A1L0.52002961
78TRPM70.51387602
79NEK10.50537456
80MAP3K130.49519523
81SYK0.48873645
82PLK30.48730366
83CAMK1D0.48677350
84PRKCQ0.48226268
85PRKCI0.46615469
86LYN0.42892578
87RPS6KA60.42535242
88MKNK20.42503800
89CSNK1G10.41973870
90CSNK1A10.41675197
91PRKAA20.41384249
92PRKCG0.41228723
93IGF1R0.39904646
94PRKACA0.39191314
95EIF2AK10.37221593
96LRRK20.36476522
97CSNK2A20.34385298
98EEF2K0.33416063
99IKBKE0.32854558
100PKN10.32377797

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.74335001
2Asthma_Homo sapiens_hsa053103.73628414
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.06163387
4Oxidative phosphorylation_Homo sapiens_hsa001902.91642051
5Allograft rejection_Homo sapiens_hsa053302.58751566
6Autoimmune thyroid disease_Homo sapiens_hsa053202.43454144
7Protein export_Homo sapiens_hsa030602.33048980
8Parkinsons disease_Homo sapiens_hsa050122.18725202
9Linoleic acid metabolism_Homo sapiens_hsa005912.16922121
10Graft-versus-host disease_Homo sapiens_hsa053322.14451185
11Type I diabetes mellitus_Homo sapiens_hsa049402.08431227
12Proteasome_Homo sapiens_hsa030502.07815088
13Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.04545498
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.97806993
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.93551857
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87081784
17RNA polymerase_Homo sapiens_hsa030201.84116205
18Arachidonic acid metabolism_Homo sapiens_hsa005901.57351522
19Phototransduction_Homo sapiens_hsa047441.56011734
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54762248
21Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53300510
22Butanoate metabolism_Homo sapiens_hsa006501.50437071
23RNA degradation_Homo sapiens_hsa030181.50427464
24Peroxisome_Homo sapiens_hsa041461.50402570
25Huntingtons disease_Homo sapiens_hsa050161.50094916
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.48195532
27Alzheimers disease_Homo sapiens_hsa050101.44209166
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42359639
29Cardiac muscle contraction_Homo sapiens_hsa042601.41811649
30Tryptophan metabolism_Homo sapiens_hsa003801.39288989
31Nitrogen metabolism_Homo sapiens_hsa009101.38398454
32Ether lipid metabolism_Homo sapiens_hsa005651.36684309
33One carbon pool by folate_Homo sapiens_hsa006701.34657767
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.31338234
35Propanoate metabolism_Homo sapiens_hsa006401.29488002
36Rheumatoid arthritis_Homo sapiens_hsa053231.26981812
37Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.26050389
38Caffeine metabolism_Homo sapiens_hsa002321.20157843
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16641941
40Primary immunodeficiency_Homo sapiens_hsa053401.13942926
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13074650
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13020424
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12140340
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10571129
45Chemical carcinogenesis_Homo sapiens_hsa052041.09856280
46Basal transcription factors_Homo sapiens_hsa030221.09461853
47Homologous recombination_Homo sapiens_hsa034401.07167064
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.04210521
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03255218
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.01550905
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.98107326
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97583463
53Olfactory transduction_Homo sapiens_hsa047400.96609882
54Pyrimidine metabolism_Homo sapiens_hsa002400.86863360
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.85453998
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84956928
57Purine metabolism_Homo sapiens_hsa002300.84826327
58Antigen processing and presentation_Homo sapiens_hsa046120.84527521
59Retinol metabolism_Homo sapiens_hsa008300.83920816
60Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82166057
61Fanconi anemia pathway_Homo sapiens_hsa034600.81550112
62Selenocompound metabolism_Homo sapiens_hsa004500.74873605
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71262894
64Systemic lupus erythematosus_Homo sapiens_hsa053220.71245820
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70627115
66Salivary secretion_Homo sapiens_hsa049700.69332205
67Fat digestion and absorption_Homo sapiens_hsa049750.68448311
68RNA transport_Homo sapiens_hsa030130.65693665
69Taste transduction_Homo sapiens_hsa047420.65393772
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.62851457
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.61742922
72Mineral absorption_Homo sapiens_hsa049780.57271942
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56785338
74Metabolic pathways_Homo sapiens_hsa011000.56418565
75Arginine and proline metabolism_Homo sapiens_hsa003300.56173015
76Sulfur metabolism_Homo sapiens_hsa009200.54208917
77Staphylococcus aureus infection_Homo sapiens_hsa051500.50172722
78Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.49779353
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49244166
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47548390
81Nicotine addiction_Homo sapiens_hsa050330.46680125
82Serotonergic synapse_Homo sapiens_hsa047260.45098798
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.44395373
84Glutathione metabolism_Homo sapiens_hsa004800.42053909
85Collecting duct acid secretion_Homo sapiens_hsa049660.41409078
86Vitamin digestion and absorption_Homo sapiens_hsa049770.39693770
87Viral myocarditis_Homo sapiens_hsa054160.38586226
88Drug metabolism - other enzymes_Homo sapiens_hsa009830.38359919
89Base excision repair_Homo sapiens_hsa034100.36619152
90Steroid biosynthesis_Homo sapiens_hsa001000.36128687
91Circadian rhythm_Homo sapiens_hsa047100.35887763
92Hematopoietic cell lineage_Homo sapiens_hsa046400.35609549
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.32725027
94Non-homologous end-joining_Homo sapiens_hsa034500.32640839
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32468393
96Ovarian steroidogenesis_Homo sapiens_hsa049130.31310935
97Morphine addiction_Homo sapiens_hsa050320.30665234
98beta-Alanine metabolism_Homo sapiens_hsa004100.29375050
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29118998
100Phenylalanine metabolism_Homo sapiens_hsa003600.26905540

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