ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	piRNA metabolic process (GO:0034587)	6.13025731
2	DNA methylation involved in gamete generation (GO:0043046)	4.51168856
3	DNA deamination (GO:0045006)	4.41437446
4	tryptophan catabolic process (GO:0006569)	4.28043843
5	indole-containing compound catabolic process (GO:0042436)	4.28043843
6	indolalkylamine catabolic process (GO:0046218)	4.28043843
7	kynurenine metabolic process (GO:0070189)	3.99940949
8	immunoglobulin mediated immune response (GO:0016064)	3.80574001
9	proteasome assembly (GO:0043248)	3.43406319
10	water-soluble vitamin biosynthetic process (GO:0042364)	3.34393090
11	regulation of interleukin-6 biosynthetic process (GO:0045408)	3.33868128
12	tryptophan metabolic process (GO:0006568)	3.33818193
13	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.32670766
14	ATP synthesis coupled proton transport (GO:0015986)	3.32670766
15	negative regulation of mast cell activation (GO:0033004)	3.27990644
16	regulation of isotype switching to IgG isotypes (GO:0048302)	3.24849088
17	regulation of immunoglobulin secretion (GO:0051023)	3.19268905
18	B cell mediated immunity (GO:0019724)	3.18085895
19	microglial cell activation (GO:0001774)	3.17103888
20	interferon-gamma-mediated signaling pathway (GO:0060333)	3.08352351
21	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	3.05587640
22	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	3.03058254
23	protein neddylation (GO:0045116)	3.02287879
24	activated T cell proliferation (GO:0050798)	2.96043077
25	respiratory chain complex IV assembly (GO:0008535)	2.94956873
26	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.92944265
27	NAD biosynthetic process (GO:0009435)	2.92305959
28	amine catabolic process (GO:0009310)	2.91145304
29	cellular biogenic amine catabolic process (GO:0042402)	2.91145304
30	indolalkylamine metabolic process (GO:0006586)	2.90453691
31	regulation of B cell apoptotic process (GO:0002902)	2.87120191
32	cytochrome complex assembly (GO:0017004)	2.86066175
33	defense response to protozoan (GO:0042832)	2.85868310
34	ribosomal large subunit biogenesis (GO:0042273)	2.85244101
35	positive regulation by symbiont of host defense response (GO:0052509)	2.84745863
36	modulation by symbiont of host defense response (GO:0052031)	2.84745863
37	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	2.84745863
38	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	2.84745863
39	positive regulation by organism of defense response of other organism involved in symbiotic interact	2.84745863
40	modulation by symbiont of host immune response (GO:0052553)	2.84745863
41	protein complex biogenesis (GO:0070271)	2.83292052
42	positive regulation of DNA recombination (GO:0045911)	2.83288855
43	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.79808481
44	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.78048595
45	mast cell activation (GO:0045576)	2.76813185
46	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.76710400
47	tyrosine phosphorylation of STAT protein (GO:0007260)	2.76472426
48	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.71401784
49	positive regulation of interleukin-17 production (GO:0032740)	2.69887374
50	cellular response to ATP (GO:0071318)	2.68944623
51	positive regulation of prostaglandin secretion (GO:0032308)	2.67088290
52	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.65538032
53	NADH dehydrogenase complex assembly (GO:0010257)	2.65538032
54	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.65538032
55	T-helper 1 type immune response (GO:0042088)	2.65173819
56	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.63856401
57	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.63399907
58	cell wall macromolecule metabolic process (GO:0044036)	2.63201597
59	regulation of B cell receptor signaling pathway (GO:0050855)	2.62751706
60	positive regulation of defense response to virus by host (GO:0002230)	2.58323342
61	negative regulation of T cell differentiation in thymus (GO:0033085)	2.57575154
62	rRNA modification (GO:0000154)	2.57231998
63	negative regulation of interleukin-12 production (GO:0032695)	2.56734627
64	cellular response to interferon-gamma (GO:0071346)	2.54816641
65	positive regulation of interleukin-12 production (GO:0032735)	2.53131803
66	positive regulation of isotype switching (GO:0045830)	2.52901262
67	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.51656196
68	mast cell degranulation (GO:0043303)	2.51571436
69	mast cell activation involved in immune response (GO:0002279)	2.51571436
70	maturation of SSU-rRNA (GO:0030490)	2.50657391
71	cell wall macromolecule catabolic process (GO:0016998)	2.49537414
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.47745537
73	regulation of inflammatory response to antigenic stimulus (GO:0002861)	2.45906005
74	male meiosis I (GO:0007141)	2.45872183
75	response to protozoan (GO:0001562)	2.45545647
76	positive regulation of interleukin-8 biosynthetic process (GO:0045416)	2.44517214
77	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.43698022
78	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.43298769
79	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.41876895
80	response to host immune response (GO:0052572)	2.41876895
81	DNA double-strand break processing (GO:0000729)	2.40750648
82	regulation of thymocyte apoptotic process (GO:0070243)	2.40425074
83	positive regulation of T cell migration (GO:2000406)	2.39331910
84	alpha-beta T cell differentiation involved in immune response (GO:0002293)	2.38923651
85	alpha-beta T cell activation involved in immune response (GO:0002287)	2.38923651
86	T cell differentiation involved in immune response (GO:0002292)	2.38923651
87	detection of molecule of bacterial origin (GO:0032490)	2.38729015
88	regulation of interleukin-1 beta secretion (GO:0050706)	2.38152219
89	cellular response to exogenous dsRNA (GO:0071360)	2.37996307
90	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.37525732
91	positive regulation of immunoglobulin mediated immune response (GO:0002891)	2.36921279
92	positive regulation of B cell mediated immunity (GO:0002714)	2.36921279
93	cytidine metabolic process (GO:0046087)	2.36744623
94	cytidine catabolic process (GO:0006216)	2.36744623
95	cytidine deamination (GO:0009972)	2.36744623
96	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.36393154
97	maturation of 5.8S rRNA (GO:0000460)	2.36075788
98	positive regulation of interleukin-1 secretion (GO:0050716)	2.35949216
99	positive regulation of fatty acid transport (GO:2000193)	2.35828140
100	behavioral response to nicotine (GO:0035095)	2.35365699

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.92410323
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.83504897
3	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.70460764
4	IRF8_21731497_ChIP-ChIP_J774_Mouse	3.25527312
5	VDR_22108803_ChIP-Seq_LS180_Human	3.01375713
6	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.89384841
7	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.83377723
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.79166940
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.58032994
10	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.54232330
11	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.33563915
12	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.27711375
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.13720944
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.02700196
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.94483340
16	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.94067853
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.85757945
18	EZH2_22144423_ChIP-Seq_EOC_Human	1.78108577
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.75449859
20	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74969752
21	GATA3_26560356_Chip-Seq_TH2_Human	1.74130434
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.70457283
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.66496224
24	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.63833105
25	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.54976909
26	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52560274
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.52289326
28	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.51585803
29	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.51363038
30	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.51363038
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.50245074
32	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.48771315
33	EWS_26573619_Chip-Seq_HEK293_Human	1.46584068
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.46162979
35	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.42638177
36	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.38736455
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38378136
38	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37828549
39	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.37688428
40	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.37337513
41	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.32570284
42	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.29752653
43	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.27721454
44	SPI1_23547873_ChIP-Seq_NB4_Human	1.27157449
45	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23140984
46	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.21795943
47	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21739036
48	AR_20517297_ChIP-Seq_VCAP_Human	1.21702117
49	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.21416624
50	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20779200
51	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20020275
52	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20020275
53	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.18864569
54	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.18298627
55	FUS_26573619_Chip-Seq_HEK293_Human	1.15598001
56	MYB_26560356_Chip-Seq_TH2_Human	1.14379512
57	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.14068984
58	TAF2_19829295_ChIP-Seq_ESCs_Human	1.13711322
59	TAF15_26573619_Chip-Seq_HEK293_Human	1.12655130
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.12455276
61	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.12455276
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.12440342
63	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.10798877
64	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.10243601
65	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.09890968
66	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.09592883
67	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08890801
68	P300_19829295_ChIP-Seq_ESCs_Human	1.08609763
69	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07760227
70	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07359494
71	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.06965727
72	GATA3_27048872_Chip-Seq_THYMUS_Human	1.06002171
73	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04693301
74	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.02375950
75	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.01738401
76	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01588304
77	STAT1_20625510_ChIP-Seq_HELA_Human	1.00889064
78	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.00236101
79	SCL_19346495_ChIP-Seq_HPC-7_Human	0.99514013
80	NCOR_22424771_ChIP-Seq_293T_Human	0.99314107
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.97871222
82	SMRT_27268052_Chip-Seq_Bcells_Human	0.97740400
83	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.96714109
84	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.96577850
85	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.96163399
86	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	0.95582455
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.94984000
88	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.91418442
89	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.91118568
90	GATA3_26560356_Chip-Seq_TH1_Human	0.91053954
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.90082332
92	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.88378305
93	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.88378305
94	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.86866498
95	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.85869073
96	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.85701050
97	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.84693206
98	TCF4_22108803_ChIP-Seq_LS180_Human	0.84375733
99	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.83507893
100	TCF4_23295773_ChIP-Seq_U87_Human	0.83212068

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.45097623
2	MP0005671_abnormal_response_to	3.46751902
3	MP0003724_increased_susceptibility_to	3.39303607
4	MP0002138_abnormal_hepatobiliary_system	3.17070893
5	MP0008875_abnormal_xenobiotic_pharmacok	2.84355735
6	MP0002148_abnormal_hypersensitivity_rea	2.72628251
7	MP0003806_abnormal_nucleotide_metabolis	2.67786494
8	MP0000685_abnormal_immune_system	2.51222359
9	MP0009785_altered_susceptibility_to	2.36145244
10	MP0009379_abnormal_foot_pigmentation	2.33101648
11	MP0000569_abnormal_digit_pigmentation	2.30762817
12	MP0001790_abnormal_immune_system	2.28845943
13	MP0005387_immune_system_phenotype	2.28845943
14	MP0003195_calcinosis	2.27224608
15	MP0006082_CNS_inflammation	2.23259371
16	MP0001800_abnormal_humoral_immune	2.15794015
17	MP0008877_abnormal_DNA_methylation	2.07580896
18	MP0005000_abnormal_immune_tolerance	1.99453879
19	MP0003646_muscle_fatigue	1.96241498
20	MP0002876_abnormal_thyroid_physiology	1.95851468
21	MP0005084_abnormal_gallbladder_morpholo	1.93656311
22	MP0002723_abnormal_immune_serum	1.85809935
23	MP0005174_abnormal_tail_pigmentation	1.84510040
24	MP0002139_abnormal_hepatobiliary_system	1.80614174
25	MP0002452_abnormal_antigen_presenting	1.79326601
26	MP0005167_abnormal_blood-brain_barrier	1.77398448
27	MP0002102_abnormal_ear_morphology	1.71913447
28	MP0002166_altered_tumor_susceptibility	1.69262317
29	MP0004145_abnormal_muscle_electrophysio	1.67775401
30	MP0002419_abnormal_innate_immunity	1.66429182
31	MP0003436_decreased_susceptibility_to	1.66121410
32	MP0001968_abnormal_touch/_nociception	1.64197495
33	MP0003303_peritoneal_inflammation	1.58888948
34	MP0001819_abnormal_immune_cell	1.58677083
35	MP0005646_abnormal_pituitary_gland	1.57359057
36	MP0002420_abnormal_adaptive_immunity	1.57215237
37	MP0001873_stomach_inflammation	1.52150480
38	MP0009764_decreased_sensitivity_to	1.46078478
39	MP0005025_abnormal_response_to	1.45708276
40	MP0000015_abnormal_ear_pigmentation	1.44915640
41	MP0002277_abnormal_respiratory_mucosa	1.41247845
42	MP0010155_abnormal_intestine_physiology	1.36618702
43	MP0001845_abnormal_inflammatory_respons	1.35798654
44	MP0005310_abnormal_salivary_gland	1.35300713
45	MP0005075_abnormal_melanosome_morpholog	1.34983833
46	MP0002736_abnormal_nociception_after	1.31490110
47	MP0002006_tumorigenesis	1.30875327
48	MP0009333_abnormal_splenocyte_physiolog	1.29515218
49	MP0002405_respiratory_system_inflammati	1.28952388
50	MP0004147_increased_porphyrin_level	1.25986911
51	MP0003866_abnormal_defecation	1.25767478
52	MP0003172_abnormal_lysosome_physiology	1.25280663
53	MP0001986_abnormal_taste_sensitivity	1.24639629
54	MP0003787_abnormal_imprinting	1.17964851
55	MP0008872_abnormal_physiological_respon	1.16857001
56	MP0003880_abnormal_central_pattern	1.15608128
57	MP0003252_abnormal_bile_duct	1.14351886
58	MP0000716_abnormal_immune_system	1.08319947
59	MP0001663_abnormal_digestive_system	1.05423742
60	MP0008469_abnormal_protein_level	1.04891728
61	MP0006292_abnormal_olfactory_placode	1.02481421
62	MP0006072_abnormal_retinal_apoptosis	1.01719806
63	MP0002254_reproductive_system_inflammat	1.00487851
64	MP0005389_reproductive_system_phenotype	0.98877154
65	MP0006036_abnormal_mitochondrial_physio	0.97611866
66	MP0008058_abnormal_DNA_repair	0.96878726
67	MP0004381_abnormal_hair_follicle	0.94893869
68	MP0002398_abnormal_bone_marrow	0.94320585
69	MP0003718_maternal_effect	0.93333364
70	MP0001905_abnormal_dopamine_level	0.91543829
71	MP0004142_abnormal_muscle_tone	0.90389245
72	MP0005551_abnormal_eye_electrophysiolog	0.90223941
73	MP0003186_abnormal_redox_activity	0.88020890
74	MP0002095_abnormal_skin_pigmentation	0.88009268
75	MP0001533_abnormal_skeleton_physiology	0.87080297
76	MP0002837_dystrophic_cardiac_calcinosis	0.86649774
77	MP0005166_decreased_susceptibility_to	0.84856354
78	MP0002928_abnormal_bile_duct	0.84561700
79	MP0001919_abnormal_reproductive_system	0.84009123
80	MP0003763_abnormal_thymus_physiology	0.82860951
81	MP0000689_abnormal_spleen_morphology	0.82629805
82	MP0003075_altered_response_to	0.82573818
83	MP0005464_abnormal_platelet_physiology	0.81970982
84	MP0002429_abnormal_blood_cell	0.81757658
85	MP0006035_abnormal_mitochondrial_morpho	0.78629043
86	MP0008775_abnormal_heart_ventricle	0.77046334
87	MP0002693_abnormal_pancreas_physiology	0.76924086
88	MP0002163_abnormal_gland_morphology	0.72182247
89	MP0002272_abnormal_nervous_system	0.71467436
90	MP0001348_abnormal_lacrimal_gland	0.71343407
91	MP0002735_abnormal_chemical_nociception	0.70314707
92	MP0004885_abnormal_endolymph	0.69452758
93	MP0000465_gastrointestinal_hemorrhage	0.68793436
94	MP0001970_abnormal_pain_threshold	0.68153463
95	MP0000230_abnormal_systemic_arterial	0.66105239
96	MP0002160_abnormal_reproductive_system	0.65964682
97	MP0001501_abnormal_sleep_pattern	0.64970681
98	MP0001440_abnormal_grooming_behavior	0.63807437
99	MP0005636_abnormal_mineral_homeostasis	0.63423447
100	MP0000427_abnormal_hair_cycle	0.63120520

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Stomatitis (HP:0010280)	5.09917814
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.56405774
3	Elevated erythrocyte sedimentation rate (HP:0003565)	3.46247277
4	Pancreatic cysts (HP:0001737)	3.33435727
5	3-Methylglutaconic aciduria (HP:0003535)	3.27553863
6	Autoimmune thrombocytopenia (HP:0001973)	3.27234273
7	Acute necrotizing encephalopathy (HP:0006965)	3.10415914
8	IgG deficiency (HP:0004315)	3.09511909
9	Progressive macrocephaly (HP:0004481)	3.03818971
10	Increased cerebral lipofuscin (HP:0011813)	3.00787701
11	Mitochondrial inheritance (HP:0001427)	2.94609932
12	Increased CSF lactate (HP:0002490)	2.91230738
13	Abnormality of the prostate (HP:0008775)	2.90317026
14	Increased IgM level (HP:0003496)	2.80810979
15	Abolished electroretinogram (ERG) (HP:0000550)	2.75997594
16	Autoimmune hemolytic anemia (HP:0001890)	2.75303336
17	Testicular atrophy (HP:0000029)	2.69303221
18	Abnormal mitochondria in muscle tissue (HP:0008316)	2.68576506
19	Acute encephalopathy (HP:0006846)	2.68337060
20	Nephronophthisis (HP:0000090)	2.65860243
21	Hepatocellular necrosis (HP:0001404)	2.63742734
22	Hemoptysis (HP:0002105)	2.56849040
23	Asplenia (HP:0001746)	2.56812697
24	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.52648703
25	Pancreatic fibrosis (HP:0100732)	2.48712820
26	Hypoproteinemia (HP:0003075)	2.43813739
27	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.43446883
28	Congenital, generalized hypertrichosis (HP:0004540)	2.43425634
29	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.38094825
30	Tubular atrophy (HP:0000092)	2.36628580
31	Pulmonary infiltrates (HP:0002113)	2.35698297
32	Congenital stationary night blindness (HP:0007642)	2.35429716
33	Recurrent cutaneous fungal infections (HP:0011370)	2.34085438
34	Chronic mucocutaneous candidiasis (HP:0002728)	2.34085438
35	Abnormality of the renal medulla (HP:0100957)	2.32531729
36	Adactyly (HP:0009776)	2.31015504
37	Recurrent bacterial skin infections (HP:0005406)	2.30803095
38	Neoplasm of the tracheobronchial system (HP:0100552)	2.29703657
39	Bile duct proliferation (HP:0001408)	2.28061543
40	Abnormal biliary tract physiology (HP:0012439)	2.28061543
41	Aplasia/hypoplasia of the uterus (HP:0008684)	2.26294195
42	Visual hallucinations (HP:0002367)	2.23957795
43	Abnormality of the renal cortex (HP:0011035)	2.23187566
44	Myositis (HP:0100614)	2.23010329
45	Optic neuritis (HP:0100653)	2.22916646
46	Retrobulbar optic neuritis (HP:0100654)	2.22916646
47	Hepatic necrosis (HP:0002605)	2.22474951
48	Abnormality of T cells (HP:0002843)	2.18332664
49	Polydipsia (HP:0001959)	2.17320260
50	Abnormal drinking behavior (HP:0030082)	2.17320260
51	Abnormality of T cell physiology (HP:0011840)	2.16537055
52	Attenuation of retinal blood vessels (HP:0007843)	2.16196476
53	Abnormality of midbrain morphology (HP:0002418)	2.15051828
54	Molar tooth sign on MRI (HP:0002419)	2.15051828
55	Recurrent abscess formation (HP:0002722)	2.13792631
56	Hypoplasia of the uterus (HP:0000013)	2.11526786
57	Type II lissencephaly (HP:0007260)	2.11199069
58	Alveolar cell carcinoma (HP:0006519)	2.09139419
59	Keratoconjunctivitis (HP:0001096)	2.07891532
60	True hermaphroditism (HP:0010459)	2.02837513
61	Abnormality of male internal genitalia (HP:0000022)	2.02207570
62	Methylmalonic aciduria (HP:0012120)	2.01640583
63	Gastrointestinal infarctions (HP:0005244)	2.00997538
64	Medial flaring of the eyebrow (HP:0010747)	2.00820895
65	Increased serum lactate (HP:0002151)	2.00806248
66	Vasculitis (HP:0002633)	2.00503279
67	Recurrent fungal infections (HP:0002841)	2.00496472
68	Optic disc pallor (HP:0000543)	2.00486922
69	Type 2 muscle fiber atrophy (HP:0003554)	2.00210363
70	Renal Fanconi syndrome (HP:0001994)	1.98700864
71	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.94537090
72	Methylmalonic acidemia (HP:0002912)	1.94161622
73	Exertional dyspnea (HP:0002875)	1.93805963
74	Increased hepatocellular lipid droplets (HP:0006565)	1.93715670
75	Decreased circulating renin level (HP:0003351)	1.92667990
76	Cerebellar dysplasia (HP:0007033)	1.90715802
77	Panhypogammaglobulinemia (HP:0003139)	1.90323286
78	Cerebral edema (HP:0002181)	1.88589485
79	Abnormality of T cell number (HP:0011839)	1.87159139
80	Aplastic anemia (HP:0001915)	1.82663758
81	Cerebral hemorrhage (HP:0001342)	1.82268933
82	Absent thumb (HP:0009777)	1.81984190
83	Lipid accumulation in hepatocytes (HP:0006561)	1.81769271
84	Stenosis of the external auditory canal (HP:0000402)	1.81273949
85	Mediastinal lymphadenopathy (HP:0100721)	1.80786050
86	Reticulocytopenia (HP:0001896)	1.78209749
87	Recurrent skin infections (HP:0001581)	1.77202370
88	Hyperglycinemia (HP:0002154)	1.76541753
89	Hypothermia (HP:0002045)	1.75662565
90	Orchitis (HP:0100796)	1.75190007
91	Gangrene (HP:0100758)	1.72379993
92	Supernumerary spleens (HP:0009799)	1.71477197
93	Tubulointerstitial abnormality (HP:0001969)	1.71415843
94	Cleft eyelid (HP:0000625)	1.70766562
95	Neutropenia (HP:0001875)	1.70740280
96	Polyuria (HP:0000103)	1.69318325
97	Lactic acidosis (HP:0003128)	1.69146462
98	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.69034089
99	Chest pain (HP:0100749)	1.68873548
100	Spontaneous abortion (HP:0005268)	1.68464950

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.51008625
2	NUAK1	3.28179315
3	TAOK3	3.11270834
4	MAP4K2	2.80294538
5	PINK1	2.60280293
6	TXK	2.48156090
7	TIE1	2.31890418
8	TEC	2.17492796
9	FES	2.13472254
10	ADRBK2	2.11994010
11	MST4	2.10873987
12	MAP3K12	2.10395072
13	EIF2AK3	2.04422239
14	STK39	2.03193759
15	WNK4	1.92321587
16	OXSR1	1.89208680
17	IKBKB	1.87890660
18	GRK1	1.87115432
19	MAP4K1	1.83300567
20	BMPR2	1.76044404
21	TLK1	1.59294009
22	KIT	1.56235647
23	RIPK4	1.49775727
24	BTK	1.47358147
25	ITK	1.40722366
26	LYN	1.29479646
27	SYK	1.27680842
28	PIK3CG	1.20942737
29	PTK2B	1.16694050
30	MAP3K14	1.11830091
31	CSF1R	1.10608656
32	FLT3	1.10567709
33	WNK1	1.08117668
34	CDK19	1.06682806
35	MKNK1	1.06442843
36	IRAK4	1.06088262
37	BCKDK	1.04225703
38	TNK2	1.01298068
39	BLK	1.00691380
40	ZAK	0.95995264
41	LCK	0.90477770
42	CHUK	0.90283554
43	JAK3	0.90049688
44	IKBKE	0.89114198
45	CSK	0.88828279
46	MYLK	0.87675484
47	TGFBR2	0.87304458
48	MAP3K13	0.85993489
49	STK16	0.85797182
50	GRK6	0.85543150
51	PLK2	0.84600558
52	DAPK2	0.84486029
53	GRK7	0.83451194
54	BMPR1B	0.82729917
55	VRK2	0.81969548
56	MUSK	0.80353904
57	RPS6KA5	0.74320268
58	INSRR	0.73437094
59	HCK	0.69848464
60	ADRBK1	0.66984950
61	PRKCQ	0.66069774
62	MAPKAPK5	0.65286743
63	GRK5	0.63913390
64	EPHA3	0.62703161
65	FGFR2	0.61103444
66	NEK1	0.60654287
67	ACVR1B	0.59111798
68	MARK3	0.58145549
69	NME2	0.58034535
70	IRAK1	0.56826599
71	DYRK2	0.54661895
72	MATK	0.54635393
73	TNIK	0.54100955
74	ABL1	0.52740457
75	IGF1R	0.50213272
76	EIF2AK1	0.49984517
77	PHKG1	0.49559108
78	PHKG2	0.49559108
79	MAP2K6	0.49243575
80	STK11	0.48408845
81	CAMKK2	0.47131470
82	PAK3	0.45887453
83	TRPM7	0.44867573
84	EGFR	0.42550656
85	FGFR3	0.41326965
86	CSNK1G2	0.40892654
87	PLK3	0.40566958
88	TRIM28	0.40271781
89	PRKCD	0.38805113
90	VRK1	0.38407845
91	MINK1	0.37861065
92	JAK2	0.37534838
93	WNK3	0.37046793
94	TAF1	0.36538530
95	PRKG1	0.36072266
96	PIM1	0.35882538
97	PRKCE	0.35531675
98	PIK3CA	0.35401256
99	PRKACA	0.34560734
100	DAPK3	0.33821591

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.47163841
2	Allograft rejection_Homo sapiens_hsa05330	4.62243086
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.18306391
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.11350029
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.79568590
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.46184117
7	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.95821706
8	Caffeine metabolism_Homo sapiens_hsa00232	2.74556466
9	Staphylococcus aureus infection_Homo sapiens_hsa05150	2.33115672
10	Rheumatoid arthritis_Homo sapiens_hsa05323	2.31941022
11	Proteasome_Homo sapiens_hsa03050	2.13344933
12	Antigen processing and presentation_Homo sapiens_hsa04612	2.04771309
13	Leishmaniasis_Homo sapiens_hsa05140	2.03622064
14	Oxidative phosphorylation_Homo sapiens_hsa00190	1.77050573
15	Protein export_Homo sapiens_hsa03060	1.69745733
16	Ribosome_Homo sapiens_hsa03010	1.69391239
17	Phototransduction_Homo sapiens_hsa04744	1.67908740
18	Viral myocarditis_Homo sapiens_hsa05416	1.66987399
19	Parkinsons disease_Homo sapiens_hsa05012	1.39735943
20	RNA polymerase_Homo sapiens_hsa03020	1.37940023
21	Primary immunodeficiency_Homo sapiens_hsa05340	1.37095467
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.36962146
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.34248259
24	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.23924531
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.23744066
26	Nitrogen metabolism_Homo sapiens_hsa00910	1.15162085
27	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.13592158
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.11832054
29	NF-kappa B signaling pathway_Homo sapiens_hsa04064	1.05353229
30	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	1.02217207
31	Regulation of autophagy_Homo sapiens_hsa04140	0.95645592
32	Ether lipid metabolism_Homo sapiens_hsa00565	0.93857207
33	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.93810205
34	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.93541638
35	Toxoplasmosis_Homo sapiens_hsa05145	0.92794983
36	RNA degradation_Homo sapiens_hsa03018	0.91815455
37	Tuberculosis_Homo sapiens_hsa05152	0.91704502
38	Tryptophan metabolism_Homo sapiens_hsa00380	0.90411109
39	Homologous recombination_Homo sapiens_hsa03440	0.88058287
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.85303619
41	Propanoate metabolism_Homo sapiens_hsa00640	0.84215301
42	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.82744490
43	Herpes simplex infection_Homo sapiens_hsa05168	0.76164918
44	Huntingtons disease_Homo sapiens_hsa05016	0.74568218
45	Alzheimers disease_Homo sapiens_hsa05010	0.73751944
46	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.73534714
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.71692396
48	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.70428814
49	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.68774857
50	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.68555819
51	Influenza A_Homo sapiens_hsa05164	0.67790923
52	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.66962146
53	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.64389428
54	Basal transcription factors_Homo sapiens_hsa03022	0.63967945
55	Phagosome_Homo sapiens_hsa04145	0.60591542
56	African trypanosomiasis_Homo sapiens_hsa05143	0.59930513
57	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.59856402
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.58821420
59	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.57221902
60	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.56882341
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.55397011
62	One carbon pool by folate_Homo sapiens_hsa00670	0.54148565
63	Malaria_Homo sapiens_hsa05144	0.53987820
64	Legionellosis_Homo sapiens_hsa05134	0.52936002
65	Measles_Homo sapiens_hsa05162	0.51714823
66	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51120923
67	Cardiac muscle contraction_Homo sapiens_hsa04260	0.50170722
68	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.49529879
69	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.49511917
70	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.46733088
71	Salivary secretion_Homo sapiens_hsa04970	0.43307702
72	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43182899
73	Chemical carcinogenesis_Homo sapiens_hsa05204	0.41665342
74	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.41026848
75	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40094347
76	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40021691
77	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.39113497
78	Peroxisome_Homo sapiens_hsa04146	0.38779320
79	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.37515087
80	RNA transport_Homo sapiens_hsa03013	0.32447609
81	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.32330574
82	Purine metabolism_Homo sapiens_hsa00230	0.32001143
83	Osteoclast differentiation_Homo sapiens_hsa04380	0.30227427
84	Olfactory transduction_Homo sapiens_hsa04740	0.28618680
85	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.27796861
86	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.27356445
87	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.27204823
88	Pyrimidine metabolism_Homo sapiens_hsa00240	0.26130681
89	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.24035467
90	Glycerolipid metabolism_Homo sapiens_hsa00561	0.20670885
91	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.20609306
92	Non-homologous end-joining_Homo sapiens_hsa03450	0.20422440
93	Serotonergic synapse_Homo sapiens_hsa04726	0.19268997
94	TNF signaling pathway_Homo sapiens_hsa04668	0.19129249
95	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.19059054
96	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.18666315
97	Metabolic pathways_Homo sapiens_hsa01100	0.16490275
98	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16388726
99	Retinol metabolism_Homo sapiens_hsa00830	0.15612416
100	beta-Alanine metabolism_Homo sapiens_hsa00410	0.15360523

RPL7P18

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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