RPL7P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.17880377
2DNA deamination (GO:0045006)6.69177479
3cytidine metabolic process (GO:0046087)5.99464063
4cytidine catabolic process (GO:0006216)5.99464063
5cytidine deamination (GO:0009972)5.99464063
6ribosomal small subunit assembly (GO:0000028)5.95938504
7ribosomal small subunit biogenesis (GO:0042274)5.85067120
8pyrimidine ribonucleoside catabolic process (GO:0046133)5.12805864
9ncRNA 3-end processing (GO:0043628)4.76845366
10viral transcription (GO:0019083)4.52503627
11protein neddylation (GO:0045116)4.42570083
12positive regulation of natural killer cell mediated immunity (GO:0002717)4.31511754
13positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.28786400
14translational termination (GO:0006415)4.25520489
15positive thymic T cell selection (GO:0045059)4.22184128
16positive T cell selection (GO:0043368)4.21801259
17translational elongation (GO:0006414)3.89241390
18regulation of natural killer cell mediated immunity (GO:0002715)3.88102726
19regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.88102726
20sequestering of actin monomers (GO:0042989)3.83838452
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76678481
22regulation of regulatory T cell differentiation (GO:0045589)3.70442533
23positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.69488104
24negative regulation of T cell apoptotic process (GO:0070233)3.68318856
25T cell migration (GO:0072678)3.66065679
26negative regulation by host of viral transcription (GO:0043922)3.60554846
27negative T cell selection (GO:0043383)3.59311123
28behavioral response to nicotine (GO:0035095)3.57270420
29SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.49930126
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.48305212
31mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.45971178
32regulation of leukocyte mediated cytotoxicity (GO:0001910)3.43712825
33Arp2/3 complex-mediated actin nucleation (GO:0034314)3.43612851
34protein targeting to ER (GO:0045047)3.42182901
35cotranslational protein targeting to membrane (GO:0006613)3.40706739
36positive regulation of calcium-mediated signaling (GO:0050850)3.40228703
37ribosomal large subunit biogenesis (GO:0042273)3.40125309
38positive regulation of T cell mediated cytotoxicity (GO:0001916)3.36265617
39cytolysis (GO:0019835)3.34033931
40actin nucleation (GO:0045010)3.33411408
41mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30499685
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.30253764
43ATP synthesis coupled proton transport (GO:0015986)3.30253764
44establishment of protein localization to endoplasmic reticulum (GO:0072599)3.25935456
45positive regulation of cell killing (GO:0031343)3.25921848
46protein localization to endoplasmic reticulum (GO:0070972)3.25591319
47regulation of B cell receptor signaling pathway (GO:0050855)3.25375534
48viral life cycle (GO:0019058)3.19949657
49regulation of activation of Janus kinase activity (GO:0010533)3.12765213
50cellular protein complex disassembly (GO:0043624)3.10336953
51thymic T cell selection (GO:0045061)3.07285477
52regulation of cell killing (GO:0031341)3.06762440
53pyrimidine nucleoside catabolic process (GO:0046135)3.06386967
54regulation of gamma-delta T cell differentiation (GO:0045586)3.04399957
55regulation of T cell mediated cytotoxicity (GO:0001914)3.01295876
56regulation of T cell receptor signaling pathway (GO:0050856)2.97804080
57negative regulation of viral genome replication (GO:0045071)2.95047346
58positive regulation of gamma-delta T cell activation (GO:0046645)2.91760331
59T cell receptor signaling pathway (GO:0050852)2.90674810
60cellular response to interleukin-15 (GO:0071350)2.89635655
61negative regulation of mast cell activation (GO:0033004)2.88401147
62respiratory electron transport chain (GO:0022904)2.87434688
63mast cell activation involved in immune response (GO:0002279)2.86545982
64mast cell degranulation (GO:0043303)2.86545982
65electron transport chain (GO:0022900)2.84151492
66regulation of interleukin-12 biosynthetic process (GO:0045075)2.82482609
67interferon-gamma production (GO:0032609)2.79288640
68negative thymic T cell selection (GO:0045060)2.78482299
69activated T cell proliferation (GO:0050798)2.77304917
70iron-sulfur cluster assembly (GO:0016226)2.76454342
71metallo-sulfur cluster assembly (GO:0031163)2.76454342
72positive regulation of T cell differentiation in thymus (GO:0033089)2.74570663
73nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.73862510
74positive regulation of interleukin-8 secretion (GO:2000484)2.73506102
75regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.72645772
76positive regulation of tolerance induction (GO:0002645)2.69202445
77positive regulation of T cell apoptotic process (GO:0070234)2.68442753
78regulation of T cell apoptotic process (GO:0070232)2.67933818
79negative regulation of stress fiber assembly (GO:0051497)2.67109153
80positive regulation of alpha-beta T cell proliferation (GO:0046641)2.65825363
81negative regulation of lymphocyte apoptotic process (GO:0070229)2.65073176
82mast cell activation (GO:0045576)2.64085497
83T cell selection (GO:0045058)2.58042803
84maturation of SSU-rRNA (GO:0030490)2.57343666
85eosinophil chemotaxis (GO:0048245)2.56164600
86regulation of rhodopsin mediated signaling pathway (GO:0022400)2.54962967
87deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.53999687
88kynurenine metabolic process (GO:0070189)2.53817093
89antigen receptor-mediated signaling pathway (GO:0050851)2.52902841
90ribonucleoprotein complex biogenesis (GO:0022613)2.52087301
91rhodopsin mediated signaling pathway (GO:0016056)2.50035214
92regulation of T cell tolerance induction (GO:0002664)2.48980209
93positive regulation of uterine smooth muscle contraction (GO:0070474)2.48182219
94positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.47961403
95aggressive behavior (GO:0002118)2.47438078
96regulation of interleukin-8 secretion (GO:2000482)2.47161884
97translational initiation (GO:0006413)2.47133258
98negative regulation of actin filament bundle assembly (GO:0032232)2.45280451
99negative regulation of oxidoreductase activity (GO:0051354)2.44018898
100negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.43655945

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.68003402
2IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.21494810
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.13982428
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98281608
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65440085
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.58120499
7VDR_22108803_ChIP-Seq_LS180_Human2.53846616
8EZH2_22144423_ChIP-Seq_EOC_Human2.51813402
9RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50641771
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34037459
11LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.12370712
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.98002419
13ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93874461
14IRF8_21731497_ChIP-ChIP_J774_Mouse1.88918358
15RUNX_20019798_ChIP-Seq_JUKART_Human1.88911043
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.83349851
17NOTCH1_21737748_ChIP-Seq_TLL_Human1.77152532
18ZNF274_21170338_ChIP-Seq_K562_Hela1.75455911
19BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74510336
20MYB_26560356_Chip-Seq_TH2_Human1.73365548
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70949162
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.63110734
23FLI1_27457419_Chip-Seq_LIVER_Mouse1.61685652
24NANOG_20526341_ChIP-Seq_ESCs_Human1.61578626
25HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.56435198
26NCOR_22424771_ChIP-Seq_293T_Human1.52334330
27EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.50430616
28RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49092442
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.48564817
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.47818302
31JARID2_20064375_ChIP-Seq_MESCs_Mouse1.47503060
32GATA3_27048872_Chip-Seq_THYMUS_Human1.47211272
33FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.45087965
34EST1_17652178_ChIP-ChIP_JURKAT_Human1.42681009
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41965398
36EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.33435049
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33263830
38JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33141593
39TP53_22573176_ChIP-Seq_HFKS_Human1.32665553
40IRF1_19129219_ChIP-ChIP_H3396_Human1.31344140
41FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31065369
42FOXA1_25329375_ChIP-Seq_VCAP_Human1.31065369
43BCL6_27268052_Chip-Seq_Bcells_Human1.29201532
44GATA3_21878914_ChIP-Seq_MCF-7_Human1.28803459
45PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.28457395
46IGF1R_20145208_ChIP-Seq_DFB_Human1.27731701
47EZH2_27294783_Chip-Seq_ESCs_Mouse1.27311944
48STAT4_19710469_ChIP-ChIP_TH1__Mouse1.27038525
49CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.26721906
50TAF2_19829295_ChIP-Seq_ESCs_Human1.26209787
51SUZ12_27294783_Chip-Seq_ESCs_Mouse1.25943104
52RNF2_27304074_Chip-Seq_NSC_Mouse1.25925863
53PCGF2_27294783_Chip-Seq_ESCs_Mouse1.25258208
54EGR1_19032775_ChIP-ChIP_M12_Human1.25123202
55SOX2_19829295_ChIP-Seq_ESCs_Human1.23525259
56NANOG_19829295_ChIP-Seq_ESCs_Human1.23525259
57EZH2_27304074_Chip-Seq_ESCs_Mouse1.23012417
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22727404
59GATA3_26560356_Chip-Seq_TH2_Human1.22235035
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.21819462
61AR_20517297_ChIP-Seq_VCAP_Human1.20245378
62FUS_26573619_Chip-Seq_HEK293_Human1.18398513
63MYC_19829295_ChIP-Seq_ESCs_Human1.18355348
64CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15996530
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.15664401
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15472087
67SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.15304097
68TDRD3_21172665_ChIP-Seq_MCF-7_Human1.15176811
69TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14919449
70HTT_18923047_ChIP-ChIP_STHdh_Human1.14736034
71CBP_20019798_ChIP-Seq_JUKART_Human1.12061516
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.12061516
73BCAT_22108803_ChIP-Seq_LS180_Human1.12030797
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11691727
75AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11395750
76VDR_23849224_ChIP-Seq_CD4+_Human1.10947660
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.10943860
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10009952
79EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.08398364
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06960390
81AR_21572438_ChIP-Seq_LNCaP_Human1.03772720
82ER_23166858_ChIP-Seq_MCF-7_Human1.03563549
83MYB_26560356_Chip-Seq_TH1_Human1.03182990
84P300_19829295_ChIP-Seq_ESCs_Human1.02990430
85GBX2_23144817_ChIP-Seq_PC3_Human1.02859255
86ERG_20517297_ChIP-Seq_VCAP_Human1.00451984
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.00322650
88PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.99329796
89MYC_18940864_ChIP-ChIP_HL60_Human0.99271157
90STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98987190
91FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97265724
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96883714
93E2F1_20622854_ChIP-Seq_HELA_Human0.96558110
94ERA_21632823_ChIP-Seq_H3396_Human0.96310158
95ETS1_20019798_ChIP-Seq_JURKAT_Human0.95394877
96SA1_27219007_Chip-Seq_Bcells_Human0.95173309
97GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.94758676
98ELF1_20517297_ChIP-Seq_JURKAT_Human0.94254777
99PCGF2_27294783_Chip-Seq_NPCs_Mouse0.93463326
100CTCF_20526341_ChIP-Seq_ESCs_Human0.93072986

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.71711812
2MP0006292_abnormal_olfactory_placode3.62847333
3MP0009379_abnormal_foot_pigmentation3.37995137
4MP0006082_CNS_inflammation3.23839305
5MP0001873_stomach_inflammation3.17573419
6MP0009785_altered_susceptibility_to2.71573554
7MP0003763_abnormal_thymus_physiology2.42905498
8MP0004510_myositis2.41826602
9MP0003879_abnormal_hair_cell2.30928433
10MP0009333_abnormal_splenocyte_physiolog2.15049970
11MP0001800_abnormal_humoral_immune2.04701390
12MP0002933_joint_inflammation1.94403805
13MP0005000_abnormal_immune_tolerance1.90099374
14MP0003878_abnormal_ear_physiology1.89122254
15MP0005377_hearing/vestibular/ear_phenot1.89122254
16MP0005075_abnormal_melanosome_morpholog1.87136865
17MP0001835_abnormal_antigen_presentation1.76026359
18MP0003866_abnormal_defecation1.71006900
19MP0002723_abnormal_immune_serum1.68265590
20MP0005025_abnormal_response_to1.68194356
21MP0002876_abnormal_thyroid_physiology1.67853307
22MP0005646_abnormal_pituitary_gland1.65410131
23MP0002420_abnormal_adaptive_immunity1.64369906
24MP0002138_abnormal_hepatobiliary_system1.63071578
25MP0001905_abnormal_dopamine_level1.59161541
26MP0001819_abnormal_immune_cell1.59075796
27MP0003646_muscle_fatigue1.57251755
28MP0005551_abnormal_eye_electrophysiolog1.56127150
29MP0008877_abnormal_DNA_methylation1.55003648
30MP0005645_abnormal_hypothalamus_physiol1.50712431
31MP0001986_abnormal_taste_sensitivity1.50063714
32MP0002837_dystrophic_cardiac_calcinosis1.48345181
33MP0006276_abnormal_autonomic_nervous1.47224239
34MP0005174_abnormal_tail_pigmentation1.46818914
35MP0002148_abnormal_hypersensitivity_rea1.44394922
36MP0002452_abnormal_antigen_presenting1.44367998
37MP0002405_respiratory_system_inflammati1.43178470
38MP0008872_abnormal_physiological_respon1.41943272
39MP0002166_altered_tumor_susceptibility1.41151221
40MP0001968_abnormal_touch/_nociception1.39979002
41MP0005387_immune_system_phenotype1.35742870
42MP0001790_abnormal_immune_system1.35742870
43MP0002638_abnormal_pupillary_reflex1.34914052
44MP0003880_abnormal_central_pattern1.34873344
45MP0003121_genomic_imprinting1.31196823
46MP0004147_increased_porphyrin_level1.26369090
47MP0000716_abnormal_immune_system1.21310604
48MP0010155_abnormal_intestine_physiology1.21050833
49MP0004885_abnormal_endolymph1.20829360
50MP0002102_abnormal_ear_morphology1.19925653
51MP0002163_abnormal_gland_morphology1.19815169
52MP0002006_tumorigenesis1.19035093
53MP0001663_abnormal_digestive_system1.18535846
54MP0002736_abnormal_nociception_after1.16203765
55MP0004145_abnormal_muscle_electrophysio1.16132608
56MP0006072_abnormal_retinal_apoptosis1.15324825
57MP0002398_abnormal_bone_marrow1.14000269
58MP0000703_abnormal_thymus_morphology1.13748901
59MP0002160_abnormal_reproductive_system1.13060777
60MP0001727_abnormal_embryo_implantation1.11190976
61MP0000689_abnormal_spleen_morphology1.08752253
62MP0003283_abnormal_digestive_organ1.08659147
63MP0008875_abnormal_xenobiotic_pharmacok1.08113327
64MP0005389_reproductive_system_phenotype1.07960328
65MP0005423_abnormal_somatic_nervous1.07822332
66MP0003787_abnormal_imprinting1.06676243
67MP0003195_calcinosis1.05238959
68MP0002419_abnormal_innate_immunity1.04538964
69MP0003724_increased_susceptibility_to1.04200432
70MP0001845_abnormal_inflammatory_respons1.03158794
71MP0000685_abnormal_immune_system1.02766177
72MP0000372_irregular_coat_pigmentation1.01423350
73MP0002095_abnormal_skin_pigmentation0.99269548
74MP0002733_abnormal_thermal_nociception0.99130336
75MP0010386_abnormal_urinary_bladder0.97187603
76MP0004130_abnormal_muscle_cell0.97121828
77MP0001485_abnormal_pinna_reflex0.96285856
78MP0002722_abnormal_immune_system0.95535248
79MP0004142_abnormal_muscle_tone0.95059279
80MP0003011_delayed_dark_adaptation0.94925297
81MP0002272_abnormal_nervous_system0.94321396
82MP0001970_abnormal_pain_threshold0.93569085
83MP0009745_abnormal_behavioral_response0.92579281
84MP0001963_abnormal_hearing_physiology0.91145408
85MP0004742_abnormal_vestibular_system0.89142811
86MP0001533_abnormal_skeleton_physiology0.88340623
87MP0002234_abnormal_pharynx_morphology0.86543447
88MP0001440_abnormal_grooming_behavior0.85508567
89MP0001919_abnormal_reproductive_system0.85314832
90MP0008469_abnormal_protein_level0.84685407
91MP0002429_abnormal_blood_cell0.84045515
92MP0005410_abnormal_fertilization0.83705913
93MP0005253_abnormal_eye_physiology0.82760940
94MP0003436_decreased_susceptibility_to0.82209675
95MP0001501_abnormal_sleep_pattern0.80879094
96MP0005084_abnormal_gallbladder_morpholo0.80778408
97MP0000026_abnormal_inner_ear0.78582046
98MP0004947_skin_inflammation0.78556583
99MP0003938_abnormal_ear_development0.77271357
100MP0003137_abnormal_impulse_conducting0.73073706

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)5.09777203
2Abnormality of macular pigmentation (HP:0008002)4.76850158
3Attenuation of retinal blood vessels (HP:0007843)4.54776038
4Constricted visual fields (HP:0001133)4.52535045
5Severe combined immunodeficiency (HP:0004430)4.45200761
6Congenital stationary night blindness (HP:0007642)4.27846585
7Autoimmune hemolytic anemia (HP:0001890)4.09223657
8Decreased electroretinogram (ERG) amplitude (HP:0000654)4.02668818
9Abnormal rod and cone electroretinograms (HP:0008323)3.92535580
10Thyroiditis (HP:0100646)3.80581707
11Striae distensae (HP:0001065)3.62061760
12Abnormality of B cell number (HP:0010975)3.47191514
13IgG deficiency (HP:0004315)3.43844009
14Combined immunodeficiency (HP:0005387)3.40514639
15Elevated erythrocyte sedimentation rate (HP:0003565)3.40385689
16Decreased central vision (HP:0007663)3.32770577
17Abnormality of T cell number (HP:0011839)3.30937913
183-Methylglutaconic aciduria (HP:0003535)3.29686064
19Aplastic anemia (HP:0001915)3.27840118
20Abnormality of cells of the erythroid lineage (HP:0012130)3.17389768
21T lymphocytopenia (HP:0005403)3.10424659
22Abnormality of eosinophils (HP:0001879)3.02570983
23Optic disc pallor (HP:0000543)2.98563563
24Round ear (HP:0100830)2.96644244
25Hypoproteinemia (HP:0003075)2.88551962
26Abnormal number of erythroid precursors (HP:0012131)2.85517929
27Severe visual impairment (HP:0001141)2.83941884
28Volvulus (HP:0002580)2.81260440
29Increased IgM level (HP:0003496)2.76943428
30Cone-rod dystrophy (HP:0000548)2.70548863
31Pancreatic cysts (HP:0001737)2.70392517
32Pancreatic fibrosis (HP:0100732)2.66744775
33Abolished electroretinogram (ERG) (HP:0000550)2.62050894
34Metaphyseal cupping (HP:0003021)2.60970523
35Cupped ribs (HP:0000887)2.58468877
36B lymphocytopenia (HP:0010976)2.52569497
37Abnormality of the prostate (HP:0008775)2.50919903
38True hermaphroditism (HP:0010459)2.48808819
39Mitochondrial inheritance (HP:0001427)2.46112807
40Abnormality of midbrain morphology (HP:0002418)2.41514550
41Molar tooth sign on MRI (HP:0002419)2.41514550
42Autoimmune thrombocytopenia (HP:0001973)2.39709469
43Abnormality of T cells (HP:0002843)2.25702861
44Acute necrotizing encephalopathy (HP:0006965)2.20440838
45Recurrent otitis media (HP:0000403)2.18328648
46Pendular nystagmus (HP:0012043)2.16216884
47Congenital, generalized hypertrichosis (HP:0004540)2.16047246
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.14920370
49Absent/shortened dynein arms (HP:0200106)2.14920370
50Eosinophilia (HP:0001880)2.12611096
51Stomach cancer (HP:0012126)2.09334171
52Leukocytosis (HP:0001974)2.08406880
53Asplenia (HP:0001746)2.08402532
54Methylmalonic acidemia (HP:0002912)2.08363179
55Stenosis of the external auditory canal (HP:0000402)2.08093606
56Cerebral palsy (HP:0100021)2.05222087
57Mesangial abnormality (HP:0001966)2.04288500
58Toxemia of pregnancy (HP:0100603)2.02079611
59Aplasia/Hypoplasia of the spleen (HP:0010451)2.01948310
60Hemiplegia (HP:0002301)2.00871643
61Absent thumb (HP:0009777)2.00247164
62IgM deficiency (HP:0002850)1.99741057
63Macrocytic anemia (HP:0001972)1.97275816
64Agammaglobulinemia (HP:0004432)1.95243471
65Hyperglycinemia (HP:0002154)1.94225037
66Polydipsia (HP:0001959)1.93458451
67Abnormal drinking behavior (HP:0030082)1.93458451
68Abnormal mitochondria in muscle tissue (HP:0008316)1.92912734
69Keratoconus (HP:0000563)1.92538479
70Increased corneal curvature (HP:0100692)1.92538479
71Increased CSF lactate (HP:0002490)1.92323790
72Reticulocytopenia (HP:0001896)1.90961932
73Ketosis (HP:0001946)1.90822880
74Acute encephalopathy (HP:0006846)1.90681495
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.89683185
76Lymphopenia (HP:0001888)1.89668014
77Sclerocornea (HP:0000647)1.88586632
78Encephalitis (HP:0002383)1.86962621
79Abnormality of cells of the lymphoid lineage (HP:0012140)1.86673945
80Abnormality of the phalanges of the 5th finger (HP:0004213)1.85650246
81Bile duct proliferation (HP:0001408)1.84605048
82Abnormal biliary tract physiology (HP:0012439)1.84605048
83Progressive macrocephaly (HP:0004481)1.81959457
84Abnormality of the renal cortex (HP:0011035)1.81914631
85Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81848153
86Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81848153
87Panhypogammaglobulinemia (HP:0003139)1.81551719
88Cystic liver disease (HP:0006706)1.80314025
89Concave nail (HP:0001598)1.80210706
90Hepatocellular necrosis (HP:0001404)1.80008293
91Prostate neoplasm (HP:0100787)1.79551463
92Type 2 muscle fiber atrophy (HP:0003554)1.79547778
93Abnormal delayed hypersensitivity skin test (HP:0002963)1.76776784
94Abnormality of the phalanges of the 2nd finger (HP:0009541)1.75296625
95Hematochezia (HP:0002573)1.75242210
96Amyotrophic lateral sclerosis (HP:0007354)1.75020902
97Cerebral edema (HP:0002181)1.72608980
98Abnormal albumin level (HP:0012116)1.72444648
99Hypoalbuminemia (HP:0003073)1.72444648
100Myotonia (HP:0002486)1.71853414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.53394168
2TXK4.42773853
3KDR4.09586751
4KIT4.07703396
5BCKDK3.12885457
6CDK193.10208331
7TEC2.60443868
8FES2.56549538
9ZAK2.48144401
10GRK12.22481921
11ADRBK22.16276734
12MUSK2.15236073
13ITK2.10665516
14SYK2.08062187
15PIK3CA2.01264028
16FRK1.97945248
17MAP4K11.78842542
18MAP4K21.75120207
19TAOK31.68725604
20VRK21.67092324
21PASK1.65793779
22PINK11.58388433
23TRPM71.51848340
24GRK61.38428754
25TLK11.35333413
26IKBKE1.32004752
27IKBKB1.27739365
28LIMK11.27042368
29MAP3K111.22306991
30CSK1.20018620
31BTK1.14714787
32PRKCQ1.14379632
33LCK1.14168618
34STK161.10537732
35SIK21.10178751
36GRK71.09542047
37BMPR1B1.06088667
38TIE11.03494100
39WNK31.02495340
40CSF1R1.01925066
41JAK31.01421881
42WNK40.99333634
43VRK10.98839687
44EPHA40.91079195
45SCYL20.89572685
46LYN0.85169975
47TBK10.84487904
48TESK10.83487798
49ZAP700.83050540
50INSRR0.81939752
51ADRBK10.80930994
52OXSR10.75590398
53NUAK10.74756698
54OBSCN0.69141942
55TNK20.65076897
56IGF1R0.62988142
57CAMKK10.62246806
58TYRO30.55779236
59FYN0.55072570
60CDK30.53511900
61PRKCA0.52635814
62PRKACA0.52478896
63GRK50.52353147
64INSR0.51760351
65MAPK130.49052751
66RPS6KA50.45268263
67ABL10.44327816
68MAPKAPK30.43941133
69HCK0.42940905
70PRKCH0.42764818
71ABL20.42080043
72ACVR1B0.41569713
73PIK3CG0.41246710
74RPS6KA60.40471502
75MATK0.40325866
76PHKG20.38857714
77PHKG10.38857714
78DYRK20.38597133
79PRKCD0.38301071
80RPS6KB20.38228728
81LRRK20.37888779
82MAPK150.37470594
83PRKCE0.33009911
84PIM10.31930327
85PRKCG0.30900023
86SRC0.30143233
87MAP3K140.29433612
88PRKACG0.29432012
89NEK20.29087227
90CAMKK20.28105244
91ILK0.28043483
92CAMK2A0.27079813
93RPS6KC10.26575273
94RPS6KL10.26575273
95CSNK1D0.26010032
96FLT30.25898062
97MAP2K20.25302893
98MAP2K60.24824974
99PRKCB0.24146815
100AURKA0.24018189

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.73102557
2Ribosome_Homo sapiens_hsa030103.95130053
3Oxidative phosphorylation_Homo sapiens_hsa001903.39486454
4Graft-versus-host disease_Homo sapiens_hsa053322.85103284
5Parkinsons disease_Homo sapiens_hsa050122.71068723
6Phototransduction_Homo sapiens_hsa047442.61525771
7Allograft rejection_Homo sapiens_hsa053302.52715114
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.45868677
9Autoimmune thyroid disease_Homo sapiens_hsa053202.35099051
10Hematopoietic cell lineage_Homo sapiens_hsa046402.30070151
11Antigen processing and presentation_Homo sapiens_hsa046122.27108156
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.20628170
13Type I diabetes mellitus_Homo sapiens_hsa049402.11318505
14Proteasome_Homo sapiens_hsa030502.10115824
15Alzheimers disease_Homo sapiens_hsa050101.92714037
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87852690
17Cardiac muscle contraction_Homo sapiens_hsa042601.83009901
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80675835
19T cell receptor signaling pathway_Homo sapiens_hsa046601.79465039
20Caffeine metabolism_Homo sapiens_hsa002321.75698957
21Linoleic acid metabolism_Homo sapiens_hsa005911.70445008
22Huntingtons disease_Homo sapiens_hsa050161.54429992
23Olfactory transduction_Homo sapiens_hsa047401.51790113
24Malaria_Homo sapiens_hsa051441.45436269
25Tryptophan metabolism_Homo sapiens_hsa003801.43742476
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.41474677
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.40882629
28Nitrogen metabolism_Homo sapiens_hsa009101.40078535
29Asthma_Homo sapiens_hsa053101.33667333
30Rheumatoid arthritis_Homo sapiens_hsa053231.33585454
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.29769649
32RNA polymerase_Homo sapiens_hsa030201.28442384
33Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22689765
34Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.18635538
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18423551
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15465763
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13424510
38Arachidonic acid metabolism_Homo sapiens_hsa005901.06764954
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06147635
40Retinol metabolism_Homo sapiens_hsa008301.02183578
41Butanoate metabolism_Homo sapiens_hsa006501.01130834
42Peroxisome_Homo sapiens_hsa041460.96920770
43Measles_Homo sapiens_hsa051620.95798122
44Taste transduction_Homo sapiens_hsa047420.95681883
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.94525884
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.90883220
47Nicotine addiction_Homo sapiens_hsa050330.90155588
48Chemical carcinogenesis_Homo sapiens_hsa052040.85018324
49Systemic lupus erythematosus_Homo sapiens_hsa053220.79949305
50Fat digestion and absorption_Homo sapiens_hsa049750.77801093
51Maturity onset diabetes of the young_Homo sapiens_hsa049500.76905231
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76369067
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75519494
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74656391
55African trypanosomiasis_Homo sapiens_hsa051430.74460840
56Viral myocarditis_Homo sapiens_hsa054160.74322002
57Propanoate metabolism_Homo sapiens_hsa006400.72261583
58Staphylococcus aureus infection_Homo sapiens_hsa051500.71754755
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70135309
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69638353
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66312499
62Purine metabolism_Homo sapiens_hsa002300.64971411
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.63493993
64RNA degradation_Homo sapiens_hsa030180.61518523
65Morphine addiction_Homo sapiens_hsa050320.61206070
66beta-Alanine metabolism_Homo sapiens_hsa004100.57094414
67Ether lipid metabolism_Homo sapiens_hsa005650.56590399
68Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55230320
69Salivary secretion_Homo sapiens_hsa049700.52937494
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52043362
71NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50583786
72Glycerolipid metabolism_Homo sapiens_hsa005610.48559264
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46986640
74Pyrimidine metabolism_Homo sapiens_hsa002400.46537570
75Serotonergic synapse_Homo sapiens_hsa047260.44535391
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43484498
77Calcium signaling pathway_Homo sapiens_hsa040200.41852901
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41517267
79ABC transporters_Homo sapiens_hsa020100.38487720
80Histidine metabolism_Homo sapiens_hsa003400.36815994
81Renin secretion_Homo sapiens_hsa049240.35405502
82Metabolic pathways_Homo sapiens_hsa011000.34727910
83Chemokine signaling pathway_Homo sapiens_hsa040620.28894324
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28365329
85Circadian entrainment_Homo sapiens_hsa047130.27036253
86Alcoholism_Homo sapiens_hsa050340.25800442
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.25322184
88Fatty acid degradation_Homo sapiens_hsa000710.24628795
89Jak-STAT signaling pathway_Homo sapiens_hsa046300.24354113
90Shigellosis_Homo sapiens_hsa051310.23233120
91Salmonella infection_Homo sapiens_hsa051320.22790063
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22091106
93Ovarian steroidogenesis_Homo sapiens_hsa049130.21530927
94Tyrosine metabolism_Homo sapiens_hsa003500.21450246
95Mineral absorption_Homo sapiens_hsa049780.21324749
96Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.21007091
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.20854584
98Toll-like receptor signaling pathway_Homo sapiens_hsa046200.20796951
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20747411
100Protein export_Homo sapiens_hsa030600.20235921

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