RPL7P20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.68397504
2water-soluble vitamin biosynthetic process (GO:0042364)4.21663879
3exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 4.08292453
4energy coupled proton transport, down electrochemical gradient (GO:0015985)4.02238587
5ATP synthesis coupled proton transport (GO:0015986)4.02238587
6regulation of mitotic spindle checkpoint (GO:1903504)4.00456156
7regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.00456156
8rRNA modification (GO:0000154)3.99070537
9nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.97380110
10ribosomal small subunit assembly (GO:0000028)3.92499849
11negative regulation of DNA-dependent DNA replication (GO:2000104)3.73703371
12protein neddylation (GO:0045116)3.72082343
13maturation of 5.8S rRNA (GO:0000460)3.70408835
14transcription elongation from RNA polymerase III promoter (GO:0006385)3.60675300
15termination of RNA polymerase III transcription (GO:0006386)3.60675300
16respiratory chain complex IV assembly (GO:0008535)3.60521118
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60490411
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.57840865
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.56646257
20proteasome assembly (GO:0043248)3.53286462
21behavioral response to nicotine (GO:0035095)3.51577416
22fucose catabolic process (GO:0019317)3.50894452
23L-fucose metabolic process (GO:0042354)3.50894452
24L-fucose catabolic process (GO:0042355)3.50894452
25ribosomal large subunit biogenesis (GO:0042273)3.45681063
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.38802792
27chaperone-mediated protein transport (GO:0072321)3.38542752
28regulation of cellular amino acid metabolic process (GO:0006521)3.37186491
29DNA replication checkpoint (GO:0000076)3.30016203
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.28727215
31signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26417444
32signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26417444
33signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26417444
34cytochrome complex assembly (GO:0017004)3.26406794
35DNA double-strand break processing (GO:0000729)3.25851794
36negative regulation of telomere maintenance (GO:0032205)3.24911620
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.24420142
38negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22532771
39negative regulation of ligase activity (GO:0051352)3.22532771
40RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.21042888
41tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.21042888
42pseudouridine synthesis (GO:0001522)3.19830240
43intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.16955376
44signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.16955376
45regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16601338
46rRNA methylation (GO:0031167)3.16054476
47somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.14468892
48somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.14468892
49isotype switching (GO:0045190)3.14468892
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14197829
51cullin deneddylation (GO:0010388)3.11743898
52signal transduction involved in DNA integrity checkpoint (GO:0072401)3.08440322
53signal transduction involved in DNA damage checkpoint (GO:0072422)3.08440322
54protein complex biogenesis (GO:0070271)3.08347749
55signal transduction involved in cell cycle checkpoint (GO:0072395)3.04102228
56mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.99612133
57kynurenine metabolic process (GO:0070189)2.98674701
58protein deneddylation (GO:0000338)2.98280446
59tryptophan catabolic process (GO:0006569)2.95812529
60indole-containing compound catabolic process (GO:0042436)2.95812529
61indolalkylamine catabolic process (GO:0046218)2.95812529
62somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92030869
63somatic hypermutation of immunoglobulin genes (GO:0016446)2.92030869
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.91494120
65mitochondrial respiratory chain complex I assembly (GO:0032981)2.91494120
66NADH dehydrogenase complex assembly (GO:0010257)2.91494120
67maturation of SSU-rRNA (GO:0030490)2.91412338
68nucleobase biosynthetic process (GO:0046112)2.90255650
69chromatin remodeling at centromere (GO:0031055)2.89397392
70aldehyde catabolic process (GO:0046185)2.86849262
71piRNA metabolic process (GO:0034587)2.86803850
72mitochondrial respiratory chain complex assembly (GO:0033108)2.86466494
73tRNA processing (GO:0008033)2.85817005
74branched-chain amino acid catabolic process (GO:0009083)2.85807034
75rRNA processing (GO:0006364)2.82824776
76rRNA metabolic process (GO:0016072)2.80347591
77negative regulation of B cell apoptotic process (GO:0002903)2.73808643
78anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.72803574
79purine nucleobase biosynthetic process (GO:0009113)2.70758431
80organelle disassembly (GO:1903008)2.68967235
81tRNA metabolic process (GO:0006399)2.68839785
82electron transport chain (GO:0022900)2.65773866
83regulation of helicase activity (GO:0051095)2.63085507
84translation (GO:0006412)2.63058886
85DNA catabolic process, exonucleolytic (GO:0000738)2.62434960
86GTP biosynthetic process (GO:0006183)2.61550800
87positive regulation of prostaglandin secretion (GO:0032308)2.60979321
88mitochondrial RNA metabolic process (GO:0000959)2.60930842
89positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.60921439
90respiratory electron transport chain (GO:0022904)2.60654530
91response to pheromone (GO:0019236)2.60465978
92DNA strand renaturation (GO:0000733)2.58936086
93regulation of immunoglobulin secretion (GO:0051023)2.58219260
94replication fork processing (GO:0031297)2.57077517
95positive regulation of ligase activity (GO:0051351)2.56835833
96protein-cofactor linkage (GO:0018065)2.55855325
97cellular component biogenesis (GO:0044085)2.55326955
98ubiquinone biosynthetic process (GO:0006744)2.54400138
99tryptophan metabolic process (GO:0006568)2.54161233
100DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.52345894

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.87422825
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.29753222
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.83957329
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.47165515
5ZNF274_21170338_ChIP-Seq_K562_Hela3.04858205
6VDR_22108803_ChIP-Seq_LS180_Human3.01878877
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.95985778
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.93767595
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.88061008
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.65702196
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.65014513
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64220444
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.46813217
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.44477018
15VDR_23849224_ChIP-Seq_CD4+_Human2.38361962
16ELK1_19687146_ChIP-ChIP_HELA_Human2.29028936
17E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23283494
18E2F7_22180533_ChIP-Seq_HELA_Human2.23042825
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19249301
20FOXP3_21729870_ChIP-Seq_TREG_Human2.11972728
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.05856081
22EWS_26573619_Chip-Seq_HEK293_Human2.02611018
23IRF1_19129219_ChIP-ChIP_H3396_Human1.98198527
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97610219
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.90886629
26IGF1R_20145208_ChIP-Seq_DFB_Human1.82513732
27CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.81523210
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.79339675
29MYC_18940864_ChIP-ChIP_HL60_Human1.77786476
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76272016
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.70948569
32EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70054511
33MYC_18358816_ChIP-ChIP_MESCs_Mouse1.68497805
34PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66998431
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66640160
36MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55450425
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53470628
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.50831494
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49372046
40FUS_26573619_Chip-Seq_HEK293_Human1.47664702
41PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47304850
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44581528
43TP53_22573176_ChIP-Seq_HFKS_Human1.44063398
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43585731
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.39568049
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37313077
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.34409151
48FOXA1_25329375_ChIP-Seq_VCAP_Human1.31803684
49FOXA1_27270436_Chip-Seq_PROSTATE_Human1.31803684
50P300_19829295_ChIP-Seq_ESCs_Human1.30478877
51TTF2_22483619_ChIP-Seq_HELA_Human1.30323954
52AUTS2_25519132_ChIP-Seq_293T-REX_Human1.29104721
53MYC_19079543_ChIP-ChIP_MESCs_Mouse1.21466475
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20606162
55HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20512179
56GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19073665
57TAF15_26573619_Chip-Seq_HEK293_Human1.17980327
58NANOG_19829295_ChIP-Seq_ESCs_Human1.17950392
59SOX2_19829295_ChIP-Seq_ESCs_Human1.17950392
60GABP_19822575_ChIP-Seq_HepG2_Human1.15880834
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.15055563
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.14365946
63EZH2_22144423_ChIP-Seq_EOC_Human1.14158418
64AR_20517297_ChIP-Seq_VCAP_Human1.13590803
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13109778
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.13038591
67GATA3_21878914_ChIP-Seq_MCF-7_Human1.12653463
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12626246
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.11921853
70ER_23166858_ChIP-Seq_MCF-7_Human1.10932790
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.10925343
72ZFP57_27257070_Chip-Seq_ESCs_Mouse1.10557595
73HOXB7_26014856_ChIP-Seq_BT474_Human1.09078151
74SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07612512
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.04752745
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.02667171
77CBP_20019798_ChIP-Seq_JUKART_Human1.02667171
78NCOR_22424771_ChIP-Seq_293T_Human1.01885783
79DCP1A_22483619_ChIP-Seq_HELA_Human1.01301763
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01031631
81NANOG_16153702_ChIP-ChIP_HESCs_Human0.98933357
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98139344
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.96585404
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.95884316
85GATA3_26560356_Chip-Seq_TH2_Human0.95148373
86KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93858935
87NANOG_20526341_ChIP-Seq_ESCs_Human0.93611680
88GBX2_23144817_ChIP-Seq_PC3_Human0.93451681
89ETV2_25802403_ChIP-Seq_MESCs_Mouse0.93141282
90SALL1_21062744_ChIP-ChIP_HESCs_Human0.92208206
91BCAT_22108803_ChIP-Seq_LS180_Human0.90303624
92FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88816543
93FOXA1_21572438_ChIP-Seq_LNCaP_Human0.88783072
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.88452307
95EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87460318
96TDRD3_21172665_ChIP-Seq_MCF-7_Human0.86859576
97EGR1_23403033_ChIP-Seq_LIVER_Mouse0.86575281
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85041639
99MYC_19829295_ChIP-Seq_ESCs_Human0.84523065
100HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.83590270

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.62786801
2MP0006292_abnormal_olfactory_placode3.53800241
3MP0008058_abnormal_DNA_repair2.92742452
4MP0008875_abnormal_xenobiotic_pharmacok2.90899891
5MP0002138_abnormal_hepatobiliary_system2.86804334
6MP0005646_abnormal_pituitary_gland2.69256358
7MP0002102_abnormal_ear_morphology2.48812341
8MP0008872_abnormal_physiological_respon2.43513035
9MP0009379_abnormal_foot_pigmentation2.42911580
10MP0003693_abnormal_embryo_hatching2.41539030
11MP0003806_abnormal_nucleotide_metabolis2.21896001
12MP0003718_maternal_effect2.19520620
13MP0001835_abnormal_antigen_presentation2.04362562
14MP0010094_abnormal_chromosome_stability2.03114901
15MP0002736_abnormal_nociception_after2.00490083
16MP0001986_abnormal_taste_sensitivity1.87798188
17MP0001968_abnormal_touch/_nociception1.85294088
18MP0003787_abnormal_imprinting1.82268617
19MP0006072_abnormal_retinal_apoptosis1.81833871
20MP0003646_muscle_fatigue1.80606779
21MP0002837_dystrophic_cardiac_calcinosis1.75425046
22MP0003786_premature_aging1.75088067
23MP0001293_anophthalmia1.73739984
24MP0005645_abnormal_hypothalamus_physiol1.71777314
25MP0008007_abnormal_cellular_replicative1.70559459
26MP0004147_increased_porphyrin_level1.67979419
27MP0005671_abnormal_response_to1.60509469
28MP0005551_abnormal_eye_electrophysiolog1.58674924
29MP0008789_abnormal_olfactory_epithelium1.57425780
30MP0000372_irregular_coat_pigmentation1.56439418
31MP0005075_abnormal_melanosome_morpholog1.52650896
32MP0002938_white_spotting1.46291459
33MP0006036_abnormal_mitochondrial_physio1.45934220
34MP0002148_abnormal_hypersensitivity_rea1.41734938
35MP0004957_abnormal_blastocyst_morpholog1.35771850
36MP0002006_tumorigenesis1.34588899
37MP0001485_abnormal_pinna_reflex1.30595760
38MP0003011_delayed_dark_adaptation1.30419549
39MP0009764_decreased_sensitivity_to1.27873603
40MP0003111_abnormal_nucleus_morphology1.27700520
41MP0006035_abnormal_mitochondrial_morpho1.23018555
42MP0000685_abnormal_immune_system1.22653200
43MP0002254_reproductive_system_inflammat1.21716668
44MP0003195_calcinosis1.20030920
45MP0002272_abnormal_nervous_system1.17779430
46MP0000613_abnormal_salivary_gland1.17008243
47MP0004885_abnormal_endolymph1.11565947
48MP0003186_abnormal_redox_activity1.10659490
49MP0004133_heterotaxia1.09787018
50MP0001984_abnormal_olfaction1.08309832
51MP0005084_abnormal_gallbladder_morpholo1.07285851
52MP0003121_genomic_imprinting1.05735504
53MP0005085_abnormal_gallbladder_physiolo1.05254801
54MP0003136_yellow_coat_color1.04152833
55MP0002876_abnormal_thyroid_physiology1.01317895
56MP0001501_abnormal_sleep_pattern1.00287087
57MP0005377_hearing/vestibular/ear_phenot0.99886694
58MP0003878_abnormal_ear_physiology0.99886694
59MP0005332_abnormal_amino_acid0.98615801
60MP0004019_abnormal_vitamin_homeostasis0.94013042
61MP0001800_abnormal_humoral_immune0.93233734
62MP0005387_immune_system_phenotype0.91071928
63MP0001790_abnormal_immune_system0.91071928
64MP0005253_abnormal_eye_physiology0.90557013
65MP0008775_abnormal_heart_ventricle0.90003763
66MP0003567_abnormal_fetal_cardiomyocyte0.89703755
67MP0005636_abnormal_mineral_homeostasis0.89621731
68MP0009697_abnormal_copulation0.88512597
69MP0000427_abnormal_hair_cycle0.88350877
70MP0005389_reproductive_system_phenotype0.88212661
71MP0008932_abnormal_embryonic_tissue0.85735499
72MP0001929_abnormal_gametogenesis0.85555350
73MP0002210_abnormal_sex_determination0.85309059
74MP0000653_abnormal_sex_gland0.84080441
75MP0004145_abnormal_muscle_electrophysio0.83715177
76MP0002166_altered_tumor_susceptibility0.83297190
77MP0005499_abnormal_olfactory_system0.83147768
78MP0005394_taste/olfaction_phenotype0.83147768
79MP0005410_abnormal_fertilization0.82925536
80MP0002163_abnormal_gland_morphology0.82638420
81MP0002751_abnormal_autonomic_nervous0.82328534
82MP0001119_abnormal_female_reproductive0.79826448
83MP0002653_abnormal_ependyma_morphology0.77959479
84MP0005195_abnormal_posterior_eye0.77532719
85MP0001529_abnormal_vocalization0.77045008
86MP0001764_abnormal_homeostasis0.76398829
87MP0000516_abnormal_urinary_system0.76361279
88MP0005367_renal/urinary_system_phenotyp0.76361279
89MP0004142_abnormal_muscle_tone0.76149061
90MP0000631_abnormal_neuroendocrine_gland0.75540968
91MP0001145_abnormal_male_reproductive0.75475048
92MP0001663_abnormal_digestive_system0.74514822
93MP0004742_abnormal_vestibular_system0.74177459
94MP0002160_abnormal_reproductive_system0.74033214
95MP0000230_abnormal_systemic_arterial0.73742486
96MP0002277_abnormal_respiratory_mucosa0.73678648
97MP0001188_hyperpigmentation0.73312927
98MP0006276_abnormal_autonomic_nervous0.72455244
99MP0001486_abnormal_startle_reflex0.70956580
100MP0005379_endocrine/exocrine_gland_phen0.70731189

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.79771495
2Acute encephalopathy (HP:0006846)3.53399801
3Abolished electroretinogram (ERG) (HP:0000550)3.50379288
4Mitochondrial inheritance (HP:0001427)3.48321835
5Pancreatic cysts (HP:0001737)3.39201226
6Colon cancer (HP:0003003)3.36697176
7Increased CSF lactate (HP:0002490)3.36176709
8Increased hepatocellular lipid droplets (HP:0006565)3.28425875
9Progressive macrocephaly (HP:0004481)3.27408929
10Abnormal mitochondria in muscle tissue (HP:0008316)3.20421651
11Pancreatic fibrosis (HP:0100732)3.17544838
12Lipid accumulation in hepatocytes (HP:0006561)3.16235234
13Hepatocellular necrosis (HP:0001404)2.95127349
14Congenital stationary night blindness (HP:0007642)2.91723231
15Abnormality of the labia minora (HP:0012880)2.90160484
16Nephronophthisis (HP:0000090)2.86757257
17Cerebral edema (HP:0002181)2.77149469
18Congenital, generalized hypertrichosis (HP:0004540)2.74066170
19True hermaphroditism (HP:0010459)2.73244640
20Abnormality of midbrain morphology (HP:0002418)2.63779954
21Molar tooth sign on MRI (HP:0002419)2.63779954
22Abnormal biliary tract physiology (HP:0012439)2.61133003
23Bile duct proliferation (HP:0001408)2.61133003
24Hepatic necrosis (HP:0002605)2.59894038
25Type 2 muscle fiber atrophy (HP:0003554)2.59395923
263-Methylglutaconic aciduria (HP:0003535)2.59069210
27Increased serum lactate (HP:0002151)2.57410473
28Abnormality of the renal medulla (HP:0100957)2.50019121
29Septo-optic dysplasia (HP:0100842)2.49818026
30IgG deficiency (HP:0004315)2.47976793
31Pendular nystagmus (HP:0012043)2.46859974
32Abnormal rod and cone electroretinograms (HP:0008323)2.46644347
33Methylmalonic acidemia (HP:0002912)2.44456970
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.43382914
35Decreased electroretinogram (ERG) amplitude (HP:0000654)2.42834292
36Optic disc pallor (HP:0000543)2.42207504
37Absent rod-and cone-mediated responses on ERG (HP:0007688)2.40080797
38Reticulocytopenia (HP:0001896)2.35823512
39Prostate neoplasm (HP:0100787)2.33404888
40Lactic acidosis (HP:0003128)2.33157361
41Asplenia (HP:0001746)2.32063415
42Methylmalonic aciduria (HP:0012120)2.30073216
43Meckel diverticulum (HP:0002245)2.29681367
44Renal Fanconi syndrome (HP:0001994)2.29263676
45Dyschromatopsia (HP:0007641)2.29204674
46Stomatitis (HP:0010280)2.28423236
47Abnormality of the prostate (HP:0008775)2.24868011
48Lethargy (HP:0001254)2.24696983
49Increased intramyocellular lipid droplets (HP:0012240)2.24144932
50Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23919232
51Abnormality of cells of the erythroid lineage (HP:0012130)2.23747947
52Hyperglycinemia (HP:0002154)2.22669523
53Abnormality of the ileum (HP:0001549)2.20993835
54Exertional dyspnea (HP:0002875)2.20631284
55Neoplasm of the adrenal cortex (HP:0100641)2.13272866
56Chromsome breakage (HP:0040012)2.13034867
57Abnormality of the renal cortex (HP:0011035)2.12924025
58Type I transferrin isoform profile (HP:0003642)2.12482434
59Abnormality of B cell number (HP:0010975)2.12410524
60Type II lissencephaly (HP:0007260)2.11983658
61Hyperglycinuria (HP:0003108)2.11277725
62Abnormality of serine family amino acid metabolism (HP:0010894)2.10251786
63Abnormality of glycine metabolism (HP:0010895)2.10251786
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09892555
65Testicular atrophy (HP:0000029)2.09265085
66Abnormality of serum amino acid levels (HP:0003112)2.09024225
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.08481015
68Muscle fiber atrophy (HP:0100295)2.07237609
69Abnormality of alanine metabolism (HP:0010916)2.06848847
70Hyperalaninemia (HP:0003348)2.06848847
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.06848847
72Abnormal number of erythroid precursors (HP:0012131)2.06204986
73Abnormal drinking behavior (HP:0030082)2.05544590
74Polydipsia (HP:0001959)2.05544590
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.03791042
76Supernumerary spleens (HP:0009799)2.02332569
77Sclerocornea (HP:0000647)1.99593442
78Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98761984
79Abnormality of chromosome stability (HP:0003220)1.97413219
80Tubular atrophy (HP:0000092)1.96840975
81Hypomagnesemia (HP:0002917)1.96387109
82Hypoproteinemia (HP:0003075)1.96372290
83Neoplasm of the adrenal gland (HP:0100631)1.94436907
84Absent thumb (HP:0009777)1.92777970
85Cystic liver disease (HP:0006706)1.92690283
86Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91589932
87Elevated erythrocyte sedimentation rate (HP:0003565)1.90789838
88Pancytopenia (HP:0001876)1.89661437
89Increased muscle lipid content (HP:0009058)1.86758624
90Abnormality of the vitamin B12 metabolism (HP:0004341)1.83812948
91Abnormal spermatogenesis (HP:0008669)1.83548007
92Attenuation of retinal blood vessels (HP:0007843)1.83196008
93Stenosis of the external auditory canal (HP:0000402)1.82650449
94Clubbing of toes (HP:0100760)1.82605086
95B lymphocytopenia (HP:0010976)1.82439354
96Hypoplasia of the pons (HP:0012110)1.81451556
97Multiple enchondromatosis (HP:0005701)1.79594614
98Respiratory difficulties (HP:0002880)1.79371519
99Panhypogammaglobulinemia (HP:0003139)1.78902885
100Posterior subcapsular cataract (HP:0007787)1.78678115

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ZAK3.40488586
2NUAK13.39566434
3VRK22.94919304
4FRK2.71442836
5STK162.60880543
6EIF2AK32.50727155
7MAP4K22.39419913
8MST42.14530005
9TLK12.10149259
10MKNK22.02380582
11ADRBK21.99674985
12BUB11.99609425
13WNK31.99496890
14PLK31.99408760
15WNK41.98257008
16TAOK31.91192898
17TNIK1.88588572
18MKNK11.84298892
19EIF2AK11.80702646
20TSSK61.76307712
21CDK191.74861633
22BRSK21.72112847
23GRK11.70755707
24BMPR1B1.63134051
25OXSR11.62832506
26VRK11.61263440
27CDC71.59444793
28BCKDK1.54417695
29TAF11.51193450
30STK391.51111698
31PLK21.46026647
32TTK1.37635807
33TXK1.35499769
34PINK11.33783465
35SRPK11.31238725
36PBK1.25805364
37MAPKAPK31.24381614
38TIE11.23790943
39ACVR1B1.18413833
40TEC1.17782500
41EIF2AK21.14007847
42DYRK21.09843838
43PLK41.08741094
44BMPR21.03440625
45CSNK1G31.02004487
46TRIM281.01466750
47NEK11.00715638
48PLK10.97339732
49CSNK1G20.96855006
50MAPKAPK50.95806599
51CSNK1G10.89622439
52KIT0.88915815
53CSNK1A1L0.82738979
54PDK20.82522766
55DAPK10.81862659
56ATR0.81766137
57PHKG10.81479166
58PHKG20.81479166
59INSRR0.78471784
60MAP4K10.70375115
61ERBB30.64631149
62ALK0.63935265
63NME10.63792423
64EPHA40.63434736
65NME20.63372229
66PRKCQ0.61420367
67ITK0.61339069
68IKBKB0.61271390
69PIK3CA0.60654849
70STK38L0.59045675
71RPS6KA50.58124479
72WEE10.57246468
73MAP3K120.57217213
74CHEK20.56265439
75ADRBK10.53707683
76BRSK10.52787959
77FLT30.49037694
78TGFBR10.48941257
79PRKCG0.48234770
80GRK50.48025854
81ATM0.47508662
82SCYL20.46740374
83CSNK2A10.46053870
84AURKB0.45790125
85MAPK130.43933522
86PRKCI0.43752832
87CSNK2A20.41824656
88CSNK1A10.41642845
89SYK0.41623909
90WNK10.36724004
91PRKCA0.35239506
92DAPK20.34642730
93LYN0.33608804
94PRKDC0.30704844
95BTK0.30168133
96KDR0.27683251
97STK30.27316160
98FGFR20.26888320
99CSNK1E0.26673079
100DAPK30.26377756

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.88005847
2Asthma_Homo sapiens_hsa053103.74517609
3Allograft rejection_Homo sapiens_hsa053302.71150282
4Intestinal immune network for IgA production_Homo sapiens_hsa046722.68463487
5Ribosome_Homo sapiens_hsa030102.57232298
6Autoimmune thyroid disease_Homo sapiens_hsa053202.55818295
7RNA polymerase_Homo sapiens_hsa030202.49824957
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.20465624
9Oxidative phosphorylation_Homo sapiens_hsa001902.18317870
10Type I diabetes mellitus_Homo sapiens_hsa049402.14116531
11Graft-versus-host disease_Homo sapiens_hsa053322.13441587
12Mismatch repair_Homo sapiens_hsa034302.03741222
13Homologous recombination_Homo sapiens_hsa034402.02109863
14Protein export_Homo sapiens_hsa030601.99415451
15Caffeine metabolism_Homo sapiens_hsa002321.93488313
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.91716580
17Parkinsons disease_Homo sapiens_hsa050121.88385704
18Non-homologous end-joining_Homo sapiens_hsa034501.86357634
19One carbon pool by folate_Homo sapiens_hsa006701.81484784
20Linoleic acid metabolism_Homo sapiens_hsa005911.74295831
21RNA degradation_Homo sapiens_hsa030181.72308282
22Propanoate metabolism_Homo sapiens_hsa006401.67485578
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.59655526
24DNA replication_Homo sapiens_hsa030301.53571158
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.47335978
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44095120
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43084257
28Basal transcription factors_Homo sapiens_hsa030221.42345646
29Fanconi anemia pathway_Homo sapiens_hsa034601.40926320
30Phototransduction_Homo sapiens_hsa047441.38630690
31RNA transport_Homo sapiens_hsa030131.27889938
32Nucleotide excision repair_Homo sapiens_hsa034201.26293344
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25525844
34Nitrogen metabolism_Homo sapiens_hsa009101.24604981
35Antigen processing and presentation_Homo sapiens_hsa046121.24526465
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24260618
37Pyrimidine metabolism_Homo sapiens_hsa002401.24214027
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20596159
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.19342746
40Base excision repair_Homo sapiens_hsa034101.18370939
41Huntingtons disease_Homo sapiens_hsa050161.16803575
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.08646352
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07412106
44Ether lipid metabolism_Homo sapiens_hsa005651.05496331
45Tryptophan metabolism_Homo sapiens_hsa003801.05413521
46Purine metabolism_Homo sapiens_hsa002301.03206809
47Alzheimers disease_Homo sapiens_hsa050101.01766126
48Selenocompound metabolism_Homo sapiens_hsa004501.00991562
49Fat digestion and absorption_Homo sapiens_hsa049750.99782977
50Primary immunodeficiency_Homo sapiens_hsa053400.99302741
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96533092
52Arachidonic acid metabolism_Homo sapiens_hsa005900.96474078
53Spliceosome_Homo sapiens_hsa030400.94021140
54Rheumatoid arthritis_Homo sapiens_hsa053230.91018368
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89298629
56Chemical carcinogenesis_Homo sapiens_hsa052040.88635237
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84943243
58Cyanoamino acid metabolism_Homo sapiens_hsa004600.83373009
59Peroxisome_Homo sapiens_hsa041460.81400016
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.79636729
61Viral myocarditis_Homo sapiens_hsa054160.78186860
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.75971495
63Cardiac muscle contraction_Homo sapiens_hsa042600.75024547
64Staphylococcus aureus infection_Homo sapiens_hsa051500.73774621
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70824545
66Butanoate metabolism_Homo sapiens_hsa006500.70688566
67Retinol metabolism_Homo sapiens_hsa008300.69809426
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67619943
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63516516
70Steroid biosynthesis_Homo sapiens_hsa001000.63457154
71Pyruvate metabolism_Homo sapiens_hsa006200.63074384
72Systemic lupus erythematosus_Homo sapiens_hsa053220.62761195
73Metabolic pathways_Homo sapiens_hsa011000.62461576
74Glutathione metabolism_Homo sapiens_hsa004800.62212151
75Fatty acid degradation_Homo sapiens_hsa000710.61649882
76Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61343284
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60179731
78Vitamin digestion and absorption_Homo sapiens_hsa049770.58440857
79Regulation of autophagy_Homo sapiens_hsa041400.58019863
80Hematopoietic cell lineage_Homo sapiens_hsa046400.54326576
81Vitamin B6 metabolism_Homo sapiens_hsa007500.50670423
82Fatty acid elongation_Homo sapiens_hsa000620.49985119
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48187884
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47950856
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.46802565
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46666369
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45289739
88Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45121309
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.44479717
90Sulfur metabolism_Homo sapiens_hsa009200.43589352
91Olfactory transduction_Homo sapiens_hsa047400.42896519
92Sulfur relay system_Homo sapiens_hsa041220.41185731
93Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39661812
94beta-Alanine metabolism_Homo sapiens_hsa004100.37513732
95Epstein-Barr virus infection_Homo sapiens_hsa051690.35084168
96Glycerolipid metabolism_Homo sapiens_hsa005610.29026277
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27640092
98Mineral absorption_Homo sapiens_hsa049780.24757437
99Cell cycle_Homo sapiens_hsa041100.23712334
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.23084212

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