ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cell wall macromolecule catabolic process (GO:0016998)	5.92720024
2	phenol-containing compound catabolic process (GO:0019336)	5.15707319
3	cell wall macromolecule metabolic process (GO:0044036)	4.94418473
4	sulfation (GO:0051923)	4.85284237
5	protein-cofactor linkage (GO:0018065)	4.79179720
6	thyroid hormone generation (GO:0006590)	4.30258291
7	somite development (GO:0061053)	4.28574637
8	thyroid hormone metabolic process (GO:0042403)	4.09615557
9	interferon-gamma production (GO:0032609)	3.89925421
10	regulation of hexokinase activity (GO:1903299)	3.83059333
11	regulation of glucokinase activity (GO:0033131)	3.83059333
12	adaptation of signaling pathway (GO:0023058)	3.81342727
13	epithelial cilium movement (GO:0003351)	3.77633690
14	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.68075556
15	behavioral response to nicotine (GO:0035095)	3.53247076
16	preassembly of GPI anchor in ER membrane (GO:0016254)	3.53217459
17	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	3.52520750
18	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	3.52520750
19	hormone catabolic process (GO:0042447)	3.50833204
20	rhodopsin mediated signaling pathway (GO:0016056)	3.50794311
21	piRNA metabolic process (GO:0034587)	3.46149142
22	indolalkylamine metabolic process (GO:0006586)	3.35464136
23	tryptophan metabolic process (GO:0006568)	3.25846722
24	regulation of meiosis I (GO:0060631)	3.25767536
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.23099556
26	NADH dehydrogenase complex assembly (GO:0010257)	3.23099556
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.23099556
28	negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)	3.18965971
29	estrogen metabolic process (GO:0008210)	3.18790463
30	indole-containing compound catabolic process (GO:0042436)	3.11514494
31	indolalkylamine catabolic process (GO:0046218)	3.11514494
32	tryptophan catabolic process (GO:0006569)	3.11514494
33	protein localization to cilium (GO:0061512)	3.11402211
34	ventricular system development (GO:0021591)	3.08766524
35	branched-chain amino acid catabolic process (GO:0009083)	3.06223996
36	DNA deamination (GO:0045006)	3.05868116
37	prostate gland growth (GO:0060736)	3.04534456
38	photoreceptor cell maintenance (GO:0045494)	3.03132154
39	ubiquinone biosynthetic process (GO:0006744)	3.01565770
40	protein complex biogenesis (GO:0070271)	2.97853280
41	negative regulation of multicellular organism growth (GO:0040015)	2.97454444
42	male meiosis (GO:0007140)	2.96654022
43	GPI anchor metabolic process (GO:0006505)	2.95118626
44	mitochondrial respiratory chain complex assembly (GO:0033108)	2.94348586
45	axoneme assembly (GO:0035082)	2.92567968
46	nonmotile primary cilium assembly (GO:0035058)	2.88243238
47	head development (GO:0060322)	2.86382087
48	intraciliary transport (GO:0042073)	2.84701399
49	synaptic transmission, cholinergic (GO:0007271)	2.84203355
50	regulation of mesoderm development (GO:2000380)	2.82962308
51	kidney morphogenesis (GO:0060993)	2.82886272
52	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.82411226
53	cilium movement (GO:0003341)	2.81295946
54	synapsis (GO:0007129)	2.80754544
55	DNA integration (GO:0015074)	2.79011077
56	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.78822524
57	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.78822524
58	isotype switching (GO:0045190)	2.78822524
59	ubiquinone metabolic process (GO:0006743)	2.77336407
60	regulation of mitochondrial translation (GO:0070129)	2.75291652
61	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.75006168
62	regulation of respiratory system process (GO:0044065)	2.74542525
63	protein ADP-ribosylation (GO:0006471)	2.74404912
64	branched-chain amino acid metabolic process (GO:0009081)	2.71372264
65	protein K11-linked deubiquitination (GO:0035871)	2.71124894
66	negative regulation of mast cell activation (GO:0033004)	2.70329651
67	C-terminal protein amino acid modification (GO:0018410)	2.70134409
68	platelet dense granule organization (GO:0060155)	2.63664904
69	replicative senescence (GO:0090399)	2.63611213
70	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63342121
71	protein polyglutamylation (GO:0018095)	2.62563336
72	neural tube formation (GO:0001841)	2.60471682
73	cilium morphogenesis (GO:0060271)	2.59828088
74	ADP metabolic process (GO:0046031)	2.59290407
75	adenosine metabolic process (GO:0046085)	2.53193680
76	C-terminal protein lipidation (GO:0006501)	2.52838925
77	neuron fate determination (GO:0048664)	2.52001415
78	aggressive behavior (GO:0002118)	2.51960618
79	rRNA catabolic process (GO:0016075)	2.49313342
80	DNA double-strand break processing (GO:0000729)	2.48721300
81	positive regulation of cell cycle G1/S phase transition (GO:1902808)	2.48576211
82	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.47738999
83	positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)	2.47511620
84	cAMP catabolic process (GO:0006198)	2.46152333
85	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.45975326
86	DNA catabolic process, exonucleolytic (GO:0000738)	2.45783010
87	limb bud formation (GO:0060174)	2.45005278
88	quinone biosynthetic process (GO:1901663)	2.42971198
89	negative regulation of systemic arterial blood pressure (GO:0003085)	2.42767900
90	indole-containing compound metabolic process (GO:0042430)	2.42419440
91	synaptonemal complex assembly (GO:0007130)	2.41795870
92	activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)	2.41579079
93	male meiosis I (GO:0007141)	2.40871029
94	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.40237515
95	termination of RNA polymerase III transcription (GO:0006386)	2.39022188
96	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.39022188
97	L-fucose catabolic process (GO:0042355)	2.37720575
98	fucose catabolic process (GO:0019317)	2.37720575
99	L-fucose metabolic process (GO:0042354)	2.37720575
100	fatty acid elongation (GO:0030497)	2.37538079

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	4.42466738
2	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.15614190
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.23846966
4	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.80033554
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.61995227
6	VDR_22108803_ChIP-Seq_LS180_Human	2.61580754
7	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.56490240
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.56178507
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.52029379
10	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.42642324
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.42259178
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.40602637
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.32624234
14	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.14491844
15	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.13992228
16	EWS_26573619_Chip-Seq_HEK293_Human	2.03396452
17	FUS_26573619_Chip-Seq_HEK293_Human	2.01349870
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.97436483
19	P300_19829295_ChIP-Seq_ESCs_Human	1.89112090
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.76899612
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.76139649
22	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.75721808
23	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.74440683
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.64472208
25	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.62629437
26	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60536826
27	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.60449298
28	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.59709834
29	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.55470129
30	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53642789
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.50934719
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.50934719
33	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.48670983
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.47568893
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.47459219
36	EZH2_22144423_ChIP-Seq_EOC_Human	1.47356696
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.45245325
38	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.43786556
39	SMAD4_21799915_ChIP-Seq_A2780_Human	1.43535898
40	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.40475427
41	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.39781752
42	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.39726336
43	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.39610555
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.39068682
45	AR_25329375_ChIP-Seq_VCAP_Human	1.37714093
46	STAT3_23295773_ChIP-Seq_U87_Human	1.36220056
47	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.36142379
48	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35196412
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35087296
50	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35087296
51	RNF2_27304074_Chip-Seq_NSC_Mouse	1.33503413
52	VDR_23849224_ChIP-Seq_CD4+_Human	1.32307099
53	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.32301184
54	TP53_22573176_ChIP-Seq_HFKS_Human	1.29726705
55	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28541649
56	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.28541649
57	TCF4_23295773_ChIP-Seq_U87_Human	1.28416787
58	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.27798984
59	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25666049
60	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24473637
61	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.23858576
62	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.23735031
63	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22975642
64	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.21977524
65	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.20267154
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.20012754
67	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.19219624
68	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19215144
69	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19215144
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.18614340
71	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.17276652
72	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.17009088
73	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.15596575
74	ELK1_19687146_ChIP-ChIP_HELA_Human	1.15477815
75	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14356862
76	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13853487
77	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13412297
78	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.13133949
79	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.12819304
80	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12094280
81	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11275842
82	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10782612
83	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10736799
84	TCF4_22108803_ChIP-Seq_LS180_Human	1.10706843
85	P53_22387025_ChIP-Seq_ESCs_Mouse	1.10503752
86	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.10289897
87	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.09365645
88	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.08723018
89	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.08512851
90	BCAT_22108803_ChIP-Seq_LS180_Human	1.07187952
91	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.06287102
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.05510265
93	AR_20517297_ChIP-Seq_VCAP_Human	1.04558245
94	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.03873221
95	IRF1_19129219_ChIP-ChIP_H3396_Human	1.03503630
96	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.03459249
97	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02243108
98	P300_18555785_Chip-Seq_ESCs_Mouse	1.01154057
99	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00333929
100	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00049151

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	3.26508098
2	MP0005645_abnormal_hypothalamus_physiol	3.23911805
3	MP0008877_abnormal_DNA_methylation	2.86075804
4	MP0001968_abnormal_touch/_nociception	2.80964729
5	MP0005646_abnormal_pituitary_gland	2.75049014
6	MP0002736_abnormal_nociception_after	2.54404360
7	MP0002837_dystrophic_cardiac_calcinosis	2.48351948
8	MP0006072_abnormal_retinal_apoptosis	2.44344108
9	MP0008058_abnormal_DNA_repair	2.35185129
10	MP0008057_abnormal_DNA_replication	2.33298110
11	MP0002876_abnormal_thyroid_physiology	2.31648029
12	MP0002009_preneoplasia	2.24287062
13	MP0002102_abnormal_ear_morphology	2.22906300
14	MP0000569_abnormal_digit_pigmentation	2.11716593
15	MP0004142_abnormal_muscle_tone	1.93166547
16	MP0002638_abnormal_pupillary_reflex	1.91759620
17	MP0000383_abnormal_hair_follicle	1.91519569
18	MP0001984_abnormal_olfaction	1.89855814
19	MP0003567_abnormal_fetal_cardiomyocyte	1.78476805
20	MP0005253_abnormal_eye_physiology	1.71747050
21	MP0004885_abnormal_endolymph	1.66796504
22	MP0005551_abnormal_eye_electrophysiolog	1.60041868
23	MP0001764_abnormal_homeostasis	1.58714102
24	MP0001986_abnormal_taste_sensitivity	1.56565286
25	MP0009053_abnormal_anal_canal	1.56497098
26	MP0003646_muscle_fatigue	1.52763743
27	MP0002254_reproductive_system_inflammat	1.51795211
28	MP0000613_abnormal_salivary_gland	1.51208325
29	MP0002653_abnormal_ependyma_morphology	1.51126772
30	MP0005084_abnormal_gallbladder_morpholo	1.49917694
31	MP0008872_abnormal_physiological_respon	1.48450083
32	MP0009046_muscle_twitch	1.47926578
33	MP0001529_abnormal_vocalization	1.43578542
34	MP0006276_abnormal_autonomic_nervous	1.42975830
35	MP0002272_abnormal_nervous_system	1.38576974
36	MP0000372_irregular_coat_pigmentation	1.36298678
37	MP0001905_abnormal_dopamine_level	1.28964591
38	MP0009250_abnormal_appendicular_skeleto	1.26944580
39	MP0004134_abnormal_chest_morphology	1.26850845
40	MP0008995_early_reproductive_senescence	1.25752996
41	MP0003786_premature_aging	1.22993045
42	MP0001299_abnormal_eye_distance/	1.20332571
43	MP0000631_abnormal_neuroendocrine_gland	1.19043400
44	MP0003787_abnormal_imprinting	1.18489257
45	MP0000516_abnormal_urinary_system	1.18057097
46	MP0005367_renal/urinary_system_phenotyp	1.18057097
47	MP0008775_abnormal_heart_ventricle	1.16722213
48	MP0006292_abnormal_olfactory_placode	1.15700695
49	MP0003252_abnormal_bile_duct	1.11783053
50	MP0002751_abnormal_autonomic_nervous	1.10639214
51	MP0006036_abnormal_mitochondrial_physio	1.10164263
52	MP0000049_abnormal_middle_ear	1.08787956
53	MP0005671_abnormal_response_to	1.08465466
54	MP0001486_abnormal_startle_reflex	1.06502081
55	MP0005410_abnormal_fertilization	1.05622846
56	MP0001502_abnormal_circadian_rhythm	1.03815757
57	MP0004145_abnormal_muscle_electrophysio	1.03377481
58	MP0000685_abnormal_immune_system	1.02765886
59	MP0002928_abnormal_bile_duct	1.01942476
60	MP0009745_abnormal_behavioral_response	1.00842083
61	MP0000749_muscle_degeneration	0.99978086
62	MP0002733_abnormal_thermal_nociception	0.99840206
63	MP0001346_abnormal_lacrimal_gland	0.98868478
64	MP0002138_abnormal_hepatobiliary_system	0.98180264
65	MP0002282_abnormal_trachea_morphology	0.96656850
66	MP0005503_abnormal_tendon_morphology	0.92757508
67	MP0003880_abnormal_central_pattern	0.91420920
68	MP0000653_abnormal_sex_gland	0.90179265
69	MP0002067_abnormal_sensory_capabilities	0.89898862
70	MP0001293_anophthalmia	0.89253116
71	MP0003656_abnormal_erythrocyte_physiolo	0.88639269
72	MP0002127_abnormal_cardiovascular_syste	0.88596668
73	MP0010678_abnormal_skin_adnexa	0.88164780
74	MP0000427_abnormal_hair_cycle	0.87946456
75	MP0001145_abnormal_male_reproductive	0.86411627
76	MP0005389_reproductive_system_phenotype	0.86361223
77	MP0003937_abnormal_limbs/digits/tail_de	0.84846692
78	MP0001970_abnormal_pain_threshold	0.84226916
79	MP0003119_abnormal_digestive_system	0.83009983
80	MP0010386_abnormal_urinary_bladder	0.82837987
81	MP0005266_abnormal_metabolism	0.82256114
82	MP0002166_altered_tumor_susceptibility	0.81432267
83	MP0002109_abnormal_limb_morphology	0.79424781
84	MP0008789_abnormal_olfactory_epithelium	0.78366561
85	MP0002210_abnormal_sex_determination	0.78114335
86	MP0003868_abnormal_feces_composition	0.77207112
87	MP0002160_abnormal_reproductive_system	0.76829814
88	MP0001542_abnormal_bone_strength	0.76739762
89	MP0005075_abnormal_melanosome_morpholog	0.76134408
90	MP0004147_increased_porphyrin_level	0.75651766
91	MP0003183_abnormal_peptide_metabolism	0.74942958
92	MP0001963_abnormal_hearing_physiology	0.74592636
93	MP0003763_abnormal_thymus_physiology	0.74539058
94	MP0003698_abnormal_male_reproductive	0.73489323
95	MP0000013_abnormal_adipose_tissue	0.72170441
96	MP0002332_abnormal_exercise_endurance	0.71614432
97	MP0002735_abnormal_chemical_nociception	0.70907784
98	MP0001929_abnormal_gametogenesis	0.69661772
99	MP0000026_abnormal_inner_ear	0.68033730
100	MP0002734_abnormal_mechanical_nocicepti	0.67407263

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe combined immunodeficiency (HP:0004430)	3.83912430
2	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.80422361
3	Short tibia (HP:0005736)	3.79516867
4	Abnormality of midbrain morphology (HP:0002418)	3.77568432
5	Molar tooth sign on MRI (HP:0002419)	3.77568432
6	Pancreatic cysts (HP:0001737)	3.69509234
7	Thyroiditis (HP:0100646)	3.55719278
8	Pancreatic fibrosis (HP:0100732)	3.47608472
9	True hermaphroditism (HP:0010459)	3.20410162
10	Renal cortical cysts (HP:0000803)	3.17104898
11	Concave nail (HP:0001598)	3.10320003
12	Increased corneal curvature (HP:0100692)	3.07706192
13	Keratoconus (HP:0000563)	3.07706192
14	Abnormality of the phalanges of the 2nd finger (HP:0009541)	3.07300962
15	Hypoproteinemia (HP:0003075)	2.97696486
16	Genital tract atresia (HP:0001827)	2.96937077
17	Medial flaring of the eyebrow (HP:0010747)	2.95095539
18	Bifid tongue (HP:0010297)	2.93750171
19	Abnormality of the renal cortex (HP:0011035)	2.88863243
20	Combined immunodeficiency (HP:0005387)	2.88820605
21	Congenital primary aphakia (HP:0007707)	2.86946483
22	Nephrogenic diabetes insipidus (HP:0009806)	2.84978462
23	Nephronophthisis (HP:0000090)	2.81163468
24	Gait imbalance (HP:0002141)	2.78643758
25	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.66403552
26	Hyperventilation (HP:0002883)	2.65558242
27	Vaginal atresia (HP:0000148)	2.64616504
28	Abnormality of B cell number (HP:0010975)	2.60816144
29	Acute necrotizing encephalopathy (HP:0006965)	2.52431182
30	Symphalangism affecting the phalanges of the hand (HP:0009773)	2.49611167
31	Congenital stationary night blindness (HP:0007642)	2.49102182
32	Intestinal atresia (HP:0011100)	2.44655893
33	Abnormality of the renal medulla (HP:0100957)	2.39118728
34	Focal motor seizures (HP:0011153)	2.35386315
35	Methylmalonic acidemia (HP:0002912)	2.35016180
36	Abnormal finger flexion creases (HP:0006143)	2.34971321
37	B lymphocytopenia (HP:0010976)	2.32615013
38	Progressive macrocephaly (HP:0004481)	2.29974919
39	Abnormality of the 4th metacarpal (HP:0010012)	2.28509748
40	Acute encephalopathy (HP:0006846)	2.27660951
41	Metaphyseal dysplasia (HP:0100255)	2.21918060
42	Abnormal mitochondria in muscle tissue (HP:0008316)	2.21151983
43	Abnormality of the renal collecting system (HP:0004742)	2.20007124
44	Mitochondrial inheritance (HP:0001427)	2.19782277
45	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	2.18771447
46	Stomach cancer (HP:0012126)	2.18042310
47	Pigmentary retinal degeneration (HP:0001146)	2.14664519
48	Abnormality of the pubic bones (HP:0003172)	2.14284238
49	Large for gestational age (HP:0001520)	2.14066894
50	Colon cancer (HP:0003003)	2.07150530
51	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.06535785
52	Abnormality of the phalanges of the 5th finger (HP:0004213)	2.06483763
53	Aplasia/Hypoplasia of the lens (HP:0008063)	2.05796486
54	IgG deficiency (HP:0004315)	2.05023721
55	Duplicated collecting system (HP:0000081)	2.02995487
56	Absent phalangeal crease (HP:0006109)	2.02581141
57	Hypoalbuminemia (HP:0003073)	2.01427992
58	Abnormal albumin level (HP:0012116)	2.01427992
59	Cystic liver disease (HP:0006706)	2.01268507
60	11 pairs of ribs (HP:0000878)	1.98171632
61	Abnormal rod and cone electroretinograms (HP:0008323)	1.97572379
62	Postaxial foot polydactyly (HP:0001830)	1.96439096
63	Ependymoma (HP:0002888)	1.94810487
64	Anencephaly (HP:0002323)	1.94561332
65	Fibular hypoplasia (HP:0003038)	1.92709150
66	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.92581380
67	Small hand (HP:0200055)	1.90085630
68	Vitreoretinal degeneration (HP:0000655)	1.87872537
69	Morphological abnormality of the middle ear (HP:0008609)	1.87871231
70	Postaxial hand polydactyly (HP:0001162)	1.87557362
71	Erythroderma (HP:0001019)	1.86830727
72	Methylmalonic aciduria (HP:0012120)	1.86783855
73	Increased number of teeth (HP:0011069)	1.86748912
74	Abolished electroretinogram (ERG) (HP:0000550)	1.85760247
75	Adactyly (HP:0009776)	1.85256163
76	Hyperglycinemia (HP:0002154)	1.84744725
77	Abnormality of T cell physiology (HP:0011840)	1.84409174
78	Chronic hepatic failure (HP:0100626)	1.84038987
79	Long nose (HP:0003189)	1.83231104
80	Congenital hepatic fibrosis (HP:0002612)	1.81188326
81	Increased CSF lactate (HP:0002490)	1.80681042
82	Hypoplasia of the thymus (HP:0000778)	1.79557749
83	Congenital, generalized hypertrichosis (HP:0004540)	1.78716021
84	Cerebral edema (HP:0002181)	1.78283518
85	Glioma (HP:0009733)	1.77268849
86	Synostosis involving the elbow (HP:0003938)	1.75079491
87	Humeroradial synostosis (HP:0003041)	1.75079491
88	Volvulus (HP:0002580)	1.74565125
89	Retinal dysplasia (HP:0007973)	1.74517332
90	Neonatal respiratory distress (HP:0002643)	1.72780550
91	Hypoplastic iliac wings (HP:0002866)	1.72195185
92	Broad foot (HP:0001769)	1.72075895
93	Abnormal respiratory motile cilium physiology (HP:0012261)	1.71520841
94	Poor coordination (HP:0002370)	1.71303726
95	Rhinitis (HP:0012384)	1.68811572
96	Limb hypertonia (HP:0002509)	1.68564696
97	Autoimmune thrombocytopenia (HP:0001973)	1.68467287
98	Pendular nystagmus (HP:0012043)	1.68417917
99	Agammaglobulinemia (HP:0004432)	1.67988743
100	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.67774716

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	6.28333718
2	FRK	4.09130821
3	NUAK1	3.09979301
4	GRK7	2.66733527
5	MAPK13	2.58556533
6	ZAK	2.40212492
7	ADRBK2	2.09307410
8	WNK3	2.06239161
9	MAP3K4	1.73779187
10	CAMKK2	1.68004061
11	TAOK3	1.66555881
12	FGFR2	1.61138099
13	TGFBR2	1.51828165
14	GRK1	1.47670970
15	INSRR	1.46535154
16	RPS6KA4	1.37247669
17	MAP4K2	1.36574167
18	OXSR1	1.32994905
19	IRAK2	1.30448626
20	ITK	1.23467793
21	BCKDK	1.22285898
22	ACVR1B	1.17969970
23	GRK5	1.16107247
24	PIK3CA	1.14595663
25	VRK2	1.14213302
26	EIF2AK1	1.11106188
27	OBSCN	1.07904833
28	DYRK3	1.07264026
29	BRSK2	1.05409119
30	KDR	1.04629617
31	MOS	1.03822631
32	CAMK4	1.02397972
33	PBK	1.01486224
34	TEC	0.99635685
35	MAPKAPK3	0.96976390
36	PAK3	0.96292536
37	STK38L	0.96222106
38	NME1	0.95584768
39	KIT	0.93473602
40	PINK1	0.89524589
41	STK10	0.88514652
42	ADRBK1	0.79955400
43	CDK3	0.79952977
44	PHKG2	0.78616988
45	PHKG1	0.78616988
46	FLT3	0.77970182
47	STK39	0.76665830
48	PRKCE	0.75820813
49	DAPK1	0.74491991
50	PKN1	0.72629560
51	MAP4K1	0.69652210
52	STK16	0.69333420
53	CASK	0.68305251
54	MAP3K2	0.67077631
55	DAPK2	0.66723796
56	VRK1	0.65113564
57	UHMK1	0.64213446
58	CAMKK1	0.63776297
59	PLK2	0.62900084
60	IGF1R	0.58708490
61	NTRK3	0.57813180
62	STK11	0.57556144
63	CAMK1	0.57094289
64	EIF2AK2	0.56529965
65	BCR	0.53936085
66	MAP2K7	0.52822737
67	MAP2K6	0.52818885
68	MAP3K7	0.52131038
69	TLK1	0.51748485
70	AKT3	0.50674491
71	CAMK2A	0.50546009
72	CAMK2B	0.49887924
73	MST4	0.48879083
74	SYK	0.48861377
75	ERBB3	0.48751273
76	PDK1	0.48665094
77	GRK6	0.48466055
78	MKNK1	0.48145938
79	PRKACA	0.46801964
80	PLK4	0.46525510
81	SGK2	0.46213232
82	MKNK2	0.45926087
83	ERBB2	0.45462634
84	EIF2AK3	0.43868819
85	SRPK1	0.43697221
86	RPS6KA6	0.43378254
87	CSNK1G3	0.43270205
88	PRKG1	0.43249840
89	MAPK11	0.42617089
90	RPS6KA5	0.42088619
91	PRKCG	0.41715277
92	CSNK1A1	0.41661800
93	EPHA3	0.39835433
94	ATR	0.38792477
95	CSNK1G1	0.38683222
96	IKBKB	0.37861154
97	JAK2	0.37085120
98	PIM1	0.36071673
99	HIPK2	0.35697886
100	CAMK2D	0.35464422

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.46871308
2	Phototransduction_Homo sapiens_hsa04744	2.86384481
3	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.29227804
4	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.23606357
5	Primary immunodeficiency_Homo sapiens_hsa05340	2.21923759
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.21600689
7	RNA polymerase_Homo sapiens_hsa03020	2.11357126
8	Propanoate metabolism_Homo sapiens_hsa00640	2.01793083
9	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.87695298
10	Caffeine metabolism_Homo sapiens_hsa00232	1.81537998
11	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80092917
12	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.78428809
13	Linoleic acid metabolism_Homo sapiens_hsa00591	1.75823428
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.65925143
15	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.65123662
16	Butanoate metabolism_Homo sapiens_hsa00650	1.65076069
17	Parkinsons disease_Homo sapiens_hsa05012	1.61438118
18	Protein export_Homo sapiens_hsa03060	1.58577184
19	Nicotine addiction_Homo sapiens_hsa05033	1.58321333
20	Circadian rhythm_Homo sapiens_hsa04710	1.52766417
21	Proteasome_Homo sapiens_hsa03050	1.49722584
22	Nitrogen metabolism_Homo sapiens_hsa00910	1.48556613
23	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.48476825
24	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.44957535
25	Homologous recombination_Homo sapiens_hsa03440	1.42600731
26	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.41405674
27	Olfactory transduction_Homo sapiens_hsa04740	1.40619966
28	Selenocompound metabolism_Homo sapiens_hsa00450	1.40090760
29	Purine metabolism_Homo sapiens_hsa00230	1.37851458
30	RNA degradation_Homo sapiens_hsa03018	1.36720605
31	Taste transduction_Homo sapiens_hsa04742	1.35764751
32	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.34781074
33	Non-homologous end-joining_Homo sapiens_hsa03450	1.33029804
34	Peroxisome_Homo sapiens_hsa04146	1.29558961
35	Sulfur metabolism_Homo sapiens_hsa00920	1.27914160
36	Renin secretion_Homo sapiens_hsa04924	1.26898667
37	Fatty acid elongation_Homo sapiens_hsa00062	1.26885347
38	Tryptophan metabolism_Homo sapiens_hsa00380	1.25004018
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22978412
40	Circadian entrainment_Homo sapiens_hsa04713	1.21453375
41	ABC transporters_Homo sapiens_hsa02010	1.19358587
42	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.17848350
43	Ether lipid metabolism_Homo sapiens_hsa00565	1.15330030
44	Sulfur relay system_Homo sapiens_hsa04122	1.15029864
45	Pyrimidine metabolism_Homo sapiens_hsa00240	1.12730899
46	Salivary secretion_Homo sapiens_hsa04970	1.04385788
47	Basal transcription factors_Homo sapiens_hsa03022	1.04107631
48	Huntingtons disease_Homo sapiens_hsa05016	1.01581355
49	Alzheimers disease_Homo sapiens_hsa05010	0.99304495
50	Morphine addiction_Homo sapiens_hsa05032	0.98678129
51	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.95588082
52	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.93449548
53	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.90271969
54	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.84596861
55	Regulation of autophagy_Homo sapiens_hsa04140	0.83448884
56	Chemical carcinogenesis_Homo sapiens_hsa05204	0.80784545
57	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.78563663
58	Amphetamine addiction_Homo sapiens_hsa05031	0.76003802
59	Nucleotide excision repair_Homo sapiens_hsa03420	0.75561810
60	Collecting duct acid secretion_Homo sapiens_hsa04966	0.74747213
61	Antigen processing and presentation_Homo sapiens_hsa04612	0.74674105
62	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.72545367
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.70691383
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69445180
65	GABAergic synapse_Homo sapiens_hsa04727	0.67443017
66	Serotonergic synapse_Homo sapiens_hsa04726	0.64862875
67	Rheumatoid arthritis_Homo sapiens_hsa05323	0.64658360
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63638213
69	Allograft rejection_Homo sapiens_hsa05330	0.62981670
70	Graft-versus-host disease_Homo sapiens_hsa05332	0.60666691
71	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59660183
72	Cardiac muscle contraction_Homo sapiens_hsa04260	0.59538299
73	Asthma_Homo sapiens_hsa05310	0.59304868
74	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.57688046
75	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.57669977
76	Base excision repair_Homo sapiens_hsa03410	0.55994366
77	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.55858763
78	Retinol metabolism_Homo sapiens_hsa00830	0.55503260
79	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.54339388
80	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.51705948
81	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.51330690
82	Long-term depression_Homo sapiens_hsa04730	0.51253007
83	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.50911398
84	Calcium signaling pathway_Homo sapiens_hsa04020	0.50484220
85	Metabolic pathways_Homo sapiens_hsa01100	0.50425494
86	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49133677
87	Cocaine addiction_Homo sapiens_hsa05030	0.47538945
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.46820249
89	Mismatch repair_Homo sapiens_hsa03430	0.46135331
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.45870864
91	cAMP signaling pathway_Homo sapiens_hsa04024	0.44994902
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44378759
93	Dopaminergic synapse_Homo sapiens_hsa04728	0.43283534
94	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.38578051
95	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.37268198
96	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.36788940
97	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.36416730
98	Oocyte meiosis_Homo sapiens_hsa04114	0.36367673
99	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.35696161
100	Melanoma_Homo sapiens_hsa05218	0.34778587

RPL7P21

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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