ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.74590506
2	ribosomal small subunit assembly (GO:0000028)	5.56969432
3	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.34763369
4	protein neddylation (GO:0045116)	4.33499365
5	ATP synthesis coupled proton transport (GO:0015986)	4.28347296
6	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.28347296
7	cytidine metabolic process (GO:0046087)	4.14035904
8	cytidine catabolic process (GO:0006216)	4.14035904
9	cytidine deamination (GO:0009972)	4.14035904
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.02517843
11	ribosomal large subunit biogenesis (GO:0042273)	3.96923201
12	viral transcription (GO:0019083)	3.77227161
13	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.71494038
14	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.69076561
15	translational termination (GO:0006415)	3.67295389
16	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.53981415
17	maturation of SSU-rRNA (GO:0030490)	3.47240923
18	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.47102809
19	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.47102809
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.44171037
21	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.41658459
22	protein complex biogenesis (GO:0070271)	3.41556601
23	translational elongation (GO:0006414)	3.39849747
24	cotranslational protein targeting to membrane (GO:0006613)	3.35706214
25	protein targeting to ER (GO:0045047)	3.32805655
26	water-soluble vitamin biosynthetic process (GO:0042364)	3.27237584
27	protein localization to endoplasmic reticulum (GO:0070972)	3.20972704
28	NADH dehydrogenase complex assembly (GO:0010257)	3.20398919
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20398919
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20398919
31	behavioral response to nicotine (GO:0035095)	3.19953507
32	kynurenine metabolic process (GO:0070189)	3.18816155
33	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.16432152
34	mitochondrial respiratory chain complex assembly (GO:0033108)	3.13016805
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.12110870
36	electron transport chain (GO:0022900)	3.11331937
37	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.10716146
38	termination of RNA polymerase III transcription (GO:0006386)	3.10716146
39	respiratory electron transport chain (GO:0022904)	3.10710376
40	tryptophan catabolic process (GO:0006569)	3.04052011
41	indole-containing compound catabolic process (GO:0042436)	3.04052011
42	indolalkylamine catabolic process (GO:0046218)	3.04052011
43	rRNA catabolic process (GO:0016075)	3.03204851
44	respiratory chain complex IV assembly (GO:0008535)	3.03051466
45	proteasome assembly (GO:0043248)	2.99622114
46	chaperone-mediated protein transport (GO:0072321)	2.98863120
47	mannosylation (GO:0097502)	2.95757024
48	positive regulation of defense response to virus by host (GO:0002230)	2.90142157
49	translation (GO:0006412)	2.89131699
50	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.88210019
51	platelet dense granule organization (GO:0060155)	2.86996630
52	cytochrome complex assembly (GO:0017004)	2.85519808
53	translational initiation (GO:0006413)	2.81627331
54	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81045621
55	DNA double-strand break processing (GO:0000729)	2.80793779
56	response to pheromone (GO:0019236)	2.71987650
57	negative regulation of T cell differentiation in thymus (GO:0033085)	2.70850561
58	viral life cycle (GO:0019058)	2.69701533
59	regulation of cellular amino acid metabolic process (GO:0006521)	2.69225332
60	pseudouridine synthesis (GO:0001522)	2.69177611
61	rRNA metabolic process (GO:0016072)	2.69045522
62	rRNA processing (GO:0006364)	2.66631649
63	DNA demethylation (GO:0080111)	2.63071149
64	ubiquinone biosynthetic process (GO:0006744)	2.62773349
65	cellular protein complex disassembly (GO:0043624)	2.59622580
66	piRNA metabolic process (GO:0034587)	2.59178836
67	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	2.59158579
68	indolalkylamine metabolic process (GO:0006586)	2.59120218
69	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.59073450
70	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.56267753
71	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.55730725
72	aldehyde catabolic process (GO:0046185)	2.55528988
73	cellular component biogenesis (GO:0044085)	2.55191864
74	GPI anchor metabolic process (GO:0006505)	2.53092457
75	GTP biosynthetic process (GO:0006183)	2.52306271
76	ribosomal small subunit biogenesis (GO:0042274)	2.51971204
77	rRNA modification (GO:0000154)	2.51331231
78	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.51271475
79	tRNA processing (GO:0008033)	2.51172200
80	base-excision repair, AP site formation (GO:0006285)	2.50869553
81	negative regulation of mast cell activation (GO:0033004)	2.49197598
82	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.48859670
83	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.48859670
84	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.48859670
85	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.47070114
86	regulation of regulatory T cell differentiation (GO:0045589)	2.46475766
87	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.44397017
88	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.44397017
89	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.43046826
90	tryptophan metabolic process (GO:0006568)	2.42369139
91	aggressive behavior (GO:0002118)	2.42075122
92	GPI anchor biosynthetic process (GO:0006506)	2.40421650
93	positive regulation of prostaglandin secretion (GO:0032308)	2.40378377
94	ATP biosynthetic process (GO:0006754)	2.40122790
95	hydrogen ion transmembrane transport (GO:1902600)	2.40050593
96	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.39752457
97	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.39398212
98	L-fucose catabolic process (GO:0042355)	2.39137970
99	fucose catabolic process (GO:0019317)	2.39137970
100	L-fucose metabolic process (GO:0042354)	2.39137970

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.80301499
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.32732843
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.29392447
4	ZNF274_21170338_ChIP-Seq_K562_Hela	3.11984239
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.08025792
6	VDR_22108803_ChIP-Seq_LS180_Human	2.98223183
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.87792109
8	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.73421720
9	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.49316081
10	VDR_23849224_ChIP-Seq_CD4+_Human	2.38201738
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.34759185
12	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.31177489
13	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.17695713
14	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.15766480
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.15162374
16	IGF1R_20145208_ChIP-Seq_DFB_Human	2.14548409
17	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.09718445
18	ELK1_19687146_ChIP-ChIP_HELA_Human	2.01645698
19	EZH2_22144423_ChIP-Seq_EOC_Human	1.94615013
20	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.93131465
21	EWS_26573619_Chip-Seq_HEK293_Human	1.92562374
22	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.91428265
23	FOXP3_21729870_ChIP-Seq_TREG_Human	1.90476030
24	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.90196387
25	MYC_18940864_ChIP-ChIP_HL60_Human	1.81832843
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.80459768
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.72396969
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.71044144
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.65281820
30	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.62924197
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.62813165
32	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.61699399
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.59106260
34	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56836996
35	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.56114688
36	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.56020830
37	FUS_26573619_Chip-Seq_HEK293_Human	1.54983784
38	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.49043100
39	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.49043100
40	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.48643905
41	AR_20517297_ChIP-Seq_VCAP_Human	1.46609273
42	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.41126468
43	TAF15_26573619_Chip-Seq_HEK293_Human	1.37943513
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.37524765
45	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.37342643
46	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.36971394
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36922503
48	CBP_20019798_ChIP-Seq_JUKART_Human	1.36922503
49	ER_23166858_ChIP-Seq_MCF-7_Human	1.35133243
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32116116
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32116116
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.31413459
53	P300_19829295_ChIP-Seq_ESCs_Human	1.31394628
54	GATA3_26560356_Chip-Seq_TH2_Human	1.29103405
55	NCOR_22424771_ChIP-Seq_293T_Human	1.25707381
56	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.24863045
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.24621230
58	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.22602501
59	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.22569061
60	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.22494321
61	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.20886155
62	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.16942816
63	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.16877633
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.16823449
65	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.14891376
66	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.14741324
67	TAF2_19829295_ChIP-Seq_ESCs_Human	1.14264282
68	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.13507880
69	CREB1_15753290_ChIP-ChIP_HEK293T_Human	1.13426982
70	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.13336166
71	NANOG_20526341_ChIP-Seq_ESCs_Human	1.12715274
72	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10882225
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.09782150
74	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.09690114
75	TTF2_22483619_ChIP-Seq_HELA_Human	1.09394110
76	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08884692
77	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08142259
78	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.06413122
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.06374600
80	ERG_20517297_ChIP-Seq_VCAP_Human	1.05424663
81	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.05131016
82	GBX2_23144817_ChIP-Seq_PC3_Human	1.04146110
83	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.03801286
84	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.02885543
85	MYB_26560356_Chip-Seq_TH2_Human	1.01884762
86	HOXB7_26014856_ChIP-Seq_BT474_Human	1.01428346
87	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.00327359
88	MYC_19829295_ChIP-Seq_ESCs_Human	1.00206252
89	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.99436209
90	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.98417573
91	BCAT_22108803_ChIP-Seq_LS180_Human	0.97301046
92	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97232074
93	HTT_18923047_ChIP-ChIP_STHdh_Human	0.97101915
94	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.96700546
95	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.96268032
96	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.95830800
97	TCF4_22108803_ChIP-Seq_LS180_Human	0.95787178
98	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.95253395
99	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.94645810
100	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92574949

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	4.47250987
2	MP0005671_abnormal_response_to	3.40704289
3	MP0008877_abnormal_DNA_methylation	3.06184036
4	MP0001835_abnormal_antigen_presentation	2.79681690
5	MP0002102_abnormal_ear_morphology	2.48370758
6	MP0009379_abnormal_foot_pigmentation	2.43563965
7	MP0002138_abnormal_hepatobiliary_system	2.41828061
8	MP0003787_abnormal_imprinting	2.33843383
9	MP0006072_abnormal_retinal_apoptosis	2.12374410
10	MP0005646_abnormal_pituitary_gland	1.97386491
11	MP0008872_abnormal_physiological_respon	1.93591825
12	MP0008875_abnormal_xenobiotic_pharmacok	1.89781696
13	MP0005084_abnormal_gallbladder_morpholo	1.87780880
14	MP0005551_abnormal_eye_electrophysiolog	1.87155686
15	MP0005645_abnormal_hypothalamus_physiol	1.75634595
16	MP0008789_abnormal_olfactory_epithelium	1.69996551
17	MP0000372_irregular_coat_pigmentation	1.69365683
18	MP0002876_abnormal_thyroid_physiology	1.69266816
19	MP0002837_dystrophic_cardiac_calcinosis	1.65821661
20	MP0001968_abnormal_touch/_nociception	1.63727498
21	MP0009785_altered_susceptibility_to	1.61232050
22	MP0004147_increased_porphyrin_level	1.61178511
23	MP0004142_abnormal_muscle_tone	1.59950617
24	MP0004885_abnormal_endolymph	1.57184589
25	MP0002148_abnormal_hypersensitivity_rea	1.56727836
26	MP0001986_abnormal_taste_sensitivity	1.54333195
27	MP0001800_abnormal_humoral_immune	1.54276211
28	MP0009333_abnormal_splenocyte_physiolog	1.51482926
29	MP0003646_muscle_fatigue	1.49702188
30	MP0003806_abnormal_nucleotide_metabolis	1.48156910
31	MP0001873_stomach_inflammation	1.40391497
32	MP0005075_abnormal_melanosome_morpholog	1.37712904
33	MP0002736_abnormal_nociception_after	1.36540928
34	MP0005253_abnormal_eye_physiology	1.34485976
35	MP0003880_abnormal_central_pattern	1.31874014
36	MP0008995_early_reproductive_senescence	1.31839134
37	MP0002160_abnormal_reproductive_system	1.31457045
38	MP0005389_reproductive_system_phenotype	1.29708599
39	MP0003786_premature_aging	1.29070095
40	MP0000685_abnormal_immune_system	1.27550454
41	MP0003195_calcinosis	1.27280752
42	MP0002166_altered_tumor_susceptibility	1.27075925
43	MP0006276_abnormal_autonomic_nervous	1.27051502
44	MP0002163_abnormal_gland_morphology	1.26597030
45	MP0002006_tumorigenesis	1.26068384
46	MP0004145_abnormal_muscle_electrophysio	1.24974090
47	MP0005000_abnormal_immune_tolerance	1.24065057
48	MP0003878_abnormal_ear_physiology	1.23984293
49	MP0005377_hearing/vestibular/ear_phenot	1.23984293
50	MP0002638_abnormal_pupillary_reflex	1.21536857
51	MP0001790_abnormal_immune_system	1.20354525
52	MP0005387_immune_system_phenotype	1.20354525
53	MP0002723_abnormal_immune_serum	1.19738055
54	MP0008058_abnormal_DNA_repair	1.19200334
55	MP0001764_abnormal_homeostasis	1.17391942
56	MP0001905_abnormal_dopamine_level	1.16640352
57	MP0001293_anophthalmia	1.13545938
58	MP0003011_delayed_dark_adaptation	1.10684698
59	MP0002938_white_spotting	1.10069034
60	MP0000631_abnormal_neuroendocrine_gland	1.07112556
61	MP0002420_abnormal_adaptive_immunity	1.06698033
62	MP0001919_abnormal_reproductive_system	1.05727270
63	MP0001819_abnormal_immune_cell	1.05460362
64	MP0003763_abnormal_thymus_physiology	1.02524353
65	MP0006036_abnormal_mitochondrial_physio	1.00093017
66	MP0002452_abnormal_antigen_presenting	0.99189154
67	MP0002272_abnormal_nervous_system	0.99171453
68	MP0005394_taste/olfaction_phenotype	0.97808464
69	MP0005499_abnormal_olfactory_system	0.97808464
70	MP0002234_abnormal_pharynx_morphology	0.97773023
71	MP0001485_abnormal_pinna_reflex	0.96835869
72	MP0003567_abnormal_fetal_cardiomyocyte	0.96091303
73	MP0002095_abnormal_skin_pigmentation	0.95203806
74	MP0001529_abnormal_vocalization	0.92929021
75	MP0009764_decreased_sensitivity_to	0.92259438
76	MP0003718_maternal_effect	0.91619048
77	MP0002277_abnormal_respiratory_mucosa	0.91496411
78	MP0003866_abnormal_defecation	0.89345482
79	MP0003252_abnormal_bile_duct	0.87844053
80	MP0005410_abnormal_fertilization	0.86321091
81	MP0003121_genomic_imprinting	0.85963776
82	MP0010155_abnormal_intestine_physiology	0.85714046
83	MP0003186_abnormal_redox_activity	0.84446281
84	MP0000716_abnormal_immune_system	0.82328733
85	MP0005025_abnormal_response_to	0.82073032
86	MP0005195_abnormal_posterior_eye	0.81249433
87	MP0002398_abnormal_bone_marrow	0.80158062
88	MP0005085_abnormal_gallbladder_physiolo	0.79854697
89	MP0005636_abnormal_mineral_homeostasis	0.79753231
90	MP0000689_abnormal_spleen_morphology	0.79505476
91	MP0001984_abnormal_olfaction	0.78963410
92	MP0002733_abnormal_thermal_nociception	0.77497701
93	MP0001970_abnormal_pain_threshold	0.77232600
94	MP0001440_abnormal_grooming_behavior	0.75483286
95	MP0009745_abnormal_behavioral_response	0.75346085
96	MP0000049_abnormal_middle_ear	0.72425424
97	MP0004742_abnormal_vestibular_system	0.72127393
98	MP0002405_respiratory_system_inflammati	0.71839488
99	MP0001119_abnormal_female_reproductive	0.70649905
100	MP0001845_abnormal_inflammatory_respons	0.70198006

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent rod-and cone-mediated responses on ERG (HP:0007688)	4.13291917
2	Acute necrotizing encephalopathy (HP:0006965)	4.04418549
3	Congenital stationary night blindness (HP:0007642)	3.88648194
4	Abnormal rod and cone electroretinograms (HP:0008323)	3.60353800
5	Acute encephalopathy (HP:0006846)	3.58059230
6	Pancreatic cysts (HP:0001737)	3.57292782
7	Mitochondrial inheritance (HP:0001427)	3.55506295
8	Abnormal mitochondria in muscle tissue (HP:0008316)	3.51488507
9	Progressive macrocephaly (HP:0004481)	3.42994081
10	Increased CSF lactate (HP:0002490)	3.28965841
11	IgG deficiency (HP:0004315)	3.28619116
12	Abnormality of midbrain morphology (HP:0002418)	3.22937836
13	Molar tooth sign on MRI (HP:0002419)	3.22937836
14	Pancreatic fibrosis (HP:0100732)	3.20948905
15	True hermaphroditism (HP:0010459)	3.14346157
16	Decreased central vision (HP:0007663)	3.09122302
17	Hypoproteinemia (HP:0003075)	3.02834723
18	Aplastic anemia (HP:0001915)	3.02711674
19	Hepatocellular necrosis (HP:0001404)	2.98587032
20	3-Methylglutaconic aciduria (HP:0003535)	2.93472093
21	Severe combined immunodeficiency (HP:0004430)	2.89520211
22	Abolished electroretinogram (ERG) (HP:0000550)	2.87453568
23	Attenuation of retinal blood vessels (HP:0007843)	2.86262046
24	Cerebral edema (HP:0002181)	2.83335880
25	Hepatic necrosis (HP:0002605)	2.81365849
26	Nephronophthisis (HP:0000090)	2.80764582
27	Abnormality of B cell number (HP:0010975)	2.74422593
28	Thyroiditis (HP:0100646)	2.67474887
29	Methylmalonic acidemia (HP:0002912)	2.67182414
30	Optic disc pallor (HP:0000543)	2.65918278
31	Abnormality of cells of the erythroid lineage (HP:0012130)	2.65353174
32	Stomatitis (HP:0010280)	2.62305864
33	Increased hepatocellular lipid droplets (HP:0006565)	2.57651497
34	Elevated erythrocyte sedimentation rate (HP:0003565)	2.55927159
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.50705636
36	Pendular nystagmus (HP:0012043)	2.49729236
37	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.47647205
38	Absent/shortened dynein arms (HP:0200106)	2.47647205
39	Reticulocytopenia (HP:0001896)	2.45281588
40	Abnormality of the prostate (HP:0008775)	2.42727045
41	B lymphocytopenia (HP:0010976)	2.41430161
42	Lipid accumulation in hepatocytes (HP:0006561)	2.40753376
43	Renal cortical cysts (HP:0000803)	2.38394676
44	Abnormality of the renal cortex (HP:0011035)	2.38337744
45	Increased serum lactate (HP:0002151)	2.33198208
46	Abnormality of the renal medulla (HP:0100957)	2.29802723
47	Abnormal number of erythroid precursors (HP:0012131)	2.29688270
48	Panhypogammaglobulinemia (HP:0003139)	2.27006517
49	Congenital, generalized hypertrichosis (HP:0004540)	2.21890331
50	Increased IgM level (HP:0003496)	2.19399688
51	Methylmalonic aciduria (HP:0012120)	2.17316946
52	Medial flaring of the eyebrow (HP:0010747)	2.17072249
53	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.16757362
54	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.16757362
55	Increased intramyocellular lipid droplets (HP:0012240)	2.15923080
56	Lethargy (HP:0001254)	2.15006963
57	Renal Fanconi syndrome (HP:0001994)	2.13768126
58	Constricted visual fields (HP:0001133)	2.13012563
59	Lactic acidosis (HP:0003128)	2.12638428
60	Combined immunodeficiency (HP:0005387)	2.10844584
61	Abnormality of T cell number (HP:0011839)	2.10808880
62	Type II lissencephaly (HP:0007260)	2.09163998
63	Hyperglycinemia (HP:0002154)	2.07850782
64	Type 2 muscle fiber atrophy (HP:0003554)	2.07397183
65	Stenosis of the external auditory canal (HP:0000402)	2.06566643
66	Macrocytic anemia (HP:0001972)	2.05996223
67	T lymphocytopenia (HP:0005403)	2.02837191
68	Keratoconus (HP:0000563)	2.01208542
69	Increased corneal curvature (HP:0100692)	2.01208542
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99840807
71	Cystic liver disease (HP:0006706)	1.99407227
72	Abnormality of eosinophils (HP:0001879)	1.97955240
73	Hyperglycinuria (HP:0003108)	1.97313910
74	Pancytopenia (HP:0001876)	1.93214114
75	Sclerocornea (HP:0000647)	1.90082495
76	Asplenia (HP:0001746)	1.89733573
77	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88380113
78	Abnormal respiratory epithelium morphology (HP:0012253)	1.88380113
79	Absent thumb (HP:0009777)	1.86853022
80	Agammaglobulinemia (HP:0004432)	1.84335598
81	Abnormality of serine family amino acid metabolism (HP:0010894)	1.83450245
82	Abnormality of glycine metabolism (HP:0010895)	1.83450245
83	Abnormality of T cells (HP:0002843)	1.81553678
84	Aplasia/hypoplasia of the uterus (HP:0008684)	1.79892954
85	Exertional dyspnea (HP:0002875)	1.77974757
86	Respiratory failure (HP:0002878)	1.77718441
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.76411141
88	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.76024277
89	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.74672338
90	Male pseudohermaphroditism (HP:0000037)	1.74341577
91	Leukodystrophy (HP:0002415)	1.74269203
92	Generalized aminoaciduria (HP:0002909)	1.74167490
93	Abnormal drinking behavior (HP:0030082)	1.73428687
94	Polydipsia (HP:0001959)	1.73428687
95	Glycosuria (HP:0003076)	1.72661008
96	Abnormality of urine glucose concentration (HP:0011016)	1.72661008
97	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.71888384
98	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.71314941
99	Increased muscle lipid content (HP:0009058)	1.70781262
100	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.70512758

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TXK	4.01256057
2	NUAK1	3.04900456
3	CDK19	2.88150813
4	BCKDK	2.77663061
5	ZAK	2.67461172
6	ADRBK2	2.60961486
7	GRK1	2.59753580
8	FRK	2.52292966
9	MAP4K2	2.48627095
10	TAOK3	2.39217682
11	VRK2	2.33734422
12	TLK1	2.18404742
13	EIF2AK3	2.05096194
14	STK16	1.92792210
15	KDR	1.82404423
16	TIE1	1.64520716
17	PINK1	1.63668742
18	MAP4K1	1.61922278
19	WNK4	1.57991720
20	PASK	1.49978053
21	VRK1	1.47091996
22	ITK	1.46245518
23	FES	1.37528042
24	MAP3K12	1.36847627
25	TEC	1.35589383
26	OXSR1	1.35406538
27	WNK3	1.35383008
28	KIT	1.31491446
29	MST4	1.30799465
30	BMPR1B	1.25972241
31	CAMKK2	1.14823437
32	SYK	1.14518810
33	DYRK2	1.13754589
34	INSRR	1.12320281
35	IKBKB	1.07479898
36	MAPK13	1.03658898
37	MUSK	0.98667667
38	STK39	0.97313527
39	BMPR2	0.96312223
40	PIK3CA	0.95778805
41	MKNK1	0.93498863
42	PRKCQ	0.89130257
43	CSF1R	0.88226595
44	TESK2	0.80766700
45	SRPK1	0.80354778
46	DAPK1	0.76566249
47	PIK3CG	0.76523183
48	TRIM28	0.74986343
49	LYN	0.72039875
50	PLK3	0.71734500
51	GRK6	0.70801003
52	MYLK	0.69465441
53	ADRBK1	0.69320797
54	BTK	0.69017761
55	LCK	0.68748750
56	EIF2AK1	0.68488355
57	BUB1	0.67508294
58	PLK2	0.65968094
59	DAPK2	0.63764568
60	RPS6KA5	0.63024842
61	ERBB3	0.62148411
62	TAF1	0.62079412
63	PRKCE	0.61232935
64	MATK	0.59528191
65	MKNK2	0.59014348
66	FLT3	0.58376241
67	MAP3K4	0.58126850
68	PLK4	0.57412386
69	CSNK1G3	0.57014405
70	MAPKAPK3	0.56076441
71	IGF1R	0.55669726
72	PHKG2	0.52597184
73	PHKG1	0.52597184
74	OBSCN	0.50443846
75	NME1	0.49315829
76	PBK	0.49194150
77	MAP2K7	0.48857375
78	CAMKK1	0.48067333
79	CSNK1G2	0.46643657
80	CSNK2A2	0.46192354
81	PRKACA	0.45846898
82	PRKCG	0.45126449
83	MAPKAPK5	0.44732780
84	ATR	0.43822177
85	PRKCA	0.43801544
86	JAK3	0.43172568
87	LIMK1	0.42943307
88	DAPK3	0.42580483
89	EIF2AK2	0.41574465
90	CSNK1G1	0.41307643
91	TNK2	0.41040983
92	CSNK2A1	0.40883084
93	MAP2K6	0.38833446
94	CSNK1A1L	0.38448982
95	PLK1	0.37941043
96	AURKB	0.37616519
97	IKBKE	0.37544980
98	CDC7	0.37275712
99	NME2	0.36686753
100	RPS6KB2	0.36480785

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	3.39920657
2	Proteasome_Homo sapiens_hsa03050	3.27331674
3	Asthma_Homo sapiens_hsa05310	3.17118578
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.95111588
5	Allograft rejection_Homo sapiens_hsa05330	2.93897902
6	Autoimmune thyroid disease_Homo sapiens_hsa05320	2.76542122
7	Primary immunodeficiency_Homo sapiens_hsa05340	2.71586672
8	Graft-versus-host disease_Homo sapiens_hsa05332	2.60471236
9	Intestinal immune network for IgA production_Homo sapiens_hsa04672	2.57008334
10	Protein export_Homo sapiens_hsa03060	2.43641306
11	Type I diabetes mellitus_Homo sapiens_hsa04940	2.40219543
12	Parkinsons disease_Homo sapiens_hsa05012	2.37053877
13	RNA polymerase_Homo sapiens_hsa03020	2.10916039
14	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.96899186
15	Phototransduction_Homo sapiens_hsa04744	1.77545535
16	Linoleic acid metabolism_Homo sapiens_hsa00591	1.73726360
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.72837015
18	Caffeine metabolism_Homo sapiens_hsa00232	1.69660395
19	RNA degradation_Homo sapiens_hsa03018	1.67740263
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.60730850
21	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.60013879
22	Homologous recombination_Homo sapiens_hsa03440	1.59009374
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.58855674
24	Alzheimers disease_Homo sapiens_hsa05010	1.48668165
25	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.48091212
26	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.45562908
27	Huntingtons disease_Homo sapiens_hsa05016	1.43336186
28	One carbon pool by folate_Homo sapiens_hsa00670	1.37584542
29	Propanoate metabolism_Homo sapiens_hsa00640	1.37483714
30	Basal transcription factors_Homo sapiens_hsa03022	1.35473320
31	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.34654719
32	Cardiac muscle contraction_Homo sapiens_hsa04260	1.32167556
33	Rheumatoid arthritis_Homo sapiens_hsa05323	1.31662931
34	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29158111
35	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22573925
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.20677503
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.12176784
38	Pyrimidine metabolism_Homo sapiens_hsa00240	1.11523748
39	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.09013201
40	Mismatch repair_Homo sapiens_hsa03430	1.03593451
41	Butanoate metabolism_Homo sapiens_hsa00650	1.03018689
42	Peroxisome_Homo sapiens_hsa04146	0.99901628
43	Nucleotide excision repair_Homo sapiens_hsa03420	0.98677635
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.97992468
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96989792
46	RNA transport_Homo sapiens_hsa03013	0.96068127
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.95481381
48	Olfactory transduction_Homo sapiens_hsa04740	0.93638640
49	Purine metabolism_Homo sapiens_hsa00230	0.89570879
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.88746709
51	Regulation of autophagy_Homo sapiens_hsa04140	0.83955735
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.83510028
53	Chemical carcinogenesis_Homo sapiens_hsa05204	0.81788328
54	Viral myocarditis_Homo sapiens_hsa05416	0.81721669
55	Base excision repair_Homo sapiens_hsa03410	0.81149326
56	Spliceosome_Homo sapiens_hsa03040	0.80211564
57	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.79256227
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.79129330
59	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.78478424
60	Retinol metabolism_Homo sapiens_hsa00830	0.75968054
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.74615381
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.72741180
63	Selenocompound metabolism_Homo sapiens_hsa00450	0.71124553
64	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70821721
65	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.70475245
66	DNA replication_Homo sapiens_hsa03030	0.69200952
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.67116874
68	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.66845548
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.65117391
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.64120326
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.63920667
72	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.63903041
73	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.60924039
74	Non-homologous end-joining_Homo sapiens_hsa03450	0.60252253
75	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.59949087
76	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.59738725
77	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58122025
78	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.56502330
79	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.56053109
80	Metabolic pathways_Homo sapiens_hsa01100	0.55701571
81	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.53470622
82	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.51972601
83	Steroid biosynthesis_Homo sapiens_hsa00100	0.49389643
84	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.45775535
85	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.45027849
86	Taste transduction_Homo sapiens_hsa04742	0.44233514
87	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.40769660
88	Fat digestion and absorption_Homo sapiens_hsa04975	0.40518179
89	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.40494685
90	Collecting duct acid secretion_Homo sapiens_hsa04966	0.40456944
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38858249
92	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.37433162
93	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.35961735
94	Sulfur metabolism_Homo sapiens_hsa00920	0.32448914
95	Fatty acid elongation_Homo sapiens_hsa00062	0.31814267
96	Nicotine addiction_Homo sapiens_hsa05033	0.31300179
97	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.26741909
98	Herpes simplex infection_Homo sapiens_hsa05168	0.26686518
99	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.26574844
100	Fatty acid degradation_Homo sapiens_hsa00071	0.25689755

RPL7P23

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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