RPL7P24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.40609502
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.06192344
3ATP synthesis coupled proton transport (GO:0015986)4.06192344
4ribosomal small subunit assembly (GO:0000028)3.93349075
5response to pheromone (GO:0019236)3.76987187
6indolalkylamine metabolic process (GO:0006586)3.69438073
7mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.64009647
8protein complex biogenesis (GO:0070271)3.61679230
9tryptophan metabolic process (GO:0006568)3.60453579
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.59668958
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.59668958
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.49438906
13protein neddylation (GO:0045116)3.41925575
14kynurenine metabolic process (GO:0070189)3.38361122
15exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.37613238
16nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37451741
17behavioral response to nicotine (GO:0035095)3.33165657
18mitochondrial respiratory chain complex I assembly (GO:0032981)3.29228928
19NADH dehydrogenase complex assembly (GO:0010257)3.29228928
20mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.29228928
21mitochondrial respiratory chain complex assembly (GO:0033108)3.21525862
22viral transcription (GO:0019083)3.18192826
23L-fucose catabolic process (GO:0042355)3.13657472
24fucose catabolic process (GO:0019317)3.13657472
25L-fucose metabolic process (GO:0042354)3.13657472
26establishment of protein localization to mitochondrial membrane (GO:0090151)3.12976905
27translational termination (GO:0006415)3.09885626
28maturation of SSU-rRNA (GO:0030490)3.08687160
29ribosomal large subunit biogenesis (GO:0042273)3.04889197
30tryptophan catabolic process (GO:0006569)3.04193498
31indole-containing compound catabolic process (GO:0042436)3.04193498
32indolalkylamine catabolic process (GO:0046218)3.04193498
33SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02532427
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.01156459
35electron transport chain (GO:0022900)3.00732156
36protein-cofactor linkage (GO:0018065)3.00547595
37respiratory electron transport chain (GO:0022904)3.00043936
38cotranslational protein targeting to membrane (GO:0006613)2.99064054
39protein targeting to ER (GO:0045047)2.98876091
40positive regulation of defense response to virus by host (GO:0002230)2.98565242
41preassembly of GPI anchor in ER membrane (GO:0016254)2.97164572
42RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93957737
43cytochrome complex assembly (GO:0017004)2.93420473
44water-soluble vitamin biosynthetic process (GO:0042364)2.92990099
45negative regulation of T cell differentiation in thymus (GO:0033085)2.92362065
46negative regulation of mast cell activation (GO:0033004)2.90834706
47piRNA metabolic process (GO:0034587)2.89804878
48respiratory chain complex IV assembly (GO:0008535)2.88252008
49protein localization to endoplasmic reticulum (GO:0070972)2.87170123
50establishment of protein localization to endoplasmic reticulum (GO:0072599)2.82002670
51positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.81363378
52cellular response to exogenous dsRNA (GO:0071360)2.80841163
53regulation of thymocyte apoptotic process (GO:0070243)2.80495665
54translational elongation (GO:0006414)2.79906934
55positive regulation of prostaglandin secretion (GO:0032308)2.79556533
56ubiquinone biosynthetic process (GO:0006744)2.71224796
57iron-sulfur cluster assembly (GO:0016226)2.68080155
58metallo-sulfur cluster assembly (GO:0031163)2.68080155
59positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.68056642
60regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.67859591
61regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.65969105
62regulation of memory T cell differentiation (GO:0043380)2.65559081
63cellular response to interferon-beta (GO:0035458)2.65280196
64positive regulation of T-helper 1 type immune response (GO:0002827)2.62321807
65positive regulation of alpha-beta T cell proliferation (GO:0046641)2.61926385
66positive regulation of fatty acid transport (GO:2000193)2.60382877
67cytidine metabolic process (GO:0046087)2.59592414
68cytidine catabolic process (GO:0006216)2.59592414
69cytidine deamination (GO:0009972)2.59592414
70rRNA catabolic process (GO:0016075)2.57419617
71auditory receptor cell stereocilium organization (GO:0060088)2.56512250
72termination of RNA polymerase III transcription (GO:0006386)2.56239010
73transcription elongation from RNA polymerase III promoter (GO:0006385)2.56239010
74proteasome assembly (GO:0043248)2.55581164
75chaperone-mediated protein transport (GO:0072321)2.55561644
76pseudouridine synthesis (GO:0001522)2.55455758
77indole-containing compound metabolic process (GO:0042430)2.55401901
78positive regulation of protein homodimerization activity (GO:0090073)2.53279823
79regulation of regulatory T cell differentiation (GO:0045589)2.50135360
80rRNA modification (GO:0000154)2.49624329
81detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.49281974
82response to interferon-beta (GO:0035456)2.47009279
83ubiquinone metabolic process (GO:0006743)2.46347352
84tRNA processing (GO:0008033)2.45953295
85positive regulation of T cell apoptotic process (GO:0070234)2.44026276
86regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.43886675
87translation (GO:0006412)2.43427661
88regulation of cellular amino acid metabolic process (GO:0006521)2.43302769
89GPI anchor biosynthetic process (GO:0006506)2.39087154
90maturation of 5.8S rRNA (GO:0000460)2.38667517
91negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.38090631
92GPI anchor metabolic process (GO:0006505)2.37999002
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.37865984
94mannosylation (GO:0097502)2.36733521
95proton transport (GO:0015992)2.35576756
96hydrogen transport (GO:0006818)2.35218336
97regulation of cilium movement (GO:0003352)2.33944072
98primary amino compound metabolic process (GO:1901160)2.33006937
99somite development (GO:0061053)2.32978122
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.32841165

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.52963295
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.48642587
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.34952116
4ZNF274_21170338_ChIP-Seq_K562_Hela3.23165410
5EST1_17652178_ChIP-ChIP_JURKAT_Human2.75851386
6VDR_22108803_ChIP-Seq_LS180_Human2.66882670
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.66211978
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.59309174
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44969145
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.27737126
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.24417994
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.22976205
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.20219683
14VDR_23849224_ChIP-Seq_CD4+_Human2.18752028
15IGF1R_20145208_ChIP-Seq_DFB_Human2.13891906
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10761392
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01562703
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94455850
19ELK1_19687146_ChIP-ChIP_HELA_Human1.85788507
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.83061323
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82715667
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81756293
23EWS_26573619_Chip-Seq_HEK293_Human1.78944418
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76010801
25MYC_18940864_ChIP-ChIP_HL60_Human1.75587655
26EZH2_22144423_ChIP-Seq_EOC_Human1.72040683
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.70942517
28TP53_22573176_ChIP-Seq_HFKS_Human1.68059696
29FOXP3_21729870_ChIP-Seq_TREG_Human1.63928900
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59046104
31NOTCH1_21737748_ChIP-Seq_TLL_Human1.58225373
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57866853
33PCGF2_27294783_Chip-Seq_NPCs_Mouse1.56512514
34ER_23166858_ChIP-Seq_MCF-7_Human1.55092186
35FUS_26573619_Chip-Seq_HEK293_Human1.53430301
36GATA3_26560356_Chip-Seq_TH2_Human1.53019944
37AR_20517297_ChIP-Seq_VCAP_Human1.49588257
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46556432
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46421994
40FOXA1_27270436_Chip-Seq_PROSTATE_Human1.45173487
41FOXA1_25329375_ChIP-Seq_VCAP_Human1.45173487
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44522194
43P300_19829295_ChIP-Seq_ESCs_Human1.42419422
44GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.41386971
45IRF1_19129219_ChIP-ChIP_H3396_Human1.38455463
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.38226506
47TAF15_26573619_Chip-Seq_HEK293_Human1.37669288
48GATA3_21878914_ChIP-Seq_MCF-7_Human1.37250385
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33983568
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.33682243
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31055781
52FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30475730
53NFE2_27457419_Chip-Seq_LIVER_Mouse1.29955332
54SOX2_19829295_ChIP-Seq_ESCs_Human1.27874484
55NANOG_19829295_ChIP-Seq_ESCs_Human1.27874484
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.26900770
57ETV2_25802403_ChIP-Seq_MESCs_Mouse1.25328260
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23436739
59NCOR_22424771_ChIP-Seq_293T_Human1.23341100
60CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21892749
61AUTS2_25519132_ChIP-Seq_293T-REX_Human1.20443853
62CBP_20019798_ChIP-Seq_JUKART_Human1.17076794
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17076794
64PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13452008
65MYB_26560356_Chip-Seq_TH2_Human1.13342483
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11712713
67LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11179757
68HOXB7_26014856_ChIP-Seq_BT474_Human1.10846915
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.10284870
70KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08701488
71TAF2_19829295_ChIP-Seq_ESCs_Human1.08185322
72CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.07778182
73TCF4_22108803_ChIP-Seq_LS180_Human1.07357244
74GBX2_23144817_ChIP-Seq_PC3_Human1.07290221
75FOXH1_21741376_ChIP-Seq_EPCs_Human1.07216126
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07079547
77ERG_20517297_ChIP-Seq_VCAP_Human1.06823374
78TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.06547620
79FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06529609
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.03727865
81MYC_19829295_ChIP-Seq_ESCs_Human1.02998389
82BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02971786
83PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02946339
84GATA6_21074721_ChIP-Seq_CACO-2_Human1.01907098
85PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99917194
86GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.98247416
87NANOG_20526341_ChIP-Seq_ESCs_Human0.97289621
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97132582
89RBPJ_21746931_ChIP-Seq_IB4_Human0.96776574
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.95877261
91CRX_20693478_ChIP-Seq_RETINA_Mouse0.95001046
92HOXB4_20404135_ChIP-ChIP_EML_Mouse0.94894738
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.93718154
94GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93716178
95MYC_18555785_ChIP-Seq_MESCs_Mouse0.93604013
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.93559180
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92885982
98EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92248905
99TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90574661
100GATA3_27048872_Chip-Seq_THYMUS_Human0.90073428

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.59348620
2MP0005671_abnormal_response_to3.06770152
3MP0006292_abnormal_olfactory_placode2.75109216
4MP0002138_abnormal_hepatobiliary_system2.65665656
5MP0008875_abnormal_xenobiotic_pharmacok2.58670944
6MP0003195_calcinosis2.43277172
7MP0008877_abnormal_DNA_methylation2.40524227
8MP0002102_abnormal_ear_morphology2.39698140
9MP0000372_irregular_coat_pigmentation2.39247919
10MP0002166_altered_tumor_susceptibility2.29660311
11MP0005646_abnormal_pituitary_gland2.24083937
12MP0008872_abnormal_physiological_respon2.22627055
13MP0003646_muscle_fatigue2.16457905
14MP0002006_tumorigenesis2.10692482
15MP0002148_abnormal_hypersensitivity_rea2.05113444
16MP0000685_abnormal_immune_system2.04991194
17MP0009379_abnormal_foot_pigmentation1.90865065
18MP0003806_abnormal_nucleotide_metabolis1.88084628
19MP0009785_altered_susceptibility_to1.87828525
20MP0001800_abnormal_humoral_immune1.85761599
21MP0005645_abnormal_hypothalamus_physiol1.82229121
22MP0001968_abnormal_touch/_nociception1.80028480
23MP0003787_abnormal_imprinting1.79870825
24MP0005387_immune_system_phenotype1.73125550
25MP0001790_abnormal_immune_system1.73125550
26MP0002837_dystrophic_cardiac_calcinosis1.71032923
27MP0004147_increased_porphyrin_level1.67160718
28MP0002876_abnormal_thyroid_physiology1.66966193
29MP0003724_increased_susceptibility_to1.65803884
30MP0005551_abnormal_eye_electrophysiolog1.63910058
31MP0006072_abnormal_retinal_apoptosis1.61050173
32MP0006276_abnormal_autonomic_nervous1.60969113
33MP0001986_abnormal_taste_sensitivity1.50316632
34MP0009764_decreased_sensitivity_to1.50131092
35MP0004142_abnormal_muscle_tone1.48135861
36MP0005000_abnormal_immune_tolerance1.47665176
37MP0008789_abnormal_olfactory_epithelium1.45884819
38MP0002723_abnormal_immune_serum1.42673951
39MP0005171_absent_coat_pigmentation1.36129910
40MP0002452_abnormal_antigen_presenting1.33220270
41MP0004885_abnormal_endolymph1.30192947
42MP0009333_abnormal_splenocyte_physiolog1.30049786
43MP0005084_abnormal_gallbladder_morpholo1.25277576
44MP0005389_reproductive_system_phenotype1.24111478
45MP0004742_abnormal_vestibular_system1.23313687
46MP0005075_abnormal_melanosome_morpholog1.21793713
47MP0004145_abnormal_muscle_electrophysio1.21154365
48MP0009278_abnormal_bone_marrow1.20670619
49MP0005167_abnormal_blood-brain_barrier1.19595838
50MP0008775_abnormal_heart_ventricle1.18965797
51MP0001905_abnormal_dopamine_level1.18159003
52MP0006082_CNS_inflammation1.16155978
53MP0002420_abnormal_adaptive_immunity1.15922717
54MP0001819_abnormal_immune_cell1.15767215
55MP0001984_abnormal_olfaction1.15490462
56MP0000569_abnormal_digit_pigmentation1.12980021
57MP0002736_abnormal_nociception_after1.12506702
58MP0002653_abnormal_ependyma_morphology1.10576141
59MP0008995_early_reproductive_senescence1.10027176
60MP0005377_hearing/vestibular/ear_phenot1.09386255
61MP0003878_abnormal_ear_physiology1.09386255
62MP0002160_abnormal_reproductive_system1.05050338
63MP0010155_abnormal_intestine_physiology1.03979619
64MP0003186_abnormal_redox_activity1.03580580
65MP0001501_abnormal_sleep_pattern1.03349174
66MP0002095_abnormal_skin_pigmentation1.01991108
67MP0003763_abnormal_thymus_physiology1.01223923
68MP0006036_abnormal_mitochondrial_physio1.00972484
69MP0000230_abnormal_systemic_arterial1.00779131
70MP0001919_abnormal_reproductive_system1.00461468
71MP0005025_abnormal_response_to1.00378745
72MP0002638_abnormal_pupillary_reflex0.98584391
73MP0003786_premature_aging0.97483393
74MP0001485_abnormal_pinna_reflex0.97002059
75MP0002163_abnormal_gland_morphology0.96476314
76MP0003252_abnormal_bile_duct0.94217206
77MP0003880_abnormal_central_pattern0.94032781
78MP0003866_abnormal_defecation0.93385482
79MP0009745_abnormal_behavioral_response0.93077877
80MP0002272_abnormal_nervous_system0.91151762
81MP0008058_abnormal_DNA_repair0.90425923
82MP0000427_abnormal_hair_cycle0.89889970
83MP0005253_abnormal_eye_physiology0.86307574
84MP0000716_abnormal_immune_system0.84753177
85MP0002933_joint_inflammation0.83805825
86MP0005499_abnormal_olfactory_system0.82868971
87MP0005394_taste/olfaction_phenotype0.82868971
88MP0001970_abnormal_pain_threshold0.80401919
89MP0002733_abnormal_thermal_nociception0.80302917
90MP0005410_abnormal_fertilization0.80178860
91MP0002234_abnormal_pharynx_morphology0.80084261
92MP0009697_abnormal_copulation0.76606922
93MP0002398_abnormal_bone_marrow0.76388223
94MP0002277_abnormal_respiratory_mucosa0.76172973
95MP0001845_abnormal_inflammatory_respons0.74712243
96MP0001529_abnormal_vocalization0.74230723
97MP0005636_abnormal_mineral_homeostasis0.73364953
98MP0003121_genomic_imprinting0.71354477
99MP0000689_abnormal_spleen_morphology0.70125381
100MP0003436_decreased_susceptibility_to0.69718434

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.19538996
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.92823642
3Abnormality of B cell number (HP:0010975)3.72429974
4Acute necrotizing encephalopathy (HP:0006965)3.72045953
5B lymphocytopenia (HP:0010976)3.71745062
6Mitochondrial inheritance (HP:0001427)3.64425823
7Abolished electroretinogram (ERG) (HP:0000550)3.52827517
8Increased CSF lactate (HP:0002490)3.45802867
9Panhypogammaglobulinemia (HP:0003139)3.45475358
10Abnormal rod and cone electroretinograms (HP:0008323)3.42517149
11Pancreatic cysts (HP:0001737)3.42417353
123-Methylglutaconic aciduria (HP:0003535)3.39155484
13IgG deficiency (HP:0004315)3.36491641
14Stomatitis (HP:0010280)3.35977989
15Congenital stationary night blindness (HP:0007642)3.30798690
16Abnormality of midbrain morphology (HP:0002418)3.29642697
17Molar tooth sign on MRI (HP:0002419)3.29642697
18Progressive macrocephaly (HP:0004481)3.25705865
19Acute encephalopathy (HP:0006846)3.23330507
20Hypoproteinemia (HP:0003075)3.17756992
21Increased hepatocellular lipid droplets (HP:0006565)3.16713147
22Abnormal mitochondria in muscle tissue (HP:0008316)3.15121593
23Hepatocellular necrosis (HP:0001404)3.12290256
24Decreased central vision (HP:0007663)3.06761577
25Severe combined immunodeficiency (HP:0004430)3.06362903
26Pancreatic fibrosis (HP:0100732)3.04504143
27Congenital, generalized hypertrichosis (HP:0004540)3.03679219
28Nephronophthisis (HP:0000090)3.02279431
29Lipid accumulation in hepatocytes (HP:0006561)3.01434783
30Thyroiditis (HP:0100646)2.96076872
31Hepatic necrosis (HP:0002605)2.78053300
32Hypothermia (HP:0002045)2.74608271
33Abnormality of the prostate (HP:0008775)2.73868246
34Pendular nystagmus (HP:0012043)2.72070552
35True hermaphroditism (HP:0010459)2.70753770
36Type II lissencephaly (HP:0007260)2.68855180
37Abnormality of the renal medulla (HP:0100957)2.64492726
38Attenuation of retinal blood vessels (HP:0007843)2.52176180
39Stenosis of the external auditory canal (HP:0000402)2.45447197
40Type 2 muscle fiber atrophy (HP:0003554)2.44976946
41Abnormality of the renal cortex (HP:0011035)2.44245020
42Cerebral edema (HP:0002181)2.41993834
43Renal Fanconi syndrome (HP:0001994)2.38191009
44Increased serum lactate (HP:0002151)2.37911474
45Optic disc pallor (HP:0000543)2.33221827
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.28581890
47Absent/shortened dynein arms (HP:0200106)2.28581890
48T lymphocytopenia (HP:0005403)2.28457274
49Increased intramyocellular lipid droplets (HP:0012240)2.28136417
50Combined immunodeficiency (HP:0005387)2.26239797
51Abnormality of T cell number (HP:0011839)2.25711992
52Reticulocytopenia (HP:0001896)2.24014107
53Medial flaring of the eyebrow (HP:0010747)2.23873174
54Abnormality of alanine metabolism (HP:0010916)2.22645427
55Hyperalaninemia (HP:0003348)2.22645427
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22645427
57Abnormality of cells of the erythroid lineage (HP:0012130)2.20403634
58Increased corneal curvature (HP:0100692)2.20104974
59Keratoconus (HP:0000563)2.20104974
60Decreased electroretinogram (ERG) amplitude (HP:0000654)2.19828469
61Exertional dyspnea (HP:0002875)2.19418367
62Abnormality of T cells (HP:0002843)2.18927253
63Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18836831
64Polydipsia (HP:0001959)2.14355907
65Abnormal drinking behavior (HP:0030082)2.14355907
66Methylmalonic acidemia (HP:0002912)2.10809748
67Lactic acidosis (HP:0003128)2.04921028
68Tubular atrophy (HP:0000092)2.01167922
69Colon cancer (HP:0003003)1.95215546
70Renal cortical cysts (HP:0000803)1.95039439
71Chronic diarrhea (HP:0002028)1.94673297
72Abnormal respiratory motile cilium morphology (HP:0005938)1.93181562
73Abnormal respiratory epithelium morphology (HP:0012253)1.93181562
74Polyuria (HP:0000103)1.92790394
75Cystic liver disease (HP:0006706)1.90652224
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89425309
77Absent thumb (HP:0009777)1.88904775
78Increased muscle lipid content (HP:0009058)1.88075355
79Muscle fiber atrophy (HP:0100295)1.86352522
80Methylmalonic aciduria (HP:0012120)1.86020711
81Aplastic anemia (HP:0001915)1.85801035
82Abnormality of eosinophils (HP:0001879)1.84634491
83Sclerocornea (HP:0000647)1.84494415
84Abnormal number of erythroid precursors (HP:0012131)1.82280414
85Abnormality of T cell physiology (HP:0011840)1.81959346
86Lethargy (HP:0001254)1.81290505
87Constricted visual fields (HP:0001133)1.80142076
88Abnormal biliary tract physiology (HP:0012439)1.78764324
89Bile duct proliferation (HP:0001408)1.78764324
90Decreased circulating renin level (HP:0003351)1.78273867
91Respiratory failure (HP:0002878)1.77195178
92Aplasia/Hypoplasia of the spleen (HP:0010451)1.76835391
93Eosinophilia (HP:0001880)1.75665139
94Hypoplasia of the thymus (HP:0000778)1.73395583
95Congenital hepatic fibrosis (HP:0002612)1.72477530
96Chronic hepatic failure (HP:0100626)1.70619244
97Abnormality of renal resorption (HP:0011038)1.69133324
98Myositis (HP:0100614)1.67925787
99Asplenia (HP:0001746)1.67691366
100Abnormal ciliary motility (HP:0012262)1.67505187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.53162133
2TXK3.39281123
3TAOK33.21757265
4TIE13.00050025
5ZAK2.95330592
6EIF2AK32.89985795
7ADRBK22.71129496
8NUAK12.70296832
9GRK12.61529331
10TLK12.54543871
11TEC2.36721739
12MAP4K22.33818237
13WNK41.95163017
14EIF2AK11.78052185
15ITK1.77107507
16BCKDK1.74127813
17VRK21.61679210
18CDK191.56332844
19KIT1.54326763
20FES1.51559643
21BMPR1B1.46738545
22PINK11.37239716
23KDR1.36018317
24BTK1.35737931
25MAP3K121.33662196
26MAP4K11.30134153
27STK391.24649690
28OXSR11.21386477
29BMPR21.20303603
30MAPK131.18331718
31IKBKB1.15439975
32STK161.13633335
33MAPKAPK31.13003668
34SYK1.11677556
35WNK31.10118498
36MUSK1.03519964
37VRK10.95617620
38MKNK20.95187638
39CSNK1G30.90531233
40RPS6KA50.88464637
41EIF2AK20.84797442
42INSRR0.83688633
43PLK40.83661588
44PRKCQ0.82793079
45LCK0.81409890
46LYN0.79912786
47PHKG20.78918810
48PHKG10.78918810
49CSNK1G20.78004744
50MKNK10.76383944
51MST40.75999965
52BCR0.72265644
53CSNK1G10.71948713
54PLK30.68834004
55PASK0.68593681
56ADRBK10.67284442
57CSF1R0.66908427
58MAPKAPK50.62827561
59MAP2K60.62645235
60CSNK1A1L0.62093057
61FLT30.61225919
62GRK60.60557853
63MAP2K20.59504296
64IGF1R0.57698662
65PLK20.57632263
66DYRK20.57238712
67GRK70.55757517
68CAMK1D0.55638520
69OBSCN0.54371214
70IKBKE0.54133235
71NEK10.53980379
72ERBB30.53800751
73PIK3CA0.53444744
74DAPK20.52415033
75MAP3K40.52352020
76PRKCE0.52338469
77CDK80.51867736
78CHUK0.50117015
79LIMK10.49990747
80CAMKK20.49185426
81MYLK0.48347490
82ATR0.48135709
83ABL10.46443718
84TGFBR10.45855747
85CAMK10.45060188
86TSSK60.43481436
87NME10.43251267
88PDK20.42136053
89PRKACA0.41635039
90TRPM70.41169428
91PRKCA0.40732217
92PRKCG0.40592182
93JAK30.37346624
94CSNK2A10.36599011
95CSNK2A20.35925364
96PIK3CG0.35836424
97SRPK10.35260243
98DAPK10.34209568
99GRK50.34184798
100TRIM280.33735375

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.78764047
2Ribosome_Homo sapiens_hsa030103.09123537
3Proteasome_Homo sapiens_hsa030503.08953038
4Oxidative phosphorylation_Homo sapiens_hsa001903.01963060
5Intestinal immune network for IgA production_Homo sapiens_hsa046723.01073911
6Allograft rejection_Homo sapiens_hsa053302.96827843
7Autoimmune thyroid disease_Homo sapiens_hsa053202.84160426
8Primary immunodeficiency_Homo sapiens_hsa053402.59218549
9Graft-versus-host disease_Homo sapiens_hsa053322.58094197
10Parkinsons disease_Homo sapiens_hsa050122.54616317
11Protein export_Homo sapiens_hsa030602.50199716
12Caffeine metabolism_Homo sapiens_hsa002322.41577486
13Type I diabetes mellitus_Homo sapiens_hsa049402.37083825
14Linoleic acid metabolism_Homo sapiens_hsa005911.85526409
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83424580
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.81551655
17Homologous recombination_Homo sapiens_hsa034401.71635666
18Antigen processing and presentation_Homo sapiens_hsa046121.70650149
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69270069
20RNA polymerase_Homo sapiens_hsa030201.63978681
21Phototransduction_Homo sapiens_hsa047441.58749597
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.58434401
23Alzheimers disease_Homo sapiens_hsa050101.58433388
24Huntingtons disease_Homo sapiens_hsa050161.57803706
25Rheumatoid arthritis_Homo sapiens_hsa053231.55816325
26RNA degradation_Homo sapiens_hsa030181.51499743
27Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49772395
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47074440
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45853891
30Basal transcription factors_Homo sapiens_hsa030221.37098428
31Cardiac muscle contraction_Homo sapiens_hsa042601.35115885
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.33005618
33Hematopoietic cell lineage_Homo sapiens_hsa046401.21745247
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21211067
35One carbon pool by folate_Homo sapiens_hsa006701.13405429
36Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09330055
37Fanconi anemia pathway_Homo sapiens_hsa034601.08927219
38Propanoate metabolism_Homo sapiens_hsa006401.08224302
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06931532
40Nitrogen metabolism_Homo sapiens_hsa009101.03619066
41Ether lipid metabolism_Homo sapiens_hsa005651.02495419
42Tryptophan metabolism_Homo sapiens_hsa003801.00602595
43Staphylococcus aureus infection_Homo sapiens_hsa051500.99641647
44Viral myocarditis_Homo sapiens_hsa054160.97932898
45Nucleotide excision repair_Homo sapiens_hsa034200.97539044
46Butanoate metabolism_Homo sapiens_hsa006500.89579120
47Olfactory transduction_Homo sapiens_hsa047400.86434384
48Non-homologous end-joining_Homo sapiens_hsa034500.84651186
49Arachidonic acid metabolism_Homo sapiens_hsa005900.84258934
50Peroxisome_Homo sapiens_hsa041460.84114583
51Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82003424
52Chemical carcinogenesis_Homo sapiens_hsa052040.80247177
53Sulfur metabolism_Homo sapiens_hsa009200.78712597
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77824030
55Mismatch repair_Homo sapiens_hsa034300.76139001
56Purine metabolism_Homo sapiens_hsa002300.75937783
57Primary bile acid biosynthesis_Homo sapiens_hsa001200.73306547
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71636943
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71172070
60Regulation of autophagy_Homo sapiens_hsa041400.68628182
61Pyrimidine metabolism_Homo sapiens_hsa002400.67787036
62Retinol metabolism_Homo sapiens_hsa008300.65544424
63Systemic lupus erythematosus_Homo sapiens_hsa053220.65344803
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63105580
65RNA transport_Homo sapiens_hsa030130.62527444
66Drug metabolism - other enzymes_Homo sapiens_hsa009830.62314559
67Spliceosome_Homo sapiens_hsa030400.59049591
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.57945858
69Fat digestion and absorption_Homo sapiens_hsa049750.57174750
70Collecting duct acid secretion_Homo sapiens_hsa049660.57100439
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54475901
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53751914
73Cysteine and methionine metabolism_Homo sapiens_hsa002700.52956486
74Base excision repair_Homo sapiens_hsa034100.51329013
75Leishmaniasis_Homo sapiens_hsa051400.50301926
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.49911545
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48466721
78Metabolic pathways_Homo sapiens_hsa011000.47270569
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46107916
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44639121
81NF-kappa B signaling pathway_Homo sapiens_hsa040640.42729248
82Morphine addiction_Homo sapiens_hsa050320.42519957
83Selenocompound metabolism_Homo sapiens_hsa004500.42233102
84Herpes simplex infection_Homo sapiens_hsa051680.39135977
85Taste transduction_Homo sapiens_hsa047420.38993526
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32219965
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31633887
88Ovarian steroidogenesis_Homo sapiens_hsa049130.30566330
89T cell receptor signaling pathway_Homo sapiens_hsa046600.30537507
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.30297004
91Maturity onset diabetes of the young_Homo sapiens_hsa049500.30133473
92Jak-STAT signaling pathway_Homo sapiens_hsa046300.29311708
93Fatty acid biosynthesis_Homo sapiens_hsa000610.29137072
94Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.25932884
95beta-Alanine metabolism_Homo sapiens_hsa004100.25497588
96Nicotine addiction_Homo sapiens_hsa050330.25366224
97Serotonergic synapse_Homo sapiens_hsa047260.24849279
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.22595849
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.21505026
100Glycerolipid metabolism_Homo sapiens_hsa005610.20607175

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