ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	5.15008209
2	ribosomal large subunit biogenesis (GO:0042273)	4.84474275
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.78877861
4	ATP synthesis coupled proton transport (GO:0015986)	4.78877861
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.71355639
6	preassembly of GPI anchor in ER membrane (GO:0016254)	4.57958172
7	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	4.51167178
8	viral transcription (GO:0019083)	4.37212452
9	translational termination (GO:0006415)	4.31082052
10	DNA deamination (GO:0045006)	4.12477659
11	kynurenine metabolic process (GO:0070189)	3.96684191
12	maturation of SSU-rRNA (GO:0030490)	3.89576728
13	behavioral response to nicotine (GO:0035095)	3.85575225
14	negative regulation of heart rate (GO:0010459)	3.85319704
15	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.82537605
16	GPI anchor metabolic process (GO:0006505)	3.76729171
17	GPI anchor biosynthetic process (GO:0006506)	3.70396209
18	regulation of hypersensitivity (GO:0002883)	3.59498379
19	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.54133279
20	translational elongation (GO:0006414)	3.48504223
21	protein targeting to ER (GO:0045047)	3.47871056
22	positive regulation of mast cell activation involved in immune response (GO:0033008)	3.47645458
23	positive regulation of mast cell degranulation (GO:0043306)	3.47645458
24	cotranslational protein targeting to membrane (GO:0006613)	3.47086608
25	positive regulation of protein homodimerization activity (GO:0090073)	3.41891471
26	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.37134571
27	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.37134571
28	adaptation of signaling pathway (GO:0023058)	3.31972274
29	positive regulation of mast cell activation (GO:0033005)	3.30934011
30	protein localization to endoplasmic reticulum (GO:0070972)	3.30172450
31	cellular response to exogenous dsRNA (GO:0071360)	3.29627479
32	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.27914086
33	opioid receptor signaling pathway (GO:0038003)	3.26939417
34	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.25007926
35	regulation of cilium movement (GO:0003352)	3.22787085
36	regulation of feeding behavior (GO:0060259)	3.17243804
37	adult feeding behavior (GO:0008343)	3.15359820
38	viral life cycle (GO:0019058)	3.12108045
39	piRNA metabolic process (GO:0034587)	3.11143224
40	maturation of 5.8S rRNA (GO:0000460)	3.09155226
41	platelet dense granule organization (GO:0060155)	3.08718457
42	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.04438969
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.04067913
44	regulation of mitotic spindle checkpoint (GO:1903504)	3.03585892
45	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	3.03585892
46	electron transport chain (GO:0022900)	2.99924120
47	rRNA catabolic process (GO:0016075)	2.97532435
48	respiratory electron transport chain (GO:0022904)	2.97204800
49	indole-containing compound catabolic process (GO:0042436)	2.95753057
50	indolalkylamine catabolic process (GO:0046218)	2.95753057
51	tryptophan catabolic process (GO:0006569)	2.95753057
52	pyrimidine dimer repair (GO:0006290)	2.95459949
53	cytidine deamination (GO:0009972)	2.94285529
54	cytidine metabolic process (GO:0046087)	2.94285529
55	cytidine catabolic process (GO:0006216)	2.94285529
56	cellular protein complex disassembly (GO:0043624)	2.91408338
57	mannosylation (GO:0097502)	2.89483509
58	NAD biosynthetic process (GO:0009435)	2.89251442
59	ribosomal small subunit biogenesis (GO:0042274)	2.88569771
60	protein polyglutamylation (GO:0018095)	2.87203148
61	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.84160066
62	fucose catabolic process (GO:0019317)	2.84085935
63	L-fucose metabolic process (GO:0042354)	2.84085935
64	L-fucose catabolic process (GO:0042355)	2.84085935
65	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.82647582
66	detection of light stimulus involved in sensory perception (GO:0050962)	2.81354103
67	detection of light stimulus involved in visual perception (GO:0050908)	2.81354103
68	regulation of germinal center formation (GO:0002634)	2.80536731
69	nicotinamide nucleotide biosynthetic process (GO:0019359)	2.76833918
70	pyridine nucleotide biosynthetic process (GO:0019363)	2.76833918
71	nonmotile primary cilium assembly (GO:0035058)	2.72222271
72	translational initiation (GO:0006413)	2.71614209
73	indolalkylamine metabolic process (GO:0006586)	2.70858905
74	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	2.70741986
75	GMP metabolic process (GO:0046037)	2.70675603
76	positive regulation of histone H3-K4 methylation (GO:0051571)	2.69738584
77	response to interferon-beta (GO:0035456)	2.69381701
78	sleep (GO:0030431)	2.68734403
79	purine-containing compound salvage (GO:0043101)	2.68387977
80	purine nucleotide salvage (GO:0032261)	2.66474366
81	mast cell activation (GO:0045576)	2.64719686
82	tryptophan metabolic process (GO:0006568)	2.61239711
83	immunoglobulin mediated immune response (GO:0016064)	2.59918216
84	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.58551540
85	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.58402280
86	mature B cell differentiation (GO:0002335)	2.58370181
87	regulation of action potential (GO:0098900)	2.58301782
88	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.57488544
89	C-terminal protein lipidation (GO:0006501)	2.57107461
90	water-soluble vitamin biosynthetic process (GO:0042364)	2.55902196
91	negative regulation of telomere maintenance (GO:0032205)	2.53678203
92	neural tube formation (GO:0001841)	2.53072279
93	positive regulation of defense response to virus by host (GO:0002230)	2.52363920
94	S-adenosylmethionine metabolic process (GO:0046500)	2.51613604
95	endoderm formation (GO:0001706)	2.51582071
96	activated T cell proliferation (GO:0050798)	2.51287230
97	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.48793946
98	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.48793946
99	NADH dehydrogenase complex assembly (GO:0010257)	2.48793946
100	monoamine transport (GO:0015844)	2.48478169

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.78846023
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.79107225
3	EZH2_22144423_ChIP-Seq_EOC_Human	3.74069902
4	VDR_22108803_ChIP-Seq_LS180_Human	3.50241956
5	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.25005621
6	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.76945659
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.74035235
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.61910633
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.54780494
10	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.35605799
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.27022212
12	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.11328350
13	ER_23166858_ChIP-Seq_MCF-7_Human	2.08512733
14	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.03086001
15	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.94996142
16	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.88675004
17	VDR_23849224_ChIP-Seq_CD4+_Human	1.83991990
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.82407359
19	EWS_26573619_Chip-Seq_HEK293_Human	1.79916529
20	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.74377585
21	FUS_26573619_Chip-Seq_HEK293_Human	1.73003939
22	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.72529520
23	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.72167800
24	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.68538150
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.66905185
26	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.59360373
27	CBP_20019798_ChIP-Seq_JUKART_Human	1.57412905
28	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.57412905
29	P300_19829295_ChIP-Seq_ESCs_Human	1.56215808
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.55816837
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.55642559
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.51984793
33	GATA3_26560356_Chip-Seq_TH2_Human	1.50357262
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.50031828
35	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.49724912
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.45384929
37	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.45384929
38	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41771010
39	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.40063739
40	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.39950316
41	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.38517284
42	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.37859156
43	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34283339
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.34280596
45	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.33202642
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30722823
47	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.30400867
48	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.29028019
49	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.25923353
50	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.24555208
51	SOX2_19829295_ChIP-Seq_ESCs_Human	1.21779152
52	NANOG_19829295_ChIP-Seq_ESCs_Human	1.21779152
53	MYC_18940864_ChIP-ChIP_HL60_Human	1.21280510
54	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.19610002
55	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.19520209
56	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.19520209
57	RNF2_27304074_Chip-Seq_NSC_Mouse	1.17067782
58	AR_20517297_ChIP-Seq_VCAP_Human	1.16694642
59	ERG_20517297_ChIP-Seq_VCAP_Human	1.15900881
60	GATA3_26560356_Chip-Seq_TH1_Human	1.15734512
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.15452733
62	BCAT_22108803_ChIP-Seq_LS180_Human	1.13621114
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11042999
64	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.09943764
65	MYB_26560356_Chip-Seq_TH2_Human	1.09555381
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08894776
67	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.08775743
68	TCF4_22108803_ChIP-Seq_LS180_Human	1.08370566
69	STAT1_20625510_ChIP-Seq_HELA_Human	1.07867972
70	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.07410804
71	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05781386
72	TCF4_23295773_ChIP-Seq_U87_Human	1.05312370
73	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01218228
74	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01214353
75	RUNX_20019798_ChIP-Seq_JUKART_Human	1.00316397
76	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.99862225
77	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99648938
78	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.98643287
79	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.98381789
80	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.97790461
81	IRF1_19129219_ChIP-ChIP_H3396_Human	0.97130310
82	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.96180382
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96170881
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	0.96063450
85	SMAD4_21799915_ChIP-Seq_A2780_Human	0.95863913
86	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.95708027
87	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.95464101
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.95066098
89	AR_25329375_ChIP-Seq_VCAP_Human	0.94838246
90	TAF2_19829295_ChIP-Seq_ESCs_Human	0.94381574
91	SALL4_22934838_ChIP-ChIP_CD34+_Human	0.94209353
92	CDX2_22108803_ChIP-Seq_LS180_Human	0.93841773
93	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.92942694
94	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92935830
95	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.92591904
96	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	0.92491643
97	NCOR_22424771_ChIP-Seq_293T_Human	0.92232507
98	STAT3_23295773_ChIP-Seq_U87_Human	0.91935313
99	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91086110
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.88742458

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	4.45443039
2	MP0003787_abnormal_imprinting	3.14554609
3	MP0006292_abnormal_olfactory_placode	3.04753270
4	MP0001835_abnormal_antigen_presentation	3.04171374
5	MP0003724_increased_susceptibility_to	2.95041322
6	MP0005671_abnormal_response_to	2.84880727
7	MP0002102_abnormal_ear_morphology	2.77301502
8	MP0002138_abnormal_hepatobiliary_system	2.58257110
9	MP0001968_abnormal_touch/_nociception	2.38943435
10	MP0005084_abnormal_gallbladder_morpholo	2.30043239
11	MP0006072_abnormal_retinal_apoptosis	2.22124624
12	MP0002837_dystrophic_cardiac_calcinosis	2.09433417
13	MP0009379_abnormal_foot_pigmentation	2.04072738
14	MP0003806_abnormal_nucleotide_metabolis	1.93795654
15	MP0003950_abnormal_plasma_membrane	1.90908325
16	MP0008872_abnormal_physiological_respon	1.89736339
17	MP0004142_abnormal_muscle_tone	1.88072910
18	MP0001800_abnormal_humoral_immune	1.83751487
19	MP0005551_abnormal_eye_electrophysiolog	1.80854544
20	MP0008057_abnormal_DNA_replication	1.78528251
21	MP0002736_abnormal_nociception_after	1.78080308
22	MP0008789_abnormal_olfactory_epithelium	1.71291664
23	MP0005646_abnormal_pituitary_gland	1.71069579
24	MP0001661_extended_life_span	1.69728765
25	MP0000372_irregular_coat_pigmentation	1.69400181
26	MP0008995_early_reproductive_senescence	1.67355319
27	MP0001986_abnormal_taste_sensitivity	1.66831825
28	MP0003436_decreased_susceptibility_to	1.64383748
29	MP0003880_abnormal_central_pattern	1.58372650
30	MP0005000_abnormal_immune_tolerance	1.54469947
31	MP0003646_muscle_fatigue	1.53060509
32	MP0005253_abnormal_eye_physiology	1.52858567
33	MP0009764_decreased_sensitivity_to	1.52606531
34	MP0002148_abnormal_hypersensitivity_rea	1.51073918
35	MP0003786_premature_aging	1.44901013
36	MP0008875_abnormal_xenobiotic_pharmacok	1.41595819
37	MP0009333_abnormal_splenocyte_physiolog	1.35777725
38	MP0002876_abnormal_thyroid_physiology	1.33366292
39	MP0002090_abnormal_vision	1.30707729
40	MP0000569_abnormal_digit_pigmentation	1.29967901
41	MP0006035_abnormal_mitochondrial_morpho	1.29161881
42	MP0004145_abnormal_muscle_electrophysio	1.28411990
43	MP0001970_abnormal_pain_threshold	1.24062105
44	MP0002452_abnormal_antigen_presenting	1.20490821
45	MP0002723_abnormal_immune_serum	1.19566318
46	MP0002234_abnormal_pharynx_morphology	1.17520551
47	MP0001873_stomach_inflammation	1.16905970
48	MP0000516_abnormal_urinary_system	1.14742627
49	MP0005367_renal/urinary_system_phenotyp	1.14742627
50	MP0005645_abnormal_hypothalamus_physiol	1.12929206
51	MP0001919_abnormal_reproductive_system	1.12745468
52	MP0000427_abnormal_hair_cycle	1.12057137
53	MP0005499_abnormal_olfactory_system	1.08706179
54	MP0005394_taste/olfaction_phenotype	1.08706179
55	MP0004147_increased_porphyrin_level	1.08593360
56	MP0000383_abnormal_hair_follicle	1.07394960
57	MP0004782_abnormal_surfactant_physiolog	1.07075752
58	MP0008058_abnormal_DNA_repair	1.06373467
59	MP0005085_abnormal_gallbladder_physiolo	1.05920483
60	MP0001819_abnormal_immune_cell	1.05565492
61	MP0002254_reproductive_system_inflammat	1.04595499
62	MP0002420_abnormal_adaptive_immunity	1.03655915
63	MP0002733_abnormal_thermal_nociception	1.03077047
64	MP0005389_reproductive_system_phenotype	1.01686413
65	MP0005167_abnormal_blood-brain_barrier	1.01232824
66	MP0002166_altered_tumor_susceptibility	0.99503140
67	MP0010155_abnormal_intestine_physiology	0.99493657
68	MP0008775_abnormal_heart_ventricle	0.98490141
69	MP0003866_abnormal_defecation	0.96754998
70	MP0003186_abnormal_redox_activity	0.95826061
71	MP0009785_altered_susceptibility_to	0.95306059
72	MP0002928_abnormal_bile_duct	0.93504419
73	MP0001486_abnormal_startle_reflex	0.88469003
74	MP0006276_abnormal_autonomic_nervous	0.88350020
75	MP0000685_abnormal_immune_system	0.87178375
76	MP0000013_abnormal_adipose_tissue	0.85961601
77	MP0001765_abnormal_ion_homeostasis	0.85775458
78	MP0002272_abnormal_nervous_system	0.85069870
79	MP0001533_abnormal_skeleton_physiology	0.84455212
80	MP0006054_spinal_hemorrhage	0.83256305
81	MP0000230_abnormal_systemic_arterial	0.80449617
82	MP0001293_anophthalmia	0.80016880
83	MP0005195_abnormal_posterior_eye	0.79969641
84	MP0003763_abnormal_thymus_physiology	0.79587523
85	MP0010386_abnormal_urinary_bladder	0.78872893
86	MP0006036_abnormal_mitochondrial_physio	0.76607264
87	MP0009046_muscle_twitch	0.74752936
88	MP0003195_calcinosis	0.74631048
89	MP0005647_abnormal_sex_gland	0.74306700
90	MP0008007_abnormal_cellular_replicative	0.74229950
91	MP0009765_abnormal_xenobiotic_induced	0.74186880
92	MP0005670_abnormal_white_adipose	0.73569112
93	MP0002419_abnormal_innate_immunity	0.70549433
94	MP0000716_abnormal_immune_system	0.70518029
95	MP0003828_pulmonary_edema	0.69523822
96	MP0003136_yellow_coat_color	0.69072459
97	MP0002398_abnormal_bone_marrow	0.68842372
98	MP0001845_abnormal_inflammatory_respons	0.68308082
99	MP0009745_abnormal_behavioral_response	0.67645978
100	MP0002751_abnormal_autonomic_nervous	0.67369033

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	3.91397522
2	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.74860324
3	Testicular atrophy (HP:0000029)	3.69686017
4	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	3.62081764
5	Abnormality of the prostate (HP:0008775)	3.60009872
6	Visual hallucinations (HP:0002367)	3.53180932
7	Prostate neoplasm (HP:0100787)	3.52137841
8	Autoimmune hemolytic anemia (HP:0001890)	3.28936791
9	Pancreatic fibrosis (HP:0100732)	3.17330242
10	IgG deficiency (HP:0004315)	3.06465198
11	Acute necrotizing encephalopathy (HP:0006965)	3.04616141
12	Supernumerary spleens (HP:0009799)	3.02843804
13	Abnormality of midbrain morphology (HP:0002418)	3.02668039
14	Molar tooth sign on MRI (HP:0002419)	3.02668039
15	Abnormality of B cell number (HP:0010975)	3.00047103
16	Pancreatic cysts (HP:0001737)	2.92381978
17	Increased cerebral lipofuscin (HP:0011813)	2.92208955
18	Asplenia (HP:0001746)	2.91870629
19	Autoimmune thrombocytopenia (HP:0001973)	2.91123250
20	Congenital stationary night blindness (HP:0007642)	2.90956278
21	B lymphocytopenia (HP:0010976)	2.88181219
22	Absent/shortened dynein arms (HP:0200106)	2.87115020
23	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.87115020
24	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.84037937
25	Large eyes (HP:0001090)	2.82623146
26	Abnormal mitochondria in muscle tissue (HP:0008316)	2.80083743
27	Abolished electroretinogram (ERG) (HP:0000550)	2.78407796
28	Mitochondrial inheritance (HP:0001427)	2.73212338
29	Increased CSF lactate (HP:0002490)	2.69513305
30	Alveolar cell carcinoma (HP:0006519)	2.67543400
31	Decreased central vision (HP:0007663)	2.66457297
32	Abnormal rod and cone electroretinograms (HP:0008323)	2.65147493
33	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.64844622
34	Attenuation of retinal blood vessels (HP:0007843)	2.59765586
35	Keratoconus (HP:0000563)	2.59532601
36	Increased corneal curvature (HP:0100692)	2.59532601
37	Progressive macrocephaly (HP:0004481)	2.56985335
38	Stomatitis (HP:0010280)	2.56701645
39	Reticulocytopenia (HP:0001896)	2.54644578
40	Lipid accumulation in hepatocytes (HP:0006561)	2.51205356
41	Nephronophthisis (HP:0000090)	2.49851987
42	Increased hepatocellular lipid droplets (HP:0006565)	2.49375219
43	Macrocytic anemia (HP:0001972)	2.48188334
44	Acute encephalopathy (HP:0006846)	2.46845390
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.41569888
46	Neoplasm of the tracheobronchial system (HP:0100552)	2.40358871
47	Abnormality of the renal cortex (HP:0011035)	2.39251164
48	Abnormality of the renal medulla (HP:0100957)	2.38156878
49	Central scotoma (HP:0000603)	2.38040000
50	Elevated erythrocyte sedimentation rate (HP:0003565)	2.31790968
51	Abnormal drinking behavior (HP:0030082)	2.21734830
52	Polydipsia (HP:0001959)	2.21734830
53	Dry hair (HP:0011359)	2.21536830
54	Inability to walk (HP:0002540)	2.17625952
55	Azoospermia (HP:0000027)	2.16844656
56	Optic disc pallor (HP:0000543)	2.16740937
57	Abnormal number of erythroid precursors (HP:0012131)	2.15429675
58	Bile duct proliferation (HP:0001408)	2.12215919
59	Abnormal biliary tract physiology (HP:0012439)	2.12215919
60	Cerebral edema (HP:0002181)	2.11379846
61	Methylmalonic acidemia (HP:0002912)	2.10833464
62	True hermaphroditism (HP:0010459)	2.07917659
63	Bilateral microphthalmos (HP:0007633)	2.07260935
64	Abnormal spermatogenesis (HP:0008669)	2.07156296
65	Renal cortical cysts (HP:0000803)	2.07122166
66	Abnormal hemoglobin (HP:0011902)	2.03782099
67	Abnormality of male internal genitalia (HP:0000022)	2.03700794
68	Thrombocytosis (HP:0001894)	2.02979691
69	Hepatocellular necrosis (HP:0001404)	2.00229766
70	Reduced antithrombin III activity (HP:0001976)	1.99309176
71	Congenital hepatic fibrosis (HP:0002612)	1.94320585
72	Tubular atrophy (HP:0000092)	1.92989625
73	Scotoma (HP:0000575)	1.91009549
74	Focal motor seizures (HP:0011153)	1.90851474
75	Abnormal respiratory motile cilium morphology (HP:0005938)	1.88509820
76	Abnormal respiratory epithelium morphology (HP:0012253)	1.88509820
77	Hypochromic microcytic anemia (HP:0004840)	1.88339655
78	Pallor (HP:0000980)	1.87420808
79	Medial flaring of the eyebrow (HP:0010747)	1.87250087
80	Increased serum lactate (HP:0002151)	1.86175627
81	Cystic liver disease (HP:0006706)	1.86171975
82	Chronic hepatic failure (HP:0100626)	1.86054096
83	Type II lissencephaly (HP:0007260)	1.85450404
84	Abnormal ciliary motility (HP:0012262)	1.85350830
85	Increased intramyocellular lipid droplets (HP:0012240)	1.84767773
86	Hypoproteinemia (HP:0003075)	1.84384271
87	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.83201737
88	Exertional dyspnea (HP:0002875)	1.82498354
89	Stomach cancer (HP:0012126)	1.81732011
90	Abnormality of secondary sexual hair (HP:0009888)	1.80624258
91	Abnormality of the axillary hair (HP:0100134)	1.80624258
92	Decreased activity of mitochondrial respiratory chain (HP:0008972)	1.80471353
93	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	1.80471353
94	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.79735767
95	Tachypnea (HP:0002789)	1.77660612
96	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.74109635
97	Fair hair (HP:0002286)	1.73949547
98	Spontaneous abortion (HP:0005268)	1.71863844
99	Concave nail (HP:0001598)	1.71211742
100	Dyschromatopsia (HP:0007641)	1.70209898

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TAOK3	3.89354833
2	BMPR2	3.79179097
3	SCYL2	3.51202721
4	TXK	2.96311890
5	FRK	2.80216007
6	MAP4K1	2.77908412
7	CDK19	2.72149977
8	TLK1	2.55323104
9	ADRBK2	2.51057000
10	TIE1	2.38274327
11	TRPM7	2.38198746
12	GRK1	2.36266619
13	PLK4	2.30196708
14	DAPK2	2.29364175
15	WNK4	2.10949256
16	BMPR1B	1.90960538
17	OXSR1	1.89082903
18	CDK8	1.88550341
19	TEC	1.77631149
20	GRK6	1.69326787
21	IKBKB	1.68798950
22	NUAK1	1.63667558
23	BCKDK	1.49541641
24	ZAK	1.44991599
25	MAP3K12	1.42341205
26	PNCK	1.39056170
27	MAP2K2	1.37639093
28	WNK1	1.35357123
29	BTK	1.21721619
30	STK39	1.20375333
31	ITK	1.15731942
32	SYK	1.15217660
33	FES	1.14947032
34	PINK1	1.07417406
35	PIK3CA	1.05505695
36	IKBKE	1.01793377
37	MYLK	1.01013244
38	RPS6KB2	1.01000481
39	ERBB3	1.00916468
40	PLK2	0.98859575
41	MAP3K14	0.96612980
42	CAMKK2	0.95109665
43	TBK1	0.92841782
44	MST4	0.87435191
45	WNK3	0.85561704
46	ADRBK1	0.70528088
47	CHUK	0.70378845
48	PHKG2	0.69163253
49	PHKG1	0.69163253
50	OBSCN	0.67148372
51	INSRR	0.66243390
52	KIT	0.63814658
53	PIM1	0.62258188
54	STK16	0.61627761
55	STK4	0.60176473
56	LYN	0.57956173
57	DAPK1	0.57661599
58	TRIM28	0.55943094
59	PRKCE	0.55824700
60	CAMKK1	0.54019252
61	ALK	0.52235202
62	ZAP70	0.50567468
63	IGF1R	0.50127036
64	MAPK13	0.49936954
65	DAPK3	0.49657652
66	MAP2K1	0.49396865
67	ABL1	0.49286292
68	HCK	0.47332393
69	CSF1R	0.46953063
70	LCK	0.45995435
71	JAK3	0.45365086
72	PIK3CG	0.45103057
73	EIF2AK3	0.44923771
74	CHEK2	0.43329602
75	PRKACA	0.42544733
76	PASK	0.41966557
77	PRKCG	0.41573531
78	ILK	0.41442585
79	TGFBR1	0.40855253
80	CAMK2D	0.39777862
81	PTK2B	0.39204032
82	EIF2AK2	0.39137987
83	TNIK	0.38100510
84	PRKCQ	0.37427451
85	CDC7	0.36800261
86	FLT3	0.36650128
87	CSNK2A2	0.36575864
88	ATR	0.36367722
89	MATK	0.35611241
90	RPS6KA6	0.34601183
91	SGK1	0.33239070
92	RPS6KB1	0.32937380
93	PRKCA	0.31254299
94	MAP2K6	0.31157609
95	RPS6KA5	0.29392665
96	CSNK1G2	0.29225248
97	MAP4K2	0.28100131
98	CSNK2A1	0.27647638
99	CAMK2A	0.26577831
100	NEK1	0.26560775

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.31892395
2	Intestinal immune network for IgA production_Homo sapiens_hsa04672	4.06357421
3	Allograft rejection_Homo sapiens_hsa05330	3.87920762
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.63621355
5	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.48843461
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.17396222
7	Ribosome_Homo sapiens_hsa03010	3.02488587
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.87816460
9	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59410599
10	Parkinsons disease_Homo sapiens_hsa05012	2.20933277
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.94317704
12	Homologous recombination_Homo sapiens_hsa03440	1.93825662
13	Rheumatoid arthritis_Homo sapiens_hsa05323	1.88293842
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.76470302
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.75073748
16	Viral myocarditis_Homo sapiens_hsa05416	1.73882972
17	Leishmaniasis_Homo sapiens_hsa05140	1.70513482
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66784609
19	Proteasome_Homo sapiens_hsa03050	1.64242127
20	One carbon pool by folate_Homo sapiens_hsa00670	1.63742950
21	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.56997631
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.56934120
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.55052343
24	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.48625663
25	Alzheimers disease_Homo sapiens_hsa05010	1.44778005
26	Huntingtons disease_Homo sapiens_hsa05016	1.31980863
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.30649890
28	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.29066414
29	Protein export_Homo sapiens_hsa03060	1.28100845
30	Phototransduction_Homo sapiens_hsa04744	1.18167464
31	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13588989
32	RNA degradation_Homo sapiens_hsa03018	1.11203978
33	Regulation of autophagy_Homo sapiens_hsa04140	0.99095115
34	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.97279117
35	Ether lipid metabolism_Homo sapiens_hsa00565	0.96155551
36	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.96143599
37	Chemical carcinogenesis_Homo sapiens_hsa05204	0.94926794
38	Olfactory transduction_Homo sapiens_hsa04740	0.93283070
39	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.83824221
40	Nucleotide excision repair_Homo sapiens_hsa03420	0.83137248
41	Taste transduction_Homo sapiens_hsa04742	0.82872920
42	Primary immunodeficiency_Homo sapiens_hsa05340	0.80148682
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.79500487
44	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.77388385
45	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.73400635
46	Caffeine metabolism_Homo sapiens_hsa00232	0.72716487
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.72436384
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.72099038
49	RNA polymerase_Homo sapiens_hsa03020	0.70990992
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69886113
51	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.69109444
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.67218958
53	Basal transcription factors_Homo sapiens_hsa03022	0.67157438
54	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.66457329
55	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.64641385
56	Toxoplasmosis_Homo sapiens_hsa05145	0.64333863
57	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.62498091
58	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.61986851
59	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.61470131
60	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.59492921
61	Tryptophan metabolism_Homo sapiens_hsa00380	0.58769620
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.58559501
63	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56134051
64	Nicotine addiction_Homo sapiens_hsa05033	0.55267400
65	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.53880210
66	Retinol metabolism_Homo sapiens_hsa00830	0.53132247
67	Tuberculosis_Homo sapiens_hsa05152	0.50899740
68	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50812790
69	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.49126538
70	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.48728368
71	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.47872804
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.44253296
73	Herpes simplex infection_Homo sapiens_hsa05168	0.42509614
74	Peroxisome_Homo sapiens_hsa04146	0.41533406
75	Serotonergic synapse_Homo sapiens_hsa04726	0.39748047
76	Propanoate metabolism_Homo sapiens_hsa00640	0.38441936
77	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.38391043
78	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.36615584
79	Purine metabolism_Homo sapiens_hsa00230	0.36514020
80	Metabolic pathways_Homo sapiens_hsa01100	0.34553465
81	Salivary secretion_Homo sapiens_hsa04970	0.26976696
82	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.26842860
83	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.26616392
84	Butanoate metabolism_Homo sapiens_hsa00650	0.25489280
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.23472157
86	RNA transport_Homo sapiens_hsa03013	0.23147138
87	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.22293962
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.21204994
89	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.20984026
90	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20572852
91	ABC transporters_Homo sapiens_hsa02010	0.20401881
92	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.19635071
93	Morphine addiction_Homo sapiens_hsa05032	0.19589703
94	African trypanosomiasis_Homo sapiens_hsa05143	0.19438846
95	Spliceosome_Homo sapiens_hsa03040	0.19326819
96	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.18934146
97	Influenza A_Homo sapiens_hsa05164	0.18912863
98	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.18627488
99	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.18472402
100	Non-homologous end-joining_Homo sapiens_hsa03450	0.18217736

RPL7P25

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »