RPL7P26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.27805016
2ATP synthesis coupled proton transport (GO:0015986)4.76714940
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.76714940
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.54126504
5ribosomal small subunit assembly (GO:0000028)4.24572108
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.11853667
7kynurenine metabolic process (GO:0070189)3.90286223
8tryptophan catabolic process (GO:0006569)3.81652710
9indole-containing compound catabolic process (GO:0042436)3.81652710
10indolalkylamine catabolic process (GO:0046218)3.81652710
11cytidine metabolic process (GO:0046087)3.76677564
12cytidine catabolic process (GO:0006216)3.76677564
13cytidine deamination (GO:0009972)3.76677564
14mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.73749524
15ribosomal large subunit biogenesis (GO:0042273)3.53987649
16establishment of protein localization to mitochondrial membrane (GO:0090151)3.47407833
17behavioral response to nicotine (GO:0035095)3.43423705
18negative regulation of mast cell activation (GO:0033004)3.42875122
19maturation of SSU-rRNA (GO:0030490)3.41318142
20respiratory electron transport chain (GO:0022904)3.40467267
21RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.39777176
22tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.39777176
23electron transport chain (GO:0022900)3.39564215
24viral transcription (GO:0019083)3.38750487
25pyrimidine ribonucleoside catabolic process (GO:0046133)3.35678282
26nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25380833
27protein complex biogenesis (GO:0070271)3.24719768
28mitochondrial respiratory chain complex I assembly (GO:0032981)3.24453921
29NADH dehydrogenase complex assembly (GO:0010257)3.24453921
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24453921
31tryptophan metabolic process (GO:0006568)3.23806525
32translational termination (GO:0006415)3.21630602
33rRNA modification (GO:0000154)3.20039038
34transcription elongation from RNA polymerase III promoter (GO:0006385)3.19381656
35termination of RNA polymerase III transcription (GO:0006386)3.19381656
36positive regulation of defense response to virus by host (GO:0002230)3.17680689
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16080828
38SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14923915
39preassembly of GPI anchor in ER membrane (GO:0016254)3.12774642
40positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.12723432
41protein neddylation (GO:0045116)3.10958557
42positive regulation of cell fate commitment (GO:0010455)3.09903895
43cotranslational protein targeting to membrane (GO:0006613)3.09480181
44protein targeting to ER (GO:0045047)3.09004026
45RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.06497493
46water-soluble vitamin biosynthetic process (GO:0042364)2.98224279
47piRNA metabolic process (GO:0034587)2.98007786
48cornea development in camera-type eye (GO:0061303)2.97645530
49regulation of cellular amino acid metabolic process (GO:0006521)2.95516232
50translational elongation (GO:0006414)2.95145103
51mitochondrial respiratory chain complex assembly (GO:0033108)2.94605990
52regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.93865628
53indolalkylamine metabolic process (GO:0006586)2.93847518
54protein localization to endoplasmic reticulum (GO:0070972)2.93830449
55L-fucose catabolic process (GO:0042355)2.92868843
56fucose catabolic process (GO:0019317)2.92868843
57L-fucose metabolic process (GO:0042354)2.92868843
58establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89780193
59negative regulation of T cell differentiation in thymus (GO:0033085)2.88628256
60chaperone-mediated protein transport (GO:0072321)2.88526042
61DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.88301019
62GTP biosynthetic process (GO:0006183)2.84911013
63regulation of isotype switching to IgG isotypes (GO:0048302)2.83183242
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.82047857
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.82047857
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.82047857
67negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80581170
68mast cell activation involved in immune response (GO:0002279)2.78998059
69mast cell degranulation (GO:0043303)2.78998059
70detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.78528779
71negative regulation of heart rate (GO:0010459)2.76901480
72signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.76730480
73intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.76730480
74regulation of immunoglobulin secretion (GO:0051023)2.74479710
75hydrogen ion transmembrane transport (GO:1902600)2.73647864
76GPI anchor metabolic process (GO:0006505)2.73212921
77amine catabolic process (GO:0009310)2.71347506
78cellular biogenic amine catabolic process (GO:0042402)2.71347506
79somite development (GO:0061053)2.70524713
80proton transport (GO:0015992)2.69701838
81translation (GO:0006412)2.68409026
82positive regulation of protein homodimerization activity (GO:0090073)2.67974692
83respiratory chain complex IV assembly (GO:0008535)2.67784642
84purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.67682784
85purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67194581
86mast cell activation (GO:0045576)2.66099643
87aldehyde catabolic process (GO:0046185)2.65681455
88hydrogen transport (GO:0006818)2.65622595
89positive regulation of prostaglandin secretion (GO:0032308)2.65364665
90sulfation (GO:0051923)2.64945354
91proteasome assembly (GO:0043248)2.64660955
92signal transduction involved in cell cycle checkpoint (GO:0072395)2.64519235
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.63887481
94signal transduction involved in DNA integrity checkpoint (GO:0072401)2.63887481
95ATP biosynthetic process (GO:0006754)2.62242291
96positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.58072357
97mannosylation (GO:0097502)2.56682664
98epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.56109305
99pseudouridine synthesis (GO:0001522)2.55698156
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.55010459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human3.64907418
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54188083
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.26058083
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.13063828
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.04854873
6VDR_22108803_ChIP-Seq_LS180_Human2.93900367
7ZNF274_21170338_ChIP-Seq_K562_Hela2.71468858
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.59048120
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46855216
10FLI1_27457419_Chip-Seq_LIVER_Mouse2.37481922
11VDR_23849224_ChIP-Seq_CD4+_Human2.27376887
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.17014194
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.14232473
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.13213414
15EZH2_22144423_ChIP-Seq_EOC_Human2.13094118
16ETS1_20019798_ChIP-Seq_JURKAT_Human2.03102142
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.00413370
18IGF1R_20145208_ChIP-Seq_DFB_Human1.93080017
19ELK1_19687146_ChIP-ChIP_HELA_Human1.92022025
20PCGF2_27294783_Chip-Seq_ESCs_Mouse1.86898766
21TAF15_26573619_Chip-Seq_HEK293_Human1.84092978
22EWS_26573619_Chip-Seq_HEK293_Human1.78674699
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.74142973
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.74024994
25FOXP3_21729870_ChIP-Seq_TREG_Human1.72514564
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71321074
27MYC_18940864_ChIP-ChIP_HL60_Human1.69964131
28TP53_22573176_ChIP-Seq_HFKS_Human1.64054600
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63674388
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.63481467
31IRF1_19129219_ChIP-ChIP_H3396_Human1.62736338
32PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61222597
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.56099933
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55898338
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.55254366
36FUS_26573619_Chip-Seq_HEK293_Human1.53270867
37GATA3_26560356_Chip-Seq_TH2_Human1.52301421
38FOXA1_27270436_Chip-Seq_PROSTATE_Human1.50186948
39FOXA1_25329375_ChIP-Seq_VCAP_Human1.50186948
40ER_23166858_ChIP-Seq_MCF-7_Human1.47647341
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45615789
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42563962
43IRF8_21731497_ChIP-ChIP_J774_Mouse1.40966345
44AR_20517297_ChIP-Seq_VCAP_Human1.39979652
45CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39756629
46MYC_18555785_ChIP-Seq_MESCs_Mouse1.39121668
47MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38989466
48GBX2_23144817_ChIP-Seq_PC3_Human1.38906255
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38734311
50P300_19829295_ChIP-Seq_ESCs_Human1.37250119
51SOX2_19829295_ChIP-Seq_ESCs_Human1.36355022
52NANOG_19829295_ChIP-Seq_ESCs_Human1.36355022
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32456544
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32410914
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.30505876
56GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.29409098
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.29317314
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.28615746
59TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28258733
60AUTS2_25519132_ChIP-Seq_293T-REX_Human1.27675488
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.26773407
62SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23742240
63TDRD3_21172665_ChIP-Seq_MCF-7_Human1.20865185
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20532101
65FOXH1_21741376_ChIP-Seq_EPCs_Human1.20340464
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19509014
67CBP_20019798_ChIP-Seq_JUKART_Human1.19509014
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18915027
69CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.17316834
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16353558
71ERG_20517297_ChIP-Seq_VCAP_Human1.15507413
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12286963
73PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12161306
74FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11573120
75TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.11419515
76PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.10304568
77HOXB7_26014856_ChIP-Seq_BT474_Human1.08113270
78EZH2_27294783_Chip-Seq_NPCs_Mouse1.06811490
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05522657
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.04966382
81NCOR_22424771_ChIP-Seq_293T_Human1.04608408
82NANOG_20526341_ChIP-Seq_ESCs_Human1.04388387
83FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99482267
84BCAT_22108803_ChIP-Seq_LS180_Human0.98827967
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98575119
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98556999
87TAF2_19829295_ChIP-Seq_ESCs_Human0.97027494
88EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97027380
89TTF2_22483619_ChIP-Seq_HELA_Human0.96963136
90PRDM14_20953172_ChIP-Seq_ESCs_Human0.96850801
91MYC_19829295_ChIP-Seq_ESCs_Human0.96160413
92CRX_20693478_ChIP-Seq_RETINA_Mouse0.95638743
93HTT_18923047_ChIP-ChIP_STHdh_Human0.95259600
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.92966276
95GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.92724938
96CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92640663
97HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92506343
98ELK1_22589737_ChIP-Seq_MCF10A_Human0.92150279
99ERA_21632823_ChIP-Seq_H3396_Human0.91197177
100KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90097173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.75785756
2MP0005671_abnormal_response_to3.08613244
3MP0001835_abnormal_antigen_presentation2.99884371
4MP0008877_abnormal_DNA_methylation2.93910087
5MP0008875_abnormal_xenobiotic_pharmacok2.40858804
6MP0002102_abnormal_ear_morphology2.32128292
7MP0003787_abnormal_imprinting2.24139329
8MP0008872_abnormal_physiological_respon2.18429175
9MP0002638_abnormal_pupillary_reflex2.12442556
10MP0006072_abnormal_retinal_apoptosis2.12386877
11MP0009379_abnormal_foot_pigmentation2.11621175
12MP0001986_abnormal_taste_sensitivity2.01874254
13MP0004147_increased_porphyrin_level1.93478113
14MP0008789_abnormal_olfactory_epithelium1.93460982
15MP0002138_abnormal_hepatobiliary_system1.90817258
16MP0005646_abnormal_pituitary_gland1.88614727
17MP0002234_abnormal_pharynx_morphology1.85910713
18MP0005645_abnormal_hypothalamus_physiol1.82971777
19MP0005084_abnormal_gallbladder_morpholo1.75933894
20MP0004145_abnormal_muscle_electrophysio1.73869662
21MP0003646_muscle_fatigue1.72413248
22MP0001968_abnormal_touch/_nociception1.71128469
23MP0004142_abnormal_muscle_tone1.66922736
24MP0005551_abnormal_eye_electrophysiolog1.57875748
25MP0001800_abnormal_humoral_immune1.56147677
26MP0002938_white_spotting1.54728620
27MP0004885_abnormal_endolymph1.52114696
28MP0002160_abnormal_reproductive_system1.50371344
29MP0000685_abnormal_immune_system1.45519828
30MP0005389_reproductive_system_phenotype1.45075511
31MP0003806_abnormal_nucleotide_metabolis1.45013195
32MP0002166_altered_tumor_susceptibility1.44961402
33MP0002148_abnormal_hypersensitivity_rea1.44199663
34MP0002837_dystrophic_cardiac_calcinosis1.43761527
35MP0002006_tumorigenesis1.37217928
36MP0009785_altered_susceptibility_to1.35428467
37MP0003195_calcinosis1.31913850
38MP0000372_irregular_coat_pigmentation1.30124035
39MP0002736_abnormal_nociception_after1.29485455
40MP0001501_abnormal_sleep_pattern1.28978982
41MP0002272_abnormal_nervous_system1.28170356
42MP0005499_abnormal_olfactory_system1.27711839
43MP0005394_taste/olfaction_phenotype1.27711839
44MP0001485_abnormal_pinna_reflex1.24710654
45MP0001919_abnormal_reproductive_system1.24417272
46MP0005075_abnormal_melanosome_morpholog1.23085406
47MP0005387_immune_system_phenotype1.22647449
48MP0001790_abnormal_immune_system1.22647449
49MP0002876_abnormal_thyroid_physiology1.22438841
50MP0005000_abnormal_immune_tolerance1.20696808
51MP0008995_early_reproductive_senescence1.20417663
52MP0003011_delayed_dark_adaptation1.18908195
53MP0003724_increased_susceptibility_to1.18784943
54MP0005377_hearing/vestibular/ear_phenot1.18032903
55MP0003878_abnormal_ear_physiology1.18032903
56MP0003786_premature_aging1.17069516
57MP0002733_abnormal_thermal_nociception1.16590106
58MP0002723_abnormal_immune_serum1.15899427
59MP0009333_abnormal_splenocyte_physiolog1.11620910
60MP0001905_abnormal_dopamine_level1.08625255
61MP0008775_abnormal_heart_ventricle1.08401668
62MP0001873_stomach_inflammation1.07399875
63MP0008058_abnormal_DNA_repair1.04969917
64MP0009745_abnormal_behavioral_response1.04864889
65MP0002452_abnormal_antigen_presenting1.04525023
66MP0006276_abnormal_autonomic_nervous1.04407818
67MP0002751_abnormal_autonomic_nervous1.03770835
68MP0006036_abnormal_mitochondrial_physio1.02915452
69MP0000613_abnormal_salivary_gland1.02216918
70MP0003718_maternal_effect1.02185939
71MP0001819_abnormal_immune_cell1.01115130
72MP0002420_abnormal_adaptive_immunity0.99783458
73MP0001970_abnormal_pain_threshold0.99107419
74MP0003121_genomic_imprinting0.96062276
75MP0005253_abnormal_eye_physiology0.95934908
76MP0005423_abnormal_somatic_nervous0.95397908
77MP0006035_abnormal_mitochondrial_morpho0.95090843
78MP0009764_decreased_sensitivity_to0.94206435
79MP0001293_anophthalmia0.93871324
80MP0005257_abnormal_intraocular_pressure0.93638283
81MP0003880_abnormal_central_pattern0.92546161
82MP0005410_abnormal_fertilization0.90431786
83MP0003866_abnormal_defecation0.88260487
84MP0000631_abnormal_neuroendocrine_gland0.88243586
85MP0001440_abnormal_grooming_behavior0.87779040
86MP0003186_abnormal_redox_activity0.86470472
87MP0004742_abnormal_vestibular_system0.86425741
88MP0002282_abnormal_trachea_morphology0.86031816
89MP0002277_abnormal_respiratory_mucosa0.86023794
90MP0001984_abnormal_olfaction0.81936449
91MP0002735_abnormal_chemical_nociception0.81811158
92MP0000427_abnormal_hair_cycle0.81282613
93MP0010155_abnormal_intestine_physiology0.78852202
94MP0003252_abnormal_bile_duct0.77689209
95MP0003567_abnormal_fetal_cardiomyocyte0.77656263
96MP0003136_yellow_coat_color0.76297759
97MP0003137_abnormal_impulse_conducting0.72169280
98MP0001845_abnormal_inflammatory_respons0.71141533
99MP0005025_abnormal_response_to0.68494143
100MP0005332_abnormal_amino_acid0.68161173

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)3.91807216
2Congenital stationary night blindness (HP:0007642)3.84925291
3Mitochondrial inheritance (HP:0001427)3.63008476
4IgG deficiency (HP:0004315)3.59524535
5Congenital, generalized hypertrichosis (HP:0004540)3.48423554
6Pancreatic cysts (HP:0001737)3.46494714
7Acute encephalopathy (HP:0006846)3.41714977
8Increased CSF lactate (HP:0002490)3.36438491
9Progressive macrocephaly (HP:0004481)3.34742089
10Hepatocellular necrosis (HP:0001404)3.31578198
11Abnormal mitochondria in muscle tissue (HP:0008316)3.28227045
12Abnormality of midbrain morphology (HP:0002418)3.25152005
13Molar tooth sign on MRI (HP:0002419)3.25152005
14Abolished electroretinogram (ERG) (HP:0000550)3.10255318
15Nephronophthisis (HP:0000090)3.03075874
16Aplastic anemia (HP:0001915)2.98793674
17Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94390114
18Hepatic necrosis (HP:0002605)2.93838763
19Pancreatic fibrosis (HP:0100732)2.90616991
20True hermaphroditism (HP:0010459)2.88567595
21Stomatitis (HP:0010280)2.88505863
223-Methylglutaconic aciduria (HP:0003535)2.88352354
23Increased hepatocellular lipid droplets (HP:0006565)2.88164493
24Elevated erythrocyte sedimentation rate (HP:0003565)2.83157606
25Abnormal rod and cone electroretinograms (HP:0008323)2.76510536
26Type II lissencephaly (HP:0007260)2.72586605
27Lipid accumulation in hepatocytes (HP:0006561)2.67066204
28Methylmalonic acidemia (HP:0002912)2.64827328
29Abnormality of the prostate (HP:0008775)2.57235187
30Abnormality of the renal medulla (HP:0100957)2.57072384
31Abnormality of the renal cortex (HP:0011035)2.55297670
32Hypoplasia of the fovea (HP:0007750)2.55286709
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.55286709
34Hypoproteinemia (HP:0003075)2.53775698
35Cerebral edema (HP:0002181)2.51981926
36Optic disc pallor (HP:0000543)2.51541944
37Abnormality of the fovea (HP:0000493)2.50090659
38Increased corneal curvature (HP:0100692)2.49571335
39Keratoconus (HP:0000563)2.49571335
40Decreased electroretinogram (ERG) amplitude (HP:0000654)2.48973314
41Decreased central vision (HP:0007663)2.41235313
42Pendular nystagmus (HP:0012043)2.41142720
43Severe combined immunodeficiency (HP:0004430)2.40656854
44Reticulocytopenia (HP:0001896)2.40167522
45Attenuation of retinal blood vessels (HP:0007843)2.34844465
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.32019987
47Absent/shortened dynein arms (HP:0200106)2.32019987
48Increased serum lactate (HP:0002151)2.27801779
49Increased IgM level (HP:0003496)2.27425069
50Abnormality of B cell number (HP:0010975)2.23560910
51Thyroiditis (HP:0100646)2.22912380
52Hyperalaninemia (HP:0003348)2.20496162
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20496162
54Abnormality of alanine metabolism (HP:0010916)2.20496162
55Stomach cancer (HP:0012126)2.18071800
56Pancytopenia (HP:0001876)2.13264334
57Colon cancer (HP:0003003)2.13073665
58Renal Fanconi syndrome (HP:0001994)2.12452999
59Medial flaring of the eyebrow (HP:0010747)2.10223198
60Methylmalonic aciduria (HP:0012120)2.08994184
61Type 2 muscle fiber atrophy (HP:0003554)2.07057947
62Lactic acidosis (HP:0003128)2.06970428
63Abnormal drinking behavior (HP:0030082)2.02465164
64Polydipsia (HP:0001959)2.02465164
65Abnormality of cells of the erythroid lineage (HP:0012130)2.00788621
66Optic nerve hypoplasia (HP:0000609)1.99095224
67Absent thumb (HP:0009777)1.97319714
68Aplasia/hypoplasia of the uterus (HP:0008684)1.96704324
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96134021
70Abnormality of eosinophils (HP:0001879)1.94913440
71Renal cortical cysts (HP:0000803)1.94176036
72Oral leukoplakia (HP:0002745)1.94122977
73Exertional dyspnea (HP:0002875)1.93262994
74Sclerocornea (HP:0000647)1.91015546
75Abnormality of T cell number (HP:0011839)1.89411273
76Lethargy (HP:0001254)1.88899664
77Macrocytic anemia (HP:0001972)1.86434668
78Leukodystrophy (HP:0002415)1.86145507
79Hyperglycinuria (HP:0003108)1.85224848
80Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.85210022
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.84530003
82Respiratory failure (HP:0002878)1.83400076
83Abnormal ciliary motility (HP:0012262)1.82665199
84Tubular atrophy (HP:0000092)1.82629409
85Increased intramyocellular lipid droplets (HP:0012240)1.82598479
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.82115648
87T lymphocytopenia (HP:0005403)1.81066162
88Abnormal number of erythroid precursors (HP:0012131)1.79688178
89Polyuria (HP:0000103)1.77858857
90Constricted visual fields (HP:0001133)1.77545584
91Abnormality of the pons (HP:0007361)1.77235514
92Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75437511
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75437511
94Combined immunodeficiency (HP:0005387)1.74043311
95B lymphocytopenia (HP:0010976)1.73964694
96Cerebellar dysplasia (HP:0007033)1.73848558
97Hypoplasia of the uterus (HP:0000013)1.71423884
98Septo-optic dysplasia (HP:0100842)1.71354526
99Abnormality of the ileum (HP:0001549)1.70985078
100Abnormality of T cells (HP:0002843)1.70671105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NUAK13.32357131
2TAOK33.32323104
3VRK23.05982264
4TXK3.03216158
5TLK12.76965510
6ZAK2.74944146
7MAP4K22.74265614
8GRK12.72612444
9ADRBK22.40248236
10PINK12.39755165
11FRK2.25151969
12STK162.20194601
13CDK192.04468413
14MST41.79295975
15EIF2AK31.73111214
16WNK41.73079781
17VRK11.71544971
18TIE11.70523489
19OXSR11.62434772
20MAPK131.54762248
21WNK31.51019458
22KDR1.42438822
23MAP3K121.40676077
24BMPR1B1.38426074
25TEC1.36280937
26BMPR21.30829639
27ITK1.30585087
28IKBKB1.29985870
29STK391.28966388
30BCKDK1.25563689
31NME11.21524272
32MAP4K11.20115784
33KIT1.17457291
34PHKG11.15720565
35PHKG21.15720565
36MAP3K141.14489816
37PIK3CA1.10584604
38CDK81.06943659
39DYRK21.05188961
40SRPK11.04374989
41INSRR1.02507083
42CSNK1G30.95511723
43TSSK60.95287991
44EIF2AK20.91478518
45PIK3CG0.88449129
46EIF2AK10.87230891
47GRK60.85202969
48MYLK0.79723786
49SYK0.78472133
50MKNK10.78010848
51OBSCN0.76892300
52CSNK1A1L0.76547026
53PLK40.76133122
54PTK2B0.74914839
55MAP3K40.74143643
56FLT30.73810358
57CSNK1G20.73805889
58ERBB30.73527209
59CSNK1G10.72846866
60PLK30.72791995
61RPS6KA50.72438905
62FES0.71851799
63DAPK10.71730086
64CAMKK20.71525151
65MATK0.70373473
66IKBKE0.69230443
67NME20.68415357
68PASK0.67796859
69PRKCQ0.65169401
70MAPKAPK50.65130676
71MKNK20.62334300
72MAPKAPK30.61492407
73PLK20.61388068
74ADRBK10.61163082
75MAPK150.57403413
76STK38L0.55816792
77LYN0.54564549
78CHUK0.52611112
79LCK0.52150003
80TAF10.51451900
81BTK0.50922028
82DAPK20.50495708
83BUB10.46955061
84GRK50.45285259
85CSF1R0.45284929
86TRIM280.45026913
87PRKCG0.43860548
88DAPK30.42721004
89IGF1R0.42368438
90TGFBR10.40792165
91PRKCE0.37530719
92PRKACA0.37292561
93MAP3K130.34679830
94ATR0.33941652
95MAP2K20.33752090
96NEK10.33317152
97ACVR1B0.31977851
98CSNK2A20.31913014
99PRKCA0.31691151
100CSNK1A10.31396169

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053103.90271379
2Proteasome_Homo sapiens_hsa030503.61284498
3Allograft rejection_Homo sapiens_hsa053303.22701945
4Ribosome_Homo sapiens_hsa030103.17226028
5Oxidative phosphorylation_Homo sapiens_hsa001903.13160039
6Autoimmune thyroid disease_Homo sapiens_hsa053203.02257309
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.95704577
8Graft-versus-host disease_Homo sapiens_hsa053322.76764471
9Parkinsons disease_Homo sapiens_hsa050122.57589062
10Protein export_Homo sapiens_hsa030602.42418284
11Type I diabetes mellitus_Homo sapiens_hsa049402.37396881
12RNA polymerase_Homo sapiens_hsa030202.11827084
13Caffeine metabolism_Homo sapiens_hsa002322.08277452
14Primary immunodeficiency_Homo sapiens_hsa053402.05809147
15Antigen processing and presentation_Homo sapiens_hsa046121.93296253
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92915752
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.83759325
18Linoleic acid metabolism_Homo sapiens_hsa005911.80536451
19Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77197715
20Homologous recombination_Homo sapiens_hsa034401.73007323
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68603762
22Phototransduction_Homo sapiens_hsa047441.64218563
23Alzheimers disease_Homo sapiens_hsa050101.62427407
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53596845
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52526036
26Cardiac muscle contraction_Homo sapiens_hsa042601.52061146
27Huntingtons disease_Homo sapiens_hsa050161.46612413
28RNA degradation_Homo sapiens_hsa030181.44637835
29One carbon pool by folate_Homo sapiens_hsa006701.41382118
30Rheumatoid arthritis_Homo sapiens_hsa053231.39843775
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39716171
32Fanconi anemia pathway_Homo sapiens_hsa034601.20921895
33Nitrogen metabolism_Homo sapiens_hsa009101.15274581
34Propanoate metabolism_Homo sapiens_hsa006401.15014542
35Tryptophan metabolism_Homo sapiens_hsa003801.07628273
36Mismatch repair_Homo sapiens_hsa034301.05774876
37Hematopoietic cell lineage_Homo sapiens_hsa046401.04670665
38Maturity onset diabetes of the young_Homo sapiens_hsa049501.01781010
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96743782
40Pyrimidine metabolism_Homo sapiens_hsa002400.91721589
41Arachidonic acid metabolism_Homo sapiens_hsa005900.89443122
42Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88644135
43RNA transport_Homo sapiens_hsa030130.86386618
44Nucleotide excision repair_Homo sapiens_hsa034200.86185731
45Purine metabolism_Homo sapiens_hsa002300.85210788
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85103088
47Peroxisome_Homo sapiens_hsa041460.82907526
48Systemic lupus erythematosus_Homo sapiens_hsa053220.82803440
49Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82220351
50Viral myocarditis_Homo sapiens_hsa054160.81839054
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.80927170
52Chemical carcinogenesis_Homo sapiens_hsa052040.80662731
53Staphylococcus aureus infection_Homo sapiens_hsa051500.79571605
54Spliceosome_Homo sapiens_hsa030400.78829568
55DNA replication_Homo sapiens_hsa030300.78407286
56Ether lipid metabolism_Homo sapiens_hsa005650.78110193
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76506624
58Olfactory transduction_Homo sapiens_hsa047400.76404661
59Basal transcription factors_Homo sapiens_hsa030220.74851253
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73767447
61Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.71200972
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.59282564
63Cyanoamino acid metabolism_Homo sapiens_hsa004600.58667266
64Fat digestion and absorption_Homo sapiens_hsa049750.58663531
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.56437012
66Leishmaniasis_Homo sapiens_hsa051400.55831747
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55171171
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54390387
69T cell receptor signaling pathway_Homo sapiens_hsa046600.52286402
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.51181316
71Base excision repair_Homo sapiens_hsa034100.50321375
72Butanoate metabolism_Homo sapiens_hsa006500.48325464
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48123591
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.47830370
75Metabolic pathways_Homo sapiens_hsa011000.46369751
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.45019211
77Retinol metabolism_Homo sapiens_hsa008300.43980408
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43372054
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42882196
80Taste transduction_Homo sapiens_hsa047420.42723453
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.39771871
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.38811825
83Morphine addiction_Homo sapiens_hsa050320.37913487
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37579583
85Collecting duct acid secretion_Homo sapiens_hsa049660.37343855
86Non-homologous end-joining_Homo sapiens_hsa034500.36954509
87Nicotine addiction_Homo sapiens_hsa050330.33482285
88Salivary secretion_Homo sapiens_hsa049700.32647546
89beta-Alanine metabolism_Homo sapiens_hsa004100.32371079
90Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.31013722
91Serotonergic synapse_Homo sapiens_hsa047260.29635067
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.26797476
93Epstein-Barr virus infection_Homo sapiens_hsa051690.25969245
94Ovarian steroidogenesis_Homo sapiens_hsa049130.25549656
95Vitamin digestion and absorption_Homo sapiens_hsa049770.24462973
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.23289284
97Herpes simplex infection_Homo sapiens_hsa051680.23055029
98Regulation of autophagy_Homo sapiens_hsa041400.22721370
99Sulfur metabolism_Homo sapiens_hsa009200.20470536
100Drug metabolism - other enzymes_Homo sapiens_hsa009830.19130950

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