ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of skeletal muscle contraction (GO:0014819)	9.57254825
2	regulation of relaxation of muscle (GO:1901077)	8.29194788
3	myofibril assembly (GO:0030239)	8.19311524
4	sarcomere organization (GO:0045214)	7.98696638
5	actin filament-based movement (GO:0030048)	7.91050699
6	striated muscle contraction (GO:0006941)	7.86049880
7	positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	7.32620235
8	creatine metabolic process (GO:0006600)	6.97044045
9	cardiac myofibril assembly (GO:0055003)	6.85865678
10	response to muscle activity (GO:0014850)	6.83936162
11	response to stimulus involved in regulation of muscle adaptation (GO:0014874)	6.75820007
12	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.64631371
13	skeletal muscle fiber development (GO:0048741)	6.47309230
14	response to inactivity (GO:0014854)	6.32468988
15	cardiac muscle contraction (GO:0060048)	6.22830131
16	actomyosin structure organization (GO:0031032)	5.95543280
17	myotube cell development (GO:0014904)	5.90340803
18	muscle contraction (GO:0006936)	5.88705364
19	regulation of actin filament-based movement (GO:1903115)	5.73791429
20	skeletal muscle adaptation (GO:0043501)	5.59917858
21	cardiac muscle hypertrophy (GO:0003300)	5.38291292
22	regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	5.29326874
23	muscle system process (GO:0003012)	5.26989324
24	plasma membrane repair (GO:0001778)	5.25323911
25	glycogen catabolic process (GO:0005980)	5.25253908
26	negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	5.23754180
27	striated muscle hypertrophy (GO:0014897)	5.13204939
28	regulation of cell communication by electrical coupling (GO:0010649)	5.04140856
29	muscle fiber development (GO:0048747)	5.01370244
30	NADH metabolic process (GO:0006734)	4.95492696
31	glucan catabolic process (GO:0009251)	4.93929726
32	skeletal muscle tissue development (GO:0007519)	4.85403519
33	glycogen biosynthetic process (GO:0005978)	4.84919040
34	glucan biosynthetic process (GO:0009250)	4.84919040
35	striated muscle adaptation (GO:0014888)	4.71594545
36	cellular polysaccharide catabolic process (GO:0044247)	4.64916406
37	negative regulation of potassium ion transmembrane transport (GO:1901380)	4.63963363
38	muscle hypertrophy (GO:0014896)	4.57469962
39	muscle tissue morphogenesis (GO:0060415)	4.47410205
40	cardiac muscle cell development (GO:0055013)	4.45627817
41	adult heart development (GO:0007512)	4.43228967
42	cardiac muscle tissue morphogenesis (GO:0055008)	4.41444766
43	regulation of striated muscle contraction (GO:0006942)	4.27502291
44	regulation of the force of heart contraction (GO:0002026)	4.26611377
45	striated muscle cell development (GO:0055002)	4.24799916
46	muscle cell cellular homeostasis (GO:0046716)	4.23454969
47	skeletal muscle tissue regeneration (GO:0043403)	4.21814701
48	polysaccharide catabolic process (GO:0000272)	4.18831022
49	positive regulation of myotube differentiation (GO:0010831)	4.17310688
50	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	4.15712765
51	muscle cell fate commitment (GO:0042693)	4.15005072
52	positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	4.14303003
53	cardiac cell development (GO:0055006)	4.13749906
54	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO	4.10044774
55	2-oxoglutarate metabolic process (GO:0006103)	4.01771864
56	fructose metabolic process (GO:0006000)	3.97529619
57	regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	3.94432177
58	muscle organ development (GO:0007517)	3.93687307
59	muscle structure development (GO:0061061)	3.93681302
60	cardiac muscle adaptation (GO:0014887)	3.85835393
61	cardiac muscle hypertrophy in response to stress (GO:0014898)	3.85835393
62	muscle hypertrophy in response to stress (GO:0003299)	3.85835393
63	glycogen metabolic process (GO:0005977)	3.83051664
64	muscle adaptation (GO:0043500)	3.79304776
65	regulation of calcium ion transmembrane transporter activity (GO:1901019)	3.79069139
66	regulation of calcium ion transmembrane transport (GO:1903169)	3.79069139
67	glucan metabolic process (GO:0044042)	3.75502377
68	cellular glucan metabolic process (GO:0006073)	3.75502377
69	striated muscle atrophy (GO:0014891)	3.70553620
70	muscle organ morphogenesis (GO:0048644)	3.70064698
71	regulation of calcineurin-NFAT signaling cascade (GO:0070884)	3.68891040
72	tricarboxylic acid cycle (GO:0006099)	3.67592036
73	carnitine shuttle (GO:0006853)	3.66967425
74	gluconeogenesis (GO:0006094)	3.65593997
75	muscle cell development (GO:0055001)	3.64029398
76	regulation of skeletal muscle cell differentiation (GO:2001014)	3.58687688
77	response to activity (GO:0014823)	3.57616573
78	myoblast fusion (GO:0007520)	3.55527677
79	regulation of myoblast differentiation (GO:0045661)	3.54597729
80	negative regulation of calcium ion transmembrane transport (GO:1903170)	3.53340571
81	negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	3.53340571
82	striated muscle tissue development (GO:0014706)	3.43868277
83	neuronal action potential propagation (GO:0019227)	3.41929134
84	positive regulation of cation channel activity (GO:2001259)	3.39789989
85	positive regulation of myoblast differentiation (GO:0045663)	3.36246980
86	regulation of muscle system process (GO:0090257)	3.35460575
87	relaxation of muscle (GO:0090075)	3.34267487
88	muscle atrophy (GO:0014889)	3.31646134
89	heart process (GO:0003015)	3.31551334
90	heart contraction (GO:0060047)	3.31551334
91	regulation of sarcomere organization (GO:0060297)	3.28780872
92	regulation of muscle contraction (GO:0006937)	3.26578080
93	hexose biosynthetic process (GO:0019319)	3.25294875
94	regulation of ATP catabolic process (GO:1903289)	3.22848702
95	regulation of ATPase activity (GO:0043462)	3.22848702
96	actin-myosin filament sliding (GO:0033275)	12.9328549
97	muscle filament sliding (GO:0030049)	12.9328549
98	sarcoplasmic reticulum calcium ion transport (GO:0070296)	11.0740824
99	actin-mediated cell contraction (GO:0070252)	10.6508504
100	skeletal muscle contraction (GO:0003009)	10.0356475

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.87089877
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.74866558
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.74075334
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.73034280
5	TBX20_22328084_ChIP-Seq_HEART_Mouse	3.20159809
6	TBX20_22080862_ChIP-Seq_HEART_Mouse	3.20159809
7	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.10248999
8	EP300_21415370_ChIP-Seq_HL-1_Mouse	3.05518970
9	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.93258155
10	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.91865055
11	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	2.88765974
12	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.78255323
13	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	2.57427150
14	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	2.41511376
15	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.28892082
16	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.17493228
17	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	2.14252133
18	GATA4_21415370_ChIP-Seq_HL-1_Mouse	1.96835032
19	NKX2-5_21415370_ChIP-Seq_HL-1_Mouse	1.87768157
20	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.84120505
21	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.77728487
22	ZNF263_19887448_ChIP-Seq_K562_Human	1.60474243
23	CTCF_27219007_Chip-Seq_Bcells_Human	1.58441643
24	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.57718103
25	NFIB_24661679_ChIP-Seq_LUNG_Mouse	1.53068033
26	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.51307316
27	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.50124060
28	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.47907722
29	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.44095087
30	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.41014416
31	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	1.39059711
32	DROSHA_22980978_ChIP-Seq_HELA_Human	1.33676458
33	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.31717465
34	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.30914822
35	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.28649367
36	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.25933877
37	AR_21572438_ChIP-Seq_LNCaP_Human	1.17367562
38	SMC3_22415368_ChIP-Seq_MEFs_Mouse	1.16069112
39	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16003122
40	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15424892
41	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.13480404
42	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.12013022
43	IGF1R_20145208_ChIP-Seq_DFB_Human	1.08464590
44	MYC_27129775_Chip-Seq_CORNEA_Mouse	1.05354057
45	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	1.03742395
46	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.02392345
47	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.01785851
48	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.00217574
49	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.00214558
50	OCT4_20526341_ChIP-Seq_ESCs_Human	0.99886117
51	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99811519
52	SPI1_20517297_ChIP-Seq_HL60_Human	0.99073985
53	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.98339816
54	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.97986961
55	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.97583509
56	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.97408272
57	PPARA_22158963_ChIP-Seq_LIVER_Mouse	0.97337240
58	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.96006907
59	CLOCK_20551151_ChIP-Seq_293T_Human	0.95606186
60	SA1_27219007_Chip-Seq_Bcells_Human	0.93260705
61	RXR_22158963_ChIP-Seq_LIVER_Mouse	0.91908639
62	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.91198410
63	RUNX2_24764292_ChIP-Seq_MC3T3_Mouse	0.90945723
64	LXR_22158963_ChIP-Seq_LIVER_Mouse	0.87687034
65	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.87537349
66	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.87091425
67	CTCF_21964334_Chip-Seq_Bcells_Human	0.85359062
68	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.85302312
69	SMAD3_21741376_ChIP-Seq_HESCs_Human	0.85190703
70	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	0.85067563
71	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.83832085
72	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.83832085
73	PRDM14_21183938_ChIP-Seq_MESCs_Mouse	0.83679387
74	PCGF2_27294783_Chip-Seq_ESCs_Mouse	0.80978536
75	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.79805055
76	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.79677546
77	GATA1_19941827_ChIP-Seq_MEL86_Mouse	0.78769892
78	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.78726970
79	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.77900442
80	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.77392647
81	HTT_18923047_ChIP-ChIP_STHdh_Human	0.76887413
82	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.76632919
83	CTCF_27219007_Chip-Seq_ERYTHROID_Human	0.76575598
84	KDM2B_26808549_Chip-Seq_DND41_Human	0.76222899
85	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.76029138
86	GBX2_23144817_ChIP-Seq_PC3_Human	0.75322591
87	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.74904904
88	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.74163869
89	DPY_21335234_ChIP-Seq_ESCs_Mouse	0.73913668
90	ISL1_27105846_Chip-Seq_CPCs_Mouse	0.73635795
91	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.73610134
92	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.73037059
93	EGR1_19032775_ChIP-ChIP_M12_Human	0.72632581
94	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.72365500
95	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.72329940
96	GATA6_21074721_ChIP-Seq_CACO-2_Human	0.71273284
97	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.70478373
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.69553221
99	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.69390281
100	GF1_26923725_Chip-Seq_HPCs_Mouse	0.69062403

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0004145_abnormal_muscle_electrophysio	6.83174060
2	MP0003646_muscle_fatigue	6.75530871
3	MP0000751_myopathy	6.31874150
4	MP0000749_muscle_degeneration	5.70819233
5	MP0004036_abnormal_muscle_relaxation	4.59621704
6	MP0002106_abnormal_muscle_physiology	3.80353330
7	MP0004087_abnormal_muscle_fiber	3.59500655
8	MP0004084_abnormal_cardiac_muscle	3.52759306
9	MP0000747_muscle_weakness	3.48924689
10	MP0000759_abnormal_skeletal_muscle	3.39723735
11	MP0005451_abnormal_body_composition	3.35647608
12	MP0005369_muscle_phenotype	3.19287623
13	MP0000750_abnormal_muscle_regeneration	3.00962574
14	MP0002332_abnormal_exercise_endurance	3.00532035
15	MP0002269_muscular_atrophy	2.98349653
16	MP0005620_abnormal_muscle_contractility	2.97307696
17	MP0005330_cardiomyopathy	2.90142729
18	MP0004130_abnormal_muscle_cell	2.83518253
19	MP0004233_abnormal_muscle_weight	2.76512729
20	MP0002972_abnormal_cardiac_muscle	2.38908659
21	MP0002837_dystrophic_cardiac_calcinosis	2.38141029
22	MP0000733_abnormal_muscle_development	2.17097804
23	MP0004215_abnormal_myocardial_fiber	2.07558398
24	MP0002108_abnormal_muscle_morphology	1.88452341
25	MP0010630_abnormal_cardiac_muscle	1.82769697
26	MP0006036_abnormal_mitochondrial_physio	1.79150666
27	MP0004484_altered_response_of	1.75511797
28	MP0002127_abnormal_cardiovascular_syste	1.60548406
29	MP0004510_myositis	1.59229704
30	MP0001544_abnormal_cardiovascular_syste	1.51109521
31	MP0005385_cardiovascular_system_phenoty	1.51109521
32	MP0004270_analgesia	1.48609566
33	MP0000013_abnormal_adipose_tissue	1.47239492
34	MP0006138_congestive_heart_failure	1.43079200
35	MP0005266_abnormal_metabolism	1.34530887
36	MP0003221_abnormal_cardiomyocyte_apopto	1.33223440
37	MP0008775_abnormal_heart_ventricle	1.28286116
38	MP0003137_abnormal_impulse_conducting	1.20400914
39	MP0003950_abnormal_plasma_membrane	1.14557677
40	MP0001661_extended_life_span	1.08123920
41	MP0004185_abnormal_adipocyte_glucose	1.06890793
42	MP0002971_abnormal_brown_adipose	1.03810900
43	MP0004085_abnormal_heartbeat	0.91995265
44	MP0005666_abnormal_adipose_tissue	0.90139696
45	MP0002822_catalepsy	0.88391406
46	MP0003828_pulmonary_edema	0.84461578
47	MP0005375_adipose_tissue_phenotype	0.84428834
48	MP0005670_abnormal_white_adipose	0.82381342
49	MP0004147_increased_porphyrin_level	0.76835937
50	MP0000003_abnormal_adipose_tissue	0.76244425
51	MP0003045_fibrosis	0.72864601
52	MP0000266_abnormal_heart_morphology	0.69793034
53	MP0000372_irregular_coat_pigmentation	0.59907138
54	MP0009780_abnormal_chondrocyte_physiolo	0.56263762
55	MP0004134_abnormal_chest_morphology	0.54645097
56	MP0001299_abnormal_eye_distance/	0.53732438
57	MP0003879_abnormal_hair_cell	0.52278172
58	MP0003656_abnormal_erythrocyte_physiolo	0.52249404
59	MP0004043_abnormal_pH_regulation	0.47902968
60	MP0002128_abnormal_blood_circulation	0.45115264
61	MP0002078_abnormal_glucose_homeostasis	0.43616604
62	MP0008569_lethality_at_weaning	0.41182192
63	MP0005083_abnormal_biliary_tract	0.38733609
64	MP0002638_abnormal_pupillary_reflex	0.38347452
65	MP0005167_abnormal_blood-brain_barrier	0.38324940
66	MP0009672_abnormal_birth_weight	0.37209189
67	MP0005584_abnormal_enzyme/coenzyme_acti	0.36886787
68	MP0005165_increased_susceptibility_to	0.36522756
69	MP0010030_abnormal_orbit_morphology	0.36259237
70	MP0005376_homeostasis/metabolism_phenot	0.35399983
71	MP0004142_abnormal_muscle_tone	0.35306872
72	MP0000762_abnormal_tongue_morphology	0.35082443
73	MP0002114_abnormal_axial_skeleton	0.31219239
74	MP0002734_abnormal_mechanical_nocicepti	0.30706079
75	MP0005166_decreased_susceptibility_to	0.29998725
76	MP0003948_abnormal_gas_homeostasis	0.29990733
77	MP0005452_abnormal_adipose_tissue	0.29668570
78	MP0000230_abnormal_systemic_arterial	0.29042799
79	MP0009250_abnormal_appendicular_skeleto	0.28929139
80	MP0005535_abnormal_body_temperature	0.28331948
81	MP0001346_abnormal_lacrimal_gland	0.26591353
82	MP0005187_abnormal_penis_morphology	0.26373067
83	MP0006035_abnormal_mitochondrial_morpho	0.26298330
84	MP0005319_abnormal_enzyme/_coenzyme	0.26172374
85	MP0002896_abnormal_bone_mineralization	0.25688208
86	MP0003941_abnormal_skin_development	0.24841288
87	MP0004858_abnormal_nervous_system	0.22899789
88	MP0005332_abnormal_amino_acid	0.22033553
89	MP0005334_abnormal_fat_pad	0.20746915
90	MP0001943_abnormal_respiration	0.20581455
91	MP0002249_abnormal_larynx_morphology	0.20026097
92	MP0005423_abnormal_somatic_nervous	0.19837381
93	MP0002066_abnormal_motor_capabilities/c	0.19624084
94	MP0002234_abnormal_pharynx_morphology	0.17940624
95	MP0003567_abnormal_fetal_cardiomyocyte	0.16642505
96	MP0004924_abnormal_behavior	0.15063255
97	MP0005386_behavior/neurological_phenoty	0.15063255
98	MP0001529_abnormal_vocalization	0.15037152
99	MP0008874_decreased_physiological_sensi	0.14670799
100	MP0006276_abnormal_autonomic_nervous	0.14552705

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type 1 muscle fiber predominance (HP:0003803)	8.37030068
2	Exercise-induced myalgia (HP:0003738)	7.92717190
3	Exercise-induced muscle cramps (HP:0003710)	7.35456844
4	Muscle hypertrophy of the lower extremities (HP:0008968)	6.43950863
5	Distal arthrogryposis (HP:0005684)	5.74994350
6	Calf muscle hypertrophy (HP:0008981)	5.70859375
7	Myopathic facies (HP:0002058)	5.63846297
8	EMG: myopathic abnormalities (HP:0003458)	5.36706946
9	Muscle fiber splitting (HP:0003555)	5.11388808
10	Round ear (HP:0100830)	4.80110417
11	Rhabdomyolysis (HP:0003201)	4.80092647
12	Hyporeflexia of lower limbs (HP:0002600)	4.79466076
13	Abnormality of the calf musculature (HP:0001430)	4.77378629
14	Centrally nucleated skeletal muscle fibers (HP:0003687)	4.70486364
15	Myoglobinuria (HP:0002913)	4.70151801
16	Ulnar deviation of the wrist (HP:0003049)	4.51587440
17	Subaortic stenosis (HP:0001682)	4.48987259
18	Abnormality of the left ventricular outflow tract (HP:0011103)	4.48987259
19	Neck muscle weakness (HP:0000467)	4.44406113
20	Rimmed vacuoles (HP:0003805)	4.34863218
21	Abnormality of skeletal muscle fiber size (HP:0012084)	4.24487498
22	Difficulty running (HP:0009046)	4.00387056
23	Calcaneovalgus deformity (HP:0001848)	3.93835244
24	Distal lower limb muscle weakness (HP:0009053)	3.79348037
25	Increased connective tissue (HP:0009025)	3.79075608
26	Muscle stiffness (HP:0003552)	3.78414681
27	Sudden death (HP:0001699)	3.76358099
28	Asymmetric septal hypertrophy (HP:0001670)	3.59405654
29	Increased variability in muscle fiber diameter (HP:0003557)	3.55818882
30	Absent phalangeal crease (HP:0006109)	3.55780739
31	Deformed tarsal bones (HP:0008119)	3.49233942
32	Myotonia (HP:0002486)	3.48820679
33	Areflexia of lower limbs (HP:0002522)	3.38686723
34	Bundle branch block (HP:0011710)	3.37335607
35	Malignant hyperthermia (HP:0002047)	3.33030533
36	Frequent falls (HP:0002359)	3.30662163
37	EMG: neuropathic changes (HP:0003445)	3.16298608
38	Ventricular tachycardia (HP:0004756)	3.03091028
39	Generalized muscle weakness (HP:0003324)	2.97831019
40	Abnormal finger flexion creases (HP:0006143)	2.95089445
41	Mildly elevated creatine phosphokinase (HP:0008180)	2.91890146
42	Distal lower limb amyotrophy (HP:0008944)	2.79372062
43	Dilated cardiomyopathy (HP:0001644)	2.72413556
44	Fetal akinesia sequence (HP:0001989)	2.69078177
45	Lipoatrophy (HP:0100578)	2.53405190
46	Bulbar palsy (HP:0001283)	2.51503934
47	Weak cry (HP:0001612)	2.47361177
48	Abnormality of the neuromuscular junction (HP:0003398)	2.46283935
49	Fatigable weakness (HP:0003473)	2.46283935
50	Slender build (HP:0001533)	2.42171470
51	Gowers sign (HP:0003391)	2.41795056
52	Progressive muscle weakness (HP:0003323)	2.37753055
53	Scapular winging (HP:0003691)	2.33047118
54	Limb-girdle muscle atrophy (HP:0003797)	2.31776751
55	Hip contracture (HP:0003273)	2.31761363
56	Hyperkalemia (HP:0002153)	2.29344299
57	Difficulty climbing stairs (HP:0003551)	2.29088618
58	Abnormality of the calcaneus (HP:0008364)	2.27925118
59	Muscular dystrophy (HP:0003560)	2.17807377
60	Spinal rigidity (HP:0003306)	2.16615051
61	Heart block (HP:0012722)	2.15980505
62	Lower limb amyotrophy (HP:0007210)	2.12585476
63	Waddling gait (HP:0002515)	2.08157003
64	Abnormality of the foot musculature (HP:0001436)	2.05900288
65	Proximal amyotrophy (HP:0007126)	2.05704945
66	Abnormal atrioventricular conduction (HP:0005150)	2.03615282
67	Nemaline bodies (HP:0003798)	11.0259277
68	Muscle fiber inclusion bodies (HP:0100299)	11.0165557
69	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	10.8114237
70	Ragged-red muscle fibers (HP:0003200)	1.94412685
71	Popliteal pterygium (HP:0009756)	1.92329631
72	Abnormality of the shoulder girdle musculature (HP:0001435)	1.91409230
73	Ventricular arrhythmia (HP:0004308)	1.86844451
74	Foot dorsiflexor weakness (HP:0009027)	1.84701401
75	Long clavicles (HP:0000890)	1.82760792
76	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.81426697
77	Abnormality of the hip-girdle musculature (HP:0001445)	1.79229500
78	Abnormality of the musculature of the pelvis (HP:0001469)	1.79229500
79	Exercise intolerance (HP:0003546)	1.77740001
80	Shoulder girdle muscle weakness (HP:0003547)	1.75171031
81	Pelvic girdle muscle weakness (HP:0003749)	1.74911433
82	Limb-girdle muscle weakness (HP:0003325)	1.70938623
83	Facial diplegia (HP:0001349)	1.70587231
84	Paralysis (HP:0003470)	1.70022211
85	Type 2 muscle fiber atrophy (HP:0003554)	1.68675656
86	Nonprogressive disorder (HP:0003680)	1.68628220
87	Metatarsus adductus (HP:0001840)	1.57062833
88	Limited hip movement (HP:0008800)	1.55892369
89	Muscle fiber atrophy (HP:0100295)	1.55624416
90	Increased intramyocellular lipid droplets (HP:0012240)	1.55041359
91	Atrial fibrillation (HP:0005110)	1.53792211
92	Ulnar deviation of finger (HP:0009465)	1.47606264
93	Increased muscle lipid content (HP:0009058)	1.44779077
94	Steppage gait (HP:0003376)	1.40242259
95	Primary atrial arrhythmia (HP:0001692)	1.39030245
96	Abnormality of placental membranes (HP:0011409)	1.38503211
97	Amniotic constriction ring (HP:0009775)	1.38503211
98	Supraventricular tachycardia (HP:0004755)	1.34688486
99	Oligomenorrhea (HP:0000876)	1.32684892
100	Left ventricular hypertrophy (HP:0001712)	1.31299514

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TTN	6.50629576
2	PHKG1	6.04931035
3	PHKG2	6.04931035
4	PIK3CG	2.90588986
5	MAPK12	2.00995417
6	OBSCN	10.6869687
7	MUSK	1.91943798
8	MAP2K3	1.83345655
9	PINK1	1.76060570
10	MAP3K7	1.67827503
11	MAPKAPK3	1.57744236
12	NME1	1.20700720
13	MAP2K4	1.15811687
14	TRPM7	1.11074188
15	DMPK	1.10795029
16	MARK1	1.07986870
17	MOS	1.07328608
18	LIMK1	1.04433020
19	NEK1	0.99341690
20	EEF2K	0.95414884
21	CAMK2G	0.92206105
22	CCNB1	0.87898021
23	MAP2K6	0.87536644
24	PRKAA2	0.78958311
25	NEK9	0.74472026
26	MAP3K13	0.71766062
27	PRKAA1	0.70357365
28	DYRK1B	0.70154334
29	CAMK4	0.69524262
30	ERBB3	0.67174534
31	PIK3CA	0.66543794
32	PDK2	0.66138514
33	MAPK7	0.61829242
34	AKT2	0.61537380
35	RIPK1	0.59051269
36	BCKDK	0.58340940
37	CAMK2D	0.57675626
38	TRIB3	0.57290799
39	CAMK1	0.57235314
40	PRKG1	0.51913816
41	PKN1	0.50950752
42	MAPK11	0.50911447
43	MAP2K1	0.50897767
44	KSR2	0.49271611
45	MAPK4	0.48986479
46	CAMK2A	0.48464866
47	ROCK1	0.47180617
48	CAMK2B	0.45592753
49	SGK3	0.40824448
50	LATS2	0.36406624
51	ICK	0.34986510
52	PRKACA	0.32071608
53	RPS6KB2	0.32031706
54	TIE1	0.32023125
55	GRK7	0.29888702
56	TBK1	0.28622273
57	SGK2	0.27552300
58	RPS6KA3	0.26688446
59	RPS6KB1	0.23166582
60	MAP3K1	0.22996753
61	SGK1	0.22938850
62	MAPK10	0.22733293
63	PRKACB	0.22644647
64	PRKD1	0.22518447
65	ARAF	0.20567281
66	TAOK2	0.20552602
67	MAPK13	0.19666012
68	MARK2	0.19484510
69	EPHB1	0.19285946
70	SIK1	0.18312235
71	MYLK	0.18186619
72	PRPF4B	0.16650501
73	RPS6KA1	0.16075315
74	RPS6KC1	0.15489196
75	RPS6KL1	0.15489196
76	PRKACG	0.15073940
77	PDPK1	0.15070627
78	MAP3K10	0.14687030
79	DAPK2	0.14279401
80	MAP3K11	0.13836233
81	RAF1	0.13212448
82	MTOR	0.12403265
83	PTK2B	0.11835453
84	RPS6KA6	0.11517946
85	SGK223	0.10550623
86	SGK494	0.10550623
87	STK11	0.10496726
88	CDC42BPA	0.10338847
89	PDK1	0.10152934
90	LATS1	0.10061837
91	MAP3K6	0.08925463
92	ZAP70	0.08559173
93	MARK3	0.08186243
94	MAP3K5	0.08002854
95	KSR1	0.07693568
96	MAP3K3	0.06933898
97	EPHA3	0.06120077
98	MAP3K9	0.05806028
99	BRAF	0.04705840
100	CDK19	0.04507798

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	4.80075752
2	Cardiac muscle contraction_Homo sapiens_hsa04260	4.58068260
3	Dilated cardiomyopathy_Homo sapiens_hsa05414	4.35933102
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	4.01488422
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	3.94153083
6	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	3.43262727
7	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	3.39192879
8	Circadian rhythm_Homo sapiens_hsa04710	2.52043967
9	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	2.39642738
10	Carbon metabolism_Homo sapiens_hsa01200	2.15452909
11	Glucagon signaling pathway_Homo sapiens_hsa04922	2.15401617
12	Arginine and proline metabolism_Homo sapiens_hsa00330	1.99785095
13	Insulin signaling pathway_Homo sapiens_hsa04910	1.94568878
14	Pentose phosphate pathway_Homo sapiens_hsa00030	1.92889932
15	Arginine biosynthesis_Homo sapiens_hsa00220	1.80967324
16	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.79502963
17	Calcium signaling pathway_Homo sapiens_hsa04020	1.76861991
18	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.68134308
19	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.65843944
20	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.60271181
21	Parkinsons disease_Homo sapiens_hsa05012	1.57286140
22	Insulin resistance_Homo sapiens_hsa04931	1.53820480
23	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	1.52006679
24	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.50929777
25	Pyruvate metabolism_Homo sapiens_hsa00620	1.50288727
26	Alzheimers disease_Homo sapiens_hsa05010	1.49238581
27	Propanoate metabolism_Homo sapiens_hsa00640	1.43355906
28	Fatty acid degradation_Homo sapiens_hsa00071	1.31250157
29	AMPK signaling pathway_Homo sapiens_hsa04152	1.24331430
30	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.21644737
31	Oxidative phosphorylation_Homo sapiens_hsa00190	1.20632617
32	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.18901399
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.18391012
34	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.12237857
35	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.11268688
36	Gastric acid secretion_Homo sapiens_hsa04971	1.03198442
37	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.02323732
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.01208006
39	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.99054476
40	Tight junction_Homo sapiens_hsa04530	0.96714400
41	Nitrogen metabolism_Homo sapiens_hsa00910	0.96673312
42	Phenylalanine metabolism_Homo sapiens_hsa00360	0.91417841
43	Viral myocarditis_Homo sapiens_hsa05416	0.89230021
44	Fatty acid metabolism_Homo sapiens_hsa01212	0.83101746
45	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.82585061
46	Renin secretion_Homo sapiens_hsa04924	0.80562104
47	Galactose metabolism_Homo sapiens_hsa00052	0.77008457
48	GnRH signaling pathway_Homo sapiens_hsa04912	0.75524200
49	Focal adhesion_Homo sapiens_hsa04510	0.73089383
50	Huntingtons disease_Homo sapiens_hsa05016	0.69961686
51	Long-term potentiation_Homo sapiens_hsa04720	0.67884108
52	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.64612244
53	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.64328780
54	Insulin secretion_Homo sapiens_hsa04911	0.61381102
55	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	0.53508642
56	FoxO signaling pathway_Homo sapiens_hsa04068	0.50100092
57	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.49935949
58	PPAR signaling pathway_Homo sapiens_hsa03320	0.49131718
59	Butanoate metabolism_Homo sapiens_hsa00650	0.45559199
60	beta-Alanine metabolism_Homo sapiens_hsa00410	0.45125766
61	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.44621836
62	Circadian entrainment_Homo sapiens_hsa04713	0.44169226
63	Salivary secretion_Homo sapiens_hsa04970	0.42963763
64	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.41740136
65	Fatty acid elongation_Homo sapiens_hsa00062	0.41032175
66	MAPK signaling pathway_Homo sapiens_hsa04010	0.39780276
67	Tryptophan metabolism_Homo sapiens_hsa00380	0.34590260
68	cAMP signaling pathway_Homo sapiens_hsa04024	0.34342374
69	Long-term depression_Homo sapiens_hsa04730	0.34249171
70	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.32178817
71	Regulation of actin cytoskeleton_Homo sapiens_hsa04810	0.31605902
72	Peroxisome_Homo sapiens_hsa04146	0.31599966
73	Cholinergic synapse_Homo sapiens_hsa04725	0.31182137
74	Lysine degradation_Homo sapiens_hsa00310	0.30836145
75	VEGF signaling pathway_Homo sapiens_hsa04370	0.28353249
76	Platelet activation_Homo sapiens_hsa04611	0.26192655
77	Amoebiasis_Homo sapiens_hsa05146	0.24200405
78	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.23333121
79	mTOR signaling pathway_Homo sapiens_hsa04150	0.22923509
80	Adherens junction_Homo sapiens_hsa04520	0.22872113
81	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.22635896
82	Pancreatic secretion_Homo sapiens_hsa04972	0.22035163
83	HIF-1 signaling pathway_Homo sapiens_hsa04066	0.21721674
84	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.21039842
85	Regulation of autophagy_Homo sapiens_hsa04140	0.20611847
86	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.20239186
87	Histidine metabolism_Homo sapiens_hsa00340	0.18856553
88	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.18815929
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.18526865
90	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.17557574
91	Glioma_Homo sapiens_hsa05214	0.16160370
92	Amphetamine addiction_Homo sapiens_hsa05031	0.15673144
93	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.14970614
94	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.14950686
95	Bile secretion_Homo sapiens_hsa04976	0.13642370
96	Melanogenesis_Homo sapiens_hsa04916	0.11575320
97	Purine metabolism_Homo sapiens_hsa00230	0.11363960
98	Thyroid cancer_Homo sapiens_hsa05216	0.09834270
99	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.08012025
100	ECM-receptor interaction_Homo sapiens_hsa04512	0.07323093

RPL7P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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