ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	8.53907922
2	positive regulation of microtubule polymerization (GO:0031116)	8.30976768
3	bundle of His cell to Purkinje myocyte communication (GO:0086069)	7.90005857
4	ovulation cycle (GO:0042698)	7.18717586
5	neutrophil mediated immunity (GO:0002446)	7.03532391
6	serotonin metabolic process (GO:0042428)	6.75507057
7	positive regulation of microtubule polymerization or depolymerization (GO:0031112)	6.53570521
8	positive regulation of granulocyte differentiation (GO:0030854)	6.42354398
9	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	6.41377169
10	regulation of translational elongation (GO:0006448)	6.04888254
11	primary amino compound metabolic process (GO:1901160)	5.93890358
12	protein ADP-ribosylation (GO:0006471)	5.70084310
13	neural tube formation (GO:0001841)	5.48708514
14	nodal signaling pathway (GO:0038092)	5.15701712
15	signal transduction involved in regulation of gene expression (GO:0023019)	5.07161046
16	myeloid leukocyte mediated immunity (GO:0002444)	5.04647585
17	I-kappaB phosphorylation (GO:0007252)	4.92405085
18	microtubule nucleation (GO:0007020)	4.89787560
19	mating behavior (GO:0007617)	4.88309310
20	pattern specification involved in kidney development (GO:0061004)	4.84381892
21	histone H4-K12 acetylation (GO:0043983)	4.77690039
22	cranial nerve development (GO:0021545)	4.75957224
23	cytoplasmic microtubule organization (GO:0031122)	4.43163433
24	neuronal action potential (GO:0019228)	4.40249191
25	urinary tract smooth muscle contraction (GO:0014848)	4.28525480
26	NLS-bearing protein import into nucleus (GO:0006607)	4.27439072
27	positive regulation of T cell cytokine production (GO:0002726)	4.25216575
28	negative regulation of cytosolic calcium ion concentration (GO:0051481)	4.21510166
29	somite development (GO:0061053)	4.17704555
30	oligosaccharide catabolic process (GO:0009313)	4.10761808
31	sulfation (GO:0051923)	4.08803811
32	regulation of pigment cell differentiation (GO:0050932)	4.08767060
33	regulation of neuron migration (GO:2001222)	4.08404002
34	cellular response to exogenous dsRNA (GO:0071360)	4.07246354
35	behavioral response to nicotine (GO:0035095)	4.06024293
36	forebrain neuron differentiation (GO:0021879)	3.87096172
37	cellular potassium ion homeostasis (GO:0030007)	3.78304395
38	chondrocyte proliferation (GO:0035988)	3.76718298
39	positive regulation of developmental pigmentation (GO:0048087)	3.76049217
40	opioid receptor signaling pathway (GO:0038003)	3.69809190
41	chromatin silencing (GO:0006342)	3.67834292
42	indole-containing compound metabolic process (GO:0042430)	3.64105026
43	response to dietary excess (GO:0002021)	3.61704410
44	negative regulation of telomere maintenance (GO:0032205)	3.60255698
45	mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)	3.53042442
46	neutrophil activation (GO:0042119)	3.52827933
47	negative regulation of cAMP-mediated signaling (GO:0043951)	3.52152730
48	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.51655639
49	regulation of granulocyte differentiation (GO:0030852)	3.50360257
50	maturation of 5.8S rRNA (GO:0000460)	3.49778383
51	regulation of establishment of cell polarity (GO:2000114)	3.49250835
52	epithelial cilium movement (GO:0003351)	3.43528173
53	flavonoid metabolic process (GO:0009812)	3.40995238
54	lens fiber cell differentiation (GO:0070306)	3.39933570
55	negative regulation of mast cell activation (GO:0033004)	3.37071364
56	dorsal/ventral neural tube patterning (GO:0021904)	3.34368252
57	mitochondrial genome maintenance (GO:0000002)	3.33380841
58	cilium or flagellum-dependent cell motility (GO:0001539)	3.25347711
59	regulation of microtubule polymerization (GO:0031113)	3.23863677
60	activin receptor signaling pathway (GO:0032924)	3.18823367
61	embryonic epithelial tube formation (GO:0001838)	3.18498668
62	regulation of somitogenesis (GO:0014807)	3.18425061
63	glycerophospholipid catabolic process (GO:0046475)	3.14712219
64	type B pancreatic cell development (GO:0003323)	3.13010759
65	cytoplasmic mRNA processing body assembly (GO:0033962)	3.12012920
66	phenylpropanoid metabolic process (GO:0009698)	3.10039756
67	cellular response to dsRNA (GO:0071359)	3.09784267
68	regulation of T cell cytokine production (GO:0002724)	3.09584499
69	vesicle transport along microtubule (GO:0047496)	3.07527676
70	detection of temperature stimulus (GO:0016048)	3.07346748
71	granulocyte activation (GO:0036230)	3.05819034
72	cilium movement (GO:0003341)	3.04124347
73	epithelial tube formation (GO:0072175)	3.01125323
74	axonemal dynein complex assembly (GO:0070286)	3.00502461
75	entrainment of circadian clock (GO:0009649)	2.97628730
76	RNA destabilization (GO:0050779)	2.93639135
77	rRNA catabolic process (GO:0016075)	2.93318906
78	acrosome assembly (GO:0001675)	2.90086515
79	startle response (GO:0001964)	2.88512600
80	receptor guanylyl cyclase signaling pathway (GO:0007168)	2.85381469
81	negative regulation of gene expression, epigenetic (GO:0045814)	2.85133523
82	ubiquinone biosynthetic process (GO:0006744)	2.84268008
83	lens morphogenesis in camera-type eye (GO:0002089)	2.84191826
84	interferon-gamma secretion (GO:0072643)	2.83054725
85	circadian sleep/wake cycle process (GO:0022410)	2.81798171
86	negative regulation of necroptotic process (GO:0060546)	2.80221840
87	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.76356576
88	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.74902156
89	kidney morphogenesis (GO:0060993)	2.74451873
90	membrane depolarization during action potential (GO:0086010)	2.74059137
91	activation of NF-kappaB-inducing kinase activity (GO:0007250)	2.73474796
92	astrocyte differentiation (GO:0048708)	2.73260278
93	behavioral response to ethanol (GO:0048149)	2.72736498
94	regulation of energy homeostasis (GO:2000505)	2.71551428
95	cardiac muscle cell proliferation (GO:0060038)	2.70781211
96	polyketide metabolic process (GO:0030638)	2.69039115
97	doxorubicin metabolic process (GO:0044598)	2.69039115
98	daunorubicin metabolic process (GO:0044597)	2.69039115
99	segment specification (GO:0007379)	2.68471537
100	regulation of translational fidelity (GO:0006450)	10.0422419

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_22108803_ChIP-Seq_LS180_Human	3.95901317
2	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	3.75080247
3	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	3.71090757
4	EZH2_22144423_ChIP-Seq_EOC_Human	3.16571629
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.05761257
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.89608637
7	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.71420866
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.69293829
9	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.45110595
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31933602
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.20605407
12	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.18770976
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.15416410
14	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	2.12161752
15	EWS_26573619_Chip-Seq_HEK293_Human	1.99665632
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.95753987
17	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.95753987
18	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.92158446
19	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.88410945
20	AR_21572438_ChIP-Seq_LNCaP_Human	1.87556072
21	P300_19829295_ChIP-Seq_ESCs_Human	1.83177992
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.79133643
23	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75038206
24	RUNX2_22187159_ChIP-Seq_PCA_Human	1.74913107
25	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.73463620
26	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.73463620
27	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.72512299
28	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.72332142
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.71418903
30	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.70459546
31	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.69901061
32	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.68315457
33	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.65964909
34	AR_25329375_ChIP-Seq_VCAP_Human	1.62088196
35	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.60296960
36	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.59649784
37	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.58907661
38	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.57352170
39	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56326983
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.55364661
41	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.51421645
42	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.49836192
43	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.46264652
44	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42352227
45	MYC_18940864_ChIP-ChIP_HL60_Human	1.40528896
46	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.40230199
47	ER_23166858_ChIP-Seq_MCF-7_Human	1.38267090
48	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.36914593
49	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.35074613
50	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34905086
51	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.34464715
52	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.34464715
53	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.34464715
54	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.33610193
55	GATA3_26560356_Chip-Seq_TH1_Human	1.33558708
56	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.33220940
57	REST_21632747_ChIP-Seq_MESCs_Mouse	1.31828331
58	FUS_26573619_Chip-Seq_HEK293_Human	1.30717209
59	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.30650428
60	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.29718674
61	SMAD4_21799915_ChIP-Seq_A2780_Human	1.28171381
62	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.27701315
63	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.25263719
64	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.23610419
65	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.23330199
66	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.22984924
67	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.22614582
68	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.20796376
69	AR_20517297_ChIP-Seq_VCAP_Human	1.20791156
70	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20332783
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.15555328
72	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.14743800
73	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.14009711
74	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.13325245
75	TCF4_23295773_ChIP-Seq_U87_Human	1.13011840
76	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.12775087
77	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10497723
78	TCF4_22108803_ChIP-Seq_LS180_Human	1.09683007
79	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.09331543
80	JUN_21703547_ChIP-Seq_K562_Human	1.09018173
81	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.07473482
82	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.07253820
83	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.07253820
84	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.03079438
85	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.01853430
86	STAT3_23295773_ChIP-Seq_U87_Human	1.01105752
87	NCOR_22424771_ChIP-Seq_293T_Human	1.01066061
88	SOX2_19829295_ChIP-Seq_ESCs_Human	1.00518076
89	NANOG_19829295_ChIP-Seq_ESCs_Human	1.00518076
90	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.00305319
91	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00186386
92	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.00092998
93	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.99255073
94	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.97919080
95	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.97684165
96	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.96913826
97	TBL1_22424771_ChIP-Seq_293T_Human	0.96721303
98	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.96203725
99	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95760450
100	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.95730988

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.45556876
2	MP0005187_abnormal_penis_morphology	4.45384242
3	MP0002736_abnormal_nociception_after	4.14544102
4	MP0003315_abnormal_perineum_morphology	3.68098098
5	MP0001968_abnormal_touch/_nociception	3.63682014
6	MP0010386_abnormal_urinary_bladder	3.54459300
7	MP0008995_early_reproductive_senescence	3.24119983
8	MP0006292_abnormal_olfactory_placode	3.19734809
9	MP0002163_abnormal_gland_morphology	3.15583079
10	MP0002254_reproductive_system_inflammat	3.15103762
11	MP0000427_abnormal_hair_cycle	3.10886414
12	MP0001346_abnormal_lacrimal_gland	2.87463876
13	MP0003300_gastrointestinal_ulcer	2.57264323
14	MP0005379_endocrine/exocrine_gland_phen	2.39892842
15	MP0001873_stomach_inflammation	2.32991623
16	MP0004133_heterotaxia	2.29360424
17	MP0009053_abnormal_anal_canal	2.28612602
18	MP0000647_abnormal_sebaceous_gland	2.15697903
19	MP0003646_muscle_fatigue	2.13066665
20	MP0002009_preneoplasia	1.93459940
21	MP0002928_abnormal_bile_duct	1.89932449
22	MP0005645_abnormal_hypothalamus_physiol	1.88902804
23	MP0003195_calcinosis	1.80508218
24	MP0002733_abnormal_thermal_nociception	1.80123841
25	MP0000383_abnormal_hair_follicle	1.75105347
26	MP0002098_abnormal_vibrissa_morphology	1.72980498
27	MP0003252_abnormal_bile_duct	1.72498436
28	MP0000631_abnormal_neuroendocrine_gland	1.69033638
29	MP0003890_abnormal_embryonic-extraembry	1.62380060
30	MP0003879_abnormal_hair_cell	1.59967009
31	MP0002876_abnormal_thyroid_physiology	1.56200850
32	MP0002272_abnormal_nervous_system	1.54184173
33	MP0008877_abnormal_DNA_methylation	1.54043358
34	MP0009384_cardiac_valve_regurgitation	1.50830953
35	MP0004134_abnormal_chest_morphology	1.45662016
36	MP0001664_abnormal_digestion	1.44918154
37	MP0000569_abnormal_digit_pigmentation	1.43236929
38	MP0008875_abnormal_xenobiotic_pharmacok	1.41856670
39	MP0001348_abnormal_lacrimal_gland	1.36476773
40	MP0009745_abnormal_behavioral_response	1.32086260
41	MP0003567_abnormal_fetal_cardiomyocyte	1.31480282
42	MP0001293_anophthalmia	1.30763629
43	MP0009046_muscle_twitch	1.22252490
44	MP0005310_abnormal_salivary_gland	1.17063349
45	MP0001299_abnormal_eye_distance/	1.15358644
46	MP0003959_abnormal_lean_body	1.14626409
47	MP0001756_abnormal_urination	1.14507205
48	MP0005058_abnormal_lysosome_morphology	1.12909307
49	MP0002638_abnormal_pupillary_reflex	1.11180299
50	MP0000685_abnormal_immune_system	1.07489606
51	MP0003787_abnormal_imprinting	1.03855396
52	MP0000372_irregular_coat_pigmentation	1.03597933
53	MP0002102_abnormal_ear_morphology	1.01597245
54	MP0004142_abnormal_muscle_tone	0.97749013
55	MP0001970_abnormal_pain_threshold	0.97308297
56	MP0009250_abnormal_appendicular_skeleto	0.97258444
57	MP0002735_abnormal_chemical_nociception	0.96081294
58	MP0005646_abnormal_pituitary_gland	0.95940126
59	MP0003866_abnormal_defecation	0.95100826
60	MP0002067_abnormal_sensory_capabilities	0.94710718
61	MP0004043_abnormal_pH_regulation	0.94129889
62	MP0010678_abnormal_skin_adnexa	0.93412573
63	MP0003868_abnormal_feces_composition	0.88710845
64	MP0002233_abnormal_nose_morphology	0.88214993
65	MP0002160_abnormal_reproductive_system	0.87298443
66	MP0003786_premature_aging	0.84868042
67	MP0002132_abnormal_respiratory_system	0.83258918
68	MP0001765_abnormal_ion_homeostasis	0.81509779
69	MP0002064_seizures	0.73863010
70	MP0002148_abnormal_hypersensitivity_rea	0.72973345
71	MP0003937_abnormal_limbs/digits/tail_de	0.71167228
72	MP0002277_abnormal_respiratory_mucosa	0.70760154
73	MP0005535_abnormal_body_temperature	0.70614843
74	MP0001501_abnormal_sleep_pattern	0.67534461
75	MP0003880_abnormal_central_pattern	0.67122062
76	MP0002837_dystrophic_cardiac_calcinosis	0.66840982
77	MP0004381_abnormal_hair_follicle	0.66767213
78	MP0002109_abnormal_limb_morphology	0.65711583
79	MP0000566_synostosis	0.65676625
80	MP0005332_abnormal_amino_acid	0.65630329
81	MP0002063_abnormal_learning/memory/cond	0.65189318
82	MP0002092_abnormal_eye_morphology	0.64942110
83	MP0000778_abnormal_nervous_system	0.64933160
84	MP0001905_abnormal_dopamine_level	0.64770303
85	MP0001663_abnormal_digestive_system	0.62933429
86	MP0010329_abnormal_lipoprotein_level	0.61246077
87	MP0004742_abnormal_vestibular_system	0.60249849
88	MP0005647_abnormal_sex_gland	0.59618532
89	MP0002693_abnormal_pancreas_physiology	0.59112395
90	MP0001944_abnormal_pancreas_morphology	0.58997119
91	MP0000613_abnormal_salivary_gland	0.57090294
92	MP0003137_abnormal_impulse_conducting	0.56920724
93	MP0002557_abnormal_social/conspecific_i	0.56606227
94	MP0004130_abnormal_muscle_cell	0.56071467
95	MP0001286_abnormal_eye_development	0.55762343
96	MP0002909_abnormal_adrenal_gland	0.55210763
97	MP0003698_abnormal_male_reproductive	0.55049930
98	MP0002210_abnormal_sex_determination	0.53875183
99	MP0002115_abnormal_skeleton_extremities	0.53863546
100	MP0004885_abnormal_endolymph	0.53675861

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Premature ovarian failure (HP:0008209)	6.68008505
2	Progressive hearing impairment (HP:0001730)	6.66805184
3	Tubular atrophy (HP:0000092)	5.39210820
4	Secondary amenorrhea (HP:0000869)	5.38269944
5	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	5.00757034
6	Abnormality of alanine metabolism (HP:0010916)	5.00757034
7	Hyperalaninemia (HP:0003348)	5.00757034
8	Tubulointerstitial fibrosis (HP:0005576)	4.58076197
9	Osteomalacia (HP:0002749)	4.57049774
10	Thin bony cortex (HP:0002753)	3.97918107
11	Megalencephaly (HP:0001355)	3.90809261
12	Spastic tetraparesis (HP:0001285)	3.49143725
13	Intestinal atresia (HP:0011100)	3.48244056
14	Delayed epiphyseal ossification (HP:0002663)	3.43928748
15	Enlarged epiphyses (HP:0010580)	3.32631755
16	Cupped ear (HP:0000378)	3.27922930
17	Molar tooth sign on MRI (HP:0002419)	3.22322008
18	Abnormality of midbrain morphology (HP:0002418)	3.22322008
19	Rectal prolapse (HP:0002035)	3.19710316
20	Oculomotor apraxia (HP:0000657)	3.18898205
21	Genetic anticipation (HP:0003743)	3.14291299
22	Thickened helices (HP:0000391)	3.13335524
23	Gastrointestinal atresia (HP:0002589)	3.11183958
24	Hematochezia (HP:0002573)	3.00225689
25	Global brain atrophy (HP:0002283)	2.97126132
26	Wrist flexion contracture (HP:0001239)	2.87918498
27	Type I diabetes mellitus (HP:0100651)	2.81516132
28	Increased serum pyruvate (HP:0003542)	2.80759881
29	Submucous cleft hard palate (HP:0000176)	2.76928177
30	Abnormality of the columella (HP:0009929)	2.72733143
31	Progressive inability to walk (HP:0002505)	2.71322878
32	Adrenal hypoplasia (HP:0000835)	2.70278388
33	Hypophosphatemic rickets (HP:0004912)	2.60261505
34	Stomatitis (HP:0010280)	2.59370430
35	2-3 toe syndactyly (HP:0004691)	2.57571596
36	Tubulointerstitial abnormality (HP:0001969)	2.57103920
37	Conical tooth (HP:0000698)	2.56795782
38	Concave nail (HP:0001598)	2.50898100
39	Abnormal respiratory motile cilium morphology (HP:0005938)	2.48252902
40	Abnormal respiratory epithelium morphology (HP:0012253)	2.48252902
41	Optic disc pallor (HP:0000543)	2.46879256
42	Proximal tubulopathy (HP:0000114)	2.46444354
43	Partial agenesis of the corpus callosum (HP:0001338)	2.46104610
44	Asplenia (HP:0001746)	2.42499831
45	Pancreatic cysts (HP:0001737)	2.39934133
46	Large for gestational age (HP:0001520)	2.38382890
47	Abnormal ciliary motility (HP:0012262)	2.36591694
48	Partial duplication of thumb phalanx (HP:0009944)	2.36047237
49	Epidermoid cyst (HP:0200040)	2.33687650
50	Nonprogressive disorder (HP:0003680)	2.32951533
51	Mesomelia (HP:0003027)	2.32393968
52	Absent hair (HP:0002298)	2.29856861
53	Nephronophthisis (HP:0000090)	2.28849600
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.27950658
55	Pancreatic fibrosis (HP:0100732)	2.26754868
56	Abnormality of the renal cortex (HP:0011035)	2.25757382
57	Cutaneous finger syndactyly (HP:0010554)	2.25605498
58	Abnormality of glycolysis (HP:0004366)	2.23344132
59	Morphological abnormality of the pyramidal tract (HP:0002062)	2.20384953
60	Split foot (HP:0001839)	2.20138959
61	Absent eyebrow (HP:0002223)	2.19770724
62	Abnormality of secondary sexual hair (HP:0009888)	2.19035476
63	Abnormality of the axillary hair (HP:0100134)	2.19035476
64	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.18498628
65	Long eyelashes (HP:0000527)	2.16412848
66	Absent/shortened dynein arms (HP:0200106)	2.16040355
67	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.16040355
68	Prominent supraorbital ridges (HP:0000336)	2.13251068
69	Arthropathy (HP:0003040)	2.11938621
70	Urethral obstruction (HP:0000796)	2.11810382
71	Pustule (HP:0200039)	2.11186483
72	Abnormality of the renal medulla (HP:0100957)	2.09919811
73	Camptodactyly of toe (HP:0001836)	2.09840654
74	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.08640465
75	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.08640465
76	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.08121963
77	Urinary bladder sphincter dysfunction (HP:0002839)	2.07294089
78	Palpebral edema (HP:0100540)	2.03830978
79	Keratoconus (HP:0000563)	2.00170532
80	Increased corneal curvature (HP:0100692)	2.00170532
81	Congenital, generalized hypertrichosis (HP:0004540)	1.99008162
82	Metaphyseal irregularity (HP:0003025)	1.97622595
83	Polydipsia (HP:0001959)	1.96770413
84	Abnormal drinking behavior (HP:0030082)	1.96770413
85	Thick nail (HP:0001805)	1.95213881
86	Partial duplication of the phalanx of hand (HP:0009999)	1.94447341
87	Esophageal atresia (HP:0002032)	1.88463110
88	Cystic liver disease (HP:0006706)	1.87599427
89	Decreased central vision (HP:0007663)	1.85588323
90	Inability to walk (HP:0002540)	1.85577950
91	Abnormality of the ileum (HP:0001549)	1.82858372
92	True hermaphroditism (HP:0010459)	1.82766339
93	Trigonocephaly (HP:0000243)	1.81690889
94	Ulnar claw (HP:0001178)	1.81583484
95	Preaxial foot polydactyly (HP:0001841)	1.80455764
96	Xerostomia (HP:0000217)	1.79742764
97	Intellectual disability, progressive (HP:0006887)	1.78918178
98	Abnormal respiratory motile cilium physiology (HP:0012261)	1.77741288
99	Vacuolated lymphocytes (HP:0001922)	1.75282564
100	Cutaneous syndactyly (HP:0012725)	1.74535309

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	9.45189634
2	ICK	4.34948616
3	IRAK1	4.07559990
4	IRAK2	3.54254370
5	ACVR1B	3.19313736
6	CDK8	3.17541283
7	ADRBK2	3.15094383
8	NUAK1	3.10508261
9	RPS6KA4	2.79037409
10	MAP3K7	2.66210269
11	EPHA3	2.43863988
12	DMPK	2.27258835
13	BMPR1B	2.08210834
14	CDK3	1.90655086
15	FGFR3	1.66287504
16	ILK	1.58977732
17	PLK2	1.55169645
18	CASK	1.32334162
19	ZAK	1.29481617
20	PINK1	1.25625143
21	GRK1	1.23821985
22	DAPK2	1.20749040
23	TGFBR1	1.03296090
24	PTK6	0.97309363
25	ADRBK1	0.91069620
26	MAPK15	0.90790092
27	PNCK	0.88829691
28	RAF1	0.87858902
29	AKT3	0.86821284
30	VRK1	0.86700134
31	TAOK3	0.78592405
32	PRKCG	0.77755503
33	CDK7	0.74118851
34	CAMK1	0.72898857
35	RPS6KA5	0.72567597
36	CDK6	0.72284476
37	FGFR1	0.71061793
38	PRKCQ	0.70870732
39	CAMK2A	0.63616711
40	PRKCE	0.62010622
41	MELK	0.59997117
42	PRKD3	0.59578267
43	BCR	0.58601742
44	PRKAA1	0.58417400
45	PDGFRB	0.56606364
46	BRSK2	0.56214273
47	TEC	0.52508437
48	MARK2	0.50550806
49	ITK	0.49357012
50	CDK4	0.48444722
51	YES1	0.47977001
52	MKNK2	0.45380095
53	NEK6	0.43993629
54	CSNK1G2	0.43710126
55	STK11	0.41742652
56	TLK1	0.41728925
57	RPS6KA6	0.40101082
58	WEE1	0.39588735
59	IKBKB	0.36037174
60	CAMK2G	0.34593109
61	PTK2B	0.34547990
62	PKN1	0.34516768
63	TRIM28	0.33477873
64	MAPK13	0.32431085
65	PRKG1	0.32319407
66	MAP2K6	0.32119384
67	BTK	0.32032667
68	UHMK1	0.30619460
69	TYRO3	0.29930993
70	PRKCZ	0.28730815
71	INSRR	0.28597046
72	PDK1	0.27985653
73	PRKACB	0.27971342
74	PRKACA	0.27455587
75	MAP3K13	0.26728361
76	CSNK1A1	0.25454354
77	MARK1	0.25201296
78	PRKCA	0.23723708
79	ERBB2	0.22745496
80	LYN	0.22638507
81	TXK	0.21627271
82	PDPK1	0.21612017
83	PRKCH	0.21213489
84	EPHA4	0.20540249
85	PRKAA2	0.20287009
86	NEK2	0.20146525
87	NEK1	0.19907950
88	NLK	0.18865860
89	PRKCD	0.18295849
90	CSNK1D	0.17980539
91	DAPK1	0.16092818
92	PIM1	0.15779939
93	RPS6KA3	0.14950167
94	BLK	0.14899868
95	ROCK1	0.14483013
96	KIT	0.13755187
97	MAP4K2	0.13709171
98	MAP2K1	0.12949582
99	PLK3	0.11999221
100	CSNK1E	0.11654632

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Linoleic acid metabolism_Homo sapiens_hsa00591	3.09347733
2	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	2.94151321
3	Olfactory transduction_Homo sapiens_hsa04740	2.90687859
4	Cardiac muscle contraction_Homo sapiens_hsa04260	2.88416992
5	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.61214473
6	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.55127358
7	Butanoate metabolism_Homo sapiens_hsa00650	2.42507278
8	Ether lipid metabolism_Homo sapiens_hsa00565	2.35641927
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.18976541
10	Melanoma_Homo sapiens_hsa05218	2.13337432
11	Phototransduction_Homo sapiens_hsa04744	2.08846352
12	Nicotine addiction_Homo sapiens_hsa05033	1.90054480
13	Protein export_Homo sapiens_hsa03060	1.83354724
14	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.79162719
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.76383279
16	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.71509345
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70183833
18	Steroid biosynthesis_Homo sapiens_hsa00100	1.64898640
19	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.62921383
20	Oxidative phosphorylation_Homo sapiens_hsa00190	1.57414027
21	Caffeine metabolism_Homo sapiens_hsa00232	1.57352092
22	Lysine degradation_Homo sapiens_hsa00310	1.51048058
23	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.48069483
24	Primary immunodeficiency_Homo sapiens_hsa05340	1.45759522
25	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.43292649
26	Glutamatergic synapse_Homo sapiens_hsa04724	1.38729094
27	Taste transduction_Homo sapiens_hsa04742	1.32389753
28	Parkinsons disease_Homo sapiens_hsa05012	1.27382549
29	Alzheimers disease_Homo sapiens_hsa05010	1.25258001
30	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.25252283
31	MAPK signaling pathway_Homo sapiens_hsa04010	1.24393528
32	Asthma_Homo sapiens_hsa05310	1.24063466
33	Insulin secretion_Homo sapiens_hsa04911	1.22371275
34	Sulfur relay system_Homo sapiens_hsa04122	1.17405086
35	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.15565220
36	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.15468555
37	T cell receptor signaling pathway_Homo sapiens_hsa04660	1.10747040
38	Pyruvate metabolism_Homo sapiens_hsa00620	1.07203830
39	Measles_Homo sapiens_hsa05162	1.05425299
40	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	1.03560303
41	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.97724287
42	RNA degradation_Homo sapiens_hsa03018	0.97156797
43	Renin secretion_Homo sapiens_hsa04924	0.92600017
44	ABC transporters_Homo sapiens_hsa02010	0.91683874
45	Circadian entrainment_Homo sapiens_hsa04713	0.89555108
46	Allograft rejection_Homo sapiens_hsa05330	0.87706578
47	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.86369974
48	cAMP signaling pathway_Homo sapiens_hsa04024	0.85652443
49	Peroxisome_Homo sapiens_hsa04146	0.84222735
50	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.83503606
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82812846
52	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.81469849
53	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.79835413
54	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.79167491
55	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.76428007
56	Sulfur metabolism_Homo sapiens_hsa00920	0.75324278
57	Huntingtons disease_Homo sapiens_hsa05016	0.74652095
58	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.74597167
59	Basal transcription factors_Homo sapiens_hsa03022	0.74482936
60	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73867524
61	Long-term depression_Homo sapiens_hsa04730	0.73625599
62	Type I diabetes mellitus_Homo sapiens_hsa04940	0.73148046
63	Dopaminergic synapse_Homo sapiens_hsa04728	0.72328584
64	Folate biosynthesis_Homo sapiens_hsa00790	0.70722073
65	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.69545735
66	Selenocompound metabolism_Homo sapiens_hsa00450	0.68916796
67	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.67516729
68	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.67114361
69	Ras signaling pathway_Homo sapiens_hsa04014	0.65872448
70	Salivary secretion_Homo sapiens_hsa04970	0.65346238
71	Protein digestion and absorption_Homo sapiens_hsa04974	0.62259314
72	FoxO signaling pathway_Homo sapiens_hsa04068	0.60217314
73	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.58088538
74	Cocaine addiction_Homo sapiens_hsa05030	0.56520003
75	Graft-versus-host disease_Homo sapiens_hsa05332	0.55718069
76	Serotonergic synapse_Homo sapiens_hsa04726	0.53984748
77	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53497322
78	Calcium signaling pathway_Homo sapiens_hsa04020	0.53423626
79	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.52987021
80	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.51810126
81	TNF signaling pathway_Homo sapiens_hsa04668	0.49425614
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.49397240
83	ErbB signaling pathway_Homo sapiens_hsa04012	0.48724704
84	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.48192042
85	Hippo signaling pathway_Homo sapiens_hsa04390	0.47879680
86	Morphine addiction_Homo sapiens_hsa05032	0.47851894
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.46030495
88	Platelet activation_Homo sapiens_hsa04611	0.45641923
89	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.45117931
90	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44948327
91	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.43504030
92	Fanconi anemia pathway_Homo sapiens_hsa03460	0.43495911
93	Pancreatic secretion_Homo sapiens_hsa04972	0.42210646
94	beta-Alanine metabolism_Homo sapiens_hsa00410	0.42200145
95	Amphetamine addiction_Homo sapiens_hsa05031	0.41549444
96	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.41278382
97	AMPK signaling pathway_Homo sapiens_hsa04152	0.41261176
98	Renin-angiotensin system_Homo sapiens_hsa04614	0.41049438
99	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.40954933
100	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.38534715

RPL7P31

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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