ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.56703407
2	kynurenine metabolic process (GO:0070189)	4.39943044
3	ATP synthesis coupled proton transport (GO:0015986)	4.32132114
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.32132114
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.18365805
6	indole-containing compound catabolic process (GO:0042436)	4.12705144
7	indolalkylamine catabolic process (GO:0046218)	4.12705144
8	tryptophan catabolic process (GO:0006569)	4.12705144
9	tryptophan metabolic process (GO:0006568)	4.07875185
10	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	3.74164002
11	immunoglobulin mediated immune response (GO:0016064)	3.59028686
12	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.52984465
13	indolalkylamine metabolic process (GO:0006586)	3.40341136
14	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.29648274
15	electron transport chain (GO:0022900)	3.29455320
16	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.28899080
17	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.28899080
18	respiratory electron transport chain (GO:0022904)	3.28032538
19	B cell mediated immunity (GO:0019724)	3.27239718
20	cytidine catabolic process (GO:0006216)	3.19421306
21	cytidine deamination (GO:0009972)	3.19421306
22	cytidine metabolic process (GO:0046087)	3.19421306
23	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.18013635
24	protein complex biogenesis (GO:0070271)	3.14975936
25	fucose catabolic process (GO:0019317)	3.14120700
26	L-fucose metabolic process (GO:0042354)	3.14120700
27	L-fucose catabolic process (GO:0042355)	3.14120700
28	mast cell activation (GO:0045576)	3.09906663
29	protein neddylation (GO:0045116)	3.05698226
30	positive thymic T cell selection (GO:0045059)	3.05102573
31	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.02353932
32	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.99419168
33	negative regulation of mast cell activation (GO:0033004)	2.99041154
34	respiratory chain complex IV assembly (GO:0008535)	2.95261342
35	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.93302678
36	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.87965670
37	cytochrome complex assembly (GO:0017004)	2.87538311
38	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.87472771
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.86570806
40	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85563735
41	NADH dehydrogenase complex assembly (GO:0010257)	2.85563735
42	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85563735
43	piRNA metabolic process (GO:0034587)	2.84370812
44	positive regulation of prostaglandin secretion (GO:0032308)	2.82294830
45	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81288451
46	regulation of regulatory T cell differentiation (GO:0045589)	2.81107811
47	mast cell degranulation (GO:0043303)	2.80229356
48	mast cell activation involved in immune response (GO:0002279)	2.80229356
49	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.78077213
50	ribosomal small subunit assembly (GO:0000028)	2.76762059
51	proteasome assembly (GO:0043248)	2.74873567
52	regulation of isotype switching to IgG isotypes (GO:0048302)	2.70597472
53	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.70356732
54	aldehyde catabolic process (GO:0046185)	2.69948162
55	protein-cofactor linkage (GO:0018065)	2.69343524
56	positive regulation of T-helper 1 type immune response (GO:0002827)	2.69127501
57	response to interferon-beta (GO:0035456)	2.68794772
58	regulation of hypersensitivity (GO:0002883)	2.67911222
59	regulation of germinal center formation (GO:0002634)	2.66019933
60	negative regulation of heart rate (GO:0010459)	2.65155093
61	regulation of cellular amino acid metabolic process (GO:0006521)	2.64328625
62	regulation of T cell mediated cytotoxicity (GO:0001914)	2.62011107
63	maturation of 5.8S rRNA (GO:0000460)	2.61858242
64	GPI anchor metabolic process (GO:0006505)	2.60679519
65	GPI anchor biosynthetic process (GO:0006506)	2.59950559
66	hydrogen ion transmembrane transport (GO:1902600)	2.59895558
67	positive regulation of defense response to virus by host (GO:0002230)	2.59763297
68	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.59216654
69	mannosylation (GO:0097502)	2.57740578
70	proton transport (GO:0015992)	2.57320741
71	hydrogen transport (GO:0006818)	2.56764457
72	regulation of interleukin-8 secretion (GO:2000482)	2.56238160
73	ribosomal large subunit biogenesis (GO:0042273)	2.55239455
74	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.55106453
75	cellular biogenic amine catabolic process (GO:0042402)	2.54759661
76	amine catabolic process (GO:0009310)	2.54759661
77	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.54154437
78	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.53951730
79	positive regulation of protein homodimerization activity (GO:0090073)	2.53120609
80	chaperone-mediated protein transport (GO:0072321)	2.52756372
81	S-adenosylmethionine metabolic process (GO:0046500)	2.50887420
82	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.50502684
83	regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)	2.50434642
84	platelet dense granule organization (GO:0060155)	2.50133980
85	water-soluble vitamin biosynthetic process (GO:0042364)	2.49986939
86	regulation of B cell apoptotic process (GO:0002902)	2.49294128
87	regulation of antigen processing and presentation (GO:0002577)	2.47187841
88	GTP biosynthetic process (GO:0006183)	2.46931307
89	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.46448767
90	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.46436499
91	rRNA modification (GO:0000154)	2.46319649
92	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.46219736
93	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.46219736
94	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.46219736
95	cellular response to exogenous dsRNA (GO:0071360)	2.46095785
96	chaperone mediated protein folding requiring cofactor (GO:0051085)	2.44914622
97	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.42476292
98	behavioral response to nicotine (GO:0035095)	2.41886035
99	positive regulation of activated T cell proliferation (GO:0042104)	2.41275118
100	regulation of interleukin-1 beta secretion (GO:0050706)	2.41189114

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.38468418
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.86716947
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.20441805
4	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.20065008
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.14431353
6	VDR_22108803_ChIP-Seq_LS180_Human	2.92521901
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.92337365
8	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.86846330
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71950379
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.51146513
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.41158477
12	VDR_23849224_ChIP-Seq_CD4+_Human	2.40776164
13	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.38271012
14	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.21661456
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.19556164
16	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.11996892
17	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.09937631
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.06398923
19	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.95308392
20	GATA3_26560356_Chip-Seq_TH2_Human	1.91697945
21	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.90494187
22	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88395255
23	ELK1_19687146_ChIP-ChIP_HELA_Human	1.87514225
24	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.87485363
25	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.79331097
26	FOXP3_21729870_ChIP-Seq_TREG_Human	1.76822054
27	IGF1R_20145208_ChIP-Seq_DFB_Human	1.74691615
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.73691582
29	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61082696
30	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.55788971
31	IRF1_19129219_ChIP-ChIP_H3396_Human	1.55682752
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.55613996
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54747766
34	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.54524948
35	MYB_26560356_Chip-Seq_TH2_Human	1.53941133
36	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.52450793
37	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.52450793
38	AR_20517297_ChIP-Seq_VCAP_Human	1.49191134
39	MYC_18940864_ChIP-ChIP_HL60_Human	1.47780197
40	TAF15_26573619_Chip-Seq_HEK293_Human	1.46280516
41	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.45132985
42	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.44202704
43	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.42026256
44	EWS_26573619_Chip-Seq_HEK293_Human	1.41536297
45	ER_23166858_ChIP-Seq_MCF-7_Human	1.38209550
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.37563133
47	SOX2_19829295_ChIP-Seq_ESCs_Human	1.37563133
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31746911
49	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.28677675
50	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.27007407
51	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.25589354
52	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.25041797
53	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24351603
54	CBP_20019798_ChIP-Seq_JUKART_Human	1.24285048
55	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.24285048
56	FUS_26573619_Chip-Seq_HEK293_Human	1.23446022
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23002513
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.22821075
59	GATA3_27048872_Chip-Seq_THYMUS_Human	1.21167000
60	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21090971
61	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.21039925
62	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.20941703
63	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.19994596
64	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.19876819
65	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.19248655
66	TAF2_19829295_ChIP-Seq_ESCs_Human	1.19095391
67	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.19016404
68	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.17521840
69	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.15927382
70	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.14840462
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.13947729
72	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.13830061
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.13328757
74	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.12938713
75	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11343579
76	SPI1_23547873_ChIP-Seq_NB4_Human	1.10127729
77	ERG_20517297_ChIP-Seq_VCAP_Human	1.09407896
78	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.09008416
79	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08450112
80	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.06433859
81	RUNX_20019798_ChIP-Seq_JUKART_Human	1.05382520
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.05371972
83	P300_19829295_ChIP-Seq_ESCs_Human	1.04742955
84	NCOR_22424771_ChIP-Seq_293T_Human	1.04078384
85	MYC_19829295_ChIP-Seq_ESCs_Human	1.03980291
86	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.03709525
87	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.03337890
88	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.01036736
89	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	1.00626346
90	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99245412
91	GBX2_23144817_ChIP-Seq_PC3_Human	0.98873631
92	GATA3_26560356_Chip-Seq_TH1_Human	0.98463722
93	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.98066609
94	NANOG_20526341_ChIP-Seq_ESCs_Human	0.97701434
95	STAT1_20625510_ChIP-Seq_HELA_Human	0.97515127
96	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97339307
97	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.97114264
98	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.96287248
99	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.96236343
100	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.96145456

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.66369170
2	MP0005671_abnormal_response_to	3.61026906
3	MP0002138_abnormal_hepatobiliary_system	3.55352884
4	MP0008875_abnormal_xenobiotic_pharmacok	2.84983438
5	MP0002148_abnormal_hypersensitivity_rea	2.39610940
6	MP0006072_abnormal_retinal_apoptosis	2.35338690
7	MP0001800_abnormal_humoral_immune	2.35144096
8	MP0009785_altered_susceptibility_to	2.29396349
9	MP0003724_increased_susceptibility_to	2.26783342
10	MP0008872_abnormal_physiological_respon	2.17436686
11	MP0003806_abnormal_nucleotide_metabolis	2.14220691
12	MP0005000_abnormal_immune_tolerance	2.13364319
13	MP0000685_abnormal_immune_system	2.12789671
14	MP0004147_increased_porphyrin_level	1.99167342
15	MP0002166_altered_tumor_susceptibility	1.93591023
16	MP0002723_abnormal_immune_serum	1.85800961
17	MP0009764_decreased_sensitivity_to	1.84285464
18	MP0002876_abnormal_thyroid_physiology	1.82981962
19	MP0001968_abnormal_touch/_nociception	1.79523015
20	MP0002452_abnormal_antigen_presenting	1.79359874
21	MP0001986_abnormal_taste_sensitivity	1.79131503
22	MP0002006_tumorigenesis	1.79055120
23	MP0005387_immune_system_phenotype	1.74221600
24	MP0001790_abnormal_immune_system	1.74221600
25	MP0003866_abnormal_defecation	1.67909860
26	MP0002102_abnormal_ear_morphology	1.66338931
27	MP0005646_abnormal_pituitary_gland	1.66144295
28	MP0004145_abnormal_muscle_electrophysio	1.63583415
29	MP0001819_abnormal_immune_cell	1.59589197
30	MP0002420_abnormal_adaptive_immunity	1.58837927
31	MP0008877_abnormal_DNA_methylation	1.55980775
32	MP0002837_dystrophic_cardiac_calcinosis	1.55521911
33	MP0009333_abnormal_splenocyte_physiolog	1.52747102
34	MP0003646_muscle_fatigue	1.51171394
35	MP0005551_abnormal_eye_electrophysiolog	1.46041975
36	MP0005645_abnormal_hypothalamus_physiol	1.43227385
37	MP0010155_abnormal_intestine_physiology	1.42139015
38	MP0003436_decreased_susceptibility_to	1.37775776
39	MP0008775_abnormal_heart_ventricle	1.33066291
40	MP0003878_abnormal_ear_physiology	1.32438478
41	MP0005377_hearing/vestibular/ear_phenot	1.32438478
42	MP0006036_abnormal_mitochondrial_physio	1.31999260
43	MP0004142_abnormal_muscle_tone	1.31768812
44	MP0003195_calcinosis	1.31671094
45	MP0005084_abnormal_gallbladder_morpholo	1.31277017
46	MP0005025_abnormal_response_to	1.31042109
47	MP0006292_abnormal_olfactory_placode	1.30407647
48	MP0005075_abnormal_melanosome_morpholog	1.30372050
49	MP0003252_abnormal_bile_duct	1.29791747
50	MP0002736_abnormal_nociception_after	1.29466720
51	MP0001873_stomach_inflammation	1.28565497
52	MP0003011_delayed_dark_adaptation	1.28258413
53	MP0005253_abnormal_eye_physiology	1.25115577
54	MP0001845_abnormal_inflammatory_respons	1.24276102
55	MP0001501_abnormal_sleep_pattern	1.22447903
56	MP0003786_premature_aging	1.22169975
57	MP0002419_abnormal_innate_immunity	1.17091623
58	MP0001919_abnormal_reproductive_system	1.13953018
59	MP0003763_abnormal_thymus_physiology	1.13343826
60	MP0000716_abnormal_immune_system	1.13051555
61	MP0004885_abnormal_endolymph	1.12212934
62	MP0009379_abnormal_foot_pigmentation	1.10243778
63	MP0001905_abnormal_dopamine_level	1.09743726
64	MP0006082_CNS_inflammation	1.07725144
65	MP0000372_irregular_coat_pigmentation	1.07622052
66	MP0002398_abnormal_bone_marrow	1.07343561
67	MP0008995_early_reproductive_senescence	1.06836697
68	MP0005389_reproductive_system_phenotype	1.06009250
69	MP0000689_abnormal_spleen_morphology	1.00022797
70	MP0008469_abnormal_protein_level	0.97811754
71	MP0005167_abnormal_blood-brain_barrier	0.97180380
72	MP0005085_abnormal_gallbladder_physiolo	0.95533765
73	MP0000516_abnormal_urinary_system	0.95458482
74	MP0005367_renal/urinary_system_phenotyp	0.95458482
75	MP0005636_abnormal_mineral_homeostasis	0.94343260
76	MP0004043_abnormal_pH_regulation	0.94336076
77	MP0002272_abnormal_nervous_system	0.93993833
78	MP0003186_abnormal_redox_activity	0.92350810
79	MP0000230_abnormal_systemic_arterial	0.92115999
80	MP0001765_abnormal_ion_homeostasis	0.88016604
81	MP0002405_respiratory_system_inflammati	0.87896790
82	MP0003718_maternal_effect	0.87353512
83	MP0002429_abnormal_blood_cell	0.86212704
84	MP0006276_abnormal_autonomic_nervous	0.84236009
85	MP0005410_abnormal_fertilization	0.83331780
86	MP0002234_abnormal_pharynx_morphology	0.82450443
87	MP0009745_abnormal_behavioral_response	0.78567451
88	MP0003638_abnormal_response/metabolism_	0.78109877
89	MP0002722_abnormal_immune_system	0.77812601
90	MP0001970_abnormal_pain_threshold	0.76246918
91	MP0000427_abnormal_hair_cycle	0.75139052
92	MP0001533_abnormal_skeleton_physiology	0.74685207
93	MP0005360_urolithiasis	0.72445828
94	MP0009643_abnormal_urine_homeostasis	0.70947380
95	MP0008058_abnormal_DNA_repair	0.70153694
96	MP0001440_abnormal_grooming_behavior	0.70120876
97	MP0001486_abnormal_startle_reflex	0.68801650
98	MP0002733_abnormal_thermal_nociception	0.68691309
99	MP0005464_abnormal_platelet_physiology	0.67506933
100	MP0009046_muscle_twitch	0.65554407

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	3.82507358
2	Mitochondrial inheritance (HP:0001427)	3.81071534
3	3-Methylglutaconic aciduria (HP:0003535)	3.76718013
4	Hepatocellular necrosis (HP:0001404)	3.75171476
5	Acute necrotizing encephalopathy (HP:0006965)	3.58413975
6	Abnormality of the prostate (HP:0008775)	3.54292884
7	Increased CSF lactate (HP:0002490)	3.53329531
8	IgG deficiency (HP:0004315)	3.52662551
9	Congenital stationary night blindness (HP:0007642)	3.34361712
10	Hepatic necrosis (HP:0002605)	3.33402280
11	Pancreatic cysts (HP:0001737)	3.23980933
12	Acute encephalopathy (HP:0006846)	3.18465513
13	Elevated erythrocyte sedimentation rate (HP:0003565)	3.14862085
14	Abnormal mitochondria in muscle tissue (HP:0008316)	3.14848102
15	Progressive macrocephaly (HP:0004481)	3.14699106
16	Increased hepatocellular lipid droplets (HP:0006565)	3.14118021
17	Abolished electroretinogram (ERG) (HP:0000550)	3.13342634
18	Lipid accumulation in hepatocytes (HP:0006561)	3.06373869
19	Hypoproteinemia (HP:0003075)	3.04630352
20	Abnormality of B cell number (HP:0010975)	2.92734797
21	Panhypogammaglobulinemia (HP:0003139)	2.75810764
22	Stomatitis (HP:0010280)	2.74570514
23	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.65968662
24	Increased intramyocellular lipid droplets (HP:0012240)	2.63485844
25	Increased serum lactate (HP:0002151)	2.59147725
26	Stomach cancer (HP:0012126)	2.58686131
27	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.57130170
28	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.57130170
29	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.53977569
30	Abnormality of midbrain morphology (HP:0002418)	2.53232764
31	Molar tooth sign on MRI (HP:0002419)	2.53232764
32	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.50692925
33	Attenuation of retinal blood vessels (HP:0007843)	2.49859655
34	Abnormal rod and cone electroretinograms (HP:0008323)	2.45593939
35	Pancreatic fibrosis (HP:0100732)	2.44811135
36	Aplastic anemia (HP:0001915)	2.43653276
37	Severe combined immunodeficiency (HP:0004430)	2.43631140
38	Thyroiditis (HP:0100646)	2.42110420
39	Methylmalonic acidemia (HP:0002912)	2.40667206
40	Nephronophthisis (HP:0000090)	2.40202513
41	Agammaglobulinemia (HP:0004432)	2.39725292
42	Abnormality of the renal cortex (HP:0011035)	2.39080293
43	Exertional dyspnea (HP:0002875)	2.37246377
44	Optic disc pallor (HP:0000543)	2.37167028
45	Type II lissencephaly (HP:0007260)	2.36412715
46	Abnormality of T cell number (HP:0011839)	2.36178264
47	Lactic acidosis (HP:0003128)	2.36086536
48	Cerebral edema (HP:0002181)	2.35293744
49	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.34600153
50	Type 2 muscle fiber atrophy (HP:0003554)	2.32880523
51	Hypothermia (HP:0002045)	2.30544172
52	Prostate neoplasm (HP:0100787)	2.30099608
53	Abnormality of T cell physiology (HP:0011840)	2.27716906
54	Increased muscle lipid content (HP:0009058)	2.27383987
55	Decreased central vision (HP:0007663)	2.27277619
56	Abnormality of T cells (HP:0002843)	2.23893528
57	B lymphocytopenia (HP:0010976)	2.23556276
58	Optic neuritis (HP:0100653)	2.23455798
59	Retrobulbar optic neuritis (HP:0100654)	2.23455798
60	Renal Fanconi syndrome (HP:0001994)	2.21767088
61	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.21485038
62	Eosinophilia (HP:0001880)	2.21431140
63	Abnormality of the renal medulla (HP:0100957)	2.19401777
64	Myositis (HP:0100614)	2.15908194
65	Aplasia/hypoplasia of the uterus (HP:0008684)	2.15691839
66	Abnormality of eosinophils (HP:0001879)	2.14701890
67	True hermaphroditism (HP:0010459)	2.13480748
68	Renal cortical cysts (HP:0000803)	2.11339149
69	Keratoconus (HP:0000563)	2.11183548
70	Increased corneal curvature (HP:0100692)	2.11183548
71	T lymphocytopenia (HP:0005403)	2.10634545
72	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.10208201
73	Absent/shortened dynein arms (HP:0200106)	2.07600715
74	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.07600715
75	Delayed CNS myelination (HP:0002188)	2.07528420
76	Hemoptysis (HP:0002105)	2.06941110
77	Abnormality of male internal genitalia (HP:0000022)	2.05191675
78	Bile duct proliferation (HP:0001408)	2.03628894
79	Abnormal biliary tract physiology (HP:0012439)	2.03628894
80	Increased IgM level (HP:0003496)	2.01468756
81	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.97033868
82	Methylmalonic aciduria (HP:0012120)	1.95554293
83	Respiratory failure (HP:0002878)	1.95096905
84	Hypoplasia of the uterus (HP:0000013)	1.94620623
85	Pulmonary infiltrates (HP:0002113)	1.93601520
86	Polydipsia (HP:0001959)	1.92229620
87	Abnormal drinking behavior (HP:0030082)	1.92229620
88	Constricted visual fields (HP:0001133)	1.90837521
89	Encephalitis (HP:0002383)	1.90085676
90	Chronic diarrhea (HP:0002028)	1.89939887
91	Testicular atrophy (HP:0000029)	1.87395766
92	Autoimmune thrombocytopenia (HP:0001973)	1.86973671
93	Muscle fiber atrophy (HP:0100295)	1.86330865
94	Meningitis (HP:0001287)	1.85653213
95	Fibular aplasia (HP:0002990)	1.85178710
96	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.84809568
97	Abnormality of the pleura (HP:0002103)	1.84425646
98	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.82340319
99	Facial diplegia (HP:0001349)	1.79871940
100	Cerebral palsy (HP:0100021)	1.78999047

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TLK1	3.84259773
2	TXK	3.57461122
3	TAOK3	3.17559203
4	ZAK	3.03018272
5	MAP4K2	2.90600367
6	FRK	2.82886810
7	NUAK1	2.57674148
8	GRK1	2.35231728
9	BMPR1B	2.27818125
10	ADRBK2	2.25482371
11	BMPR2	2.22209381
12	WNK4	2.10611704
13	EIF2AK3	2.00334209
14	KIT	1.92964528
15	CDK19	1.91396065
16	STK16	1.84247441
17	BCKDK	1.71926267
18	MAP3K12	1.70032127
19	TEC	1.68446032
20	TIE1	1.58909762
21	ITK	1.53294464
22	OXSR1	1.50061950
23	SCYL2	1.47405330
24	MAP4K1	1.46347480
25	MAPKAPK3	1.44589394
26	PINK1	1.44281275
27	CDK8	1.44114237
28	CSF1R	1.40549040
29	FLT3	1.39749951
30	IKBKB	1.38901218
31	SYK	1.38418131
32	MST4	1.37935431
33	GRK6	1.37085425
34	MAP3K14	1.36153703
35	VRK2	1.32778831
36	ERBB3	1.32463880
37	FES	1.28326233
38	TRPM7	1.18634996
39	PHKG1	1.13449065
40	PHKG2	1.13449065
41	KDR	1.12860922
42	MYLK	1.10595428
43	BTK	0.98289716
44	DAPK1	0.97508357
45	VRK1	0.93850037
46	RIPK4	0.91997753
47	LYN	0.90818082
48	INSRR	0.89863335
49	JAK3	0.89571285
50	SRPK1	0.88005379
51	RPS6KA5	0.86961337
52	PLK2	0.86588769
53	TGFBR1	0.85243271
54	LCK	0.82415826
55	MAPKAPK5	0.79947143
56	CSNK1G3	0.79859796
57	STK39	0.77579120
58	WNK3	0.77029978
59	DAPK2	0.76081669
60	EIF2AK2	0.73120990
61	PRKCQ	0.68490451
62	PIK3CG	0.68214731
63	MKNK1	0.67981087
64	IKBKE	0.65575024
65	PIK3CA	0.64150280
66	MAP3K13	0.63113230
67	IGF1R	0.62256915
68	CSNK1A1L	0.61800332
69	MAP2K6	0.58981979
70	CSNK1G2	0.58237279
71	MAP2K2	0.56753862
72	ADRBK1	0.55209291
73	MAPK13	0.51794784
74	ACVR1B	0.51790509
75	PRKCE	0.50579968
76	GRK7	0.50345545
77	TBK1	0.50143484
78	OBSCN	0.48678784
79	CSNK1G1	0.48525942
80	ABL1	0.48258537
81	CHUK	0.47653598
82	TESK2	0.47202729
83	ZAP70	0.46121711
84	GRK5	0.45056446
85	CAMKK2	0.44230589
86	EIF2AK1	0.43587432
87	DYRK2	0.43420743
88	PLK3	0.43403437
89	BUB1	0.43020299
90	DAPK3	0.42054501
91	ILK	0.40977853
92	PASK	0.40514084
93	HCK	0.40234555
94	TNK2	0.33663101
95	PLK4	0.33525762
96	PRKCA	0.32949005
97	EGFR	0.31480141
98	ATR	0.29661639
99	MUSK	0.28984514
100	CSNK1A1	0.28582984

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.19463117
2	Allograft rejection_Homo sapiens_hsa05330	4.26945051
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	4.08053934
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.93249042
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.82089946
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.38878628
7	Proteasome_Homo sapiens_hsa03050	2.77580374
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.54010361
9	Antigen processing and presentation_Homo sapiens_hsa04612	2.40041006
10	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.38399160
11	Parkinsons disease_Homo sapiens_hsa05012	2.04357062
12	Rheumatoid arthritis_Homo sapiens_hsa05323	2.02983692
13	Ribosome_Homo sapiens_hsa03010	1.92104344
14	Primary immunodeficiency_Homo sapiens_hsa05340	1.90316353
15	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.86922944
16	Viral myocarditis_Homo sapiens_hsa05416	1.80250702
17	Caffeine metabolism_Homo sapiens_hsa00232	1.75350403
18	Protein export_Homo sapiens_hsa03060	1.75308033
19	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.53855348
20	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.52463585
21	Leishmaniasis_Homo sapiens_hsa05140	1.49992641
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.46571073
23	RNA polymerase_Homo sapiens_hsa03020	1.43109323
24	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33513027
25	Phototransduction_Homo sapiens_hsa04744	1.32344642
26	Alzheimers disease_Homo sapiens_hsa05010	1.29390156
27	Nitrogen metabolism_Homo sapiens_hsa00910	1.26002037
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.24284586
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.18441373
30	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14641289
31	One carbon pool by folate_Homo sapiens_hsa00670	1.14522772
32	RNA degradation_Homo sapiens_hsa03018	1.10840929
33	Cardiac muscle contraction_Homo sapiens_hsa04260	1.08885622
34	Huntingtons disease_Homo sapiens_hsa05016	1.08602776
35	Homologous recombination_Homo sapiens_hsa03440	1.08126702
36	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.98787204
37	Tryptophan metabolism_Homo sapiens_hsa00380	0.94449092
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.92660029
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.90796614
40	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.84128097
41	Ether lipid metabolism_Homo sapiens_hsa00565	0.78689391
42	Propanoate metabolism_Homo sapiens_hsa00640	0.76292291
43	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.76213213
44	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.74093631
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.73857597
46	Basal transcription factors_Homo sapiens_hsa03022	0.71094311
47	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.69818564
48	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.69477252
49	Olfactory transduction_Homo sapiens_hsa04740	0.66767040
50	Herpes simplex infection_Homo sapiens_hsa05168	0.64689397
51	Purine metabolism_Homo sapiens_hsa00230	0.61931301
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.61838671
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.61091441
54	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.60987794
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60959994
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.59038184
57	Toxoplasmosis_Homo sapiens_hsa05145	0.58994143
58	Peroxisome_Homo sapiens_hsa04146	0.58211658
59	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.56557953
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55735718
61	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.53770501
62	Nucleotide excision repair_Homo sapiens_hsa03420	0.52367125
63	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.52111108
64	Tuberculosis_Homo sapiens_hsa05152	0.52065961
65	Collecting duct acid secretion_Homo sapiens_hsa04966	0.47662704
66	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.45558628
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45069775
68	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.44915728
69	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44402372
70	Spliceosome_Homo sapiens_hsa03040	0.41572712
71	Retinol metabolism_Homo sapiens_hsa00830	0.40425360
72	Base excision repair_Homo sapiens_hsa03410	0.39899493
73	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.39442567
74	Salivary secretion_Homo sapiens_hsa04970	0.39020840
75	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.38414738
76	Regulation of autophagy_Homo sapiens_hsa04140	0.37831259
77	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.37254055
78	RNA transport_Homo sapiens_hsa03013	0.37196667
79	Butanoate metabolism_Homo sapiens_hsa00650	0.37173282
80	Taste transduction_Homo sapiens_hsa04742	0.34898577
81	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.34801053
82	Metabolic pathways_Homo sapiens_hsa01100	0.33648975
83	Fat digestion and absorption_Homo sapiens_hsa04975	0.33213063
84	Phagosome_Homo sapiens_hsa04145	0.31995151
85	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.31664435
86	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.31361010
87	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.30676509
88	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.30088654
89	Non-homologous end-joining_Homo sapiens_hsa03450	0.29912810
90	Influenza A_Homo sapiens_hsa05164	0.29888271
91	Sulfur metabolism_Homo sapiens_hsa00920	0.28674557
92	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.27676182
93	Mismatch repair_Homo sapiens_hsa03430	0.25689166
94	Morphine addiction_Homo sapiens_hsa05032	0.24439957
95	DNA replication_Homo sapiens_hsa03030	0.23254012
96	African trypanosomiasis_Homo sapiens_hsa05143	0.21582995
97	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.20345180
98	Selenocompound metabolism_Homo sapiens_hsa00450	0.19942203
99	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.19670223
100	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.16739496

RPL7P33

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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