RPL7P35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1coenzyme catabolic process (GO:0009109)9.12050775
2one-carbon compound transport (GO:0019755)6.50651594
3regulation of immunoglobulin secretion (GO:0051023)6.24220092
4regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)6.14597733
5positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.73588292
6cofactor catabolic process (GO:0051187)5.35289134
7regulation of isotype switching to IgG isotypes (GO:0048302)5.14602736
8protein-chromophore linkage (GO:0018298)5.08867100
9polyol transport (GO:0015791)4.74682383
10GTP biosynthetic process (GO:0006183)4.72069055
11positive regulation of interleukin-17 production (GO:0032740)4.49210972
12UTP biosynthetic process (GO:0006228)4.45411522
13UTP metabolic process (GO:0046051)4.30821937
14regulation of regulatory T cell differentiation (GO:0045589)4.16123832
15negative regulation of B cell apoptotic process (GO:0002903)4.08242138
16positive regulation of isotype switching (GO:0045830)4.02756384
17positive regulation of prostaglandin secretion (GO:0032308)3.93691668
18regulation of prostaglandin secretion (GO:0032306)3.90997006
19protein neddylation (GO:0045116)3.83524641
20epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.75055409
21regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)3.69970897
22DNA deamination (GO:0045006)3.68180721
23positive regulation of DNA recombination (GO:0045911)3.64974655
24purine nucleotide salvage (GO:0032261)3.62601513
25negative regulation of macrophage differentiation (GO:0045650)3.60869963
26negative regulation of telomere maintenance (GO:0032205)3.59170743
27response to pheromone (GO:0019236)3.57261886
28nephron tubule development (GO:0072080)3.56209229
29auditory receptor cell stereocilium organization (GO:0060088)3.55209166
30ribosomal small subunit assembly (GO:0000028)3.53090841
31pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.52020734
32negative regulation of T cell differentiation in thymus (GO:0033085)3.49157514
33phosphatidylinositol acyl-chain remodeling (GO:0036149)3.48748541
34regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.45729147
35platelet dense granule organization (GO:0060155)3.42827748
36multicellular organism reproduction (GO:0032504)3.41505538
37spermatid nucleus differentiation (GO:0007289)3.38957777
38transcription from mitochondrial promoter (GO:0006390)3.30838182
39renal tubule development (GO:0061326)3.22214718
40positive regulation of fatty acid transport (GO:2000193)3.19053928
41retinal rod cell development (GO:0046548)3.10150544
42ether lipid metabolic process (GO:0046485)3.08997153
43guanosine-containing compound biosynthetic process (GO:1901070)3.06948102
44pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.04847703
45nucleoside diphosphate phosphorylation (GO:0006165)3.01855963
46oxidative phosphorylation (GO:0006119)2.99134043
47phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.97836997
48forebrain morphogenesis (GO:0048853)2.95886166
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94322368
50deoxyribonucleotide catabolic process (GO:0009264)2.93319850
51positive regulation of lamellipodium assembly (GO:0010592)2.92715893
52pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.91136408
53positive regulation of icosanoid secretion (GO:0032305)2.87578423
54behavioral response to nicotine (GO:0035095)2.87472028
55pyrimidine ribonucleotide biosynthetic process (GO:0009220)2.87144610
56negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.85381480
57CTP metabolic process (GO:0046036)2.82365106
58CTP biosynthetic process (GO:0006241)2.82365106
59purine-containing compound salvage (GO:0043101)2.81471321
60G-protein coupled receptor internalization (GO:0002031)2.81115419
61tryptophan metabolic process (GO:0006568)2.79918804
62purine deoxyribonucleotide catabolic process (GO:0009155)2.79510943
63positive regulation of growth hormone secretion (GO:0060124)2.79419509
64gene silencing by RNA (GO:0031047)2.78333272
65photoreceptor cell maintenance (GO:0045494)2.78195475
66pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77037517
67pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.75160790
68pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.73651551
69proteasome assembly (GO:0043248)2.73164315
70pyrimidine nucleotide catabolic process (GO:0006244)2.72560314
71viral transcription (GO:0019083)2.72217474
72pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.71941329
73quinone metabolic process (GO:1901661)2.71054608
74indolalkylamine metabolic process (GO:0006586)2.69686309
75regulation of B cell apoptotic process (GO:0002902)2.69298640
76nephron epithelium development (GO:0072009)2.68371801
77pyrimidine nucleotide biosynthetic process (GO:0006221)2.65402178
78DNA double-strand break processing (GO:0000729)2.64611657
79adenosine metabolic process (GO:0046085)2.64013764
80rhodopsin mediated signaling pathway (GO:0016056)2.63427064
81pyrimidine ribonucleoside metabolic process (GO:0046131)2.63197286
82pyrimidine ribonucleotide metabolic process (GO:0009218)2.62278363
83phosphatidylserine acyl-chain remodeling (GO:0036150)2.61827507
84rRNA modification (GO:0000154)2.61649878
85left/right axis specification (GO:0070986)2.61565942
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.61082057
87pyrimidine nucleoside biosynthetic process (GO:0046134)2.60302487
88mannosylation (GO:0097502)2.59560982
89negative regulation of T cell receptor signaling pathway (GO:0050860)2.58609811
90translational elongation (GO:0006414)2.57889794
91phosphorylated carbohydrate dephosphorylation (GO:0046838)2.57084542
92inositol phosphate dephosphorylation (GO:0046855)2.57084542
93pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.57066487
94positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.56472364
95mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.56472364
96regulation of icosanoid secretion (GO:0032303)2.54983238
97pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.54891993
98somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.54766062
99isotype switching (GO:0045190)2.54766062
100somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.54766062

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ELF1_17652178_ChIP-ChIP_JURKAT_Human3.28567924
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.07203479
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81570364
4IRF8_22096565_ChIP-ChIP_GC-B_Human2.68510472
5MYC_18940864_ChIP-ChIP_HL60_Human2.59998694
6ZNF274_21170338_ChIP-Seq_K562_Hela2.58572908
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58000796
8TAF15_26573619_Chip-Seq_HEK293_Human2.47511002
9IGF1R_20145208_ChIP-Seq_DFB_Human2.43647460
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.34253327
11IRF1_19129219_ChIP-ChIP_H3396_Human2.33610709
12EWS_26573619_Chip-Seq_HEK293_Human2.26356579
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.19681180
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.18503639
15FLI1_27457419_Chip-Seq_LIVER_Mouse2.08658663
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03801432
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02671250
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95574318
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95569090
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.95102207
21P300_19829295_ChIP-Seq_ESCs_Human1.91342881
22CBP_20019798_ChIP-Seq_JUKART_Human1.90838013
23IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.90838013
24E2F7_22180533_ChIP-Seq_HELA_Human1.82758412
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77477899
26VDR_23849224_ChIP-Seq_CD4+_Human1.77473377
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.77272700
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.75725250
29ER_23166858_ChIP-Seq_MCF-7_Human1.73722351
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.71459828
31TP63_19390658_ChIP-ChIP_HaCaT_Human1.67994979
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.66554738
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.63990227
34EZH2_22144423_ChIP-Seq_EOC_Human1.63904649
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62006114
36GBX2_23144817_ChIP-Seq_PC3_Human1.59689769
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.59438384
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.59438384
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56452502
40SOX2_19829295_ChIP-Seq_ESCs_Human1.56246728
41NANOG_19829295_ChIP-Seq_ESCs_Human1.56246728
42NCOR_22424771_ChIP-Seq_293T_Human1.48456711
43EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.46918140
44PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46471384
45AUTS2_25519132_ChIP-Seq_293T-REX_Human1.46349921
46ELK1_19687146_ChIP-ChIP_HELA_Human1.43906782
47VDR_22108803_ChIP-Seq_LS180_Human1.43669255
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40644757
49AR_20517297_ChIP-Seq_VCAP_Human1.36678590
50MYC_19829295_ChIP-Seq_ESCs_Human1.35257181
51FUS_26573619_Chip-Seq_HEK293_Human1.34598057
52ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34011047
53TP53_22573176_ChIP-Seq_HFKS_Human1.30598463
54CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28400864
55BCAT_22108803_ChIP-Seq_LS180_Human1.28396109
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.26867762
57RNF2_27304074_Chip-Seq_NSC_Mouse1.24610232
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24086875
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21260279
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.20523678
61SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20247441
62GATA3_21878914_ChIP-Seq_MCF-7_Human1.19631407
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19055010
64FOXP3_21729870_ChIP-Seq_TREG_Human1.16483182
65TCF4_22108803_ChIP-Seq_LS180_Human1.16339364
66RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16108137
67EGR1_19032775_ChIP-ChIP_M12_Human1.15974223
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15379192
69FOXA1_21572438_ChIP-Seq_LNCaP_Human1.14555904
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.13515709
71MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13466714
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13035838
73ESET_19884257_ChIP-Seq_ESCs_Mouse1.12234705
74CDX2_22108803_ChIP-Seq_LS180_Human1.09027238
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08878589
76CBX2_27304074_Chip-Seq_ESCs_Mouse1.08866588
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08594048
78TAL1_26923725_Chip-Seq_HPCs_Mouse1.07790638
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.07770583
80STAT1_17558387_ChIP-Seq_HELA_Human1.07594586
81TAF2_19829295_ChIP-Seq_ESCs_Human1.06832086
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05016667
83NANOG_20526341_ChIP-Seq_ESCs_Human1.04961575
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.04722208
85P300_18555785_Chip-Seq_ESCs_Mouse1.04573470
86PHF8_20622853_ChIP-Seq_HELA_Human1.01986985
87LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01852033
88NOTCH1_21737748_ChIP-Seq_TLL_Human1.00207835
89OCT4_18555785_Chip-Seq_ESCs_Mouse0.99168951
90CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98434429
91TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97332994
92P53_22387025_ChIP-Seq_ESCs_Mouse0.96936603
93EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.95852666
94RUNX2_22187159_ChIP-Seq_PCA_Human0.95293234
95PRDM14_20953172_ChIP-Seq_ESCs_Human0.94798863
96JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.94409132
97NANOG_18555785_Chip-Seq_ESCs_Mouse0.93781815
98KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92583003
99GATA3_27048872_Chip-Seq_THYMUS_Human0.92259768
100TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.91441781

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002638_abnormal_pupillary_reflex4.88361292
2MP0000566_synostosis3.47076193
3MP0003011_delayed_dark_adaptation3.33889514
4MP0005084_abnormal_gallbladder_morpholo3.32785954
5MP0005083_abnormal_biliary_tract3.23942295
6MP0006292_abnormal_olfactory_placode3.06965039
7MP0002102_abnormal_ear_morphology2.86200866
8MP0001835_abnormal_antigen_presentation2.69777652
9MP0005253_abnormal_eye_physiology2.32022393
10MP0005671_abnormal_response_to2.31751345
11MP0005085_abnormal_gallbladder_physiolo2.27774130
12MP0002909_abnormal_adrenal_gland2.21650803
13MP0005410_abnormal_fertilization2.17935630
14MP0001764_abnormal_homeostasis2.12952484
15MP0004147_increased_porphyrin_level2.07975932
16MP0000604_amyloidosis2.04628434
17MP0002138_abnormal_hepatobiliary_system1.98470761
18MP0002928_abnormal_bile_duct1.79166218
19MP0001188_hyperpigmentation1.77843339
20MP0005551_abnormal_eye_electrophysiolog1.75111861
21MP0002234_abnormal_pharynx_morphology1.72832065
22MP0001502_abnormal_circadian_rhythm1.70259972
23MP0005365_abnormal_bile_salt1.68789211
24MP0000049_abnormal_middle_ear1.64350046
25MP0001664_abnormal_digestion1.58829294
26MP0002006_tumorigenesis1.55836126
27MP0000372_irregular_coat_pigmentation1.55645486
28MP0003300_gastrointestinal_ulcer1.54540708
29MP0008877_abnormal_DNA_methylation1.54532422
30MP0009697_abnormal_copulation1.54115437
31MP0002166_altered_tumor_susceptibility1.49644147
32MP0006072_abnormal_retinal_apoptosis1.49562923
33MP0001905_abnormal_dopamine_level1.48854416
34MP0002653_abnormal_ependyma_morphology1.43636658
35MP0000465_gastrointestinal_hemorrhage1.41232140
36MP0004043_abnormal_pH_regulation1.34774968
37MP0002160_abnormal_reproductive_system1.30923737
38MP0001501_abnormal_sleep_pattern1.29874864
39MP0002009_preneoplasia1.24526449
40MP0006082_CNS_inflammation1.21761638
41MP0004134_abnormal_chest_morphology1.20858260
42MP0006276_abnormal_autonomic_nervous1.15346336
43MP0008875_abnormal_xenobiotic_pharmacok1.15082042
44MP0010386_abnormal_urinary_bladder1.14551742
45MP0008872_abnormal_physiological_respon1.13403426
46MP0004885_abnormal_endolymph1.11245773
47MP0002938_white_spotting1.09389273
48MP0008058_abnormal_DNA_repair1.08011762
49MP0000383_abnormal_hair_follicle1.02499406
50MP0001529_abnormal_vocalization1.02007299
51MP0000631_abnormal_neuroendocrine_gland0.99653417
52MP0005389_reproductive_system_phenotype0.97974024
53MP0004742_abnormal_vestibular_system0.97019620
54MP0003329_amyloid_beta_deposits0.95373813
55MP0003763_abnormal_thymus_physiology0.95137199
56MP0001853_heart_inflammation0.94964962
57MP0003195_calcinosis0.94237054
58MP0003122_maternal_imprinting0.93664728
59MP0008789_abnormal_olfactory_epithelium0.93650242
60MP0009379_abnormal_foot_pigmentation0.88163606
61MP0005379_endocrine/exocrine_gland_phen0.88152019
62MP0002148_abnormal_hypersensitivity_rea0.87148129
63MP0003943_abnormal_hepatobiliary_system0.86711564
64MP0003937_abnormal_limbs/digits/tail_de0.85571289
65MP0003880_abnormal_central_pattern0.85486965
66MP0000538_abnormal_urinary_bladder0.84136591
67MP0001270_distended_abdomen0.83260319
68MP0009333_abnormal_splenocyte_physiolog0.83189130
69MP0002933_joint_inflammation0.82890335
70MP0004808_abnormal_hematopoietic_stem0.81851980
71MP0004782_abnormal_surfactant_physiolog0.80500539
72MP0009785_altered_susceptibility_to0.79949957
73MP0009840_abnormal_foam_cell0.79624412
74MP0010678_abnormal_skin_adnexa0.78912940
75MP0001800_abnormal_humoral_immune0.78479704
76MP0005646_abnormal_pituitary_gland0.78380923
77MP0000026_abnormal_inner_ear0.78351015
78MP0000685_abnormal_immune_system0.76976194
79MP0000427_abnormal_hair_cycle0.76452506
80MP0000470_abnormal_stomach_morphology0.76042559
81MP0004272_abnormal_basement_membrane0.74501756
82MP0005220_abnormal_exocrine_pancreas0.74500422
83MP0001968_abnormal_touch/_nociception0.74182075
84MP0009745_abnormal_behavioral_response0.73612356
85MP0002723_abnormal_immune_serum0.72229342
86MP0008961_abnormal_basal_metabolism0.72172578
87MP0004133_heterotaxia0.71999876
88MP0002452_abnormal_antigen_presenting0.71855150
89MP0003252_abnormal_bile_duct0.70412446
90MP0001963_abnormal_hearing_physiology0.69963016
91MP0002693_abnormal_pancreas_physiology0.69602466
92MP0009278_abnormal_bone_marrow0.69262120
93MP0000230_abnormal_systemic_arterial0.68846581
94MP0003567_abnormal_fetal_cardiomyocyte0.67492726
95MP0005387_immune_system_phenotype0.66896107
96MP0001790_abnormal_immune_system0.66896107
97MP0003137_abnormal_impulse_conducting0.66052563
98MP0005167_abnormal_blood-brain_barrier0.65198808
99MP0002752_abnormal_somatic_nervous0.63991160
100MP0005397_hematopoietic_system_phenotyp0.63972796

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)7.11907179
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.04794074
3Absent/shortened dynein arms (HP:0200106)6.04794074
4Type II lissencephaly (HP:0007260)5.37349111
5Stomatitis (HP:0010280)4.96370979
6Increased IgM level (HP:0003496)4.87447186
7Abnormal rod and cone electroretinograms (HP:0008323)4.86485188
8Abnormal ciliary motility (HP:0012262)4.42240236
9Abnormal respiratory motile cilium physiology (HP:0012261)4.12862610
10Abnormal respiratory motile cilium morphology (HP:0005938)3.98433853
11Abnormal respiratory epithelium morphology (HP:0012253)3.98433853
12Abolished electroretinogram (ERG) (HP:0000550)3.61734837
13IgG deficiency (HP:0004315)3.56603397
14Bile duct proliferation (HP:0001408)3.49894460
15Abnormal biliary tract physiology (HP:0012439)3.49894460
16Attenuation of retinal blood vessels (HP:0007843)3.35781714
17Decreased central vision (HP:0007663)3.34064984
18True hermaphroditism (HP:0010459)3.32387093
193-Methylglutaconic aciduria (HP:0003535)3.31449223
20Retinal dysplasia (HP:0007973)3.31403071
21Hyperglycinuria (HP:0003108)3.28582578
22Calf muscle hypertrophy (HP:0008981)3.27769074
23Thyroiditis (HP:0100646)3.14310260
24Abnormality of glycine metabolism (HP:0010895)3.05650477
25Abnormality of serine family amino acid metabolism (HP:0010894)3.05650477
26Chorioretinal atrophy (HP:0000533)3.00065485
27Pancreatic cysts (HP:0001737)2.98911179
28Multiple enchondromatosis (HP:0005701)2.96503938
29Muscle hypertrophy of the lower extremities (HP:0008968)2.88539276
30Sensory axonal neuropathy (HP:0003390)2.87937124
31Pancreatic fibrosis (HP:0100732)2.85682970
32Mesangial abnormality (HP:0001966)2.80596112
33Hyperglycinemia (HP:0002154)2.79594269
34Decreased electroretinogram (ERG) amplitude (HP:0000654)2.78966410
35Sensorimotor neuropathy (HP:0007141)2.78236094
36Severe combined immunodeficiency (HP:0004430)2.74362155
37Congenital stationary night blindness (HP:0007642)2.69663453
38Nephronophthisis (HP:0000090)2.69120084
39Colon cancer (HP:0003003)2.57145874
40Abnormality of the renal cortex (HP:0011035)2.52908907
41Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.51832939
42Renal cortical cysts (HP:0000803)2.48993137
43Dicarboxylic aciduria (HP:0003215)2.47945590
44Abnormality of dicarboxylic acid metabolism (HP:0010995)2.47945590
45Absent thumb (HP:0009777)2.47539624
46Molar tooth sign on MRI (HP:0002419)2.44783543
47Abnormality of midbrain morphology (HP:0002418)2.44783543
48Elevated erythrocyte sedimentation rate (HP:0003565)2.41347040
49Bony spicule pigmentary retinopathy (HP:0007737)2.36902613
50Polydipsia (HP:0001959)2.32786472
51Abnormal drinking behavior (HP:0030082)2.32786472
52Supernumerary spleens (HP:0009799)2.26444490
53Autoimmune thrombocytopenia (HP:0001973)2.16906161
54Cystic liver disease (HP:0006706)2.15982478
55Recurrent sinusitis (HP:0011108)2.13918634
56Gastrointestinal stroma tumor (HP:0100723)2.13672270
57Constricted visual fields (HP:0001133)2.11323741
58Abnormality of the renal medulla (HP:0100957)2.10023520
59B lymphocytopenia (HP:0010976)2.06152859
60Abnormality of B cell number (HP:0010975)2.04548574
61Hypergammaglobulinemia (HP:0010702)2.04383575
62Severe muscular hypotonia (HP:0006829)1.98335662
63Tubular atrophy (HP:0000092)1.93997226
64Lissencephaly (HP:0001339)1.92781212
65Abnormality of eosinophils (HP:0001879)1.92519344
66Palpebral edema (HP:0100540)1.92199242
67Esophageal neoplasm (HP:0100751)1.91951089
68Neoplasm of head and neck (HP:0012288)1.91951089
69Combined immunodeficiency (HP:0005387)1.91110866
70Poor speech (HP:0002465)1.87940622
71Pendular nystagmus (HP:0012043)1.87723334
72Cerebellar dysplasia (HP:0007033)1.87292941
73Abnormality of T cell physiology (HP:0011840)1.79871716
74Keratoconus (HP:0000563)1.78714981
75Increased corneal curvature (HP:0100692)1.78714981
76Gonadal dysgenesis (HP:0000133)1.78623446
77Ketosis (HP:0001946)1.78332052
78Meningocele (HP:0002435)1.75306069
79Aplasia/Hypoplasia of the tongue (HP:0010295)1.74455042
80Encephalitis (HP:0002383)1.74421463
81Chronic bronchitis (HP:0004469)1.74353684
82Abnormality of T cells (HP:0002843)1.72314788
83Concave nail (HP:0001598)1.70211956
84Abnormality of macular pigmentation (HP:0008002)1.70091360
85Respiratory difficulties (HP:0002880)1.69709922
86Cerebral palsy (HP:0100021)1.69426630
87Abnormality of T cell number (HP:0011839)1.69286964
88Anomalous pulmonary venous return (HP:0010772)1.68453593
89Cerebral edema (HP:0002181)1.65889334
90Abnormal hair whorl (HP:0010721)1.65638596
91Hypoplasia of the pons (HP:0012110)1.65086560
92Renal Fanconi syndrome (HP:0001994)1.64876560
93Abnormality of dentin (HP:0010299)1.64572086
94Pancytopenia (HP:0001876)1.64408664
95Thyroid-stimulating hormone excess (HP:0002925)1.64040722
96Spontaneous hematomas (HP:0007420)1.63880842
97Rhinitis (HP:0012384)1.63220700
98Abnormal cartilage morphology (HP:0002763)1.61584120
99T lymphocytopenia (HP:0005403)1.59902221
100Sclerocornea (HP:0000647)1.58493151

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK198.05329162
2FRK4.55313475
3NME13.10694568
4SIK32.37233136
5KIT2.32949632
6NUAK12.03170187
7TAOK31.88668484
8TXK1.81891457
9BCR1.71952862
10TESK21.71918254
11ADRBK21.71139603
12ERBB31.70340754
13MAP3K41.60486638
14TEC1.57788261
15WNK31.55364875
16BCKDK1.54334570
17VRK11.54127521
18OXSR11.43921290
19KDR1.41512539
20TESK11.41428138
21DAPK11.39621749
22MAP4K21.39513090
23SIK11.39274892
24ZAK1.31054651
25SIK21.30742956
26MST41.30453656
27PRKG21.27911057
28MATK1.27259988
29PAK61.26656956
30JAK31.25565899
31BMPR1B1.25180368
32NEK21.24530968
33DAPK21.21474485
34GRK11.20855545
35VRK21.19568858
36ITK1.18989132
37CSNK1G31.14762621
38PRKCQ1.13087375
39IKBKE1.07931966
40FLT31.01951607
41CSNK1A1L0.99131437
42MARK30.92395133
43TIE10.86493517
44MAPK130.83730263
45TRPM70.82189215
46STK390.80669850
47BTK0.79127210
48EIF2AK30.78762827
49CSNK1G10.78491118
50RPS6KA50.76425768
51DYRK20.76049723
52FGFR20.75428981
53NEK10.75007962
54MAP2K70.72649387
55TRIM280.72027881
56CSNK1G20.72019100
57RPS6KA60.68646942
58RPS6KA40.66308033
59MAPKAPK50.63408922
60INSRR0.61641809
61KSR10.61343421
62PINK10.61295942
63MAP3K60.60763651
64MUSK0.57207862
65PRKD30.56703630
66CAMK10.56632614
67STK110.56577478
68IRAK40.56287021
69RPS6KB10.55700260
70CHEK20.55682041
71EPHA30.54875312
72PAK30.53902410
73EIF2AK20.53781186
74OBSCN0.53470266
75TLK10.52328979
76PLK30.51910492
77CAMK40.51466350
78SYK0.51349232
79WNK40.51222367
80LCK0.49505987
81TAF10.48572999
82PRKCZ0.48361479
83RPS6KL10.46306709
84RPS6KC10.46306709
85IKBKB0.45462188
86PASK0.44804743
87ATR0.43826429
88PRKAA20.41725420
89RAF10.41243716
90PRKACA0.41213983
91DAPK30.40199982
92LYN0.39768249
93LIMK10.38484100
94PRKAA10.36169737
95NTRK20.36015054
96PRKCB0.34982769
97ADRBK10.34603072
98RPS6KB20.33087037
99PIM20.31335829
100PRKCA0.31069803

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.60568390
2Ribosome_Homo sapiens_hsa030103.07619104
3Asthma_Homo sapiens_hsa053103.05631485
4Allograft rejection_Homo sapiens_hsa053302.95560856
5Linoleic acid metabolism_Homo sapiens_hsa005912.81080043
6Autoimmune thyroid disease_Homo sapiens_hsa053202.79772128
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.63173694
8Proteasome_Homo sapiens_hsa030502.48897134
9Propanoate metabolism_Homo sapiens_hsa006402.41985365
10Arachidonic acid metabolism_Homo sapiens_hsa005902.40796512
11Basal transcription factors_Homo sapiens_hsa030222.35876595
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.32573030
13Oxidative phosphorylation_Homo sapiens_hsa001902.05700172
14Graft-versus-host disease_Homo sapiens_hsa053321.94242675
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87909963
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77309745
17Olfactory transduction_Homo sapiens_hsa047401.76690470
18Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.76280895
19Type I diabetes mellitus_Homo sapiens_hsa049401.71352473
20Hematopoietic cell lineage_Homo sapiens_hsa046401.64304786
21Caffeine metabolism_Homo sapiens_hsa002321.63714818
22Parkinsons disease_Homo sapiens_hsa050121.56533717
23Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53761567
24Peroxisome_Homo sapiens_hsa041461.42587252
25RNA polymerase_Homo sapiens_hsa030201.39465901
26Phototransduction_Homo sapiens_hsa047441.38075240
27Tryptophan metabolism_Homo sapiens_hsa003801.36601981
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.35579086
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.35233124
30Retinol metabolism_Homo sapiens_hsa008301.34554261
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33485412
32Fatty acid metabolism_Homo sapiens_hsa012121.32911229
33Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23656665
34Ether lipid metabolism_Homo sapiens_hsa005651.22547019
35RNA degradation_Homo sapiens_hsa030181.19587077
36Fat digestion and absorption_Homo sapiens_hsa049751.17619720
37Chemical carcinogenesis_Homo sapiens_hsa052041.12216686
38Protein export_Homo sapiens_hsa030601.11482689
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10682526
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10195640
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.09966976
42Rheumatoid arthritis_Homo sapiens_hsa053231.06704346
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.03932966
44Fatty acid degradation_Homo sapiens_hsa000711.02072096
45Huntingtons disease_Homo sapiens_hsa050161.01530855
46Cardiac muscle contraction_Homo sapiens_hsa042600.93675051
47Fanconi anemia pathway_Homo sapiens_hsa034600.92285001
48Base excision repair_Homo sapiens_hsa034100.91922574
49Pyrimidine metabolism_Homo sapiens_hsa002400.91647276
50Taste transduction_Homo sapiens_hsa047420.90122728
51Non-homologous end-joining_Homo sapiens_hsa034500.87439220
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.84589354
53T cell receptor signaling pathway_Homo sapiens_hsa046600.81951482
54Butanoate metabolism_Homo sapiens_hsa006500.81810232
55Antigen processing and presentation_Homo sapiens_hsa046120.80510580
56RNA transport_Homo sapiens_hsa030130.79450994
57Glutathione metabolism_Homo sapiens_hsa004800.79339222
58Alzheimers disease_Homo sapiens_hsa050100.78440489
59beta-Alanine metabolism_Homo sapiens_hsa004100.77012822
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75934363
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.75064584
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.73751863
63Malaria_Homo sapiens_hsa051440.71438133
64Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71119926
65Nucleotide excision repair_Homo sapiens_hsa034200.69490330
66One carbon pool by folate_Homo sapiens_hsa006700.68394482
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62908249
68Renin secretion_Homo sapiens_hsa049240.62051204
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61786119
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.61636155
71Systemic lupus erythematosus_Homo sapiens_hsa053220.60751712
72Nitrogen metabolism_Homo sapiens_hsa009100.59773862
73p53 signaling pathway_Homo sapiens_hsa041150.59675030
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.59531511
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59512357
76Salivary secretion_Homo sapiens_hsa049700.57077994
77Circadian entrainment_Homo sapiens_hsa047130.56842695
78Selenocompound metabolism_Homo sapiens_hsa004500.54790655
79Vitamin B6 metabolism_Homo sapiens_hsa007500.53571050
80Morphine addiction_Homo sapiens_hsa050320.52940119
81Metabolic pathways_Homo sapiens_hsa011000.50401976
82Purine metabolism_Homo sapiens_hsa002300.49653317
83Measles_Homo sapiens_hsa051620.48592062
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48512621
85Regulation of autophagy_Homo sapiens_hsa041400.46881452
86Steroid biosynthesis_Homo sapiens_hsa001000.44453824
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42934965
88Serotonergic synapse_Homo sapiens_hsa047260.40043445
89ABC transporters_Homo sapiens_hsa020100.36712333
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36025546
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.35997422
92Pentose phosphate pathway_Homo sapiens_hsa000300.34868244
93GABAergic synapse_Homo sapiens_hsa047270.33976005
94Nicotine addiction_Homo sapiens_hsa050330.29972291
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.28296093
96Carbon metabolism_Homo sapiens_hsa012000.28120574
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.27441358
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.26609074
99PPAR signaling pathway_Homo sapiens_hsa033200.26372749
100Sulfur metabolism_Homo sapiens_hsa009200.25458750

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