RPL7P36

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)4.72629342
2tryptophan catabolic process (GO:0006569)4.03905613
3indole-containing compound catabolic process (GO:0042436)4.03905613
4indolalkylamine catabolic process (GO:0046218)4.03905613
5tryptophan metabolic process (GO:0006568)3.98134905
6energy coupled proton transport, down electrochemical gradient (GO:0015985)3.96348334
7ATP synthesis coupled proton transport (GO:0015986)3.96348334
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.86792679
9kynurenine metabolic process (GO:0070189)3.82710303
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.76331966
11regulation of isotype switching to IgG isotypes (GO:0048302)3.71251636
12regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.69413853
13protein neddylation (GO:0045116)3.61813228
14positive regulation of prostaglandin secretion (GO:0032308)3.54858224
15RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.54092660
16proteasome assembly (GO:0043248)3.42426455
17negative regulation of T cell differentiation in thymus (GO:0033085)3.33441576
18regulation of memory T cell differentiation (GO:0043380)3.31149695
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.26731925
20nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.25363807
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.22208044
22respiratory chain complex IV assembly (GO:0008535)3.22120307
23maturation of 5.8S rRNA (GO:0000460)3.19758373
24protein deneddylation (GO:0000338)3.17351670
25immunoglobulin mediated immune response (GO:0016064)3.17204467
26indolalkylamine metabolic process (GO:0006586)3.16764678
27exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.16576462
28cullin deneddylation (GO:0010388)3.13855976
29positive regulation of DNA recombination (GO:0045911)3.13014175
30positive regulation of activated T cell proliferation (GO:0042104)3.11053107
31positive regulation of isotype switching (GO:0045830)3.08910318
32ribosomal large subunit biogenesis (GO:0042273)3.04876228
33regulation of immunoglobulin secretion (GO:0051023)3.04620013
34L-fucose catabolic process (GO:0042355)3.04468755
35fucose catabolic process (GO:0019317)3.04468755
36L-fucose metabolic process (GO:0042354)3.04468755
37phosphatidylinositol acyl-chain remodeling (GO:0036149)3.04464936
38adenosine metabolic process (GO:0046085)3.03446284
39positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.99780181
40regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.93359584
41regulation of prostaglandin secretion (GO:0032306)2.91090817
42B cell mediated immunity (GO:0019724)2.88134048
43regulation of regulatory T cell differentiation (GO:0045589)2.86570748
44cytochrome complex assembly (GO:0017004)2.86160243
45rRNA catabolic process (GO:0016075)2.85386059
46electron transport chain (GO:0022900)2.84973594
47piRNA metabolic process (GO:0034587)2.82767343
48respiratory electron transport chain (GO:0022904)2.82682369
49positive regulation of T cell differentiation in thymus (GO:0033089)2.82644691
50rRNA modification (GO:0000154)2.81185594
51negative regulation of thymocyte apoptotic process (GO:0070244)2.77865943
52protein complex biogenesis (GO:0070271)2.77804747
53negative regulation of mast cell activation (GO:0033004)2.77454609
54positive regulation of defense response to virus by host (GO:0002230)2.76713926
55behavioral response to nicotine (GO:0035095)2.76586423
56tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.76264263
57RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.76264263
58mitochondrial respiratory chain complex assembly (GO:0033108)2.75685143
59DNA double-strand break processing (GO:0000729)2.73621858
60ribosomal small subunit assembly (GO:0000028)2.71203958
61positive regulation of B cell mediated immunity (GO:0002714)2.71040235
62positive regulation of immunoglobulin mediated immune response (GO:0002891)2.71040235
63water-soluble vitamin biosynthetic process (GO:0042364)2.70742590
64DNA catabolic process, exonucleolytic (GO:0000738)2.69538624
65epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69534153
66positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.67369017
67oxidative phosphorylation (GO:0006119)2.66071222
68regulation of chronic inflammatory response (GO:0002676)2.63899097
69mitochondrial respiratory chain complex I assembly (GO:0032981)2.62872302
70NADH dehydrogenase complex assembly (GO:0010257)2.62872302
71mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.62872302
72regulation of thymocyte apoptotic process (GO:0070243)2.61241092
73positive regulation of T cell mediated cytotoxicity (GO:0001916)2.60913664
74response to interferon-beta (GO:0035456)2.60577965
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.60025858
76regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.59794822
77mast cell activation (GO:0045576)2.59793438
78positive regulation of fatty acid transport (GO:2000193)2.58270731
79S-adenosylmethionine metabolic process (GO:0046500)2.56497862
80regulation of germinal center formation (GO:0002634)2.55905603
81positive regulation of T-helper 1 type immune response (GO:0002827)2.54306082
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.50448315
83negative regulation of B cell apoptotic process (GO:0002903)2.50271622
84regulation of cellular amino acid metabolic process (GO:0006521)2.49992315
85spliceosomal complex assembly (GO:0000245)2.48026095
86negative regulation of DNA-dependent DNA replication (GO:2000104)2.47990997
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.47736533
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.47736533
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.47736533
90regulation of B cell apoptotic process (GO:0002902)2.45721129
91positive regulation of alpha-beta T cell proliferation (GO:0046641)2.45254609
92GTP biosynthetic process (GO:0006183)2.44691883
93phosphatidylserine acyl-chain remodeling (GO:0036150)2.44068940
94one-carbon compound transport (GO:0019755)2.42645517
95purine nucleotide salvage (GO:0032261)2.42123062
96purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.42024368
97positive regulation of interleukin-17 production (GO:0032740)2.41448382
98cellular biogenic amine catabolic process (GO:0042402)2.41014842
99amine catabolic process (GO:0009310)2.41014842
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.40914753

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.76238682
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.75697917
3ZNF274_21170338_ChIP-Seq_K562_Hela3.51672375
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.45230691
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26723553
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.14236340
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.11338127
8ELF1_17652178_ChIP-ChIP_JURKAT_Human2.92969451
9VDR_22108803_ChIP-Seq_LS180_Human2.82688504
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71806649
11VDR_23849224_ChIP-Seq_CD4+_Human2.71150391
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62951987
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.58516027
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.33128563
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.30646033
16ELK1_19687146_ChIP-ChIP_HELA_Human2.21526376
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.19233347
18IGF1R_20145208_ChIP-Seq_DFB_Human2.17855415
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.07458012
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.00643944
21FOXP3_21729870_ChIP-Seq_TREG_Human2.00170628
22PCGF2_27294783_Chip-Seq_ESCs_Mouse1.99158232
23MYC_18940864_ChIP-ChIP_HL60_Human1.90264510
24FUS_26573619_Chip-Seq_HEK293_Human1.83433230
25SRF_21415370_ChIP-Seq_HL-1_Mouse1.83280768
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.81362055
27PCGF2_27294783_Chip-Seq_NPCs_Mouse1.75851496
28EWS_26573619_Chip-Seq_HEK293_Human1.75626411
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.70543068
30GATA3_26560356_Chip-Seq_TH2_Human1.67579260
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57612280
32TP53_22573176_ChIP-Seq_HFKS_Human1.56153762
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.50692772
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.44935273
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.44013679
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.43663127
37AR_20517297_ChIP-Seq_VCAP_Human1.41782239
38IRF1_19129219_ChIP-ChIP_H3396_Human1.41530810
39FOXA1_27270436_Chip-Seq_PROSTATE_Human1.41229382
40FOXA1_25329375_ChIP-Seq_VCAP_Human1.41229382
41HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39170414
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.39127426
43POU3F2_20337985_ChIP-ChIP_501MEL_Human1.39097843
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.37542907
45MYB_26560356_Chip-Seq_TH2_Human1.36577363
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.36372704
47ER_23166858_ChIP-Seq_MCF-7_Human1.32766052
48FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32323629
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31000785
50CBP_20019798_ChIP-Seq_JUKART_Human1.31000785
51SOX2_19829295_ChIP-Seq_ESCs_Human1.29906455
52NANOG_19829295_ChIP-Seq_ESCs_Human1.29906455
53NOTCH1_21737748_ChIP-Seq_TLL_Human1.27816380
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27096039
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.25486159
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.24267637
57CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24152532
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22326629
59LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.22031080
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.21247767
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20629161
62TAF15_26573619_Chip-Seq_HEK293_Human1.20495561
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20080478
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.19923812
65AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17185593
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.16678088
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15369250
68P300_19829295_ChIP-Seq_ESCs_Human1.14773981
69NCOR_22424771_ChIP-Seq_293T_Human1.14661050
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14104237
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12778890
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.11310736
73NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10967867
74TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.10768924
75MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10149950
76PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08676949
77GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.08440309
78FOXH1_21741376_ChIP-Seq_EPCs_Human1.07846174
79E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06776999
80ERG_20517297_ChIP-Seq_VCAP_Human1.06009026
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.05414012
82HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05084549
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02465029
84HOXB7_26014856_ChIP-Seq_BT474_Human1.01988348
85FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00728617
86GATA3_27048872_Chip-Seq_THYMUS_Human1.00461000
87GATA3_26560356_Chip-Seq_TH1_Human1.00161864
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99923856
89MYC_19829295_ChIP-Seq_ESCs_Human0.98008080
90SPI1_23547873_ChIP-Seq_NB4_Human0.97006127
91TAF2_19829295_ChIP-Seq_ESCs_Human0.95503369
92NANOG_20526341_ChIP-Seq_ESCs_Human0.94705441
93CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94161004
94EZH2_27294783_Chip-Seq_NPCs_Mouse0.93174644
95KLF5_20875108_ChIP-Seq_MESCs_Mouse0.92524476
96ELK1_22589737_ChIP-Seq_MCF10A_Human0.91986223
97EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91817881
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.91546712
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90682149
100CIITA_25753668_ChIP-Seq_RAJI_Human0.89919598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.38950322
2MP0002138_abnormal_hepatobiliary_system3.93979947
3MP0005671_abnormal_response_to3.22110386
4MP0003806_abnormal_nucleotide_metabolis2.76855846
5MP0008875_abnormal_xenobiotic_pharmacok2.66506880
6MP0002148_abnormal_hypersensitivity_rea2.48147630
7MP0006072_abnormal_retinal_apoptosis2.28840871
8MP0002166_altered_tumor_susceptibility2.22241336
9MP0001873_stomach_inflammation2.13280010
10MP0005646_abnormal_pituitary_gland2.10238433
11MP0008872_abnormal_physiological_respon2.09442455
12MP0003011_delayed_dark_adaptation2.02623755
13MP0001800_abnormal_humoral_immune1.98552944
14MP0009785_altered_susceptibility_to1.91772384
15MP0008007_abnormal_cellular_replicative1.91025729
16MP0002006_tumorigenesis1.87861183
17MP0005084_abnormal_gallbladder_morpholo1.85008119
18MP0004043_abnormal_pH_regulation1.82599070
19MP0005000_abnormal_immune_tolerance1.79383261
20MP0002876_abnormal_thyroid_physiology1.78555299
21MP0009764_decreased_sensitivity_to1.77991769
22MP0000685_abnormal_immune_system1.67318572
23MP0008877_abnormal_DNA_methylation1.63427873
24MP0005645_abnormal_hypothalamus_physiol1.61954083
25MP0002452_abnormal_antigen_presenting1.59178509
26MP0001968_abnormal_touch/_nociception1.55696984
27MP0002723_abnormal_immune_serum1.53735951
28MP0002102_abnormal_ear_morphology1.51069387
29MP0003436_decreased_susceptibility_to1.45160387
30MP0008775_abnormal_heart_ventricle1.44860508
31MP0002736_abnormal_nociception_after1.44243924
32MP0003646_muscle_fatigue1.42192295
33MP0003724_increased_susceptibility_to1.41299238
34MP0003763_abnormal_thymus_physiology1.39256282
35MP0005551_abnormal_eye_electrophysiolog1.38778257
36MP0003718_maternal_effect1.38204951
37MP0005253_abnormal_eye_physiology1.38069761
38MP0001819_abnormal_immune_cell1.35902089
39MP0002420_abnormal_adaptive_immunity1.34301686
40MP0004142_abnormal_muscle_tone1.32943447
41MP0004145_abnormal_muscle_electrophysio1.32291184
42MP0003786_premature_aging1.30162386
43MP0005389_reproductive_system_phenotype1.29516613
44MP0003252_abnormal_bile_duct1.29226571
45MP0010155_abnormal_intestine_physiology1.28678814
46MP0005167_abnormal_blood-brain_barrier1.25731916
47MP0004147_increased_porphyrin_level1.24827175
48MP0003866_abnormal_defecation1.23166614
49MP0005387_immune_system_phenotype1.23066000
50MP0001790_abnormal_immune_system1.23066000
51MP0001919_abnormal_reproductive_system1.22697574
52MP0008058_abnormal_DNA_repair1.20810765
53MP0002837_dystrophic_cardiac_calcinosis1.19253517
54MP0006292_abnormal_olfactory_placode1.19100975
55MP0003186_abnormal_redox_activity1.18110684
56MP0005410_abnormal_fertilization1.15628187
57MP0006036_abnormal_mitochondrial_physio1.14157839
58MP0001501_abnormal_sleep_pattern1.12111676
59MP0001845_abnormal_inflammatory_respons1.11332172
60MP0010386_abnormal_urinary_bladder1.06617291
61MP0000516_abnormal_urinary_system1.03680412
62MP0005367_renal/urinary_system_phenotyp1.03680412
63MP0004782_abnormal_surfactant_physiolog1.01631751
64MP0004215_abnormal_myocardial_fiber1.01322597
65MP0000716_abnormal_immune_system1.01187816
66MP0005075_abnormal_melanosome_morpholog1.00752200
67MP0004084_abnormal_cardiac_muscle1.00201200
68MP0005025_abnormal_response_to0.99426723
69MP0002398_abnormal_bone_marrow0.99401655
70MP0009697_abnormal_copulation0.99263400
71MP0001986_abnormal_taste_sensitivity0.99129898
72MP0000689_abnormal_spleen_morphology0.98130334
73MP0000230_abnormal_systemic_arterial0.95721163
74MP0000372_irregular_coat_pigmentation0.94817900
75MP0001764_abnormal_homeostasis0.93563374
76MP0005085_abnormal_gallbladder_physiolo0.93274813
77MP0001765_abnormal_ion_homeostasis0.93266398
78MP0005636_abnormal_mineral_homeostasis0.92213505
79MP0000465_gastrointestinal_hemorrhage0.91578351
80MP0003195_calcinosis0.91433188
81MP0002419_abnormal_innate_immunity0.90676173
82MP0000427_abnormal_hair_cycle0.90298092
83MP0008469_abnormal_protein_level0.89943928
84MP0006082_CNS_inflammation0.89669699
85MP0009333_abnormal_splenocyte_physiolog0.88366492
86MP0001905_abnormal_dopamine_level0.88250656
87MP0003045_fibrosis0.84413472
88MP0002405_respiratory_system_inflammati0.84393323
89MP0001881_abnormal_mammary_gland0.84347570
90MP0001529_abnormal_vocalization0.83250278
91MP0000013_abnormal_adipose_tissue0.82899576
92MP0005332_abnormal_amino_acid0.82452659
93MP0002254_reproductive_system_inflammat0.82159998
94MP0002160_abnormal_reproductive_system0.81323266
95MP0002429_abnormal_blood_cell0.80105824
96MP0004885_abnormal_endolymph0.77933964
97MP0002272_abnormal_nervous_system0.77349857
98MP0001663_abnormal_digestive_system0.77011935
99MP0001440_abnormal_grooming_behavior0.75521178
100MP0003303_peritoneal_inflammation0.74531590

Predicted human phenotypes

RankGene SetZ-score
1Congenital, generalized hypertrichosis (HP:0004540)4.43164113
2Acute necrotizing encephalopathy (HP:0006965)3.65324156
3Abolished electroretinogram (ERG) (HP:0000550)3.46836102
4Acute encephalopathy (HP:0006846)3.38441680
5Elevated erythrocyte sedimentation rate (HP:0003565)3.32689048
6Delayed CNS myelination (HP:0002188)3.30490991
7Mitochondrial inheritance (HP:0001427)3.30163724
8Pancreatic cysts (HP:0001737)3.29534956
9Increased CSF lactate (HP:0002490)3.28578520
10Progressive macrocephaly (HP:0004481)3.26463867
11Abnormality of the prostate (HP:0008775)3.16374733
12Hepatocellular necrosis (HP:0001404)3.15253668
13Abnormal mitochondria in muscle tissue (HP:0008316)3.13199156
14Hypoplasia of the uterus (HP:0000013)2.98601768
15Decreased electroretinogram (ERG) amplitude (HP:0000654)2.94142872
16IgG deficiency (HP:0004315)2.93861697
173-Methylglutaconic aciduria (HP:0003535)2.92325032
18Aplasia/hypoplasia of the uterus (HP:0008684)2.92055095
19Congenital stationary night blindness (HP:0007642)2.88609050
20Severe combined immunodeficiency (HP:0004430)2.87325699
21Attenuation of retinal blood vessels (HP:0007843)2.83054692
22Thyroiditis (HP:0100646)2.82203414
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.80455046
24Absent/shortened dynein arms (HP:0200106)2.80455046
25Hepatic necrosis (HP:0002605)2.77467384
26Decreased central vision (HP:0007663)2.75651166
27Absent rod-and cone-mediated responses on ERG (HP:0007688)2.71069494
28Fibular aplasia (HP:0002990)2.63306108
29Cerebral edema (HP:0002181)2.60552751
30Pancreatic fibrosis (HP:0100732)2.55607240
31Abnormal rod and cone electroretinograms (HP:0008323)2.51226772
32Lipid accumulation in hepatocytes (HP:0006561)2.50838855
33Increased serum lactate (HP:0002151)2.50761746
34Abnormality of the renal cortex (HP:0011035)2.50341408
35Molar tooth sign on MRI (HP:0002419)2.49794769
36Abnormality of midbrain morphology (HP:0002418)2.49794769
37Stomatitis (HP:0010280)2.49017895
38T lymphocytopenia (HP:0005403)2.41112753
39Abnormality of T cell number (HP:0011839)2.40443734
40Type II lissencephaly (HP:0007260)2.39198134
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.39146527
42Abnormality of alanine metabolism (HP:0010916)2.39146527
43Hyperalaninemia (HP:0003348)2.39146527
44Abnormality of the phalanges of the 2nd finger (HP:0009541)2.34770378
45Abnormality of T cell physiology (HP:0011840)2.34284150
46Polydipsia (HP:0001959)2.33891313
47Abnormal drinking behavior (HP:0030082)2.33891313
48Optic disc pallor (HP:0000543)2.32084890
49Abnormality of the proximal phalanges of the hand (HP:0009834)2.31800825
50Bile duct proliferation (HP:0001408)2.27347093
51Abnormal biliary tract physiology (HP:0012439)2.27347093
52Methylmalonic acidemia (HP:0002912)2.27337628
53Panhypogammaglobulinemia (HP:0003139)2.26557400
54Abnormality of secondary sexual hair (HP:0009888)2.25182607
55Abnormality of the axillary hair (HP:0100134)2.25182607
56Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.24899069
57Increased hepatocellular lipid droplets (HP:0006565)2.24858933
58Abnormality of eosinophils (HP:0001879)2.23493137
59Pendular nystagmus (HP:0012043)2.21611777
60Lactic acidosis (HP:0003128)2.21169118
61Abnormality of B cell number (HP:0010975)2.18105788
62Abnormality of T cells (HP:0002843)2.16955281
63Nephronophthisis (HP:0000090)2.16610276
64Renal cortical cysts (HP:0000803)2.14226598
65Combined immunodeficiency (HP:0005387)2.12613712
66Abnormality of the phalanges of the 5th finger (HP:0004213)2.03931274
67Abnormal ciliary motility (HP:0012262)2.03853186
68Prostate neoplasm (HP:0100787)2.02710445
69Lethargy (HP:0001254)2.02288145
70Abnormality of the renal medulla (HP:0100957)2.02045932
71Respiratory failure (HP:0002878)2.01513014
72Hyperglycinuria (HP:0003108)2.00495697
73Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99650261
74Dicarboxylic aciduria (HP:0003215)1.99650261
75True hermaphroditism (HP:0010459)1.98786241
76Type 2 muscle fiber atrophy (HP:0003554)1.97653080
77Retrobulbar optic neuritis (HP:0100654)1.92340193
78Optic neuritis (HP:0100653)1.92340193
79Hypothermia (HP:0002045)1.91512572
80Abnormality of the middle phalanges of the toes (HP:0010183)1.91473701
81Abnormal respiratory epithelium morphology (HP:0012253)1.89490227
82Abnormal respiratory motile cilium morphology (HP:0005938)1.89490227
83Agammaglobulinemia (HP:0004432)1.88576482
84Keratoconus (HP:0000563)1.88090377
85Increased corneal curvature (HP:0100692)1.88090377
86Thyroid-stimulating hormone excess (HP:0002925)1.86993481
87Opisthotonus (HP:0002179)1.82457784
88Testicular atrophy (HP:0000029)1.80900148
89Supernumerary spleens (HP:0009799)1.79539696
90Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.78655369
91Abnormality of male internal genitalia (HP:0000022)1.77691605
92Renal Fanconi syndrome (HP:0001994)1.77458018
93Chronic mucocutaneous candidiasis (HP:0002728)1.76922231
94Recurrent cutaneous fungal infections (HP:0011370)1.76922231
95Stomach cancer (HP:0012126)1.76519364
96Abnormal delayed hypersensitivity skin test (HP:0002963)1.75529027
97Polyuria (HP:0000103)1.75521516
98Aplasia/Hypoplasia of the spleen (HP:0010451)1.74291222
99IgM deficiency (HP:0002850)1.73946430
100Fair hair (HP:0002286)1.73468535

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K23.78472576
2TLK13.23794202
3TAOK33.22867699
4EIF2AK33.17577552
5ZAK3.04384064
6FRK3.02194636
7NUAK12.80761237
8TXK2.75881408
9KIT2.30991644
10WNK42.29324465
11ADRBK21.93618131
12OXSR11.90495900
13TIE11.84969349
14MST41.81191688
15CDK191.78852524
16GRK11.68389037
17BMPR1B1.61385060
18PLK21.58853549
19FES1.55205919
20VRK21.47930669
21EIF2AK21.47768291
22EIF2AK11.47370250
23CSF1R1.47101671
24BMPR21.43726928
25ACVR1B1.37714571
26TEC1.35957931
27STK161.34324151
28MAP3K141.26924242
29MAP4K11.22216773
30SRPK11.16937386
31SCYL21.16804652
32FLT31.16742232
33DAPK21.16633853
34MKNK11.16359365
35STK391.15580284
36IKBKB1.14533826
37BCKDK1.14279831
38SYK1.13934535
39ITK1.11202223
40DAPK11.10733044
41JAK31.08381594
42PHKG21.01430419
43PHKG11.01430419
44RPS6KA50.97240902
45RIPK40.94651594
46TNK20.93837825
47VRK10.92857644
48TBK10.91859387
49CSNK1G30.88928170
50GRK60.88692255
51CAMKK20.88282889
52ERBB30.88230743
53IKBKE0.87435958
54PINK10.86465757
55LYN0.82495312
56MAPKAPK50.82331213
57PLK30.81391990
58KDR0.78839479
59BCR0.78632897
60MATK0.74033104
61CSNK1G20.73743679
62BTK0.73725563
63INSRR0.73525843
64PIK3CG0.71916453
65TGFBR10.71097716
66ADRBK10.70316629
67CSNK1A1L0.68189399
68PRKCQ0.67418946
69LCK0.66916308
70MAPK130.63160626
71CSNK1G10.62321223
72MAPKAPK30.61146533
73DYRK20.60030794
74GRK70.56886053
75MKNK20.56845027
76PRKCE0.56790537
77MAP3K40.56678673
78ATR0.56319217
79NEK10.54153823
80GRK50.53796815
81TRPM70.52036596
82IGF1R0.50499812
83CHUK0.50016463
84TSSK60.49806113
85HCK0.49062147
86PLK40.48846201
87DAPK30.48807692
88NME10.46054171
89MAP2K60.43636795
90PRKCI0.40909776
91CLK10.39272790
92CAMKK10.39154235
93ILK0.35344968
94PRKG10.33568521
95PRKCA0.32529115
96JAK10.31479281
97OBSCN0.30193647
98PKN10.28549562
99ABL10.28513021
100PASK0.28211267

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.00625193
2Allograft rejection_Homo sapiens_hsa053303.90412171
3Intestinal immune network for IgA production_Homo sapiens_hsa046723.77779780
4Autoimmune thyroid disease_Homo sapiens_hsa053203.59814165
5Graft-versus-host disease_Homo sapiens_hsa053323.36283398
6Proteasome_Homo sapiens_hsa030503.10595701
7Type I diabetes mellitus_Homo sapiens_hsa049402.95118409
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.35884198
9Oxidative phosphorylation_Homo sapiens_hsa001902.35681581
10Caffeine metabolism_Homo sapiens_hsa002322.26062168
11Antigen processing and presentation_Homo sapiens_hsa046122.01395244
12Ribosome_Homo sapiens_hsa030101.89488235
13Parkinsons disease_Homo sapiens_hsa050121.86963662
14Protein export_Homo sapiens_hsa030601.84328641
15Primary immunodeficiency_Homo sapiens_hsa053401.72413140
16Rheumatoid arthritis_Homo sapiens_hsa053231.70934051
17Phototransduction_Homo sapiens_hsa047441.64752348
18Linoleic acid metabolism_Homo sapiens_hsa005911.60019767
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48252300
20Nitrogen metabolism_Homo sapiens_hsa009101.46853820
21RNA degradation_Homo sapiens_hsa030181.45046296
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42621190
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.40863588
24Propanoate metabolism_Homo sapiens_hsa006401.38310051
25Staphylococcus aureus infection_Homo sapiens_hsa051501.36703487
26One carbon pool by folate_Homo sapiens_hsa006701.34226616
27RNA polymerase_Homo sapiens_hsa030201.33152789
28Arachidonic acid metabolism_Homo sapiens_hsa005901.25289224
29Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.24881687
30Tryptophan metabolism_Homo sapiens_hsa003801.19797295
31Viral myocarditis_Homo sapiens_hsa054161.18890133
32Homologous recombination_Homo sapiens_hsa034401.14082667
33Alzheimers disease_Homo sapiens_hsa050101.13727672
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12324088
35Leishmaniasis_Homo sapiens_hsa051401.09531297
36Systemic lupus erythematosus_Homo sapiens_hsa053221.07159461
37Hematopoietic cell lineage_Homo sapiens_hsa046401.05636526
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04502851
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01780891
40Fanconi anemia pathway_Homo sapiens_hsa034601.01508137
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99551094
42Huntingtons disease_Homo sapiens_hsa050160.97461675
43Ether lipid metabolism_Homo sapiens_hsa005650.91349255
44Peroxisome_Homo sapiens_hsa041460.89664138
45Purine metabolism_Homo sapiens_hsa002300.87494371
46Mismatch repair_Homo sapiens_hsa034300.87373865
47Basal transcription factors_Homo sapiens_hsa030220.87372181
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86333102
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.85484217
50Olfactory transduction_Homo sapiens_hsa047400.85219514
51Cardiac muscle contraction_Homo sapiens_hsa042600.84993340
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79532501
53Chemical carcinogenesis_Homo sapiens_hsa052040.74704144
54RNA transport_Homo sapiens_hsa030130.73678454
55Nucleotide excision repair_Homo sapiens_hsa034200.72649736
56Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71406871
57Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70864307
58Pyrimidine metabolism_Homo sapiens_hsa002400.67821820
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65995681
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.62434133
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60730472
62DNA replication_Homo sapiens_hsa030300.59786607
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59587406
64Spliceosome_Homo sapiens_hsa030400.58995177
65Butanoate metabolism_Homo sapiens_hsa006500.58089054
66Fat digestion and absorption_Homo sapiens_hsa049750.57660564
67Regulation of autophagy_Homo sapiens_hsa041400.55651950
68Retinol metabolism_Homo sapiens_hsa008300.55434423
69Herpes simplex infection_Homo sapiens_hsa051680.54651265
70Fatty acid degradation_Homo sapiens_hsa000710.54546412
71Selenocompound metabolism_Homo sapiens_hsa004500.51970178
72Jak-STAT signaling pathway_Homo sapiens_hsa046300.50698824
73Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47715451
74Non-homologous end-joining_Homo sapiens_hsa034500.47214305
75Salivary secretion_Homo sapiens_hsa049700.47037432
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.46941430
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46147100
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45970988
79Base excision repair_Homo sapiens_hsa034100.45402797
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.44355357
81beta-Alanine metabolism_Homo sapiens_hsa004100.43990060
82Sulfur metabolism_Homo sapiens_hsa009200.43316419
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41199436
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40401831
85Metabolic pathways_Homo sapiens_hsa011000.38990664
86Epstein-Barr virus infection_Homo sapiens_hsa051690.37898844
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37594085
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.37552131
89Glutathione metabolism_Homo sapiens_hsa004800.36840691
90Cyanoamino acid metabolism_Homo sapiens_hsa004600.35078311
91Primary bile acid biosynthesis_Homo sapiens_hsa001200.33921722
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.33219858
93Tuberculosis_Homo sapiens_hsa051520.33212996
94Toxoplasmosis_Homo sapiens_hsa051450.30866286
95Morphine addiction_Homo sapiens_hsa050320.30012615
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27790358
97Collecting duct acid secretion_Homo sapiens_hsa049660.25646862
98Fatty acid metabolism_Homo sapiens_hsa012120.25359457
99Glycerolipid metabolism_Homo sapiens_hsa005610.25236850
100Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23600613

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