ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	6.10253628
2	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.66928329
3	ATP synthesis coupled proton transport (GO:0015986)	4.66928329
4	ribosomal small subunit assembly (GO:0000028)	4.54962041
5	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.43436291
6	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	4.24070022
7	cytidine metabolic process (GO:0046087)	3.77303193
8	cytidine catabolic process (GO:0006216)	3.77303193
9	cytidine deamination (GO:0009972)	3.77303193
10	ribosomal large subunit biogenesis (GO:0042273)	3.47344554
11	rRNA catabolic process (GO:0016075)	3.36101911
12	kynurenine metabolic process (GO:0070189)	3.31121761
13	tryptophan catabolic process (GO:0006569)	3.30812448
14	indole-containing compound catabolic process (GO:0042436)	3.30812448
15	indolalkylamine catabolic process (GO:0046218)	3.30812448
16	mast cell activation (GO:0045576)	3.30737170
17	viral transcription (GO:0019083)	3.16466760
18	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.15052243
19	pyrimidine ribonucleoside catabolic process (GO:0046133)	3.14720765
20	negative regulation of mast cell activation (GO:0033004)	3.13907374
21	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.13477258
22	ubiquinone biosynthetic process (GO:0006744)	3.12937462
23	electron transport chain (GO:0022900)	3.12829453
24	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.12803518
25	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.11293825
26	respiratory electron transport chain (GO:0022904)	3.11205513
27	positive regulation of defense response to virus by host (GO:0002230)	3.09559816
28	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.08477993
29	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.08477993
30	water-soluble vitamin biosynthetic process (GO:0042364)	3.06527927
31	protein complex biogenesis (GO:0070271)	3.04874302
32	regulation of regulatory T cell differentiation (GO:0045589)	3.04838441
33	translational termination (GO:0006415)	3.03056480
34	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.99311546
35	preassembly of GPI anchor in ER membrane (GO:0016254)	2.99000920
36	S-adenosylmethionine metabolic process (GO:0046500)	2.96644926
37	behavioral response to nicotine (GO:0035095)	2.92851490
38	translational elongation (GO:0006414)	2.92583824
39	platelet dense granule organization (GO:0060155)	2.92511907
40	mast cell degranulation (GO:0043303)	2.90735680
41	mast cell activation involved in immune response (GO:0002279)	2.90735680
42	respiratory chain complex IV assembly (GO:0008535)	2.89263278
43	maturation of 5.8S rRNA (GO:0000460)	2.87745636
44	rRNA modification (GO:0000154)	2.86593753
45	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	2.86571817
46	positive regulation of T cell mediated cytotoxicity (GO:0001916)	2.85687837
47	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.85313263
48	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.85313263
49	NADH dehydrogenase complex assembly (GO:0010257)	2.85313263
50	fucose catabolic process (GO:0019317)	2.82811695
51	L-fucose metabolic process (GO:0042354)	2.82811695
52	L-fucose catabolic process (GO:0042355)	2.82811695
53	positive regulation of prostaglandin secretion (GO:0032308)	2.82665994
54	piRNA metabolic process (GO:0034587)	2.81976947
55	cellular response to interleukin-15 (GO:0071350)	2.81087134
56	protein-cofactor linkage (GO:0018065)	2.80498858
57	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	2.79118373
58	mitochondrial respiratory chain complex assembly (GO:0033108)	2.78964981
59	tryptophan metabolic process (GO:0006568)	2.77777394
60	proteasome assembly (GO:0043248)	2.77566143
61	response to interferon-beta (GO:0035456)	2.75933332
62	indolalkylamine metabolic process (GO:0006586)	2.74629629
63	regulation of germinal center formation (GO:0002634)	2.73374611
64	cotranslational protein targeting to membrane (GO:0006613)	2.72349578
65	positive thymic T cell selection (GO:0045059)	2.70584880
66	immunoglobulin mediated immune response (GO:0016064)	2.70521864
67	protein targeting to ER (GO:0045047)	2.69656192
68	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	2.68610450
69	negative regulation of telomere maintenance (GO:0032205)	2.66123212
70	regulation of T cell mediated cytotoxicity (GO:0001914)	2.65986561
71	base-excision repair, AP site formation (GO:0006285)	2.64928448
72	maturation of SSU-rRNA (GO:0030490)	2.64610634
73	positive regulation of protein homodimerization activity (GO:0090073)	2.64429811
74	somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	2.64286728
75	somatic diversification of immunoglobulins involved in immune response (GO:0002208)	2.64286728
76	isotype switching (GO:0045190)	2.64286728
77	ubiquinone metabolic process (GO:0006743)	2.63937233
78	cytochrome complex assembly (GO:0017004)	2.63822153
79	positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)	2.61851681
80	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.61162648
81	positive regulation of T cell differentiation in thymus (GO:0033089)	2.60706882
82	GPI anchor metabolic process (GO:0006505)	2.60105216
83	ncRNA catabolic process (GO:0034661)	2.58528992
84	quinone biosynthetic process (GO:1901663)	2.57485876
85	protein localization to endoplasmic reticulum (GO:0070972)	2.57479364
86	positive T cell selection (GO:0043368)	2.57044690
87	ATP biosynthetic process (GO:0006754)	2.55403871
88	regulation of cellular amino acid metabolic process (GO:0006521)	2.54721776
89	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.54111239
90	regulation of chronic inflammatory response (GO:0002676)	2.53529189
91	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.52733893
92	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.51541120
93	B cell mediated immunity (GO:0019724)	2.50972176
94	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.50884434
95	protein neddylation (GO:0045116)	2.49036592
96	GPI anchor biosynthetic process (GO:0006506)	2.48956655
97	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.48952415
98	termination of RNA polymerase III transcription (GO:0006386)	2.48746855
99	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.48746855
100	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48591694

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.38673795
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.59298554
3	VDR_22108803_ChIP-Seq_LS180_Human	3.51085864
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.45743001
5	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.04339050
6	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.03393743
7	ZNF274_21170338_ChIP-Seq_K562_Hela	2.99158719
8	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75238298
9	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.63969517
10	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.48602418
11	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.46989716
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.46542931
13	VDR_23849224_ChIP-Seq_CD4+_Human	2.41690301
14	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.39377618
15	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	2.28808992
16	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.27829384
17	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.27104329
18	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	2.24786119
19	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.08727422
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.99175177
21	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96657856
22	ELK1_19687146_ChIP-ChIP_HELA_Human	1.95774644
23	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.85706371
24	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.84972304
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.84574025
26	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77028033
27	EWS_26573619_Chip-Seq_HEK293_Human	1.75499687
28	GATA3_26560356_Chip-Seq_TH2_Human	1.69673825
29	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.62009698
30	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.61445392
31	EZH2_22144423_ChIP-Seq_EOC_Human	1.55582991
32	TP53_22573176_ChIP-Seq_HFKS_Human	1.55438023
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.55229837
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.54709817
35	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.53625869
36	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.53625869
37	AR_20517297_ChIP-Seq_VCAP_Human	1.52866671
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.50086765
39	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.49051901
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.42203331
41	ER_23166858_ChIP-Seq_MCF-7_Human	1.38628046
42	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.38322448
43	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37475697
44	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.34847662
45	MYB_26560356_Chip-Seq_TH2_Human	1.31174656
46	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.30141184
47	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.29784359
48	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.29358442
49	FUS_26573619_Chip-Seq_HEK293_Human	1.28576288
50	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.28148246
51	RUNX_20019798_ChIP-Seq_JUKART_Human	1.27427338
52	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.27355619
53	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25479513
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25100814
55	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.24532912
56	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23271513
57	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.22722895
58	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.22462857
59	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20667650
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20667650
61	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.20139180
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.19499684
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.19499684
64	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.19407520
65	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.18071583
66	NANOG_20526341_ChIP-Seq_ESCs_Human	1.17636374
67	NCOR_22424771_ChIP-Seq_293T_Human	1.16801183
68	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.16504000
69	P300_19829295_ChIP-Seq_ESCs_Human	1.15836935
70	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.14599690
71	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.13495658
72	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12430948
73	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12222520
74	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.10235171
75	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.10089249
76	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.10077977
77	GATA3_27048872_Chip-Seq_THYMUS_Human	1.09837454
78	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09609035
79	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.09107561
80	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09104692
81	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.08157168
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.07842529
83	TAF15_26573619_Chip-Seq_HEK293_Human	1.06017307
84	STAT1_20625510_ChIP-Seq_HELA_Human	1.04907859
85	HOXB7_26014856_ChIP-Seq_BT474_Human	1.04708973
86	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.03441309
87	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.00583533
88	GATA3_26560356_Chip-Seq_TH1_Human	1.00364047
89	GBX2_23144817_ChIP-Seq_PC3_Human	1.00026525
90	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.99326430
91	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99233530
92	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.98854023
93	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.98016133
94	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.97257241
95	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.95586675
96	ERG_20517297_ChIP-Seq_VCAP_Human	0.93148939
97	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.92787731
98	ERA_21632823_ChIP-Seq_H3396_Human	0.91075513
99	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.91010218
100	CIITA_25753668_ChIP-Seq_RAJI_Human	0.90461964

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005671_abnormal_response_to	4.51486146
2	MP0001835_abnormal_antigen_presentation	3.38473105
3	MP0006072_abnormal_retinal_apoptosis	2.35787969
4	MP0002138_abnormal_hepatobiliary_system	2.34474724
5	MP0000685_abnormal_immune_system	2.28593795
6	MP0003646_muscle_fatigue	2.25152148
7	MP0004147_increased_porphyrin_level	2.22652872
8	MP0009785_altered_susceptibility_to	2.13284883
9	MP0005645_abnormal_hypothalamus_physiol	2.13073830
10	MP0002876_abnormal_thyroid_physiology	2.08248961
11	MP0002166_altered_tumor_susceptibility	2.07333272
12	MP0002102_abnormal_ear_morphology	2.06057123
13	MP0004885_abnormal_endolymph	2.05319541
14	MP0001800_abnormal_humoral_immune	2.04925311
15	MP0005000_abnormal_immune_tolerance	2.03535591
16	MP0009379_abnormal_foot_pigmentation	2.00656185
17	MP0008872_abnormal_physiological_respon	1.98275781
18	MP0002148_abnormal_hypersensitivity_rea	1.97490206
19	MP0001968_abnormal_touch/_nociception	1.92311959
20	MP0005075_abnormal_melanosome_morpholog	1.87495407
21	MP0001986_abnormal_taste_sensitivity	1.87235418
22	MP0008877_abnormal_DNA_methylation	1.81416334
23	MP0002006_tumorigenesis	1.80184842
24	MP0008875_abnormal_xenobiotic_pharmacok	1.79325756
25	MP0002837_dystrophic_cardiac_calcinosis	1.79102543
26	MP0005646_abnormal_pituitary_gland	1.76743057
27	MP0009764_decreased_sensitivity_to	1.74512962
28	MP0005377_hearing/vestibular/ear_phenot	1.69578377
29	MP0003878_abnormal_ear_physiology	1.69578377
30	MP0000372_irregular_coat_pigmentation	1.68295241
31	MP0002723_abnormal_immune_serum	1.68014696
32	MP0006292_abnormal_olfactory_placode	1.66008365
33	MP0002736_abnormal_nociception_after	1.64785452
34	MP0003763_abnormal_thymus_physiology	1.63618776
35	MP0005551_abnormal_eye_electrophysiolog	1.62179325
36	MP0003806_abnormal_nucleotide_metabolis	1.57703309
37	MP0001790_abnormal_immune_system	1.56699162
38	MP0005387_immune_system_phenotype	1.56699162
39	MP0001501_abnormal_sleep_pattern	1.53815480
40	MP0002452_abnormal_antigen_presenting	1.52652864
41	MP0003436_decreased_susceptibility_to	1.51885397
42	MP0003724_increased_susceptibility_to	1.49750556
43	MP0001819_abnormal_immune_cell	1.46425051
44	MP0002420_abnormal_adaptive_immunity	1.45789473
45	MP0009333_abnormal_splenocyte_physiolog	1.40276588
46	MP0010155_abnormal_intestine_physiology	1.37080466
47	MP0003011_delayed_dark_adaptation	1.33283427
48	MP0003866_abnormal_defecation	1.29845574
49	MP0005253_abnormal_eye_physiology	1.28530916
50	MP0008058_abnormal_DNA_repair	1.25032662
51	MP0006036_abnormal_mitochondrial_physio	1.24572028
52	MP0001873_stomach_inflammation	1.20076999
53	MP0008995_early_reproductive_senescence	1.19620457
54	MP0005025_abnormal_response_to	1.18387676
55	MP0000569_abnormal_digit_pigmentation	1.17465859
56	MP0002095_abnormal_skin_pigmentation	1.10840156
57	MP0002272_abnormal_nervous_system	1.08863630
58	MP0000716_abnormal_immune_system	1.06179085
59	MP0005174_abnormal_tail_pigmentation	1.02960828
60	MP0005085_abnormal_gallbladder_physiolo	1.02911466
61	MP0001765_abnormal_ion_homeostasis	1.01965554
62	MP0002398_abnormal_bone_marrow	1.01956660
63	MP0005084_abnormal_gallbladder_morpholo	1.01406539
64	MP0001845_abnormal_inflammatory_respons	1.01030041
65	MP0003195_calcinosis	1.00593495
66	MP0003786_premature_aging	1.00148856
67	MP0004142_abnormal_muscle_tone	0.98728813
68	MP0002405_respiratory_system_inflammati	0.98571174
69	MP0003718_maternal_effect	0.98450415
70	MP0001905_abnormal_dopamine_level	0.97446103
71	MP0000689_abnormal_spleen_morphology	0.96970491
72	MP0005167_abnormal_blood-brain_barrier	0.96720472
73	MP0005636_abnormal_mineral_homeostasis	0.95284630
74	MP0006035_abnormal_mitochondrial_morpho	0.93096850
75	MP0008775_abnormal_heart_ventricle	0.92488006
76	MP0001533_abnormal_skeleton_physiology	0.92295658
77	MP0002277_abnormal_respiratory_mucosa	0.91207893
78	MP0008007_abnormal_cellular_replicative	0.89351730
79	MP0000427_abnormal_hair_cycle	0.85624267
80	MP0001919_abnormal_reproductive_system	0.85472730
81	MP0003880_abnormal_central_pattern	0.85399869
82	MP0004145_abnormal_muscle_electrophysio	0.85088844
83	MP0002419_abnormal_innate_immunity	0.83426372
84	MP0002254_reproductive_system_inflammat	0.81485374
85	MP0009745_abnormal_behavioral_response	0.81339459
86	MP0005389_reproductive_system_phenotype	0.81032369
87	MP0004381_abnormal_hair_follicle	0.80827883
88	MP0001440_abnormal_grooming_behavior	0.78987521
89	MP0003638_abnormal_response/metabolism_	0.77815452
90	MP0002429_abnormal_blood_cell	0.77055439
91	MP0001970_abnormal_pain_threshold	0.76949265
92	MP0008469_abnormal_protein_level	0.76210301
93	MP0002722_abnormal_immune_system	0.76077974
94	MP0001486_abnormal_startle_reflex	0.75051735
95	MP0002234_abnormal_pharynx_morphology	0.73178042
96	MP0005410_abnormal_fertilization	0.72783928
97	MP0001853_heart_inflammation	0.72006022
98	MP0000703_abnormal_thymus_morphology	0.71284042
99	MP0002638_abnormal_pupillary_reflex	0.68467142
100	MP0009046_muscle_twitch	0.67073619

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	3.97061062
2	Congenital, generalized hypertrichosis (HP:0004540)	3.79760177
3	IgG deficiency (HP:0004315)	3.78443720
4	Congenital stationary night blindness (HP:0007642)	3.73315002
5	Pancreatic fibrosis (HP:0100732)	3.44754280
6	Acute necrotizing encephalopathy (HP:0006965)	3.31965857
7	Elevated erythrocyte sedimentation rate (HP:0003565)	3.30378546
8	3-Methylglutaconic aciduria (HP:0003535)	3.22169283
9	Abnormality of the renal cortex (HP:0011035)	3.18968798
10	Stomatitis (HP:0010280)	3.17772760
11	True hermaphroditism (HP:0010459)	3.15965960
12	Molar tooth sign on MRI (HP:0002419)	3.13993589
13	Abnormality of midbrain morphology (HP:0002418)	3.13993589
14	Mitochondrial inheritance (HP:0001427)	3.13814914
15	Hepatocellular necrosis (HP:0001404)	3.04078032
16	Increased CSF lactate (HP:0002490)	2.99688964
17	Abnormal rod and cone electroretinograms (HP:0008323)	2.94014297
18	Abolished electroretinogram (ERG) (HP:0000550)	2.93288172
19	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.92619516
20	Acute encephalopathy (HP:0006846)	2.91020297
21	Abnormal mitochondria in muscle tissue (HP:0008316)	2.90854108
22	Stomach cancer (HP:0012126)	2.86837808
23	Hepatic necrosis (HP:0002605)	2.82659858
24	Severe combined immunodeficiency (HP:0004430)	2.82112072
25	Progressive macrocephaly (HP:0004481)	2.81847646
26	Renal cortical cysts (HP:0000803)	2.81807294
27	Abnormality of the prostate (HP:0008775)	2.79439286
28	Abnormality of B cell number (HP:0010975)	2.76696755
29	Hypoproteinemia (HP:0003075)	2.65392420
30	Thyroiditis (HP:0100646)	2.58018525
31	Bile duct proliferation (HP:0001408)	2.52422234
32	Abnormal biliary tract physiology (HP:0012439)	2.52422234
33	Increased serum lactate (HP:0002151)	2.49880123
34	Abnormality of eosinophils (HP:0001879)	2.49661335
35	Asplenia (HP:0001746)	2.49465870
36	Abnormal number of erythroid precursors (HP:0012131)	2.49396205
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.47442033
38	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.47442033
39	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.46724607
40	Increased hepatocellular lipid droplets (HP:0006565)	2.46643216
41	Lipid accumulation in hepatocytes (HP:0006561)	2.42492804
42	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.40830075
43	Nephronophthisis (HP:0000090)	2.40515949
44	Attenuation of retinal blood vessels (HP:0007843)	2.40498510
45	Abnormality of cells of the erythroid lineage (HP:0012130)	2.36546468
46	Optic disc pallor (HP:0000543)	2.36442609
47	Type II lissencephaly (HP:0007260)	2.36007164
48	Abnormality of the renal medulla (HP:0100957)	2.32868427
49	Cystic liver disease (HP:0006706)	2.32206997
50	Abnormality of T cell number (HP:0011839)	2.24042827
51	Hypothermia (HP:0002045)	2.21850749
52	Increased IgM level (HP:0003496)	2.21432776
53	Decreased central vision (HP:0007663)	2.20734378
54	Lactic acidosis (HP:0003128)	2.19165382
55	Prostate neoplasm (HP:0100787)	2.18968454
56	Increased intramyocellular lipid droplets (HP:0012240)	2.17052648
57	Abnormality of T cells (HP:0002843)	2.15817231
58	Autoimmune hemolytic anemia (HP:0001890)	2.15329367
59	Eosinophilia (HP:0001880)	2.13429582
60	Cerebral edema (HP:0002181)	2.12688140
61	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.12209558
62	Autoimmune thrombocytopenia (HP:0001973)	2.09784739
63	Absent/shortened dynein arms (HP:0200106)	2.09029142
64	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.09029142
65	Polydipsia (HP:0001959)	2.09011963
66	Abnormal drinking behavior (HP:0030082)	2.09011963
67	Methylmalonic acidemia (HP:0002912)	2.07683761
68	Pendular nystagmus (HP:0012043)	2.05203703
69	Hypokalemic alkalosis (HP:0001949)	2.04661022
70	Combined immunodeficiency (HP:0005387)	2.03136031
71	Reduced antithrombin III activity (HP:0001976)	2.02437421
72	Polyuria (HP:0000103)	2.02350766
73	T lymphocytopenia (HP:0005403)	2.01116644
74	Abnormality of T cell physiology (HP:0011840)	1.99324932
75	Pustule (HP:0200039)	1.97957453
76	Sclerocornea (HP:0000647)	1.97007638
77	Metabolic alkalosis (HP:0200114)	1.95695505
78	Absent thumb (HP:0009777)	1.95563425
79	B lymphocytopenia (HP:0010976)	1.94511224
80	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	1.93237420
81	Constricted visual fields (HP:0001133)	1.90476753
82	Generalized aminoaciduria (HP:0002909)	1.90066470
83	Dyschromatopsia (HP:0007641)	1.89059526
84	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.88118918
85	Hypoplasia of the fovea (HP:0007750)	1.88118918
86	Testicular atrophy (HP:0000029)	1.86953448
87	Panhypogammaglobulinemia (HP:0003139)	1.86287140
88	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.86076526
89	Type I transferrin isoform profile (HP:0003642)	1.85411333
90	Myositis (HP:0100614)	1.85404936
91	Increased muscle lipid content (HP:0009058)	1.85149228
92	Congenital hepatic fibrosis (HP:0002612)	1.84445465
93	Keratoconus (HP:0000563)	1.84405072
94	Increased corneal curvature (HP:0100692)	1.84405072
95	Anencephaly (HP:0002323)	1.82392865
96	Abnormality of the pons (HP:0007361)	1.81147858
97	Lethargy (HP:0001254)	1.80210900
98	Abnormality of alanine metabolism (HP:0010916)	1.76298403
99	Hyperalaninemia (HP:0003348)	1.76298403
100	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.76298403

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.87857237
2	TXK	3.85432883
3	TLK1	3.45430273
4	TAOK3	3.12895010
5	CDK19	2.70814342
6	FRK	2.63198020
7	NUAK1	2.46983965
8	STK16	2.46081872
9	ADRBK2	2.27352161
10	MAP4K2	2.14278686
11	KIT	2.13622205
12	MAP4K1	2.02047002
13	GRK1	1.95150455
14	VRK2	1.92865486
15	BMPR2	1.91878083
16	PINK1	1.84407131
17	BCKDK	1.82541934
18	WNK4	1.73464824
19	GRK6	1.72182467
20	MAPKAPK3	1.57632130
21	MST4	1.57533280
22	SYK	1.51131042
23	NME1	1.50406191
24	IKBKB	1.48618562
25	MAP3K12	1.43868455
26	MAP3K14	1.37379345
27	EIF2AK3	1.36718047
28	ITK	1.36545984
29	FES	1.36041535
30	CAMKK2	1.33236562
31	VRK1	1.31820488
32	KDR	1.30976449
33	PASK	1.26806600
34	OXSR1	1.21632276
35	TEC	1.20833376
36	FLT3	1.16568612
37	RIPK4	1.14285205
38	CSF1R	1.09661060
39	TIE1	1.06769752
40	MYLK	1.06245041
41	WNK3	1.05354291
42	MUSK	1.02970348
43	DAPK2	0.96226655
44	DAPK1	0.90984536
45	PHKG1	0.90699714
46	PHKG2	0.90699714
47	TRPM7	0.90474296
48	LYN	0.89538339
49	JAK3	0.89418419
50	PIK3CA	0.87789685
51	CAMKK1	0.87266893
52	BTK	0.83952633
53	MAP2K6	0.82388558
54	EIF2AK2	0.76464686
55	INSRR	0.76392155
56	BUB1	0.76197238
57	LCK	0.73288729
58	IGF1R	0.73228716
59	IKBKE	0.72416873
60	TRIM28	0.70795457
61	PRKCE	0.66735783
62	PRKCQ	0.64312836
63	RPS6KA5	0.62747328
64	MATK	0.62508173
65	MAPK13	0.61510294
66	PLK2	0.61087588
67	NEK1	0.61084548
68	BMPR1B	0.60925911
69	SRPK1	0.60229620
70	EPHA3	0.59925568
71	ADRBK1	0.59047360
72	ERBB3	0.57543185
73	DYRK2	0.57095225
74	IRAK1	0.56387537
75	HCK	0.54378034
76	STK39	0.52672374
77	OBSCN	0.52000670
78	GRK7	0.49582825
79	DAPK3	0.48467365
80	EIF2AK1	0.47159993
81	PLK3	0.47033324
82	TBK1	0.45552780
83	MAPKAPK5	0.44291949
84	GRK5	0.43333806
85	MAP2K2	0.42673075
86	ACVR1B	0.42530259
87	PRKCA	0.41251099
88	CSNK1G3	0.40410634
89	PIK3CG	0.39648756
90	CHUK	0.39387531
91	TNK2	0.38868475
92	MAPK7	0.34835007
93	CSNK1G2	0.33391271
94	PRKACA	0.33232582
95	ABL1	0.31973673
96	PRKCG	0.31133063
97	CHEK2	0.30290776
98	PRKCD	0.30253192
99	TGFBR1	0.29837776
100	PRKG1	0.28838099

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.33206162
2	Allograft rejection_Homo sapiens_hsa05330	3.63121205
3	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.45975217
4	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.42704243
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.26447518
6	Proteasome_Homo sapiens_hsa03050	3.01380549
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.97066190
8	Ribosome_Homo sapiens_hsa03010	2.82305325
9	Primary immunodeficiency_Homo sapiens_hsa05340	2.62373022
10	Oxidative phosphorylation_Homo sapiens_hsa00190	2.59756054
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.21261094
12	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.19439839
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.11679313
14	Parkinsons disease_Homo sapiens_hsa05012	2.04850294
15	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.81556130
16	RNA polymerase_Homo sapiens_hsa03020	1.75982397
17	Rheumatoid arthritis_Homo sapiens_hsa05323	1.74767592
18	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.60789914
19	Protein export_Homo sapiens_hsa03060	1.58780794
20	Phototransduction_Homo sapiens_hsa04744	1.56916988
21	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45174106
22	RNA degradation_Homo sapiens_hsa03018	1.40627057
23	Nitrogen metabolism_Homo sapiens_hsa00910	1.36204707
24	Viral myocarditis_Homo sapiens_hsa05416	1.33164929
25	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.31022962
26	Alzheimers disease_Homo sapiens_hsa05010	1.28123483
27	One carbon pool by folate_Homo sapiens_hsa00670	1.27012335
28	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.25462589
29	Homologous recombination_Homo sapiens_hsa03440	1.20142943
30	Huntingtons disease_Homo sapiens_hsa05016	1.19026962
31	Caffeine metabolism_Homo sapiens_hsa00232	1.18688475
32	Tryptophan metabolism_Homo sapiens_hsa00380	1.16465230
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.15936565
34	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.15245536
35	Cardiac muscle contraction_Homo sapiens_hsa04260	1.12567880
36	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.10756584
37	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.07959134
38	Propanoate metabolism_Homo sapiens_hsa00640	1.04364696
39	Fanconi anemia pathway_Homo sapiens_hsa03460	1.04311427
40	Leishmaniasis_Homo sapiens_hsa05140	1.00136575
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.99398948
42	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94010947
43	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.91353115
44	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.90597582
45	Selenocompound metabolism_Homo sapiens_hsa00450	0.89200437
46	Mismatch repair_Homo sapiens_hsa03430	0.86995449
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.85912602
48	Olfactory transduction_Homo sapiens_hsa04740	0.84631769
49	Purine metabolism_Homo sapiens_hsa00230	0.84134194
50	Ether lipid metabolism_Homo sapiens_hsa00565	0.82044726
51	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82013449
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.79304212
53	Pyrimidine metabolism_Homo sapiens_hsa00240	0.67473872
54	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66017269
55	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.65600779
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.64678934
57	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.64086284
58	Retinol metabolism_Homo sapiens_hsa00830	0.63975104
59	Basal transcription factors_Homo sapiens_hsa03022	0.63877547
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.63787315
61	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.63275328
62	Spliceosome_Homo sapiens_hsa03040	0.62183485
63	Non-homologous end-joining_Homo sapiens_hsa03450	0.61244111
64	Butanoate metabolism_Homo sapiens_hsa00650	0.60968160
65	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.60692272
66	Fat digestion and absorption_Homo sapiens_hsa04975	0.60570301
67	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.60047589
68	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.59632506
69	Peroxisome_Homo sapiens_hsa04146	0.58206286
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.56223661
71	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.55351217
72	RNA transport_Homo sapiens_hsa03013	0.54753928
73	Regulation of autophagy_Homo sapiens_hsa04140	0.54532909
74	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53406671
75	Herpes simplex infection_Homo sapiens_hsa05168	0.49970204
76	DNA replication_Homo sapiens_hsa03030	0.49592597
77	Sulfur metabolism_Homo sapiens_hsa00920	0.47373954
78	Base excision repair_Homo sapiens_hsa03410	0.47134464
79	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.46779812
80	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46062665
81	Collecting duct acid secretion_Homo sapiens_hsa04966	0.45061084
82	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43041432
83	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.40638897
84	Metabolic pathways_Homo sapiens_hsa01100	0.40187683
85	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.38686708
86	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.36832960
87	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.35634657
88	Morphine addiction_Homo sapiens_hsa05032	0.35032490
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33344401
90	Taste transduction_Homo sapiens_hsa04742	0.31015861
91	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.30988684
92	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.30386654
93	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27844510
94	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.27654634
95	Nicotine addiction_Homo sapiens_hsa05033	0.26310674
96	Glycerolipid metabolism_Homo sapiens_hsa00561	0.25849364
97	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.25794971
98	Pyruvate metabolism_Homo sapiens_hsa00620	0.25374819
99	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.24991738
100	Toxoplasmosis_Homo sapiens_hsa05145	0.24440485

RPL7P37

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »