ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	DNA deamination (GO:0045006)	5.86706791
2	ribosomal small subunit assembly (GO:0000028)	5.46681752
3	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.58670194
4	ATP synthesis coupled proton transport (GO:0015986)	4.58670194
5	cornea development in camera-type eye (GO:0061303)	4.46798076
6	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	4.29674861
7	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	4.29674861
8	water-soluble vitamin biosynthetic process (GO:0042364)	4.10209619
9	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.97261074
10	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.95383587
11	viral transcription (GO:0019083)	3.84950962
12	ribosomal large subunit biogenesis (GO:0042273)	3.74229829
13	translational termination (GO:0006415)	3.70222057
14	behavioral response to nicotine (GO:0035095)	3.67413500
15	kynurenine metabolic process (GO:0070189)	3.60833340
16	maturation of SSU-rRNA (GO:0030490)	3.59250184
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.46975002
18	protein complex biogenesis (GO:0070271)	3.46809813
19	translational elongation (GO:0006414)	3.41929561
20	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.36042190
21	chaperone-mediated protein transport (GO:0072321)	3.35126592
22	indole-containing compound catabolic process (GO:0042436)	3.33490854
23	indolalkylamine catabolic process (GO:0046218)	3.33490854
24	tryptophan catabolic process (GO:0006569)	3.33490854
25	cotranslational protein targeting to membrane (GO:0006613)	3.32232453
26	protein targeting to ER (GO:0045047)	3.30393006
27	positive regulation of prostaglandin secretion (GO:0032308)	3.28331188
28	cytidine metabolic process (GO:0046087)	3.27578610
29	cytidine catabolic process (GO:0006216)	3.27578610
30	cytidine deamination (GO:0009972)	3.27578610
31	positive regulation of cell fate commitment (GO:0010455)	3.27258749
32	positive regulation of defense response to virus by host (GO:0002230)	3.20391508
33	protein localization to endoplasmic reticulum (GO:0070972)	3.18858007
34	regulation of cilium movement (GO:0003352)	3.16278502
35	protein neddylation (GO:0045116)	3.14697859
36	response to interferon-beta (GO:0035456)	3.13769929
37	electron transport chain (GO:0022900)	3.12125210
38	establishment of protein localization to endoplasmic reticulum (GO:0072599)	3.11748806
39	mitochondrial respiratory chain complex assembly (GO:0033108)	3.11288574
40	respiratory electron transport chain (GO:0022904)	3.10498528
41	fucose catabolic process (GO:0019317)	3.09083379
42	L-fucose metabolic process (GO:0042354)	3.09083379
43	L-fucose catabolic process (GO:0042355)	3.09083379
44	ribosomal small subunit biogenesis (GO:0042274)	3.08234633
45	preassembly of GPI anchor in ER membrane (GO:0016254)	3.08123762
46	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05291997
47	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05291997
48	NADH dehydrogenase complex assembly (GO:0010257)	3.05291997
49	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.97114694
50	cellular response to interferon-beta (GO:0035458)	2.94989303
51	positive regulation of respiratory burst (GO:0060267)	2.93627343
52	piRNA metabolic process (GO:0034587)	2.92381269
53	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.92199875
54	ubiquinone biosynthetic process (GO:0006744)	2.91955521
55	tryptophan metabolic process (GO:0006568)	2.88249759
56	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.83124067
57	viral life cycle (GO:0019058)	2.80312293
58	pyrimidine ribonucleoside catabolic process (GO:0046133)	2.77979957
59	indolalkylamine metabolic process (GO:0006586)	2.77488389
60	negative regulation of telomere maintenance (GO:0032205)	2.76472734
61	regulation of immunoglobulin secretion (GO:0051023)	2.74179891
62	regulation of regulatory T cell differentiation (GO:0045589)	2.72733917
63	platelet dense granule organization (GO:0060155)	2.72313112
64	immunoglobulin mediated immune response (GO:0016064)	2.71104296
65	mannosylation (GO:0097502)	2.70977058
66	somite development (GO:0061053)	2.70429248
67	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.70248381
68	cellular response to exogenous dsRNA (GO:0071360)	2.69325665
69	cytochrome complex assembly (GO:0017004)	2.68500999
70	translation (GO:0006412)	2.65880898
71	aldehyde catabolic process (GO:0046185)	2.65805717
72	translational initiation (GO:0006413)	2.65400522
73	regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	2.64618640
74	cellular biogenic amine catabolic process (GO:0042402)	2.64569388
75	amine catabolic process (GO:0009310)	2.64569388
76	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.63207114
77	parturition (GO:0007567)	2.62918717
78	GTP biosynthetic process (GO:0006183)	2.62774251
79	protein polyglutamylation (GO:0018095)	2.62620340
80	cellular protein complex disassembly (GO:0043624)	2.62384766
81	positive thymic T cell selection (GO:0045059)	2.60803380
82	maturation of 5.8S rRNA (GO:0000460)	2.60470150
83	positive regulation of fatty acid transport (GO:2000193)	2.59371791
84	mast cell activation involved in immune response (GO:0002279)	2.58883278
85	mast cell degranulation (GO:0043303)	2.58883278
86	respiratory chain complex IV assembly (GO:0008535)	2.56959127
87	GPI anchor metabolic process (GO:0006505)	2.54697890
88	GPI anchor biosynthetic process (GO:0006506)	2.54561561
89	aggressive behavior (GO:0002118)	2.53050930
90	hydrogen ion transmembrane transport (GO:1902600)	2.50225773
91	positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	2.50135409
92	ubiquinone metabolic process (GO:0006743)	2.48835940
93	mast cell activation (GO:0045576)	2.46769897
94	proteasome assembly (GO:0043248)	2.46679439
95	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.45287578
96	cellular component biogenesis (GO:0044085)	2.45131215
97	quinone biosynthetic process (GO:1901663)	2.44368625
98	proton transport (GO:0015992)	2.44216584
99	regulation of prostaglandin secretion (GO:0032306)	2.43647301
100	regulation of timing of cell differentiation (GO:0048505)	2.43085431

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.45898540
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.90329697
3	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.31371731
4	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.12912708
5	ZNF274_21170338_ChIP-Seq_K562_Hela	3.10725115
6	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	3.02881115
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.01745461
8	BP1_19119308_ChIP-ChIP_Hs578T_Human	2.78437961
9	VDR_22108803_ChIP-Seq_LS180_Human	2.72478264
10	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.70023500
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.59012533
12	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	2.41364909
13	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.31432155
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.10855095
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.10705007
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.02402414
17	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93946150
18	TP53_22573176_ChIP-Seq_HFKS_Human	1.93570850
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.77777782
20	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75497694
21	MYC_18940864_ChIP-ChIP_HL60_Human	1.72977050
22	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.72532414
23	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.72381655
24	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.69187729
25	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.65674426
26	AR_20517297_ChIP-Seq_VCAP_Human	1.65196571
27	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.61757406
28	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.61757406
29	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.60366619
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.57713021
31	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53370016
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.49254462
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.45299168
34	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.44857830
35	EWS_26573619_Chip-Seq_HEK293_Human	1.43513299
36	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.43438358
37	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.42542387
38	IRF1_19129219_ChIP-ChIP_H3396_Human	1.40121010
39	GATA3_26560356_Chip-Seq_TH2_Human	1.39850694
40	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.39052716
41	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.34889433
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.34077623
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.33837350
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.33837350
45	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.30016499
46	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.27547573
47	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.27354439
48	ERG_20517297_ChIP-Seq_VCAP_Human	1.27256878
49	NANOG_20526341_ChIP-Seq_ESCs_Human	1.26465398
50	TAF2_19829295_ChIP-Seq_ESCs_Human	1.25808812
51	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.25066598
52	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.23798771
53	CBP_20019798_ChIP-Seq_JUKART_Human	1.23798771
54	FUS_26573619_Chip-Seq_HEK293_Human	1.23579411
55	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.22980455
56	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.22195797
57	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.22120811
58	CIITA_25753668_ChIP-Seq_RAJI_Human	1.21936991
59	P300_19829295_ChIP-Seq_ESCs_Human	1.20915760
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19861155
61	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.19135353
62	ERA_21632823_ChIP-Seq_H3396_Human	1.17562992
63	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.17532484
64	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.16388393
65	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.13570473
66	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10429486
67	MYC_19829295_ChIP-Seq_ESCs_Human	1.09450723
68	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.08403906
69	ER_23166858_ChIP-Seq_MCF-7_Human	1.07838456
70	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.07435706
71	NCOR_22424771_ChIP-Seq_293T_Human	1.07307877
72	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.05783580
73	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.05470902
74	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04096376
75	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.04047442
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03945122
77	STAT1_20625510_ChIP-Seq_HELA_Human	1.02631024
78	GBX2_23144817_ChIP-Seq_PC3_Human	1.01967055
79	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01606807
80	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.00952031
81	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.99982184
82	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.98648651
83	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.97184653
84	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95899945
85	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93902517
86	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.93563946
87	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.93548570
88	TAF15_26573619_Chip-Seq_HEK293_Human	0.92581215
89	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.92222876
90	OCT4_20526341_ChIP-Seq_ESCs_Human	0.91570700
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.88006566
92	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.87986308
93	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.87871382
94	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.87706033
95	TTF2_22483619_ChIP-Seq_HELA_Human	0.87514564
96	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86376671
97	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.86316478
98	ELK1_22589737_ChIP-Seq_MCF10A_Human	0.85397581
99	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.84587274
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.84323675

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	5.78604051
2	MP0002138_abnormal_hepatobiliary_system	3.49154220
3	MP0008877_abnormal_DNA_methylation	3.11078641
4	MP0008789_abnormal_olfactory_epithelium	2.86057261
5	MP0001835_abnormal_antigen_presentation	2.68718380
6	MP0009379_abnormal_foot_pigmentation	2.55970212
7	MP0002638_abnormal_pupillary_reflex	2.55298701
8	MP0002102_abnormal_ear_morphology	2.49179504
9	MP0008875_abnormal_xenobiotic_pharmacok	2.46953586
10	MP0003646_muscle_fatigue	2.32333407
11	MP0003787_abnormal_imprinting	2.13901952
12	MP0005671_abnormal_response_to	2.06500144
13	MP0008872_abnormal_physiological_respon	2.04790976
14	MP0006072_abnormal_retinal_apoptosis	2.01525296
15	MP0005499_abnormal_olfactory_system	1.99541697
16	MP0005394_taste/olfaction_phenotype	1.99541697
17	MP0005257_abnormal_intraocular_pressure	1.86122536
18	MP0004147_increased_porphyrin_level	1.80847777
19	MP0005084_abnormal_gallbladder_morpholo	1.80502823
20	MP0005645_abnormal_hypothalamus_physiol	1.76698009
21	MP0001968_abnormal_touch/_nociception	1.76491780
22	MP0001986_abnormal_taste_sensitivity	1.74519630
23	MP0002938_white_spotting	1.68795004
24	MP0003011_delayed_dark_adaptation	1.65651884
25	MP0005167_abnormal_blood-brain_barrier	1.65136875
26	MP0003724_increased_susceptibility_to	1.58686823
27	MP0002876_abnormal_thyroid_physiology	1.56276373
28	MP0002837_dystrophic_cardiac_calcinosis	1.55836369
29	MP0005646_abnormal_pituitary_gland	1.52129018
30	MP0000613_abnormal_salivary_gland	1.48289530
31	MP0005551_abnormal_eye_electrophysiolog	1.47232304
32	MP0001873_stomach_inflammation	1.44792563
33	MP0009764_decreased_sensitivity_to	1.44253463
34	MP0001800_abnormal_humoral_immune	1.34998442
35	MP0008775_abnormal_heart_ventricle	1.34698021
36	MP0005389_reproductive_system_phenotype	1.30032961
37	MP0003806_abnormal_nucleotide_metabolis	1.26618884
38	MP0001919_abnormal_reproductive_system	1.25640074
39	MP0004885_abnormal_endolymph	1.23734760
40	MP0002148_abnormal_hypersensitivity_rea	1.22696381
41	MP0000685_abnormal_immune_system	1.19251077
42	MP0010155_abnormal_intestine_physiology	1.17424526
43	MP0005085_abnormal_gallbladder_physiolo	1.16252312
44	MP0003252_abnormal_bile_duct	1.16063258
45	MP0005000_abnormal_immune_tolerance	1.15957388
46	MP0000372_irregular_coat_pigmentation	1.15483075
47	MP0002160_abnormal_reproductive_system	1.14633111
48	MP0001293_anophthalmia	1.14320005
49	MP0001905_abnormal_dopamine_level	1.13543426
50	MP0002736_abnormal_nociception_after	1.12731679
51	MP0004142_abnormal_muscle_tone	1.09135862
52	MP0003866_abnormal_defecation	1.07918014
53	MP0005670_abnormal_white_adipose	1.05468523
54	MP0006036_abnormal_mitochondrial_physio	1.04426924
55	MP0002272_abnormal_nervous_system	1.03787910
56	MP0002723_abnormal_immune_serum	1.03109477
57	MP0006276_abnormal_autonomic_nervous	1.02336673
58	MP0006054_spinal_hemorrhage	1.02181130
59	MP0005253_abnormal_eye_physiology	1.02173740
60	MP0005410_abnormal_fertilization	1.01766863
61	MP0002733_abnormal_thermal_nociception	1.01766647
62	MP0005075_abnormal_melanosome_morpholog	1.00736894
63	MP0002006_tumorigenesis	1.00486657
64	MP0001485_abnormal_pinna_reflex	0.98960687
65	MP0009333_abnormal_splenocyte_physiolog	0.97948395
66	MP0001970_abnormal_pain_threshold	0.94909322
67	MP0001790_abnormal_immune_system	0.94151365
68	MP0005387_immune_system_phenotype	0.94151365
69	MP0002234_abnormal_pharynx_morphology	0.94056106
70	MP0003718_maternal_effect	0.93227349
71	MP0002166_altered_tumor_susceptibility	0.90608090
72	MP0001501_abnormal_sleep_pattern	0.90209542
73	MP0002452_abnormal_antigen_presenting	0.90160886
74	MP0001440_abnormal_grooming_behavior	0.90112746
75	MP0004145_abnormal_muscle_electrophysio	0.88233886
76	MP0008058_abnormal_DNA_repair	0.88173894
77	MP0001663_abnormal_digestive_system	0.87958178
78	MP0000230_abnormal_systemic_arterial	0.87268015
79	MP0004043_abnormal_pH_regulation	0.87184625
80	MP0009785_altered_susceptibility_to	0.87158562
81	MP0009745_abnormal_behavioral_response	0.85861114
82	MP0001845_abnormal_inflammatory_respons	0.81920341
83	MP0002420_abnormal_adaptive_immunity	0.80977818
84	MP0001819_abnormal_immune_cell	0.80901751
85	MP0003880_abnormal_central_pattern	0.80796199
86	MP0003186_abnormal_redox_activity	0.80119037
87	MP0005360_urolithiasis	0.79837405
88	MP0001765_abnormal_ion_homeostasis	0.77232318
89	MP0001486_abnormal_startle_reflex	0.77060663
90	MP0008995_early_reproductive_senescence	0.76747672
91	MP0009046_muscle_twitch	0.75911189
92	MP0003786_premature_aging	0.74027434
93	MP0003638_abnormal_response/metabolism_	0.72423176
94	MP0002277_abnormal_respiratory_mucosa	0.72300447
95	MP0005636_abnormal_mineral_homeostasis	0.71385118
96	MP0002735_abnormal_chemical_nociception	0.70818862
97	MP0000631_abnormal_neuroendocrine_gland	0.69773535
98	MP0003878_abnormal_ear_physiology	0.69340116
99	MP0005377_hearing/vestibular/ear_phenot	0.69340116
100	MP0005448_abnormal_energy_balance	0.67220932

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	3.87850727
2	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.78146682
3	Aplasia/Hypoplasia of the fovea (HP:0008060)	3.62971443
4	Hypoplasia of the fovea (HP:0007750)	3.62971443
5	Mitochondrial inheritance (HP:0001427)	3.49146277
6	Abnormal mitochondria in muscle tissue (HP:0008316)	3.39276506
7	Progressive macrocephaly (HP:0004481)	3.36058125
8	Pancreatic cysts (HP:0001737)	3.35716081
9	Hepatocellular necrosis (HP:0001404)	3.35701443
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.28742789
11	Increased CSF lactate (HP:0002490)	3.24499946
12	Acute encephalopathy (HP:0006846)	3.23626003
13	Hepatic necrosis (HP:0002605)	3.20496861
14	Pancreatic fibrosis (HP:0100732)	3.15494115
15	3-Methylglutaconic aciduria (HP:0003535)	3.09201678
16	Congenital, generalized hypertrichosis (HP:0004540)	3.05084941
17	Decreased central vision (HP:0007663)	3.04646443
18	IgG deficiency (HP:0004315)	2.92631505
19	Congenital stationary night blindness (HP:0007642)	2.90584657
20	Abnormality of the fovea (HP:0000493)	2.79625555
21	Molar tooth sign on MRI (HP:0002419)	2.79351154
22	Abnormality of midbrain morphology (HP:0002418)	2.79351154
23	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.79036422
24	Abolished electroretinogram (ERG) (HP:0000550)	2.77705947
25	Elevated erythrocyte sedimentation rate (HP:0003565)	2.76158058
26	Type 2 muscle fiber atrophy (HP:0003554)	2.73337686
27	Nephronophthisis (HP:0000090)	2.71441196
28	Abnormality of B cell number (HP:0010975)	2.71109822
29	Cerebral edema (HP:0002181)	2.68820447
30	Stomatitis (HP:0010280)	2.60740640
31	Increased hepatocellular lipid droplets (HP:0006565)	2.58865955
32	True hermaphroditism (HP:0010459)	2.57957242
33	Reticulocytopenia (HP:0001896)	2.57767247
34	Attenuation of retinal blood vessels (HP:0007843)	2.54198220
35	Abnormality of the renal cortex (HP:0011035)	2.50799463
36	Lipid accumulation in hepatocytes (HP:0006561)	2.49061987
37	Increased serum lactate (HP:0002151)	2.45875338
38	Bile duct proliferation (HP:0001408)	2.45864430
39	Abnormal biliary tract physiology (HP:0012439)	2.45864430
40	Polydipsia (HP:0001959)	2.43416930
41	Abnormal drinking behavior (HP:0030082)	2.43416930
42	B lymphocytopenia (HP:0010976)	2.42444409
43	Hypoproteinemia (HP:0003075)	2.40982076
44	Abnormality of the renal medulla (HP:0100957)	2.40968442
45	Optic disc pallor (HP:0000543)	2.35846199
46	Panhypogammaglobulinemia (HP:0003139)	2.32618710
47	Abnormality of cells of the erythroid lineage (HP:0012130)	2.30974129
48	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.29540991
49	Abnormality of the prostate (HP:0008775)	2.25139314
50	Muscle fiber atrophy (HP:0100295)	2.22549935
51	Methylmalonic acidemia (HP:0002912)	2.21379996
52	Increased corneal curvature (HP:0100692)	2.19874213
53	Keratoconus (HP:0000563)	2.19874213
54	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.19554645
55	Asplenia (HP:0001746)	2.19407609
56	Optic nerve hypoplasia (HP:0000609)	2.18357296
57	Pendular nystagmus (HP:0012043)	2.17740971
58	Aplasia/Hypoplasia of the macula (HP:0008059)	2.14013129
59	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.13596336
60	Reduced antithrombin III activity (HP:0001976)	2.12137507
61	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.12119130
62	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.11441399
63	Abnormality of alanine metabolism (HP:0010916)	2.11441399
64	Hyperalaninemia (HP:0003348)	2.11441399
65	Lactic acidosis (HP:0003128)	2.10879703
66	Severe combined immunodeficiency (HP:0004430)	2.10845093
67	Thyroiditis (HP:0100646)	2.09080027
68	Methylmalonic aciduria (HP:0012120)	2.09000828
69	Hypomagnesemia (HP:0002917)	2.03574943
70	Medial flaring of the eyebrow (HP:0010747)	2.03246456
71	Aplasia/Hypoplasia affecting the retina (HP:0008061)	2.02964461
72	Abnormal number of erythroid precursors (HP:0012131)	2.01713319
73	Renal cortical cysts (HP:0000803)	2.01571193
74	Tubular atrophy (HP:0000092)	2.00592318
75	Type I transferrin isoform profile (HP:0003642)	1.99981835
76	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.99796746
77	Lethargy (HP:0001254)	1.99391757
78	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.98976196
79	Absent/shortened dynein arms (HP:0200106)	1.98579362
80	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.98579362
81	Macrocytic anemia (HP:0001972)	1.97683046
82	Type II lissencephaly (HP:0007260)	1.96750055
83	Abnormal respiratory motile cilium morphology (HP:0005938)	1.95191600
84	Abnormal respiratory epithelium morphology (HP:0012253)	1.95191600
85	Cystic liver disease (HP:0006706)	1.92419468
86	Optic nerve coloboma (HP:0000588)	1.91533714
87	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.89779022
88	Polyuria (HP:0000103)	1.85266414
89	Hypoplasia of the ulna (HP:0003022)	1.84795534
90	Congenital hepatic fibrosis (HP:0002612)	1.84489151
91	Sclerocornea (HP:0000647)	1.84099006
92	Abnormality of T cell physiology (HP:0011840)	1.82437584
93	Abnormality of magnesium homeostasis (HP:0004921)	1.82319518
94	Increased IgM level (HP:0003496)	1.82227491
95	Increased intramyocellular lipid droplets (HP:0012240)	1.81843551
96	Renal Fanconi syndrome (HP:0001994)	1.81794930
97	Pancytopenia (HP:0001876)	1.77103017
98	Ketosis (HP:0001946)	1.76220407
99	Fibular aplasia (HP:0002990)	1.72198003
100	Aplastic anemia (HP:0001915)	1.72106352

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TIE1	3.78814958
2	BCKDK	3.65050192
3	FRK	3.05354526
4	NUAK1	3.02019779
5	GRK1	2.85555270
6	TLK1	2.81549343
7	TAOK3	2.73406090
8	CDK19	2.69146054
9	ADRBK2	2.56439603
10	ZAK	2.53002546
11	MAP4K2	2.42486505
12	WNK4	2.37818876
13	TXK	2.20543992
14	FES	2.08098353
15	BMPR1B	1.94756233
16	VRK2	1.88836467
17	PINK1	1.82494077
18	KIT	1.75697857
19	OXSR1	1.73934953
20	TEC	1.70521391
21	EIF2AK3	1.67921857
22	STK39	1.58646385
23	MAP4K1	1.58060628
24	MAP3K12	1.55472815
25	MAPK13	1.53077164
26	PIK3CA	1.46655996
27	MST4	1.43130209
28	GRK6	1.31109356
29	INSRR	1.28851765
30	ITK	1.26672430
31	MAPKAPK3	1.13010033
32	DYRK2	1.12817699
33	PTK2B	1.06561580
34	PHKG1	1.05413460
35	PHKG2	1.05413460
36	CSNK1G3	0.97537622
37	CAMKK2	0.97051163
38	SYK	0.95528435
39	RPS6KA5	0.94753123
40	IKBKB	0.93689469
41	CSNK1A1L	0.90286983
42	LRRK2	0.87243999
43	BTK	0.86420608
44	VRK1	0.85670240
45	CDK8	0.83910151
46	LYN	0.81649863
47	PLK2	0.81321201
48	EIF2AK1	0.79297366
49	TGFBR1	0.77472261
50	CSNK1G1	0.76001224
51	CSNK1G2	0.75390163
52	PRKCQ	0.71826620
53	KDR	0.69197463
54	HIPK2	0.68931353
55	CSF1R	0.66426915
56	MYLK	0.66112286
57	WNK3	0.65153768
58	ADRBK1	0.64561730
59	TRIM28	0.64123621
60	DAPK1	0.63793779
61	SCYL2	0.63162893
62	PIK3CG	0.60444231
63	FLT3	0.59648873
64	STK16	0.59400825
65	LCK	0.59048817
66	SRPK1	0.57505607
67	JAK3	0.56598391
68	MAPKAPK5	0.52607708
69	PDK2	0.52312722
70	BMPR2	0.49508898
71	DAPK2	0.49170544
72	WNK1	0.48660747
73	NME1	0.46391814
74	CAMK1	0.45805067
75	MAP2K6	0.44158511
76	PLK4	0.42752713
77	PRKCG	0.42602415
78	DAPK3	0.41697034
79	GRK5	0.41287789
80	IKBKE	0.41265549
81	PRKACA	0.39059256
82	OBSCN	0.38634108
83	PRKCE	0.38568483
84	CSNK1A1	0.37588776
85	RPS6KA4	0.37256505
86	RPS6KB2	0.37186427
87	PRKCA	0.37003869
88	PASK	0.36906876
89	MAP2K2	0.36520440
90	PIM1	0.36467546
91	IGF1R	0.35834260
92	CAMKK1	0.34743538
93	RPS6KA6	0.34136919
94	MAP3K14	0.33564192
95	PLK3	0.32022707
96	PAK3	0.31064142
97	CSNK2A2	0.30051904
98	CSNK2A1	0.28010691
99	EIF2AK2	0.27826096
100	ATR	0.26840809

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	4.81291509
2	Allograft rejection_Homo sapiens_hsa05330	3.90789645
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.70374234
4	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.60764648
5	Graft-versus-host disease_Homo sapiens_hsa05332	3.37070152
6	Ribosome_Homo sapiens_hsa03010	3.11082541
7	Type I diabetes mellitus_Homo sapiens_hsa04940	2.97827468
8	Oxidative phosphorylation_Homo sapiens_hsa00190	2.68216657
9	Proteasome_Homo sapiens_hsa03050	2.55956407
10	Parkinsons disease_Homo sapiens_hsa05012	2.07758632
11	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	1.95851158
12	Caffeine metabolism_Homo sapiens_hsa00232	1.86402092
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.85963212
14	Linoleic acid metabolism_Homo sapiens_hsa00591	1.81224552
15	Antigen processing and presentation_Homo sapiens_hsa04612	1.75760008
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.73366614
17	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.66591125
18	Rheumatoid arthritis_Homo sapiens_hsa05323	1.64331020
19	RNA polymerase_Homo sapiens_hsa03020	1.63963437
20	Primary immunodeficiency_Homo sapiens_hsa05340	1.58469855
21	Viral myocarditis_Homo sapiens_hsa05416	1.52015329
22	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.40312276
23	Alzheimers disease_Homo sapiens_hsa05010	1.38037776
24	Protein export_Homo sapiens_hsa03060	1.34821860
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.25799701
26	Huntingtons disease_Homo sapiens_hsa05016	1.22769838
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22354893
28	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.22074709
29	Nitrogen metabolism_Homo sapiens_hsa00910	1.21556825
30	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.20042463
31	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.14215390
32	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.11421790
33	One carbon pool by folate_Homo sapiens_hsa00670	1.11156274
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.07255986
35	RNA degradation_Homo sapiens_hsa03018	1.07115253
36	Homologous recombination_Homo sapiens_hsa03440	1.06148093
37	Fat digestion and absorption_Homo sapiens_hsa04975	1.05328942
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.03615728
39	Phototransduction_Homo sapiens_hsa04744	1.02088693
40	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.00567799
41	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.96312525
42	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.96263849
43	Tryptophan metabolism_Homo sapiens_hsa00380	0.96070889
44	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93066087
45	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.93033285
46	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.92627683
47	Fanconi anemia pathway_Homo sapiens_hsa03460	0.86999711
48	Leishmaniasis_Homo sapiens_hsa05140	0.85987360
49	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.85913896
50	Peroxisome_Homo sapiens_hsa04146	0.82665657
51	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.80393558
52	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80064262
53	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.78677198
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.78210355
55	Butanoate metabolism_Homo sapiens_hsa00650	0.76518355
56	Sulfur metabolism_Homo sapiens_hsa00920	0.74823061
57	Purine metabolism_Homo sapiens_hsa00230	0.73963825
58	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72764209
59	Olfactory transduction_Homo sapiens_hsa04740	0.72159625
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.71716950
61	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.71337591
62	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.68552655
63	Propanoate metabolism_Homo sapiens_hsa00640	0.68305089
64	Retinol metabolism_Homo sapiens_hsa00830	0.65807978
65	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.61332617
66	Basal transcription factors_Homo sapiens_hsa03022	0.60854793
67	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.57588918
68	Collecting duct acid secretion_Homo sapiens_hsa04966	0.55283019
69	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53233696
70	Mismatch repair_Homo sapiens_hsa03430	0.50951404
71	Metabolic pathways_Homo sapiens_hsa01100	0.49739783
72	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.49314413
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.49298135
74	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47977844
75	RNA transport_Homo sapiens_hsa03013	0.45914170
76	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.43200656
77	Glycerolipid metabolism_Homo sapiens_hsa00561	0.41894053
78	Regulation of autophagy_Homo sapiens_hsa04140	0.40609390
79	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.40568222
80	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38649512
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.38280279
82	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.37690634
83	Herpes simplex infection_Homo sapiens_hsa05168	0.36964982
84	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35955775
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.33013889
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.30360466
87	Mineral absorption_Homo sapiens_hsa04978	0.29412513
88	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.27888076
89	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.27533360
90	Salivary secretion_Homo sapiens_hsa04970	0.25812221
91	Glutathione metabolism_Homo sapiens_hsa00480	0.23674077
92	Taste transduction_Homo sapiens_hsa04742	0.21083125
93	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.20734700
94	Serotonergic synapse_Homo sapiens_hsa04726	0.18924381
95	Spliceosome_Homo sapiens_hsa03040	0.18326823
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.17941441
97	Morphine addiction_Homo sapiens_hsa05032	0.17851877
98	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.17729288
99	Nicotine addiction_Homo sapiens_hsa05033	0.17618948
100	Fatty acid degradation_Homo sapiens_hsa00071	0.17491664

RPL7P38

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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