RPL7P39

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.65163383
2negative regulation of mast cell activation (GO:0033004)5.45639813
3protein K63-linked deubiquitination (GO:0070536)5.00227423
4interferon-gamma production (GO:0032609)4.67499225
5regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.65843778
6maturation of SSU-rRNA (GO:0030490)4.62099343
7negative regulation of heart rate (GO:0010459)4.29722636
8mitochondrial calcium ion transport (GO:0006851)4.27006046
9rRNA catabolic process (GO:0016075)4.19514040
10cellular ketone body metabolic process (GO:0046950)4.11301416
11protein-cofactor linkage (GO:0018065)4.04749463
12positive regulation of interleukin-17 production (GO:0032740)3.82208233
13inositol phosphate dephosphorylation (GO:0046855)3.80851456
14phosphorylated carbohydrate dephosphorylation (GO:0046838)3.80851456
15inositol phosphate catabolic process (GO:0071545)3.79181461
16mast cell activation (GO:0045576)3.75046504
17GTP biosynthetic process (GO:0006183)3.74318547
18regulation of isotype switching to IgG isotypes (GO:0048302)3.69496533
19peptidyl-histidine modification (GO:0018202)3.68374006
20ketone body metabolic process (GO:1902224)3.66921590
21cellular response to ATP (GO:0071318)3.66297351
22UDP-N-acetylglucosamine metabolic process (GO:0006047)3.53727618
23sequestering of metal ion (GO:0051238)3.34318905
24DNA double-strand break processing (GO:0000729)3.33197981
25negative regulation of B cell apoptotic process (GO:0002903)3.32202137
26regulation of immunoglobulin secretion (GO:0051023)3.25954747
27positive regulation of B cell differentiation (GO:0045579)3.22929263
28negative regulation of heart contraction (GO:0045822)3.22871404
29mannosylation (GO:0097502)3.21851000
30regulation of regulatory T cell differentiation (GO:0045589)3.20627125
31heme transport (GO:0015886)3.20289095
32negative regulation of neurological system process (GO:0031645)3.16624867
33positive regulation of isotype switching (GO:0045830)3.16606055
34regulation of action potential (GO:0098900)3.13273034
35glomerular visceral epithelial cell development (GO:0072015)3.11340424
36negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.10975249
37positive regulation of DNA recombination (GO:0045911)3.09437286
38regulation of cilium movement (GO:0003352)3.05218367
39behavioral response to nicotine (GO:0035095)3.05005216
40positive regulation of alpha-beta T cell proliferation (GO:0046641)3.04188912
41alanine transport (GO:0032328)3.02947656
42UTP biosynthetic process (GO:0006228)3.00223835
43tongue development (GO:0043586)2.98797491
44positive regulation of vesicle fusion (GO:0031340)2.97600858
45maturation of 5.8S rRNA (GO:0000460)2.96725987
46mast cell activation involved in immune response (GO:0002279)2.95878773
47mast cell degranulation (GO:0043303)2.95878773
48regulation of B cell apoptotic process (GO:0002902)2.94190359
49protein K48-linked deubiquitination (GO:0071108)2.91348671
50protein deneddylation (GO:0000338)2.91219202
51positive regulation of interferon-gamma production (GO:0032729)2.89631842
52glomerular epithelial cell development (GO:0072310)2.89179701
53DNA deamination (GO:0045006)2.89153159
54positive regulation of granulocyte differentiation (GO:0030854)2.87739116
55ncRNA catabolic process (GO:0034661)2.87413102
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.86902851
57T cell receptor signaling pathway (GO:0050852)2.80808947
58neuron fate determination (GO:0048664)2.80487998
59regulation of cellular amino acid metabolic process (GO:0006521)2.80008798
60positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.79617521
61actin nucleation (GO:0045010)2.79538399
62cullin deneddylation (GO:0010388)2.78769468
63mature B cell differentiation (GO:0002335)2.78632511
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.78247659
65transcription elongation from RNA polymerase I promoter (GO:0006362)2.72377303
66cellular response to interleukin-15 (GO:0071350)2.71392004
67alpha-beta T cell differentiation (GO:0046632)2.70944988
68UTP metabolic process (GO:0046051)2.69720180
69reflex (GO:0060004)2.68114993
70regulation of receptor binding (GO:1900120)2.67465161
71purine-containing compound salvage (GO:0043101)2.66249242
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.65748925
73regulation of B cell receptor signaling pathway (GO:0050855)2.65716380
74ATP synthesis coupled proton transport (GO:0015986)2.64856523
75energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64856523
76response to ATP (GO:0033198)2.64799099
77positive regulation of B cell proliferation (GO:0030890)2.61546773
78S-adenosylmethionine metabolic process (GO:0046500)2.60860777
79protein localization to cilium (GO:0061512)2.59285295
80DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.57844301
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.57476276
82prenylation (GO:0097354)2.57282931
83protein prenylation (GO:0018342)2.57282931
84negative regulation of lymphocyte apoptotic process (GO:0070229)2.55672774
85regulation of acute inflammatory response to antigenic stimulus (GO:0002864)2.54828460
86Arp2/3 complex-mediated actin nucleation (GO:0034314)2.54074291
87antigen receptor-mediated signaling pathway (GO:0050851)2.53112675
88DNA excision (GO:0044349)2.53038346
89nucleotide-excision repair, DNA damage removal (GO:0000718)2.53038346
90chaperone-mediated protein transport (GO:0072321)2.52807619
91motile cilium assembly (GO:0044458)2.52452409
92termination of RNA polymerase I transcription (GO:0006363)2.52346779
93transepithelial transport (GO:0070633)2.51719046
94glyoxylate metabolic process (GO:0046487)2.51483344
95positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50942484
96positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.50202727
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.49704438
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.49704438
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.49704438
100intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.49371975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse7.04495728
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.84452455
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.14538316
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.92289705
5GABP_17652178_ChIP-ChIP_JURKAT_Human2.80567646
6VDR_22108803_ChIP-Seq_LS180_Human2.70780509
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.68643434
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55865723
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.48970883
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24552490
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.04576284
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.01372609
13VDR_23849224_ChIP-Seq_CD4+_Human1.97474381
14EST1_17652178_ChIP-ChIP_JURKAT_Human1.92266572
15FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.81892092
16ZNF274_21170338_ChIP-Seq_K562_Hela1.81269326
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74571178
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70123592
19EWS_26573619_Chip-Seq_HEK293_Human1.68029459
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.65550559
21IGF1R_20145208_ChIP-Seq_DFB_Human1.61119347
22TP53_22573176_ChIP-Seq_HFKS_Human1.58050716
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.57929373
24ETS1_20019798_ChIP-Seq_JURKAT_Human1.55792452
25NOTCH1_21737748_ChIP-Seq_TLL_Human1.54388852
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.52215514
27CBP_20019798_ChIP-Seq_JUKART_Human1.51017625
28IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51017625
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.48477181
30TAF15_26573619_Chip-Seq_HEK293_Human1.47788274
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.45310183
32SOX2_19829295_ChIP-Seq_ESCs_Human1.45237405
33NANOG_19829295_ChIP-Seq_ESCs_Human1.45237405
34FOXP3_21729870_ChIP-Seq_TREG_Human1.44579826
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41851438
36ELK1_19687146_ChIP-ChIP_HELA_Human1.40827293
37PCGF2_27294783_Chip-Seq_NPCs_Mouse1.39876280
38ER_23166858_ChIP-Seq_MCF-7_Human1.38417471
39FUS_26573619_Chip-Seq_HEK293_Human1.35483243
40AR_21572438_ChIP-Seq_LNCaP_Human1.31314158
41AR_20517297_ChIP-Seq_VCAP_Human1.24329474
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24109999
43PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.23797024
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22720829
45P300_19829295_ChIP-Seq_ESCs_Human1.21250599
46FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20665432
47KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18969957
48GATA3_26560356_Chip-Seq_TH2_Human1.18477724
49TAF2_19829295_ChIP-Seq_ESCs_Human1.15778456
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15385138
51MYC_18940864_ChIP-ChIP_HL60_Human1.15334112
52TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.14882984
53BCAT_22108803_ChIP-Seq_LS180_Human1.14818789
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.14457563
55FOXH1_21741376_ChIP-Seq_EPCs_Human1.14265104
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.13986883
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13986883
58NCOR_22424771_ChIP-Seq_293T_Human1.13523739
59NANOG_20526341_ChIP-Seq_ESCs_Human1.10418038
60NFE2_27457419_Chip-Seq_LIVER_Mouse1.10262642
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09206333
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08651989
63MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07970452
64YY1_21170310_ChIP-Seq_MESCs_Mouse1.07521332
65EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06927294
66MYB_26560356_Chip-Seq_TH2_Human1.06852634
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06745657
68FOXH1_21741376_ChIP-Seq_ESCs_Human1.02380455
69RUNX_20019798_ChIP-Seq_JUKART_Human1.02346347
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01604454
71ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01551774
72BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01017641
73CIITA_25753668_ChIP-Seq_RAJI_Human1.00445242
74HOXB7_26014856_ChIP-Seq_BT474_Human0.98793184
75ELK1_22589737_ChIP-Seq_MCF10A_Human0.97475572
76TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96443108
77EZH2_22144423_ChIP-Seq_EOC_Human0.95879873
78SRF_21415370_ChIP-Seq_HL-1_Mouse0.95620068
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95384211
80GATA3_27048872_Chip-Seq_THYMUS_Human0.94374433
81FOXA1_21572438_ChIP-Seq_LNCaP_Human0.94261012
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93513695
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93513695
84PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93223108
85GATA6_21074721_ChIP-Seq_CACO-2_Human0.93187038
86EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91612990
87PRDM14_20953172_ChIP-Seq_ESCs_Human0.91084499
88RBPJ_21746931_ChIP-Seq_IB4_Human0.90632390
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.90604030
90AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90539778
91EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90525965
92LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.89877794
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.89409565
94CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.87161882
95OCT4_18555785_Chip-Seq_ESCs_Mouse0.86763557
96CRX_20693478_ChIP-Seq_RETINA_Mouse0.86675558
97STAT3_18555785_Chip-Seq_ESCs_Mouse0.85526623
98CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84669737
99GATA3_26560356_Chip-Seq_TH1_Human0.84495616
100GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.83681466

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy4.65635760
2MP0005377_hearing/vestibular/ear_phenot4.34945474
3MP0003878_abnormal_ear_physiology4.34945474
4MP0003300_gastrointestinal_ulcer3.50538326
5MP0005645_abnormal_hypothalamus_physiol3.12925153
6MP0002102_abnormal_ear_morphology2.97661959
7MP0005671_abnormal_response_to2.93100885
8MP0001835_abnormal_antigen_presentation2.77418066
9MP0009785_altered_susceptibility_to2.55400984
10MP0003646_muscle_fatigue2.43445177
11MP0010386_abnormal_urinary_bladder2.27860620
12MP0003045_fibrosis2.27485651
13MP0004885_abnormal_endolymph2.12575819
14MP0002166_altered_tumor_susceptibility2.11773375
15MP0005075_abnormal_melanosome_morpholog2.10824095
16MP0001984_abnormal_olfaction2.04763252
17MP0006072_abnormal_retinal_apoptosis2.03257871
18MP0002638_abnormal_pupillary_reflex1.96084516
19MP0001853_heart_inflammation1.91236850
20MP0009333_abnormal_splenocyte_physiolog1.89448539
21MP0003693_abnormal_embryo_hatching1.86824833
22MP0002006_tumorigenesis1.81175137
23MP0008875_abnormal_xenobiotic_pharmacok1.79350836
24MP0002148_abnormal_hypersensitivity_rea1.63801031
25MP0002272_abnormal_nervous_system1.56755003
26MP0005551_abnormal_eye_electrophysiolog1.55013673
27MP0003880_abnormal_central_pattern1.48381719
28MP0003806_abnormal_nucleotide_metabolis1.45492868
29MP0005646_abnormal_pituitary_gland1.45338693
30MP0002736_abnormal_nociception_after1.45147686
31MP0001800_abnormal_humoral_immune1.44192258
32MP0001529_abnormal_vocalization1.41701719
33MP0004142_abnormal_muscle_tone1.39604069
34MP0009046_muscle_twitch1.38417622
35MP0004147_increased_porphyrin_level1.36867271
36MP0001905_abnormal_dopamine_level1.34915173
37MP0010155_abnormal_intestine_physiology1.33257720
38MP0003195_calcinosis1.29343275
39MP0005389_reproductive_system_phenotype1.26891892
40MP0003866_abnormal_defecation1.26274277
41MP0000465_gastrointestinal_hemorrhage1.23969542
42MP0002723_abnormal_immune_serum1.23880252
43MP0001440_abnormal_grooming_behavior1.21760772
44MP0002735_abnormal_chemical_nociception1.21366302
45MP0008872_abnormal_physiological_respon1.20581405
46MP0004381_abnormal_hair_follicle1.19241086
47MP0001968_abnormal_touch/_nociception1.16881742
48MP0003763_abnormal_thymus_physiology1.16209214
49MP0003718_maternal_effect1.15765724
50MP0005000_abnormal_immune_tolerance1.15233138
51MP0005332_abnormal_amino_acid1.15193302
52MP0004924_abnormal_behavior1.12666969
53MP0005386_behavior/neurological_phenoty1.12666969
54MP0005025_abnormal_response_to1.07850691
55MP0001845_abnormal_inflammatory_respons1.07724183
56MP0001919_abnormal_reproductive_system1.07468964
57MP0002452_abnormal_antigen_presenting1.07442725
58MP0002420_abnormal_adaptive_immunity1.07304145
59MP0002837_dystrophic_cardiac_calcinosis1.06341780
60MP0002693_abnormal_pancreas_physiology1.05953200
61MP0006276_abnormal_autonomic_nervous1.04958841
62MP0002160_abnormal_reproductive_system1.04792735
63MP0001819_abnormal_immune_cell1.04547865
64MP0000538_abnormal_urinary_bladder1.04438743
65MP0009764_decreased_sensitivity_to1.03555930
66MP0001970_abnormal_pain_threshold0.99867631
67MP0003724_increased_susceptibility_to0.99344384
68MP0005085_abnormal_gallbladder_physiolo0.97002387
69MP0005408_hypopigmentation0.95682879
70MP0001485_abnormal_pinna_reflex0.95424561
71MP0001873_stomach_inflammation0.94809328
72MP0005253_abnormal_eye_physiology0.94609290
73MP0008057_abnormal_DNA_replication0.90090345
74MP0001963_abnormal_hearing_physiology0.89961030
75MP0005636_abnormal_mineral_homeostasis0.89120979
76MP0000685_abnormal_immune_system0.88867256
77MP0003890_abnormal_embryonic-extraembry0.87700287
78MP0005410_abnormal_fertilization0.86598785
79MP0001764_abnormal_homeostasis0.86586126
80MP0000026_abnormal_inner_ear0.84589667
81MP0002405_respiratory_system_inflammati0.84004875
82MP0005167_abnormal_blood-brain_barrier0.81750714
83MP0006036_abnormal_mitochondrial_physio0.81663402
84MP0000470_abnormal_stomach_morphology0.78968364
85MP0008877_abnormal_DNA_methylation0.78373986
86MP0002398_abnormal_bone_marrow0.75964068
87MP0001501_abnormal_sleep_pattern0.75659641
88MP0001486_abnormal_startle_reflex0.75103295
89MP0008469_abnormal_protein_level0.74004765
90MP0001986_abnormal_taste_sensitivity0.70601013
91MP0001664_abnormal_digestion0.69838018
92MP0005670_abnormal_white_adipose0.69678937
93MP0002419_abnormal_innate_immunity0.69632952
94MP0000516_abnormal_urinary_system0.69594816
95MP0005367_renal/urinary_system_phenotyp0.69594816
96MP0009745_abnormal_behavioral_response0.69202172
97MP0004215_abnormal_myocardial_fiber0.68621512
98MP0005084_abnormal_gallbladder_morpholo0.68496231
99MP0005387_immune_system_phenotype0.67804822
100MP0001790_abnormal_immune_system0.67804822

Predicted human phenotypes

RankGene SetZ-score
1Hypoproteinemia (HP:0003075)6.05937614
2Aplastic anemia (HP:0001915)5.53413477
3Reduced antithrombin III activity (HP:0001976)5.21339898
4Type I transferrin isoform profile (HP:0003642)4.66195079
5Hypochromic microcytic anemia (HP:0004840)4.43021544
6Absent/shortened dynein arms (HP:0200106)4.20173969
7Dynein arm defect of respiratory motile cilia (HP:0012255)4.20173969
8Methylmalonic acidemia (HP:0002912)4.12961737
9Abnormality of homocysteine metabolism (HP:0010919)3.85399273
10Homocystinuria (HP:0002156)3.85399273
113-Methylglutaconic aciduria (HP:0003535)3.67917496
12Stomatitis (HP:0010280)3.62431220
13Elevated erythrocyte sedimentation rate (HP:0003565)3.31032536
14Abnormal protein glycosylation (HP:0012346)3.29599378
15Abnormal glycosylation (HP:0012345)3.29599378
16Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.29599378
17Abnormal protein N-linked glycosylation (HP:0012347)3.29599378
18Methylmalonic aciduria (HP:0012120)3.21820680
19Pigmentary retinal degeneration (HP:0001146)3.16567652
20Absent thumb (HP:0009777)3.15076607
21Abnormality of the vitamin B12 metabolism (HP:0004341)3.07699201
22Abnormality of vitamin B metabolism (HP:0004340)3.05370963
23Aplasia/Hypoplasia of the uvula (HP:0010293)3.05359149
24Abnormality of DNA repair (HP:0003254)2.97903971
25Acute lymphatic leukemia (HP:0006721)2.94456077
26Abnormal respiratory epithelium morphology (HP:0012253)2.93795090
27Abnormal respiratory motile cilium morphology (HP:0005938)2.93795090
28Abnormal ciliary motility (HP:0012262)2.91101160
29Clubbing of toes (HP:0100760)2.89741318
30IgG deficiency (HP:0004315)2.89631704
31Abnormality of the ileum (HP:0001549)2.80150330
32Meckel diverticulum (HP:0002245)2.76085952
33Hypoplasia of the pons (HP:0012110)2.62048220
34Abnormality of the preputium (HP:0100587)2.61327832
35Mitochondrial inheritance (HP:0001427)2.59295209
36Abnormality of methionine metabolism (HP:0010901)2.53635577
37Acute necrotizing encephalopathy (HP:0006965)2.48548883
38Progressive macrocephaly (HP:0004481)2.40834520
39Abnormality of the pons (HP:0007361)2.39665378
40Poor head control (HP:0002421)2.39615176
41Hepatocellular necrosis (HP:0001404)2.37962458
42Pancreatic cysts (HP:0001737)2.36115708
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.34038591
44Abnormal respiratory motile cilium physiology (HP:0012261)2.33884421
45Hepatic necrosis (HP:0002605)2.30444415
46Thyroiditis (HP:0100646)2.27111107
47Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19287870
48Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19287870
49Duplicated collecting system (HP:0000081)2.16766358
50Abnormal mitochondria in muscle tissue (HP:0008316)2.16642952
51Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16504316
52Alkalosis (HP:0001948)2.15739958
53Medial flaring of the eyebrow (HP:0010747)2.15382696
54Metabolic alkalosis (HP:0200114)2.13895490
55Autoimmune thrombocytopenia (HP:0001973)2.13848897
56Large for gestational age (HP:0001520)2.12549143
57Increased CSF lactate (HP:0002490)2.11427515
58Abnormality of vitamin metabolism (HP:0100508)2.11178387
59Abnormality of the renal collecting system (HP:0004742)2.10622542
60Abnormality of chromosome stability (HP:0003220)2.05388716
61Congenital, generalized hypertrichosis (HP:0004540)2.02646547
62Hypokalemic alkalosis (HP:0001949)2.02016439
63Acute encephalopathy (HP:0006846)1.95466404
64Congenital primary aphakia (HP:0007707)1.95179370
65Exertional dyspnea (HP:0002875)1.94287600
66Recurrent sinusitis (HP:0011108)1.92574585
67Type II lissencephaly (HP:0007260)1.91890339
68Severe combined immunodeficiency (HP:0004430)1.90820513
69Gait imbalance (HP:0002141)1.88479233
70Attenuation of retinal blood vessels (HP:0007843)1.86676517
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.86321261
72Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86110010
73Dicarboxylic aciduria (HP:0003215)1.86110010
74Oligomenorrhea (HP:0000876)1.85446432
75True hermaphroditism (HP:0010459)1.84777780
76Panhypogammaglobulinemia (HP:0003139)1.84108678
77Hypochromic anemia (HP:0001931)1.82163268
78Amelogenesis imperfecta (HP:0000705)1.81505948
79Prolonged QT interval (HP:0001657)1.80901971
80Abnormality of the renal cortex (HP:0011035)1.80354783
81Polydipsia (HP:0001959)1.80237552
82Abnormal drinking behavior (HP:0030082)1.80237552
83Facial diplegia (HP:0001349)1.79229893
84Chronic hepatic failure (HP:0100626)1.78458302
85Abnormal spermatogenesis (HP:0008669)1.75531180
86Pancytopenia (HP:0001876)1.74714848
87Abnormality of the prostate (HP:0008775)1.74654184
88Congenital stationary night blindness (HP:0007642)1.74259857
89Poor coordination (HP:0002370)1.74222295
90Chronic otitis media (HP:0000389)1.73920286
91Abolished electroretinogram (ERG) (HP:0000550)1.72858951
92Decreased circulating renin level (HP:0003351)1.70974404
93Triphalangeal thumb (HP:0001199)1.70793003
94Reticulocytopenia (HP:0001896)1.68236480
95Polyuria (HP:0000103)1.67762599
96Abnormal albumin level (HP:0012116)1.67561406
97Hypoalbuminemia (HP:0003073)1.67561406
98Poor speech (HP:0002465)1.67142877
99Abnormality of eosinophils (HP:0001879)1.64267434
100Abnormality of sulfur amino acid metabolism (HP:0004339)1.63804709

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.30731977
2TAOK36.14259523
3NUAK13.82215501
4CDK193.55927908
5PASK3.33095383
6SCYL23.09451550
7MST42.80672326
8FRK2.66764194
9MAP3K122.30644426
10IKBKE2.16992597
11OXSR12.13948908
12ADRBK22.09378611
13JAK31.97913971
14TEC1.77969520
15SIK21.70867643
16NLK1.62169609
17TLK11.62110125
18ITK1.60628693
19BMPR21.59870755
20NEK11.57520640
21TSSK61.53985206
22GRK11.48797164
23EIF2AK31.37554738
24ERBB31.28271824
25KIT1.24554143
26MAP4K21.22025857
27EIF2AK11.07767907
28ZAK1.06574142
29IKBKB1.05305100
30MAP3K140.98841920
31BTK0.98115590
32MARK30.96250233
33VRK20.91536663
34CAMKK10.91029094
35BCKDK0.88695328
36SIK30.84414497
37LYN0.81895598
38EPHA30.80848310
39SYK0.79084085
40STK390.77359084
41DYRK1B0.74842726
42AKT30.73452782
43KDR0.72015519
44LCK0.71853481
45FGR0.69806262
46DYRK20.68285478
47NEK90.63812294
48STK110.60605912
49INSRR0.53988524
50WNK40.53895205
51TRPM70.52503166
52IRAK40.52394101
53TAF10.51655306
54CAMKK20.51593915
55CSF1R0.50323078
56MAP2K60.49745947
57IGF1R0.48190498
58TIE10.47256021
59FES0.46129038
60HIPK20.44961539
61WNK30.42974216
62MAPKAPK50.42752880
63ADRBK10.42690793
64CLK10.40096998
65NEK20.39290385
66NME10.39236044
67PRKCE0.38784397
68RPS6KA50.36364864
69ILK0.36100702
70CDK80.35404694
71DAPK20.34747824
72PRKCA0.34242791
73MAP4K10.32999413
74RPS6KA60.32403885
75OBSCN0.32324968
76PHKG20.31287113
77PHKG10.31287113
78FLT30.31248033
79ATR0.29406662
80DAPK30.29228281
81PRKACA0.29102332
82FGFR30.28097954
83PRKG10.27621732
84CHUK0.25900761
85MYLK0.25751684
86MAPK130.24114276
87ZAP700.23886367
88DMPK0.23594920
89MAPK150.22507106
90RPS6KL10.21454139
91RPS6KC10.21454139
92MUSK0.21417195
93STK160.21051120
94PRKAA20.20514140
95INSR0.20359018
96FYN0.20279623
97CSNK2A10.19924477
98JAK10.19800549
99PRKCQ0.18547781
100VRK10.18274579

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.38694329
2Allograft rejection_Homo sapiens_hsa053303.74872746
3Type I diabetes mellitus_Homo sapiens_hsa049403.58460205
4Graft-versus-host disease_Homo sapiens_hsa053323.57035077
5Autoimmune thyroid disease_Homo sapiens_hsa053203.55798544
6Proteasome_Homo sapiens_hsa030503.39485035
7Intestinal immune network for IgA production_Homo sapiens_hsa046723.38413359
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.54678099
9Oxidative phosphorylation_Homo sapiens_hsa001902.28446172
10Rheumatoid arthritis_Homo sapiens_hsa053232.20446274
11Primary immunodeficiency_Homo sapiens_hsa053402.15720507
12Antigen processing and presentation_Homo sapiens_hsa046122.03110715
13Ribosome_Homo sapiens_hsa030101.96488756
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.92396230
15One carbon pool by folate_Homo sapiens_hsa006701.78332057
16RNA polymerase_Homo sapiens_hsa030201.74876434
17Protein export_Homo sapiens_hsa030601.72751560
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67279855
19Phototransduction_Homo sapiens_hsa047441.59032035
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.53390322
21Staphylococcus aureus infection_Homo sapiens_hsa051501.52691702
22Parkinsons disease_Homo sapiens_hsa050121.47758908
23Hematopoietic cell lineage_Homo sapiens_hsa046401.43318470
24Collecting duct acid secretion_Homo sapiens_hsa049661.36846814
25Nitrogen metabolism_Homo sapiens_hsa009101.36691071
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36622642
27Regulation of autophagy_Homo sapiens_hsa041401.30191840
28Nicotine addiction_Homo sapiens_hsa050331.23204473
29Viral myocarditis_Homo sapiens_hsa054161.17257421
30Basal transcription factors_Homo sapiens_hsa030221.15797671
31Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13820695
32Leishmaniasis_Homo sapiens_hsa051401.12364472
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12264655
34Fatty acid biosynthesis_Homo sapiens_hsa000610.95978837
35Fanconi anemia pathway_Homo sapiens_hsa034600.95808788
36Butanoate metabolism_Homo sapiens_hsa006500.94549114
37Systemic lupus erythematosus_Homo sapiens_hsa053220.93034206
38Arginine biosynthesis_Homo sapiens_hsa002200.91094568
39Alzheimers disease_Homo sapiens_hsa050100.90824350
40ABC transporters_Homo sapiens_hsa020100.88235733
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86852934
42Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85864400
43Purine metabolism_Homo sapiens_hsa002300.84402960
44Vitamin digestion and absorption_Homo sapiens_hsa049770.83883656
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83412583
46RNA degradation_Homo sapiens_hsa030180.82562796
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82431592
48Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81847717
49Tryptophan metabolism_Homo sapiens_hsa003800.81126995
50Olfactory transduction_Homo sapiens_hsa047400.80004967
51NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77848299
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76916191
53Salivary secretion_Homo sapiens_hsa049700.76205632
54T cell receptor signaling pathway_Homo sapiens_hsa046600.76049979
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.75601195
56Huntingtons disease_Homo sapiens_hsa050160.73564343
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.72809301
58Linoleic acid metabolism_Homo sapiens_hsa005910.72585563
59Ether lipid metabolism_Homo sapiens_hsa005650.66779210
60Tuberculosis_Homo sapiens_hsa051520.63250968
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61905047
62Morphine addiction_Homo sapiens_hsa050320.61883089
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61795419
64Phagosome_Homo sapiens_hsa041450.60410901
65Nucleotide excision repair_Homo sapiens_hsa034200.59817593
66Herpes simplex infection_Homo sapiens_hsa051680.59725370
67Primary bile acid biosynthesis_Homo sapiens_hsa001200.58683215
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56885892
69Propanoate metabolism_Homo sapiens_hsa006400.56626477
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.55977699
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.55359509
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53328928
73Chemical carcinogenesis_Homo sapiens_hsa052040.52079145
74Pyrimidine metabolism_Homo sapiens_hsa002400.51209497
75Histidine metabolism_Homo sapiens_hsa003400.50811469
76Cardiac muscle contraction_Homo sapiens_hsa042600.49046162
77GABAergic synapse_Homo sapiens_hsa047270.48893840
78Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47757356
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46582224
80Vibrio cholerae infection_Homo sapiens_hsa051100.46549000
81Measles_Homo sapiens_hsa051620.46531428
82Peroxisome_Homo sapiens_hsa041460.46323347
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45121354
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44515311
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.43676068
86Toxoplasmosis_Homo sapiens_hsa051450.42812499
87Metabolic pathways_Homo sapiens_hsa011000.39750140
88Starch and sucrose metabolism_Homo sapiens_hsa005000.38455528
89Epstein-Barr virus infection_Homo sapiens_hsa051690.37861081
90Taste transduction_Homo sapiens_hsa047420.37516103
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37127888
92Influenza A_Homo sapiens_hsa051640.36562272
93Malaria_Homo sapiens_hsa051440.36350971
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33613703
95Caffeine metabolism_Homo sapiens_hsa002320.32745505
96beta-Alanine metabolism_Homo sapiens_hsa004100.32426517
97Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29126344
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27804295
99Glycerolipid metabolism_Homo sapiens_hsa005610.27537480
100Synaptic vesicle cycle_Homo sapiens_hsa047210.25161447

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