ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	energy coupled proton transport, down electrochemical gradient (GO:0015985)	5.03150136
2	ATP synthesis coupled proton transport (GO:0015986)	5.03150136
3	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	4.83493944
4	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.67013034
5	ribosomal small subunit assembly (GO:0000028)	4.21714211
6	DNA deamination (GO:0045006)	4.04260578
7	regulation of antigen processing and presentation of peptide antigen (GO:0002583)	4.01476607
8	respiratory electron transport chain (GO:0022904)	4.00852393
9	electron transport chain (GO:0022900)	3.99628864
10	negative regulation of mast cell activation (GO:0033004)	3.87404976
11	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.57137729
12	positive regulation of inflammatory response to antigenic stimulus (GO:0002863)	3.53504932
13	immunoglobulin mediated immune response (GO:0016064)	3.48982015
14	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.48134121
15	regulation of hypersensitivity (GO:0002883)	3.42141964
16	protein complex biogenesis (GO:0070271)	3.36929226
17	viral transcription (GO:0019083)	3.35143409
18	ribosomal large subunit biogenesis (GO:0042273)	3.33261389
19	indole-containing compound catabolic process (GO:0042436)	3.30515005
20	indolalkylamine catabolic process (GO:0046218)	3.30515005
21	tryptophan catabolic process (GO:0006569)	3.30515005
22	respiratory chain complex IV assembly (GO:0008535)	3.30343677
23	translational termination (GO:0006415)	3.26255136
24	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	3.19823972
25	platelet dense granule organization (GO:0060155)	3.19453061
26	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.19269233
27	cotranslational protein targeting to membrane (GO:0006613)	3.12966845
28	cytochrome complex assembly (GO:0017004)	3.07939812
29	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.05882111
30	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.05882111
31	NADH dehydrogenase complex assembly (GO:0010257)	3.05882111
32	protein targeting to ER (GO:0045047)	3.04730772
33	hydrogen ion transmembrane transport (GO:1902600)	2.99783878
34	protein localization to endoplasmic reticulum (GO:0070972)	2.99738911
35	kynurenine metabolic process (GO:0070189)	2.99646898
36	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.99487072
37	cellular ketone body metabolic process (GO:0046950)	2.98052382
38	protein neddylation (GO:0045116)	2.96791429
39	Arp2/3 complex-mediated actin nucleation (GO:0034314)	2.95250653
40	prenylation (GO:0097354)	2.95060532
41	protein prenylation (GO:0018342)	2.95060532
42	mast cell activation (GO:0045576)	2.93662774
43	proton transport (GO:0015992)	2.92796749
44	proteasome assembly (GO:0043248)	2.89720811
45	establishment of protein localization to endoplasmic reticulum (GO:0072599)	2.89619894
46	hydrogen transport (GO:0006818)	2.89324792
47	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87722717
48	regulation of B cell receptor signaling pathway (GO:0050855)	2.85966522
49	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.85588716
50	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.85588716
51	translational elongation (GO:0006414)	2.85570487
52	B cell mediated immunity (GO:0019724)	2.83256093
53	actin nucleation (GO:0045010)	2.81500481
54	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.80469583
55	tryptophan metabolic process (GO:0006568)	2.78910563
56	purine deoxyribonucleotide catabolic process (GO:0009155)	2.77764481
57	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.75998019
58	ATP biosynthetic process (GO:0006754)	2.75716671
59	negative regulation of heart rate (GO:0010459)	2.75105091
60	regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)	2.74746736
61	termination of RNA polymerase III transcription (GO:0006386)	2.74208932
62	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.74208932
63	phenol-containing compound catabolic process (GO:0019336)	2.73825600
64	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	2.72977004
65	positive regulation of mast cell degranulation (GO:0043306)	2.68485388
66	positive regulation of mast cell activation involved in immune response (GO:0033008)	2.68485388
67	ketone body metabolic process (GO:1902224)	2.67378179
68	aldehyde catabolic process (GO:0046185)	2.62426673
69	positive regulation of interleukin-1 beta secretion (GO:0050718)	2.61924107
70	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	2.60098577
71	purine nucleoside triphosphate biosynthetic process (GO:0009145)	2.59520511
72	interferon-gamma-mediated signaling pathway (GO:0060333)	2.59372252
73	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	2.57258264
74	positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)	2.56249158
75	positive regulation of alpha-beta T cell proliferation (GO:0046641)	2.56120419
76	S-adenosylmethionine metabolic process (GO:0046500)	2.56030901
77	response to interferon-beta (GO:0035456)	2.54655626
78	positive regulation of mast cell activation (GO:0033005)	2.54226975
79	thyroid hormone generation (GO:0006590)	2.54016792
80	indolalkylamine metabolic process (GO:0006586)	2.53803105
81	one-carbon compound transport (GO:0019755)	2.52937739
82	regulation of interleukin-1 beta secretion (GO:0050706)	2.51869425
83	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.51724342
84	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	2.51299043
85	T cell receptor signaling pathway (GO:0050852)	2.50083360
86	mast cell degranulation (GO:0043303)	2.46339977
87	mast cell activation involved in immune response (GO:0002279)	2.46339977
88	T cell costimulation (GO:0031295)	2.46088184
89	positive regulation of interleukin-1 secretion (GO:0050716)	2.45926900
90	translation (GO:0006412)	2.45760066
91	sequestering of actin monomers (GO:0042989)	2.45625865
92	aromatic amino acid family catabolic process (GO:0009074)	2.43797144
93	lymphocyte costimulation (GO:0031294)	2.43693492
94	adenosine metabolic process (GO:0046085)	2.43124597
95	glutathione derivative biosynthetic process (GO:1901687)	2.41890153
96	glutathione derivative metabolic process (GO:1901685)	2.41890153
97	purine deoxyribonucleotide metabolic process (GO:0009151)	2.41698498
98	regulation of alpha-beta T cell proliferation (GO:0046640)	2.41535521
99	regulation of antigen processing and presentation (GO:0002577)	2.40920296
100	GPI anchor biosynthetic process (GO:0006506)	2.40919196

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.14585014
2	BP1_19119308_ChIP-ChIP_Hs578T_Human	3.77973854
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	3.06918550
4	VDR_22108803_ChIP-Seq_LS180_Human	3.02845821
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.56513919
6	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.41567455
7	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.38745148
8	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.37678814
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34214421
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.30638017
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.21453712
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.20151027
13	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.08137451
14	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.04585525
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.01746494
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.94092687
17	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.91720694
18	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.83982490
19	EWS_26573619_Chip-Seq_HEK293_Human	1.81049029
20	ELK1_19687146_ChIP-ChIP_HELA_Human	1.80156260
21	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.80088801
22	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.78810853
23	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.78546349
24	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.75958595
25	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.74914742
26	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70533128
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.69775046
28	FUS_26573619_Chip-Seq_HEK293_Human	1.69650753
29	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.65415545
30	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.63071639
31	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.63071639
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.61322668
33	GATA3_26560356_Chip-Seq_TH2_Human	1.60565131
34	FOXP3_21729870_ChIP-Seq_TREG_Human	1.60285237
35	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.60232872
36	AR_20517297_ChIP-Seq_VCAP_Human	1.59637593
37	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.53503300
38	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.52837096
39	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.49703255
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.48744004
41	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.47148353
42	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.44580234
43	SOX2_19829295_ChIP-Seq_ESCs_Human	1.44540117
44	NANOG_19829295_ChIP-Seq_ESCs_Human	1.44540117
45	P300_19829295_ChIP-Seq_ESCs_Human	1.43938275
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.42814745
47	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.42814745
48	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.42261416
49	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.41392348
50	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.39640944
51	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.38224292
52	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.37395394
53	ER_23166858_ChIP-Seq_MCF-7_Human	1.35487052
54	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32713963
55	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.31576179
56	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.30964253
57	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28282742
58	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.28255341
59	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.27272154
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24957662
61	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.24722609
62	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.22638200
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.21647011
64	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.20758704
65	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.20530443
66	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.19353801
67	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.17348298
68	GBX2_23144817_ChIP-Seq_PC3_Human	1.16373865
69	MYB_26560356_Chip-Seq_TH2_Human	1.13281694
70	TAF2_19829295_ChIP-Seq_ESCs_Human	1.12451230
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.11922770
72	MYC_18940864_ChIP-ChIP_HL60_Human	1.10850962
73	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.09816399
74	ERG_20517297_ChIP-Seq_VCAP_Human	1.09535604
75	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.07799255
76	NCOR_22424771_ChIP-Seq_293T_Human	1.07451360
77	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.07213242
78	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06718740
79	IRF1_19129219_ChIP-ChIP_H3396_Human	1.05702899
80	SPI1_23547873_ChIP-Seq_NB4_Human	1.04295086
81	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.02500203
82	GATA3_27048872_Chip-Seq_THYMUS_Human	1.01340825
83	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01003155
84	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.00841320
85	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	0.99959412
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.99955645
87	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.99642520
88	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97637992
89	MYC_18555785_ChIP-Seq_MESCs_Mouse	0.97127647
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.97114230
91	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	0.96925297
92	MYC_19829295_ChIP-Seq_ESCs_Human	0.96654803
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.96427611
94	P53_22387025_ChIP-Seq_ESCs_Mouse	0.93830284
95	GATA3_26560356_Chip-Seq_TH1_Human	0.93596485
96	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93421284
97	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.93199037
98	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.93091431
99	TDRD3_21172665_ChIP-Seq_MCF-7_Human	0.92995620
100	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	0.91905357

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001835_abnormal_antigen_presentation	4.28288501
2	MP0009379_abnormal_foot_pigmentation	3.41327834
3	MP0003806_abnormal_nucleotide_metabolis	3.07358999
4	MP0005671_abnormal_response_to	3.04947977
5	MP0006072_abnormal_retinal_apoptosis	2.86399391
6	MP0005075_abnormal_melanosome_morpholog	2.56644041
7	MP0008875_abnormal_xenobiotic_pharmacok	2.40024138
8	MP0002166_altered_tumor_susceptibility	2.32858489
9	MP0002837_dystrophic_cardiac_calcinosis	2.24875100
10	MP0001968_abnormal_touch/_nociception	2.08380005
11	MP0009785_altered_susceptibility_to	2.03020750
12	MP0005551_abnormal_eye_electrophysiolog	2.00551643
13	MP0002006_tumorigenesis	1.89974176
14	MP0005646_abnormal_pituitary_gland	1.84706230
15	MP0001800_abnormal_humoral_immune	1.83828134
16	MP0009764_decreased_sensitivity_to	1.77470168
17	MP0001986_abnormal_taste_sensitivity	1.75890138
18	MP0008872_abnormal_physiological_respon	1.72091886
19	MP0002148_abnormal_hypersensitivity_rea	1.71237799
20	MP0000685_abnormal_immune_system	1.67693347
21	MP0005000_abnormal_immune_tolerance	1.67531982
22	MP0000516_abnormal_urinary_system	1.67158764
23	MP0005367_renal/urinary_system_phenotyp	1.67158764
24	MP0005253_abnormal_eye_physiology	1.62554268
25	MP0002736_abnormal_nociception_after	1.60924416
26	MP0004142_abnormal_muscle_tone	1.56931544
27	MP0000372_irregular_coat_pigmentation	1.55434642
28	MP0002138_abnormal_hepatobiliary_system	1.46639215
29	MP0002163_abnormal_gland_morphology	1.46128328
30	MP0002723_abnormal_immune_serum	1.45764660
31	MP0002452_abnormal_antigen_presenting	1.45433881
32	MP0008995_early_reproductive_senescence	1.43685565
33	MP0005387_immune_system_phenotype	1.38817203
34	MP0001790_abnormal_immune_system	1.38817203
35	MP0005645_abnormal_hypothalamus_physiol	1.35806297
36	MP0003195_calcinosis	1.35691472
37	MP0002102_abnormal_ear_morphology	1.34868959
38	MP0004145_abnormal_muscle_electrophysio	1.34359775
39	MP0006292_abnormal_olfactory_placode	1.34253064
40	MP0008877_abnormal_DNA_methylation	1.33966158
41	MP0003866_abnormal_defecation	1.30338575
42	MP0003724_increased_susceptibility_to	1.29490389
43	MP0001819_abnormal_immune_cell	1.26900608
44	MP0002234_abnormal_pharynx_morphology	1.26367819
45	MP0006036_abnormal_mitochondrial_physio	1.26312598
46	MP0000569_abnormal_digit_pigmentation	1.26027818
47	MP0003646_muscle_fatigue	1.24582302
48	MP0002420_abnormal_adaptive_immunity	1.22828317
49	MP0005408_hypopigmentation	1.20818274
50	MP0001529_abnormal_vocalization	1.17464285
51	MP0001905_abnormal_dopamine_level	1.17176031
52	MP0001501_abnormal_sleep_pattern	1.15555411
53	MP0006276_abnormal_autonomic_nervous	1.14967270
54	MP0009333_abnormal_splenocyte_physiolog	1.13772754
55	MP0000427_abnormal_hair_cycle	1.13535454
56	MP0010155_abnormal_intestine_physiology	1.12371757
57	MP0001764_abnormal_homeostasis	1.11548375
58	MP0002638_abnormal_pupillary_reflex	1.10932108
59	MP0009697_abnormal_copulation	1.09259507
60	MP0005377_hearing/vestibular/ear_phenot	1.08400403
61	MP0003878_abnormal_ear_physiology	1.08400403
62	MP0002095_abnormal_skin_pigmentation	1.07295118
63	MP0005025_abnormal_response_to	1.05943414
64	MP0003786_premature_aging	1.04967562
65	MP0003880_abnormal_central_pattern	1.04743767
66	MP0005174_abnormal_tail_pigmentation	1.02312723
67	MP0004885_abnormal_endolymph	1.01175012
68	MP0004147_increased_porphyrin_level	1.01033492
69	MP0005389_reproductive_system_phenotype	1.00348317
70	MP0003122_maternal_imprinting	0.96644083
71	MP0001845_abnormal_inflammatory_respons	0.96453257
72	MP0001919_abnormal_reproductive_system	0.96207811
73	MP0005379_endocrine/exocrine_gland_phen	0.94383282
74	MP0002735_abnormal_chemical_nociception	0.94320566
75	MP0009046_muscle_twitch	0.94080811
76	MP0001970_abnormal_pain_threshold	0.93194708
77	MP0003252_abnormal_bile_duct	0.92271632
78	MP0003763_abnormal_thymus_physiology	0.91439996
79	MP0009745_abnormal_behavioral_response	0.88009454
80	MP0005084_abnormal_gallbladder_morpholo	0.87680922
81	MP0005332_abnormal_amino_acid	0.87374180
82	MP0002272_abnormal_nervous_system	0.87084408
83	MP0002876_abnormal_thyroid_physiology	0.86330180
84	MP0005636_abnormal_mineral_homeostasis	0.85651585
85	MP0010386_abnormal_urinary_bladder	0.83369064
86	MP0000716_abnormal_immune_system	0.83257111
87	MP0005085_abnormal_gallbladder_physiolo	0.82639015
88	MP0003011_delayed_dark_adaptation	0.79176260
89	MP0002009_preneoplasia	0.78780740
90	MP0003638_abnormal_response/metabolism_	0.78451823
91	MP0002398_abnormal_bone_marrow	0.78208232
92	MP0002419_abnormal_innate_immunity	0.78092169
93	MP0008789_abnormal_olfactory_epithelium	0.77522399
94	MP0001756_abnormal_urination	0.77426120
95	MP0001486_abnormal_startle_reflex	0.76786214
96	MP0001765_abnormal_ion_homeostasis	0.76635662
97	MP0008469_abnormal_protein_level	0.75820776
98	MP0000383_abnormal_hair_follicle	0.74130078
99	MP0000689_abnormal_spleen_morphology	0.74045281
100	MP0008058_abnormal_DNA_repair	0.73251952

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital, generalized hypertrichosis (HP:0004540)	4.82496052
2	Acute necrotizing encephalopathy (HP:0006965)	4.45788650
3	Mitochondrial inheritance (HP:0001427)	4.23463347
4	Progressive macrocephaly (HP:0004481)	3.84644457
5	Abnormal mitochondria in muscle tissue (HP:0008316)	3.81955582
6	Acute encephalopathy (HP:0006846)	3.81573261
7	Increased CSF lactate (HP:0002490)	3.74786158
8	Lipid accumulation in hepatocytes (HP:0006561)	3.74201940
9	Increased hepatocellular lipid droplets (HP:0006565)	3.72453162
10	Hepatocellular necrosis (HP:0001404)	3.67415730
11	Congenital stationary night blindness (HP:0007642)	3.39139248
12	Pancreatic cysts (HP:0001737)	3.37748971
13	Pancreatic fibrosis (HP:0100732)	3.36928611
14	Hepatic necrosis (HP:0002605)	3.29289170
15	Abnormality of the prostate (HP:0008775)	3.26467885
16	IgG deficiency (HP:0004315)	3.10503874
17	Cerebral edema (HP:0002181)	2.99474446
18	Abolished electroretinogram (ERG) (HP:0000550)	2.97852926
19	Elevated erythrocyte sedimentation rate (HP:0003565)	2.93965661
20	3-Methylglutaconic aciduria (HP:0003535)	2.90651536
21	Renal Fanconi syndrome (HP:0001994)	2.87276909
22	Severe combined immunodeficiency (HP:0004430)	2.86961433
23	Molar tooth sign on MRI (HP:0002419)	2.85615407
24	Abnormality of midbrain morphology (HP:0002418)	2.85615407
25	Hypoproteinemia (HP:0003075)	2.76607437
26	Decreased central vision (HP:0007663)	2.68798410
27	Bile duct proliferation (HP:0001408)	2.67065069
28	Abnormal biliary tract physiology (HP:0012439)	2.67065069
29	Exertional dyspnea (HP:0002875)	2.66743822
30	Optic disc pallor (HP:0000543)	2.57188258
31	Increased intramyocellular lipid droplets (HP:0012240)	2.55379538
32	Hypothermia (HP:0002045)	2.54294302
33	True hermaphroditism (HP:0010459)	2.51770293
34	Polydipsia (HP:0001959)	2.47746305
35	Abnormal drinking behavior (HP:0030082)	2.47746305
36	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.46368575
37	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.46368575
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.46136446
39	Thyroiditis (HP:0100646)	2.42709227
40	Abnormal rod and cone electroretinograms (HP:0008323)	2.42056965
41	Abnormality of the renal cortex (HP:0011035)	2.35957963
42	Methylmalonic acidemia (HP:0002912)	2.35794916
43	Attenuation of retinal blood vessels (HP:0007843)	2.30906814
44	Increased muscle lipid content (HP:0009058)	2.28649615
45	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.27596829
46	Leukodystrophy (HP:0002415)	2.27251869
47	Woolly hair (HP:0002224)	2.24907947
48	Abnormality of DNA repair (HP:0003254)	2.24880576
49	Lactic acidosis (HP:0003128)	2.23650996
50	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23267521
51	Nephronophthisis (HP:0000090)	2.21422246
52	Reticulocytopenia (HP:0001896)	2.20745361
53	Abnormality of the renal medulla (HP:0100957)	2.20213956
54	Type 2 muscle fiber atrophy (HP:0003554)	2.20083230
55	Increased serum lactate (HP:0002151)	2.17971807
56	Abnormality of the axillary hair (HP:0100134)	2.15894601
57	Abnormality of secondary sexual hair (HP:0009888)	2.15894601
58	Prostate neoplasm (HP:0100787)	2.11356644
59	Aplastic anemia (HP:0001915)	2.10567682
60	Tubulointerstitial fibrosis (HP:0005576)	2.10364529
61	Cystic liver disease (HP:0006706)	2.08471505
62	Stomatitis (HP:0010280)	2.08363631
63	Respiratory failure (HP:0002878)	2.05741560
64	Combined immunodeficiency (HP:0005387)	2.04750414
65	Spastic paraparesis (HP:0002313)	2.03046026
66	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.03020701
67	Abnormality of alanine metabolism (HP:0010916)	2.03020701
68	Hyperalaninemia (HP:0003348)	2.03020701
69	Lethargy (HP:0001254)	2.03009123
70	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.01787786
71	Medial flaring of the eyebrow (HP:0010747)	1.96265994
72	Tubular atrophy (HP:0000092)	1.94225827
73	Abnormality of male internal genitalia (HP:0000022)	1.93709324
74	Chronic obstructive pulmonary disease (HP:0006510)	1.92801864
75	Obstructive lung disease (HP:0006536)	1.92801864
76	Panhypogammaglobulinemia (HP:0003139)	1.91858292
77	Abnormality of urine glucose concentration (HP:0011016)	1.90535133
78	Glycosuria (HP:0003076)	1.90535133
79	Hemoptysis (HP:0002105)	1.87674711
80	Polyuria (HP:0000103)	1.87125148
81	Pruritus (HP:0000989)	1.85620054
82	Sclerocornea (HP:0000647)	1.85474951
83	Macular degeneration (HP:0000608)	1.84194168
84	Abnormality of renal resorption (HP:0011038)	1.82425310
85	Generalized aminoaciduria (HP:0002909)	1.81806142
86	Supernumerary spleens (HP:0009799)	1.79109603
87	Muscle fiber atrophy (HP:0100295)	1.77473454
88	Type II lissencephaly (HP:0007260)	1.77390810
89	Pancytopenia (HP:0001876)	1.76503614
90	Stenosis of the external auditory canal (HP:0000402)	1.75529623
91	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.74355010
92	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.74213081
93	Methylmalonic aciduria (HP:0012120)	1.74143235
94	Asplenia (HP:0001746)	1.73135486
95	Short tibia (HP:0005736)	1.72468409
96	Congenital hepatic fibrosis (HP:0002612)	1.70493342
97	Hyperglycinemia (HP:0002154)	1.68705463
98	Type I transferrin isoform profile (HP:0003642)	1.68269336
99	Increased IgM level (HP:0003496)	1.66984525
100	Cerebral palsy (HP:0100021)	1.64136132

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	CDK19	3.37380817
2	BMPR2	3.12081256
3	ADRBK2	2.77323178
4	FRK	2.68875900
5	STK16	2.55155994
6	TLK1	2.46769898
7	NUAK1	2.34903396
8	MAP3K12	2.30003674
9	ZAK	2.28649913
10	GRK1	2.23676467
11	TAOK3	2.17365921
12	MAP4K2	2.10051127
13	BCKDK	2.04761448
14	VRK2	2.02694823
15	KDR	1.87657870
16	MYLK	1.79138245
17	TXK	1.71115806
18	OXSR1	1.60934046
19	TEC	1.53991919
20	ITK	1.53347504
21	KIT	1.51408746
22	INSRR	1.49743921
23	IKBKB	1.46621572
24	PASK	1.45942438
25	MAP4K1	1.38036840
26	WNK3	1.37376646
27	EIF2AK3	1.32245413
28	CSF1R	1.31099950
29	DAPK1	1.27608103
30	SYK	1.26867892
31	ERBB3	1.24768121
32	GRK6	1.23307546
33	RIPK4	1.21884871
34	TIE1	1.20867609
35	DYRK2	1.20269654
36	VRK1	1.18487281
37	MAP3K14	1.06643112
38	LYN	1.04633827
39	MAPK13	1.04274882
40	MUSK	1.03989105
41	PHKG2	0.99436185
42	PHKG1	0.99436185
43	DAPK3	0.97149740
44	BMPR1B	0.95616604
45	ILK	0.91477025
46	MKNK1	0.90958319
47	BTK	0.90772985
48	MKNK2	0.89067501
49	TRPM7	0.86741733
50	PIK3CG	0.84980323
51	FLT3	0.84614191
52	FES	0.84090348
53	RPS6KA5	0.83933285
54	CCNB1	0.83263819
55	BCR	0.81376162
56	PIK3CA	0.80069720
57	IKBKE	0.80024335
58	CDK8	0.79248252
59	OBSCN	0.76669857
60	MAP3K4	0.75421350
61	PTK2B	0.74545707
62	PRKCE	0.72182676
63	LCK	0.67953252
64	EIF2AK2	0.66919364
65	TRIM28	0.66266640
66	PLK4	0.64562793
67	TBK1	0.63562922
68	CSNK1G3	0.62615904
69	CSNK1G2	0.62460551
70	PLK2	0.62062513
71	JAK3	0.61765296
72	WNK4	0.60363742
73	GRK5	0.60327672
74	PINK1	0.58249415
75	MAPKAPK5	0.56496566
76	SCYL2	0.55945146
77	ADRBK1	0.55563728
78	MATK	0.55434755
79	ABL1	0.54756037
80	NEK1	0.53215499
81	IGF1R	0.51374239
82	STK39	0.50953069
83	PRKACA	0.49706873
84	PRKCQ	0.49262937
85	PRKCA	0.47624041
86	EGFR	0.47470246
87	DAPK2	0.46931148
88	ACVR1B	0.46676870
89	CAMKK2	0.46141549
90	CSNK1A1L	0.44765484
91	PKN1	0.44073892
92	PRKG1	0.42012245
93	CSNK1D	0.39692686
94	SRPK1	0.39308725
95	PRKACG	0.39146024
96	CAMK2A	0.38635568
97	CHUK	0.37834034
98	ERBB2	0.36583805
99	CDK3	0.36209607
100	MST4	0.35302079

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Asthma_Homo sapiens_hsa05310	5.03878499
2	Allograft rejection_Homo sapiens_hsa05330	4.05188813
3	Autoimmune thyroid disease_Homo sapiens_hsa05320	3.85866716
4	Graft-versus-host disease_Homo sapiens_hsa05332	3.81977648
5	Intestinal immune network for IgA production_Homo sapiens_hsa04672	3.65386521
6	Type I diabetes mellitus_Homo sapiens_hsa04940	3.29917466
7	Oxidative phosphorylation_Homo sapiens_hsa00190	3.15166523
8	Ribosome_Homo sapiens_hsa03010	2.46238651
9	Parkinsons disease_Homo sapiens_hsa05012	2.45860158
10	Proteasome_Homo sapiens_hsa03050	2.31119943
11	Antigen processing and presentation_Homo sapiens_hsa04612	2.13246417
12	Protein export_Homo sapiens_hsa03060	2.10812239
13	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	2.06031812
14	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.92609785
15	Rheumatoid arthritis_Homo sapiens_hsa05323	1.90942211
16	Viral myocarditis_Homo sapiens_hsa05416	1.72386123
17	Phototransduction_Homo sapiens_hsa04744	1.70362823
18	Caffeine metabolism_Homo sapiens_hsa00232	1.63676460
19	Alzheimers disease_Homo sapiens_hsa05010	1.61893916
20	RNA polymerase_Homo sapiens_hsa03020	1.59169597
21	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.54410310
22	Primary immunodeficiency_Homo sapiens_hsa05340	1.52065764
23	Huntingtons disease_Homo sapiens_hsa05016	1.51219668
24	Linoleic acid metabolism_Homo sapiens_hsa00591	1.41712591
25	Leishmaniasis_Homo sapiens_hsa05140	1.38511690
26	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.38099205
27	Cardiac muscle contraction_Homo sapiens_hsa04260	1.33948696
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.25189575
29	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.19884496
30	RNA degradation_Homo sapiens_hsa03018	1.17772791
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17097235
32	One carbon pool by folate_Homo sapiens_hsa00670	1.14092699
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.13860855
34	Hematopoietic cell lineage_Homo sapiens_hsa04640	1.09052985
35	Homologous recombination_Homo sapiens_hsa03440	1.09046189
36	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.05268244
37	Nitrogen metabolism_Homo sapiens_hsa00910	1.03534722
38	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99389511
39	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.94788461
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.87264015
41	Olfactory transduction_Homo sapiens_hsa04740	0.83798209
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.82701850
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78341917
44	Tryptophan metabolism_Homo sapiens_hsa00380	0.76245418
45	Pyrimidine metabolism_Homo sapiens_hsa00240	0.75714105
46	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.75017234
47	Collecting duct acid secretion_Homo sapiens_hsa04966	0.73520289
48	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.72941813
49	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.71862793
50	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.70846577
51	Regulation of autophagy_Homo sapiens_hsa04140	0.70397139
52	Glutathione metabolism_Homo sapiens_hsa00480	0.64817127
53	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.64414325
54	Ether lipid metabolism_Homo sapiens_hsa00565	0.63821709
55	Propanoate metabolism_Homo sapiens_hsa00640	0.63769179
56	Purine metabolism_Homo sapiens_hsa00230	0.62348081
57	Nucleotide excision repair_Homo sapiens_hsa03420	0.61507284
58	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.58052305
59	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.56973515
60	DNA replication_Homo sapiens_hsa03030	0.56932788
61	Taste transduction_Homo sapiens_hsa04742	0.54867230
62	Herpes simplex infection_Homo sapiens_hsa05168	0.51933322
63	Basal transcription factors_Homo sapiens_hsa03022	0.50462901
64	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.46830298
65	Mismatch repair_Homo sapiens_hsa03430	0.46424602
66	Butanoate metabolism_Homo sapiens_hsa00650	0.45249060
67	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.45182422
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.45141032
69	Toxoplasmosis_Homo sapiens_hsa05145	0.44658725
70	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42266477
71	Fat digestion and absorption_Homo sapiens_hsa04975	0.42166567
72	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.42124933
73	Spliceosome_Homo sapiens_hsa03040	0.40639509
74	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.39580178
75	RNA transport_Homo sapiens_hsa03013	0.38876243
76	Tuberculosis_Homo sapiens_hsa05152	0.38734670
77	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.37273123
78	Peroxisome_Homo sapiens_hsa04146	0.36494535
79	Morphine addiction_Homo sapiens_hsa05032	0.36413667
80	Retinol metabolism_Homo sapiens_hsa00830	0.35884666
81	Nicotine addiction_Homo sapiens_hsa05033	0.35876912
82	Phagosome_Homo sapiens_hsa04145	0.33120685
83	Metabolic pathways_Homo sapiens_hsa01100	0.31565512
84	Salivary secretion_Homo sapiens_hsa04970	0.30346059
85	African trypanosomiasis_Homo sapiens_hsa05143	0.30041009
86	Sulfur metabolism_Homo sapiens_hsa00920	0.29254686
87	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.29183604
88	Non-homologous end-joining_Homo sapiens_hsa03450	0.28985050
89	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.28627464
90	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.28405802
91	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.26702601
92	beta-Alanine metabolism_Homo sapiens_hsa00410	0.26616118
93	Sulfur relay system_Homo sapiens_hsa04122	0.24716527
94	Serotonergic synapse_Homo sapiens_hsa04726	0.22056067
95	GABAergic synapse_Homo sapiens_hsa04727	0.20902696
96	Fatty acid degradation_Homo sapiens_hsa00071	0.20876117
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.20309871
98	Glycerolipid metabolism_Homo sapiens_hsa00561	0.18610412
99	Circadian entrainment_Homo sapiens_hsa04713	0.17975651
100	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.17636192

RPL7P4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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