ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.58909747
2	DNA deamination (GO:0045006)	4.96170197
3	L-fucose catabolic process (GO:0042355)	4.46371262
4	fucose catabolic process (GO:0019317)	4.46371262
5	L-fucose metabolic process (GO:0042354)	4.46371262
6	cytochrome complex assembly (GO:0017004)	3.98210411
7	negative regulation of telomere maintenance (GO:0032205)	3.90045413
8	piRNA metabolic process (GO:0034587)	3.84697027
9	respiratory chain complex IV assembly (GO:0008535)	3.82570076
10	protein complex biogenesis (GO:0070271)	3.77983705
11	maturation of 5.8S rRNA (GO:0000460)	3.76964272
12	response to pheromone (GO:0019236)	3.76533853
13	platelet dense granule organization (GO:0060155)	3.66680326
14	mitochondrial respiratory chain complex assembly (GO:0033108)	3.54749256
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.50971323
16	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.44499949
17	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.44499949
18	indolalkylamine metabolic process (GO:0006586)	3.44082931
19	water-soluble vitamin biosynthetic process (GO:0042364)	3.42796361
20	ubiquinone biosynthetic process (GO:0006744)	3.42507384
21	tryptophan catabolic process (GO:0006569)	3.37689560
22	indole-containing compound catabolic process (GO:0042436)	3.37689560
23	indolalkylamine catabolic process (GO:0046218)	3.37689560
24	kynurenine metabolic process (GO:0070189)	3.36556555
25	detection of light stimulus involved in visual perception (GO:0050908)	3.36197517
26	detection of light stimulus involved in sensory perception (GO:0050962)	3.36197517
27	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	3.28157964
28	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.28005734
29	NADH dehydrogenase complex assembly (GO:0010257)	3.28005734
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.28005734
31	nonmotile primary cilium assembly (GO:0035058)	3.21688389
32	ubiquinone metabolic process (GO:0006743)	3.21664928
33	neural tube formation (GO:0001841)	3.19870036
34	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.16565091
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.10033466
36	regulation of cilium movement (GO:0003352)	3.08733699
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.07732963
38	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.03014828
39	protein-cofactor linkage (GO:0018065)	3.01640082
40	pyrimidine nucleobase catabolic process (GO:0006208)	2.99689982
41	rRNA catabolic process (GO:0016075)	2.97695635
42	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.96559780
43	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.93790863
44	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.88396577
45	proline transport (GO:0015824)	2.86628976
46	tryptophan metabolic process (GO:0006568)	2.86531922
47	pseudouridine synthesis (GO:0001522)	2.85999723
48	protein K11-linked deubiquitination (GO:0035871)	2.83630608
49	reflex (GO:0060004)	2.83416512
50	preassembly of GPI anchor in ER membrane (GO:0016254)	2.83103758
51	axoneme assembly (GO:0035082)	2.82132601
52	gamma-aminobutyric acid transport (GO:0015812)	2.79894337
53	negative regulation of interleukin-1 beta production (GO:0032691)	2.79418059
54	L-methionine salvage (GO:0071267)	2.77815231
55	L-methionine biosynthetic process (GO:0071265)	2.77815231
56	amino acid salvage (GO:0043102)	2.77815231
57	mannosylation (GO:0097502)	2.74983257
58	cornea development in camera-type eye (GO:0061303)	2.74648016
59	multicellular organism reproduction (GO:0032504)	2.74328767
60	positive regulation of prostaglandin secretion (GO:0032308)	2.73991993
61	protein polyglutamylation (GO:0018095)	2.71600944
62	protein neddylation (GO:0045116)	2.70530650
63	quinone biosynthetic process (GO:1901663)	2.70384460
64	kidney morphogenesis (GO:0060993)	2.68714600
65	negative regulation of mast cell activation (GO:0033004)	2.68623271
66	S-adenosylmethionine metabolic process (GO:0046500)	2.67075221
67	transmission of nerve impulse (GO:0019226)	2.66808820
68	negative regulation of interleukin-1 production (GO:0032692)	2.66226884
69	photoreceptor cell development (GO:0042461)	2.65525354
70	indole-containing compound metabolic process (GO:0042430)	2.65352707
71	amine catabolic process (GO:0009310)	2.63550525
72	cellular biogenic amine catabolic process (GO:0042402)	2.63550525
73	glycerophospholipid catabolic process (GO:0046475)	2.62388356
74	regulation of action potential (GO:0098900)	2.61485502
75	cellular ketone body metabolic process (GO:0046950)	2.61440999
76	nucleobase catabolic process (GO:0046113)	2.61375233
77	photoreceptor cell maintenance (GO:0045494)	2.59311891
78	neuronal action potential (GO:0019228)	2.58696715
79	tRNA processing (GO:0008033)	2.58275359
80	protein localization to cilium (GO:0061512)	2.58223663
81	synaptic transmission, cholinergic (GO:0007271)	2.58115290
82	negative regulation of heart rate (GO:0010459)	2.56381157
83	positive regulation of fatty acid transport (GO:2000193)	2.55982770
84	ATP synthesis coupled proton transport (GO:0015986)	2.52243592
85	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.52243592
86	nucleoside transmembrane transport (GO:1901642)	2.50804931
87	somite development (GO:0061053)	2.49995644
88	epithelial cilium movement (GO:0003351)	2.49947047
89	GPI anchor metabolic process (GO:0006505)	2.49627328
90	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.49512739
91	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.49309848
92	positive regulation of oligodendrocyte differentiation (GO:0048714)	2.49300327
93	cullin deneddylation (GO:0010388)	2.47847461
94	methionine biosynthetic process (GO:0009086)	2.44330061
95	electron transport chain (GO:0022900)	2.43354045
96	regulation of telomere maintenance (GO:0032204)	2.43136293
97	phosphatidylinositol acyl-chain remodeling (GO:0036149)	2.41641001
98	positive regulation of defense response to virus by host (GO:0002230)	2.41537416
99	ketone body metabolic process (GO:1902224)	2.40253423
100	reciprocal DNA recombination (GO:0035825)	2.40010523

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.14081768
2	VDR_22108803_ChIP-Seq_LS180_Human	3.27881320
3	EZH2_22144423_ChIP-Seq_EOC_Human	2.94015290
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.93001603
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.69942452
6	GBX2_23144817_ChIP-Seq_PC3_Human	2.49554781
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.45776086
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44980552
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.36804955
10	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.22284445
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.07510673
12	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.00656708
13	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.00045539
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.93398437
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.91878533
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.91476425
17	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.91197960
18	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88965186
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88175097
20	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.87950094
21	FUS_26573619_Chip-Seq_HEK293_Human	1.83852059
22	P300_19829295_ChIP-Seq_ESCs_Human	1.82734952
23	ER_23166858_ChIP-Seq_MCF-7_Human	1.81962678
24	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.68633054
25	EWS_26573619_Chip-Seq_HEK293_Human	1.68530614
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.64876651
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.63807650
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.61834873
29	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.55512563
30	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.50652224
31	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.50139378
32	BCAT_22108803_ChIP-Seq_LS180_Human	1.50071336
33	MYC_18940864_ChIP-ChIP_HL60_Human	1.49385521
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.48245363
35	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.46311307
36	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.46225172
37	TCF4_22108803_ChIP-Seq_LS180_Human	1.39554575
38	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.37260888
39	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.37260888
40	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.37154548
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.37154548
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.36525935
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36525935
44	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.36260539
45	TAF15_26573619_Chip-Seq_HEK293_Human	1.36092947
46	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.35995367
47	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35185409
48	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.34046374
49	SOX2_19829295_ChIP-Seq_ESCs_Human	1.32825453
50	NANOG_19829295_ChIP-Seq_ESCs_Human	1.32825453
51	NCOR_22424771_ChIP-Seq_293T_Human	1.30227714
52	TCF4_23295773_ChIP-Seq_U87_Human	1.29822785
53	RNF2_27304074_Chip-Seq_NSC_Mouse	1.28959445
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.27937399
55	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25317554
56	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25235807
57	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.23831775
58	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23808800
59	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23695267
60	STAT3_23295773_ChIP-Seq_U87_Human	1.22704628
61	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.22595807
62	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.22023634
63	AR_20517297_ChIP-Seq_VCAP_Human	1.22010529
64	HOXB7_26014856_ChIP-Seq_BT474_Human	1.21758497
65	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.20919374
66	VDR_23849224_ChIP-Seq_CD4+_Human	1.19425220
67	AR_25329375_ChIP-Seq_VCAP_Human	1.18176679
68	AR_21572438_ChIP-Seq_LNCaP_Human	1.18165650
69	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.17828575
70	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17324824
71	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.17026308
72	ERA_21632823_ChIP-Seq_H3396_Human	1.15905757
73	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15403275
74	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14427316
75	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.14147801
76	ELK1_19687146_ChIP-ChIP_HELA_Human	1.12745824
77	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11083168
78	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10700785
79	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.10419141
80	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09904951
81	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09177598
82	SMAD4_21799915_ChIP-Seq_A2780_Human	1.09041833
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.09023913
84	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.08340668
85	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.08249591
86	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.07999140
87	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.06195016
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.05652396
89	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.04911493
90	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.03250298
91	NANOG_20526341_ChIP-Seq_ESCs_Human	1.01974819
92	MYC_19829295_ChIP-Seq_ESCs_Human	1.01661653
93	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99430251
94	TAF2_19829295_ChIP-Seq_ESCs_Human	0.99319140
95	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.98975377
96	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.97417560
97	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.96239328
98	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.94121033
99	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.93817218
100	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.93405172

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003195_calcinosis	3.19771137
2	MP0002102_abnormal_ear_morphology	2.80043361
3	MP0008877_abnormal_DNA_methylation	2.76876083
4	MP0003136_yellow_coat_color	2.43461496
5	MP0006292_abnormal_olfactory_placode	2.40447056
6	MP0003646_muscle_fatigue	2.38286146
7	MP0001968_abnormal_touch/_nociception	2.36824080
8	MP0005551_abnormal_eye_electrophysiolog	2.24889046
9	MP0000372_irregular_coat_pigmentation	2.21517555
10	MP0002736_abnormal_nociception_after	2.21141324
11	MP0003011_delayed_dark_adaptation	2.21042759
12	MP0004142_abnormal_muscle_tone	2.14215340
13	MP0003880_abnormal_central_pattern	2.13509327
14	MP0006072_abnormal_retinal_apoptosis	2.09985901
15	MP0008875_abnormal_xenobiotic_pharmacok	2.05993889
16	MP0009046_muscle_twitch	2.04736769
17	MP0004147_increased_porphyrin_level	2.00842129
18	MP0004885_abnormal_endolymph	2.00432510
19	MP0008872_abnormal_physiological_respon	1.99519092
20	MP0001984_abnormal_olfaction	1.91503670
21	MP0009745_abnormal_behavioral_response	1.89845241
22	MP0002876_abnormal_thyroid_physiology	1.87024131
23	MP0005084_abnormal_gallbladder_morpholo	1.86475272
24	MP0006276_abnormal_autonomic_nervous	1.83265092
25	MP0002837_dystrophic_cardiac_calcinosis	1.78159577
26	MP0005253_abnormal_eye_physiology	1.75238251
27	MP0002735_abnormal_chemical_nociception	1.72725513
28	MP0002272_abnormal_nervous_system	1.66883532
29	MP0001986_abnormal_taste_sensitivity	1.63202114
30	MP0005646_abnormal_pituitary_gland	1.61060074
31	MP0004043_abnormal_pH_regulation	1.56170830
32	MP0001501_abnormal_sleep_pattern	1.51348791
33	MP0002938_white_spotting	1.50339349
34	MP0002653_abnormal_ependyma_morphology	1.48770174
35	MP0003787_abnormal_imprinting	1.46291817
36	MP0005645_abnormal_hypothalamus_physiol	1.44569658
37	MP0004145_abnormal_muscle_electrophysio	1.44095300
38	MP0001970_abnormal_pain_threshold	1.40081245
39	MP0002733_abnormal_thermal_nociception	1.39539770
40	MP0002572_abnormal_emotion/affect_behav	1.33911301
41	MP0001919_abnormal_reproductive_system	1.33163568
42	MP0001486_abnormal_startle_reflex	1.29790215
43	MP0005389_reproductive_system_phenotype	1.29631892
44	MP0002557_abnormal_social/conspecific_i	1.28803805
45	MP0002277_abnormal_respiratory_mucosa	1.28470856
46	MP0000631_abnormal_neuroendocrine_gland	1.27251812
47	MP0005410_abnormal_fertilization	1.27013041
48	MP0002638_abnormal_pupillary_reflex	1.25209022
49	MP0002064_seizures	1.23884103
50	MP0001529_abnormal_vocalization	1.23667321
51	MP0001485_abnormal_pinna_reflex	1.23226359
52	MP0004133_heterotaxia	1.22730565
53	MP0004742_abnormal_vestibular_system	1.21601722
54	MP0002063_abnormal_learning/memory/cond	1.21557922
55	MP0002138_abnormal_hepatobiliary_system	1.21149892
56	MP0008789_abnormal_olfactory_epithelium	1.20359878
57	MP0005386_behavior/neurological_phenoty	1.20013495
58	MP0004924_abnormal_behavior	1.20013495
59	MP0003635_abnormal_synaptic_transmissio	1.16569982
60	MP0000427_abnormal_hair_cycle	1.15654670
61	MP0008995_early_reproductive_senescence	1.12433628
62	MP0002751_abnormal_autonomic_nervous	1.07721679
63	MP0002160_abnormal_reproductive_system	1.05174558
64	MP0003718_maternal_effect	1.04023827
65	MP0009764_decreased_sensitivity_to	1.03814769
66	MP0005083_abnormal_biliary_tract	1.03506757
67	MP0005195_abnormal_posterior_eye	0.99469229
68	MP0001905_abnormal_dopamine_level	0.97417721
69	MP0002067_abnormal_sensory_capabilities	0.97388778
70	MP0002184_abnormal_innervation	0.96468091
71	MP0000778_abnormal_nervous_system	0.93157668
72	MP0003878_abnormal_ear_physiology	0.93098576
73	MP0005377_hearing/vestibular/ear_phenot	0.93098576
74	MP0002752_abnormal_somatic_nervous	0.92433691
75	MP0005394_taste/olfaction_phenotype	0.91748674
76	MP0005499_abnormal_olfactory_system	0.91748674
77	MP0003283_abnormal_digestive_organ	0.91585338
78	MP0003137_abnormal_impulse_conducting	0.90306424
79	MP0005174_abnormal_tail_pigmentation	0.87202337
80	MP0008775_abnormal_heart_ventricle	0.86616120
81	MP0002095_abnormal_skin_pigmentation	0.86592712
82	MP0002282_abnormal_trachea_morphology	0.85639740
83	MP0000230_abnormal_systemic_arterial	0.85217940
84	MP0003252_abnormal_bile_duct	0.85114110
85	MP0005423_abnormal_somatic_nervous	0.82474596
86	MP0003698_abnormal_male_reproductive	0.82026585
87	MP0010386_abnormal_urinary_bladder	0.81064637
88	MP0002734_abnormal_mechanical_nocicepti	0.80126008
89	MP0006036_abnormal_mitochondrial_physio	0.79714245
90	MP0005171_absent_coat_pigmentation	0.79237701
91	MP0005636_abnormal_mineral_homeostasis	0.76337319
92	MP0001963_abnormal_hearing_physiology	0.75596867
93	MP0005075_abnormal_melanosome_morpholog	0.75093395
94	MP0000049_abnormal_middle_ear	0.74640239
95	MP0002234_abnormal_pharynx_morphology	0.73849020
96	MP0002210_abnormal_sex_determination	0.73522920
97	MP0001188_hyperpigmentation	0.73488756
98	MP0000026_abnormal_inner_ear	0.73197942
99	MP0001324_abnormal_eye_pigmentation	0.72553408
100	MP0008058_abnormal_DNA_repair	0.72476432

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.06750980
2	Congenital stationary night blindness (HP:0007642)	3.88182149
3	Pancreatic fibrosis (HP:0100732)	3.75769956
4	Abnormality of midbrain morphology (HP:0002418)	3.53314142
5	Molar tooth sign on MRI (HP:0002419)	3.53314142
6	True hermaphroditism (HP:0010459)	3.38987446
7	Type II lissencephaly (HP:0007260)	3.36208473
8	Nephronophthisis (HP:0000090)	3.35787359
9	Abnormality of the renal cortex (HP:0011035)	3.15225470
10	Abnormal rod and cone electroretinograms (HP:0008323)	3.12429511
11	Pendular nystagmus (HP:0012043)	3.01133304
12	Abnormality of the renal medulla (HP:0100957)	2.95176421
13	Abolished electroretinogram (ERG) (HP:0000550)	2.93239698
14	Medial flaring of the eyebrow (HP:0010747)	2.92845853
15	Attenuation of retinal blood vessels (HP:0007843)	2.81384079
16	Acute necrotizing encephalopathy (HP:0006965)	2.76251228
17	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.70828115
18	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.69870229
19	Abnormality of alanine metabolism (HP:0010916)	2.69870229
20	Hyperalaninemia (HP:0003348)	2.69870229
21	Tubular atrophy (HP:0000092)	2.64052556
22	Mitochondrial inheritance (HP:0001427)	2.54690941
23	Abnormal drinking behavior (HP:0030082)	2.49703428
24	Polydipsia (HP:0001959)	2.49703428
25	Lissencephaly (HP:0001339)	2.48358021
26	Keratoconus (HP:0000563)	2.48027195
27	Increased corneal curvature (HP:0100692)	2.48027195
28	Acute encephalopathy (HP:0006846)	2.47780569
29	Progressive macrocephaly (HP:0004481)	2.46586000
30	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.44902573
31	Increased CSF lactate (HP:0002490)	2.39788306
32	Abnormal mitochondria in muscle tissue (HP:0008316)	2.36237138
33	Inability to walk (HP:0002540)	2.35810664
34	Gait imbalance (HP:0002141)	2.33260961
35	Decreased central vision (HP:0007663)	2.30519702
36	Pachygyria (HP:0001302)	2.27695192
37	Hepatocellular necrosis (HP:0001404)	2.27069693
38	Cystic liver disease (HP:0006706)	2.26848599
39	Renal cortical cysts (HP:0000803)	2.26385925
40	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.26166952
41	Absent/shortened dynein arms (HP:0200106)	2.26166952
42	Congenital primary aphakia (HP:0007707)	2.24795393
43	Polyuria (HP:0000103)	2.23582148
44	Optic disc pallor (HP:0000543)	2.21263103
45	Hyperventilation (HP:0002883)	2.19012452
46	Congenital, generalized hypertrichosis (HP:0004540)	2.15388859
47	Genetic anticipation (HP:0003743)	2.13505109
48	Concave nail (HP:0001598)	2.13475705
49	Hepatic necrosis (HP:0002605)	2.13441903
50	Agitation (HP:0000713)	2.12488868
51	Abnormality of the labia minora (HP:0012880)	2.06679612
52	Progressive inability to walk (HP:0002505)	2.06252191
53	Retinal dysplasia (HP:0007973)	2.06002545
54	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.05891947
55	Sclerocornea (HP:0000647)	2.05613013
56	Nephrogenic diabetes insipidus (HP:0009806)	2.05108936
57	Chronic hepatic failure (HP:0100626)	2.02441527
58	3-Methylglutaconic aciduria (HP:0003535)	2.02157621
59	Hyperglycinuria (HP:0003108)	2.00935211
60	Cerebellar dysplasia (HP:0007033)	2.00521700
61	Optic nerve hypoplasia (HP:0000609)	1.98260911
62	Progressive cerebellar ataxia (HP:0002073)	1.98106380
63	Stomach cancer (HP:0012126)	1.97553747
64	Methylmalonic acidemia (HP:0002912)	1.96942845
65	Severe muscular hypotonia (HP:0006829)	1.96703293
66	Hyperglycinemia (HP:0002154)	1.96558898
67	Genital tract atresia (HP:0001827)	1.92942364
68	Stomatitis (HP:0010280)	1.91555301
69	Congenital hepatic fibrosis (HP:0002612)	1.91153233
70	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.88009425
71	Anophthalmia (HP:0000528)	1.87832564
72	Postaxial foot polydactyly (HP:0001830)	1.87578526
73	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87338913
74	Male pseudohermaphroditism (HP:0000037)	1.86351965
75	Anencephaly (HP:0002323)	1.86290261
76	Hypomagnesemia (HP:0002917)	1.85773826
77	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.82786136
78	Patellar aplasia (HP:0006443)	1.82777438
79	Furrowed tongue (HP:0000221)	1.82743150
80	Vaginal atresia (HP:0000148)	1.82627744
81	Bony spicule pigmentary retinopathy (HP:0007737)	1.82134666
82	Large for gestational age (HP:0001520)	1.82017989
83	Asplenia (HP:0001746)	1.81836907
84	Abnormal respiratory motile cilium morphology (HP:0005938)	1.80769821
85	Abnormal respiratory epithelium morphology (HP:0012253)	1.80769821
86	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.79756021
87	Abnormal number of erythroid precursors (HP:0012131)	1.77475950
88	Rib fusion (HP:0000902)	1.76742257
89	Aplasia/Hypoplasia of the fovea (HP:0008060)	1.76472024
90	Hypoplasia of the fovea (HP:0007750)	1.76472024
91	Increased serum lactate (HP:0002151)	1.76471588
92	Abnormality of glycine metabolism (HP:0010895)	1.76245756
93	Abnormality of serine family amino acid metabolism (HP:0010894)	1.76245756
94	Hemiparesis (HP:0001269)	1.75073192
95	Methylmalonic aciduria (HP:0012120)	1.74577632
96	Aplasia/Hypoplasia of the patella (HP:0006498)	1.74423215
97	Lethargy (HP:0001254)	1.73716769
98	Abnormal urine output (HP:0012590)	1.73639257
99	Constricted visual fields (HP:0001133)	1.73223668
100	Abnormal pancreas size (HP:0012094)	1.73205323

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	3.33728328
2	ADRBK2	3.22864155
3	MAP4K2	3.09633704
4	NUAK1	2.74700890
5	ZAK	2.74144735
6	GRK1	2.55683637
7	CASK	2.55115662
8	WNK4	2.51163205
9	BMPR1B	2.44036960
10	INSRR	2.33380027
11	PINK1	2.31614658
12	WNK3	2.18859830
13	TAOK3	2.12918175
14	TXK	2.03727483
15	ACVR1B	1.98179855
16	MAP3K4	1.98094668
17	MAPK13	1.83003209
18	TLK1	1.80270927
19	MARK1	1.75575735
20	OXSR1	1.72595144
21	CAMKK2	1.71134869
22	STK16	1.64236632
23	STK39	1.60940859
24	DAPK2	1.48684422
25	MAP2K7	1.47758067
26	DYRK2	1.40701997
27	TRIM28	1.40697131
28	PRKCI	1.32223332
29	PRKCG	1.24719056
30	TNIK	1.22340285
31	PAK3	1.14030608
32	MAP4K1	1.13085984
33	EIF2AK3	1.04150920
34	MAPKAPK3	1.03502890
35	BCKDK	1.02974040
36	BMPR2	0.99151933
37	PLK4	0.96996123
38	ADRBK1	0.95326727
39	MUSK	0.92331885
40	CSNK1G2	0.88675366
41	CSNK1G3	0.88454923
42	PLK2	0.88400581
43	PNCK	0.86846714
44	EPHA4	0.85856384
45	MAP3K9	0.82384312
46	PRKCE	0.81660454
47	PRKCQ	0.81242821
48	TAF1	0.78810960
49	VRK2	0.78777189
50	CSNK1G1	0.76059820
51	PHKG1	0.75535732
52	PHKG2	0.75535732
53	STK38L	0.74579796
54	VRK1	0.72301592
55	TEC	0.72230852
56	TGFBR1	0.71439171
57	NTRK2	0.67767689
58	CSNK1A1L	0.65538442
59	ERBB3	0.63510307
60	BRSK2	0.63374422
61	NTRK3	0.63177199
62	IKBKB	0.58086873
63	KIT	0.57923959
64	TIE1	0.57397553
65	CAMKK1	0.55358221
66	CDK19	0.53126297
67	MKNK2	0.51765788
68	PTK2B	0.49811412
69	RPS6KA5	0.48979039
70	PRKACA	0.48306027
71	TYRO3	0.48011817
72	CSNK1A1	0.47356153
73	PRKCZ	0.46532506
74	CAMK2A	0.45622255
75	FLT3	0.45244240
76	ITK	0.44944096
77	STK3	0.42480150
78	CAMK1	0.41140665
79	LIMK1	0.40700436
80	TSSK6	0.40420691
81	MAPKAPK5	0.40380631
82	AKT3	0.40188086
83	PRKCA	0.39428101
84	BCR	0.39248866
85	MAP2K6	0.38647561
86	OBSCN	0.38490753
87	PIK3CG	0.37877683
88	MAP2K4	0.37538122
89	PRKCD	0.36949146
90	SYK	0.35096653
91	GRK7	0.34935351
92	ATR	0.34426503
93	GRK6	0.34308119
94	PIK3CA	0.34151787
95	PLK3	0.34046754
96	DAPK3	0.33065494
97	CSNK1D	0.32163894
98	TNK2	0.31888903
99	NME1	0.30805563
100	MKNK1	0.30632401

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.95847595
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.93065580
3	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.52002376
4	Phototransduction_Homo sapiens_hsa04744	2.47238276
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.45501069
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.29667470
7	Parkinsons disease_Homo sapiens_hsa05012	2.29089153
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.25316118
9	Protein export_Homo sapiens_hsa03060	2.21036044
10	Nitrogen metabolism_Homo sapiens_hsa00910	2.09420074
11	Butanoate metabolism_Homo sapiens_hsa00650	2.07771636
12	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.96181400
13	Nicotine addiction_Homo sapiens_hsa05033	1.90203820
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.89113143
15	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81442822
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.75616934
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.72000366
18	Basal transcription factors_Homo sapiens_hsa03022	1.69419540
19	Homologous recombination_Homo sapiens_hsa03440	1.64915539
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.64628926
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.52421656
22	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.51556695
23	Ribosome_Homo sapiens_hsa03010	1.48671857
24	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.48620524
25	Asthma_Homo sapiens_hsa05310	1.46088199
26	One carbon pool by folate_Homo sapiens_hsa00670	1.45637870
27	Alzheimers disease_Homo sapiens_hsa05010	1.43540702
28	Huntingtons disease_Homo sapiens_hsa05016	1.41957289
29	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41434268
30	RNA degradation_Homo sapiens_hsa03018	1.40595645
31	Cardiac muscle contraction_Homo sapiens_hsa04260	1.39791558
32	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.37672502
33	Propanoate metabolism_Homo sapiens_hsa00640	1.35855952
34	Caffeine metabolism_Homo sapiens_hsa00232	1.35244661
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34506313
36	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.31750935
37	RNA polymerase_Homo sapiens_hsa03020	1.30014444
38	Proteasome_Homo sapiens_hsa03050	1.27007514
39	Taste transduction_Homo sapiens_hsa04742	1.18724780
40	Chemical carcinogenesis_Homo sapiens_hsa05204	1.16825164
41	Olfactory transduction_Homo sapiens_hsa04740	1.16300336
42	Regulation of autophagy_Homo sapiens_hsa04140	1.16202002
43	Peroxisome_Homo sapiens_hsa04146	1.15520815
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.09087976
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.06923695
46	Morphine addiction_Homo sapiens_hsa05032	1.06248107
47	Sulfur relay system_Homo sapiens_hsa04122	1.05833518
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.03707887
49	Graft-versus-host disease_Homo sapiens_hsa05332	0.99148351
50	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.96489701
51	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95481567
52	Retinol metabolism_Homo sapiens_hsa00830	0.90687000
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.90631901
54	Allograft rejection_Homo sapiens_hsa05330	0.90464846
55	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.89322840
56	Sulfur metabolism_Homo sapiens_hsa00920	0.87898757
57	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86296170
58	Type I diabetes mellitus_Homo sapiens_hsa04940	0.85954220
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.84886438
60	Steroid biosynthesis_Homo sapiens_hsa00100	0.84579599
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.84372005
62	GABAergic synapse_Homo sapiens_hsa04727	0.82489971
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.78884665
64	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.78008826
65	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.75570016
66	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.75292924
67	Serotonergic synapse_Homo sapiens_hsa04726	0.73980066
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.73356063
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72861460
70	Glutamatergic synapse_Homo sapiens_hsa04724	0.68979113
71	Tyrosine metabolism_Homo sapiens_hsa00350	0.67438231
72	Insulin secretion_Homo sapiens_hsa04911	0.66069570
73	Fatty acid degradation_Homo sapiens_hsa00071	0.65906390
74	Glycerolipid metabolism_Homo sapiens_hsa00561	0.65717794
75	Metabolic pathways_Homo sapiens_hsa01100	0.63545468
76	Circadian entrainment_Homo sapiens_hsa04713	0.60652805
77	Salivary secretion_Homo sapiens_hsa04970	0.59656835
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.57518274
79	Purine metabolism_Homo sapiens_hsa00230	0.57107986
80	Mineral absorption_Homo sapiens_hsa04978	0.56905394
81	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.55564415
82	Pyrimidine metabolism_Homo sapiens_hsa00240	0.55195543
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.55163227
84	ABC transporters_Homo sapiens_hsa02010	0.53938741
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53580420
86	Primary immunodeficiency_Homo sapiens_hsa05340	0.53495486
87	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52984484
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.50163542
89	Fatty acid elongation_Homo sapiens_hsa00062	0.49532423
90	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.47546936
91	Fatty acid metabolism_Homo sapiens_hsa01212	0.46375914
92	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.43627929
93	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42196449
94	RNA transport_Homo sapiens_hsa03013	0.41883241
95	Histidine metabolism_Homo sapiens_hsa00340	0.41443487
96	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.38172898
97	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36527641
98	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.34223580
99	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.33644627
100	Nucleotide excision repair_Homo sapiens_hsa03420	0.32221714

RPL7P41

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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