ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	intra-S DNA damage checkpoint (GO:0031573)	9.45515391
2	mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)	8.90225482
3	positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902110	8.90225482
4	synapsis (GO:0007129)	7.70795390
5	regulation of transforming growth factor beta2 production (GO:0032909)	7.16761595
6	piRNA metabolic process (GO:0034587)	7.05587639
7	male meiosis (GO:0007140)	7.01937105
8	spliceosomal tri-snRNP complex assembly (GO:0000244)	6.71478535
9	male meiosis I (GO:0007141)	6.23927556
10	positive regulation of mitochondrial membrane permeability (GO:0035794)	6.09708873
11	chromosome organization involved in meiosis (GO:0070192)	5.89665463
12	DNA methylation involved in gamete generation (GO:0043046)	5.85071609
13	ribosome assembly (GO:0042255)	5.46565925
14	UDP-N-acetylglucosamine metabolic process (GO:0006047)	5.36494176
15	DNA synthesis involved in DNA repair (GO:0000731)	5.10829300
16	meiotic nuclear division (GO:0007126)	4.97434221
17	meiosis I (GO:0007127)	4.73757579
18	regulation of mitochondrial membrane permeability involved in apoptotic process (GO:1902108)	4.70618241
19	regulation of RIG-I signaling pathway (GO:0039535)	4.67924207
20	synaptonemal complex assembly (GO:0007130)	4.67790744
21	reciprocal DNA recombination (GO:0035825)	4.49175860
22	reciprocal meiotic recombination (GO:0007131)	4.49175860
23	synaptonemal complex organization (GO:0070193)	4.48645588
24	DNA double-strand break processing (GO:0000729)	4.46092867
25	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	4.41139640
26	positive regulation of transforming growth factor beta production (GO:0071636)	4.39756974
27	positive regulation of mRNA catabolic process (GO:0061014)	4.31589255
28	cell wall macromolecule metabolic process (GO:0044036)	4.24378295
29	aspartate family amino acid catabolic process (GO:0009068)	4.24079286
30	macrophage differentiation (GO:0030225)	4.19236708
31	meiotic cell cycle process (GO:1903046)	4.15985819
32	positive regulation of translational initiation (GO:0045948)	4.01554821
33	activated T cell proliferation (GO:0050798)	4.00945009
34	spermatid development (GO:0007286)	3.95349797
35	nucleotide-sugar biosynthetic process (GO:0009226)	3.90101273
36	proteasome assembly (GO:0043248)	3.89643945
37	gene silencing by RNA (GO:0031047)	3.89085960
38	glucosamine-containing compound catabolic process (GO:1901072)	3.83278092
39	inositol phosphate catabolic process (GO:0071545)	3.70326732
40	DNA replication-dependent nucleosome assembly (GO:0006335)	3.70269979
41	DNA replication-dependent nucleosome organization (GO:0034723)	3.70269979
42	nuclear pore complex assembly (GO:0051292)	3.61106548
43	sister chromatid cohesion (GO:0007062)	3.59770207
44	regulation of mRNA catabolic process (GO:0061013)	3.59000540
45	histone exchange (GO:0043486)	3.54742879
46	cellular response to arsenic-containing substance (GO:0071243)	3.53820760
47	nuclear pore organization (GO:0006999)	3.53662000
48	photoreceptor cell maintenance (GO:0045494)	3.48712219
49	positive regulation of interferon-beta production (GO:0032728)	3.46310044
50	dolichol-linked oligosaccharide biosynthetic process (GO:0006488)	3.41987623
51	attachment of spindle microtubules to kinetochore (GO:0008608)	3.38910239
52	positive regulation of interferon-alpha production (GO:0032727)	3.37838046
53	regulation of meiosis I (GO:0060631)	3.36034946
54	regulation of helicase activity (GO:0051095)	3.34804591
55	regulation of interferon-alpha production (GO:0032647)	3.33939301
56	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.29196864
57	protein localization to cell surface (GO:0034394)	3.24325561
58	resolution of meiotic recombination intermediates (GO:0000712)	3.22351545
59	acrosome reaction (GO:0007340)	3.21440051
60	potassium ion export (GO:0071435)	3.20289743
61	cellular ketone body metabolic process (GO:0046950)	3.19969009
62	intraciliary transport (GO:0042073)	3.15334266
63	protein-chromophore linkage (GO:0018298)	3.14475366
64	necroptotic process (GO:0070266)	3.13057613
65	centriole assembly (GO:0098534)	3.12513372
66	positive regulation of glycolytic process (GO:0045821)	3.12382101
67	positive regulation of mRNA metabolic process (GO:1903313)	3.09076259
68	histone H2A acetylation (GO:0043968)	3.02460624
69	positive regulation of toll-like receptor signaling pathway (GO:0034123)	3.01710483
70	positive regulation of T cell cytokine production (GO:0002726)	2.99925830
71	negative regulation of cell cycle arrest (GO:0071157)	2.98652486
72	sperm motility (GO:0030317)	2.95330513
73	epithelial cilium movement (GO:0003351)	2.92230641
74	DNA catabolic process, exonucleolytic (GO:0000738)	2.89510667
75	centriole replication (GO:0007099)	2.89290901
76	regulation of interferon-beta production (GO:0032648)	2.88868713
77	positive regulation of histone H3-K4 methylation (GO:0051571)	2.88371483
78	polyol catabolic process (GO:0046174)	2.86245336
79	programmed necrotic cell death (GO:0097300)	2.84746970
80	nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)	2.83081807
81	binding of sperm to zona pellucida (GO:0007339)	2.82680507
82	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.81550258
83	3-UTR-mediated mRNA stabilization (GO:0070935)	2.80936341
84	negative regulation of cAMP-mediated signaling (GO:0043951)	2.79605346
85	aspartate family amino acid metabolic process (GO:0009066)	2.78021126
86	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.77800303
87	ketone body metabolic process (GO:1902224)	2.76389889
88	amino acid salvage (GO:0043102)	2.72346893
89	L-methionine salvage (GO:0071267)	2.72346893
90	L-methionine biosynthetic process (GO:0071265)	2.72346893
91	RNA destabilization (GO:0050779)	2.69459329
92	regulation of double-strand break repair via homologous recombination (GO:0010569)	2.69372519
93	relaxation of smooth muscle (GO:0044557)	2.68270088
94	blastocyst development (GO:0001824)	2.66804848
95	tongue development (GO:0043586)	2.63631273
96	sperm-egg recognition (GO:0035036)	2.62573807
97	negative regulation of DNA recombination (GO:0045910)	2.61965336
98	pore complex assembly (GO:0046931)	2.61172586
99	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.60705173
100	inositol phosphate dephosphorylation (GO:0046855)	2.60705173

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	5.76196655
2	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	5.11405495
3	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.57153974
4	IGF1R_20145208_ChIP-Seq_DFB_Human	4.56872055
5	GATA1_22025678_ChIP-Seq_K562_Human	3.79580599
6	E2F7_22180533_ChIP-Seq_HELA_Human	3.20192616
7	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00840034
8	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.80357486
9	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64938099
10	VDR_22108803_ChIP-Seq_LS180_Human	2.45286781
11	VDR_23849224_ChIP-Seq_CD4+_Human	2.34606935
12	SMAD_19615063_ChIP-ChIP_OVARY_Human	2.25705782
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.22459311
14	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.19491971
15	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.08459729
16	EWS_26573619_Chip-Seq_HEK293_Human	2.07305857
17	IRF1_19129219_ChIP-ChIP_H3396_Human	2.03585064
18	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.99264410
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.99020457
20	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.92155949
21	FUS_26573619_Chip-Seq_HEK293_Human	1.91462685
22	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.74487853
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.68630711
24	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.64956928
25	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.62622785
26	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.61100154
27	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.60249784
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.58840760
29	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.58387267
30	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.57894042
31	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55370221
32	ELK1_19687146_ChIP-ChIP_HELA_Human	1.52235403
33	HOXB7_26014856_ChIP-Seq_BT474_Human	1.50248465
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.48773937
35	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.44564607
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.43827861
37	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.41444322
38	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.40312603
39	FOXP3_21729870_ChIP-Seq_TREG_Human	1.39947168
40	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.36196092
41	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.32813667
42	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.30851891
43	AR_20517297_ChIP-Seq_VCAP_Human	1.30588225
44	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.29888523
45	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.28664402
46	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.27502368
47	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.25080104
48	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.24961562
49	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.24648649
50	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.23791308
51	STAT3_23295773_ChIP-Seq_U87_Human	1.23181685
52	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21861350
53	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.21492060
54	TCF4_23295773_ChIP-Seq_U87_Human	1.21482815
55	MYC_18940864_ChIP-ChIP_HL60_Human	1.20694129
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.17257667
57	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.15068284
58	GATA3_26560356_Chip-Seq_TH2_Human	1.14107739
59	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.13137308
60	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.13137308
61	RUNX2_22187159_ChIP-Seq_PCA_Human	1.12870263
62	TP53_22573176_ChIP-Seq_HFKS_Human	1.12719159
63	ERA_21632823_ChIP-Seq_H3396_Human	1.11653587
64	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.08133427
65	RNF2_27304074_Chip-Seq_NSC_Mouse	1.06956464
66	SMAD4_21799915_ChIP-Seq_A2780_Human	1.06736465
67	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.05412323
68	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.04369499
69	BCAT_22108803_ChIP-Seq_LS180_Human	1.03808469
70	P300_19829295_ChIP-Seq_ESCs_Human	1.03707324
71	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00842146
72	CBP_20019798_ChIP-Seq_JUKART_Human	1.00842146
73	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.00678939
74	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.98350207
75	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.96550085
76	GATA3_26560356_Chip-Seq_TH1_Human	0.96440309
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.96173460
78	NCOR_22424771_ChIP-Seq_293T_Human	0.94955653
79	RAC3_21632823_ChIP-Seq_H3396_Human	0.94321546
80	HOXB4_20404135_ChIP-ChIP_EML_Mouse	0.92861954
81	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.92242620
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.91320739
83	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.90955389
84	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.90955389
85	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.90007609
86	CDX2_22108803_ChIP-Seq_LS180_Human	0.89974256
87	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.88746184
88	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.87949381
89	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87783194
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.87630581
91	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.87467309
92	EZH2_27294783_Chip-Seq_NPCs_Mouse	0.87328574
93	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	0.86268609
94	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.85606497
95	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	0.85434170
96	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.85430724
97	CRX_20693478_ChIP-Seq_RETINA_Mouse	0.84200661
98	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.83652360
99	NANOG_20526341_ChIP-Seq_ESCs_Human	0.83275831
100	TAF15_26573619_Chip-Seq_HEK293_Human	0.82795104

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.45192475
2	MP0003693_abnormal_embryo_hatching	4.82023838
3	MP0008004_abnormal_stomach_pH	3.94077054
4	MP0005646_abnormal_pituitary_gland	3.61954426
5	MP0002638_abnormal_pupillary_reflex	3.14344596
6	MP0008789_abnormal_olfactory_epithelium	3.07619159
7	MP0005499_abnormal_olfactory_system	2.62041960
8	MP0005394_taste/olfaction_phenotype	2.62041960
9	MP0001929_abnormal_gametogenesis	2.50530625
10	MP0003698_abnormal_male_reproductive	2.42216650
11	MP0008058_abnormal_DNA_repair	2.41567779
12	MP0002210_abnormal_sex_determination	2.39424359
13	MP0002139_abnormal_hepatobiliary_system	2.37995813
14	MP0000566_synostosis	2.25434421
15	MP0005410_abnormal_fertilization	2.18531569
16	MP0005076_abnormal_cell_differentiation	2.17516622
17	MP0002160_abnormal_reproductive_system	2.13993388
18	MP0001984_abnormal_olfaction	2.12536326
19	MP0001764_abnormal_homeostasis	2.02689212
20	MP0009697_abnormal_copulation	1.95180950
21	MP0001145_abnormal_male_reproductive	1.92720312
22	MP0005171_absent_coat_pigmentation	1.86652313
23	MP0010094_abnormal_chromosome_stability	1.86574102
24	MP0000653_abnormal_sex_gland	1.84206589
25	MP0006072_abnormal_retinal_apoptosis	1.79432592
26	MP0003567_abnormal_fetal_cardiomyocyte	1.72472285
27	MP0009115_abnormal_fat_cell	1.71274918
28	MP0010368_abnormal_lymphatic_system	1.70958541
29	MP0002138_abnormal_hepatobiliary_system	1.68201713
30	MP0005253_abnormal_eye_physiology	1.67225282
31	MP0003718_maternal_effect	1.54018851
32	MP0001502_abnormal_circadian_rhythm	1.51205625
33	MP0005451_abnormal_body_composition	1.50387678
34	MP0003763_abnormal_thymus_physiology	1.41321461
35	MP0005389_reproductive_system_phenotype	1.41295573
36	MP0005551_abnormal_eye_electrophysiolog	1.33642425
37	MP0006035_abnormal_mitochondrial_morpho	1.25174476
38	MP0010386_abnormal_urinary_bladder	1.20081936
39	MP0002161_abnormal_fertility/fecundity	1.17038168
40	MP0003315_abnormal_perineum_morphology	1.13400171
41	MP0003656_abnormal_erythrocyte_physiolo	1.12952534
42	MP0002837_dystrophic_cardiac_calcinosis	1.10854046
43	MP0001851_eye_inflammation	1.09462056
44	MP0009785_altered_susceptibility_to	1.08610585
45	MP0006036_abnormal_mitochondrial_physio	1.08436137
46	MP0002653_abnormal_ependyma_morphology	1.04566712
47	MP0004215_abnormal_myocardial_fiber	1.04425101
48	MP0003186_abnormal_redox_activity	1.02434323
49	MP0002166_altered_tumor_susceptibility	1.01589189
50	MP0001730_embryonic_growth_arrest	1.00770069
51	MP0002006_tumorigenesis	0.95766642
52	MP0008932_abnormal_embryonic_tissue	0.95728901
53	MP0003077_abnormal_cell_cycle	0.92770514
54	MP0000372_irregular_coat_pigmentation	0.91344614
55	MP0001119_abnormal_female_reproductive	0.89690154
56	MP0001270_distended_abdomen	0.89545125
57	MP0000427_abnormal_hair_cycle	0.88382438
58	MP0004885_abnormal_endolymph	0.86857001
59	MP0003111_abnormal_nucleus_morphology	0.86783034
60	MP0004782_abnormal_surfactant_physiolog	0.83344357
61	MP0001324_abnormal_eye_pigmentation	0.82485887
62	MP0001944_abnormal_pancreas_morphology	0.81522201
63	MP0000026_abnormal_inner_ear	0.79567125
64	MP0000858_altered_metastatic_potential	0.79151229
65	MP0003699_abnormal_female_reproductive	0.78999415
66	MP0001919_abnormal_reproductive_system	0.78752583
67	MP0002078_abnormal_glucose_homeostasis	0.78740434
68	MP0008995_early_reproductive_senescence	0.78623385
69	MP0005647_abnormal_sex_gland	0.77777564
70	MP0004264_abnormal_extraembryonic_tissu	0.77752866
71	MP0001664_abnormal_digestion	0.76983016
72	MP0000383_abnormal_hair_follicle	0.76359213
73	MP0001661_extended_life_span	0.75993538
74	MP0003786_premature_aging	0.74364222
75	MP0003121_genomic_imprinting	0.74187570
76	MP0002909_abnormal_adrenal_gland	0.72519030
77	MP0001191_abnormal_skin_condition	0.72448523
78	MP0002970_abnormal_white_adipose	0.71106268
79	MP0001963_abnormal_hearing_physiology	0.69727226
80	MP0000631_abnormal_neuroendocrine_gland	0.69368860
81	MP0002928_abnormal_bile_duct	0.68873897
82	MP0005332_abnormal_amino_acid	0.68854646
83	MP0000358_abnormal_cell_content/	0.68533906
84	MP0000490_abnormal_crypts_of	0.66112217
85	MP0010307_abnormal_tumor_latency	0.66020890
86	MP0005395_other_phenotype	0.64947225
87	MP0002009_preneoplasia	0.64014303
88	MP0002233_abnormal_nose_morphology	0.63438939
89	MP0005452_abnormal_adipose_tissue	0.62962379
90	MP0004134_abnormal_chest_morphology	0.62413532
91	MP0004197_abnormal_fetal_growth/weight/	0.61812470
92	MP0002938_white_spotting	0.61698218
93	MP0005448_abnormal_energy_balance	0.61305866
94	MP0005384_cellular_phenotype	0.60632742
95	MP0001666_abnormal_nutrient_absorption	0.60527310
96	MP0004147_increased_porphyrin_level	0.57668300
97	MP0004484_altered_response_of	0.55664025
98	MP0009765_abnormal_xenobiotic_induced	0.54147854
99	MP0002723_abnormal_immune_serum	0.53851781
100	MP0002693_abnormal_pancreas_physiology	0.53376617

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Progressive inability to walk (HP:0002505)	4.03017980
2	Chromsome breakage (HP:0040012)	3.86257397
3	Hypoplasia of the uterus (HP:0000013)	3.82104458
4	Aplasia/hypoplasia of the uterus (HP:0008684)	3.73231458
5	Degeneration of the lateral corticospinal tracts (HP:0002314)	3.51186668
6	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	3.51186668
7	Meckel diverticulum (HP:0002245)	3.49359903
8	Abnormality of the ileum (HP:0001549)	3.36815189
9	Aplasia/Hypoplasia of the uvula (HP:0010293)	3.29831152
10	Chromosomal breakage induced by crosslinking agents (HP:0003221)	3.25383149
11	Reduced antithrombin III activity (HP:0001976)	3.23472914
12	Congenital primary aphakia (HP:0007707)	3.12680048
13	Medial flaring of the eyebrow (HP:0010747)	3.11485011
14	Oligodactyly (hands) (HP:0001180)	3.11033286
15	Abnormality of chromosome stability (HP:0003220)	3.02899322
16	Abnormality of lateral ventricle (HP:0030047)	3.00488397
17	Abnormality of the preputium (HP:0100587)	2.98707852
18	Gait imbalance (HP:0002141)	2.96315259
19	Pancreatic cysts (HP:0001737)	2.93022921
20	Small intestinal stenosis (HP:0012848)	2.90448101
21	Duodenal stenosis (HP:0100867)	2.90448101
22	Clubbing of toes (HP:0100760)	2.85875465
23	Poor coordination (HP:0002370)	2.83388655
24	Chronic hepatic failure (HP:0100626)	2.81843599
25	Pancreatic fibrosis (HP:0100732)	2.76927120
26	Nephrogenic diabetes insipidus (HP:0009806)	2.76561261
27	Pigmentary retinal degeneration (HP:0001146)	2.75188882
28	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.69381326
29	Absent/shortened dynein arms (HP:0200106)	2.69381326
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.64871392
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.64871392
32	Abnormal protein glycosylation (HP:0012346)	2.64871392
33	Abnormal glycosylation (HP:0012345)	2.64871392
34	Enlarged epiphyses (HP:0010580)	2.60690930
35	Volvulus (HP:0002580)	2.55000322
36	True hermaphroditism (HP:0010459)	2.53124385
37	Abnormal ciliary motility (HP:0012262)	2.51846896
38	Oligodactyly (HP:0012165)	2.50541189
39	Abnormality of the duodenum (HP:0002246)	2.50417298
40	Type II lissencephaly (HP:0007260)	2.47559850
41	Inability to walk (HP:0002540)	2.47188357
42	Abnormality of the corticospinal tract (HP:0002492)	2.43204556
43	Rhabdomyosarcoma (HP:0002859)	2.39267811
44	Type I transferrin isoform profile (HP:0003642)	2.38581345
45	Nephronophthisis (HP:0000090)	2.38324886
46	Metaphyseal dysplasia (HP:0100255)	2.37814222
47	Median cleft lip (HP:0000161)	2.37286793
48	Brushfield spots (HP:0001088)	2.34464961
49	Birth length less than 3rd percentile (HP:0003561)	2.32429364
50	Intestinal atresia (HP:0011100)	2.31824834
51	Abnormal respiratory motile cilium morphology (HP:0005938)	2.28098402
52	Abnormal respiratory epithelium morphology (HP:0012253)	2.28098402
53	Abnormal respiratory motile cilium physiology (HP:0012261)	2.24855811
54	Abnormality of the carotid arteries (HP:0005344)	2.21661362
55	Tubulointerstitial nephritis (HP:0001970)	2.20441349
56	Male pseudohermaphroditism (HP:0000037)	2.19310654
57	Premature ovarian failure (HP:0008209)	2.18568717
58	Dyschromatopsia (HP:0007641)	2.16707888
59	Cerebral hypomyelination (HP:0006808)	2.14854850
60	Abnormality of the renal medulla (HP:0100957)	2.14160361
61	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.13211479
62	Horseshoe kidney (HP:0000085)	2.11567371
63	Abnormality of midbrain morphology (HP:0002418)	2.08689872
64	Molar tooth sign on MRI (HP:0002419)	2.08689872
65	Facial hemangioma (HP:0000329)	2.08113257
66	Chin dimple (HP:0010751)	2.07812279
67	Congenital sensorineural hearing impairment (HP:0008527)	2.07382409
68	Genital tract atresia (HP:0001827)	2.06479740
69	Abnormality of macular pigmentation (HP:0008002)	2.05505354
70	Exotropia (HP:0000577)	2.05186021
71	Azoospermia (HP:0000027)	2.04947089
72	Astigmatism (HP:0000483)	2.02293849
73	Ectopic kidney (HP:0000086)	2.02116922
74	Hypoproteinemia (HP:0003075)	2.00874279
75	Ventricular fibrillation (HP:0001663)	1.99442937
76	Absent thumb (HP:0009777)	1.95980744
77	Triphalangeal thumb (HP:0001199)	1.95751013
78	Abnormal spermatogenesis (HP:0008669)	1.94866691
79	Abnormality of the line of Schwalbe (HP:0008048)	1.93581433
80	Aplasia/Hypoplasia of the lens (HP:0008063)	1.93275309
81	Anterior segment dysgenesis (HP:0007700)	1.91913944
82	Cystic liver disease (HP:0006706)	1.91768604
83	Hyperinsulinemic hypoglycemia (HP:0000825)	1.91606406
84	Short tibia (HP:0005736)	1.89626764
85	Ketosis (HP:0001946)	1.89055097
86	Multicystic kidney dysplasia (HP:0000003)	1.87756964
87	Posterior embryotoxon (HP:0000627)	1.86286854
88	Cerebellar dysplasia (HP:0007033)	1.85338498
89	Bile duct proliferation (HP:0001408)	1.85169033
90	Abnormal biliary tract physiology (HP:0012439)	1.85169033
91	Sloping forehead (HP:0000340)	1.85085507
92	Abnormality of the renal cortex (HP:0011035)	1.84116335
93	Vaginal atresia (HP:0000148)	1.83394514
94	Abnormality of DNA repair (HP:0003254)	1.81365332
95	Urinary urgency (HP:0000012)	1.80715785
96	Congenital hepatic fibrosis (HP:0002612)	1.80697436
97	Gastrointestinal atresia (HP:0002589)	1.79929163
98	Optic neuritis (HP:0100653)	1.78429769
99	Retrobulbar optic neuritis (HP:0100654)	1.78429769
100	Retinal dysplasia (HP:0007973)	1.72712785

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK1	6.27656848
2	RIPK1	5.07258148
3	PINK1	4.03007538
4	STK16	3.36640722
5	ZAK	3.31938756
6	TLK1	2.76009885
7	PRKD3	2.51717394
8	EIF2AK3	2.50685280
9	PIK3CA	2.46644801
10	TAOK3	2.40312469
11	TRIM28	2.39013263
12	PLK3	2.22722804
13	MAP2K6	2.18431422
14	FES	2.02164368
15	PKN2	1.91293899
16	MAP3K5	1.81911996
17	CDK8	1.81724248
18	ACVR1B	1.73948818
19	TNIK	1.70528923
20	MARK3	1.66621750
21	TYRO3	1.66141278
22	MST4	1.62634949
23	IRAK3	1.61834451
24	CDK3	1.59718656
25	IRAK2	1.54462382
26	IRAK1	1.52521591
27	BMPR1B	1.47859934
28	PRPF4B	1.34276890
29	TGFBR2	1.32581977
30	SRPK1	1.30823209
31	TRPM7	1.27725580
32	MAP4K2	1.26754756
33	MAP3K6	1.23796571
34	FRK	1.23314456
35	IKBKE	1.22013028
36	RET	1.19785621
37	RPS6KA5	1.11216300
38	PLK4	1.09688831
39	NUAK1	0.95682893
40	MELK	0.91666153
41	NEK2	0.89303418
42	NEK1	0.84250892
43	BRD4	0.84009923
44	PRKCE	0.80632363
45	ATM	0.79202915
46	PDGFRB	0.77822515
47	IRAK4	0.76758842
48	TBK1	0.75263584
49	BCR	0.73951727
50	PRKCQ	0.73776865
51	NEK6	0.68642762
52	TTK	0.68178739
53	MAP2K3	0.65488970
54	ADRBK2	0.65395115
55	PIM1	0.64604937
56	ATR	0.61274224
57	WEE1	0.58825609
58	PHKG1	0.58367426
59	PHKG2	0.58367426
60	MAP3K13	0.50015442
61	PLK1	0.48997599
62	FLT3	0.48963981
63	CHEK2	0.44568108
64	RPS6KB1	0.43684573
65	SIK3	0.40678750
66	MINK1	0.39657142
67	TIE1	0.37658011
68	CSNK1G2	0.37638474
69	PDK1	0.36337167
70	PDK2	0.34453901
71	PRKG1	0.32306790
72	JAK1	0.31725865
73	RPS6KA4	0.31390917
74	NLK	0.30001026
75	OXSR1	0.28916326
76	AURKB	0.28760593
77	CHUK	0.27416205
78	EGFR	0.27064878
79	PDPK1	0.26849150
80	MAPK13	0.26589461
81	PTK2B	0.26490698
82	CSNK1G3	0.23730276
83	CDC7	0.23709820
84	KIT	0.23442098
85	PRKAA1	0.23126439
86	MAPK7	0.21861428
87	BTK	0.19845914
88	PRKCI	0.19839129
89	MET	0.18448883
90	STK38L	0.18008907
91	ADRBK1	0.17506782
92	IGF1R	0.17256055
93	DYRK1A	0.16538923
94	CSNK1D	0.16210463
95	VRK2	0.15596739
96	PLK2	0.14231664
97	MAP2K4	0.13973105
98	ABL1	0.13753463
99	TGFBR1	0.12675166
100	WNK4	0.12660596

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	4.42438775
2	Mismatch repair_Homo sapiens_hsa03430	4.36195319
3	Selenocompound metabolism_Homo sapiens_hsa00450	4.21787598
4	Nucleotide excision repair_Homo sapiens_hsa03420	3.29740239
5	Fanconi anemia pathway_Homo sapiens_hsa03460	3.21534908
6	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	3.05927689
7	Basal transcription factors_Homo sapiens_hsa03022	2.90830935
8	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	2.75291074
9	DNA replication_Homo sapiens_hsa03030	2.30670081
10	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	2.24168651
11	One carbon pool by folate_Homo sapiens_hsa00670	2.15756574
12	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	2.09429296
13	Propanoate metabolism_Homo sapiens_hsa00640	1.99640491
14	Butanoate metabolism_Homo sapiens_hsa00650	1.91979148
15	RNA transport_Homo sapiens_hsa03013	1.81645330
16	Proteasome_Homo sapiens_hsa03050	1.81318157
17	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	1.80155856
18	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.75797395
19	RNA degradation_Homo sapiens_hsa03018	1.66581921
20	mRNA surveillance pathway_Homo sapiens_hsa03015	1.62789546
21	Nitrogen metabolism_Homo sapiens_hsa00910	1.47569787
22	Alcoholism_Homo sapiens_hsa05034	1.47481966
23	Peroxisome_Homo sapiens_hsa04146	1.46982055
24	Oocyte meiosis_Homo sapiens_hsa04114	1.27479743
25	Systemic lupus erythematosus_Homo sapiens_hsa05322	1.25352657
26	Base excision repair_Homo sapiens_hsa03410	1.22631333
27	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.16382876
28	Hepatitis B_Homo sapiens_hsa05161	1.12831571
29	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.12335296
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.11693069
31	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.10494916
32	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.10336714
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.05810124
34	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.01899491
35	Phototransduction_Homo sapiens_hsa04744	1.00670662
36	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.99078342
37	Cell cycle_Homo sapiens_hsa04110	0.97200664
38	Viral carcinogenesis_Homo sapiens_hsa05203	0.95604538
39	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.91735387
40	Glucagon signaling pathway_Homo sapiens_hsa04922	0.91436233
41	Tryptophan metabolism_Homo sapiens_hsa00380	0.90415808
42	Olfactory transduction_Homo sapiens_hsa04740	0.89439322
43	Insulin secretion_Homo sapiens_hsa04911	0.85738063
44	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.83537006
45	Spliceosome_Homo sapiens_hsa03040	0.81016918
46	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.80772592
47	Non-homologous end-joining_Homo sapiens_hsa03450	0.78334724
48	Protein export_Homo sapiens_hsa03060	0.77876723
49	Apoptosis_Homo sapiens_hsa04210	0.77735618
50	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.77573757
51	Glutathione metabolism_Homo sapiens_hsa00480	0.73681883
52	Linoleic acid metabolism_Homo sapiens_hsa00591	0.69661683
53	Primary immunodeficiency_Homo sapiens_hsa05340	0.68921945
54	Cocaine addiction_Homo sapiens_hsa05030	0.68675478
55	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64891487
56	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.64392511
57	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.63383225
58	Fatty acid metabolism_Homo sapiens_hsa01212	0.62874636
59	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.62686233
60	TNF signaling pathway_Homo sapiens_hsa04668	0.60868571
61	Legionellosis_Homo sapiens_hsa05134	0.60492396
62	Measles_Homo sapiens_hsa05162	0.60337460
63	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60086036
64	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.57767078
65	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.56078833
66	p53 signaling pathway_Homo sapiens_hsa04115	0.55129195
67	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.54294087
68	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.53890990
69	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.52620157
70	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.52373187
71	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49754042
72	Purine metabolism_Homo sapiens_hsa00230	0.49434163
73	Circadian rhythm_Homo sapiens_hsa04710	0.48907418
74	Dopaminergic synapse_Homo sapiens_hsa04728	0.48790981
75	Regulation of autophagy_Homo sapiens_hsa04140	0.46157560
76	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.45103578
77	Gap junction_Homo sapiens_hsa04540	0.43895540
78	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.42440522
79	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.40439596
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.40347156
81	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.40295452
82	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.40135672
83	Amphetamine addiction_Homo sapiens_hsa05031	0.39187540
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.33939640
85	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.30964320
86	Pyrimidine metabolism_Homo sapiens_hsa00240	0.30587609
87	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.29751305
88	Influenza A_Homo sapiens_hsa05164	0.28550211
89	Metabolic pathways_Homo sapiens_hsa01100	0.28062908
90	Lysine degradation_Homo sapiens_hsa00310	0.26683260
91	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.26584026
92	Caffeine metabolism_Homo sapiens_hsa00232	0.26362490
93	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.25850611
94	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.24421095
95	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.24006333
96	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.22628697
97	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.21150543
98	RNA polymerase_Homo sapiens_hsa03020	0.20579166
99	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.20092901
100	Fatty acid elongation_Homo sapiens_hsa00062	0.20027892

RPL7P42

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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